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Dissertations / Theses on the topic 'Copper catalyzed synthesis'

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Published: 6 September 2023

Last updated: 7 September 2023

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1

Black, Daniel. "Imines in copper-catalyzed cross-coupling reactions." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=102960.

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The purpose of this study was to develop new catalytic methods to mediate carbon-carbon bond forming reactions with imines under mild conditions and in a general manner. We found that copper catalysts were compatible in cross-coupling of a range of mild organometallic reagents, providing simple, efficient routes to alpha-substituted amides and amines.<br>Chapter 2 of this thesis describes a new copper-catalyzed multicomponent synthesis of alpha-substituted amides. This reaction was developed based upon previous work in this laboratory, which showed that palladium catalysts were competent in St

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2

Wong, Zackary L. (Zackary Leland). "Copper-catalyzed enantioselective stereodivergent synthesis of amino alcohols." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/103506.

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Thesis: S.M., Massachusetts Institute of Technology, Department of Chemistry, 2016.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 46-50 (first group)).<br>Different stereoisomers of bioactive molecules can have distinct activities in biological systems. For this reason, it is routine procedure in the drug discovery and development process to prepare the full matrix of possible stereoisomers of drug candidates for biological evaluation and to determine the stereochemical purity of these molecules. Despite many recent advances in asymmetric synthesis, the

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3

Huang, Zeyu. "Synthesis of Multifunctional Organoboron Compounds by Copper-Catalyzed Enantioselective Reactions:." Thesis, Boston College, 2017. http://hdl.handle.net/2345/bc-ir:107346.

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Thesis advisor: Amir H. Hoveyda<br>Chapter 1. We have developed a catalytic method for enantio- and SN2’-selective allylic substitution of commercially available diborylmethane to trisubstituted allylic phosphates (pin = pinacolato). The transformations are catalyzed by NHC–Cu complexes (NHC = N-heterocyclic carbene). Products bearing quaternary stereogenic carbon centers are obtained in up to 86% yield (after oxidation), >98:2 SN2’/SN2 selectivity and 95:5 enantiomeric ratio (e.r.). Chapter 2. We have developed a facile multicomponent catalytic process that begins with a chemo- and site-se

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4

Takeda, Momotaro. "Copper-Catalyzed Asymmetric Allylic Substitution with Organo- and Silylboronates." 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/188504.

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5

Meng, Fanke. "Design of Copper-Catalyzed Multicomponent Reactions and Applications to Natural Product Synthesis." Thesis, Boston College, 2015. http://hdl.handle.net/2345/bc-ir:104876.

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Thesis advisor: Amir H. Hoveyda<br>Chapter 1. Ligand-Controlled Site-Selective NHC–Cu-Catalyzed Protoboration of Monosubstituted Allenes. Site-selective proto–boryl additions to monosubstituted allenes promoted by NHC–Cu complexes are disclosed. Synthetically useful 1,1-disubstituted and Z-trisubstituted alkenylboron compounds are afforded in high efficiency (71%–92% yield) and site selectivity (88% to >98%) through proper choice of NHC ligands. Mechanistic study with the assistance of DFT calculations indicates that protonation of 2-boron-substituted allylcopper complex occurs through six-

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6

Dong, Wanrong [Verfasser]. "Rhodium-catalyzed direct C-H functionalizations of sulfoximines and copper-catalyzed enantioselective synthesis of dihydropyrazoles / Wanrong Dong." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2014. http://d-nb.info/1057036587/34.

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7

McIntosh, Melissa Clark Timothy B. "Copper-catalyzed diboration of ketones : facile synthesis of tertiary a-Hydroxyboronate esters /." Online version, 2010. http://content.wwu.edu/cdm4/item_viewer.php?CISOROOT=/theses&CISOPTR=336&CISOBOX=1&REC=11.

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8

Ou, Jun, and 欧军. "Asymmetric reactions induced by phase-tagged phosphoric acid organocatalysts and copper hydride-catalyzed reductions of unsaturatedthioesters." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47849708.

