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Journal articles on the topic 'Conventional coagulation tests'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Curry, Andy NG, and JM Tom Pierce. "Conventional and near-patient tests of coagulation." Continuing Education in Anaesthesia Critical Care & Pain 7, no. 2 (2007): 45–50. http://dx.doi.org/10.1093/bjaceaccp/mkm002.

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Tur Martínez, Jaume, Patrizio Petrone, Alexander Axelrad, and Corrado P. Marini. "Comparison Between Thromboelastography and Conventional Coagulation Test: Should We Abandon Conventional Coagulation Tests in Polytrauma Patients?" Cirugía Española (English Edition) 96, no. 7 (2018): 443–49. http://dx.doi.org/10.1016/j.cireng.2018.07.012.

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3

Athota, Soumya, R. Srinivasan, M. Rajkumar, M. V. Bhargavi, and R. Suresh. "Thromboelastography vs. conventional coagulation tests in decompensated liver disease: a comparative analysis." Romanian Journal of Medical Practice 20, no. 2 (2025): 167–75. https://doi.org/10.37897/rjmp.2025.2.14.

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Introduction. Thromboelastography (TEG) is a dynamic assessment tool used to assess hemostasis with decompensated chronic liver disease (DCLD). Conventional coagulation tests, such as prothrombin time (PT), international normalized ratio (INR), and activated partial thromboplastin time (aPTT), may not fully reflect the complexity of coagulation abnormalities in these patients. This study investigates the correlation between TEG parameters, conventional coagulation tests, and platelet count in patients with and without clinical bleeding manifestations. Material and methods. A cross-sectional st

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Wang, Zhengwei, Jing Li, Qingwei Cao, Lei Wang, Fengzhi Shan, and Houyi Zhang. "Comparison Between Thromboelastography and Conventional Coagulation Tests in Surgical Patients With Localized Prostate Cancer." Clinical and Applied Thrombosis/Hemostasis 24, no. 5 (2017): 755–63. http://dx.doi.org/10.1177/1076029617724229.

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We aimed to examine hypercoagulable and hypocoagulable conditions in patients with prostate cancer using thromboelastography (TEG) and correlate TEG parameters with conventional coagulation test. The t test was used for comparing TEG parameters and routine coagulation results. Spearman rank-order correlation was used to describe the relationship of TEG and conventional tests. Sensitivity, specificity, positive predictive values, and negative predictive values were determined for bleeding and thrombosis. Totally, 20 patients had active bleeding postoperatively, 16 of whom showed hypocoagulation

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5

Lloyd-Donald, Patryck, Abhinav Vasudevan, Peter Angus, et al. "Comparison of Thromboelastography and Conventional Coagulation Tests in Patients With Severe Liver Disease." Clinical and Applied Thrombosis/Hemostasis 26 (January 1, 2020): 107602962092591. http://dx.doi.org/10.1177/1076029620925915.

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Objective: Thromboelastography (TEG) may provide rapid and clinically important coagulation information in acutely ill patients with chronic liver disease (CLD). Our objective was to describe the relationship between TEG and conventional coagulation tests (CCTs), which has not been previously explored in this population. Methods: In acutely ill patients with severe CLD (Child-Pugh score > 9, category C), we conducted a prospective observational study investigating coagulation assessment as measured by both CCTs and TEG. We used quantile regression to explore 30 associations between TEG para

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Subramanian, Arulselvi, Venencia Albert, Deepak Agrawal, Renu Saxena, and Ravindra Mohan Pandey. "Evaluation of the Utility of Thromboelastography in a Tertiary Trauma Care Centre." ISRN Hematology 2014 (February 12, 2014): 1–6. http://dx.doi.org/10.1155/2014/849626.

