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Journal articles on the topic 'Controlled release technology'

Author: Grafiati

Published: 4 June 2021

Last updated: 29 January 2023

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1

Peppas, N. A. "Controlled-release technology: Pharmaceutical applications." Journal of Controlled Release 7, no. 2 (1988): 186. http://dx.doi.org/10.1016/0168-3659(88)90014-4.

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2

Brannon, M. Lisa. "Controlled release technology: Pharmaceutical applications." Journal of Controlled Release 7, no. 3 (1988): 289. http://dx.doi.org/10.1016/0168-3659(88)90068-5.

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3

Tabata, Yasuhiko. "Controlled Release Technology to Support Advanced Medicine." Drug Delivery System 31, no. 3 (2016): 219–27. http://dx.doi.org/10.2745/dds.31.219.

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4

McElnay, J. C. "Pharmaceutical technology. Controlled drug release, vol. 1." Endeavour 12, no. 2 (1988): 95. http://dx.doi.org/10.1016/0160-9327(88)90112-3.

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5

Agrawala, Praful, and Praveen Tyle. "Pharmaceutical Technology: Controlled Drug Release. Volume 1." Journal of Pharmaceutical Sciences 77, no. 6 (1988): 557–58. http://dx.doi.org/10.1002/jps.2600770622.

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6

Awad, Atheer, Fabrizio Fina, Sarah Trenfield, et al. "3D Printed Pellets (Miniprintlets): A Novel, Multi-Drug, Controlled Release Platform Technology." Pharmaceutics 11, no. 4 (2019): 148. http://dx.doi.org/10.3390/pharmaceutics11040148.

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Selective laser sintering (SLS) is a single-step three-dimensional printing (3DP) process that can be leveraged to engineer a wide array of drug delivery systems. The aim of this work was to utilise SLS 3DP, for the first time, to produce small oral dosage forms with modified release properties. As such, paracetamol-loaded 3D printed multiparticulates, termed miniprintlets, were fabricated in 1 mm and 2 mm diameters. Despite their large surface area compared with a conventional monolithic tablet, the ethyl cellulose-based miniprintlets exhibited prolonged drug release patterns. The possibility

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7

Jo, Jun-Ichiro, and Yasuhiko Tabata. "How controlled release technology can aid gene delivery." Expert Opinion on Drug Delivery 12, no. 10 (2015): 1689–701. http://dx.doi.org/10.1517/17425247.2015.1048221.

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8

Ogueri, Kenneth S., and Sheri L. Shamblin. "Osmotic-controlled release oral tablets: technology and functional insights." Trends in Biotechnology 40, no. 5 (2022): 606–19. http://dx.doi.org/10.1016/j.tibtech.2021.10.001.

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9

Song, Z. "Chemiluminescence sensor for isoniazid with controlled-reagent-release technology." Talanta 53, no. 6 (2001): 1171–77. http://dx.doi.org/10.1016/s0039-9140(00)00609-3.

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10

NIZAMI, FARIDA, and YOGENDRA MALVIYA. "RECENT ADVANCEMENT AND CHALLENGES IN BILAYER TABLET TECHNOLOGY: AN OVERVIEW." Current Research in Pharmaceutical Sciences 11, no. 4 (2022): 91–97. http://dx.doi.org/10.24092/crps.2021.110401.

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Bilayer tablets were developed recently for the effective production of controlled release formulations in various quality levels to give a method of successful drug delivery. Over the last three decades, as the cost and complexity of developing novel pharmacological entities have increased and as the therapeutic benefits of controlled drug administration have been recognized, considerable attention has been focused on developing sustained or controlled release drug delivery systems. It is utilized to produce a variety of antihypertensive formulations. Bilayer tablets allow for the predetermin

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11

Kushibiki, T., K. Matsumoto, T. Nakamura, and Yasuhiko Tabata. "Controlled Release Technology Suppresses the Progression of Disseminated Pancreatic Cancer Cells." Key Engineering Materials 288-289 (June 2005): 121–24. http://dx.doi.org/10.4028/www.scientific.net/kem.288-289.121.