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Two syntheses of non-cross-linked polystyrene-supported TADDOL-based phosphoric acid organocatalyst have been developed. The optimal polymer-supported catalyst 2.29d exhibited comparable catalytic activity to its small molecule counterpart in asymmetric Mannich-type reactions, and the syntheses of several chiral β-amino esters were demonstrated using 2.29d as catalyst. However, when this TADDOL-based phosphoric acid was immobilized on a polystyrene cross-linked with 1,4-bis(4-vinylphenoxy)butane, ie. JandaJelTM, the catalytic activity diminished in the first recycling and reuse of the

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9

Ota, Yusuke. "Synthesis of Nitrogen-Containing Polycyclic Compounds through Copper-Catalyzed Multi-Component Reaction." 京都大学 (Kyoto University), 2010. http://hdl.handle.net/2433/120509.

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10

Lonca, Geoffroy. "Development of new reactions of organic synthesis catalyzed by gold and copper." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLX057/document.

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Cette thèse décrit le développement de nouvelles méthodes de catalyse à l’or et au cuivre pour la synthèse de composés hétérocycliques et de produits trifluorométhylés.Dans un premier temps, une synthèse d’allènes trifluorométhylés par catalyse à l’or a été développée, dont l’étape clé est un transfert d’hydrure 1,5. Cette méthode donne accès de manière efficace et sélective à une large gamme d’allène perfluoroalkylés dont le potentiel synthétique a également été démontré.Le pouvoir catalytique de l’or a alors été utilisé dans une synthèse de 2H-1,3-oxazines reposant sur une cyclisation de typ

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11

Norinder, Jakob. "Asymmetric Synthesis and Mechanistic Studies on Copper(I)-Catalyzed Substitution of Allylic Substrates." Doctoral thesis, Stockholm : Department of Organic Chemistry, Stockholm University, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1031.

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12

Wu, Fan. "Iodide-Catalyzed Alkene Oxyamination Reactions for the Synthesis of Nitrogen-Containing Heterocycles." University of Toledo / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1576248441561743.

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13

Barabe, Francis. "Gold(I)-Catalyzed Synthesis of Polycyclic Frameworks Related to Terpenes: Selective Divergent Synthesis of Fused Carbocycles." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/29055.

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Gold catalysis has become an important tool to achieve highly chemoselective p-acid activation. Exceptional reactivity and selectivity are often encountered under mild reaction conditions. These properties have made gold(I) complexes suitable catalysts for tremendous applications in the total synthesis of natural products. The first chapter will highlight a number of total syntheses using gold catalysis as a key step. The second chapter will cover our application of the gold(I)-catalyzed 6-endo-dig carbocyclization for the synthesis of bridgehead-substituted scaffolds and its use toward the

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14

Brown, Michael Kevin. "CU-catalyzed enantioselective conjugate addition of organometal reagents to unsaturated carbonyls : an enantioselective total synthesis of clavirolide C." Thesis, Boston College, 2008. http://hdl.handle.net/2345/964.

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15

Li, Jihui. "Copper-Catalyzed Domino C-N Bond Formation for Synthesis of N-Containing Compounds (Benzimidazoles, Imidazoles, and Guanidines) - Approach toward Total Synthesis of Natural Product Raputindoles." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA112130.

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Cette thèse est constituée de trois parties : 1) Le contexte bibliographique, 2) le développement de réactions domino cupro-catalysées et 3) une approche vers la synthèse totale des raputindoles.La première partie introduit d’abord le concept de réactions domino ainsi que leurs applications, puis les réactions catalysées par du cuivre permettant de former des liaisons C-N sont passées en revue en incluant les couplages de Ullmann, Goldberg et de Chan-Lam, les séquences d’activation oxydante de liaisons C-H/formation de liaison C-N, l’insertion de nitrènes et l’hydroamination de liaisons C-C mu

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16

Gilligan, Ruth Elaine. "Copper-catalyzed C-H arylation : development of new methodology and its application to the total synthesis of staurosporinone." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607788.

