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Journal articles on the topic 'Coprolalia'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Finkelstein, Shlomit Ritz, Rob Poh, and Jorge L. Juncos. "Swearing: Language for Feeling." Cognitive Semantics 2, no. 2 (2016): 237–61. http://dx.doi.org/10.1163/23526416-00202005.

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We hypothesize that swearing is an emotional action that hardly says anything other than expressing and evoking emotions and that studying swearing might shed light on the evolutionary path from motor behavior to language. Our lens is the involuntary swearing—coprolalia—associated with Tourette syndrome (ts). In a qualitative analysis of videotaped interviews with 16 ts sufferers and their families, we arrive at the following findings, of which the first one replicates previous findings, and the following are novel: (i) coprolalia, once believed psychogenic, is embodied; (ii) the pragmatics of

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2

Wagner-Altendorf, Tobias A., Veit Roessner, and Thomas F. Münte. "Swearing, Cursing, Coprophenomena." Zeitschrift für Neuropsychologie 30, no. 4 (2019): 250–55. http://dx.doi.org/10.1024/1016-264x/a000277.

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Abstract. In healthy individuals, expletive language occurs as swearing/cursing, in patients with Tourette syndrome as coprolalia. Swearing and coprolalia thus have been likened as two ends of a continuum. Both occur apparently automatically, are triggered by emotional activation, e. g., by stress or pain, and are typically instantiations of nonpropositional language. Neurobiologically, a thalamo-cortical-limbic dysfunction is discussed. However, there are notable differences between the two: While swearing fulfills intra- and inter-individual functions coprolalia seems less functional and can

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3

Martí-Massó, J. F., and J. A. Obeso. "Coprolalia Associated with Hemiballismus." Clinical Neuropharmacology 8, no. 2 (1985): 189–90. http://dx.doi.org/10.1097/00002826-198506000-00009.

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4

Singer, Carlos. "COPROLALIA AND OTHER COPROPHENOMENA." Neurologic Clinics 15, no. 2 (1997): 299–308. http://dx.doi.org/10.1016/s0733-8619(05)70314-5.

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5

PITMAN, ROGER K., and MICHAEL A. JENIKE. "Coprolalia in Obsessive-Compulsive Disorder." Journal of Nervous and Mental Disease 176, no. 5 (1988): 311–13. http://dx.doi.org/10.1097/00005053-198805000-00012.

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6

Sumit, Kumar Gupta. "A Child of Wilson's Disease Presenting with Coprolalia." Annals of Psychiatry and Treatment 2, no. 1 (2017): 001–2. https://doi.org/10.17352/apt.000002.

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Wilson’s disease is a rare autosomal recessive genetic disorder of copper metabolism. Neurological and psychiatric manifestations can be a presenting manifestation of Wilson’s disease. We describe a case of a 13 year old child diagnosed with Wilson’s disease who presented with coprolalia (complex vocal tics). Tics can be present in Wilson’s disease, but they are usually described to be simple motor tics. Vocal tics especially complex vocal tics and that too specifi cally coprolalia has not been described previously in the literature to the best of our knowledge.

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7

Pamungkas, Sri. "Forms of Linguistic Deviations Found in Latah Coprolalia Behavior in Jombang, East Java, Indonesia." Jurnal Humaniora 34, no. 1 (2022): 61. http://dx.doi.org/10.22146/jh.68090.

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Latah is a psychogenic language disorder in Malay and Indonesian society stemming from cultural pressure, mimicry, and the like. It is expressed as a verbal or nonverbal response to surprise or shock. The focus of this research was the form of linguistic deviation in individuals in Jombang, East Java, with latah coprolalia behavior, specifically latah behavior by expressing lingual forms that refer to the male or female genitalia. Data collection comprised observations and interviews, while data analysis used Spardley’s ethnographic approach with four advanced paths: (1) domain analysis, (2) t

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8

Maling, Samuel, Justus Byarugaba, and Richard Idro. "Compulsive behavior and coprolalia after cerebral malaria." Journal of Pediatric Neurology 03, no. 02 (2015): 107–8. http://dx.doi.org/10.1055/s-0035-1557252.

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9

Berthier, Marcelo L., Victor M. Campos, Jaime Kulisevsky, and Juan A. Valero. "Heroin and Malignant Coprolalia in Tourette's Syndrome." Journal of Neuropsychiatry and Clinical Neurosciences 15, no. 1 (2003): 116–17. http://dx.doi.org/10.1176/jnp.15.1.116.

