Academic literature on the topic 'Cordes, Margarethe'

This article explores the reasons for the recent surge of interest in exhibitions and displays featuring corals and coral reefs, as well as the challenges and opportunities involved in curating coral. I argue that, while it can be difficult to convey the complex natural characteristics of corals through displays of coral specimens in museums, exhibitions such as Coral: Something Rich and Strange (2013‐14), and artworks such as Christine and Margaret Wertheim’s Crochet Coral Reef (2005‐present) and Tamiko Thiel’s Unexpected Growth (2018‐19), can deepen a sense of wonder in exhibition visitors and foster experiences of connection between humans and marine invertebrates ‐ ultimately to encourage ‘response-ability’ to and for the natural world. I suggest that collaborative, cross-disciplinary modes of exhibition making ‐ such as displaying works of art alongside scientific or natural history specimens ‐ provides curators with opportunities to intensify the affective responses of audiences.

Abstract Some time after Christmas 1605, Agostino Agazzari (1578–1640) was asked to provide music for a pastoral drama, Eumelio; it was performed a month later during Carnival at the Jesuit-run Seminario Romano. In the preface to the subsequently published score (Venice: Amadino, 1606), Agazzari tells his readers that he agreed to the commission ‘because of the beautiful and useful allegory that I saw in [the libretto]’. What this beautiful and useful allegory was, however, has not been apparent to modern scholars. Margaret Johnson goes so far as to write that ‘It is perhaps unfortunate that Agazzari even mentioned the presence of a moral; it might otherwise have been overlooked, since its presence is obtrusive only in the composer’s preface’. This article offers an interpretation of the allegory of Eumelio by reading the opera as a commentary on the musical and spiritual teachings of Council of Trent, to which the printer’s mark of Agazzari’s publisher, Ricciardo Amadino, paratextually alludes. Although Amadino was the printer of some of the most famous prints of the Seicento (including Monteverdi’s Orfeo and Fifth Book of Madrigals), his printer’s mark and motto, ‘more with the heart than with the organ’, has not been commented upon in modern scholarship. The motto’s possible sources and its contemporary resonances and meanings point to an understanding of Eumelio as an allegory of Christian soteriology and the Christian musician. The opera externalizes and dramatizes the kinds of inner examination that many believed were incumbent on musicians in a post-Trent musico-religious culture. As a performed and printed work, then, Eumelio gave musicians pause to reflect on their inner lives, the purpose of their musical activities, and the kinds of motivations they acted upon in performance.

Cet article montre que les hommes des débuts de la modernité étaient plus près des liens radicaux d’Einstein entre le temps et l’espace, que les scientifiques modernes d’après Newton. L’écriture offrait aux hommes et aux femmes un accès à un espace imaginaire au-delà du temps chronologique, et ainsi, à des possibilités de renégocier leur position relative dans le cadre de ces limites très réelles. Dans un deuxième temps, on se penche sur la relativité de l’espace et du temps en tant que produits de pratiques sociales et historiques. On y discute donc de deux scènes de la pièce Richard III afin d’intervertir les perceptions courantes de la femme en tant que confinée à un espace intérieur, et de l’homme comme se mouvant plus librement dans l’espace-temps. On explore comment les pratiques spatiales des débuts de la modernité soulèvent de nouvelles questions au sujet des tropes pétrarquiens de l’emprisonnement et de la forme poétique. Dans un troisième temps, l’article examine les motifs de la porte et de la mémoire, considérant la mise en scène de la mort en tant que passage vers un ailleurs, dans la Duchesse de Malfi. La dernière partie de l’article met à profit les descriptions que fait Margaret Cavendish de plusieurs mondes au sein de celui-ci, afin d’émettre en conclusion des parallèles entre la littérature des débuts de la modernité et la théorie des cordes de la science actuelle.

