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Journal articles on the topic 'Conventional dendritic cells'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Audiger, Cindy, and Sylvie Lesage. "Merocytic dendritic cell: a new subset of conventional dendritic cells." Journal of Immunology 202, no. 1_Supplement (2019): 118.11. http://dx.doi.org/10.4049/jimmunol.202.supp.118.11.

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Abstract Conventional dendritic cells (cDC) are potent antigen-presenting cells that induce the activation of naïve T cells in response to pathogens. cDC activity is mediated primarily by two cDC subsets, namely cDC1 and cDC2, each bearing unique properties. Recently, another DC subset, termed merocytic dendritic cells (mcDC), was defined. In contrast to both cDC1 and cDC2, mcDC are able to reverse T cell anergy, even in non-inflammatory conditions, properties that could be exploited to potentiate cancer treatments. Here, we further characterize mcDC to determine their relationship to cDCs. Fi

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Segura, Elodie, June Wong, and José A. Villadangos. "Cutting Edge: B220+CCR9− Dendritic Cells Are Not Plasmacytoid Dendritic Cells but Are Precursors of Conventional Dendritic Cells." Journal of Immunology 183, no. 3 (2009): 1514–17. http://dx.doi.org/10.4049/jimmunol.0901524.

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3

Chow, Kevin V., Andrew M. Lew, Robyn M. Sutherland, and Yifan Zhan. "Monocyte-Derived Dendritic Cells Promote Th Polarization, whereas Conventional Dendritic Cells Promote Th Proliferation." Journal of Immunology 196, no. 2 (2015): 624–36. http://dx.doi.org/10.4049/jimmunol.1501202.

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4

Smrekar, Natasa, David Drobne, Lojze M. Smid, et al. "Dendritic cell profiles in the inflamed colonic mucosa predict the responses to tumor necrosis factor alpha inhibitors in inflammatory bowel disease." Radiology and Oncology 52, no. 4 (2018): 443–52. http://dx.doi.org/10.2478/raon-2018-0045.

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Abstract Background Dendritic cells play crucial roles in the control of inflammation and immune tolerance in the gut. We aimed to investigate the effects of tumor necrosis factor alpha (TNFa) inhibitors on intestinal dendritic cells in patients with inflammatory bowel disease and the potential role of intestinal dendritic cells in predicting the response to treatment. Patients and methods Intestinal biopsies were obtained from 30 patients with inflammatory bowel disease before and after treatment with TNFa inhibitors. The proportions of lamina propria dendritic cell phenotypes were analysed u

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Cabeza-Cabrerizo, Mar, Ana Cardoso, Carlos M. Minutti, Mariana Pereira da Costa, and Caetano Reis e Sousa. "Dendritic Cells Revisited." Annual Review of Immunology 39, no. 1 (2021): 131–66. http://dx.doi.org/10.1146/annurev-immunol-061020-053707.

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Dendritic cells (DCs) possess the ability to integrate information about their environment and communicate it to other leukocytes, shaping adaptive and innate immunity. Over the years, a variety of cell types have been called DCs on the basis of phenotypic and functional attributes. Here, we refocus attention on conventional DCs (cDCs), a discrete cell lineage by ontogenetic and gene expression criteria that best corresponds to the cells originally described in the 1970s. We summarize current knowledge of mouse and human cDC subsets and describe their hematopoietic development and their phenot

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Diao, Jun, Anastassia Mikhailova, Michael Tang, Hongtao Gu, Jun Zhao, and Mark S. Cattral. "Immunostimulatory conventional dendritic cells evolve into regulatory macrophage-like cells." Blood 119, no. 21 (2012): 4919–27. http://dx.doi.org/10.1182/blood-2011-11-392894.

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Abstract Dendritic cell (DC) homeostasis in peripheral tissues reflect a balance between DC generation, migration, and death. The current model of DC ontogeny indicates that pre-cDCs are committed to become terminal conventional DCs (cDCs). Here, we report the unexpected finding that proliferating immunostimulatory CD11c+ MHC class II+ cDCs derived from pre-cDCs can lose their DC identity and generate progeny that exhibit morphologic, phenotypic, and functional characteristics of regulatory macrophages. DC-derived–macrophages (DC-d-Ms) potently suppress T-cell responses through the production

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Velte, T. J., and R. F. Miller. "Spiking and nonspiking models of starburst amacrine cells in the rabbit retina." Visual Neuroscience 14, no. 6 (1997): 1073–88. http://dx.doi.org/10.1017/s0952523800011780.

