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1

Dalle Ave, Anne L., and David M. Shaw. "Controlled Donation After Circulatory Determination of Death." Journal of Intensive Care Medicine 32, no. 3 (2016): 179–86. http://dx.doi.org/10.1177/0885066615625628.

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Controlled donation after circulatory determination of death (cDCDD) concerns donation after withdrawal of life-sustaining therapy (W-LST). We examine the ethical issues raised by W-LST in the cDCDD context in the light of a review of cDCDD protocols and the ethical literature. Our analysis confirms that W-LST procedures vary considerably among cDCDD centers and that despite existing recommendations, the conflict of interest in the W-LST decision and process might be difficult to avoid, the process of W-LST might interfere with usual end-of-life care, and there is a risk of hastening death. In
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2

Clark, Stephen. "Ethical considerations in controlled donation after circulatory death." Annals of Cardiothoracic Surgery 14, no. 1 (2025): 61–63. https://doi.org/10.21037/acs-2024-dcd-25.

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3

Rodrigue, James R., Richard Luskin, Helen Nelson, Alexandra Glazier, Galen V. Henderson, and Francis L. Delmonico. "Measuring Critical Care Providers’ Attitudes About Controlled Donation After Circulatory Death." Progress in Transplantation 28, no. 2 (2018): 142–50. http://dx.doi.org/10.1177/1526924818765821.

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Introduction: Unfavorable attitudes and insufficient knowledge about donation after cardiac death among critical care providers can have important consequences for the appropriate identification of potential donors, consistent implementation of donation after cardiac death policies, and relative strength of support for this type of donation. The lack of reliable and valid assessment measures has hampered research to capture providers’ attitudes. Design and Research Aims: Using stakeholder engagement and an iterative process, we developed a questionnaire to measure attitudes of donation after c
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4

Inci, Ilhan, Sven Hillinger, Didier Schneiter, et al. "Lung Transplantation with Controlled Donation after Circulatory Death Donors." Annals of Thoracic and Cardiovascular Surgery 24, no. 6 (2018): 296–302. http://dx.doi.org/10.5761/atcs.oa.18-00098.

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5

Callaghan, C. J., M. S. Qureshi, J. A. Bradley, C. J. E. Watson, and G. J. Pettigrew. "Pancreas Transplantation From Controlled Donation After Circulatory Death Donors." American Journal of Transplantation 13, no. 3 (2013): 823. http://dx.doi.org/10.1111/ajt.12030.

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6

Hessheimer, A. J., B. Domínguez-Gil, C. Fondevila, and R. Matesanz. "Controlled Donation After Circulatory Determination of Death in Spain." American Journal of Transplantation 16, no. 7 (2016): 2239–40. http://dx.doi.org/10.1111/ajt.13762.

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7

Pérez-Villares, Jose Miguel, Ramón Lara-Rosales, Alberto Fernández-Carmona, Patricia Fuentes-Garcia, Manuel Burgos-Fuentes, and Blas Baquedano-Fernández. "Mobile ECMO team for controlled donation after circulatory death." American Journal of Transplantation 18, no. 5 (2018): 1293–94. http://dx.doi.org/10.1111/ajt.14656.

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8

Brogi, Etrusca, Alessandro Circelli, Emiliano Gamberini, et al. "Normothermic Regional Perfusion for Controlled Donation After Circulatory Death." ASAIO Journal 66, no. 1 (2020): e19-e21. http://dx.doi.org/10.1097/mat.0000000000000963.

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9

Gutiérrez Delgado, María del Pilar, Belinda Sánchez Pérez, Jose Antonio Pérez Daga, Francisco Javier León Díaz, and Julio Santoyo Santoyo. "Controlled donation after circulatory death: A present in pancreatic trasnplant." Cirugía Española (English Edition) 99, no. 3 (2021): 236–38. http://dx.doi.org/10.1016/j.cireng.2021.02.015.

