Relevant bibliographies by topics / COPD control

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'COPD control'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "COPD control"

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Agusti, Alvar, and William MacNee. "The COPD control panel: towards personalised medicine in COPD." Thorax 68, no. 7 (November 1, 2012): 687–90. http://dx.doi.org/10.1136/thoraxjnl-2012-202772.

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WALSH, NANCY. "Combination Treatment Bolsters COPD Control." Family Practice News 38, no. 13 (July 2008): 37. http://dx.doi.org/10.1016/s0300-7073(08)70832-6.

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Behlau, Franklin, Blanca I. Canteros, Gerald V. Minsavage, Jeffrey B. Jones, and James H. Graham. "Molecular Characterization of Copper Resistance Genes from Xanthomonas citri subsp.citriand Xanthomonas alfalfae subsp. citrumelonis." Applied and Environmental Microbiology 77, no. 12 (April 22, 2011): 4089–96. http://dx.doi.org/10.1128/aem.03043-10.

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ABSTRACTCopper sprays have been widely used for control of endemic citrus canker caused byXanthomonas citrisubsp.citriin citrus-growing areas for more than 2 decades.Xanthomonas alfalfaesubsp.citrumelonispopulations were also exposed to frequent sprays of copper for several years as a protective measure against citrus bacterial spot (CBS) in Florida citrus nurseries. Long-term use of these bactericides has led to the development of copper-resistant (Cur) strains in bothX. citrisubsp.citriandX. alfalfaesubsp.citrumelonis, resulting in a reduction of disease control. The objectives of this study were to characterize for the first time the genetics of copper resistance inX. citrisubsp.citriandX. alfalfaesubsp.citrumelonisand to compare these organisms to other Curbacteria. Copper resistance determinants fromX. citrisubsp.citristrain A44(pXccCu2) from Argentina andX. alfalfaesubsp.citrumelonisstrain 1381(pXacCu2) from Florida were cloned and sequenced. Open reading frames (ORFs) related to the genescopL,copA,copB,copM,copG,copC,copD, andcopFwere identified inX. citrisubsp.citriA44. The same ORFs, exceptcopCandcopD, were also present inX. alfalfaesubsp.citrumelonis1381. Transposon mutagenesis of the cloned copper resistance determinants in pXccCu2 revealed that copper resistance inX. citrisubsp.citristrain A44 is mostly due tocopL,copA, andcopB, which are the genes in the cloned cluster with the highest nucleotide homology (≥92%) among different Curbacteria.
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WALSH, NANCY. "Combination Treatment Improved Control in COPD." Internal Medicine News 41, no. 19 (October 2008): 26. http://dx.doi.org/10.1016/s1097-8690(08)71092-8.

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Jenkins, Christine R. "Bringing COPD control into the consultation." Respirology 25, no. 11 (July 12, 2020): 1110–11. http://dx.doi.org/10.1111/resp.13884.

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Layec, Gwenael, Luke J. Haseler, Jan Hoff, and Russell S. Richardson. "Evidence that a higher ATP cost of muscular contraction contributes to the lower mechanical efficiency associated with COPD: preliminary findings." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 300, no. 5 (May 2011): R1142—R1147. http://dx.doi.org/10.1152/ajpregu.00835.2010.

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Impaired metabolism in peripheral skeletal muscles potentially contributes to exercise intolerance in chronic obstructive pulmonary disease (COPD). We used 31P-magnetic resonance spectroscopy (31P-MRS) to examine the energy cost and skeletal muscle energetics in six patients with COPD during dynamic plantar flexion exercise compared with six well-matched healthy control subjects. Patients with COPD displayed a higher energy cost of muscle contraction compared with the controls (control: 6.1 ± 3.1% of rest·min−1·W−1, COPD: 13.6 ± 8.3% of rest·min−1·W−1, P = 0.01). Although, the initial phosphocreatine resynthesis rate was also significantly attenuated in patients with COPD compared with controls (control: 74 ± 17% of rest/min, COPD: 52 ± 13% of rest/min, P = 0.04), when scaled to power output, oxidative ATP synthesis was similar between groups (6.5 ± 2.3% of rest·min−1·W−1 in control and 7.8 ± 3.9% of rest·min−1·W−1 in COPD, P = 0.52). Therefore, our results reveal, for the first time that in a small subset of patients with COPD a higher ATP cost of muscle contraction may substantially contribute to the lower mechanical efficiency previously reported in this population. In addition, it appears that some patients with COPD have preserved mitochondrial function and normal energy supply in lower limb skeletal muscle.
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Karametos, Ilias, Paraskevi Tsiboli, Ilias Togousidis, Chrisi Hatzoglou, Grigorios Giamouzis, and Konstantinos Gourgoulianis. "Chronic Obstructive Pulmonary Disease as a Main Factor of Premature Aging." International Journal of Environmental Research and Public Health 16, no. 4 (February 13, 2019): 540. http://dx.doi.org/10.3390/ijerph16040540.

