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Journal articles on the topic 'Controlled Drug Delivery System'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

SHARMA, PRASHANT. "Pulsatile Drug Delivery System – A Novel Approach for Time and Spatial Controlled Drug Delivery." Journal of Pharmaceutical Technology, Research and Management 4, no. 1 (2016): 13–29. http://dx.doi.org/10.15415/jptrm.2016.41002.

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Disha A Deulkar, Jitendra A Kubde, Pooja R Hatwar, and Ravindrakumar L Bakal. "A review on transdermal drug delivery system." GSC Advanced Research and Reviews 18, no. 2 (2024): 347–61. http://dx.doi.org/10.30574/gscarr.2024.18.2.0052.

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Drugs that are applied topically are delivered using transdermal drug delivery devices. These are pharmaceutical preparations of varying sizes, containing one or more active ingredients, intended to be applied to the unbroken skin in order to deliver the active ingredient after passing through the skin barriers, and these avoid first pass metabolism. Today about 74% of drugs are taken orally and are not found effective as desired. To improve efficacy transdermal drug delivery system was emerged. A notable advantage of transdermal drug delivery compared to other methods like oral, topical, intr

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Disha, A. Deulkar, A. Kubde Jitendra, R. Hatwar Pooja, and L. Bakal Ravindrakumar. "A review on transdermal drug delivery system." GSC Advanced Research and Reviews 18, no. 2 (2024): 347–61. https://doi.org/10.5281/zenodo.11216528.

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Drugs that are applied topically are delivered using transdermal drug delivery devices. These are pharmaceutical preparations of varying sizes, containing one or more active ingredients, intended to be applied to the unbroken skin in order to deliver the active ingredient after passing through the skin barriers, and these avoid first pass metabolism. Today about 74% of drugs are taken orally and are not found effective as desired. To improve efficacy transdermal drug delivery system was emerged. A notable advantage of transdermal drug delivery compared to other methods like oral, topical, intr

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Gupta, Brahma Prakash, Navneet Thakur, Nishi P. Jain, Jitendra Banweer, and Surendra Jain. "Osmotically Controlled Drug Delivery System with Associated Drugs." Journal of Pharmacy & Pharmaceutical Sciences 13, no. 4 (2010): 571. http://dx.doi.org/10.18433/j38w25.

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Conventional drug delivery systems have slight control over their drug release and almost no control over the effective concentration at the target site. This kind of dosing pattern may result in constantly changing, unpredictable plasma concentrations. Drugs can be delivered in a controlled pattern over a long period of time by the controlled or modified release drug delivery systems. They include dosage forms for oral and transdermal administration as well as injectable and implantable systems. For most of drugs, oral route remains as the most acceptable route of administration. Certain mole

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Pandey, Parijat, Manisha Saini, and Neeta . "Mucoadhesive drug delivery system: an overview." Pharmaceutical and Biological Evaluations 4, no. 4 (2017): 183. http://dx.doi.org/10.26510/2394-0859.pbe.2017.29.

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The major objective of any dosage form is to deliver an optimum therapeutic amount of active agent to the proper site in the body to attain constant & maintenance of the desired drug concentration. Mucoadhesive drug delivery systems are effective delivery systems with various advantages as compared to other oral controlled release dosage forms in terms of drug delivery at specific sites with prolonged retention time of drugs at target sites. The main advantage of these systems includes avoiding first pass metabolism of the drugs and hence availability of high drug concentration at target s

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Tanvir, Karajagikar*1 Anil Panchal2 Vishal Madankar3. "Microsphere as Novel Drug Delivery System." International Journal of Scientific Research and Technology 2, no. 2 (2025): 65–69. https://doi.org/10.5281/zenodo.14836892.

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Microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers which are biodegradable in nature and ideally having a particle size less than 200 µm. A welldesigned controlled drug delivery system can overcome some of the problems of conventional therapy and enhance the therapeutic efficacy of a given drug. There are various approaches in delivering a therapeutic substance to the target site in a sustained controlled release fashion. One such approach is using microspheres as carriers for drugs. It is the reliable means to deliver the drug to the ta

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Prasanna, N. *1 Srilatha Ch. 2. Subrahmanyam C. V. S.3. "Osmotic Controlled Release Oral Delivery System: An Overview." International Journal in Pharmaceutical Sciences 2, no. 3 (2024): 530–58. https://doi.org/10.5281/zenodo.10810393.