114 Background: Crook et al have reported a 7-year disease-free survival (DFS) of 95.2% in 1,111 men with prostate cancer treated with Iodine-125 permanent seed brachytherapy (BT) at Princess Margaret Hospital. Two nomograms have been developed that estimate the likelihood of Gleason score (GS) upgrading for patients with favorable risk prostate cancer undergoing radical prostatectomy (RP). The purpose of this project was to apply these nomograms to a cohort treated with BT. Methods: Records were examined for all men receiving prostate BT in 2006-7. 217 had favorable risk disease. The likelihood of GS upgrading was predicted using RP-derived nomograms created by Kulkarni et al (PMH, 2007) and Budaus et al (2010). Clinical and pathologic information were available on 208 patients to allow completion of the Kulkarni nomogram, and on 193 patients for the Budaus nomogram. Results: The median age of the BT cohort was 62 years (range 44–77), and the median PSA level 4.68 ng/ml. Clinical stage was T1 in 65%, and 47.6% had positive findings on transrectal ultrasound. Median prostate volume was 33.3 cc (15.0–72.3). Uro-pathology review was available for 93%. 84.1% had extended biopsies, with 40.9% showing prostatic intraepithelial neoplasia and 10.1% inflammation. The median % of positive cores was 25%, with a median maximum % involvement per core of 20%. Two men received androgen deprivation therapy for prostate downsizing. The median predicted likelihood of GS upgrading was 51.6% using the Kulkarni nomogram, and 43.6% using the Budaus nomogram. The median PSA after 3.2 years median follow-up is 0.18 ng/mL. Conclusions: In a population of men with favorable risk prostate cancer treated with BT, the estimated likelihood of GS upgrading using two surgical nomograms was substantial. The study cohort was taken from a larger population of patients treated over 10 years for whom 7-year DFS is 95.2%. This suggests that permanent seed brachytherapy is a highly effective treatment option for patients with favorable risk disease despite unfavorable clinical and pathologic factors. Patients should not be discouraged from brachytherapy on the basis of a high likelihood of GS upgrading. No significant financial relationships to disclose.

TPS2679 Background: Immune checkpoint inhibitors (ICI) have demonstrated efficacy in a wide variety of cancers. Nevertheless, only a small proportion of patients derive a durable benefit. Mechanisms underlying primary and acquired resistance are still incompletely understood. They comprise tumor-intrinsic factors such as genomic and transcriptomic changes; upregulation of immunosuppressive subsets; T cell exhaustion; and promotion of an immune-tolerant tumor microenvironment. The collection of tumor biopsy at disease progression (PD) is challenging both in clinical and research settings as this often occurs at the time of treatment discontinuation. However, the analysis of these samples can lead to novel strategies to prevent or reverse immune resistance. Thus, the current approach to begin a profiling study with patients at the time of PD on ICI enables access and interrogation of such samples. Methods: IRIS is a prospective, investigator-initiated trial at the Princess Margaret Cancer Centre that aims to extensively characterize the genomic, transcriptomic, epigenetic and immunophenotypic profiles of tumors with primary versus acquired resistance to ICI-based therapy. Primary resistance is defined as PD at the first on-treatment imaging, whereas acquired resistance is defined as PD occurring after an initial partial or complete response or following disease stability lasting ≥6 months. Additional objectives include the evaluation of radiomic parameters on standard radiological imaging, investigation of fecal microbiome, generation of patient-derived organoids and facilitation of data and sample sharing with the research community. The planned samples size is 100 patients. A one-time fresh tumor biopsy, blood and stool samples and archival tissue (when available) are collected at the time of PD on ICI (baseline) from all the participants. Longitudinal blood samples are obtained every 2-3 months (around the time of tumor imaging) until PD in patients receiving a subsequent treatment. Subjects who are not amenable for therapy undergo blood collections at the time of further PD. Molecular characterization of tumor samples includes: DNA/RNA sequencing, Assay of Transposase Accessible Chromatin (ATAC)-sequencing, Cellular Indexing of Transcriptomes and Epitopes (CITE)-sequencing, multiplexed immunohistochemistry and flow cytometry. Results of NGS performed on the first biopsy core are returned to patient and physician. Key eligibility criteria include diagnosis of solid tumor, progression to ICI as the most recent line of treatment and disease amenable to core needle biopsy. The IRIS trial, activated in October 2020, is currently open to enrollment. As of January 2021, 21 patients have been enrolled and a total of 92 tissue cores, 42 blood and 20 stool samples have been collected. Clinical trial information: NCT04243720.