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Background. Thromboelastography (TEG) unlike conventional coagulation assays evaluates the dynamic interaction of clotting factors and platelets indicating an overall clot quality. Literature assessing the efficacy of TEG in identifying trauma associated bleeding is lacking. Aim. To compare TEG with conventional plasma based coagulation tests and assess whether TEG can serve as a screening test or replace the conventional routine test. Materials. Retrospective data was collected for 150 severe trauma patients. Patients with known evidence of severe comorbidities, which may influence the outcom

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Tsantes, Andreas G., Ilectra Loukopoulou, Dimitrios V. Papadopoulos, et al. "The Hypercoagulable Profile of Patients with Bone Tumors: A Pilot Observational Study Using Rotational Thromboelastometry." Cancers 14, no. 16 (2022): 3930. http://dx.doi.org/10.3390/cancers14163930.

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Introduction: A detailed evaluation of the malignancy-associated coagulopathy (MAC) in surgical patients with bone tumors may allow for more effective thromboprophylactic measures. The purpose of this study was to assess the perioperative hemostatic changes in patients with bone tumors, using rotational thromboelastometry (ROTEM). Methods: An observational study was performed, including 50 patients with bone tumors who underwent oncologic resection and 30 healthy controls, matched for age and gender. The preoperative and postoperative laboratory evaluation of coagulation in both groups include

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8

Yang, Jinzhu, and Lei Shen. "Clinical evaluation of hypercoagulability in advanced malignant tumors using thromboelastography and conventional coagulation tests." Medicine 104, no. 6 (2025): e41465. https://doi.org/10.1097/md.0000000000041465.

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This study compares the diagnostic value of conventional coagulation tests (CCTs) and thromboelastography (TEG) for high blood coagulation states in advanced malignant tumors and to explore the diagnostic efficacy of their combination. In this study, 120 patients with advanced malignancy were divided into hypercoagulable state (n = 62) and non-hypercoagulable state (n = 58) groups. Traditional coagulation tests or CCTs (including prothrombin time, activated partial thromboplastin time, international normalized ratio, fibrinogen, D-dimer, and platelet count) were conducted. Simultaneously, TEG

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9

Tripodi, A., L. A. Ramenghi, V. Chantarangkul, et al. "Normal thrombin generation in neonates in spite of prolonged conventional coagulation tests." Haematologica 93, no. 8 (2008): 1256–59. http://dx.doi.org/10.3324/haematol.12566.

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10

Massicotte, Luc, André Y. Denault, Lynda Thibeault, Zoltan Hevesi, Anna Nozza, and André Roy. "Relationship Between Conventional Coagulation Tests and Bleeding for 600 Consecutive Liver Transplantations." Transplantation 98, no. 2 (2014): e13-e15. http://dx.doi.org/10.1097/tp.0000000000000253.

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11

Holcomb, John B., Kristin M. Minei, Michelle L. Scerbo, et al. "Admission Rapid Thrombelastography Can Replace Conventional Coagulation Tests in the Emergency Department." Annals of Surgery 256, no. 3 (2012): 476–86. http://dx.doi.org/10.1097/sla.0b013e3182658180.

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12

Tripodi, Armando, Francesco Salerno, Veena Chantarangkul, et al. "Evidence of normal thrombin generation in cirrhosis despite abnormal conventional coagulation tests." Hepatology 41, no. 3 (2005): 553–58. http://dx.doi.org/10.1002/hep.20569.

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13

Wright, S., E. Wright, and W. Wright. "CORRELATION OF TEGPM AND CONVENTIONAL COAGULATION TESTS IN PATIENTS WITH INTRACRANIAL HEMORRHAGE." Chest 157, no. 6 (2020): A118. http://dx.doi.org/10.1016/j.chest.2020.05.132.

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Park, Sun Young. "Viscoelastic coagulation test for liver transplantation." Anesthesia and Pain Medicine 15, no. 2 (2020): 143–51. http://dx.doi.org/10.17085/apm.2020.15.2.143.

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Coagulation and transfusion management in patients undergoing liver transplantation is challenging. Proper perioperative monitoring of hemostasis is essential to predict the risk of bleeding during surgery, to detect potential causes of hemorrhage in time, and to guide hemostatic therapy. The value of conventional coagulation test is questionable in the acute perioperative setting due to their long turnaround time and the inability to adequately reflect the complex changes in hemostasis in patients with liver disease. Viscoelastic coagulation tests provide simultaneous measurement of multiple

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15

More, Shikhar, and Rakesh Garg. "Bleeding and Coagulopathy in Cancer – A Narrative Review." Journal of Onco-Anaesthesiology and Perioperative Medicine 2, no. 2 (2025): 51–61. https://doi.org/10.4103/joapm.joapm_1_25.