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Osmotic drug delivery systems (ODDS) are a type of controlled release technology that utilizes the principles of osmosis to deliver drugs in a precise and sustained manner. These systems typically consist of a core containing the drug and an osmotic agent, surrounded by a semipermeable membrane. Water from the surrounding environment draws in through the membrane due to the osmotic pressure generated by the core, pushing the drug solution out through a predefined delivery orifice in a controlled manner. Osmotic drug delivery devices, such as the Rose and Nelson pump, Higuchi Leeper pump, Higuc

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Divya, M. Ramchandani* Brijesh R. Humbal and Bhulesh V. Paida. "Role of Nanoparticles in Drug Delivery System." Science World a monthly e magazine 2, no. 11 (2022): 1877–83. https://doi.org/10.5281/zenodo.7358409.

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Nanomedicine and nano delivery systems are new but rapidly developing science which serve as means of diagnostic tools or to deliver therapeutic agents to specific targeted sites in a controlled manner. Novel drug delivery systems have several advantages over conventional multi dose therapy. Drug designing at the nanoscale has been of its potential advantages such as the possibility to modify properties like solubility, drug release profiles, diffusivity, bioavailability and immunogenicity. Nanoparticles can offer significant advantages in terms of high stability, high specificity, high drug c

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9

Rajput, Rajesh, K. M. K. Prasanna Kumar, D. S. Arya, et al. "Osmotic controlled drug delivery system (OSMO technology) and its impact on diabetes care." International Journal of Research in Medical Sciences 9, no. 1 (2020): 303. http://dx.doi.org/10.18203/2320-6012.ijrms20205861.

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Recently, focus on the development of controlled release drug delivery system has increased, as existing drugs exhibit certain pharmacokinetic limitations. The major goal of designing sustained release formulations is to improve the drug performance by prolonged duration of drug action, decreased frequency of dosing and reduced side effects by using smallest quantity of drug administered by the most suitable route. Osmotic-controlled release oral delivery system (OSMO technology) is the most promising strategy based system for sustained delivery of drug. Drug can be delivered in a controlled m

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10

S.K, Ghate Dr. D.M.Sakarkar. "DEVELOPMENT AND EVALUATION OF OSMOTICALLY CONTROLLED ORAL DRUG DELIVERY SYSTEM." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 09 (2017): 459–70. https://doi.org/10.5281/zenodo.1036415.

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Conventional drug delivery systems have slight control over their drug release and almost no control over the effective concentration at the target site. This kind of dosing pattern may result in constantly changing, unpredictable plasma concentrations. Drugs can be delivered in a controlled pattern over a long period of time by the controlled or modified release drug delivery systems. They include dosage forms for oral and transdermal administration as well as injectable and implantable systems. For most of drugs, oral route remains as the most acceptable route of administration. Certain mole

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11

Venkateswarlu, B. S., C. Pasupathi, A. Pasupthi, B. Jaykar, R. Margret Chandira, and P. Palanisamy. "Osmotic drug delivery system: A review." Journal of Drug Delivery and Therapeutics 9, no. 2-s (2019): 611–16. http://dx.doi.org/10.22270/jddt.v9i2-s.2506.

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Osmotic drug delivery uses the osmotic pressure level for controlled delivery of drugs by using osmogens. Osmotic systems for controlled drug-delivery applications are well established, both in human pharmaceuticals and in veterinary medicine. The process of osmosis is that can control the drug delivery system. Osmotic pressure created from external environment into the dosage form regulates the delivery of drug from osmotic device. Osmotic pumps are promising systems for controlled drug delivery. The systems are used for oral administration and implantation. Osmotic pumps consist of an inner

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RK, Gunda. "Transdermal Drug Delivery System: An Emphasis on Transdermal Patches." Pharmaceutical Drug Regulatory Affairs Journal 6, no. 1 (2023): 1–5. http://dx.doi.org/10.23880/pdraj-16000147.

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Transdermal drug delivery system was presented to overcome the difficulties of drug delivery especially oral route. A transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream. It promotes healing to an injured area of the body. An advantage of a transdermal drug delivery route over other types of delivery system such as oral, topical, i.v., i.m., etc. is that the patch provides a controlled release of the medication into the patient, usually through either a porous membrane covering a reservoir

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13

Zaman, Muhammad, Junaid Qureshi, Hira Ejaz, et al. "Oral controlled release drug delivery system and Characterization of oral tablets; A review." Pakistan Journal of Pharmaceutical Research 2, no. 1 (2016): 67. http://dx.doi.org/10.22200/pjpr.2016167-76.