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10

Massot-Tarrús, Andreu, Seyed Reza Mousavi, Carin Dove, et al. "Coprolalia as a manifestation of epileptic seizures." Epilepsy & Behavior 60 (July 2016): 99–106. http://dx.doi.org/10.1016/j.yebeh.2016.04.040.

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11

Maia, Débora Palmini, and Francisco Cardoso. "Complex phonic tic and disinhibition in Tourette syndrome: case report." Arquivos de Neuro-Psiquiatria 59, no. 3A (2001): 587–89. http://dx.doi.org/10.1590/s0004-282x2001000400019.

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Tourette syndrome (TS) is a neuropsychiatric disorder characterized by a combination of multiple motor tics and at least one phonic tic. TS patients often have associated behavioral abnormalities such as obsessive compulsive disorder, attention deficit and hyperactive disorder. Coprolalia, defined as emission of obscenities or swearing, is one type of complex vocal tic, present in 8% to 26% of patients. The pathophysiology of coprolalia and other complex phonic tics remains ill-defined. We report a patient whose complex phonic tic was characterized by repetitively saying "breast cancer" on see

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12

Teive, Hélio A. G., Francisco M. B. Germiniani, Marcus V. Della Coletta, and Lineu César Werneck. "Tics and Tourette syndrome: clinical evaluation of 44 cases." Arquivos de Neuro-Psiquiatria 59, no. 3B (2001): 725–28. http://dx.doi.org/10.1590/s0004-282x2001000500014.

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We evaluated 44 patients with tics and Tourette's syndrome (TS) emphasising the age of onset of symptoms, sex, classification and localization of tics, associated symptoms and signs and comorbidities. Thirty-three patients (75.2%) had TS defined criteria whereas 10 (22.7%) had chronic motor and/or vocal tics. Simple motor tics were found in 43 cases (97.7%), mainly affecting the eyes (43.2%), mouth (43.2%), face (34.1%). Simple vocal tics occurred in 33 (75%). Coprolalia was found in just 6 cases (13.6%) and copropraxia in just 2 (4.5%). Obsessive compulsive disorder and/or symptoms were found

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13

Garg, B., and SK Gupta. "A Child of Wilson’s Disease Presenting with Coprolalia." Annals of Psychiatry and Treatment 2, no. 1 (2017): 001–2. http://dx.doi.org/10.17352/apt.000002.

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14

Chiu, A., and W. McAuliffe. "A 42-year-old man with “pseudo-coprolalia”." Journal of Clinical Neuroscience 17, no. 7 (2010): 954–55. http://dx.doi.org/10.1016/j.jocn.2009.10.030.

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15

Müller-Vahl, Kirsten R. "Monolingual coprolalia in bilingual patients with Tourette syndrome." Movement Disorders 27, no. 11 (2012): 1468. http://dx.doi.org/10.1002/mds.25166.

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16

Eapen, V., and M. M. Robertson. "Gilles de la Tourette Syndrome—A Case Report from Guyana in South America." Behavioural Neurology 5, no. 1 (1992): 39–41. http://dx.doi.org/10.1155/1992/929671.

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A case of the Gilles de la Tourette syndrome from Guyana in South America is presented. The patient had a positive family history as well as coprolalia, echolalia, and attention deficit disorder with hyperactivity. The family history and cross-cultural similarity emphasise the biological factors in the aetiology of the syndrome.

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17

Panunzi, Sara, Francesco Cardona, Paola De Liso, Mario Brinciotti, and Andrea E. Cavanna. "Ictal Coprolalia in a Patient With Temporal Lobe Epilepsy." Journal of Neuropsychiatry and Clinical Neurosciences 25, no. 4 (2013): E48—E49. http://dx.doi.org/10.1176/appi.neuropsych.12120379.

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18

Brown, Kate E., and Howard I. Kushner. "Eruptive Voices: Coprolalia, Malediction, and the Poetics of Cursing." New Literary History 32, no. 3 (2001): 537–62. http://dx.doi.org/10.1353/nlh.2001.0028.

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19

Byrne, E. Jane. "Coprolalia vocal tics and depressive illness: A case report." International Journal of Geriatric Psychiatry 4, no. 1 (1989): 55–57. http://dx.doi.org/10.1002/gps.930040113.