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(1) Background: Chronic obstructive pulmonary disease (COPD) is defined as an inflammatory disorder that presents an increasingly prevalent health problem. Accelerated aging has been examined as a pathologic mechanism of many chronic diseases like COPD. We examined whether COPD is combined with accelerated aging, studying two hormones, dehydroepiandrosterone (DHEA) and growth hormone (GH), known to be characteristic biological markers of aging. (2) Methods: Data were collected from 119 participants, 70 (58.8%) COPD patients and 49 (41.2%) from a health control group over the period of 2014–2016 in a spirometry program. Information about their medical history, tobacco use, and blood tests was obtained. (3) Results: The average age of the health control patients was 73.5 years (SD = 5.5), and that of the COPD patients was 75.4 years (SD = 6.9). Both groups were similar in age and sex. A greater proportion of smokers were found in the COPD group (87.1%) versus the control group (36.7%). The majority of COPD patients were classified as STAGE II (51.4%) and STAGE III (37.1%) according to GOLD (Global Initiative for Chronic Obstructive Pulmonary Disease). Levels of DHEA (SD = 17.1) and GH (SD = 0.37) were significantly lower in the COPD group (p < 0.001) compared to those in the controls (SD = 26.3, SD = 0.79). DHEA and GH were more significant and negatively correlated with age. The regression equation of DHEA with age produced a coefficient equal to 1.26. In this study, the difference in DHEA between COPD patients and controls was, on average, 30.2 μg/dL, indicating that the biological age of a COPD patient is on average about 24 years older than that of a control subject of the same age. Similarly, the difference in GH between COPD patients and controls was, on average, 0.42 ng/mL, indicating that the biological age of a COPD patient is on average about 13.1 years older than that of a control subject of the same age. (4) Conclusions: The findings of our study strongly suggest the presence of premature biological aging in COPD patients. Their biological age could actually vary from 13 to 23 years older than non-COPD controls according to DHEA and GH variation.
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Plans-Rubió, Pedro. "Prevention and control of influenza in persons with chronic obstructive pulmonary disease." International Journal of COPD 2, no. 1 (March 2007): 41–53. http://dx.doi.org/10.2147/copd.2007.2.1.41.

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Mandell, Brian F. "COPD: More options mean potentially better control." Cleveland Clinic Journal of Medicine 81, no. 6 (June 2014): 332–34. http://dx.doi.org/10.3949/ccjm.81b.06014.

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Hara, Hiromichi, Kazuyoshi Kuwano, and Jun Araya. "Mitochondrial Quality Control in COPD and IPF." Cells 7, no. 8 (July 24, 2018): 86. http://dx.doi.org/10.3390/cells7080086.

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Mitochondria play important roles in the maintenance of intracellular homeostasis; hence, the quality control of mitochondria is crucial for cell fate determination. Mitochondria dynamics and mitochondria-specific autophagy, known as mitophagy, are two main quality control systems in cells. Mitochondria fuse to increase energy production in response to stress, and damaged mitochondria are segregated by fission and degraded by mitophagy. Once these systems are disrupted, dysfunctional mitochondria with decreased adenosine triphosphate (ATP) production and increased reactive oxygen species (ROS) production accumulate, affecting cell fate. Recently, increasing evidence suggests that the dysregulation of mitochondria quality control is pathogenic in several age-related diseases. In this review, we outlined the role of mitochondria quality control systems in the pathogenesis of age-associated lung diseases, chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF).
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Dissertations / Theses on the topic "COPD control"

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Gerhards, Claudia [Verfasser]. "Rhino-Sinusitis is a frequent problem in COPD : A case-control study / Claudia Gerhards." München : GRIN Verlag, 2015. http://d-nb.info/1184213879/34.

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Arkstål, Emil. "Interactive Analytics and Visualization for Data Driven Calculation of Individualized COPD Risk." Thesis, Linköpings universitet, Interaktiva och kognitiva system, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-151925.

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Chronic obstructive pulmonary disease (COPD) is a high mortality disease, second to stroke and ischemic heart disease. This non-curable disease progressively exacerbates, leading to high personal and societal economic impact, reduced quality of life and often death. General treatment plans for COPD risk mistreating the individuals’ condition. To be effective, the treatment should be individualized following the practices of precision medicine. The aim of this thesis was to develop a data driven algorithm and system with visualization to assess individual COPD risk. With MRI body composition profile measurements, it is possible to accurately assess propensity of a multitude of metabolic conditions, such as coronary heart disease and type 2 diabetes.  The algorithm and system has been developed using Wolfram Language and R within the Wolfram Mathematica framework. The algorithm calculates individualized virtual control groups metabolically similar to the patient’s body composition and spirometric profile. Using UK Biobank data, our tool was used to assess patient COPD propensity using an individual-specific virtual control group with AUROC 0.778 (female) and 0.758 (men). Additionally, the tool was used to identify new body composition profiles related to COPD and associated comorbid conditions.
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Gau, Jen-Tzer, Utkarsh H. Acharya, M. Salman Khan, and Tzu-Cheg Kao. "Risk factors associated with lower defecation frequency in hospitalized older adults: a case control study." BioMed Central Ltd, 2015. http://hdl.handle.net/10150/610289.

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BACKGROUND: Constipation is highly prevalent in older adults and may be associated with greater frequency of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). We investigated the prevalence of lower defecation frequency (DF) and risk factors (including AECOPD) associated with lower DF among hospitalized elderly patients. METHODS: We conducted a retrospective case-control study in a community hospital of Southeast Ohio. Adults aged 65 years or older admitted during 2004 and 2006 were reviewed (N = 1288). Patients were excluded (N = 212) if their length of stay was less than 3 days, discharge diagnosis of Clostridium difficile-associated diarrhea, death or ventilator- dependent respiratory failure during hospitalization. Lower DF was defined as either an average DF of 0.33 or less per day or no defecation in the first three days of hospitalization; cases (N = 406) and controls (N = 670) were included for the final analysis. RESULTS: Approximately 38% had lower DF in this patient population. Fecal soiling/smearing of at least two episodes was documented in 7% of the patients. With the adjustment of confounders, AECOPD (adjusted odds ratio [AOR] =1.47, 95% confidence interval [CI] =1.01-2.13) and muscle relaxant use (AOR =2.94; 95% CI =1.29-6.69) were significantly associated with lower DF. Supplementation of potassium and antibiotic use prior to hospitalization was associated with lower risk of lower DF. CONCLUSIONS: Approximately 38% of hospitalized older adults had lower DF. AECOPD and use of muscle relaxant were significantly associated with lower DF; while supplementation of potassium and antibiotic use were protective for lower DF risk after adjusting for other variables.
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Tatari, Wisam. "Using Pharmacist-Led Tele-Consultation to Review Patients with Chronic Obstructive Pulmonary Disease." Thesis, University of Bradford, 2018. http://hdl.handle.net/10454/17311.