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Oral route of drug administration is considered as the safest and easiest route of drug administration. Control release drug delivery system is the emerging trend in the pharmaceuticals and the oral route is most suitable for such kind of drug delivery system. Oral route is more convenient for It all age group including both pediatric and geriatrics. There are various systems which are adopted to deliver drug in a controlled manner to different target sites through oral route. It includes diffusion controlled drug delivery systems; dissolution controlled drug delivery systems, osmotically cont

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Shep, Santosh, Sham Dodiya, Sandeep Lahoti, and Rahul Mayee. "Swelling System: A Novel Approach Towards Gastroretentive Drug Delivery System." Indo Global Journal of Pharmaceutical Sciences 01, no. 03 (2011): 234–42. http://dx.doi.org/10.35652/igjps.2011.23.

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Swelling Drug delivery system are designed to prolong the gastric residence time after oral administration, at particular site and controlling the release of drug especially useful for achieving controlled plasma level as well as improving bioavailability. In recent years scientific and technological advancements have been made in the research and development of controlled release oral drug delivery systems by overcoming physiological adversities like short gastric residence times and unpredictable gastric emptying times. Swelling drug delivery systems is the system which is retained in the st

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SWETHA, T* MRS.TANUSH REE CHAKRABORTY. "NANOSPONGES: NEW COLLOIDAL DRUG DELIVERY SYSTEM FOR TOPICAL DRUG DELIVERY." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 02 (2019): 4263–76. https://doi.org/10.5281/zenodo.2574445.

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<em>The advent of nanotechnology lead to invention of many dosage forms. Effective targeted drug delivery systems have been a dream for a long time, due to several major drawbacks, a practical approach has been developed for the formation of discrete functionalized particles, which have been termed as ‘Nanosponge’. The development of new colloidal carrier called Nanosponges has the potential to solve these problems. Nanosponge is a novel and emerging technology it can precisely control the release rates of controlled drug delivery for topical use. The invention of Nanosponges has b

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Ankit Kumar and Sanjeev Kumar. "Intra Vaginal Drug Delivery System (Novel Drug Delivery System)." International Journal for Research in Applied Sciences and Biotechnology 7, no. 6 (2020): 234–41. http://dx.doi.org/10.31033/ijrasb.7.6.33.

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In case of intra-vaginal route of drug administration the dosage form is applied vaginally for the convenient release of the dosage form and for better therapeutic action of the medicament, it is usually used in HIV patients. many conditions that affect the female reproductive tract, such as , sexually transmitted diseases, fungal & bacterial infections, cancer and various pathogens such as virus (human immunodeficiency virus, HIV), bacteria (Gardnerella vaginalis), fungi (Candida spp.) or parasites (Trichomonas vaginalis). Systemically active drugs (contraceptive steroids) as well as loca

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Agrawal, Nimesh, Navneet Kumar Verma, Saumya Srivastava, and Sanch Srivastava. "Colon Specific and Targeted Drug Delivery System (CDDS): A Review." Scholars Academic Journal of Pharmacy 13, no. 06 (2024): 208–14. http://dx.doi.org/10.36347/sajp.2024.v13i06.001.

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In the recent year colonic drug delivery is important for delivery of drug for the treatment of local disease. Targeted drug delivery into the colon is highly desirable for local treatment of a variety of bowel diseases such as ulcerative colitis, Crohn’s disease, amoebiosis, colonic cancer, local treatment of colonic pathologies, and systemic delivery of protein and peptide drugs. This article gives overview on different approaches of colon targeted drug delivery system such as pH sensitive polymer coated drug delivery to colon, time Controlled release drug delivery to Colon microbially trigg

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18

Aesha, Matroja, Sneha Singh Miss., and Karunakar Shukla Dr. "Formulation and evaluation of microsphere of Dalbergia sisso and its antimicrobial activity." Pharmaceutical and Chemical Journal 10, no. 5 (2023): 18–44. https://doi.org/10.5281/zenodo.13997571.

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Microspheres play a very important role as particulate drug delivery system because of their small size and other efficient properties. These have been proved to be a suitable bridge to scale the distance over to formulate an effective dosage form, so simulate controlled drag release. These microspheres are used for drug delivery, wherein the drug can be encapsulated or in entrapped form Polymeric microspheres are ideal vehicles for many controlled delivery applications due to their ability to encapsulate a variety of drugs, biocompatibility, high bioavailability and sustained drug release cha

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Sharma, Amit, Damit Kumar, and Neelam Painuly. "A REVIEW ON OSMOTICALLY CONTROLLED DRUG DELIVERY SYSTEMS." Asian Journal of Pharmaceutical Research and Development 6, no. 4 (2018): 101–9. http://dx.doi.org/10.22270/ajprd.v6i4.383.