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20

Janik, Piotr, Anna Dunalska, Natalia Szejko, and Andrzej Jakubczyk. "Cognitive Tic-Like Phenomena in Gilles de la Tourette Syndrome." Journal of Clinical Medicine 10, no. 13 (2021): 2749. http://dx.doi.org/10.3390/jcm10132749.

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Coprolalia and echophenomena repeated in the patients’ mind (CTPh—cognitive tic-like phenomena) have been rarely recognized as part of Gilles de la Tourette syndrome (GTS) symptomatology and their assignment to tics, OCD or other psychopathologies has not been settled. The aim of the paper was to assess the incidence and clinical associations of CTPh in GTS, and to establish if CTPh belong to the tic spectrum. We performed a prospective, one-registration study on a cohort of 227 consecutive patients with GTS. CTPh were diagnosed during the interview and defined as brief, sudden, involuntary th

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21

Goldenberg, James N., Stuart B. Brown, and William J. Weiner. "Coprolalia in younger patients with Gilles de la tourette syndrome." Movement Disorders 9, no. 6 (1994): 622–25. http://dx.doi.org/10.1002/mds.870090607.

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22

Apaydin, Hulya, Gulçin Benbir, and Andrew Lees. "A stimulus-sensitive tic disorder characterized by echophenomena and coprolalia." Movement Disorders 27, no. 1 (2011): 159–60. http://dx.doi.org/10.1002/mds.23952.

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23

Robertson, Mary M., and Dan Z. Reinstein. "Convulsive Tic Disorder Georges Gilles de la Tourette, Guinon and Grasset on the Phenomenology and Psychopathology of Gilles de la Tourette Syndrome." Behavioural Neurology 4, no. 1 (1991): 29–56. http://dx.doi.org/10.1155/1991/505791.

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Gilles de la Tourette gained eponymous fame when he described nine cases of multiple tics, coprolalia and echolalia, and later he, Guinon and Grasset were the first to document the psychopathology of the Gilles de la Tourette syndrome. In particular, they noted the association between obsessional thoughts and behaviours and the tic disorder. In this paper we present the first English translations of their works referring to the psychopathology, comparing and contrasting their ideas to current concepts.

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24

Jankovic, Joseph, and Haydee Rohaidy. "Motor, Behavioral and Pharmacologic Findings in Tourette's Syndrome." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 14, S3 (1987): 541–46. http://dx.doi.org/10.1017/s0317167100038087.

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ABSTRACT:We studied 112 patients with Tourette's syndrome (TS); the male-to-female ratio was 3.8, the mean age of onset was 7.3 years, and the average duration of symptoms prior to the initial evaluation was 15.2 years. Seventy-nine percent of the patients had at least one family member with motor or vocal tics, and an additional 10 percent had a family member with marked obsessive-compulsive behavior. Simple motor tics occurred as the presenting symptom in about one-third of patients; one-third had multiple motor tics at the onset, and another third started with vocal tics. During the course

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25

Kobierska, Magdalena, Martyna Sitek, Katarzyna Gocyła, and Piotr Janik. "Coprolalia and copropraxia in patients with Gilles de la Tourette syndrome." Neurologia i Neurochirurgia Polska 48, no. 1 (2014): 1–7. http://dx.doi.org/10.1016/j.pjnns.2013.03.001.

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26

Sağlam, Ebru, and Ayhan Bilgiç. "Coprolalia Successfully Treated With Aripiprazole in a Child With Tourette Syndrome." Clinical Neuropharmacology 42, no. 4 (2019): 147. http://dx.doi.org/10.1097/wnf.0000000000000353.

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27

Gates, Larry, James R. Clarke, Aidan Stokes, et al. "Neuroanatomy of coprolalia in Tourette syndrome using functional magnetic resonance imaging." Progress in Neuro-Psychopharmacology and Biological Psychiatry 28, no. 2 (2004): 397–400. http://dx.doi.org/10.1016/j.pnpbp.2003.10.017.

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28

Aedo, Sergio, and Miguel Farías. "Etnofaulismos, coprolalia, representaciones y estrategias discriminatorias: el caso del discurso chileno antiperuano." Discurso & Sociedad 3, no. 3 (2009): 372–96. http://dx.doi.org/10.14198/dissoc.3.3.1.