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Cancer and cancer therapy can interfere with coagulation physiology and lead to a myriad of clinical presentations, which need prompt but comprehensive evaluation and management. The clinical spectrum of coagulation abnormalities ranges from thrombotic complications such as venous thromboembolism and arterial micro-thrombi to haemorrhagic complications, including disseminated intravascular coagulation. The risk of developing venous thrombosis is highest in the first year following cancer diagnosis. Coagulation abnormalities are frequently encountered in the peri-operative period, as well as in

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16

Roitman, Eugene. "The inconsistencies between conventional and global lab tests in cardiosurgeric patient (a clinical case)." Clinical review for general practice 1, no. 1 (2020): 68–70. http://dx.doi.org/10.47407/kr2020.1.1.00010.

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The clinical case demonstrates inconsistencies between the results of thromboelastography and conventional coagulation lab tests at the early postoperative period of patient undergoing cardiosurgery. The analyzing of the revealed discrepancy proves that the opposition of laboratory methods as 'one against the other' for studying the hemostatic system is unacceptable.

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17

Veronese, LR, M. Miller, and WC Spearman. "Thromboelastography in mild, chronic liver disease: challenging conventional coagulation tests preceding liver biopsy." Southern African Journal of Anaesthesia and Analgesia 24, no. 5 (2018): 135–39. http://dx.doi.org/10.1080/22201181.2018.1510234.

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18

Lopachin, T., A. McGowan, S. Stuart, M. Gaspary, and E. Friedrich. "101 Thromboelastography versus Conventional Coagulation Tests in Pit Viper Envenomation and Antivenom Response." Annals of Emergency Medicine 76, no. 4 (2020): S40. http://dx.doi.org/10.1016/j.annemergmed.2020.09.112.

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19

Andreasen, Jo Bønding, Anne-Mette Hvas, Kirsten Christiansen, and Hanne Berg Ravn. "Can RoTEM®analysis be applied for haemostatic monitoring in paediatric congenital heart surgery?" Cardiology in the Young 21, no. 6 (2011): 684–91. http://dx.doi.org/10.1017/s1047951111000758.

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AbstractBackgroundSuccessful management of bleeding disorders after congenital heart surgery requires detection of specific coagulation disturbances. Whole-blood rotation thromboelastometry (RoTEM®) provides continuous qualitative haemostatic profiles, and the technique has shown promising results in adult cardiac surgery.SettingTo compare the performance of RoTEM®with that of conventional coagulation tests in children, we conducted a descriptive study in children undergoing congenital cardiac surgery. For that purpose, 60 children were enrolled and had blood samples taken before, immediately

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20

Gorki, Hagen, Julia Nakamura, Andreas Kunert, Markus Hoenicka, and Andreas Liebold. "Pericardial fluids or Cardiopulmonary Bypass—Is There a Major Culprit for Changes in Coagulation and Inflammation?" Thoracic and Cardiovascular Surgeon 68, no. 03 (2019): 219–22. http://dx.doi.org/10.1055/s-0039-1677836.

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Abstract Background From the results of a previous study, it remained to be investigated if a perioperative rise of few tested coagulation and inflammation markers is caused by conventional cardiopulmonary bypass (CPB) itself or rather by direct recirculation of pericardial fluids. Methods Forty-eight patients operated on with conventional CPB for myocardial revascularization were randomized either for direct recirculation of pericardial suction fluids or for cell saving (CS). Results Thrombin–antithrombin complexes showed lower values intraoperatively in the CS group (p < 0.0001), and D-di

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21

Akay, Olga Meltem. "The Double Hazard of Bleeding and Thrombosis in Hemostasis From a Clinical Point of View: A Global Assessment by Rotational Thromboelastometry (ROTEM)." Clinical and Applied Thrombosis/Hemostasis 24, no. 6 (2018): 850–58. http://dx.doi.org/10.1177/1076029618772336.