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Osmotically controlling drug delivery system is one of the best method of drug technology it is highly fruitful and effective. In this osmotic pressure is used to deliver drug properly as osmosis is the movement from lower concentration to the higher concentration. By this system we can release drug in proper manner as it is widely accepted technique with interesting facts and use. There are various drug delivery components like drugs. Osmotic agent and semi permeable membrane all are essential and have their own role to play, It is one of the best in best method used now a days to get best re

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Anurag, Mishra* Mohd. Aqil Siddiqui. "A Overview of the Transdermal Drug Delivery System." International Journal in Pharmaceutical Sciences 1, no. 9 (2023): 391–96. https://doi.org/10.5281/zenodo.8363004.

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The skin offers an accessible & convenient site for the administration of medication. The transdermal drug delivery system has been a safe &effective drug delivery system, it aims to deliver the drug through the skin at a predetermined rate and controlled rate. If a drug has the right mix of physical chemistry and pharmacology, transdermal delivery is a remarkably effective route of administration. The transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose & medication through the skin & into the bloodstream. Often, this promotes h

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Vishakha, Shinde* Gayatri Dalvi Trupti Shinde. "Nanomedicine Drug Delivery System." International Journal of Scientific Research and Technology 1, no. 11 (2024): 51–58. https://doi.org/10.5281/zenodo.14160347.

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Nanomedicine and Nano delivery systems are a relatively new but rapidly developing science where materials in the nanoscale range are employed to serve as means of diagnostic tools or to deliver therapeutic agents to specific targeted sites in a controlled manner. Nanotechnology offers multiple benefits in treating chronic human diseases by site-specific, and target-oriented delivery of precise medicines. Drug delivery to certain target cells is now available by using nanoparticles via nanotechnology, Biomedical nanomaterials are used in vivo and in vitro in the clinical researches, because of

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22

Arpit, Rajaram Suralkar, Shahaji Khedkar Chaitanya, R. Zanwar Nidhi, C. Chandak Chanchal, and J. Gandhi Shital. "Liposomes as a novel drug delivery system." GSC Biological and Pharmaceutical Sciences 20, no. 3 (2022): 336–43. https://doi.org/10.5281/zenodo.7328933.

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Liposome is a microparticulate colloidal vesicle, in which aqueous medium is surrounded by single or multiple concentric layers of phospholipids. Both hydrophilic & hydrophobic drug can be incorporated, water soluble drug being trapped in aqueous core and fat soluble drug in phospholipids. It offers controlled release, targeted drug delivery thus enhanced therapeutic efficacy and reduced dosing frequency. Several liposome based drug formulation are approved for clinical use and many are under extensive investigation. Therapeutically, these are used as carrier for drugs, viruses, bacteria,

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Manisha, Rokade* Pradnya Khandagale Dr. Vivek Bhyahatti. "A Review on Development of Transdermal Drug Delivery System." International Journal of Pharmaceutical Sciences 3, no. 2 (2025): 1757–68. https://doi.org/10.5281/zenodo.14901780.

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A transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream. Often, this promotes healing to an injured area of the body. An advantage of a transdermal drug delivery route over other types of medication delivery such as oral, topical, intravenous, intramuscular, etc. is that the patch provides a controlled release of the medication into the patient, usually through either a porous membrane covering a reservoir of medication or through body heat melting thin layers of medication embedded in the a

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Thakur, Sanjay, Krishnappa Ramya, Deepak Kumar Shah, and Khadga Raj. "Floating Drug Delivery System." Journal of Drug Delivery and Therapeutics 11, no. 3-S (2021): 125–30. http://dx.doi.org/10.22270/jddt.v11i3-s.4828.

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Floating drug delivery system (FDDS) helps to improve the buoyancy property of the drug over the gastric fluids and hence maintain the longer duration of action. It is helpful in minimizing the dosing frequency. The density of dosage form must be less than the density of gastric contents (1.004 gm/ml) in FDDS. It may effervescent or non-effervescent system. The drugs having narrow absorption window in GIT is good candidate for the floating drug delivery system. The main objective of writing this review article is to compile the recent literature with special focus on classification, method of

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Shivanand, Padmaja, and Omar L. Sprockel. "A controlled porosity drug delivery system." International Journal of Pharmaceutics 167, no. 1-2 (1998): 83–96. http://dx.doi.org/10.1016/s0378-5173(98)00047-7.

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Narinder, Singh* Pooja Devi Muskan Sharma Naval Singh. "Novel Drug Delivery System." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 434–46. https://doi.org/10.5281/zenodo.15334655.