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En este artículo se da cuenta de las dimensiones explícitas e implícitas del discurso racista chileno antiperuano. Por una parte, abordamos el estudio de las expresiones peyorativas (etnofaulismos) y coprolálicas para referirse a grupos de inmigrantes encontradas en periódicos chilenos de 1879 y en sitos de Internet. Por otra parte, el discurso racista antiperuano implícito lo analizamos críticamente por medio de las representaciones y estrategias discursivas utilizadas por una muestra de mujeres del estrato socioeconómico alto de Santiago de Chile. Nos proponemos constatar la continuidad hist

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29

Salles, P., M. Sy, H. Fernandez, and M. Gostkowski. "Dramatic response of coprolalia to dronabinol in Tourette syndrome: A case report." Parkinsonism & Related Disorders 79 (October 2020): e109. http://dx.doi.org/10.1016/j.parkreldis.2020.06.395.

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30

Rickards, Hugh. "Signing coprolalia and attempts to disguise in a man with prelingual deafness." Movement Disorders 16, no. 4 (2001): 790–91. http://dx.doi.org/10.1002/mds.1158.

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31

Tanjung, Andi Saputra, Gustianingsih Gustianingsih, and Syahron Lubis. "KAJIAN PSIKOLINGUISTIK TERHADAP BENTUK DAN FUNGSI LINGUAL LATAH: STUDI KASUS WARGA MEDAN." MEDAN MAKNA: Jurnal Ilmu Kebahasaan dan Kesastraan 17, no. 2 (2019): 144. http://dx.doi.org/10.26499/mm.v17i2.2137.

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hyperstartle syndrome is interesting to research using psycholinguistic study. This research electorates the linguistic form of language of the residents in Jalan Garu III, Medan Amplas, Kota Medan. The qualitative data are words and sentences that used in behavior in Jalan Garu III, Medan Amplas, Kota Medan. The result of the research is the description of the linguistic forms of talkative behavior in the form of words and sentences, including: (1) coprolalia talkative behavior, (2) ecolalia talkative behavior, (3) autoecolalia talkative behavior, (4) automatic obedience talkative behavior. T

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32

Delgado, Pedro L., Wayne K. Goodman, Lawrence H. Price, George R. Heninger, and Dennis S. Charney. "Fluvoxamine/Pimozide Treatment of Concurrent Tourette's and Obsessive-Compulsive Disorder." British Journal of Psychiatry 157, no. 5 (1990): 762–65. http://dx.doi.org/10.1192/bjp.157.5.762.

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A 25–year-old man with a history of Tourette's syndrome presented for treatment of OCD symptoms. Fluvoxamine worsened tics, led to coprolalia, and did not help the OCD. The addition of pimozide dramatically reduced both OCD and Tourette's symptoms. Double-blind sequential discontinuation of fluvoxamine and pimozide confirmed that pimozide alone reduced only tics and the combination of fluvoxamine and pimozide was required for the improvement in OCD. Tics may reflect a subtype of OCD. Some OCD patients unresponsive to a 5–HT reuptake inhibitor alone may benefit from the addition of a dopamine a

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33

Jadresic, Danitza. "The Role of the Amygdaloid Complex in Gilles de la Tourette's Syndrome." British Journal of Psychiatry 161, no. 4 (1992): 532–34. http://dx.doi.org/10.1192/bjp.161.4.532.

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Gilles de la Tourette's syndrome (GTS) is a relatively rare neuropsychiatric disorder characterised by multiple motor tics accompanied by vocalisations. It usually starts in early childhood and is more common in males than females. Obsessional compulsive disorder (OCD) is an integral part of GTS (Robertson, 1989). GTS is also associated with coprolalia, copropraxia, and other echophenomena, as well as attention-deficit disorder, self-injury, and other behaviour problems (Robertson et al, 1988; Robertson, 1989). Family pedigree studies have demonstrated that most GTS cases in the community are

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34

Ganos, Christos, Mark J. Edwards, and Kirsten Müller-Vahl. "“I swear it is Tourette's!”: On functional coprolalia and other tic-like vocalizations." Psychiatry Research 246 (December 2016): 821–26. http://dx.doi.org/10.1016/j.psychres.2016.10.021.

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35

Afshangian, Fazlallah, Mohammad Nami, Amin Abolhasani Foroughi, et al. "Coprolalia in aphasic patients with stroke: a longitudinal observation from the BLAS2T database." Neurocase 23, no. 5-6 (2017): 249–62. http://dx.doi.org/10.1080/13554794.2017.1387274.