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10

Gutiérrez Delgado, M. D. P., B. Sánchez Pérez, J. A. Pérez Daga, F. J. León Díaz, and J. Santoyo Santoyo. "Controlled donation after circulatory death in pancreatic trasplant: our present." HPB 23 (2021): S770. http://dx.doi.org/10.1016/j.hpb.2021.08.200.

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11

Le Dorze, Matthieu, Laurent Martin-Lefèvre, Gaëlle Santin, et al. "Critical pathways for controlled donation after circulatory death in France." Anaesthesia Critical Care & Pain Medicine 41, no. 2 (2022): 101029. http://dx.doi.org/10.1016/j.accpm.2022.101029.

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12

Murphy, Nicholas, Charles Weijer, Maxwell Smith, et al. "Controlled Donation After Circulatory Determination of Death: A Scoping Review of Ethical Issues, Key Concepts, and Arguments." Journal of Law, Medicine & Ethics 49, no. 3 (2021): 418–40. http://dx.doi.org/10.1017/jme.2021.63.

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13

Savier, Eric, Chetana Lim, and Olivier Scatton. "Liver Transplantation From Controlled Donation After Circulatory Death Donors With Normothermic Regional Perfusion Versus Donation After Brain Death Donors." Liver Transplantation 28, no. 3 (2021): 508–9. http://dx.doi.org/10.1002/lt.26363.

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14

Kin, Tatsuya, Hirofumi Noguchi, and Atsushi Kawaguchi. "Is Donation after Circulatory Determination of Death in Japan Uncontrolled or Controlled?" OBM Transplantation 08, no. 02 (2024): 1–12. http://dx.doi.org/10.21926/obm.transplant.2402216.

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Using donation after circulatory determination of death (DCD) donors has been shown to be a potential means of increasing the number of donors for organ transplantation. The purpose of this study was to examine the published practice of DCD in Japan to properly define their practice as controlled or uncontrolled. Through the Web of Science database, we systematically searched articles describing uncontrolled DCD, controlled DCD or Maastricht classification. A total of 12 articles (ten articles related to kidney, one to pancreas, another to islet transplantation), which were published between 1
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15

Walker, Wendy, and Magi Sque. "Family bereavement: A case study of controlled organ donation after circulatory death." Nursing in Critical Care 24, no. 4 (2019): 229–34. http://dx.doi.org/10.1111/nicc.12436.

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16

Palomo-López, N., L. Martín-Villén, Á. J. Roldán-Reina, et al. "Results of Controlled Donation After Circulatory Death in a Third-Level Hospital." Transplantation Proceedings 50, no. 2 (2018): 536–38. http://dx.doi.org/10.1016/j.transproceed.2017.11.051.

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17

Cypel, Marcelo, Bronwyn Levvey, Dirk Van Raemdonck, et al. "Lung transplantation using controlled donation after circulatory death donors: Trials and tribulations." Journal of Heart and Lung Transplantation 35, no. 1 (2016): 146–47. http://dx.doi.org/10.1016/j.healun.2015.10.004.

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18

Okahara, Shuji, Gregory I. Snell, Mark McDonald, et al. "Improving the predictability of time to death in controlled donation after circulatory death lung donors." Transplant International 34, no. 5 (2021): 906–15. http://dx.doi.org/10.1111/tri.13862.

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19

Foss, Stein, Espen Nordheim, Dag W. Sørensen, et al. "First Scandinavian Protocol for Controlled Donation After Circulatory Death Using Normothermic Regional Perfusion." Transplantation Direct 4, no. 7 (2018): e366. http://dx.doi.org/10.1097/txd.0000000000000802.

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20

Weiss, Matthew J., Laura Hornby, Bram Rochwerg, et al. "Canadian Guidelines for Controlled Pediatric Donation After Circulatory Determination of Death—Summary Report*." Pediatric Critical Care Medicine 18, no. 11 (2017): 1035–46. http://dx.doi.org/10.1097/pcc.0000000000001320.