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The advancement of pharmaceutical sciences has led to the development of various novel drug delivery systems (NDDS) that improve the efficacy, safety, and patient compliance of therapeutic agents. Traditional drug administration methods often encounter challenges such as poor bioavailability, non-specific distribution, and the need for frequent dosing. To overcome these limitations, several innovative approaches have been explored. Transdermal drug delivery systems (TDDS) allow for sustained drug release through the skin, bypassing first-pass metabolism. Vesicular drug delivery systems (VDDS),

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Shraddha, Prashant Dhamapurkar, and Mahendra Desai Deepa. "A review on microsphere for novel drug delivery system." World Journal of Advanced Research and Reviews 16, no. 3 (2022): 529–38. https://doi.org/10.5281/zenodo.7902920.

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Microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers which are biodegradable in nature and ideally having a particle size less than 200 µm. A well designed controlled drug delivery system can overcome some of the problems of conventional therapy and enhance the therapeutic efficacy of a given drug. There are various approaches in delivering a therapeutic substance to the target site in a sustained controlled release fashion. One such approach is using microspheres as carriers for drugs. It is the reliable means to deliver the drug to the t

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Ravi, Silpa C., K. Krishnakumar, and Smitha K. Nair. "Nano sponges: A targeted drug delivery system and its applications." GSC Biological and Pharmaceutical Sciences 7, no. 3 (2019): 040–47. https://doi.org/10.5281/zenodo.4286077.

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The recent innovative advance in nanotechnology has led to the development of targeted drug delivery system. Targeting a molecule to a particular site with the help of a drug delivery system efficiently requires the use of specialized drug delivery systems. The invention of Nano sponges has become a significant step in overcoming the problems associated with conventional drug delivery systems. These are able to carry both hydrophilic and hydrophobic drugs. Nano sponge technology widely provide the controlled and predictable release of the drug to the targeted site. The Nano sponge particles ci

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Ma, Zhiyuan, Baicheng Li, Jie Peng, and Dan Gao. "Recent Development of Drug Delivery Systems through Microfluidics: From Synthesis to Evaluation." Pharmaceutics 14, no. 2 (2022): 434. http://dx.doi.org/10.3390/pharmaceutics14020434.

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Conventional drug administration usually faces the problems of degradation and rapid excretion when crossing many biological barriers, leading to only a small amount of drugs arriving at pathological sites. Therapeutic drugs delivered by drug delivery systems to the target sites in a controlled manner greatly enhance drug efficacy, bioavailability, and pharmacokinetics with minimal side effects. Due to the distinct advantages of microfluidic techniques, microfluidic setups provide a powerful tool for controlled synthesis of drug delivery systems, precisely controlled drug release, and real-tim

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Mohammad, Shoaib Shaikh Hamid, R. Hatwar Pooja, L. Bakal Ravindrakumar, and B. Kohale Nitin. "A comprehensive review on Liposomes: As a novel drug delivery system." GSC Biological and Pharmaceutical Sciences 27, no. 1 (2024): 199–210. https://doi.org/10.5281/zenodo.11974168.

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Liposomes, as versatile lipid-based nanoparticles, have emerged as promising drug delivery systems in recent years. This comprehensive review aims to provide an in-depth analysis of the advancements, challenges, and potential applications of liposomes in drug delivery. The review covers various aspects of liposome-based drug delivery, including their structure, formulation methods, advantages, limitations, and recent breakthroughs in the field. Furthermore, we discuss the diverse range of drugs and therapeutic agents that can be encapsulated within liposomes, as well as their clinical applicat

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Nalawade, Vishwajit, and Kunal Patil. "Liposome: A Novel Drug Delivery System." International Journal of Research Publication and Reviews 04, no. 01 (2022): 1795–801. http://dx.doi.org/10.55248/gengpi.2023.4148.

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Liposome was derived from two Greek words “Lipos meaning fat and Soma meaning body”. Liposome were spherical shaped vesicles consist of phospholipids and cholesterol. Due to their size hydrophobic and lipophilic character they are very promising system for drug delivery. This novel drug delivery system aims to target the drug directly to the site of action. Liposomes are very biocompatible and stable and have unique property to entrap both hydrophilic drug and lipophilic drug to its compartment and lead to controlled release effect. They are of 0.05- 5.0 micrometer in diameter. Liposomes are u

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N., Shiva Krishna* Dr. B. Jayanthi A. Madhukar. "A REVIEW OF PULSATILE DRUG DELIVERY SYSTEM." Indo American Journal of Pharmaceutical Sciences 05, no. 06 (2018): 5488–94. https://doi.org/10.5281/zenodo.1296981.