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36

Yorston, Graeme, and Nick Hindley. "Study of a nervous disorder characterized by motor incoordination with echolalia and coprolalia." History of Psychiatry 9, no. 33 (1998): 097–101. http://dx.doi.org/10.1177/0957154x9800903307.

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37

Ben Djebara, Mouna, Yulia Worbe, Michael Schüpbach, and Andreas Hartmann. "Aripiprazole: A treatment for severe coprolalia in “refractory” Gilles de la Tourette syndrome." Movement Disorders 23, no. 3 (2007): 438–40. http://dx.doi.org/10.1002/mds.21859.

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38

Budi Rizka and Lismalinda Lismalinda. "THE CHARACTERISTICS OF CULTURE-BOUND SYNDROME OF ACEHNESE SPEAKERS IN A SOCIOPSYCHOLINGUISTICS PERSPECTIVE." Getsempena English Education Journal 9, no. 1 (2022): 29–42. http://dx.doi.org/10.46244/geej.v9i1.1661.

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This study aims to classify the characteristics of Culture-Bound Syndrome in Acehnese speakers from the perspective of Socio-Psycholinguistics, particularly in Aceh Besar, Pidie, and Aceh Utara by comparing gender, age, and the education level of the patient. The researchers chose to use a case study approach to conduct data to be able to provide an overview of the characteristics of Culture-Bound Syndrome behaviour displayed. In analysing the data, the researcher refers to Spradley Theory who said that analytical technique with four advanced paths, namely (1) domain analysis; (2) taxonomy ana

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39

Hartman, Geoffrey. "Trauma and Literature: The Case of Christopher Smart." Eighteenth-Century Studies 57, no. 4 (2024): 531–46. http://dx.doi.org/10.1353/ecs.2024.a931696.

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Abstract: This essay explores how Jubilate Agno responds to a situation analogous to trauma and mania—although its coordinates are as much historical and linguistic as psychological—in which poetic self-presentation is so thwarted as to verge on aphasia. Smart's poem circumvents social and other curtailments of speech by finding undeveloped expressive powers in language and the semiotic process: a mode of representation that Smart called "sound reasoning." Hartman traces this sound reasoning through key sequences on language in Jubilate Agno , showing how it turns coprolalia and other dysphemi

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40

Weiblen, Ronja, Melanie Jonas, Sören Krach, and Ulrike M. Krämer. "Social Cognition in Gilles de la Tourette Syndrome." Zeitschrift für Neuropsychologie 30, no. 4 (2019): 243–49. http://dx.doi.org/10.1024/1016-264x/a000272.

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Abstract. Research on the neural mechanisms underlying Gilles de la Tourette syndrome (GTS) has mostly concentrated on abnormalities in basal ganglia circuits. Recent alternative accounts, however, focused more on social and affective aspects. Individuals with GTS show peculiarities in their social and affective domain, including echophenomena, coprolalia, and nonobscene socially inappropriate behavior. This article reviews the experimental and theoretical work done on the social symptoms of GTS. We discuss the role of different social cognitive and affective functions and associated brain net

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41

KANO, YUKIKO, MASATAKA OHTA, and YOKO NAGAI. "Differences in clinical characteristics between Tourette syndrome patients with and without ‘generalized tics' or coprolalia." Psychiatry and Clinical Neurosciences 51, no. 6 (1997): 357–62. http://dx.doi.org/10.1111/j.1440-1819.1997.tb02599.x.

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42

Chien, Hsin Fen, Egberto Reis Barbosa, and Eurípedes Constantino Miguel. "Síndrome de Gilles de la Tourette: estudo clínico de 58 casos." Arquivos de Neuro-Psiquiatria 59, no. 3B (2001): 729–32. http://dx.doi.org/10.1590/s0004-282x2001000500015.