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Hemostasis is a complex dynamic process involving bleeding and thrombosis as two end-points. Conventional coagulation tests which are measured in plasma examine only isolated portions of the coagulation cascade, thereby giving no information on important interactions essential to the clinical evaluation of hemostatic function. Thromboelastography (TEG), originally described in 1948 has improved over the decades and become a valuable tool of coagulation testing because of the limitations of standard coagulation tests. TEG is a technique that provides data about the entire coagulation system, fr

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22

Vollmer, Nicholas J., Nicole A. Leshko, Charles S. Wilson, and Brian W. Gilbert. "A Review of Thromboelastography for Nurses." Critical Care Nurse 43, no. 3 (2023): 29–37. http://dx.doi.org/10.4037/ccn2023371.

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Background Thromboelastography is a viscoelastic test with multiple potential advantages over conventional coagulation tests in various disease states. Thromboelastography rapidly provides qualitative and quantitative information related to a patient’s coagulation status. Objective To describe recent studies of the use of thromboelastography in various clinical states and how thromboelastography is used in coagulation management. Methods A literature review using the MEDLINE and PubMed databases was conducted. The updated methodology for integrated reviews by Whittemore and Knafl was followed.

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23

Ambulkar, Reshma, Vignesh Baskar, Shraddha Patkar, et al. "Evaluation of perioperative routine coagulation testing versus thromboelastography for major liver resection – A single-arm, prospective, interventional trial (PORTAL trial)." Indian Journal of Anaesthesia 67, no. 12 (2023): 1077–83. http://dx.doi.org/10.4103/ija.ija_344_23.

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Background and Aims: The International Normalised Ratio (INR), which assesses the loss of procoagulant factors in the extrinsic pathway, fails to evaluate the coagulation abnormalities comprehensively after a major liver resection, which often leads to reduced synthesis of procoagulant and anticoagulant-factors. This study was conducted with an aim to study the trend and compare the results of routine coagulation tests and thromboelastography (TEG) during the perioperative period in patients undergoing major liver resections (≥3 segments). Methods: Twenty-five patients who underwent a major li

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24

Corrêa, Thiago Domingos, Ricardo Luiz Cordioli, João Carlos Campos Guerra, et al. "Coagulation profile of COVID-19 patients admitted to the ICU: An exploratory study." PLOS ONE 15, no. 12 (2020): e0243604. http://dx.doi.org/10.1371/journal.pone.0243604.

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Background Coagulation abnormalities in COVID-19 patients have not been addressed in depth. Objective To perform a longitudinal evaluation of coagulation profile of patients admitted to the ICU with COVID-19. Methods Conventional coagulation tests, rotational thromboelastometry (ROTEM), platelet function, fibrinolysis, antithrombin, protein C and S were measured at days 0, 1, 3, 7 and 14. Based on median total maximum SOFA score, patients were divided in two groups: SOFA ≤ 10 and SOFA > 10. Results Thirty patients were studied. Some conventional coagulation tests, as aPTT, PT and INR remain

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Lopez Kerlegand, J., K. Navar Gallegos, L. Medina Concebida, and J. Hernandez Tiscareno. "P0329 / #717: COMPARISON OF TRANSFUSIONAL PRACTICE WITH VISCOELASTIC TESTS VERSUS CONVENTIONAL COAGULATION TESTS IN CONGENITAL HEART SURGERY PATIENT." Pediatric Critical Care Medicine 22, Supplement 1 3S (2021): 177. http://dx.doi.org/10.1097/01.pcc.0000739656.56126.56.

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26

Ågren, Anna, Agneta Taune Wikman, Margareta Holmström, Anders Östlund, and Gustaf Edgren. "Thromboelastography (TEG®) compared to conventional coagulation tests in surgical patients – a laboratory evaluation." Scandinavian Journal of Clinical and Laboratory Investigation 73, no. 3 (2013): 214–20. http://dx.doi.org/10.3109/00365513.2013.765960.

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Yoon, Ji‐Uk, Ji‐Hyun Cheon, Yoon Ji Choi, et al. "The correlation between conventional coagulation tests and thromboelastography in each phase of liver transplantation." Clinical Transplantation 33, no. 3 (2019): e13478. http://dx.doi.org/10.1111/ctr.13478.