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NK4, composed of the NH2-terminal hairpin and subsequent four-kringle domains of hepatocyte growth factor (HGF), acts as a potent angiogenesis inhibitor. This study is an investigation to evaluate the feasibility of controlled release of NK4 plasmid DNA in suppressing tumor growth. Controlled release by a biodegradable hydrogel enabled the NK4 plasmid DNA to enhance the tumor suppression effects. Biodegradable microspheres of cationized gelatin were prepared for the controlled release of a NK4 plasmid DNA. The cationized gelatin microspheres incorporating NK4 plasmid DNA were subcutaneously in

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12

Rajput, Rajesh, K. M. K. Prasanna Kumar, D. S. Arya, et al. "Osmotic controlled drug delivery system (OSMO technology) and its impact on diabetes care." International Journal of Research in Medical Sciences 9, no. 1 (2020): 303. http://dx.doi.org/10.18203/2320-6012.ijrms20205861.

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Recently, focus on the development of controlled release drug delivery system has increased, as existing drugs exhibit certain pharmacokinetic limitations. The major goal of designing sustained release formulations is to improve the drug performance by prolonged duration of drug action, decreased frequency of dosing and reduced side effects by using smallest quantity of drug administered by the most suitable route. Osmotic-controlled release oral delivery system (OSMO technology) is the most promising strategy based system for sustained delivery of drug. Drug can be delivered in a controlled m

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13

Hussein, Mayssam, and Israa Nathir. "Pulsatile Drug Delivery System Utilizing Innovative Technology." Pakistan Journal of Medical and Health Sciences 16, no. 6 (2022): 601–6. http://dx.doi.org/10.53350/pjmhs22166601.

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Drugs might be released immediately or over time. Pulsatile medication release systems, on the other hand, have been increasing in popularity in recent years. Many medications or therapies could benefit from pulsatile drug release, in which the drug is released rapidly after a predetermined lag time. Pulsatile release systems come in pairs: multi and separate pulse. Rupturable dose forms are a prominent type of single-pulse device. Other methods have a drug-containing centre covered by both a swelling surface and a semi - permeable barrier polymer layer or membrane that is semipermeable but no

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14

Mirth, D. B. "Controlled-Release Therapeutic Systems: Technology Applicable To the Treatment of Oral Disease." Advances in Dental Research 1, no. 1 (1987): 109–18. http://dx.doi.org/10.1177/08959374870010010201.

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Controlled-release therapeutic systems are designed to deliver a pre-determined amount of drug to a specific anatomical site for an extended period of time. A single controlled-release delivery system no larger than an ordinary tablet or capsule and placed at the desired site of drug action can produce long-term therapeutic effects that previously could only be achieved through multiple administration of conventional dosage forms. Transient spikes in drug concentration seen with multiple dose regimens are eliminated, decreasing the chance of adverse reactions. Because they are effective for an

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15

Kushibiki, Toshihiro, and Yasuhiko Tabata. "A New Gene Delivery System Based on Controlled Release Technology." Current Drug Delivery 1, no. 2 (2004): 153–63. http://dx.doi.org/10.2174/1567201043479948.

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16

Howard, Stephen A., and David E. Wallick. "Editorial—Theme issue on oral controlled release development and technology." AAPS PharmSciTech 6, no. 4 (2005): E633. http://dx.doi.org/10.1208/pt060478.

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17

Cleland, J. "Single-administration vaccines: controlled-release technology to mimic repeated immunizations." Trends in Biotechnology 17, no. 1 (1999): 25–29. http://dx.doi.org/10.1016/s0167-7799(98)01272-4.

