Academic literature on the topic 'Conventional dendritic cells'

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Journal articles on the topic "Conventional dendritic cells"

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Audiger, Cindy, and Sylvie Lesage. "Merocytic dendritic cell: a new subset of conventional dendritic cells." Journal of Immunology 202, no. 1_Supplement (2019): 118.11. http://dx.doi.org/10.4049/jimmunol.202.supp.118.11.

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Abstract Conventional dendritic cells (cDC) are potent antigen-presenting cells that induce the activation of naïve T cells in response to pathogens. cDC activity is mediated primarily by two cDC subsets, namely cDC1 and cDC2, each bearing unique properties. Recently, another DC subset, termed merocytic dendritic cells (mcDC), was defined. In contrast to both cDC1 and cDC2, mcDC are able to reverse T cell anergy, even in non-inflammatory conditions, properties that could be exploited to potentiate cancer treatments. Here, we further characterize mcDC to determine their relationship to cDCs. Fi
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Segura, Elodie, June Wong, and José A. Villadangos. "Cutting Edge: B220+CCR9− Dendritic Cells Are Not Plasmacytoid Dendritic Cells but Are Precursors of Conventional Dendritic Cells." Journal of Immunology 183, no. 3 (2009): 1514–17. http://dx.doi.org/10.4049/jimmunol.0901524.

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Chow, Kevin V., Andrew M. Lew, Robyn M. Sutherland, and Yifan Zhan. "Monocyte-Derived Dendritic Cells Promote Th Polarization, whereas Conventional Dendritic Cells Promote Th Proliferation." Journal of Immunology 196, no. 2 (2015): 624–36. http://dx.doi.org/10.4049/jimmunol.1501202.

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Smrekar, Natasa, David Drobne, Lojze M. Smid, et al. "Dendritic cell profiles in the inflamed colonic mucosa predict the responses to tumor necrosis factor alpha inhibitors in inflammatory bowel disease." Radiology and Oncology 52, no. 4 (2018): 443–52. http://dx.doi.org/10.2478/raon-2018-0045.

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Abstract Background Dendritic cells play crucial roles in the control of inflammation and immune tolerance in the gut. We aimed to investigate the effects of tumor necrosis factor alpha (TNFa) inhibitors on intestinal dendritic cells in patients with inflammatory bowel disease and the potential role of intestinal dendritic cells in predicting the response to treatment. Patients and methods Intestinal biopsies were obtained from 30 patients with inflammatory bowel disease before and after treatment with TNFa inhibitors. The proportions of lamina propria dendritic cell phenotypes were analysed u
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Cabeza-Cabrerizo, Mar, Ana Cardoso, Carlos M. Minutti, Mariana Pereira da Costa, and Caetano Reis e Sousa. "Dendritic Cells Revisited." Annual Review of Immunology 39, no. 1 (2021): 131–66. http://dx.doi.org/10.1146/annurev-immunol-061020-053707.

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Dendritic cells (DCs) possess the ability to integrate information about their environment and communicate it to other leukocytes, shaping adaptive and innate immunity. Over the years, a variety of cell types have been called DCs on the basis of phenotypic and functional attributes. Here, we refocus attention on conventional DCs (cDCs), a discrete cell lineage by ontogenetic and gene expression criteria that best corresponds to the cells originally described in the 1970s. We summarize current knowledge of mouse and human cDC subsets and describe their hematopoietic development and their phenot
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Diao, Jun, Anastassia Mikhailova, Michael Tang, Hongtao Gu, Jun Zhao, and Mark S. Cattral. "Immunostimulatory conventional dendritic cells evolve into regulatory macrophage-like cells." Blood 119, no. 21 (2012): 4919–27. http://dx.doi.org/10.1182/blood-2011-11-392894.

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Abstract Dendritic cell (DC) homeostasis in peripheral tissues reflect a balance between DC generation, migration, and death. The current model of DC ontogeny indicates that pre-cDCs are committed to become terminal conventional DCs (cDCs). Here, we report the unexpected finding that proliferating immunostimulatory CD11c+ MHC class II+ cDCs derived from pre-cDCs can lose their DC identity and generate progeny that exhibit morphologic, phenotypic, and functional characteristics of regulatory macrophages. DC-derived–macrophages (DC-d-Ms) potently suppress T-cell responses through the production
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Velte, T. J., and R. F. Miller. "Spiking and nonspiking models of starburst amacrine cells in the rabbit retina." Visual Neuroscience 14, no. 6 (1997): 1073–88. http://dx.doi.org/10.1017/s0952523800011780.