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Akiki, Zeina. "Biological Markers For Chronic Obstructive Pulmonary Disease And Asthma." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS081/document.

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L’étude des marqueurs biologiques dans la broncho-pneumopathie chronique obstructive (BPCO) et l'asthme, deux maladies respiratoires chroniques affectant des millions de personnes dans le monde, pourrait améliorer leur diagnostic, leur traitement et leur prévention.Cette thèse comprend deux parties. La première visait à évaluer l'association entre un marqueur spécifique des poumons, la protéine surfactant D (SP-D) sérique, et la BPCO, et à trouver un seuil de SP-D capable de discriminer les patients BPCO des témoins. Elle a été réalisée dans le cadre d’une étude cas-témoin au Liban incluant des patients BPCO (n=90), des asthmatiques (n=124) et des témoins (n=180). La deuxième partie visait à évaluer les associations chez les adultes des marqueurs de l’inflammation systémique (protéine C-réactive ultra-sensible, hs-CRP (n=252), et des cytokines (n=283)) et des marqueurs de dommages dus au stress oxydant (8-isoprostanes 8-IsoPs (n=258) du condensat de l’air exhalé) avec les phénotypes de l’asthme.Elle a été réalisée dans le cadre de l'étude épidémiologique longitudinale Française des facteurs génétiques et environnementaux de l'asthme (EGEA).Les résultats ont montré que les niveaux de SP-D sériques étaient associés positivement avec la BPCO et des seuils des niveaux de SP-D chez ces patients ont été identifiés avec d'excellentes valeurs discriminantes. Dans EGEA, aucune association n'a été trouvée entre les niveaux de hs-CRP sériques et le contrôle de l’asthme. Des profils de cytokines sériques (identifiés par analyse en composante principale) avec des niveaux élevés d’interleukine(IL)-1Ra et d’IL-10 ont été associés avec moins de crises d'asthme et un risque plus faible d'un mauvais contrôle de l'asthme sept ans plus tard. Les résultats des analyses préliminaires sur les associations entre les niveaux de 8-IsoPs et les phénotypes de l'asthme sont également présentés.Globalement, ces résultats ont montré l'utilité d'étudier les marqueurs biologiques en lien avec la BPCO et l'asthme
Studying the biological markers in chronic obstructive pulmonary disease (COPD) and asthma, two chronic respiratory diseases affecting millions of individuals around the world, could improve their diagnosis, their treatment and their prevention.This thesis includes two parts. The first aimed to assess the association between a lung-specific biomarker, serum Surfactant Protein D (SP-D), and COPD, and to find cut-off points able to discriminate COPD patients from controls using SP-D levels. It was performed in a case-control study in Lebanon including COPD (n=90) and asthma patients (n=124) and controls (n=180). The second part aimed to assess the cross-sectional and longitudinal associations in adults for systemic inflammatory biomarkers (high sensitivity C reactive protein hs-CRP (n=252) and cytokines (n=283) as well as biomarkers of damage due to oxidative stress (8-Isoprostanes 8-IsoPs (n=258) from the exhaled breath condensate) and asthma outcomes.It was performed in the French longitudinal epidemiological study on the genetics and environmental factors of asthma (EGEA).Results showed that serum SP-D levels were positively associated with COPD and thresholds for SP-D levels in these patients were identified with excellent discriminant values. In EGEA, no association was found between serum hs-CRP levels and asthma control. Serum cytokine profiles (identified by principal component analysis) with high levels of interleukin (IL)-1Ra and IL-10 were associated with less asthma attacks and lower risk of poor asthma control in adults seven years later. The results of the preliminary analyses on the associations between the levels of 8-IsoPs and asthma outcomes are also presented.Overall, these results have shown the usefulness of studying the biological markers related to COPD and asthma
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Ammari, Wasem G. S. "Evaluation of novel tool to ensure asthma and COPD patients use the approved inhalation technique when they use an inhaler. Clinical pharmacy studies investigating the impact of novel inhalation technique training devices and spacers on the inspiratory characteristics, disease control and quality of life of patients when using their inhalers." Thesis, University of Bradford, 2010. http://hdl.handle.net/10454/4422.

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Many respiratory patients misuse their inhaler. Although training improves their inhaler technique, patients do forget the correct inhaler use with time. In the current work, three clinical studies investigated novel tools designed with feedback mechanisms to ensure patients use the correct inhalation method when using their inhaler. Research Ethics Committee approval was obtained and all the participants signed an informed consent form. In the first study, the recruited asthmatic children (n=17) and adults (n=39) had their metered dose inhaler (MDI) technique assessed. Those who attained the recommended inhalation flow rate (IFR) of < 90 l/min through their MDI formed the control group. Whilst those who had a poor MDI technique with an IFR ¿ 90 l/min were randomized into either the verbal counselling (VC) group; or the 2ToneTrainer (2TT) group that, in addition to the verbal training, received the 2ToneTrainer MDI technique training device equipped with an audible feedback mechanism of correct inhalation flow. All the participants were assessed on two occasions (6 weeks apart) for their inhalation flow rate, asthma control and quality of life. The study showed that the 2ToneTrainer tool was as efficient as verbal training in improving and maintaining the asthmatic patients¿ MDI technique, particularly using the recommended slow inhalation flow through the MDI. Although statistically insignificant, potential improvement in quality of life was demonstrated. The 2ToneTrainer tool has the advantage of being available to the patients all the time to use when they are in doubt of their MDI technique. In the second research study, the inhalation profiles of asthmatic children (n=58) and adults (n=63), and of COPD patients (n=63) were obtained when they inhaled through the novel Spiromax dry powder inhaler (DPI) which was connected to an electronic pressure change recorder. From these inspiratory profiles; the peak inhalation flow, inhalation volume and inhalation acceleration rate were determined. The variability (23% - 58%) found in these inhalation profile parameters among various patient groups would be expected in all DPIs. The effect of the inhalation acceleration rates and volumes on dose emission characteristics from DPIs should be investigated. Attention, though, should be paid to the patients¿ realistic inhalation profile parameters, rather than the recommended Pharmacopoeial optimal inhalation standard condition, when evaluating the in-vitro performance of DPIs. Finally, in preschool asthmatic children, the routine use of the current AeroChamber Plus spacer (n=9) was compared with that of a novel version; the AeroChamber Plus with Flow-Vu spacer (n=10) over a 12-week period. The Flow-Vu spacer has a visual feedback indicator confirming inhalation and tight mask-face seal. The study showed that the new AeroChamber Plus with Flow-Vu spacer provided the same asthma control as the AeroChamber Plus in preschool children and maintained the same asthma-related quality of life of their parents. However, the parents preferred the new Flow-Vu spacer because its visual feedback indicator of inhalation reassured them that their asthmatic children did take their inhaled medication sufficiently.
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Ammari, Wasem Ghazi Saleem. "Evaluation of novel tool to ensure asthma and COPD patients use the approved inhalation technique when they use an inhaler : clinical pharmacy studies investigating the impact of novel inhalation technique training devices and spacers on the inspiratory characteristics, disease control and quality of life of patients when using their inhalers." Thesis, University of Bradford, 2010. http://hdl.handle.net/10454/4422.