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18

Anderson, N. "Controlled release technology for the control of helminths in ruminants." Veterinary Parasitology 18, no. 1 (1985): 59–66. http://dx.doi.org/10.1016/0304-4017(85)90008-1.

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19

Islam, Muhammad Rashedul, Md Elias Al Mamun, Md Mizanur Rahman Moghal, and Md Habibur Rahman. "Development and Evaluation of Indomethacin Controlled Release Press Coated Tablets." Dhaka University Journal of Pharmaceutical Sciences 14, no. 2 (2016): 187–92. http://dx.doi.org/10.3329/dujps.v14i2.28509.

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In the present work, several batches of indomethacin press coated tablets were prepared with drug and Avicel PH 102 utilizing the press coating technology. The core tablet was compression coated with minimal compression pressure. The compression coating mixture was formulated using various amount of lactose and xanthan gum which was used as the release retarding agent. Three formulations (IX-1, IX-2 and IX-3) were designed to evaluate the release profile as function of xanthan gum load. In vitro drug release testing demonstrated that the drug release was inversely proportional to the amount of

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20

Xiong, Houfeng, Mingxin Huo, Dandan Zhou, Shuangshi Dong, and Donglei Zou. "Characteristics and kinetics simulation of controlled-release KMnO4 for phenol remediation." Water Science and Technology 74, no. 3 (2016): 647–54. http://dx.doi.org/10.2166/wst.2016.233.

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Controlled-release KMnO4 (CRP) technology has been recently developed as an improved, highly efficient technique in wastewater treatment. In this study, batch-style experiments were conducted to evaluate this technology. The release characteristics of CRP in distilled water and the reaction between CRP and phenol were studied and fitted using MATLAB software. Results indicated that in distilled water, temperature (T) and pH value had a larger effect than dissolved oxygen (DO) concentration on the release characteristics of KMnO4, and this relationship can be accurately described by the followi

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21

Cohen, Smadar, Maria J. Alonso, and Robert Langer. "Novel Approaches to Controlled-Release Antigen Delivery." International Journal of Technology Assessment in Health Care 10, no. 1 (1994): 121–30. http://dx.doi.org/10.1017/s0266462300014045.

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AbstractTwo strategies for vaccine-delivery systems, both relying on concepts of controlled-release technology, are described in this review. The first strategy involves using biodegradable polymer microspheres for parenteral and oral delivery of antigens. The other strategy combines two technologies, the encapsulation of antigen within liposomes and liposome encapsulation in hydrogels, to protect them from a rapid degradation in vivo. Both strategies have shown promise in terms of increasing the immunogenicity of poorly immunogenic peptides and protein vaccines. The microencapsulation process

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22

Attard, P., and J. Micallef. "Ion current combustion technology for controlled auto-ignition gasoline engines." International Journal of Engine Research 8, no. 5 (2007): 429–37. http://dx.doi.org/10.1243/14680874jer03604.

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The use of ionization sensors, by means of a standard spark plug, in gasoline engines is well known. This paper focuses on the use of these sensors for controlled auto-ignition (CAI) gasoline engines, where the air-fuel mixture ignites without the need of a spark. The averaged ion current signals obtained are first observed and compared to the heat release rate and then a method to detect with accuracy the location of the 50 per cent mass fraction burned is described. The variation of emissions is studied and the effects of using a pressure sensor (to calculate the heat release rate) or an ion

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23

Rathbone, Michael John. "Delivering drugs to farmed animals using controlled release science and technology." International e-Journal of Science, Medicine & Education 6, Suppl1 (2012): S118—S128. http://dx.doi.org/10.56026/imu.6.suppl1.s118.

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24

Simkiss, K. "The application of controlled release and QSAR technology to sediment toxicity." Marine Pollution Bulletin 31, no. 1-3 (1995): 28–31. http://dx.doi.org/10.1016/0025-326x(95)00004-7.