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AbstractThe integrative properties of starburst amacrine cells in the rabbit retina were studied with compartmental models and computer-simulation techniques. The anatomical basis for these simulations was provided by computer reconstructions of intracellularly stained starburst amacrine cells and published data on dendritic diameter and biophysical properties. Passive and active membrane properties were included to simulate spiking and nonspiking behavior. Simulated synaptic inputs into one or more compartments consisted of a bipolar-like conductance change with peak and steady-state componen

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8

Lee, Jun Seong, Se-Jin Jeong, Sinai Kim, et al. "Conventional Dendritic Cells Impair Recovery after Myocardial Infarction." Journal of Immunology 201, no. 6 (2018): 1784–98. http://dx.doi.org/10.4049/jimmunol.1800322.

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9

Weslow-Schmidt, Janet L., Nancy A. Jewell, Sara E. Mertz, J. Pedro Simas, Joan E. Durbin, and Emilio Flaño. "Type I Interferon Inhibition and Dendritic Cell Activation during Gammaherpesvirus Respiratory Infection." Journal of Virology 81, no. 18 (2007): 9778–89. http://dx.doi.org/10.1128/jvi.00360-07.

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ABSTRACT The respiratory tract is a major mucosal site for microorganism entry into the body, and type I interferon (IFN) and dendritic cells constitute a first line of defense against viral infections. We have analyzed the interaction between a model DNA virus, plasmacytoid dendritic cells, and type I IFN during lung infection of mice. Our data show that murine gammaherpesvirus 68 (γHV68) inhibits type I IFN secretion by dendritic cells and that plasmacytoid dendritic cells are necessary for conventional dendritic cell maturation in response to γHV68. Following γHV68 intranasal inoculation, t

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Edelson, Brian T., Wumesh KC, Richard Juang та ін. "Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells". Journal of Experimental Medicine 207, № 4 (2010): 823–36. http://dx.doi.org/10.1084/jem.20091627.

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Although CD103-expressing dendritic cells (DCs) are widely present in nonlymphoid tissues, the transcription factors controlling their development and their relationship to other DC subsets remain unclear. Mice lacking the transcription factor Batf3 have a defect in the development of CD8α+ conventional DCs (cDCs) within lymphoid tissues. We demonstrate that Batf3−/− mice also lack CD103+CD11b− DCs in the lung, intestine, mesenteric lymph nodes (MLNs), dermis, and skin-draining lymph nodes. Notably, Batf3−/− mice displayed reduced priming of CD8 T cells after pulmonary Sendai virus infection,

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Park, Stacy J., Marie D. Burdick, and Borna Mehrad. "Neutrophils Mediate Maturation and Efflux of Lung Dendritic Cells in Response to Aspergillus fumigatus Germ Tubes." Infection and Immunity 80, no. 5 (2012): 1759–65. http://dx.doi.org/10.1128/iai.00097-12.

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ABSTRACTInvasive aspergillosis is a life-threatening complication of neutrophil deficiency or dysfunction. Neutropenia has previously been associated with enhanced influx of CD11b-expressing conventional dendritic cells to the lungs in response toAspergillusspecies, but whether neutrophils directly modulate the function of dendritic cells in this infection is not known. We hypothesized that, in the setting of intrapulmonary challenge withAspergillus, neutrophils promote the maturation and traffic of lung conventional dendritic cells to draining mediastinal lymph nodes. We report that neutropen

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Tschernig, Thomas, Christina Hartwig, Andreas Jeron, Quoc Thai Dinh, Marcus Gereke, and Dunja Bruder. "First Genomic Analysis of Dendritic Cells from Lung and Draining Lymph Nodes in Murine Asthma." International Journal of Genomics 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/638032.