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Many respiratory patients misuse their inhaler. Although training improves their inhaler technique, patients do forget the correct inhaler use with time. In the current work, three clinical studies investigated novel tools designed with feedback mechanisms to ensure patients use the correct inhalation method when using their inhaler. Research Ethics Committee approval was obtained and all the participants signed an informed consent form. In the first study, the recruited asthmatic children (n=17) and adults (n=39) had their metered dose inhaler (MDI) technique assessed. Those who attained the recommended inhalation flow rate (IFR) of < 90 l/min through their MDI formed the control group. Whilst those who had a poor MDI technique with an IFR ≥ 90 l/min were randomized into either the verbal counselling (VC) group; or the 2ToneTrainer (2TT) group that, in addition to the verbal training, received the 2ToneTrainer MDI technique training device equipped with an audible feedback mechanism of correct inhalation flow. All the participants were assessed on two occasions (6 weeks apart) for their inhalation flow rate, asthma control and quality of life. The study showed that the 2ToneTrainer tool was as efficient as verbal training in improving and maintaining the asthmatic patients' MDI technique, particularly using the recommended slow inhalation flow through the MDI. Although statistically insignificant, potential improvement in quality of life was demonstrated. The 2ToneTrainer tool has the advantage of being available to the patients all the time to use when they are in doubt of their MDI technique. In the second research study, the inhalation profiles of asthmatic children (n=58) and adults (n=63), and of COPD patients (n=63) were obtained when they inhaled through the novel Spiromax dry powder inhaler (DPI) which was connected to an electronic pressure change recorder. From these inspiratory profiles; the peak inhalation flow, inhalation volume and inhalation acceleration rate were determined. The variability (23%-58%) found in these inhalation profile parameters among various patient groups would be expected in all DPIs. The effect of the inhalation acceleration rates and volumes on dose emission characteristics from DPIs should be investigated. Attention, though, should be paid to the patients' realistic inhalation profile parameters, rather than the recommended Pharmacopoeial optimal inhalation standard condition, when evaluating the in-vitro performance of DPIs. Finally, in preschool asthmatic children, the routine use of the current AeroChamber Plus spacer (n=9) was compared with that of a novel version; the AeroChamber Plus with Flow-Vu spacer (n=10) over a 12-week period. The Flow-Vu spacer has a visual feedback indicator confirming inhalation and tight mask-face seal. The study showed that the new AeroChamber Plus with Flow-Vu spacer provided the same asthma control as the AeroChamber Plus in preschool children and maintained the same asthma-related quality of life of their parents. However, the parents preferred the new Flow-Vu spacer because its visual feedback indicator of inhalation reassured them that their asthmatic children did take their inhaled medication sufficiently.
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Cáceres, Rivera Diana Isabel 1984. "Innovaciones en el entrenamiento de músculos respiratorios en pacientes con enfermedad pulmonar obstructiva crónica (EPOC) : Diseño de una válvula dual digital con incentivos visual y sonoro, diseño de un software de registro y control del entrenamiento, y evaluación del impacto de un nuevo esquema de entrenamiento corto de alta intensidad." Doctoral thesis, Universitat Pompeu Fabra, 2017. http://hdl.handle.net/10803/482047.