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25

Tang, Yingying, Huan Teng, Yanan Shi, et al. "Tablets of paliperidone using compression-coated technology for controlled ascending release." Asian Journal of Pharmaceutical Sciences 13, no. 2 (2018): 143–54. http://dx.doi.org/10.1016/j.ajps.2017.09.005.

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26

Della Porta, Giovanna, Maria C. Ciardulli, and Nicola Maffulli. "Microcapsule Technology for Controlled Growth Factor Release in Musculoskeletal Tissue Engineering." Sports Medicine and Arthroscopy Review 26, no. 2 (2018): e2-e9. http://dx.doi.org/10.1097/jsa.0000000000000188.

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27

Son, A. V., and V. A. Vainshtein. "Development of the Composition and Technology for Controlled-Release Lornoxicam Tablets." Pharmaceutical Chemistry Journal 48, no. 1 (2014): 51–56. http://dx.doi.org/10.1007/s11094-014-1045-3.

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28

Mohammad, Abdul Saleem, Seema Farheen, and Nuha Rasheed. "Formulation and Evaluation of Trilayered Tablets of Zolmitriptan." International Journal of Pharmaceutical Sciences and Nanotechnology 9, no. 6 (2016): 3512–23. http://dx.doi.org/10.37285/ijpsn.2016.9.6.1.

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The present study outlines a systematic approach to formulate and evaluate trilayered tablets of zolmitriptan by geomatrix technology by using different concentrations of HPMC, xanthangum and ethyl cellulose by direct compression method for controlled release, which may produce the controlled drug release in the treatment of migraine disorder. The different release rates from these formulations were obtained from in vitro dissolution studies. From the results it was observed that the release rate was greatly influenced by the polymer concentration. In order to obtain a formulation which releas

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29

Li, Li, Zhou Zheng Zhou, Zhen Li, and CH X. Wu. "Controlled Drug Release Using Nanoporous Alumina Capsules." Key Engineering Materials 361-363 (November 2007): 1223–26. http://dx.doi.org/10.4028/www.scientific.net/kem.361-363.1223.

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Nano-materials and technology increasingly come under emphasis on application in biomedical treatment and pharmaceutical field. Drug particle with nano-size has better bioactivity and absorptivity, which advance the efficiency of utilization. The nanoporous alumina membranes fabricated by anodization are provided with orderd nanoporous structure, highly uniform pore size, straight and parallel pore channels, moreover, this material possesses favorable biocompatibility. Recently, application of nanoporous alumina membranes in medical science has becoming public concerned in present biomedical m

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30

Tian, Zhen, Nai Ci Bing, Ye Zhang, Ling Ling Wang, and Wei Qiao. "Supercritical Solvent Impregnation in Controlled-Release Drugs." Advanced Materials Research 152-153 (October 2010): 1462–65. http://dx.doi.org/10.4028/www.scientific.net/amr.152-153.1462.

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In the field of pharmaceutical industry, the controlled-release drugs have received considerable attention in the last years. Impregnation using supercritical fluid technology has already proven its feasibility in the preparation of controlled release systems. The use of supercritical fluids such as supercritical CO2 has provided a ‘clean’ and effective alternative to traditional methods of drug releasing and polymer processes. In particular, scCO2 has a number of unique properties that make it possible to process both bioactive molecules and amorphous polymers without using toxic organic solv

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31

Tian, Miao Miao, Yan Hua Cao, Rui Nan Jiang, Bao Lin Zhu, and Gui Xiang Ling. "Research on Controlled Release Technology of the Anti-Icing Modifier in Asphalt Mixture." Advanced Materials Research 1049-1050 (October 2014): 309–15. http://dx.doi.org/10.4028/www.scientific.net/amr.1049-1050.309.

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The agent with a function of controlling the release rate of the anti-icing modifier used in the asphalt mixture was researched in this paper. The purpose is to make the salt components’ release rate controllable and extend the usage life of the anti-icing modifier. Apply the “Rapid Determination of Chloride Ion Content Instrument” to assess the release rate of the different agents. Research and analyze the impact on the anti-icing modifier’s durability brought by the different agents.