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AbstractThe integrative properties of starburst amacrine cells in the rabbit retina were studied with compartmental models and computer-simulation techniques. The anatomical basis for these simulations was provided by computer reconstructions of intracellularly stained starburst amacrine cells and published data on dendritic diameter and biophysical properties. Passive and active membrane properties were included to simulate spiking and nonspiking behavior. Simulated synaptic inputs into one or more compartments consisted of a bipolar-like conductance change with peak and steady-state componen
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Lee, Jun Seong, Se-Jin Jeong, Sinai Kim, et al. "Conventional Dendritic Cells Impair Recovery after Myocardial Infarction." Journal of Immunology 201, no. 6 (2018): 1784–98. http://dx.doi.org/10.4049/jimmunol.1800322.

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Weslow-Schmidt, Janet L., Nancy A. Jewell, Sara E. Mertz, J. Pedro Simas, Joan E. Durbin, and Emilio Flaño. "Type I Interferon Inhibition and Dendritic Cell Activation during Gammaherpesvirus Respiratory Infection." Journal of Virology 81, no. 18 (2007): 9778–89. http://dx.doi.org/10.1128/jvi.00360-07.

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ABSTRACT The respiratory tract is a major mucosal site for microorganism entry into the body, and type I interferon (IFN) and dendritic cells constitute a first line of defense against viral infections. We have analyzed the interaction between a model DNA virus, plasmacytoid dendritic cells, and type I IFN during lung infection of mice. Our data show that murine gammaherpesvirus 68 (γHV68) inhibits type I IFN secretion by dendritic cells and that plasmacytoid dendritic cells are necessary for conventional dendritic cell maturation in response to γHV68. Following γHV68 intranasal inoculation, t
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Edelson, Brian T., Wumesh KC, Richard Juang та ін. "Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells". Journal of Experimental Medicine 207, № 4 (2010): 823–36. http://dx.doi.org/10.1084/jem.20091627.

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Although CD103-expressing dendritic cells (DCs) are widely present in nonlymphoid tissues, the transcription factors controlling their development and their relationship to other DC subsets remain unclear. Mice lacking the transcription factor Batf3 have a defect in the development of CD8α+ conventional DCs (cDCs) within lymphoid tissues. We demonstrate that Batf3−/− mice also lack CD103+CD11b− DCs in the lung, intestine, mesenteric lymph nodes (MLNs), dermis, and skin-draining lymph nodes. Notably, Batf3−/− mice displayed reduced priming of CD8 T cells after pulmonary Sendai virus infection,
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Dissertations / Theses on the topic "Conventional dendritic cells"

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Chen, Titi. "Type 1 conventional dendritic cells in kidney disease." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/27814.

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Dendritic cells (DCs) are central orchestrators of the immune system, which regulate both innate and adaptive immune responses. They can be broadly categorized into plasmacytoid DCs (pDCs) and conventional DCs (cDCs). cDC1s are a major subset of conventional DCs and play an important role in kidney disease. In this study, I firstly examined cDC1s in human kidney disease through analysing frozen human kidney biopsy samples. Secondly, I investigated the mechanisms of effects of cDC1s in experimental kidney disease, namely Adriamycin nephropathy and anti-GBM disease. Lastly, I explored the therap
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Papaioannou, Nikolaos [Verfasser], and Barbara [Akademischer Betreuer] Schraml-Schotta. "Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice / Nikolaos Papaioannou ; Betreuer: Barbara Schraml-Schotta." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2021. http://d-nb.info/1239557248/34.

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Schönheit, Jörg. "A phagocyte-specific Irf8 gene enhancer establishes early conventional dendritic cell commitment." Phd thesis, Universität Potsdam, 2011. http://opus.kobv.de/ubp/volltexte/2011/5548/.