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INTRODUCTION: Respiratory muscle weakness and fatigue are related to clinical deterioration in patients with Chronic Obstructive Pulmonary Disease (COPD). Respiratory muscle training (RMT) is a key therapeutic strategy in these patients. It is necessary therefore to increase its dissemination on a large scale, improve patient´s adherence and optimize the control of the implementation of training. The aim of this project was to design a RMT device including light and sound incentives, digital registration application and analysis of the training sessions, and studying the effectiveness of a new shortened RMT scheme of high intensity that could provide added value to enhance the implementation of training in patients with COPD. METHODS: From an operational point of view, researches were organized into three packages of complementary work focused on the design of a new portable dual valve with electronic lighting and auditory incentives components. The conceptualization and design of software to analyze the performance and individual continuous use of the valve, and the evaluation of the feasibility, safety and efficacy of a shortened schedule of respiratory muscle training in adult patients with COPD were realized. RESULTS: The invention of an integrated dual valve system (inspiratory and expiratory) and its calibration software, adaptation, recording, individual analysis for respiratory muscle training was developed. Interventions allowed showing that inspiratory and expiratory muscle training added value to the general physical training with a response in one or more functional variables in 86% of patients. In fact, the most important occurred in those receiving respiratory training together with high overall intensity more inspiratory and / or expiratory. Patients who perform general training + Shortened RMT of high intensity obtained significant improvements values in PImax, PEmax, Watt, Watt/VO2peak y 6mWT. (p<0,05). CONCLUSIONS: The invention of a new valve of respiratory muscle training with lighting and sound incentive, the design of an innovative software related to its use, and the identification of the efficacy and safety of a new shortened scheme of respiratory muscle training (supervised and self-administered) bring technological and services innovation with potential clinical relevance regarding non-pharmacological management of patients with COPD. These strategies could increase the spread of respiratory muscle training in both hospital and outpatient settings.
INTRODUCCIÓN: La debilidad y fatiga de los músculos respiratorios se relacionan con el deterioro clínico (síntomas, signos) y funcional en pacientes con Enfermedad Pulmonar Obstructiva Crónica (EPOC). Dado que el entrenamiento muscular respiratorio (EMR) constituye una estrategia terapéutica fundamental para estos pacientes, es necesario aumentar su difusión a gran escala, mejorar la adherencia de los pacientes, y optimizar el control de la ejecución del entrenamiento. El objetivo principal de este proyecto fue diseñar un dispositivo de EMR con incentivo luminoso y sonoro, aplicación digital de registro y análisis de las sesiones de entrenamiento, y a la vez, estudiar la efectividad de un esquema de EMR de alta intensidad y corta duración que, en conjunto, ofrecieran un valor añadido para mejorar la aplicación del entrenamiento en pacientes con EPOC. MÉTODOS: Desde el punto de vista operativo, las investigaciones se organizaron en tres paquetes de trabajo complementarios dirigidas a: 1) diseño de una nueva válvula dual portátil con componentes electrónicos de incentivo lumínico y auditivo, 2) la conceptualización y diseño de un software de análisis del funcionamiento y uso individual y continuado de la válvula, y 3) la evaluación de la eficacia de un esquema acortado de EMR en pacientes con EPOC estable mediante ensayo clínico aleatorizado. RESULTADOS: Se realizó la invención y desarrollo de un sistema integrado de una válvula dual (inspiratoria y espiratoria) y su software de calibración, adecuación, registro y análisis individual para el EMR. Las intervenciones permitieron demostrar que el entrenamiento muscular inspiratorio y espiratorio aporta valor añadido al entrenamiento físico general, con una respuesta ante el entrenamiento en una o más variables funcionales en el 86% de los pacientes. Los pacientes que realizaron entrenamiento general + EMR de corta duración y alta intensidad, obtuvieron mejorías significativas en los valores de PImax, PEmax, Watt, Watt/VO2peak y 6mWT. (p<0,05). CONCLUSIONES: La invención de una nueva válvula de EMR con incentivador lumínico y sonoro, el diseño de un innovador software relacionado con su uso, así como la identificación de la eficacia y seguridad un nuevo esquema de EMR de alta intensidad y corta duración, supervisado y autoadministrado, aportan innovación tecnológica y terapéutica con relevancia clínica potencial referente al manejo no-farmacológico de los pacientes con EPOC. Es importante destacar que estas estrategias pueden aumentar la difusión del EMR tanto en entornos hospitalarios como ambulatorios.
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Neubert, Miranda J., Elizabeth A. Dahlmann, Andrew Ambrose, and Michael D. L. Johnson. "Copper Chaperone CupA and Zinc Control CopY Regulation of the Pneumococcal cop Operon." AMER SOC MICROBIOLOGY, 2017. http://hdl.handle.net/10150/626457.

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Any metal in excess can be toxic; therefore, metal homeostasis is critical to bacterial survival. Bacteria have developed specialized metal import and export systems for this purpose. For broadly toxic metals such as copper, bacteria have evolved only export systems. The copper export system (cop operon) usually consists of the operon repressor, the copper chaperone, and the copper exporter. In Streptococcus pneumoniae, the causative agent of pneumonia, otitis media, sepsis, and meningitis, little is known about operon regulation. This is partly due to the S. pneumoniae repressor, CopY, and copper chaperone, CupA, sharing limited homology to proteins of putative related function and confirmed established systems. In this study, we examined CopY metal crosstalk, CopY interactions with CupA, and how CupA can control the oxidation state of copper. We found that CopY bound zinc and increased the DNA-binding affinity of CopY by roughly an order of magnitude over that of the apo form of CopY. Once copper displaced zinc in CopY, resulting in operon activation, CupA chelated copper from CopY. After copper was acquired from CopY or other sources, if needed, CupA facilitated the reduction of Cu2+ to Cu1+, which is the exported copper state. Taken together, these data show novel mechanisms for copper processing in S. pneumoniae. IMPORTANCE As mechanisms of copper toxicity are emerging, bacterial processing of intracellular copper, specifically inside Streptococcus pneumoniae, remains unclear. In this study, we investigated two proteins encoded by the copper export operon: the repressor, CopY, and the copper chaperone, CupA. Zinc suppressed transcription of the copper export operon by increasing the affinity of CopY for DNA. Furthermore, CupA was able to chelate copper from CopY not bound to DNA and reduce it from Cu2+ to Cu1+. This reduced copper state is essential for bacterial copper export via CopA. In view of the fact that innate immune cells use copper to kill pathogenic bacteria, understanding the mechanisms of copper export could expose new small-molecule therapeutic targets that could work synergistically with copper against pathogenic bacteria.
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Duckworth, Kevin A. "La dépression dans la maladie pulmonaire obstructive chronique prédit-elle la fréquentation et la conformité à l'exercice pendant la rééducation respiratoire, et le niveau d'exercice maintenu 9 mois plus tard?" Thèse, Université de Sherbrooke, 2017. http://hdl.handle.net/11143/11256.