Abstract Background: Lymphomas often present a diagnostic challenge, leading to delays in obtaining a definitive diagnosis. For some lymphomas, a delay in diagnosis can negatively influence outcomes of therapy and result in a shorter duration of remission. Patients are often referred for evaluation with lymphoma diagnosis based on cytology from fine needle aspiration (FNA), whereas excisional or core lymph node biopsy is required for definitive diagnosis. We established a nurse practitioner-led Lymphoma Rapid Diagnostic Clinic (LRDC) with the goal of reducing wait times to diagnosis and initiation of treatment. Program development included surgical and interventional radiology engagement, and dedicated operating room time for excisional lymph node biopsies. We conducted a retrospective chart review to describe the initial 30-month experience of the LRDC. Results were compared to time periods before implementation of the clinic to determine program impact, and identify areas for quality improvement. Methods: All patients referred to LRDC at Princess Margaret Cancer Centre (PM), part of University Health Network (UHN), with suspicion of lymphoma from June 1, 2015 to Nov 30, 2017 were evaluated. Patients were excluded if they arrived in clinic with confirmed diagnosis of lymphoma or declined further LRDC evaluation. Patient symptoms and relevant laboratory/imaging findings were collected to identify patterns of presentation and predictive factors for benign diagnoses. Time from initial consultation to diagnosis and treatment were compared to patients diagnosed with lymphoma by surgical, medical, or oncology services at UHN in 2008 and 2012. Statistical significance was investigated using Fisher Exact test for categorical variables, and non-parametric Wilcoxon rank sum test for continuous data. Statistical significance level was chosen at a 2-sided p-value of 0.05 or less. Results: Of 129 patients referred to LRDC with suspected lymphoma, 126 were included in the analysis. Median age was 55yrs (range 18- 95yrs), and 67 patients (53%) were female. Thirty-nine patients had non-diagnostic FNA and/or core biopsies at initial assessment. Twenty-five had a prior cancer diagnosis, 30 presented with B symptoms and 57 had palpable enlarged lymph nodes (Table 1). To obtain a definitive diagnosis, 93 patients had biopsies (46 image-guided cores, 37 excisional, 6 FNA, 4 bone marrow); 13 patients received a diagnosis after pathology review, 4 via peripheral blood flow cytometry, and 16 following other clinical or serologic/imaging investigations. Following evaluation, 66 patients (52%) had confirmation of a diagnosis of lymphoma (34 indolent, 18 aggressive, 14 Hodgkin lymphoma (HL)), 2 had acute leukemia, 14 had metastatic cancer, and 44 had non-malignant diagnoses (Table 2). Median time from initial assessment to lymphoma diagnosis was 16 days (interquartile range 9-24 days) for the patients assessed in LRDC and 28 days (interquartile range 19-48 days) for historical controls (p <0.001). Median time from initial LRDC assessment to treatment for aggressive lymphomas and HL was 29 days (interquartile range 21-43 days) compared to 48 days (interquartile range 28-78 days) for historical controls (p= <0.001). The total number of biopsies obtained before diagnosis was significantly fewer for patients assessed in LRDC compared to historical controls (p<0.001, Fisher's exact test). By univariable analysis, lymph node size >3.4 cm and presence of mediastinal or abdominal adenopathy increased the likelihood of a diagnosis of malignancy, while younger age, being a non-smoker, and prior rheumatologic condition were associated with a non-malignant diagnosis. In multivariable analysis, lymph node size, age and prior rheumatologic diagnosis remained significant. Presence of B symptoms was not predictive. Conclusion: Establishing the nurse practitioner-led LRDC was effective in shortening time to diagnosis and treatment, and reduced the number of biopsies required for definitive diagnosis of lymphoma. Younger age, smaller lymph node size and prior rheumatologic disorder reduced the likelihood of a cancer diagnosis in our patient population. Disclosures Kuruvilla: Princess Margaret Cancer Foundation: Research Funding; Janssen: Consultancy, Honoraria, Research Funding; Abbvie: Consultancy; Lundbeck: Honoraria; Seattle Genetics: Consultancy, Honoraria; Gilead: Consultancy, Honoraria; Karyopharm: Honoraria; Roche: Consultancy, Honoraria, Research Funding; Leukemia and Lymphoma Society Canada: Research Funding; BMS: Consultancy, Honoraria; Celgene: Honoraria; Merck: Consultancy, Honoraria; Amgen: Honoraria.