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Asthma is the consequence of allergic inflammation in the lung compartments and lung-draining lymph nodes. Dendritic cells initiate and promote T cell response and drive it to immunity or allergy. However, their modes of action during asthma are poorly understood. In this study, an allergic inflammation with ovalbumin was induced in 38 mice versus 42 control animals. After ovalbumin aerosol challenge, conventional dendritic cells (CD11c/MHCII/CD8) were isolated from the lungs and the draining lymph nodes by means of magnetic cell sorting followed by fluorescence-activated cell sorting. A compa

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Fu, Chunmei, Peng Peng, Jakob Loschko, et al. "Plasmacytoid dendritic cells cross-prime naive CD8 T cells by transferring antigen to conventional dendritic cells through exosomes." Proceedings of the National Academy of Sciences 117, no. 38 (2020): 23730–41. http://dx.doi.org/10.1073/pnas.2002345117.

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Although plasmacytoid dendritic cells (pDCs) have been shown to play a critical role in generating viral immunity and promoting tolerance to suppress antitumor immunity, whether and how pDCs cross-prime CD8 T cells in vivo remain controversial. Using a pDC-targeted vaccine model to deliver antigens specifically to pDCs, we have demonstrated that pDC-targeted vaccination led to strong cross-priming and durable CD8 T cell immunity. Surprisingly, cross-presenting pDCs required conventional DCs (cDCs) to achieve cross-priming in vivo by transferring antigens to cDCs. Taking advantage of an in vitr

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van der Sluis, Renée M., Juan L. García-Rodríguez, Ian Helstrup Nielsen, et al. "Distinctive CD8+ T cell activation by antigen-presenting plasmacytoid dendritic cells compared to conventional dendritic cells." Cell Reports 44, no. 3 (2025): 115413. https://doi.org/10.1016/j.celrep.2025.115413.

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15

Smit, Joost J., Brian D. Rudd, and Nicholas W. Lukacs. "Plasmacytoid dendritic cells inhibit pulmonary immunopathology and promote clearance of respiratory syncytial virus." Journal of Experimental Medicine 203, no. 5 (2006): 1153–59. http://dx.doi.org/10.1084/jem.20052359.

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Respiratory syncytial virus (RSV) infection is widely spread and is a major cause of bronchiolitis in infants and high-risk adults, often leading to hospitalization. RSV infection leads to obstruction and inflammation of the airways and induction of innate and acquired immune responses. Because dendritic cells (DCs) are essential in the elicitation of these immune responses, we investigated the presence and the role of dendritic cell subtypes upon RSV infection in the lung. Here, we report that RSV infection increased the number of both conventional and plasmacytoid dendritic cells in the lung

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16

Audiger, Cindy, Adrien Fois, Alyssa L. Thomas, Edith Janssen, Martin Pelletier, and Sylvie Lesage. "Merocytic Dendritic Cells Compose a Conventional Dendritic Cell Subset with Low Metabolic Activity." Journal of Immunology 205, no. 1 (2020): 121–32. http://dx.doi.org/10.4049/jimmunol.1900970.

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17

Hemati, Behzad, Vanessa Contreras, Céline Urien, et al. "Bluetongue Virus Targets Conventional Dendritic Cells in Skin Lymph." Journal of Virology 83, no. 17 (2009): 8789–99. http://dx.doi.org/10.1128/jvi.00626-09.

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ABSTRACT Bluetongue virus (BTV) is the etiological agent of bluetongue, a hemorrhagic disease of ruminants (particularly sheep), which causes important economic losses around the world. BTV is transmitted primarily via the bites of infected midges, which inject the virus into the ruminant's skin during blood feeding. The virus initially replicates in the draining lymph node and then disseminates to secondary organs where it induces edema, hemorrhages, and necrosis. In this study, we show that ovine conventional dendritic cells (cDCs) are the primary targets of BTV that contribute to the primar

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18

Izumi, Gentaro, Keiko Nakano, Seddon Y. Thomas, et al. "Ly-6C+CD11b+conventional dendritic cells accumulate in inflamed lung and differentiate into type 2 dendritic cells." Journal of Immunology 202, no. 1_Supplement (2019): 119.23. http://dx.doi.org/10.4049/jimmunol.202.supp.119.23.