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La maladie pulmonaire obstructive chronique (MPOC) est une maladie respiratoire irréversible, évolutive et très fréquente qui fait peser un lourd fardeau sur le système de santé, les patients et leurs proches. La réadaptation pulmonaire (RP) est efficace pour réduire la dyspnée et l’utilisation des ressources en soins de santé et pour améliorer la capacité physique et la qualité de vie des patients. L’entraînement physique est la pierre angulaire de la RP, mais elle n’est bénéfique que si les patients 1) assistent aux séances d’exercice, 2) se conforment à l'intensité des exercices prescrits et 3) maintiennent l'exercice physique régulier après la RP. La dépression comorbide est disproportionnée dans la MPOC et s’est révélée être un facteur prédictif de « mauvaise » fréquentation de la RP, et d'abandon de la pratique physique régulière après le programme. À notre connaissance, aucune étude ne s'est intéressée aux prédicteurs de conformité à l'intensité d'exercice prescrit pendant la RP et seules quelques études ont explorées les facteurs associés au maintien de l'exercice après la RP. L’objectif principal de cette étude consistait à examiner dans quelle mesure les symptômes dépressifs à l'entrée de la RP permettent de prédire 1) la présence aux séances de RP, 2) le respect de l'intensité (conformité) des exercices d’endurance prescrits pendant la RP, et 3) le niveau d’exercice physique maintenu 9 mois après la RP. Un deuxième objectif consistait à explorer d'autres variables susceptibles d'être associées à ces paramètres. Trente-six patients (64 % de femmes) atteints de la MPOC stable, modérée à sévère, ont été inscrits à un programme de RP de 12 semaines comportant 36 séances d’exercice physique supervisé. À l’entrée du RP les patients ont rempli l’Inventaire de Dépression de Beck (BDI-II, le prédicteur principal) et le formulaire C de l’Échelle du locus de contrôle sur la santé (LCS), et ont subi des tests de fonction pulmonaire et une épreuve d’effort progressif à vélo (pour déterminer l'intensité de l'exercice pour la RP). Ensuite, ils ont été répartis de façon aléatoire dans trois groupes à intensité d’exercice différente. La fréquentation de la RP était définie comme le pourcentage de séances suivies; la conformité, comme la durée d’entraînement pratiquée à la fréquence cardiaque cible; et le maintien de l'exercice physique régulier comme le niveau d’exercice fait au cours d’une semaine 9 mois après la RP (enregistré dans un journal d’activité physique et calculé en équivalents métaboliques de l’effort [MET] minutes ). La médiane (écart interquartile ou IQR) du score au BDI-II était de 8,5 points (6-13), la médiane (IQR) du taux de la fréquentation aux séances était de 83% (67-94), la médiane du taux de compliance à l’intensité d'exercice était de 94% (71-99), et la médiane du nombre de minutes MET après la RP était de 706 (445-1146). Les analyses de régression linéaire ne montrent pas de relation entre les symptômes dépressifs pré-RP et la fréquentation des séances de la RP (ß = 0,12; p = 0,478). Par-contre, ils étaient associés à la conformité à l'intensité de l’exercice physique pendant la RP (ß = -0,40; p = 0,047), et à la poursuite de la pratique d’un exercice physique régulier après la RP (ß = -0,50; p = 0,004). Les analyses étaient ajustées pour des covariables prédéfinies. Les analyses exploratoires ont révélé que certaines variables supplémentaires (y compris LCS) étaient associées aux issues mesurées. Les résultats de cette étude montrent que même les niveaux de dépression sous-cliniques pourraient jouer un rôle important dans la compliance aux programme de réentraînement, et au maintien d’un style de vie actif après la période de réadaptation. Cela a des implications pour améliorer le dépistage des « mauvais » résultats dans la RP et pour l'élaboration d'interventions ciblées pour améliorer les bénéfices pour la santé découlant de la réadaptation pour la MPOC.
Abstract : Chronic obstructive pulmonary disease (COPD) is an irreversible, progressive, and highly prevalent respiratory illness that poses a great burden on the healthcare system, patients, and their families. Pulmonary rehabilitation (PR) is effective in reducing dyspnea and health care resource utilization, and increasing exercise capacity and quality of life. Exercise training is the cornerstone of PR but is only beneficial if patients 1) attend sessions, 2) comply with the prescribed exercise regimen, and 3) maintain regular exercise after supervised PR ends. Comorbid depression is disproportionately high in COPD and has been found to predict poor attendance at PR and low levels of exercise maintained afterwards. To our knowledge, no study has investigated predictors of exercise compliance during PR, and only a few studies have examined predictors of exercise maintenance post PR. The primary objective of this study was to examine how much baseline depressive symptomatology can predict 1) PR attendance, 2) PR exercise compliance, and 3) levels of exercise maintained at 9-months post PR. A secondary, exploratory objective was to identify additional variables that might also have significant associations with these outcomes. Thirty-six patients (64% female) with stable COPD were enrolled in a 12-week 36-session supervised exercise intervention in the context of a PR program. Patients underwent evaluations at entry to PR which included the Beck Depression Inventory (BDI-II, the main predictor), the Multidimensional Health Locus of Control (HLC) Scale Form-C, pulmonary function tests, and an incremental cycling test (to determine the exercise intensity prescription). Patients were randomized to one of three groups of varying exercise intensity. Attendance was defined as the percent of total sessions attended, compliance as the percent of endurance training time exercising at a prescribed target heart rate, and post-PR exercise as the total exercise performed over a 7-day period recorded in a physical activity diary and calculated as metabolic equivalent of task (MET) minutes. Median (IQR) baseline BDI-II was 8.5 (6-13), median (IQR) percent attendance was 83 (67-94), median (IQR) percent exercise compliance was 94 (71-99), and median (IQR) exercise MET-minutes post PR was 706 (445-1146). In multiple regression analyses, baseline depressive symptomatology did not emerge as a significant independent predictor of PR attendance (ß = .12, p = .478), but was a significant predictor of PR exercise compliance (ß = -.40, p = .047), and of exercise maintained post PR (ß = -.50, p = .004), with adjustment for a-priori defined covariates. Secondary exploratory analyses revealed that certain additional variables (including HLC) had associations with particular outcomes. The findings suggest that even subclinical levels of depression can predict PR exercise compliance and post-PR exercise levels. This has implications for improving screening for, and understanding of, poor outcomes in PR and for developing targeted interventions to optimize the health benefits that can be derived during and after PR for COPD.
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Books on the topic "COPD control"

1

Pittner, John, and Marwan A. Simaan. Tandem Cold Metal Rolling Mill Control. London: Springer London, 2011. http://dx.doi.org/10.1007/978-0-85729-067-0.