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32

Weisman, Gary R., Donald C. Sundberg, Robert A. Cimini, Melanie G. Brown, Brett R. Beno, and T. Taylor Eighmy. "Controlled release antifouling coatings. I. approaches for controlled release of 2,4‐dinitrophenolate and benzoate into seawater." Biofouling 6, no. 2 (1992): 123–46. http://dx.doi.org/10.1080/08927019209386218.

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33

Li, Song, Wengang Li, and Niveen M. Khashab. "Stimuli responsive nanomaterials for controlled release applications." Nanotechnology Reviews 1, no. 6 (2012): 493–513. http://dx.doi.org/10.1515/ntrev-2012-0033.

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AbstractThe controlled release of therapeutics has been one of the major challenges for scientists and engineers during the past three decades. Coupled with excellent biocompatibility profiles, various nanomaterials have showed great promise for biomedical applications. Stimuli-responsive nanomaterials guarantee the controlled release of cargo to a given location, at a specific time, and with an accurate amount. In this review, we have combined the major stimuli that are currently used to achieve the ultimate goal of controlled and targeted release by “smart” nanomaterials. The most heavily ex

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34

Kotsur, Julia M., and Elena V. Flisyuk. "Modern polymers in prolonged release tablet technology." Pharmacy Formulas 2, no. 1 (2020): 36–43. http://dx.doi.org/10.17816/phf21267.

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Currently, the delivery systems of second and third generation are of particular interest among pharmaceutical forms. Second generation pharmaceutical forms include systems with prolonged release of the active substance, third generation pharmaceutical forms include systems with controlled release. A slow continuous release of a medicinal substance may be achieved by using special excipients or by using special technologies. For the production of tablets with prolonged release, the most common are special excipients, namely, polymers and their compositions. The use of polymers as c

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35

Gerogiannis, V. S., D. M. Rekkas, P. P. Dallas, and N. H. Choulis. "Floating and Swelling Characteristics of Various Excipients Used in Controlled Release Technology." Drug Development and Industrial Pharmacy 19, no. 9 (1993): 1061–81. http://dx.doi.org/10.3109/03639049309063001.

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36

Avalle, P., M. J. Pollitt, K. Bradley, et al. "Development of Process Analytical Technology (PAT) methods for controlled release pellet coating." European Journal of Pharmaceutics and Biopharmaceutics 87, no. 2 (2014): 244–51. http://dx.doi.org/10.1016/j.ejpb.2014.01.008.

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37

Liu, Qiang, Haifeng Liu, and Yubo Fan. "Preparation of silk fibroin carriers for controlled release." Microscopy Research and Technique 80, no. 3 (2015): 312–20. http://dx.doi.org/10.1002/jemt.22606.

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38

Karimi Afshar, Sepideh, Mohammadmohsen Abdorashidi, Farid Abedin Dorkoosh, and Hamid Akbari Javar. "Electrospun Fibers: Versatile Approaches for Controlled Release Applications." International Journal of Polymer Science 2022 (October 17, 2022): 1–17. http://dx.doi.org/10.1155/2022/9116168.

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Electrospinning has been one of the most attractive methods of fiber fabrication in the last century. A lot of studies have been conducted, especially in tissue engineering and drug delivery using electrospun fibers. Loading many different drugs and bioactive agents on or within these fibers potentiates the efficacy of such systems; however, there are still no commercial products with this technology available in the market. Various methods have been developed to improve the mechanical and physicochemical behavior of structures toward more controllable delivery systems in terms of time, place,

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39

Jian, Xiumei, Minori Uchimiya, and Alexander Orlov. "Particle Size- and Crystallinity-Controlled Phosphorus Release from Biochars." Energy & Fuels 33, no. 6 (2019): 5343–51. http://dx.doi.org/10.1021/acs.energyfuels.9b00680.