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Abstract Allergic asthma is a complex inflammatory disease characterized by airway obstruction and airway hyperresponsiveness. Pulmonary dendritic cells are critical for allergic sensitization as they take up inhaled allergens and direct differentiation of allergen-specific helper T cell lineages in lung-draining lymph nodes. In this study, we used mass cytometry to study lung DC subsets that increase in frequency after allergen inhalation. This approach revealed a novel cell population displaying Ly-6C, in addition to surface markers routinely used to identify type 2 conventional DCs (cDC2),

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19

Vremec, David, Meredith O'Keeffe, Hubertus Hochrein, et al. "Production of interferons by dendritic cells, plasmacytoid cells, natural killer cells, and interferon-producing killer dendritic cells." Blood 109, no. 3 (2006): 1165–73. http://dx.doi.org/10.1182/blood-2006-05-015354.

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Abstract The capacity of mouse spleen conventional dendritic cells (cDCs) and plasmacytoid dendritic cells (pDCs) to produce interferon-γ (IFN-γ) or IFN-α was assessed, and compared with that of natural killer (NK) cells and the recently identified interferon-producing killer dendritic cells (IKDCs), both of which are frequent contaminants in DC preparations. Fully developed cDCs or pDCs, if free of NK cells or IKDCs, showed little capacity for IFN-γ production. However, an early developmental form of the CD4−8+ cDC subtype, and the Ly6C− Ly49Q− pDC subtype, both were able to produce moderate

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20

Song, Runqiu, Mariam Bafit, Kirsteen M. Tullett, et al. "A Simple and Rapid Protocol for the Isolation of Murine Bone Marrow Suitable for the Differentiation of Dendritic Cells." Methods and Protocols 7, no. 2 (2024): 20. http://dx.doi.org/10.3390/mps7020020.

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The generation of bone-marrow-derived dendritic cells is a widely used approach in immunological research to study antigen processing and presentation, as well as T-cell activation responses. However, the initial step of isolating the bone marrow can be time-consuming, especially when larger numbers of precursor cells are required. Here, we assessed whether an accelerated bone marrow isolation method using centrifugation is suitable for the differentiation of FMS-like tyrosine kinase 3 ligand-driven dendritic cells. Compared to the conventional flushing method, the centrifugation-based isolati

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Harfuddin, Zulkarnain, Shaqireen Kwajah, Adrian Chong Nyi Sim, Paul Anthony MacAry, and Herbert Schwarz. "CD137L-stimulated dendritic cells are more potent than conventional dendritic cells at eliciting cytotoxic T-cell responses." OncoImmunology 2, no. 11 (2013): e26859. http://dx.doi.org/10.4161/onci.26859.

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22

Siegemund, Sabine, and Gottfried Alber. "Cryptococcus neoformansactivates bone marrow-derived conventional dendritic cells rather than plasmacytoid dendritic cells and down-regulates macrophages." FEMS Immunology & Medical Microbiology 52, no. 3 (2008): 417–27. http://dx.doi.org/10.1111/j.1574-695x.2008.00391.x.

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23

Zhang, Min, Bradford E. Berndt, Brian M. Gray, and John Y. Kao. "418 H. pylori Stimulated Conventional Dendritic Cells Retained Toleragenicity of Immature Dendritic Cells While Upregulating Proinflammatory Cytokines." Gastroenterology 134, no. 4 (2008): A—59. http://dx.doi.org/10.1016/s0016-5085(08)60280-2.

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24

Wada, Hiroka, Takashi Mawatari, Yasuo Saito, Naoki Azuma, and Yoshitaka Iwama. "Lactobacillus helveticus Induces Two Types of Dendritic Cell Activation and Effectively Suppresses Onset of the Common Cold: A Randomized, Double-Blind, Placebo-Controlled Trial." Nutrients 17, no. 1 (2024): 101. https://doi.org/10.3390/nu17010101.

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Background/Objectives: Lactobacillus helveticus GCL1815 is a lactic acid bacterium thought to activate dendritic cells. This randomized, placebo-controlled, double-blind study aimed to evaluate the effects of L. helveticus GCL1815 on human dendritic cells and the onset of the common cold. Methods: Two hundred participants were divided into two groups and took capsules containing either six billion L. helveticus GCL1815 cells or placebo for 8 weeks. Results: In the GCL1815 group, the cumulative incidence days of symptoms such as feverishness, fatigue, tiredness, runny nose, nasal congestion, an

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Movassagh, Hesam, Lianyu Shan, Latifa Koussih, et al. "Semaphorin 3E deficiency dysregulates dendritic cell functions: In vitro and in vivo evidence." PLOS ONE 16, no. 6 (2021): e0252868. http://dx.doi.org/10.1371/journal.pone.0252868.