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17

Husmann, Ralph [Verfasser]. "Synthesis and application of silylated pyrrolidines enantioselective organocatalytic synthesis of a-trifluoromethyl a-amino acid derivatives and copper-catalyzed multicomponent reactions / Ralph Husmann." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2011. http://d-nb.info/1018190465/34.

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18

Chatalova, Sazepin Claire. "Radical methods for the synthesis of fluoroalkanes and fluoromethyl aryl ethers and copper-catalyzed three-component carboetherification of alkenes." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/55907.

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Fluorinated molecules have become popular compounds among pharmaceuticals. The introduction of fluorine atoms on bioactive compounds has indeed the potential to improve their biophysical properties. Given the utility of fluorinated substituents on pharmaceuticals, fluorine chemistry has become an area of intensive research. Despite the progress made in selective fluorination, however, radical fluorination has been limited notably due to the paucity of atomic fluorine sources. In this thesis, the uncovering of new atomic fluorine sources and the development of new radical fluorination methods w

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19

HU, JIEYU. "COPPER(I) CATALYZED EXO-SELECTIVE [CN+C+CC] 1,3-DIPOLAR CYCLOADDITIONS and STUDIES TOWARDS THE TOTAL SYNTHESIS OF KAITOCEPHALIN." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1269965489.

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20

Andrella, Nicholas Orlando. "Synthesis of Organo-fluorine Compounds by Metal Complex-mediated and -Catalyzed Transformations of Fluoro-alkenes and Fluoro-arenes." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39509.

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The prevalence of fluorine in natural products is scarce. There are but a handful of compounds that have been discovered to date. This could be largely attributable to the occurrence of fluorine in nature as fluoride (F-). — One might recognize such nomenclature from the ingredients list on a toothpaste tube — In fact, naturally occurring fluoride is most commonly found as fluorite (CaF2) or cryolite (Na3AlF6). As such, the introduction of fluorine via biological pathways has been limited to use of aqueous F- (a very poor nucleophile). This fact — coupled with its naturally low concentration i

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21

Komati, Rajesh. "Cu (II) Catalyzed Gateways In The Synthesis of Acridine Derivatives and Their Biological Evaluation as Anti-Cancer Drugs." ScholarWorks@UNO, 2014. http://scholarworks.uno.edu/td/1818.

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Telomeres are nucleoprotein complexes found at the ends of linear eukaryotic chromosomes. Telomeres consist of a short sequence of repetitive double stranded DNA, TTAGGG repeats in humans (and all mammals), and a complex of 6 proteins, termed the shelterin complex. The length of the telomeres varies greatly between species, from approximately 300 base pairs in yeast to many 10-15 kilo bases in humans, because of the end replication problem this length get shorten with each cell division and ultimately leads to cell death. However the immortal eukaryotic cells and some transformed human cells o

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22

Decan, Matthew. "The Copper(I)-catalyzed Azide–Alkyne Cycloaddition: A Modular Approach to Synthesis and Single-Molecule Spectroscopy Investigation into Heterogeneous Catalysis." Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31882.

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Click chemistry is a molecular synthesis strategy based on reliable, highly selective reactions with thermodynamic driving forces typically in excess of 20 kcal mol-1. The 1,3-dipolar cycloaddition of azides and alkynes developed by Rolf Huisgen saw dramatic rate acceleration using Cu(I) as a catalyst in 2002 reports by Barry Sharpless and Morten Meldal enabling its click chemistry eligibility. Since these seminal reports, the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) has become the quintessential click reaction finding diverse utility. The popularity of the CuAAC has naturally l

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23

Lee, Elaine C. "Improved synthesis and application of planar-chiral nucleophilic catalysts in asymmetric reactions and copper-catalyzed enantioselective N-H insertion reactions." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/39741.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2007.<br>Vita.<br>Includes bibliographical references.<br>The development of an improved synthesis of nucleophilic planar-chiral catalysts is described in Chapter 1. This route is amenable to scale-up and preparative chiral HPLC is unnecessary to resolve the racemic catalysts. Using planar-chiral catalysts, two synthetic methodology projects have been developed: Chapter 2 describes the first asymmetric synthesis of trans P-lactams, and Chapter 3 describes the asymmetric synthesis of tertiary a-chloroesters. In the chap