Insects represent a relevant didactic resource to work with artistic skills, concepts, attitudes and values in the Science teaching because they are diversified in forms and colors, and because they have different life styles. However, there are relatively few reports of experience with evidence of their importance as a didactic resource. In this sense, our main aims were to describe and analyze: (1) the perceptions of seventh-year elementary school students of a public school in Uberlândia-MG, Brazil, about insects; and (2) a didactic sequence in which insects are used to work concepts, artistic skills, attitudes and values, such as respect for life. In 2018, we applied and analyzed 47 questionnaires with five questions about insects; and after we prepared a didactic sequence to stimulate student’s learning through strategies such as reading, dictionary use, research, expository lecture, and drawing. We noticed that most students knew at least one insect, although they had little information on insects’ scientific and ecological importance. We also noticed from the reports, participation, and evaluation of the students that the didactic sequence was useful on several competencies abovementioned, suggesting that the use of different types of strategies can stimulate students to become interested and participate actively in the classes. Therefore, insects represent an excellent didactic resource to work conceptual, procedural and attitudinal concepts in Science teaching.ResumoPor serem diversificados em formas e cores, e também por possuírem variados modos de vida, os insetos representam um relevante recurso didático para trabalhar com habilidades artísticas, conceitos, atitudes e valores no ensino de Ciências. Contudo, há relativamente poucos relatos de experiência com evidências da importância deles como recurso didático. Neste contexto, os principais objetivos deste relato foram descrever e analisar: (1) as percepções de estudantes do sétimo ano do Ensino Fundamental de uma escola pública de Uberlândia-MG quanto aos insetos; e (2) uma sequência didática em que os insetos são utilizados para trabalhar conceitos, habilidades artísticas, atitudes e valores, como o respeito à vida. Em 2018 foram aplicados e analisados, em uma perspectiva quali-quantitativa, 47 questionários com cinco questões sobre os insetos. Depois, foi desenvolvida uma sequência didática envolvendo leitura com uso de dicionário, pesquisa, aula expositiva dialogada, momento musical e confecção de desenhos. De maneira geral, os questionários evidenciaram que a maior parte dos estudantes foi capaz de reconhecer pelo menos um tipo de inseto, embora soubessem pouco sobre sua importância científica e ecológica. Notou-se também, pelos relatos, participação, avaliação dos estudantes e comportamento deles para com os insetos, que a sequência didática foi útil para trabalhar as diferentes competências acima mencionadas, o que sugere que o uso dos insetos junto com variados tipos de estratégias pode estimular os estudantes a se interessarem e participarem ativamente das aulas. Portanto, os insetos representaram um excelente recurso didático para trabalhar conteúdos conceituais, procedimentais e atitudinais no ensino de Ciências.ResumenPor ser diversificados en formas y colores, y también por sus variados modos de vida, los insectos representan un relevante recurso didáctico para trabajar con habilidades artísticas, conceptos, actitudes y valores en la enseñanza de las Ciencias. Sin embargo, hay relativamente pocos relatos de experiencia con evidencias de su importancia como recurso didáctico. En este contexto, los principales objetivos de este estudio fueron: (1) describir y analizar las percepciones de estudiantes del séptimo año de la Enseñanza Fundamental de una escuela pública de Uberlândia-MG en cuanto a los insectos; y (2) describir una secuencia didáctica en la que los insectos se utilizan para trabajar conceptos, habilidades artísticas, actitudes y valores, como el respeto a la vida. En el año 2018 se aplicaron y analizaron 47 cuestionarios con cinco preguntas sobre los insectos y luego se preparó y analizó una secuencia didáctica que involucra lectura con uso de diccionario, investigación, clase expositiva dialogada y confección de dibujos. En general, los cuestionarios evidenciaron que la mayor parte de los estudiantes fue capaz de reconocer al menos un tipo de insecto, aunque supieron poco sobre su importancia científica y ecológica. Se ha notado también, por los relatos, participación y evaluación de los estudiantes, que la secuencia didáctica ha sido útil para trabajar diferentes competencias, lo que sugiere que el uso de variados tipos de estrategias puede estimular a los estudiantes a interesarse y participar activamente en las clases. Por lo tanto, los insectos representan un excelente recurso didáctico para trabajar contenidos conceptuales, procedimentales y actitudinales en la enseñanza de las Ciencias.Palavras-chave: Ensino de Ciências, Insetos na educação básica, Metodologias ativas, Recurso didático.Keywords: Active methodologies, Didactic resource, Insects in elementary school, Science teaching.Palabras claves: Enseñanza de Ciencias, Insectos en la educación básica, Metodologías activas, Recurso didáctico.ReferencesALMEIDA-NETO, José Rodrigues; COSTA-NETO, Eraldo Medeiros; SILVA, Paulo Roberto Ramalho; BARROS, Roseli Faria Melo. 