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Regulation of dendritic cell functions is a complex process in which several mediators play diverse roles as a network in a context-dependent manner. The precise mechanisms underlying dendritic cell functions have remained to be addressed. Semaphorins play crucial roles in regulation of various cell functions. We previously revealed that Semaphorin 3E (Sema3E) contributes to regulation of allergen-induced airway pathology partly mediated by controlling recruitment of conventional dendritic cell subsets in vivo, though the underlying mechanism remained elusive. In this study, we investigate the

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KHRANOVSKAYA, NATALYA, VALERII OREL, YURIY GRINEVICH, et al. "MECHANICAL HETEROGENIZATION OF LEWIS LUNG CARCINOMA CELLS CAN IMPROVE ANTIMETASTATIC EFFECT OF DENDRITIC CELLS." Journal of Mechanics in Medicine and Biology 12, no. 03 (2012): 1250037. http://dx.doi.org/10.1142/s0219519411004757.

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The effect of mechanically heterogenized (MCH) microparticles of tumor cells (TCs) on antimetastatic action of dendritic cells (DCs) is studied in C57BL/6 mice with Lewis' carcinoma. DCs isolated from mice spleens and loaded with MCH-TCs are analyzed with flow cytometry methods. MCH-TCs are analyzed with optical and/or electron microscopy. The paper describes an original high-precision medical microvibromill with high-acceleration linear induction motor that generates magnetic levitation to produce mechanical heterogenization of TCs. MCH-TCs have a more asymmetric morphology, larger surface an

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Nagaharu, Keiki, Kohshi Ohishi, and Naoyuki Katayama. "Novel Lymphoid Pathway of Human Plasmacytoid and Conventional Dendritic Cells." Blood 134, Supplement_1 (2019): 4998. http://dx.doi.org/10.1182/blood-2019-121448.

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[Introduction] Dendritic cells (DCs) play a central role in initiation and regulation of immune response. Human plasmacytoid DCs (pDCs) as well as conventional DCs (cDCs) were shown to differentiate from multi-lymphoid progenitors (MLPs) as well as myeloid progenitors via common DC progenitors. However, lymphoid pathway of DCs remained clarified. Here we investigated lymphoid origin of DCs, using a novel co-culture system which supports differentiation of various lineages of lymphoid and DCs (Br J Haematol. 157:674, 2012; J Immunol. 199:2343, 2017). [Methods and Results] CD34+CD38-CD45RA-CD10-

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Adachi, Ryosuke, and Takahiko Tamura. "Plasmodium infection cure cycles induce modulation of conventional dendritic cells." Microbiology and Immunology 64, no. 5 (2020): 377–86. http://dx.doi.org/10.1111/1348-0421.12783.

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Yan, Hao, Xiangyue Zhang, Jeanette Baker, Edgar G. Engleman, and Robert S. Negrin. "Erythropoietin Promotes GvHD Prevention through Type 1 Conventional Dendritic Cells." Blood 144, Supplement 1 (2024): 2012. https://doi.org/10.1182/blood-2024-194522.

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Allogeneic hematopoietic cell transplantation (HCT) is a proven treatment for hematologic malignancies; however, it is associated with significant morbidity and mortality due to complications such as graft-versus-host disease (GVHD). GVHD occurs when donor T cells react against recipient antigens (Ags) presented by Ag-presenting cells (APCs), with dendritic cells (DCs) playing a crucial role in this process. Treatment with apoptotic cells (ACs) induced by extracorporeal photopheresis (ECP) has been successful in reducing acute and chronic GVHD, especially in patients unresponsive to standard i

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Mussá, Tufária, Carolina Rodriguez-Cariño, Myriam Pujol, et al. "Interaction of porcine conventional dendritic cells with swine influenza virus." Virology 420, no. 2 (2011): 125–34. http://dx.doi.org/10.1016/j.virol.2011.09.001.

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Shakir, E., S. J. Ehlenbach та M. H. Grayson. "Decay of FcεRI Expression on Murine Lung Conventional Dendritic Cells". Journal of Allergy and Clinical Immunology 125, № 2 (2010): AB228. http://dx.doi.org/10.1016/j.jaci.2009.12.892.