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24

Jones, Carrie Preston. "Development of a copper-catalyzed amidation-base-promoted cyclization sequence for the synthesis of 2-aryl- and 2-vinyl1-4 quinolones." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/41771.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2007.<br>Vita.<br>Includes bibliographical references (p. 45-48).<br>A direct two-step method for the preparation of 2-aryl- and 2-vinyl-4-quinolones that utilizes a copper-catalyzed amidation of ortho-halophenones followed by a base-promoted Camps cyclization of the resulting N-(2-keto-aryl)amides is described. With Cul, a diamine ligand, and base as the catalyst system, the amidation reactions proceed in good yields for a range of aryl, heteroaryl, and vinyl amides. The subsequent Camps cyclization efficiently provides

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25

Job, Gabriel Ethan. "Copper-catalyzed arylation of 1,2-amino alcohols. Synthesis of N-terminal, peptide helix initiators, and characterization of highly helical, capped polyalanine peptides." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/32481.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2005.<br>Vita.<br>Includes bibliographical references.<br>I. An improved Ullmann reaction for N- or O-arylation of 1,2-aminoalcohols with aryl iodides is described. The procedures enjoy several advantages over traditional methods: a substoichiometric amount of copper catalyst is employed, the reactions take place in low boiling and non-toxic solvents such as isopropanol, the reactions occur at relatively low temperatures, and a variety of non-activated aryl iodide substrates may be used. II. Recent advances in solubili

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26

Sun, Xuetong. "Development of a new tridentate pincer phosphine N-heterocyclic carbene ligand & Development of a copper II catalyzed three component tandem synthesis of isoindolinone derivatives." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=97123.

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Two types of research were carried out in this thesis; the first section is about the development of a new phosphine-based tridentate pincer N-heterocyclic carbene ligand and examination of the catalytic activities of its transition metal compexes including conjugated addition, alkyne-aldehyde addition and Alkyne-Aldehyde-Amine (A-3) coupling reaction. The second section of the thesis is about the methodology development of an A-3 based tandem synthesis of isoindoline derivatives and gold (I) catalyzed cyclization for the synthesis of isoindolo[2,1-a]quinolines derivatives. The aim of these st

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27

Orre, Tommy. "Synthesis of modified silica using copper catalyzed click chemistry : Finding a procedure to attach corannulene to silica using click chemistry with the goal of separating fullerene isomers." Thesis, Umeå universitet, Kemiska institutionen, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-92605.

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28

Linstadt, Roscoe T. H. "A. Studies In The Allylic Substitution Chemistry Of Copper Hydride B. Stereoselective Silylcupration Of Conjugated Alkynes In Micellar Media C. Palladium-Catalyzed Synthesis Of 1,3-Butadienes and [3]-[6]Dendralenes D. Synthesis Of Small Molecule Underwater Adhesives Inspired By Mussels." Thesis, University of California, Santa Barbara, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10257794.

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<p> Copper hydride (CuH) has been shown to enable a number of selective 1,2- and 1,4-reductions when complexed with the appropriate ligand, yet the allylic substitution chemistry of CuH has been much less studied. This dissertation describes the further study of CuH to perform sequential reductions on Morita-Baylis-Hillman (MBH) adducts. Specifically: I) Selectivity in the SN2’ reduction of MBH adducts was shown to be highly dependant on the nature of the ligand used. II) The reaction of MBH alcohols was shown to involve an initial dehydrogenative silylation with PMHS, where both the oli

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29

Zhang, Yang [Verfasser], Norbert [Akademischer Betreuer] Krause та Ralf [Gutachter] Weberskirch. "Study of total synthesis of 9α,10β- Bisangeloyloxy-7-epi-3E-agerafastin and 3-O- Feruloylcassine by copper-mediated nucleophilic substitution and gold-catalyzed cycloisomerization / Yang Zhang ; Gutachter: Ralf Weberskirch ; Betreuer: Norbert Krause". Dortmund : Universitätsbibliothek Dortmund, 2019. http://d-nb.info/1195215983/34.