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A síndrome de Gilles de la Tourette (SGT) é um transtorno neuropsiquiátrico, de início na infância, caracterizado pela presença de tiques motores e vocais. Cinquenta e oito pacientes com SGT foram acompanhados clinicamente durante período de três anos. Trinta e seis pacientes eram do sexo masculino e 22 do feminino, a proporção entre os sexos foi 1,6:1. A idade dos pacientes variou de 7 a 50 anos, média 20,33 anos. A idade de início dos sintomas variou de 3 a 15 anos, sendo a média 7,81 anos. O tique motor foi o sintoma inaugural em 79% dos pacientes. Quanto aos tiques complexos, a coprolalia

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43

Yogaratnam, Jegan, Changqing Xu, Daw San San Thinn, Lee Kim Yoong, Chai Ling Khoo, and Kang Sim. "De novo Tardive Tourette‐like syndrome after prolonged combination depot and oral neuroleptic therapy." Acta Neuropsychiatrica 25, no. 2 (2013): 122–24. http://dx.doi.org/10.1111/acn.12009.

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IntroductionTardive Tourette‐like syndrome is recognised by the observation of several motor and vocal tics often in individuals receiving psychotropic medications and can happen within 1–3 months of treatment.Clinical caseWe report a case which is unique in its onset of Tardive Tourette‐like syndrome comprising of vocal, motor tics and coprolalia after more than three decades of treatment with combination depot and oral neuroleptics.DiscussionUse of the Naranjo Adverse Drug Reaction Probability Scale indicates a probable relationship between the onset of Tardive Tourettism and the antipsychot

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44

Daniel, Cerin, and M. Scott Perry. "Ictal Coprolalia: A Case Report and Review of Ictal Speech as a Localizing Feature in Epilepsy." Pediatric Neurology 57 (April 2016): 88–90. http://dx.doi.org/10.1016/j.pediatrneurol.2015.11.013.

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45

Xu, Cuiping, Kai Ma, Xi Zhang, et al. "Ictal coprolalia occurs due to the activation of the temporal-orbitofrontal network in patients with epilepsy." Journal of the Neurological Sciences 409 (February 2020): 116634. http://dx.doi.org/10.1016/j.jns.2019.116634.

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46

De La Tourette, Gilles. "Study of a nervous affliction characterized by motor incoordination with echolaha and coprolalia (Jumping, Latah, Myriachit." History of Psychiatry 9, no. 33 (1998): 102–20. http://dx.doi.org/10.1177/0957154x9800903308.

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47

Scott, Burton L., Joseph Jankovic, and Donald T. Donovan. "Botulinum toxin injection into vocal cord in the treatment of malignant coprolalia associated with Tourette's syndrome." Movement Disorders 11, no. 4 (1996): 431–33. http://dx.doi.org/10.1002/mds.870110413.

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48

Mubarok, Ahmad, Faisal Rahman, and Fajrianor Fajrianor. "LATAH: A CLINICAL LINGUISTIC REVIEW." LET: Linguistics, Literature and English Teaching Journal 10, no. 1 (2020): 66. http://dx.doi.org/10.18592/let.v10i1.3845.

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This study describes the speech disorder in latah patients in terms of phonology with the Clinical Linguistic approach. Latah is a linguistic behaviour that occurs when someone is shocked, accidentally issuing words spontaneously and not aware of what he/she is saying. The the subjects of the study were severe latah sufferers namely latah echolalia, coprolalia, and automatic obedience, totalling 3 people. The words spoken by latah sufferers become research material and are reviewed from the phonological aspect in a clinical linguistic perspective. The main requirement for latah people is shock

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49

Earles, Theresa L., and Brenda Smith Myles. "Using Behavioral Interventions to Decrease Coprolalia in a Student with Tourette's Syndrome and Autism: A Case Study." Focus on Autistic Behavior 8, no. 6 (1994): 1–10. http://dx.doi.org/10.1177/108835769400800601.

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50

Segar, David J., Yosef G. Chodakiewitz, Radmehr Torabi, and G. Rees Cosgrove. "Deep brain stimulation for the obsessive-compulsive and Tourette-like symptoms of Kleefstra syndrome." Neurosurgical Focus 38, no. 6 (2015): E12. http://dx.doi.org/10.3171/2015.3.focus1528.

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Abstract:

Deep brain stimulation (DBS) has been reported to have beneficial effects in severe, treatment-refractory cases of obsessive-compulsive disorder (OCD) and Tourette syndrome (TS). In this report, the authors present the first case in which DBS was used to treat the neuropsychiatric symptoms of Kleefstra syndrome, a rare genetic disorder characterized by childhood hypotonia, intellectual disability, distinctive facial features, and myriad psychiatric and behavioral disturbances. A 24-year-old female patient with childhood hypotonia, developmental delay, and diagnoses of autism spectrum disorder,

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