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<em>Pulsatile drug delivery systems are gaining importance in the field of pharmaceutical technology as these systems deliver the right dose at specific time at a specific site.the product follow a sigmoidal drug release profile characterized by a time period of no release (lag time) followed by a rapid and complete drug release. diseases where in chronopharmaceutics are promising include asthma,peptic ulcers, cardiovascular diseases, arthritis, neurological disorders and hypercholesterolemia etc. various capsular, osmotic, single and multiple unit systems that are modulated by soluble (or) er

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Dhamore, Harshada Gorakh, Assist Prof Kalpana S. Kale, and Dr Megha Salve. "Liposomal Drug Delivery System." International Journal of Pharmaceutical Research and Applications 09, no. 06 (2024): 502–9. https://doi.org/10.35629/4494-0906502509.

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Liposomes have been considered promising and versatile drug vesicles. Compared with traditional drug delivery systems, liposomes exhibit better properties, including site-targeting, sustained or controlled release, protection of drugs from degradation and clearance, superior therapeutic effects, and lower toxic side effects. Given these merits, several liposomal drug products have been successfully approved and used in clinics over the last couple of decades. In this review, the liposomal drug products approved by the U.S. Food and Drug Administration (FDA) and European Medicines. Agency (EMA)

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Prof., Madhuri T. Deshmukh Harshada A. Lawale *. Prof. R.V. Shete Prof. R.S. Solunke. "A REVIEW ON TRANSDERMAL DRUG DELIVERY SYSTEM." Journal of Pharma Research 7, no. 12 (2018): 279–82. https://doi.org/10.5281/zenodo.2085047.

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<strong><em>ABSTRACT</em></strong> <strong><em>R</em></strong><em>ecently delivery of drugs through the skin is being a challenging area for research because of barrier properties exhibit    by the outermost layer of skin stratum corneum. The transdermal drug delivery system has offers significant clinical benefits over other dosage forms. Because transdermal drug delivery offers controlled and predetermined rate of release of the drug into the patient, it able to maintain steady state blood concentration in blood stream. It is essential form of drug delivery due to absolute adv

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Shraddha Prashant Dhamapurkar and Deepa Mahendra Desai. "A review on microsphere for novel drug delivery system." World Journal of Advanced Research and Reviews 16, no. 3 (2022): 529–38. http://dx.doi.org/10.30574/wjarr.2022.16.3.1368.

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Microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers which are biodegradable in nature and ideally having a particle size less than 200 µm. A well designed controlled drug delivery system can overcome some of the problems of conventional therapy and enhance the therapeutic efficacy of a given drug. There are various approaches in delivering a therapeutic substance to the target site in a sustained controlled release fashion. One such approach is using microspheres as carriers for drugs. It is the reliable means to deliver the drug to the target

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Akram, Wasim, Ramakant Joshi, and Navneet Garud. "Inulin: A promising carrier for controlled and targeted drug delivery system." Journal of Drug Delivery and Therapeutics 9, no. 1-s (2019): 437–41. http://dx.doi.org/10.22270/jddt.v9i1-s.2398.

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The delivery of a drug to the preferred site of action is referred to as drug targeting. The benefits of drug targeting are a reproducible and controlled release rate of the therapeutic compound, which forestalls overdose. Due to the potential to treat colonic diseases with minimum side effects, colon targeting has become of high interest over the last decades. Inulin was investigated for its potential as encapsulation material regarding its enzymatic degradability and its drug release behaviour. Inulin is a polysaccharide with a widespread range of therapeutic uses such as a carrier in a drug

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Kocemba, Aleksandra, and Maria Mucha. "CHITOSAN/POLY(VINYL ALCOHOL) HYDROGELS AS CONTROLLED DRUG DELIVERY SYSTEMS." Progress on Chemistry and Application of Chitin and its Derivatives XXII (September 30, 2017): 97–105. http://dx.doi.org/10.15259/pcacd.22.09.

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Sadab, Sadab, Sarad Sahu, Shubham Patel, et al. "A Comprehensive Review: Transdermal Drug Delivery System: A Tool For Novel Drug Delivery System." Asian Journal of Dental and Health Sciences 2, no. 4 (2022): 40–47. http://dx.doi.org/10.22270/ajdhs.v2i4.24.