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21

Boffini, Massimo, Gino Gerosa, Giovanni Battista Luciani, et al. "Heart transplantation in controlled donation after circulatory determination of death: the Italian experience." Annals of Cardiothoracic Surgery 14, no. 1 (2025): 47–54. https://doi.org/10.21037/acs-2024-dcd-27.

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22

Inci, I., R. Lenherr, S. Hillinger, et al. "Lung Transplantation with Controlled Donation After Circulatory Death Donors: Initial Experience in Switzerland." Journal of Heart and Lung Transplantation 36, no. 4 (2017): S319. http://dx.doi.org/10.1016/j.healun.2017.01.1528.

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23

Guo, Mingxiao, Linlin Li, and Chunlei Lu. "Characterization of the withdrawal phase in a swine controlled intestinal donation after circulatory death model." Clinical & Investigative Medicine 37, no. 5 (2014): 331. http://dx.doi.org/10.25011/cim.v37i5.22013.

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Purpose: Transplantation of donation after cardiac death (DCD) intestine has higher rates of organ failure and complications. Fortunately, this is less grievous in a subclass of DCD called controlled (CDCD), those with irreversible but incomplete brain injury. The aim of the paper is to establish a CDCD porcine model which is closely mimicking human CDCD scenario, and investigate the physiologic changes from withdrawal of ventilatory support to circulatory arrest. Method: Ten domestic crossbred pigs were anesthetized and ventilated with room air. Once all baseline data was taken, atracurium be
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24

Pérez‐Sáez, María José, Javier Juega, Ana Zapatero, et al. "Kidney transplant outcomes in elderly recipients with controlled donation after circulatory death or donation after brain death donors: a registry cohort study." Transplant International 34, no. 12 (2021): 2507–14. http://dx.doi.org/10.1111/tri.14141.

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25

Domínguez-Gil, Beatriz, Nancy Ascher, Alexander M. Capron, et al. "Expanding controlled donation after the circulatory determination of death: statement from an international collaborative." Intensive Care Medicine 47, no. 3 (2021): 265–81. http://dx.doi.org/10.1007/s00134-020-06341-7.

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26

Feo, Marlene, Eduardo Miñambres, Borja Suberviola, et al. "Controlled Donation After Circulatory Death Program: Analysis and Results at a Tertiary Care Hospital." Transplantation Proceedings 54, no. 1 (2022): 70–72. http://dx.doi.org/10.1016/j.transproceed.2021.09.061.

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27

L, Vecchio Dezillio, Stringa P, Machuca M, et al. "O-06: Experimental Assessment of Multivisceral Graft Damage in Controlled Donation after Circulatory Death." Transplantation 105, no. 7S (2021): S3. http://dx.doi.org/10.1097/01.tp.0000757492.51854.0c.

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28

Oniscu, G. C., L. V. Randle, P. Muiesan, et al. "In SituNormothermic Regional Perfusion for Controlled Donation After Circulatory Death-The United Kingdom Experience." American Journal of Transplantation 14, no. 12 (2014): 2846–54. http://dx.doi.org/10.1111/ajt.12927.

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29

Gay, Samuel, Albrice Levrat, and Didier Dorez. "Controlled donation after circulatory death in France: first results of a nonuniversity pilot centre." Transplant International 31, no. 10 (2018): 1178–80. http://dx.doi.org/10.1111/tri.13309.

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30

Loforte, Antonio, Matteo Marro, Erika Simonato, et al. "Surgical techniques for cardiac allograft procurement and perfusion in controlled donation after circulatory death." Annals of Cardiothoracic Surgery 13, no. 6 (2024): 522–30. http://dx.doi.org/10.21037/acs-2024-dcd-26.

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31

Minambres, Eduardo, Nuria Lavid, Maite Arlaban, et al. "Excellent Results from Controlled Donation after Circulatory Death Donors Using Abdominal Normothermic Regional Perfusion." Transplantation 101 (August 2017): S37. http://dx.doi.org/10.1097/01.tp.0000525030.91140.d5.