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32

Calmeiro, João, Mylène A. Carrascal, Adriana Ramos Tavares, et al. "Dendritic Cell Vaccines for Cancer Immunotherapy: The Role of Human Conventional Type 1 Dendritic Cells." Pharmaceutics 12, no. 2 (2020): 158. http://dx.doi.org/10.3390/pharmaceutics12020158.

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Throughout the last decades, dendritic cell (DC)-based anti-tumor vaccines have proven to be a safe therapeutic approach, although with inconsistent clinical results. The functional limitations of ex vivo monocyte-derived dendritic cells (MoDCs) commonly used in these therapies are one of the pointed explanations for their lack of robustness. Therefore, a great effort has been made to identify DC subsets with superior features for the establishment of effective anti-tumor responses and to apply them in therapeutic approaches. Among characterized human DC subpopulations, conventional type 1 DCs

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Fancke, Ben, Mark Suter, Hubertus Hochrein, and Meredith O'Keeffe. "M-CSF: a novel plasmacytoid and conventional dendritic cell poietin." Blood 111, no. 1 (2008): 150–59. http://dx.doi.org/10.1182/blood-2007-05-089292.

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The critical importance of plasmacytoid dendritic cells (pDCs) in viral infection, autoimmunity, and tolerance has focused major attention on these cells that are rare in blood and immune organs of humans and mice. The recent development of an Flt-3 ligand (FL) culture system of bone marrow cells has led to the simple generation of large numbers of pDCs that resemble their in vivo steady-state counterparts. The FL system has allowed unforeseen insight into the biology of pDCs, and it is assumed that FL is the crucial growth factor for these cells. Surprisingly we have found that a cell type wi

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Won, Haejung, Yuchia Chou, Tao Wang, Lindsey Jones, Xue Huang, and Si-Yi Chen. "Histone H2A deubiquitinase MYSM1 is essential for dendritic cell development (P4488)." Journal of Immunology 190, no. 1_Supplement (2013): 52.61. http://dx.doi.org/10.4049/jimmunol.190.supp.52.61.

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Abstract The mechanisms controlling differentiation of dendritic cells remain largely unknown. Using knockout mouse model, we identified Mysm1 as a critical regulator in dendritic cell differentiation. Mysm1 knockout mice showed a global reduction of both conventional dendritic cells and plasmacytoid dendritic cells in lymphoid organs and non-lymphoid organs whereas development of granulocyte and macrophage was not severely affected. Hematopoietic progenitors and dendritic cell precursors were significantly decreased in KO mice, and the precursor cells from Mysm1 knockout mice were unable to d

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Steiner, Quynh-Giao, Luc A. Otten, M. John Hicks та ін. "In vivo transformation of mouse conventional CD8α+ dendritic cells leads to progressive multisystem histiocytosis". Blood 111, № 4 (2008): 2073–82. http://dx.doi.org/10.1182/blood-2007-06-097576.

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Division and proliferation of dendritic cells (DCs) have been proposed to contribute to homeostasis and to prolonged antigen presentation. Whether abnormal proliferation of dendritic cells causes Langerhans cell histiocytosis (LCH) is a highly debated topic. Transgenic expression of simian virus 40 (SV40) T antigens in mature DCs allowed their transformation in vivo while maintaining their phenotype, function, and maturation capacity. The transformed cells were differentiated splenic CD8 alpha–positive conventional dendritic cells with increased Langerin expression. Their selective transformat

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Li, Hongmei, Anthony J. Demetris, Jennifer McNiff, et al. "Profound Depletion of Host Conventional Dendritic Cells, Plasmacytoid Dendritic Cells, and B Cells Does Not Prevent Graft-versus-Host Disease Induction." Journal of Immunology 188, no. 8 (2012): 3804–11. http://dx.doi.org/10.4049/jimmunol.1102795.

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Abe, K., K. P. Nguyen, S. D. Fine, et al. "Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells." Proceedings of the National Academy of Sciences 104, no. 43 (2007): 17022–27. http://dx.doi.org/10.1073/pnas.0708469104.

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Schroth, Samantha L., Rebecca T. L. Jones, and Edward B. Thorp. "Alloantigen Infusion Activates the Transcriptome of Type 2 Conventional Dendritic Cells." ImmunoHorizons 7, no. 10 (2023): 683–93. http://dx.doi.org/10.4049/immunohorizons.2300067.