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28

Janko, Natasha, Ammar Majeed, William Kemp, and Stuart K. Roberts. "Viscoelastic Tests as Point-of-Care Tests in the Assessment and Management of Bleeding and Thrombosis in Liver Disease." Seminars in Thrombosis and Hemostasis 46, no. 06 (2020): 704–15. http://dx.doi.org/10.1055/s-0040-1715475.

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AbstractViscoelastic point-of-care (VET POC) tests provide a global assessment of hemostasis and have an increasing role in the management of bleeding and blood component delivery across several clinical settings. VET POC tests have a rapid turnaround time, provide a better overall picture of hemostasis, predict bleeding more accurately than conventional coagulation tests, and reduce blood component usage and health care costs. Despite commonly having abnormal conventional coagulation tests, most patients with chronic liver disease have a “rebalanced” hemostasis. However, this hemostatic balan

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Padilla-Arellanes, S., F. Constantino-Casas, L. Núnez-Ochoa, J. Doubek, C. Vega-Murguia, and J. Bouda. "Coagulation Tests and Selected Biochemical Analytes in Dairy Cows with Hepatic Lipidosis." Acta Veterinaria Brno 76, no. 4 (2007): 541–46. http://dx.doi.org/10.2754/avb200776040541.

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The aim of this study was to determine the values and changes in conventional and optimised clotting tests, as well as in selected biochemical analytes during hepatic lipidosis in postpartum dairy cows. Ten healthy and ten Holstein cows with hepatic lipidosis were selected based upon clinical history, clinical examination, liver biopsy, flotation test and histological analysis of hepatic tissue. Prothrombin time (PT) and partial thromboplastin time (PTT) were determined in non-diluted and diluted blood plasma samples. Clotting times determined in diluted plasma samples were prolonged in cows w

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Gaspari, Rita, Paola Aceto, Simone Carelli, et al. "Discrepancy Between Conventional Coagulation Tests and Thromboelastography During the Early Postoperative Phase of Liver Resection in Neoplastic Patients: A Prospective Study Using the New-Generation TEG®6s." Journal of Clinical Medicine 14, no. 9 (2025): 2866. https://doi.org/10.3390/jcm14092866.

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Background: Thromboelastography-6s (TEG®6s), a novel device developed to assess coagulation status, presents advantages such as less frequent calibration, ease of use, and greater stability against movements compared to the previous system (TEG5000). This is the first study in the literature to compare coagulation profiles in the early postoperative period of liver resection (LR) using conventional coagulation tests (CCTs) and TEG®6s. Methods: Forty-six adult patients admitted to the ICU post-surgery after elective LR for malignancy were included. CCTs were used to classify patients into hypoc

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Abeysundara, Lasitha, Susan Mallett, and Ben Clevenger. "Point-of-Care Testing in Liver Disease and Liver Surgery." Seminars in Thrombosis and Hemostasis 43, no. 04 (2017): 407–15. http://dx.doi.org/10.1055/s-0037-1599154.

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AbstractThe alterations in coagulation and hemostasis that accompany liver disease are complex, and while patients with this disease have traditionally been perceived as having a bleeding diathesis, it is now understood that in stable patients hemostasis is “re-balanced.” Hepatic surgery, and particularly liver transplantation, can be associated with large fluid shifts, massive bleeding, and coagulopathy, as well as postoperative thrombosis. Point-of-care tests (POCTs) of coagulation facilitate goal-directed treatments and hemostatic monitoring in dynamic environments where the coagulation sta

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Jin, Wang-yi, Yong Pang, Xing-chen Zhang, et al. "Gender Differences do not Influence the Blood Coagulopathy in Patients Undergoing Total Knee Arthroplasty: A Retrospective Thromboelastography Analysis." Clinical and Applied Thrombosis/Hemostasis 27 (January 2021): 107602962110557. http://dx.doi.org/10.1177/10760296211055716.