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40

Yuan, Chun Ping, Hui Min Hou, Zhi Hong Cheng, Qing Hua Ge, Ding Zhong Song, and Jian Qiang Xi. "New Technology of Thermoplastic Coating for Osmotic Pump Tablets: Study on in vivo Drug Release." Pharmaceutical Fronts 02, no. 01 (2020): e1-e10. http://dx.doi.org/10.1055/s-0040-1701436.

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Abstract Aim The in vivo pharmacokinetics of thermoplastic-coated tablets prepared by a new technology of thermoplastic coating in Beagle dogs were studied, and the correlation between in vitro release and in vivo absorption was analyzed. Methods The in vitro release profiles of metformin hydrochloride thermoplastic-coated tablets and nifedipine thermoplastic-coated tablets were investigated. The single-dose pharmacokinetic study of these tablets in Beagle dogs was performed, and the obtained results were separately compared with the data of conventional osmotic pump tablets reported in the li

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41

Madiha Jabeen, Shireen Begum, Aroosa Siddique, and Syeda Saniya Fatima. "Microencapsulation: A potential and promising approach in drug delivery system." Journal of Inventions in Biomedical and Pharmaceutical Sciences 1, no. 1 (2016): 30–39. http://dx.doi.org/10.26452/jibps.v1i1.1420.

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Novel drug delivery system is a method by which drug delivered can have significant effect on its efficacy. There are several advantages of novel drug delivery system over conventional multi dose therapy, which include improved efficacy, reduced toxicity, improved patient compliance and convenience. Many efforts have been made in developing novel drug delivery system, which emphasizes on controlled and sustained release dosage forms to obtain optimum benefits. There are various approaches in delivering a therapeutic substance to the target site in a sustained controlled release fashion. One su

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42

Patel, Ravikumar, and Jayvadan Patel. "Development and evaluation of in situ novel intragastric controlled-release formulation of hydrochlorothiazide." Acta Pharmaceutica 61, no. 1 (2011): 73–82. http://dx.doi.org/10.2478/v10007-011-003-9.

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Development and evaluation of in situ novel intragastric controlled-release formulation of hydrochlorothiazide In situ forming intragastric controlled-release formulation is a new technology in the field of oral controlled-release delivery systems. The objective of this study was to develop formulations that can control drug release up to 24 hours. In addition, a combination of appropriate polymers and solvents was selected that could form a drug loaded gel at the process temperature of 60-70 °C, which gel could turn into a rigid mass upon exposure to dissolution fluid at body temperature. The

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43

Zhang, Xun, Jing Yang, Pengfei Xie, Hao Liu, Qiang Deng, and Fengwei Dai. "Experimental study on controlled-release inhibitor foam for restraining spontaneous combustion of coal." Energy Exploration & Exploitation 38, no. 4 (2020): 1159–77. http://dx.doi.org/10.1177/0144598720910266.

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A new method is proposed based on temperature-controlled self-reaction to generate and release inhibitors in the form of foam at a specific temperature, which can overcome the disadvantages of short effective time and low efficiency in the inhibition of the spontaneous combustion of coal when inhibitors are released in advance, and greatly increase the action range of inhibitor through foam diffusion. The proposed temperature-controlled foaming system was prepared with hollow spheres as solution carriers, NaHCO3 and acetic acid as basic reactants, reaction-generated CO2 as foaming gas, sodium

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44

Evaristo, Cesar, Jennifer Pankratz, Sabine Schmachtenberg, et al. "REAlease® technology: Controlled release of antibody-fluorochrome conjugates for maximal flexibility in flow sorting applications." Journal of Immunology 202, no. 1_Supplement (2019): 130.27. http://dx.doi.org/10.4049/jimmunol.202.supp.130.27.