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32

Palleschi, A., V. Musso, R. Lorenzo, et al. "Lung Transplantation from Controlled and Uncontrolled Donation after Circulatory Death Donors. Single Centre Experience." Journal of Heart and Lung Transplantation 39, no. 4 (2020): S376. http://dx.doi.org/10.1016/j.healun.2020.01.476.

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33

Kompanje, Erwin J. O., and Jelle L. Epker. "Controlled Donation After Circulatory Determination of Death: Ethical Issues in Withdrawing Life-Sustaining Therapy." Journal of Intensive Care Medicine 33, no. 4 (2018): 270–71. http://dx.doi.org/10.1177/0885066617733651.

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34

Lazzeri, Chiara, and Adriano Peris. "UNCONTROLLED DONATION AFTER CIRCULATORY DEATH: A BY-PRODUCT OF THE CONTROLLED? A NARRATIVE REVIEW." European Journal of Transplantation 1, no. 2 (2023): 136–42. http://dx.doi.org/10.57603/ejt-016.

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35

Morrissey, Paul. "Pragmatic Aspects of Controlled Donation after Circulatory Death and Ethical Considerations for Alternative Approaches." American Journal of Bioethics 23, no. 2 (2023): 14–17. http://dx.doi.org/10.1080/15265161.2022.2159251.

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36

Hoyos Mejia, L., T. Papasotiropoulos, G. Lang, et al. "Controlled Donation After Circulatory Death Lung Transplantation in University Hospital Zurich: 10-years' Experience." Journal of Heart and Lung Transplantation 43, no. 4 (2024): S111. http://dx.doi.org/10.1016/j.healun.2024.02.223.

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37

Tanaka, Shin, Jose Luis Campo-Cañaveral de la Cruz, Mariana Gil Barturen, et al. "Post-transplant outcomes of standard and extended criteria donation after circulatory death donor lungs categorized by donation after brain death lung criteria." European Journal of Cardio-Thoracic Surgery 60, no. 3 (2021): 590–97. http://dx.doi.org/10.1093/ejcts/ezab121.

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Abstract OBJECTIVES Most transplant centres use donation after brain death (DBD) criteria to assess the quality of controlled donation after circulatory death (cDCD) lungs. However, research on the relationship between DBD extended criteria and cDCD lung transplantation outcomes is limited. We investigated the outcomes of using DBD extended criteria donor organs in cDCD lung transplantation, compared to the standard criteria cDCD lung transplantation. METHODS A retrospective chart review of consecutive cDCD lung referrals to Hospital Universitario Puerta de Hierro-Majadahonda from June 2013 to
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38

Hodgson, R., A. Young, M. Attia, and P. Lodge. "Impact of a National Controlled Donation After Circulatory Death (DCD) Programme on Organ Donation: A 10 Year Study." HPB 21 (2019): S772. http://dx.doi.org/10.1016/j.hpb.2019.10.670.

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39

Hodgson, R., A. Young, M. Attia, and P. Lodge. "Impact of a national controlled donation after circulatory death (DCD) programme on organ donation: a 10 year study." HPB 21 (2019): S1001—S1002. http://dx.doi.org/10.1016/j.hpb.2019.10.1353.

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40

Palomo-López, Nora, Ana Rodríguez-Rodríguez, Luis Martín-Villén, et al. "Immunomodulation of Oxidative Stress during Organ Donation Process: Preliminary Results." Healthcare 10, no. 5 (2022): 762. http://dx.doi.org/10.3390/healthcare10050762.

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The objective was to quantify oxidative stress resulting from ischemia during the donation process, using malondialdehyde (MDA) measurement, and its modulation by the administration of melatonin. We designed a triple-blind clinical trial with donors randomized to melatonin or placebo. We collected donors by donation after brain death (DBD) and controlled donation after circulatory death (DCD), the latter maintained by normothermic regional perfusion (NRP). Melatonin or placebo was administered prior to donation or following limitation of therapeutic effort (LTE). Demographic variables and medi
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41

Muller, Xavier, Guillaume Rossignol, Kayvan Mohkam, Mickaël Lesurtel, and Jean‐Yves Mabrut. "Dynamic Liver Graft Preservation in Controlled Donation After Circulatory Death: What Is the Best Fit?" Liver Transplantation 28, no. 2 (2021): 330–31. http://dx.doi.org/10.1002/lt.26333.