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Objective Deep vein thrombosis (DVT) is one of the severe complications after total knee arthroplasty (TKA). Gender has been considered to influence the incidence of the thrombosis formation in TKA patients. However, it remains controversial which gender would be more prone to form thrombosis. The aim of this study was to assess the effects of gender differences on coagulation status after TKA via the thromboelastography (TEG). Methods A total of 57 male patients who underwent primary TKA from September 2015 to January 2021 were included in this study. According to the matching principle of ag

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Acuña, Paula, Elena Monzón Manzano, Elena G Arias-Salgado, et al. "Laboratory Characterization of Unclassified Bleeding Disorders By Non-Conventional Tests." Blood 138, Supplement 1 (2021): 4235. http://dx.doi.org/10.1182/blood-2021-151203.

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Abstract Introduction: Hematologists frequently face a percentage of patients with a mild bleeding tendency due to a haemostatic abnormality that cannot be identified with conventional laboratory techniques. Such patients are termed as having an unclassified bleeding disorder (UBD). A good diagnosis is important in order to prevent bleedings during invasive processes and/or childbirth by choosing the optimal therapeutic treatment. We aimed to investigate hemostatic parameters that may be altered in patients with UBD in order to determine the cause of their bleeding symptoms. In particular, pos

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Yue, Liang, Yasuhiro Nakagawa, and Mitsuhiro Ebara. "Design of Apoptotic Cell-Inspired Particles as a Blood Coagulation Test." Biomimetics 9, no. 6 (2024): 367. http://dx.doi.org/10.3390/biomimetics9060367.

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The blood coagulation test is an indispensable test for monitoring the blood coagulation and fibrinolysis functions. Currently, activated partial thromboplastin time (APTT) is the most widely used approach to coagulation testing. However, APTT reagents need to be optimized due to the fact that they are unstable, highly variable, and cannot be easily controlled. In this study, we created apoptotic cell-inspired methacryloyloxyethyl phosphorylserine (MPS) particles for blood coagulation as an alternative to conventional APTT reagents. Particle size could be controlled by changing the concentrati

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Guerrero, M., A. García, M. García, R. Elices, and F. Martínez. "Correlation of early rotation thromboelastography parameters with conventional coagulation tests in patients undergoing liver transplantation." European Journal of Anaesthesiology 27 (June 2010): 107. http://dx.doi.org/10.1097/00003643-201006121-00343.

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Hess, John R., Allison L. Lindell, Lynn G. Stansbury, Richard P. Dutton, and Thomas M. Scalea. "The prevalence of abnormal results of conventional coagulation tests on admission to a trauma center." Transfusion 49, no. 1 (2009): 34–39. http://dx.doi.org/10.1111/j.1537-2995.2008.01944.x.

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Fortner, Grady A., John J. Devlin, Andrew J. McGowan, Michael Boboc, Ramesh Natarajan, and Gregory J. Zarow. "Comparison of thromboelastography versus conventional coagulation tests in simulated Crotalus atrox envenomation using human blood." Toxicon 175 (February 2020): 19–27. http://dx.doi.org/10.1016/j.toxicon.2019.12.001.

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Lisman, Ton, Kamran Bakhtiari, Ilona T. A. Pereboom, Herman G. D. Hendriks, Joost C. M. Meijers, and Robert J. Porte. "Normal to increased thrombin generation in patients undergoing liver transplantation despite prolonged conventional coagulation tests." Journal of Hepatology 52, no. 3 (2010): 355–61. http://dx.doi.org/10.1016/j.jhep.2009.12.001.

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Smart, Laura, Khalid Mumtaz, Danielle Scharpf, et al. "Rotational Thromboelastometry or Conventional Coagulation Tests in Liver Transplantation: Comparing Blood Loss, Transfusions, and Cost." Annals of Hepatology 16, no. 6 (2017): 916–23. http://dx.doi.org/10.5604/01.3001.0010.5283.

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Konstantinidi, Aikaterini, Rozeta Sokou, Stavroula Parastatidou, et al. "Clinical Application of Thromboelastography/Thromboelastometry (TEG/TEM) in the Neonatal Population: A Narrative Review." Seminars in Thrombosis and Hemostasis 45, no. 05 (2019): 449–57. http://dx.doi.org/10.1055/s-0039-1692210.