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Abstract Multi-parameter immunofluorescent labeling is the method of choice for the flow-based sorting of targeted cell populations from heterogeneous samples. However, existing antibody-fluorochrome conjugates used for flow sorting limit the types of downstream analyses that can be applied to the isolated cells, as their continued presence on the cells blocks specific cellular epitopes and restricts the choice of downstream fluorescence detection channels. Herein, we present a new type of antibody-fluorochrome conjugates that facilitates a highly specific multi-parameter cell staining for flo

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45

Janke, Chelsea K., Ryosuke Fujinuma, Phil Moody, and Michael J. Bell. "Biochemical effects of banding limit the benefits of nitrification inhibition and controlled-release technology in the fertosphere of high N-input systems." Soil Research 57, no. 1 (2019): 28. http://dx.doi.org/10.1071/sr18211.

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Enhanced efficiency fertilisers (EEFs) may have an important role in improving nitrogen (N) use efficiency in agricultural systems. The performance of EEFs when applied by broadcasting and incorporation is well documented; however, little information is available for sub-surface banded N-fertiliser. This study aimed to determine the effectiveness of EEFs within the fertosphere in several soils. This was determined by: (i) establishing the key chemical effects and N-transformation activity within a urea band, and (ii) contrasting these findings with nitrification inhibitor (NI)-coated urea and

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46

Zhang, Xin, Mengmeng Zhang, Mingyue Wu, et al. "Precise Controlled Target Molecule Release through Light-Triggered Charge Reversal Bridged Polysilsesquioxane Nanoparticles." Polymers 13, no. 15 (2021): 2392. http://dx.doi.org/10.3390/polym13152392.

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Precise control of target molecule release time, site, and dosage remains a challenge in controlled release systems. We employed a photoresponsive molecule release system via light-triggered charge reversal nanoparticles to achieve a triggered, stepwise, and precise controlled release platform. This release system was based on photocleavage-bridged polysilsesquioxane nanoparticles which acted as nanocarriers of doxorubicin loaded on the surface via electrostatic interaction. The nanoparticles could reverse into positive charges triggered by 254 nm light irradiation due to the photocleavage of

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47

Liu, Weiyi, Sally Price, Grant Bennett, et al. "A landscape review of controlled release urea products: Patent objective, formulation and technology." Journal of Controlled Release 348 (August 2022): 612–30. http://dx.doi.org/10.1016/j.jconrel.2022.06.009.

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48

Qu, Peng, Shan Cheng Yan, Hua Lu, and Zu Hong Lu. "Flow-injection chemiluminescence determinations for human blood lead using controlled reagent release technology." Microchimica Acta 163, no. 3-4 (2008): 321–26. http://dx.doi.org/10.1007/s00604-008-0021-6.

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49

Seemann, H., C. Albayrak, and V. Rindler. "Development of controlled release formulations by means of ALRISE's ImSus ® platform technology." Journal of Controlled Release 148, no. 1 (2010): e16-e17. http://dx.doi.org/10.1016/j.jconrel.2010.07.009.

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50

OLUKMAN ŞAHİN, Merve, and Oya ŞANLI. "Controlled Release of 5-Fluorouracil from Biocompatible Polymeric Beads." Afyon Kocatepe University Journal of Sciences and Engineering 22, no. 2 (2022): 366–76. http://dx.doi.org/10.35414/akufemubid.1066566.

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5-Fluorouracil (5-FU), a pyrimidine analog, is a chemotherapy agent used in the treatment of a wide variety of cancers (breast, colorectal, gastrointestinal, etc.). However, its short plasma half-life, low selectivity against cancer cells and serious side effects limited its clinical use. In this study, it was aimed to minimize the negative properties of 5-FU with controlled release technology. For this purpose, 5-FU loaded poly(vinyl alcohol)/sodium alginate (PVA/NaAlg) beads were prepared by ionic crosslinking method using FeCl3 and beads were characterized by Fourier transform infrared spec

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