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42

Sanchez, P. G., M. Rouse, D. L. Pratt, et al. "Lung Donation After Controlled Circulatory Determination of Death: A Review of Current Practices and Outcomes." Transplantation Proceedings 47, no. 6 (2015): 1958–65. http://dx.doi.org/10.1016/j.transproceed.2015.06.026.

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43

Roldán-Reina, Á. J., J. J. Egea-Guerrero, N. Palomo-López, et al. "Postoperative Care in Kidney Transplantation: A Comparison Between Controlled and Uncontrolled Donation After Circulatory Death." Transplantation Proceedings 50, no. 2 (2018): 533–35. http://dx.doi.org/10.1016/j.transproceed.2017.11.058.

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44

Okamoto, T., H. Niikawa, C. Tu, et al. "Single Center Experience of Controlled Donation After Circulatory Death in Lung Transplantation at Cleveland Clinic." Journal of Heart and Lung Transplantation 37, no. 4 (2018): S241. http://dx.doi.org/10.1016/j.healun.2018.01.599.

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45

Ledoux, Didier, Marie-Hélène Delbouille, Arnaud Deroover, et al. "Does comfort therapy during controlled donation after circulatory death shorten the life of potential donors?" Clinical Transplantation 28, no. 1 (2013): 47–51. http://dx.doi.org/10.1111/ctr.12276.

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46

Ramos, Ana María Bellón, Marta Pérez Calle, Elisa Bueso Inchausti García, et al. "Succes rate of liver retrieval in normothermic regional perfusion during controlled donation after circulatory death." Journal of Critical Care 81 (June 2024): 154672. http://dx.doi.org/10.1016/j.jcrc.2024.154672.

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47

Magán, María Del Mar Martín, Ramón Mula Martínez, Marta Mateos Llosa, et al. "Heart transplants from controlled donation after the circulatory determination of death (CDD): Our initial experience." Journal of Critical Care 81 (June 2024): 154588. http://dx.doi.org/10.1016/j.jcrc.2024.154588.

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48

Hessheimer, Amelia J., Elisabeth Coll, Ferrán Torres, et al. "Normothermic regional perfusion vs. super-rapid recovery in controlled donation after circulatory death liver transplantation." Journal of Hepatology 70, no. 4 (2019): 658–65. http://dx.doi.org/10.1016/j.jhep.2018.12.013.

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49

Muller, X., G. Rossignol, S. Damotte, et al. "Graft utilization after normothermic regional perfusion in controlled donation after circulatory death - 5-year experience from France." HPB 23 (2021): S770—S772. http://dx.doi.org/10.1016/j.hpb.2021.08.201.

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50

Kotsopoulos, Angela M. M., Piet Vos, Nichon E. Jansen, Ewald M. Bronkhorst, Johannes G. van der Hoeven, and Wilson F. Abdo. "Prediction Model for Timing of Death in Potential Donors After Circulatory Death (DCD III): Protocol for a Multicenter Prospective Observational Cohort Study." JMIR Research Protocols 9, no. 6 (2020): e16733. http://dx.doi.org/10.2196/16733.

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Background Controlled donation after circulatory death (cDCD) is a major source of organs for transplantation. A potential cDCD donor poses considerable challenges in terms of identification of those dying within the predefined time frame of warm ischemia after withdrawal of life-sustaining treatment (WLST) to circulatory arrest. Several attempts have been made to develop models predicting the time between treatment withdrawal and circulatory arrest. This time window determines whether organ donation can occur and influences the quality of the donated organs. However, the selected patients use
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