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Rogov, S. M. Arms control after the end of the Cold War. Alexandria, Va. (4401 Ford Ave., Alexandria 22302-1498): Center for Naval Analyses, 1997.

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Brown, Paul Curtis. Naval arms control: A post-Cold War reappraisal. Monterey, Calif: Naval Postgraduate School, 1991.

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Kennan, George Frost. After the cold war. Washington, D.C: American Committee on U.S.-Soviet Relations, 1989.

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Control of the cold chain for quick-frozen foods handbook. Paris: The Institute, 1999.

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Latter, Richard. Defence conversion and conventional arms control after the cold war. London: HMSO, 1992.

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Pittner, John. Tandem cold metal rolling mill control: Using practical advanced methods. London: Springer, 2011.

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1945-, Walters Timothy Robert, ed. From my cold dead fingers: Why America needs guns. Safford, Ariz: Rawhide Western Publishing, 1994.

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IBRO Symposium (1991 Paris, France). Muscle afferents and spinal control of movement. Oxford: Pergamon Press, 1992.

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Stepping back: Nuclear arms control and the end of the Cold War. Westport, Conn: Praeger, 1994.

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Book chapters on the topic "COPD control"

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Gianotti, A., P. Moscatelli, and N. Franconieri. "Chronic Obstructive Pulmonary Disorders (COPD) and Sleep." In Control of Breathing During Sleep and Anesthesia, 47. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4757-9850-0_8.

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Gözükirmizi, E., N. Yildirim, H. Kaynak, S. Madazlioğlu, H. Denktas, and F. Yenel. "Polysomnographic Findings in Patients with Chronic Obstructive Pulmonary Disease (COPD)." In Control of Breathing During Sleep and Anesthesia, 49–53. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4757-9850-0_9.

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Folgering, H., P. Vos, and C. van Herwaarden. "Control of Breathing in Copd-Patients With Sleep Hypopnea; Effects of Acetazolamide and Chlormadinone Acetate." In Control of Breathing and Its Modeling Perspective, 331–35. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4757-9847-0_58.

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Kroumov, Valeri, Katsuki Yoshino, and Sachio Tsukamoto. "Performances of Different Control Laws for Automatic Oxygen Supply for Copd Patients." In Advances in Experimental Medicine and Biology, 85–91. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4757-9077-1_15.

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Nardi, Aaron, Dennis Helfritch, Ozan Cagatay Ozdemir, and Victor Kenneth Champagne. "Process Control." In Practical Cold Spray, 265–84. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-70056-0_7.

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Weik, Martin H. "multiple-copy control." In Computer Science and Communications Dictionary, 1059. Boston, MA: Springer US, 2000. http://dx.doi.org/10.1007/1-4020-0613-6_11947.

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Roe, Emery. "Control, manage or cope?" In The Politics of Uncertainty, 73–84. Abingdon, Oxon; New York, NY: Routledge, 2020. | Series: Pathways to sustainability: Routledge, 2020. http://dx.doi.org/10.4324/9781003023845-5.

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Todd, Andrew J. "Plasticity of Inhibition in the Spinal Cord." In Pain Control, 171–90. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-46450-2_9.

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Matsumoto, Naoyuki. "Biological Control of Snow Mold." In Plant Cold Hardiness, 343–50. Boston, MA: Springer US, 1997. http://dx.doi.org/10.1007/978-1-4899-0277-1_32.

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Sorkin, Linda S. "Modulation of Peripheral Inflammation by the Spinal Cord." In Pain Control, 191–206. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-46450-2_10.

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Conference papers on the topic "COPD control"

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Vargas Centanaro, Gianna, Myriam Calle Rubio, Elena Forcen Vicente De Vera, Guillermo Rubio De La Garza, Ana Palomar Santamaria, Fernando Pelaez Castro, Soha Smaili, Andrea Albuja, and Juan Luis Rodriguez Hermosa. "Clinical control of COPD according to outpatient respiratory clinics: general versus specialized COPD." In ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa2510.

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Xiaobo, Yang, Chen Chuxiang, Wang Zhiwan, and Dai Yaozong. "Community detection in TCM network of COPD." In 2017 36th Chinese Control Conference (CCC). IEEE, 2017. http://dx.doi.org/10.23919/chicc.2017.8027546.

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Ionescu, Clara M., and Robin De Keyser. "Flow controlled artificial ventilation of a COPD patient." In 2009 European Control Conference (ECC). IEEE, 2009. http://dx.doi.org/10.23919/ecc.2009.7074777.

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Zakarya, Razia, Hui Chen, Corey-Anke Brandsma, Ian M. Adcock, and Brian G. G. Oliver. "Epigenetic control of TGFβ induced fibrosis in COPD." In ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.pa961.

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Nadigel, Jessica, Carolyn J. Baglole, David H. Eidelman, and Qutayba Hamid. "Differential Cytokine Production Between COPD And Control Epithelial Cells." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4562.