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Abstract Recent studies have revealed novel molecular mechanisms by which innate monocytic cells acutely recognize and respond to alloantigen with significance to allograft rejection and tolerance. What remains unclear is the single-cell heterogeneity of the innate alloresponse, particularly the contribution of dendritic cell (DC) subsets. To investigate the response of these cells to exposure of alloantigen, C57BL/6J mice were administered live allogenic BALB/cJ splenic murine cells versus isogenic cells. In parallel, we infused apoptotic allogenic and isogenic cells, which have been reported

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Murayama, Masanori, Enrique Pérez-Garci, Hans-Rudolf Lüscher, and Matthew E. Larkum. "Fiberoptic System for Recording Dendritic Calcium Signals in Layer 5 Neocortical Pyramidal Cells in Freely Moving Rats." Journal of Neurophysiology 98, no. 3 (2007): 1791–805. http://dx.doi.org/10.1152/jn.00082.2007.

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Calcium influx into the dendritic tufts of layer 5 neocortical pyramidal neurons modifies a number of important cellular mechanisms. It can trigger local synaptic plasticity and switch the firing properties from regular to burst firing. Due to methodological limitations, our knowledge about Ca2+ spikes in the dendritic tuft stems mostly from in vitro experiments. However, it has been speculated that regenerative Ca2+ events in the distal dendrites correlate with distinct behavioral states. Therefore it would be most desirable to be able to record these Ca2+ events in vivo, preferably in the be

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Javier-Torrent, Míriam, and Carlos A. Saura. "Conventional and Non-Conventional Roles of Non-Muscle Myosin II-Actin in Neuronal Development and Degeneration." Cells 9, no. 9 (2020): 1926. http://dx.doi.org/10.3390/cells9091926.

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Myosins are motor proteins that use chemical energy to produce mechanical forces driving actin cytoskeletal dynamics. In the brain, the conventional non-muscle myosin II (NMII) regulates actin filament cytoskeletal assembly and contractile forces during structural remodeling of axons and dendrites, contributing to morphology, polarization, and migration of neurons during brain development. NMII isoforms also participate in neurotransmission and synaptic plasticity by driving actin cytoskeletal dynamics during synaptic vesicle release and retrieval, and formation, maturation, and remodeling of

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Brand, Jeffrey, Joel Mathews, David Kasahara, Felippe Neto, and Stephanie Shore. "Oxidative stress-induced pulmonary neutrophil recruitment is independent of conventional dendritic cells (INC5P.325)." Journal of Immunology 192, no. 1_Supplement (2014): 120.5. http://dx.doi.org/10.4049/jimmunol.192.supp.120.5.

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Abstract Oxidative stress and airway neutrophilia are key features of some asthma phenotypes. Ozone (O3), a potent oxidant, induces pulmonary neutrophil recruitment which requires IL-17A+ γδ T cells. IL-23 is required for IL-17A production by T cells and conventional dendritic cells (cDC) are a potent source of IL-23. We therefore hypothesized that oxidative stress-induced IL-17A+ γδ T cells require IL-23 production from cDC. Wild type (WT), Tcrd-/- (lacking γδ T cells), and flt3l-/- (deficient in cDC) mice were exposed to air or 0.3 ppm O3 for 72 h. Bronchoalveolar lavage (BAL) was collected

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Bourque, Jessica, and Daniel Hawiger. "Applications of Antibody-Based Antigen Delivery Targeted to Dendritic Cells In Vivo." Antibodies 11, no. 1 (2022): 8. http://dx.doi.org/10.3390/antib11010008.

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Recombinant immunoglobulins, derived from monoclonal antibodies recognizing the defined surface epitopes expressed on dendritic cells, have been employed for the past two decades to deliver antigens to dendritic cells in vivo, serving as critical tools for the investigation of the corresponding T cell responses. These approaches originated with the development of the recombinant chimeric antibody against a multilectin receptor, DEC-205, which is present on subsets of murine and human conventional dendritic cells. Following the widespread application of antigen targeting through DEC-205, simila

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Carranza, Paloma, Perla M. Del Río Estrada, Dafne Díaz Rivera, Yuria Ablanedo-Terrazas, and Gustavo Reyes-Terán. "Lymph nodes from HIV-infected individuals harbor mature dendritic cells and increased numbers of PD-L1+ conventional dendritic cells." Human Immunology 77, no. 7 (2016): 584–93. http://dx.doi.org/10.1016/j.humimm.2016.05.019.