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Abstract The Society gratefully acknowledges the time and effort of the following individuals who served as reviewers of abstracts for this meeting: ASH ABSTRACTS COORDINATING REVIEWERS Blanche P. Alter Stephen M. Ansell Ralph B. Arlinghaus Scott Armstrong Asad Bashey Philip Bierman Neil Blumberg Chiara Bonini Dominique Bonnet Jacqueline Boultwood Rena Buckstein John C. Byrd Marc Carrier Lucio H. Castilla Selina Chen-Kiang Nicholas Chiorazzi Jorge Cortes-Franco Claire E. Dearden Mary C. Dinauer Harry Paul Erba Carolyn A. Felix Pierre Fenaux Debra L. Friedman Irene M. Ghobrial Jason R. Gotlib Brandon Hayes-Lattin Cheryl A. Hillery Achille Iolascon Jean-Pierre J. Issa Sundar Jagannath Diane F. Jelinek H. Phillip Koeffler John Koreth Robert J. Kreitman Robert B. Levy David Lillicrap Richard Lottenberg John D. McMannis Mark D. Minden Charles G. Mullighan Arnon Nagler Peter J. Newman Robert Z. Orlowski Antonio Palumbo Julie A. Panepinto Warren S. Pear Sibrand Poppema Barbara Pro Ching-Hon Pui A. Koneti Rao Aaron P. Rapoport Pieter H. Reitsma Douglas D. Ross J. Eric Russell Barbara Savoldo Kirk R. Schultz Radek C. Skoda Marilyn L. Slovak Susan Smyth Hugo ten Cate Herve Tilly John M. Timmerman Ivo Touw Amy J. Wagers Russell E. Ware Catherine J. Wu Virginia M. Zaleskas ASH ABSTRACTS REVIEWERS Camille Abboud Omar Abdel-Wahab Jeremy Abramson Suneet Agarwal Sikander Ailawadhi Onder Alpdogan Andrew Aprikyan Mary Armanios Aneel Ashrani Norio Asou Aglaia Athanassiadou Eyal Attar Mohammad Azam Maria Baer Jorg Baesecke Sarah Ball Karen Ballen Frederic Baron Shannon Bates Minoo Battiwalla Marie Bene Charles Bennett James Berenson Steven Bernstein Francesco Bertoni Monica Bessler Wolfgang Bethge Kapil Bhalla Deepa Bhojwani James Bieker Bruce R. Blazar Annemarie Block David Bodine Catherine Bollard Antonio Bonati Eric Bouhassira Benjamin Braun Christopher Bredeson Patrick Brown Ross Brown Jan Burger Dario Campana Jose Cancelas Paul Carpenter Andrew Carroll James Casella Rebecca Chan Roy Chemaly Benny Chen Jerry Cheng Linzhao Cheng Bruce Cheson Mark Chiang Athar Chishti Hearn Cho Magdalena Chrzanowska-Wodnicka Richard E. Clark Joseph Connors Kenneth Cooke Miguel Cruz Adam Cuker Sandeep Dave Janice Davis Sproul Lucia De Franceschi Philip De Groot Rodney DeKoter Richard Delarue Stephen Devereux Steven Devine Paola Jorge Di Don Diamond Meletios Dimopoulos John DiPersio Angela Dispenzieri Benjamin Djulbegovic Jing-fei Dong James Downing William Drobyski Rafael Duarte Charles Dumontet Kieron Dunleavy Brian Durie Dimitar Efremov Elizabeth Eklund Jonas Emsley Patricia Ernst Andrew Evens Chris Fegan Andrew Feldman Giuliana Ferrari Willem Fibbe Adele Fielding Thoas Fioretos Robert Flaumenhaft Rafael Fonseca James Foran Joseph Frank Janet Franklin Paul Frenette Alan Friedman Terry Fry Saghi Gaffari Naomi Galili Patrick Gallagher Anne Galy David Garcia Randy Gascoyne Cristina Gasparetto Norbert Gattermann Tobias Gedde-Dahl Alan Gewirtz Francis Giles Robert Godal Lucy Godley Ivana Gojo Norbert Gorin Andre Goy Eric Grabowski Steven Grant Timothy Graubert Elizabeth Griffiths H. Leighton Grimes Claudia Haferlach Corinne Haioun Parameswaran Hari Christine Harrison Robert Hasserjian Nyla Heerema Shelly Heimfeld Roland Herzog Elizabeth Hexner Teru Hideshima William H. Hildebrand Gerhard Hildebrandt Devendra Hiwase Karin Hoffmeister Donna Hogge Scott Howard Brian Huntly Hiroto Inaba Baba Inusa Shai Izraeli Suresh Jhanwar Amy Johnson Craig Jordan Joseph Jurcic Nina Kadan-Lottick Lawrence Kaplan Jonathan Kaufman Neil Kay Michelle Kelliher Craig Kessler H. 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Wijermans John Wingard Anne Woolfrey Mingjiang Xu Qing Yi Anas Younes Ryan Zarychanski Arthur Zelent Clive Zent Dong-Er Zhang Xianzheng Zhou James Zimring

IntroductionTasmania hangs from the map of Australia like a drop in freefall from the substance of the mainland. Often the whole state is mislaid from Australian maps and logos (Reddit). Tasmania has, at least since federation, been considered peripheral—a region seen as isolated, a ‘problem’ economically, politically, and culturally. However, Tasmania not only cleaves to the ‘north island’ of Australia but is also subject to the gravitational pull of an even greater land mass—Antarctica. In this article, we upturn the political conventions of map-making that place both Antarctica and Tasmania in obscure positions at the base of the globe. We show how a changing global climate re-frames Antarctica and the Southern Ocean as key drivers of worldwide environmental shifts. The liquid and solid water between Tasmania and Antarctica is revealed not as a homogenous barrier, but as a dynamic and relational medium linking the Tasmanian archipelago with Antarctica. When Antarctica becomes the focus, the script is flipped: Tasmania is no longer on the edge, but core to a network of gateways into the southern land. The state’s capital of Hobart can from this perspective be understood as an “Antarctic city”, central to the geopolitics, economy, and culture of the frozen continent (Salazar et al.). Viewed from the south, we argue, Tasmania is not a problem, but an opportunity for a form of ecological, cultural, economic, and political sustainability that opens up the southern continent to science, discovery, and imagination.A Centre at the End of the Earth? Tasmania as ParadoxThe islands of Tasmania owe their existence to climate change: a period of warming at the end of the last ice age melted the vast sheets of ice covering the polar regions, causing sea levels to rise by more than one hundred metres (Tasmanian Climate Change Office 8). Eleven thousand years ago, Aboriginal people would have witnessed the rise of what is now called Bass Strait, turning what had been a peninsula into an archipelago, with the large island of Tasmania at its heart. The heterogeneous practices and narratives of Tasmanian regional identity have been shaped by the geography of these islands, and their connection to the