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Haematopoietic development is a complex process that is strictly hierarchically organized. Here, the phagocyte lineages are a very heterogeneous cell compartment with specialized functions in innate immunity and induction of adaptive immune responses. Their generation from a common precursor must be tightly controlled. Interference within lineage formation programs for example by mutation or change in expression levels of transcription factors (TF) is causative to leukaemia. However, the molecular mechanisms driving specification into distinct phagocytes remain poorly understood. In the presen
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Schönheit, Jörg [Verfasser], and Bernd [Akademischer Betreuer] Müller-Röber. "A phagocyte-specific Irf8 gene enhancer establishes early conventional dendritic cell commitment / Jörg Schönheit. Betreuer: Bernd Müller-Röber." Potsdam : Universitätsbibliothek der Universität Potsdam, 2011. http://d-nb.info/1018122036/34.

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Oliveira, Luís Filipe Henriques. "Understanding the Genetic Program of Conventional Dendritic Cells Type 2 with Direct Cell Reprogramming." Master's thesis, 2019. http://hdl.handle.net/10316/87846.

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Dissertação de Mestrado em Biologia Celular e Molecular apresentada à Faculdade de Ciências e Tecnologia<br>As células dendríticas (DCs) constituem uma linhagem de células sanguíneas notavelmente heterogénea e são responsáveis por interligar as repostas imunitárias inata e adquirida. As células dendríticas convencionais (cDCs) funcionam como células apresentadoras de antigénios (APCs) profissionais ao apresentarem os antigénios por elas captados a linfócitos T imaturos podendo ser divididas em dois grandes subgrupos: cDCs tipo 1 e tipo 2. Enquanto as cDC1 realizam principalmente apresentação
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Mendes, Cátia da Silva. "Analysis of monocyte-derived dendritic cells obtained through conventional vs. fast differentiation/maturation protocols." Master's thesis, 2019. http://hdl.handle.net/10773/29894.

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Dendritic cells (DCs) are cells specialized in antigen presentation that play an important role in the connection between innate and adaptive immunity. These cells have the unique ability to recognize, capture, process and present antigens to naïve T cells, leading to their polarization in different effector populations. Because of this ability, DCs have been used in recent decades to develop cancer immunotherapy approaches. In this type of cellular immunotherapy, the production of ex vivo DCs is necessary, and there are several protocols for this purpose. The aim of the present work was to co
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Baker, Margaret. "Generation of conventional dendritic cells from induced pluripotent stem cells for the study of the role of interferon regulatory factor 5 in systemic lupus erythematosus." Thesis, 2019. https://hdl.handle.net/2144/38586.

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Systemic lupus erythematosus (SLE) develops when genetically susceptible individuals lose tolerance to autoantigens, likely as a result of an environmental insult. The list of identified genetic susceptibilities is expansive, however variants in the interferon regulatory factor 5 (IRF5) gene have consistently and convincingly been shown to be associated with an increased risk of developing SLE across all ethnic and racial groups examined. These genetic variants are hypothesized to produce a gain-of-function phenotype due to increased IRF5 mRNA and increased stability of the IRF5 protein; how
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Lee, Junseong. "Critical roles of dendritic cells and macrophages in cardiovascular disease." Thèse, 2019. http://hdl.handle.net/1866/23532.

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Cardiovascular disease is a major cause of mortality in the world, and is rapidly increasing. To understand the inflammatory response of various diseases, we have made tremendous advances in molecular and cellular research to show clear evidence that macrophages and dendritic cells play central roles in cardiovascular diseases, such as atherosclerosis and myocardial infarction. We have identified the two conventional DCs subsets (cDC1 and cDC2) in heart of healthy mouse. As expected, we found that the IRF8-expressing cDC1, but not the IRF4-expressing cDC2, was dependent on Flt3 for its devel
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Audiger, Cindy. "Les cellules dendritiques mérocytiques : un nouveau sous-type de cellules dendritiques conventionnelles spécifiquement régulée par Bim." Thèse, 2019. http://hdl.handle.net/1866/23527.