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Felker, Piritta, Kristin Seré, Qiong Lin та ін. "TGF-β1 Accelerates Dendritic Cell Differentiation from Common Dendritic Cell Progenitors and Directs Subset Specification toward Conventional Dendritic Cells". Journal of Immunology 185, № 9 (2010): 5326–35. http://dx.doi.org/10.4049/jimmunol.0903950.

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Plantinga, Maud, Denise A. M. H. van den Beemt, Ester Dünnebach, and Stefan Nierkens. "CD14 Expressing Precursors Give Rise to Highly Functional Conventional Dendritic Cells for Use as Dendritic Cell Vaccine." Cancers 13, no. 15 (2021): 3818. http://dx.doi.org/10.3390/cancers13153818.

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Induction of long-lasting immunity by dendritic cells (DCs) makes them attractive candidates for anti-tumor vaccination. Although DC vaccinations are generally considered safe, clinical responses remain inconsistent in clinical trials. This initiated studies to identify subsets of DCs with superior capabilities to induce effective and memory anti-tumor responses. The use of primary DCs has been suggested to overcome the functional limitations of ex vivo monocyte-derived DCs (moDC). The ontogeny of primary DCs has recently been revised by the introduction of DC3, which phenotypically resembles

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Jacobsen, Johanne, Karoline Schjetne, Ludvig Munthe, and Bjarne Bogen. "Naïve anti-Id B cells and Id-specific CD4+ T cells collaborate efficiently to non infectious antigens in the absence of dendritic cells. (122.12)." Journal of Immunology 188, no. 1_Supplement (2012): 122.12. http://dx.doi.org/10.4049/jimmunol.188.supp.122.12.

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Abstract It is thought that activated dendritic cells are needed for induction of T cell responses. However, this makes it difficult to explain immune responses to self-like molecules such as allotypes and idiotypes where no activation of dendritic cells should be involved. We have here generated a double knock-in mouse that expresses prearranged H and L chain V regions of an anti-Id B cell receptor (BCR). By use of anti-Id B cells from this mouse, together with Id-specific CD4+ T cells from T cell receptor (TCR)-transgenic mice, we show that induction of isotype-switched anti-Id Abs depends o

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Ishikawa, Fumihiko, Tadafumi Iino, Hiroaki Niiro, et al. "Human Conventional and Plasmacytoid Dendritic Cells Can Originate from Both Lymphoid and Myeloid Progenitors in a New Humanized Mouse System." Blood 106, no. 11 (2005): 2273. http://dx.doi.org/10.1182/blood.v106.11.2273.2273.

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Abstract Dendritic cells play a key role in host defense by presenting exogenous antigens to T cells. Two dendritic cell subsets, conventional dendritic cells (cDCs) and plasmacytoid dendritic cells (pDCs), express distinct repertoire of Toll-like-receptors and recognize different antigens. We previously reported that murine cDCs and pDCs differentiate via either the myeloid or the lymphoid pathway (Shigematsu et al. Immunity ). It is, however, still unclear whether human cDCs and pDCs develop from myeloid, lymphoid or both lineages. In order to analyze the in vivo differentiation of human den

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Chrisikos, Taylor T., Yifan Zhou, Laura M. Kahn, et al. "STAT3 Inhibits Autocrine IFN Signaling in Type I Conventional Dendritic Cells." Journal of Immunology 209, no. 7 (2022): 1286–99. http://dx.doi.org/10.4049/jimmunol.2101104.

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Weimershaus, Mirjana, Sophia Maschalidi, Fernando Sepulveda, Bénédicte Manoury, Peter van Endert, and Loredana Saveanu. "Conventional Dendritic Cells Require IRAP-Rab14 Endosomes for Efficient Cross-Presentation." Journal of Immunology 188, no. 4 (2012): 1840–46. http://dx.doi.org/10.4049/jimmunol.1101504.

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Mancuso, Giuseppe, Maria Gambuzza, Angelina Midiri, et al. "Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells." Nature Immunology 10, no. 6 (2009): 587–94. http://dx.doi.org/10.1038/ni.1733.

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