Southern Ocean and Antarctica. Regions, understood as “centres of collective consciousness and sociospatial identities” (Paasi 241) are constantly reproduced and reimagined through place-based social practices and communications over time. As we will show, diverse and contradictory narratives of Tasmanian regionality often co-exist, interacting in complex and sometimes complementary ways. Ecocritical literary scholar C.A. Cranston considers duality to be embedded in the textual construction of Tasmania, writing “it was hell, it was heaven, it was penal, it was paradise” (29). Tasmania is multiply polarised: it is both isolated and connected; close and far away; rich in resources and poor in capital; the socially conservative birthplace of radical green politics (Hay 60). The weather, as if sensing the fine balance of these paradoxes, blows hot and cold at a moment’s notice.Tasmania has wielded extraordinary political influence at times in its history—notably during the settlement of Melbourne in 1835 (Boyce), and during protests against damming the Franklin River in the early 1980s (Mercer). However, twentieth-century historical and political narratives of Tasmania portray the Bass Strait as a barrier, isolating Tasmanians from the mainland (Harwood 61). Sir Bede Callaghan, who headed one of a long line of federal government inquiries into “the Tasmanian problem” (Harwood 106), was clear that Tasmania was a victim of its own geography:the major disability facing the people of Tasmania (although some residents may consider it an advantage) is that Tasmania is an island. Separation from the mainland adversely affects the economy of the State and the general welfare of the people in many ways. (Callaghan 3)This perspective may stem from the fact that Tasmania has maintained the lowest Gross Domestic Product per capita of all states since federation (Bureau of Infrastructure Transport and Regional Economics 9). Socially, economically, and culturally, Tasmania consistently ranks among the worst regions of Australia. Statistical comparisons with other parts of Australia reveal the population’s high unemployment, low wages, poor educational outcomes, and bad health (West 31). The state’s remoteness and isolation from the mainland states and its reliance on federal income have contributed to the whole of Tasmania, including Hobart, being classified as ‘regional’ by the Australian government, in an attempt to promote immigration and economic growth (Department of Infrastructure and Regional Development 1). Tasmania is indeed both regional and remote. However, in this article we argue that, while regionality may be cast as a disadvantage, the island’s remote location is also an asset, particularly when viewed from a far southern perspective (Image 1).Image 1: Antarctica (Orthographic Projection). Image Credit: Wikimedia Commons, Modified Shading of Tasmania and Addition of Captions by H. Nielsen.Connecting Oceans/Collapsing DistanceTasmania and Antarctica have been closely linked in the past—the future archipelago formed a land bridge between Antarctica and northern land masses until the opening of the Tasman Seaway some 32 million years ago (Barker et al.). The far south was tangible to the Indigenous people of the island in the weather blowing in from the Southern Ocean, while the southern lights, or “nuyina”, formed a visible connection (Australia’s new icebreaker vessel is named RSV Nuyina in recognition of these links). In the contemporary Australian imagination, Tasmania tends to be defined by its marine boundaries, the sea around the islands represented as flat, empty space against which to highlight the topography of its landscape and the isolation of its position (Davies et al.). A more relational geographic perspective illuminates the “power of cross-currents and connections” (Stratford et al. 273) across these seascapes. The sea country of Tasmania is multiple and heterogeneous: the rough, shallow waters of the island-scattered Bass Strait flow into the Tasman Sea, where the continental shelf descends toward an abyssal plain studded with volcanic seamounts. To the south, the Southern Ocean provides nutrient-rich upwellings that attract fish and cetacean populations. Tasmania’s coast is a dynamic, liminal space, moving and changing in response to the global currents that are driven by the shifting, calving and melting ice shelves and sheets in Antarctica.Oceans have long been a medium of connection between Tasmania and Antarctica. In the early colonial period, when the seas were the major thoroughfares of the world and inland travel was treacherous and slow, Tasmania’s connection with the Southern Ocean made it a valuable hub for exploration and exploitation of the south. Between 1642 and 1900, early European explorers were followed by British penal colonists, convicts, sealers, and whalers (Kriwoken and Williamson 93). Tasmania was well known to polar explorers, with expeditions led by Jules Dumont d’Urville, James Clark Ross, Roald Amundsen, and Douglas Mawson all transiting through the port of Hobart. Now that the city is no longer a whaling hub, growing populations of cetaceans continue to migrate past the islands on their annual journeys from the tropics, across the Sub-Antarctic Front and Antarctic circumpolar current, and into the south polar region, while southern species