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AbstractHemostasis is a dynamic age-related process, which gradually evolves from fetal life throughout childhood until adulthood. Although at birth there is a hemostatic deficit of most coagulation factors, studies have shown that this “hemostatic immaturity” is functionally counterbalanced in healthy term or preterm newborns. This delicate hemostatic balance is, however, deranged in sick neonates, resulting in an enhanced risk of hemorrhage and/or thrombosis. In critically ill neonates, conventional coagulation tests do not seem to provide reliable information or indications regarding the fu

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Barrett, Liam, Anne Manktelow, William Thomas, et al. "1790 Longitudinal coagulation profiles in patients presenting with acute severe traumatic brain injury (TBI): A prospective observational study." Emergency Medicine Journal 39, no. 12 (2022): A982.2—A983. http://dx.doi.org/10.1136/emermed-2022-rcem2.36.

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Aims, Objectives and BackgroundPatients who have sustained a traumatic brain injury (TBI) can have disturbances in coagulation that are distinct from other traumatic bleeding states.1 Coagulopathy is a risk factor for exacerbation of the primary injury, and these patients have less favourable outcomes and increased mortality compared to non-coagulopathic patients.1 Little is known about the longitudinal coagulation changes following TBI.The aim of this pilot study was to investigate the coagulation profiles of patients presenting with severe TBI over the first 7 days following injury.Method an

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Frantzeskaki, Frantzeska, Dimitrios Konstantonis, Michail Rizos, et al. "Extracorporeal Membrane Oxygenation (ECMO)-Associated Coagulopathy in Adults." Diagnostics 13, no. 23 (2023): 3496. http://dx.doi.org/10.3390/diagnostics13233496.

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Extracorporeal membrane oxygenation (ECMO) is used for the management of severe respiratory and cardiac failure and as a bridge to achieve definite treatment or transplantation. ECMO-associated coagulopathy (EAC) is a frequent complication leading to high rates of thrombosis or severe haemorrhage, contributing to morbidity and mortality among patients. Understanding the pathophysiology of EAC is substantial for effectively managing patients on ECMO. We analyse the underlying mechanism of EAC and discuss the monitoring of the coagulation profile, combining the viscoelastic point-of-care assays

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Bunch, Connor M., Anthony V. Thomas, John E. Stillson, et al. "Preventing Thrombohemorrhagic Complications of Heparinized COVID-19 Patients Using Adjunctive Thromboelastography: A Retrospective Study." Journal of Clinical Medicine 10, no. 14 (2021): 3097. http://dx.doi.org/10.3390/jcm10143097.

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Background: The treatment of COVID-19 patients with heparin is not always effective in preventing thrombotic complications, but can also be associated with bleeding complications, suggesting a balanced approach to anticoagulation is needed. A prior pilot study supported that thromboelastography and conventional coagulation tests could predict hemorrhage in COVID-19 in patients treated with unfractionated heparin or enoxaparin, but did not evaluate the risk of thrombosis. Methods: This single-center, retrospective study included 79 severely ill COVID-19 patients anticoagulated with intermediate

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Korpallová, Barbora, Matej Samoš, Tomáš Bolek, et al. "Role of Thromboelastography and Rotational Thromboelastometry in the Management of Cardiovascular Diseases." Clinical and Applied Thrombosis/Hemostasis 24, no. 8 (2018): 1199–207. http://dx.doi.org/10.1177/1076029618790092.

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The monitoring of coagulation by viscoelastometric methods—thromboelastography and rotational thromboelastometry—may detect the contributions of cellular and plasma components of hemostasis. These methods might overcome some of the serious limitations of conventional laboratory tests. Viscoelastic testing can be repeatedly performed during and after surgery and thus provides a dynamic picture of the coagulation process during these periods. Several experiences with the use of these methods in cardiovascular surgery have been reported, but there is perspective for more frequent use of these ass

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Kujovich, Jody L. "Coagulopathy in liver disease: a balancing act." Hematology 2015, no. 1 (2015): 243–49. http://dx.doi.org/10.1182/asheducation-2015.1.243.