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Miravitlles, Marc, Juan Jose Soler-Cataluna, Bernardino Alcazar, Anjan Nibber, Alison Chisholm, Joan B. Soriano, and David Price. "Validation of the COPD control concept: A UK pilot." In ERS International Congress 2016 abstracts. European Respiratory Society, 2016. http://dx.doi.org/10.1183/13993003.congress-2016.pa1127.

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Tanabe, N., S. Sato, T. Oguma, H. Shima, T. Kubo, S. Kozawa, K. Tanimura, et al. "Comparisons of Airway Dimensions Between COPD, Asthma-COPD Overlap, and Control Smokers Using Ultra-High-Resolution CT." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2351.

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Cleutjens, Fiona, Frits Franssen, Martijn Spruit, Lowie Vanfleteren, Candy Gijsen, Jeanette Dijkstra, Rudolf Ponds, Emiel Wouters, and Daisy Janssen. "Domain-specific cognitive impairment in patients with COPD and control subjects." In ERS International Congress 2016 abstracts. European Respiratory Society, 2016. http://dx.doi.org/10.1183/13993003.congress-2016.pa3742.

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Öztürk, Murat, Ipek Özmen, Mine Gülden Polat, Elif Yıldırım, and Meral Karakış. "Effect of pulmonary rehabilitation on balance control in patients with COPD." In ERS International Congress 2018 abstracts. European Respiratory Society, 2018. http://dx.doi.org/10.1183/13993003.congress-2018.pa838.

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Yao, Shijun, Liang Zhang, Chuxiang Chen, Zhiwan Wang, and JianJing Shen. "Research on diagnostic models of COPD syndromes in TCM based on BP neural network." In 2014 33rd Chinese Control Conference (CCC). IEEE, 2014. http://dx.doi.org/10.1109/chicc.2014.6895798.

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Reports on the topic "COPD control"

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Mabuchi, Hideo. Coherent-feedback Quantum Control with Cold Atomic Spins. Fort Belvoir, VA: Defense Technical Information Center, August 2012. http://dx.doi.org/10.21236/ada572921.

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Zeilenga, K. The Lightweight Directory Access Protocol (LDAP) Don't Use Copy Control. RFC Editor, March 2011. http://dx.doi.org/10.17487/rfc6171.

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Stein, Peter C., Robert P. Hilton, George Quester, and Dennis F. DeRiggi. Naval Power and Naval Arms Control During the Cold War. Fort Belvoir, VA: Defense Technical Information Center, July 1992. http://dx.doi.org/10.21236/ada278934.

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Yang, Xinwei, Huan Tu, and Xiali Xue. The improvement of the Lower Limb exoskeletons on the gait of patients with spinal cord injury: A protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, August 2021. http://dx.doi.org/10.37766/inplasy2021.8.0095.

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Review question / Objective: The purpose of this systematic review and meta-analysis was to determine the efficacy of lower extremity exoskeletons in improving gait function in patients with spinal cord injury, compared with placebo or other treatments. Condition being studied: Spinal Cord Injury (SCI) is a severely disabling disease. In the process of SCI rehabilitation treatment, improving patients' walking ability, improving their self-care ability, and enhancing patients' self-esteem is an important aspect of their return to society, which can also reduce the cost of patients, so the rehabilitation of lower limbs is very important. The lower extremity exoskeleton robot is a bionic robot designed according to the principles of robotics, mechanism, bionics, control theory, communication technology, and information processing technology, which can be worn on the lower extremity of the human body and complete specific tasks under the user's control. The purpose of this study was to evaluate the effect of the lower extremity exoskeleton on the improvement of gait function in patients with spinal cord injury.
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Kline, Adam, and Tim Hwang. From Cold War Sanctions to Weaponized Interdependence: An Annotated Bibliography on Competition and Control over Emerging Technologies. Center for Security and Emerging Technology, September 2021. http://dx.doi.org/10.51593/20210027.

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As U.S. policymakers grapple with the need to control international technology flows, this annotated bibliography distills key lessons and surveys 50 years of scholarship, government documents, and commentary. The resources it presents are at the intersection of international economics and technology and span from the Cold War to the current challenges surrounding U.S.-China relations.
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White, Elmer G. Cold War Arms Control Motivations and Techniques - A Guide for the Future? Fort Belvoir, VA: Defense Technical Information Center, January 1996. http://dx.doi.org/10.21236/ada326946.

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WHITEHURST, R. Cold Vacuum Drying (CVD) Facility Safety Class Instrumentation & Control System Design Description. Office of Scientific and Technical Information (OSTI), December 1999. http://dx.doi.org/10.2172/798859.

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Garcia-Martin, M., and G. Camarillo. Extensible Markup Language (XML) Format Extension for Representing Copy Control Attributes in Resource Lists. RFC Editor, October 2008. http://dx.doi.org/10.17487/rfc5364.

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Wunderlich, Carmen, Harald Müller, and Una Jakob. WMD Compliance and Enforcement in a Changing Global Context. The United Nations Institute for Disarmament Research, May 2020. http://dx.doi.org/10.37559/wmd/21/wmdce02.

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The regimes for the control of weapons of mass destruction (WMD) are essential ingredients of the global order. Yet this order is currently in transition: the bipolarity of the Cold War has given way to a more complex, multipolar world order characterized by conflicts of interest and great power competition rather than cooperative security. This competition brings with it rising strategic uncertainties which endanger stability and have far reaching implications for WMD-related agreements. To better understand the implications of this changing global context for WMD arms control and disarmament measures this report looks at the past, present and future prospects for WMD-related treaties. The report begins by outlining four broad yet interlinked approaches to arms control and disarmament before considering how these have been applied to chemical, biological and nuclear weapons in the past and how these measures could be applied in the future.
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ANGLESEY, M. O. System Configuration Management Implementation Procedure for the Cold Vacuum Drying Facility Monitoring and Control System. Office of Scientific and Technical Information (OSTI), October 2000. http://dx.doi.org/10.2172/805643.

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