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30

Tadd, Andrew. "Palladium and copper catalysed heterocycle synthesis." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.504606.

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31

Ball, Catherine Jane. "Palladium- and copper-catalysed heterocycle synthesis." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:589b70fb-0823-4ccf-8b35-1883908f917d.

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A number of privileged starting materials based on aryl halide frameworks have emerged that allow access to a variety of different heterocyclic scaffolds through judicious choice of reaction conditions. This work describes efforts to develop and extend the utility of two of these general heterocycle precursors - ortho-(haloalkenyl)aryl halides A and α-(ortho-haloaryl) ketones B - in conjunction with cascade reactions involving the construction of key carbon-heteroatom bonds via palladium or copper catalysis. Chapter 1 entails an overview of the development of palladium- and copper-catalysed ca

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32

Dharap, Y. V. "Facile synthesis of aziridines using copper hydrotalcite under microwave irradiation; synthesis of 3-substituted2(1h)-quinolinones catalyzed by hydrotalcite like anionic clays; rearrangement of α-pinene epoxide to campholenic aldehyde with modified beta zeolite catalyst and regioselective nitration of phenols with new phosphorus based ionic liquids". Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2008. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2633.

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33

El-Batta, Amer Adnan. "Part I, copper(I) iodide dimethyl sulfide catalyzed 1,4-addition of alkenyl groups from alkenylzirconium and alkenylzinc reagents and their application toward the total synthesis of azaspirene ; Part II, aqueous Wittig chemistry employing stabilized ylides and aldehydes." Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2007. http://wwwlib.umi.com/cr/ucsd/fullcit?p3268346.

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Thesis (Ph. D.)--University of California, San Diego and San Diego State University, 2007.<br>Title from first page of PDF file (viewed August 7, 2007). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 265-280).

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Topping, Chris Mark. "Design and synthesis of chiral ligands for copper catalysed asymmetric synthesis." Thesis, University of Hull, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301496.

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35

Campbell, Matthew James Johnson Jeffrey Scott. "I. Mechanistic studies of a copper-catalyzed electrophilic amination of diorganozinc reagents reagents by O-benzoyl N,N-dialkylhydroxylamines II. Development of a 3-Exo-Dig cyclization for the preparation of vinylidene cyclopropanes III. Total synthesis of +-polyanthellin A." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2009. http://dc.lib.unc.edu/u?/etd,2881.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2010.<br>Title from electronic title page (viewed Jun. 23, 2010). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Chemistry." Discipline: Chemistry; Department/School: Chemistry.

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36

Poutrel, Pauline. "Réduction du motif vinyl-CF₃ : vers la synthèse catalytique énantiosélective de centres C-CF₃ et la synthèse diastéréosélective de monofluoroalcènes terminaux Copper‐catalyzed enantioselective formation of C−CF3 centers from β‐CF3‐substituted acrylates and acrylonitriles Stereoselective synthesis of terminal monofluoroalkenes from trifluoromethylated alkenes". Thesis, Normandie, 2020. http://www.theses.fr/2020NORMIR07.

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Ces dernières années, la chimie du fluor est devenue un domaine clé de recherche de par la présence croissante de l’atome du fluor dans les molécules issues de l’agrochimie, de l’industrie pharmaceutique et des matériaux. Il est alors nécessaire de développer de nouvelles méthodologies permettant la synthèse de ces molécules fluorées. Dans notre cas, il s’agit de mettre au point des procédures permettant l’obtention de synthons d’une part avec un centre stéréogène contrôlé comportant un motif trifluorométhyle, d’autre part avec un motif monofluoroalcène terminal. Dans un premier temps, nous av

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37

Toummini, Dounia. "Arylation de nucléophiles, par catalyse au cuivre ou au fer, ou en milieu superbasique en absence de métal de transition." Thesis, Montpellier, Ecole nationale supérieure de chimie, 2014. http://www.theses.fr/2014ENCM0001.