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In the recent decade, skin delivery (topical and transdermal) has gained an unprecedented popularity, especially due to increased incidences of chronic skin diseases, demand for targeted and patient compliant delivery and interest in life cycle management strategies among pharmaceutical companies. Transdermal drug delivery system was presented to overcome the difficulties of drug delivery especially oral route. Transdermal drug delivery refers to a means of delivering drugs through the surface of the skin for local or systemic treatment. The drug functions after absorption through the skin int

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Siddhant Ashruba, Mundhe, and Dr V. M. .Satpute. "An Overview: Transdermal Drug Delivery System (TDDS)." INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT 09, no. 04 (2025): 1–9. https://doi.org/10.55041/ijsrem44545.

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Transdermal drugs have made an important contribution to pharmaceutical dosage forms, nevertheless have yet to fully accomplish its potential as an alternative to oral dosage form and hypodermic injections. A transdermal drug delivery system (TDDS) represents the most attractive method among these because of its low rejection rate, excellent ease of administration, and superb convenience and persistence among patients. A transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream.Transdermal drug

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Arpit Rajaram Suralkar, Chaitanya Shahaji Khedkar, Nidhi R Zanwar, Chanchal C Chandak, and Shital J Gandhi. "Liposomes as a novel drug delivery system." GSC Biological and Pharmaceutical Sciences 20, no. 3 (2022): 336–43. http://dx.doi.org/10.30574/gscbps.2022.20.3.0372.

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Liposome is a microparticulate colloidal vesicle, in which aqueous medium is surrounded by single or multiple concentric layers of phospholipids. Both hydrophilic & hydrophobic drug can be incorporated, water soluble drug being trapped in aqueous core and fat soluble drug in phospholipids. It offers controlled release, targeted drug delivery thus enhanced therapeutic efficacy and reduced dosing frequency. Several liposome based drug formulation are approved for clinical use and many are under extensive investigation. Therapeutically, these are used as carrier for drugs, viruses, bacteria,

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Akshata, V. Raut* Nakul Kathar Ganjanan Sanap. "Microsponges: The Drug Delivery System." International Journal in Pharmaceutical Sciences 2, no. 1 (2024): 328–41. https://doi.org/10.5281/zenodo.10523750.

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Microsponge technology has been developed for topical drug products in order to promote controlled release of the drug's active ingredient into the skin, thereby reducing systemic exposure and minimizing local cutaneous reactions to active drugs. Microsponge is made up of macroporous beads that are normally 10-25 micron in diameter and loaded with an active agent. When applied to the skin, the microsponge releases its active ingredients on a timer as well as in response to other signals. Microsponge drug delivery technology holds great promise for achieving the goal of controlled and site-spec

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Aarti, Nimse* Dr. Sachin Kale Rutuja Giram Ashvini Kakad. "A Comprehensive Review on Liposomes: As A Novel Drug Delivery System." International Journal of Pharmaceutical Sciences 2, no. 12 (2024): 3476–87. https://doi.org/10.5281/zenodo.14582120.

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This review explores the potential applications of liposomes as a drug delivery system, focusing on their structure, formulation methods, advantages, limitations, and recent breakthroughs. It also discusses the diverse range of drugs and therapeutic agents that can be encapsulated within liposomes and their clinical applications in targeting specific diseases. The review provides an in-depth analysis of liposome-based drug delivery.

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Mondal, Nita. "THE ROLE OF MATRIX TABLET IN DRUG DELIVERY SYSTEM." International Journal of Applied Pharmaceutics 10, no. 1 (2018): 1. http://dx.doi.org/10.22159//ijap.2018v10i1.21935.

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Matrix tablet is an important tool for controlled and sustained release dosage forms. The oral route remains the most common route for the administration of drugs. Tablets offer the lowest cost approach to sustained and controlled release dosage forms. The hydrophilic polymer matrix is widely used in this dosage form. The use of different polymers in controlling the release of drugs has become the most important tool in the formulation of matrix tablets. The drug releases by both dissolution-controlled as well as diffusion-controlled mechanisms from the matrix. The development of oral controll

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Akhilesh, Kumar, Shafaat Kausar, Kumar Singh Bimlendra, et al. "pH Sensitive Hydrogel Based Controlled Drug Delivery System for Oral Delivery of Famotidine." Pharmaceutical and Chemical Journal 12, no. 2 (2025): 22–33. https://doi.org/10.5281/zenodo.15606206.

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Improving the safety efficacy ratio of existing drugs is a current challenge to be addressed rather than the development of novel drugs which involve much expense and time. The efficacy of drugs is affected by a number of factors such as their low aqueous solubility, unequal absorption along the gastrointestinal (GI) tract, risk of degradation in the acidic milieu of the stomach, low permeation of the drugs in the upper GI tract, systematic side effects, etc. A new pH responsive drug delivery system based on inter-polymeric hydrogels was developed for oral drug delivery of famotidine, the effe

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K, Dudhat. "An Insight to Modified Release Dosage Form with Osmotic Drug Delivery System." Bioequivalence & Bioavailability International Journal 7, no. 1 (2023): 1–4. http://dx.doi.org/10.23880/beba-16000193.