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À l’inverse des autres sous types de cellules dendritiques conventionnelles (cDC), la présentation de peptides dérivés de corps apoptotiques par les DC mérocytiques (mcDC) cause un bris de la tolérance. Ces cellules induisent le diabète lorsqu’elles présentent des peptides dérivés de cellules bêta du pancréas. De plus, chargées avec des peptides dérivés de cellules tumorales, elles permettent la réactivation des lymphocytes T et l’élimination de la tumeur. Ces propriétés spécifiques aux mcDCs mettent en évidence de nouveaux aspects dans le contrôle des bris de tolérance.
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Book chapters on the topic "Conventional dendritic cells"

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van de Laar, Lianne, Martin Guilliams, and Simon Tavernier. "Isolation of Conventional Dendritic Cells from Mouse Lungs." In Methods in Molecular Biology. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3606-9_10.

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Luo, Xinlong, Sreekumar Balan, Catharina Arnold-Schrauf, and Marc Dalod. "In Vitro Generation of Human Cross-Presenting Type 1 Conventional Dendritic Cells (cDC1s) and Plasmacytoid Dendritic Cells (pDCs)." In Methods in Molecular Biology. Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-2938-3_10.

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O’Keeffe, Meredith, Ben Fancke, and Hubertus Hochrein. "The Generation of Plasmacytoid and Conventional Dendritic Cells with M-CSF." In Methods in Molecular Biology. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60761-421-0_12.

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Schotte, Remko, Heike Schmidlin, Maho Nagasawa, et al. "Isolation and In Vitro Generation of Gene-Manipulated Human Plasmacytoid and Conventional Dendritic Cells." In Methods in Molecular Biology. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60761-421-0_5.

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De Leeuw, Elisabeth, Cédric Bosteels, Bart N. Lambrecht, and Hamida Hammad. "Isolation of Conventional Murine Lung Dendritic Cell Subsets." In Methods in Molecular Biology. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2364-0_17.

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Scott, Charlotte L., Pamela B. Wright, Simon W. F. Milling, and Allan McI Mowat. "Isolation and Identification of Conventional Dendritic Cell Subsets from the Intestine of Mice and Men." In Methods in Molecular Biology. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3606-9_7.

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Scott, Charlotte L., and Bart N. Lambrecht. "Conventional Dendritic Cells: Identification, Subsets, Development, and Functions." In Encyclopedia of Immunobiology. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-12-374279-7.08015-2.

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Pakalniškytė, Dalia, and Barbara U. Schraml. "Tissue-Specific Diversity and Functions of Conventional Dendritic Cells." In Advances in Immunology. Elsevier, 2017. http://dx.doi.org/10.1016/bs.ai.2017.01.003.

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Rej, Arundhati, Ms Razia, Anukriti Mehra, Ayushi Maurya, and Deepika delsa dean. "CURRENT UPDATES ON IMMUNOTHERAPY AND THE SCOPE OF NANOMEDICINE IN CANCER THERAPY." In Futuristic Trends in Biotechnology Volume 3 Book 21. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bkbt21p1ch14.

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A brief history Cancer immunotherapy has brought significant improvements in survival and quality of life. It has established itself as a pillar of cancer care. We emphasize how advancements in cancer immunotherapy have been made possible by its history. The current drawbacks and restrictions of checkpoint immunotherapy are also highlighted. The formation of tumors has been demonstrated to be significantly influenced by immune infiltrates in the tumor microenvironment. The processes of cancer-immune evasion might be better understood with more research and discussion against immune cells that
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Abe, Hiroyuki, Touko Shimamoto, Shinichiro Akiyama, and Minako Abe. "Targeted Cancer Therapy by Dendritic Cell Vaccine." In Cancer Treatment - Conventional and Innovative Approaches. InTech, 2013. http://dx.doi.org/10.5772/55450.

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Conference papers on the topic "Conventional dendritic cells"

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Cedeno- Vente, M. L., I. Karaman, A. C. Ferrel- Alvarez, R. Case, M. Vaughan, and H. Castaneda. "Integration of Microstructure- Mechanical with Corrosion Characterization of UNS S31603 Material Manufactured by Direct Energy Deposition." In CONFERENCE 2023. AMPP, 2023. https://doi.org/10.5006/c2023-19427.

