Academic literature on the topic 'Copper(II) Curcumin Complexes'

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Journal articles on the topic "Copper(II) Curcumin Complexes"

1

Le Dang Khoa and Hoang Minh Hao. "Synthesis, characterization and evaluation of antibacterial activity of copper(II)-curcumin complex against staphylococcus aureus." Journal of Technical Education Science, no. 67 (December 17, 2021): 52–57. http://dx.doi.org/10.54644/jte.67.2021.1089.

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Curcumin, a phytochemical from turmeric, and its derivatives have been extensively investigated from both chemical and biological strategies. However, the main problem encountered while using curcumin in clinical trials is its poor solubility and rapid degradation, resulting in its low levels in tissues, thus decreasing the medicinal effect of curcumin. To overcome these problems several synthetic approaches have been carried out to prepare new derivatives possessing better properties. Curcumin as a β-diketone ligand can act as chelating ligands toward a variety of metals to form stable complexes. Some studies showed that a metal-curcumin complex displayed potential medicinal activities. In this work, a copper(II)-curcumin complex was synthesized in a two-step procedure: (i) curcumin was separated from commercial turmeric powder using chromatography techniques and (ii) the copper(II) chloride (1 eq.) and pure curcumin (2 eq.) were mixed together in ethanol. The mixture was stirred at 60 oC for 3 hours to afford a stoichiometric copper(II)-curcumin complex. The curcumin ligand and its copper(II) complex were characterized by UV-Vis, IR, NMR spectroscopic methods, from which it was found that copper atoms are coordinated through keto-enol groups of two curcumin molecules. The ground state spectral features of the copper(II)-curcumin complex were consistent with that of the 1:2 copper(II)-curcumin complex. The antibacterial activities of curcumin ligand and its complex were evaluated against Staphylococcus aureus (ATCC 6538) using a well diffusion method on nutrient agar. The results showed that the inhibitory activity was not observed for free curcumin at any concentrations while the copper(II)-curcumin complex exhibited the inhibition zones (mm) of 7.8, 11.6 and 14.9 at various concentrations (mg/mL) of 1.0, 5.0 and 15.0, respectively.
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2

Banaspati, Atrayee, Vanitha Ramu, Md Kausar Raza, and Tridib K. Goswami. "Copper(ii) curcumin complexes for endoplasmic reticulum targeted photocytotoxicity." RSC Advances 12, no. 47 (2022): 30722–33. http://dx.doi.org/10.1039/d2ra04813b.

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3

H. M. Leung, Mandy, Takaaki Harada, and Tak W. Kee. "Delivery of Curcumin and Medicinal Effects of the Copper(II)-Curcumin Complexes." Current Pharmaceutical Design 19, no. 11 (2013): 2070–83. http://dx.doi.org/10.2174/1381612811319110008.

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H. M. Leung, Mandy, Takaaki Harada, and Tak W. Kee. "Delivery of Curcumin and Medicinal Effects of the Copper(II)-Curcumin Complexes." Current Pharmaceutical Design 19, no. 11 (2013): 2070–83. http://dx.doi.org/10.2174/138161213805289237.

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5

Bhattacharyya, Arnab, Akanksha Dixit, Koushambi Mitra, Samya Banerjee, Anjali A. Karande, and Akhil R. Chakravarty. "BODIPY appended copper(ii) complexes of curcumin showing mitochondria targeted remarkable photocytotoxicity in visible light." MedChemComm 6, no. 5 (2015): 846–51. http://dx.doi.org/10.1039/c4md00425f.

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6

Leung, Mandy H. M., Duc-Truc Pham, Stephen F. Lincoln, and Tak W. Kee. "Femtosecond transient absorption spectroscopy of copper(ii)–curcumin complexes." Physical Chemistry Chemical Physics 14, no. 39 (2012): 13580. http://dx.doi.org/10.1039/c2cp40208d.

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7

Arenaza-Corona, Antonino, Marco A. Obregón-Mendoza, William Meza-Morales, et al. "The Homoleptic Curcumin–Copper Single Crystal (ML2): A Long Awaited Breakthrough in the Field of Curcumin Metal Complexes." Molecules 28, no. 16 (2023): 6033. http://dx.doi.org/10.3390/molecules28166033.

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The first single crystal structure of the homoleptic copper (II) ML2 complex (M=Cu (II), L = curcumin) was obtained and its structure was elucidated by X-ray diffraction showing a square planar geometry, also confirmed by EPR. The supramolecular arrangement is supported by C-H···O interactions and the solvent (MeOH) plays an important role in stabilizing the crystal packing Crystallinity was additionally assessed by XRD patterns. The log P value of the complex (2.3 ± 0.15) was determined showing the improvement in water solubility. The cytotoxic activity of the complex against six cancer cell lines substantially surpasses that of curcumin itself, and it is particularly selective against leukemia (K562) and human glioblastoma (U251) cell lines, with similar antioxidant activity to BHT. This constitutes the first crystal structure of pristine curcumin complexed with a metal ion.
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8

Mukherjee, Nandini, Abinaya Raghavan, Santosh Podder, et al. "Photocytotoxic Activity of Copper(II) and Zinc(II) Complexes of Curcumin and (Acridinyl)dipyridophenazine." ChemistrySelect 4, no. 33 (2019): 9647–58. http://dx.doi.org/10.1002/slct.201902281.

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9

Goswami, Tridib K., Sudarshan Gadadhar, Bappaditya Gole, Anjali A. Karande, and Akhil R. Chakravarty. "Photocytotoxicity of copper(II) complexes of curcumin and N-ferrocenylmethyl-l-amino acids." European Journal of Medicinal Chemistry 63 (May 2013): 800–810. http://dx.doi.org/10.1016/j.ejmech.2013.03.026.

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10

Annaraj, James P., Kanagasabai M. Ponvel, Periakaruppan Athappan, and Sankaran Srinivasan. "Synthesis, spectra and redox behavior of copper(II) complexes of curcumin diketimines as models for blue copper proteins." Transition Metal Chemistry 29, no. 7 (2004): 722–27. http://dx.doi.org/10.1007/s11243-004-0837-9.

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