such as leopard seals are occasionally seen around Tasmania (Tasmania Parks and Wildlife). Although the water surrounding Tasmania and Antarctica is at times homogenised as a ‘barrier’, rendering these places isolated, the bodies of water that surround both are in fact permeable, and regularly crossed by both humans and marine species. The waters are diverse in their physical characteristics, underlying topography, sea life, and relationships, and serve to connect many different ocean regions, ecosystems, and weather patterns.Views from the Far SouthWhen considered in terms of its relative proximity to Antarctic, rather than its distance from Australia’s political and economic centres, Tasmania’s identity undergoes a significant shift. A sign at Cockle Creek, in the state’s far south, reminds visitors that they are closer to Antarctica than to Cairns, invoking a discourse of connectedness that collapses the standard ten-day ship voyage to Australia’s closest Antarctic station into a unit comparable with the routinely scheduled 5.5 hour flight to North Queensland. Hobart is the logistical hub for the Australian Antarctic Division and the French Institut Polaire Francais (IPEV), and has hosted Antarctic vessels belonging to the USA, South Korea, and Japan in recent years. From a far southern perspective, Hobart is not a regional Australian capital but a global polar hub. This alters the city’s geographic imaginary not only in a latitudinal sense—from “top down” to “bottom up”—but also a longitudinal one. Via its southward connection to Antarctica, Hobart is also connected east and west to four other recognized gateways: Cape Town in South Africa, Christchurch in New Zealand; Punta Arenas in Chile; and Ushuaia in Argentina (Image 2). The latter cities are considered small by international standards, but play an outsized role in relation to Antarctica.Image 2: H. Nielsen with a Sign Announcing Distances between Antarctic ‘Gateway’ Cities and Antarctica, Ushuaia, Argentina, 2018. Image Credit: Nicki D'Souza.These five cities form what might be called—to adapt geographer Klaus Dodds’ term—a ‘Southern Rim’ around the South Polar region (Dodds Geopolitics). They exist in ambiguous relationship to each other. Although the five cities signed a Statement of Intent in 2009 committing them to collaboration, they continue to compete vigorously for northern hemisphere traffic and the brand identity of the most prominent global gateway. A state government brochure spruiks Hobart, for example, as the “perfect Antarctic Gateway” emphasising its uniqueness and “natural advantages” in this regard (Tasmanian Government, 2016). In practice, the cities are automatically differentiated by their geographic position with respect to Antarctica. Although the ‘ice continent’ is often conceived as one entity, it too has regions, in both scientific and geographical senses (Terauds and Lee; Antonello). Hobart provides access to parts of East Antarctica, where the Australian, French, Japanese, and Chinese programs (among others) have bases; Cape Town is a useful access point for Europeans going to Dronning Maud Land; Christchurch is closest to the Ross Sea region, site of the largest US base; and Punta Arenas and Ushuaia neighbour the Antarctic Peninsula, home to numerous bases as well as a thriving tourist industry.The Antarctic sector is important to the Tasmanian economy, contributing $186 million (AUD) in 2017/18 (Wells; Gutwein; Tasmanian Polar Network). Unsurprisingly, Tasmania’s gateway brand has been actively promoted, with the 2016 Australian Antarctic Strategy and 20 Year Action Plan foregrounding the need to “Build Tasmania’s status as the premier East Antarctic Gateway for science and operations” and the state government releasing a “Tasmanian Antarctic Gateway Strategy” in 2017. The Chinese Antarctic program has been a particular focus: a Memorandum of Understanding focussed on Australia and China’s Antarctic relations includes a “commitment to utilise Australia, including Tasmania, as an Antarctic ‘gateway’.” (Australian Antarctic Division). These efforts towards a closer relationship with China have more recently come under attack as part of a questioning of China’s interests in the region (without, it should be noted, a concomitant questioning of Australia’s own considerable interests) (Baker 9). In these exchanges, a global power and a state of Australia generally classed as regional and peripheral are brought into direct contact via the even more remote Antarctic region. This connection was particularly visible when Chinese President Xi Jinping travelled to Hobart in 2014, in a visit described as both “strategic” and “incongruous” (Burden). There can be differences in how this relationship is narrated to domestic and international audiences, with issues of sovereignty and international cooperation variously foregrounded, laying the ground for what Dodds terms “awkward Antarctic nationalism” (1).Territory and ConnectionsThe awkwardness comes to a head in Tasmania, where domestic and international views of connections with the far south collide. Australia claims sovereignty over almost 6 million km2 of the Antarctic continent—a claim that in area is “roughly the size of mainland Australia minus Queensland” (Bergin). This geopolitical context elevates the importance of a regional part of