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Cette thèse s'inscrit dans le cadre très général de la recherche de nouvelles méthodes de synthèse éco-compatibles. Dans la première partie, intitulée « Arylation catalysée au cuivre d'hétérocycles azotés par des sels d'aryldiazonium», nous avons présenté nos travaux décrivant le premier exemple d'une réaction de type Sandmeyer permettant la formation d'une liaison carbone-azote (C-N). Nos systèmes permettent, en effet, l'arylation de nucléophiles azotés, essentiellement de type pyrazole, à partir d'électrophiles d'aryldiazoniums. Les motifs obtenus, les arylpyrazoles, sont des molécules extrê

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38

Brittain, William David George. "Asymmetric synthesis 1,2,3-triazoles utilising the copper-catalysed azide-alkyne cycloaddition." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8143/.

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The copper-catalysed azide-alkyne cycloaddition (CuAAC) is a highly efficient reaction and is the cornerstone of “click” chemistry. However, unlike many common metal-mediated transformations asymmetric CuAAC variants are relatively sparse. This thesis details asymmetric “click” reactions with Chapter 1 introducing the CuAAC and the asymmetric variants already present in the literature. Chapter 2 outlines research demonstrating the first example of kinetic resolution of an alkyne via a CuAAC reaction. Selectivity factors of up to 22.1 ± 0.5 were obtained and triazoles and alkynes were obtained

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39

Gorman, Ryan. "Copper-catalysed synthesis of 5- and 6-membered nitrogen-containing heterocycles." Thesis, University of York, 2016. http://etheses.whiterose.ac.uk/16167/.

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Nitrogen-containing heterocycles are an important structural motif, prevalent in both nature and medicine. N-Heterocycles can be found at the core of numerous biologically active molecules resulting in a huge amount of attention focussed on the novel synthesis of these privileged motifs from both academic and industrial researchers alike. In recent years the importance of developing efficient, “green” and cost effective routes to medicinal agents has become increasingly at the forefront of modern research. In 2009 the Taylor group reported the successful synthesis of oxindole heterocycles via

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40

Foltz-César, Carole. "Trisoxazolines : Synthesis and application in enantioselective palladium- and copper-catalysed reactions." Strasbourg 1, 2007. https://publication-theses.unistra.fr/public/theses_doctorat/2007/FOLTZ-CESAR_Carole_2007.pdf.

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Le but de ce travail a été de concevoir de nouveaux ligands trisoxazolines de haute symétrie et de déterminer leur intérêt par rapport aux ligands de symétrie C2 bien établis dans la littérature. Une étude directe de l’influence de la symétrie C3 en catalyse asymétrique par comparaison directe entre des systèmes trisoxazoline/métal et bisoxazoline/métal a donc été effectuée. Dans un premier temps, trois nouvelles trisoxazolines de symétrie C3 ont été synthétisées avec, sur les cycles oxazoline, les substituants chiraux phenyl, benzyl et indanyl. Des bisoxazolines et trisoxazolines à groupement

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41

Foltz-Cesar, Carole. "Trisoxazolines: synthesis and application in enantioselective palladium- and copper-catalysed reactions." [S.l. : s.n.], 2007. http://nbn-resolving.de/urn:nbn:de:bsz:16-opus-79452.

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42

Van, Der Waals Dominic. "Atom economical and environmentally benign metal catalysed synthesis." Thesis, University of Bath, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.636541.

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The use of inexpensive metal catalysts for a range of acylation reactions including the activation of anhydrides and the aminolysis of esters. Discussion on the use of a heterogeneous copper catalyst for teh reduction of a range of organic functional groups and its use in amination of nitriles.