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Abstract Liver disease results in complex alterations of all 3 phases of hemostasis. It is now recognized that hemostasis is rebalanced in chronic liver disease. The fall in clotting factor levels is accompanied by a parallel fall in anticoagulant proteins. High von Willebrand factor levels counteract defects in primary hemostasis. Conventional coagulation tests do not fully reflect the derangement in hemostasis and do not accurately predict the risk of bleeding. Global coagulation assays (thrombin generation, thromboelastography) reflect the interaction between procoagulant factors, anticoagu

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Premkumar, Madhumita, Sekar Loganathan, Kamal Kajal, et al. "COVID-19-related dynamic coagulation disturbances and anticoagulation strategies using conventional D-dimer and point-of-care Sonoclot tests: a prospective cohort study." BMJ Open 12, no. 5 (2022): e051971. http://dx.doi.org/10.1136/bmjopen-2021-051971.

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Objectives Coagulation changes associated with COVID-19 suggest the presence of a hypercoagulable state with pulmonary microthrombosis and thromboembolic complications. We assessed the dynamic association of COVID-19-related coagulation abnormalities with respiratory failure and mortality. Design Single-centre, prospective cohort study with descriptive analysis and logistic regression. Setting Tertiary care hospital, North India. Participants Patients with COVID-19 pneumonia requiring intensive care unit (ICU) admission between August 2020 and November 2020. Primary and secondary outcome measu

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Hasegawa, T., K. Hashimoto, T. Onitsuka, K. Goto, and N. Tambo. "Characteristics of Metal-Polysilicate Coagulants." Water Science and Technology 23, no. 7-9 (1991): 1713–22. http://dx.doi.org/10.2166/wst.1991.0626.

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The authors propose metal-polysilicate complexes as new inorganic polymer coagulants for the removal of colloidal suspensions. In the first part of this paper, procedures of silicic acid polymerization to attain very higher molecular weight polysilicates in a much more stable state than conventional methods are discussed. Then, a procedure for introducing metal ions such as aluminum and iron into the polymerized silicic acid is presented to give coagulation capability, i.e. charge-neutralizing capacity, to the polysilicic acid. Several new inorganic polymers are thus prepared as cationic coagu

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Tang, Ning, Xi Jin, Ziyong Sun, and Cui Jian. "Effects of hemolysis and lipemia interference on kaolin-activated thromboelastography, and comparison with conventional coagulation tests." Scandinavian Journal of Clinical and Laboratory Investigation 77, no. 2 (2017): 98–103. http://dx.doi.org/10.1080/00365513.2016.1271906.

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Shin, Gwy-Am, and Mark D. Sobsey. "Removal of norovirus from water by coagulation, flocculation and sedimentation processes." Water Supply 15, no. 1 (2014): 158–63. http://dx.doi.org/10.2166/ws.2014.100.

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In this study, we determined the removal of a prototype human norovirus (Norwalk virus, NV) by bench-scale alum coagulation, flocculation and sedimentation processes using reverse transcriptase polymerase chain reaction (RT-PCR) for norovirus assays. After determining optimum conditions for the coagulation, flocculation and sedimentation processes in terms of turbidity reduction, jar tests were performed using the same waters seeded with test viruses. For comparison, two other important health-related viruses, poliovirus 1 (PV1) and coliphage MS2, were included in this study. The removal of NV

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Caspers, Michael, Johannes Fabian Holle, Ulrich Limper, Matthias Fröhlich, and Bertil Bouillon. "Global Coagulation Testing in Acute Care Medicine: Back to Bedside?" Hämostaseologie 42, no. 06 (2022): 400–408. http://dx.doi.org/10.1055/a-1938-1984.

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Abstract Objectives Detailed and decisive information about the patients' coagulation status is important in various emergency situations. Conventional global coagulation testing strategies are often used to provide a quick overview, but several limitations particularly in the trauma setting are well described. With the introduction of direct oral anticoagulations (DOACs), a milestone for several disease entities resulting in overall improved outcomes could be reached, but at the same time providing new diagnostic challenges for the emergency situation. Design As an alternative to conventional

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