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Osmotic drug delivery is a technique for managing the controlled, prolonged release of medications. A semi-permeable membrane is used to separate two compartments, one of which contains the medicine and the other of which contains an osmotic agent, in the system, which is based on the osmosis principle. The medicine is pushed through the membrane at a controlled rate thanks to the pressure differential created when the osmotic agent sucks water from the body into the drug compartment. The system can be set up to disperse medications over long periods of time, from a few hours to several months

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Srinu, K., and S. Sravani. "A Review on Gastroretentive Drug Delivery System." International Journal for Research in Applied Science and Engineering Technology 12, no. 11 (2024): 2084–88. http://dx.doi.org/10.22214/ijraset.2024.65547.

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Abstract: Day by day the topic GRDDS has becoming popular due to its good therapeutic values and ease of cost of manufacturing. Gastro retentive drug delivery system is a type of retentive system it means which holds the drugs for prolonged time in GI fluid and release the drug in a controlled manner. And this article explores significance of GRDDS and its advantages over conventional system. This also focuses on the anatomy of stomach, introduction to GRDDS, criteria for selection of drug candidate for GRDDS, technologies of GRDDS. Keywords: Gastro-retentive, Controlled release , Site-specifi

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panwar, Asha, Sakshi Singh, and Dr Himadri Dr. Himadri. "A Review on Formulation Development of Bilayer Floating Tablet." International Journal of Pharmaceutical Research and Applications 10, no. 1 (2025): 1406–10. https://doi.org/10.35629/4494-100114061410.

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In the recent past, controlled release concept and technology have received increasing attention in the face of growing awareness to toxicity and ineffectiveness of drugs when administered or applied by conventional methods. Thus drugs applied in the form of tablets, capsules, injectables and ointments etc., usually produce wide range of fluctuations in drug concentration in the blood stream and tissues with consequent undesirable toxicity and poor efficiency. This factor as well such as repetitive dosing and unpredictable absorption led to the concept of controlled drug delivery systems or th

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Abhay, S. Jejurkar* Angad B. Newre Akash B. Ravate Abhishek S. Wakle Dr. Rajendra M. Kawade. "Niosomes: Pharmaceutical Novel Drug Delivery System." International Journal in Pharmaceutical Sciences 1, no. 11 (2023): 18–24. https://doi.org/10.5281/zenodo.10060583.

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Niosome is an innovative drug delivery system designed to address the challenges associated with conventional drug administration methods. This system employs advanced nanotechnology to encapsulate pharmaceutical compounds within lipid-based nanovesicles, known as niosomes. Niosomes offer several advantages, including enhanced drug stability, controlled release, and improved bioavailability. This technology holds great promise for improving the efficacy and safety of various drugs, leading to better patient outcomes. This abstract provides a glimpse into the potential of neosomes as a groundbr

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Farhan, Shaikh* Ahish Sawant Rahul Mane Tushar Bansode Shamir Tamboli Priyanka Khadsare. "Bioresponsive Drug Delivery System (Sonoporation)." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 5190–200. https://doi.org/10.5281/zenodo.15562991.

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Bioresponsive drug delivery systems represent an ideal approach in targeted therapeutic system, offering precise control over drug release in response to specific biological stimuli, such as pH, redox gradients, or enzymatic activity. These systems are especially in the treatment of cancer, cardiovascular diseases, and chronic inflammatory conditions etc where spatial and temporal control of drug release can significantly improve therapeutic outcomes. Sonoporation, a technique which use ultrasound waves to create temporary pores in the cellular membrane, that shows enhancement to the delivery

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Adepu, Shivakalyani, and Seeram Ramakrishna. "Controlled Drug Delivery Systems: Current Status and Future Directions." Molecules 26, no. 19 (2021): 5905. http://dx.doi.org/10.3390/molecules26195905.

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The drug delivery system enables the release of the active pharmaceutical ingredient to achieve a desired therapeutic response. Conventional drug delivery systems (tablets, capsules, syrups, ointments, etc.) suffer from poor bioavailability and fluctuations in plasma drug level and are unable to achieve sustained release. Without an efficient delivery mechanism, the whole therapeutic process can be rendered useless. Moreover, the drug has to be delivered at a specified controlled rate and at the target site as precisely as possible to achieve maximum efficacy and safety. Controlled drug delive

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