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Male, Henry Peter John. "Towards the development, application and understanding of copper-catalysed alkene functionalisation processes using iodonium salts." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/273476.

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This thesis comprises three projects focused on the use of the combination of catalytic copper and iodonium salts towards the functionalisation of alkenes. Chapter 2 details the development of an enantioselective and regiodivergent allylic amide arylation procedure using a specific copper(II)-bisoxazoline pre-catalyst and hexafluorophosphate diaryliodonium salts. The regioselectivity of the process was discovered to be controlled by the electronic properties of the iodane employed, allowing enamide production to be biased with electron-poor iodonium salts and oxazines to be produced with elect

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44

Muldowney, Mark Patrick. "Mechanistic and synthetic studies of copper catalysed aziridination of alkenes." Thesis, University of Newcastle Upon Tyne, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297570.

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Welker, Matthias J. H. "Development and synthetic applications of asymmetric copper-catalysed conjugate addition reactions." Thesis, University of Nottingham, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.537676.

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46

Baboo, Sabyasachi. "Nuclear translation." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:5266f049-d576-44fd-ab26-11cf7a27f678.

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In bacteria, protein synthesis can occur tightly coupled to transcription. In eukaryotes, it is believed that translation occurs solely in the cytoplasm; I test whether some occurs in nuclei and find: (1) L-azidohomoalanine (Aha) – a methionine analogue (detected by microscopy after attaching a fluorescent tag using ‘click’ chemistry) – is incorporated within 5 s into nuclei in a process sensitive to the translation inhibitor, anisomycin. (2) Puromycin – another inhibitor that end-labels nascent peptides (detected by immuno-fluorescence) – is similarly incorporated in a manner sensitive to a t

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47

Hodgkinson, Roy. "Synthesis of indoles and azaindoles via copper/palladium catalysed tandem C-N bond coupling." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.504479.

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Nikolaidi, B. "First principles investigation of nanoscale processes involved in the copper-catalysed synthesis of methanol." Thesis, University of Manchester, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505815.

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This treatise is based on first-principles of the nano-scale properties of methanol synthesis on copper. We implement calculations using density functional theory within the framework of general gradient approximation. Initially, we gain insights into the mechanism of hydrogen dissociative adsorption on Cu(100) and find that the process is activated and the transition state involves an extended H... H bond. Hydrogens adsorb preferentially at surface hollows and upon saturation of these, penetrate lattice bulk and occupy interstitials. We proceed by monitoring the adsorption of atomic hydrogen

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49

Fabre, Indira. "Experimental and theoretical mechanistic studies of transition-metal free and copper-catalyzed reactions." Thesis, Paris Sciences et Lettres (ComUE), 2017. http://www.theses.fr/2017PSLEE033/document.

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Cette thèse présente des travaux de méthodologie de synthèse et des études mécanistiques. Une approche complémentaire est utilisée, avec des résultats expérimentaux et des résultats théoriques issus de calculs DFT. Trois réactions ont été étudiées. La première réaction est l’alpha-arylation de cétones énolisables en l’absence de métal de transition. Elle se déroule en présence de DMF et de tBuOK. L’étude mécanistique met en évidence la formation d’une espèce riche en électrons par déprotonation du solvant. La deuxième réaction étudiée est la N-arylation de pyrazoles via la formation d’aryldiaz

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50

Wang, Yi. "Stereoselective synthesis of multisubstituted alkenes via ring opening reactions of cyclopropenes : enantioselective copper catalysed asymmetric reduction of alkenylheteroarenes." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4607.

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A catalytic organometallic addition-ring opening sequence of cyclopropenes that enables the efficient and highly stereoselective synthesis of multisubstituted alkenes has been developed. A possible mechanism of organoaluminium reaction is proposed. The metalloenolate resulting from ring opening can be trapped with various electrophiles, enabling a rapid increase in molecular complexity in a one-pot operation. Also, in the presence of stoichiometric magnesium halides, a range of bis-activated cyclopropenes undergo highly stereoselective ring-opening reactions to produce multisubstituted alkenyl

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