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Abstract The present work studies the effect of microstructure on corrosion and mechanical characteristics of a UNS S31603 stainless steel manufactured by conventional and Direct Energy Deposition (DED) methods. The microstructure of DED samples was composed of three regions: columnar dendritic, cellular, and mixed dendritic/cellular. The resulting microstructure showed that some regions were enriched with Mo and Cr and depleted of Fe at the sub-grain boundaries. The elemental micro-segregation acts as a micro-galvanic cell influencing the pitting corrosion. The corrosion resulted in more loca
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Müller, AL, C. Casar, D. Krzikalla, et al. "Inflammatory type 2 conventional dendritic cells contribute to cholangitis in mice." In 37. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber. Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0040-1722075.

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Sakurai, S., K. Furuhashi, R. Horiguchi, et al. "Conventional Type 2 Lung Dendritic Cells in Asthma Mouse Model Significantly Induce Follicular Helper T Cells Than Conventional Type 1." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a7408.

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DeNardo, David G. "Abstract IA011: Conventional dendritic cells as regulators of therapeutic response in pancreas cancer." In Abstracts: AACR Virtual Special Conference: The Evolving Tumor Microenvironment in Cancer Progression: Mechanisms and Emerging Therapeutic Opportunities; in association with the Tumor Microenvironment (TME) Working Group; January 11-12, 2021. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.tme21-ia011.

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Helfer, Brooke M., Anthony Balducci, Pawel Kalinski та Amy Wesa. "Abstract LB-293: Perfluorocarbon labeling of human α-type-1-polarized dendritic cells and conventional dendritic cells for in vivo trafficking by fluorine MRI". У Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-lb-293.

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Grayson, MH, RT Kitchens, and SJ Ehlenbach. "Antigen-Focusing Is Not a Primary Function of IgE on Lung Conventional Dendritic Cells (cDCs)." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a6078.

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Eccles, J. D., S. J. Kim+, K. H. Kim, H. G. Moon, C. Ascoli, and G. Y. Park. "CX3CR1 Expression Defines a Subset of Type 2 Conventional Dendritic Cells." In American Thoracic Society 2024 International Conference, May 17-22, 2024 - San Diego, CA. American Thoracic Society, 2024. http://dx.doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a6683.

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Lin, Jeffrey H., Austin P. Huffman, Emma E. Furth, and Robert H. Vonderheide. "Abstract B31: Type 1 conventional dendritic cells are progressively and systemically dysregulated early in pancreatic carcinogenesis." In Abstracts: AACR Special Conference on Pancreatic Cancer: Advances in Science and Clinical Care; September 6-9, 2019; Boston, MA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.panca19-b31.

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Stravokefalou, Vasiliki, Dimitris Stellas, Sevasti Karaliota, et al. "Abstract 2727: Heterodimeric IL-15 (hetIL-15) affects conventional dendritic cells and a distinct novel dendritic cell population in different mouse cancer models of breast and pancreatic cancer." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-2727.

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Zhang, Xiawei, Shuailin Li, Wojciech Lason, Sophie Morgan, Paul Klenerman, and Timothy Hinks. "MAIT cells contribute to protection against bleomycin-induced lung tissue damage by promoting monocyte differentiation into type 1 conventional dendritic cells." In ERS International Congress 2023 abstracts. European Respiratory Society, 2023. http://dx.doi.org/10.1183/13993003.congress-2023.pa4063.

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Reports on the topic "Conventional dendritic cells"

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Ritprajak, Patcharee, Teerawut Nedumpun, and Sanipa Suradhat. Generation of in vitro porcine monocyte-derived dendritic cells (MoDcs) by new modified protocol. Faculty of Dentistry, Chulalongkorn University, 2016. https://doi.org/10.58837/chula.res.2016.18.

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The derivation of dendritic cells (Des) in vitro is an alternative system to overcome the low frequency of primary DCs and the difficulty of isolation techniques for study of DC immunobiology. To date, conventional culture protocol of porcine monocyte-derived DCs (MoDCs) has been widely used. However, this protocol is sometimes not practical due to the requirement of substantial monocyte number from the blood sample, and the process often interferes with DC maturation. To improve the protocol for porcine MoDC generation, we altered the previous conventional protocol, based on the human MoDC an
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