Australia: the claims to Antarctic territory (which are recognised only by four other claimant nations) are performed not only in Antarctic localities, where they are made visible “with paraphernalia such as maps, flags, and plaques” (Salazar 55), but also in Tasmania, particularly in Hobart and surrounds. A replica of Mawson’s Huts in central Hobart makes Australia’s historic territorial interests in Antarctica visible an urban setting, foregrounding the figure of Douglas Mawson, the well-known Australian scientist and explorer who led the expeditions that proclaimed Australia’s sovereignty in the region of the continent roughly to its south (Leane et al.). Tasmania is caught in a balancing act, as it fosters international Antarctic connections (such hosting vessels from other national programs), while also playing a key role in administering what is domestically referred to as the Australian Antarctic Territory. The rhetoric of protection can offer common ground: island studies scholar Godfrey Baldacchino notes that as island narratives have moved “away from the perspective of the ‘explorer-discoverer-colonist’” they have been replaced by “the perspective of the ‘custodian-steward-environmentalist’” (49), but reminds readers that a colonising disposition still lurks beneath the surface. It must be remembered that terms such as “stewardship” and “leadership” can undertake sovereignty labour (Dodds “Awkward”), and that Tasmania’s Antarctic connections can be mobilised for a range of purposes. When Environment Minister Greg Hunt proclaimed at a press conference that: “Hobart is the gateway to the Antarctic for the future” (26 Apr. 2016), the remark had meaning within discourses of both sovereignty and economics. Tasmania’s capital was leveraged as a way to position Australia as a leader in the Antarctic arena.From ‘Gateway’ to ‘Antarctic City’While discussion of Antarctic ‘Gateway’ Cities often focuses on the economic and logistical benefit of their Antarctic connections, Hobart’s “gateway” identity, like those of its counterparts, stretches well beyond this, encompassing geological, climatic, historical, political, cultural and scientific links. Even the southerly wind, according to cartoonist Jon Kudelka, “has penguins in it” (Image 3). Hobart residents feel a high level of connection to Antarctica. In 2018, a survey of 300 randomly selected residents of Greater Hobart was conducted under the umbrella of the “Antarctic Cities” Australian Research Council Linkage Project led by Assoc. Prof. Juan Francisco Salazar (and involving all three present authors). Fourteen percent of respondents reported having been involved in an economic activity related to Antarctica, and 36% had attended a cultural event about Antarctica. Connections between the southern continent and Hobart were recognised as important: 71.9% agreed that “people in my city can influence the cultural meanings that shape our relationship to Antarctica”, while 90% agreed or strongly agreed that Hobart should play a significant role as a custodian of Antarctica’s future, and 88.4% agreed or strongly agreed that: “How we treat Antarctica is a test of our approach to ecological sustainability.” Image 3: “The Southerly” Demonstrates How Weather Connects Hobart and Antarctica. Image Credit: Jon Kudelka, Reproduced with Permission.Hobart, like the other gateways, activates these connections in its conscious place-branding. The city is particularly strong as a centre of Antarctic research: signs at the cruise-ship terminal on the waterfront claim that “There are more Antarctic scientists based in Hobart […] than at any other one place on earth, making Hobart a globally significant contributor to our understanding of Antarctica and the Southern Ocean.” Researchers are based at the Institute for Marine and Antarctic Studies (IMAS), the Commonwealth Scientific and Industrial Research Organisation (CSIRO), and the Australian Antarctic Division (AAD), with several working between institutions. Many Antarctic researchers located elsewhere in the world also have a connection with the place through affiliations and collaborations, leading journalist Jo Chandler to assert that “the breadth and depth of Hobart’s knowledge of ice, water, and the life forms they nurture […] is arguably unrivalled anywhere in the world” (86).Hobart also plays a significant role in Antarctica’s governance, as the site of the secretariats for the Commission for the Conservation of Antarctic Marine Living Resources (CCAMLR) and the Agreement on the Conservation of Albatrosses and Petrels (ACAP), and as host of the Antarctic Consultative Treaty Meetings on more than one occasion (1986, 2012). The cultural domain is active, with Tasmanian Museum and Art Gallery (TMAG) featuring a permanent exhibit, “Islands to Ice”, emphasising the ocean as connecting the two places; the Mawson’s Huts Replica Museum aiming (among other things) to “highlight Hobart as the gateway to the Antarctic continent for the Asia Pacific region”; and a biennial Australian Antarctic Festival drawing over twenty thousand visitors, about a sixth of them from interstate or overseas (Hingley). Antarctic links are evident in the city’s natural and built environment: the dolerite columns of Mt Wellington, the statue of the Tasmanian Antarctic explorer Louis Bernacchi on the waterfront, and the wharfs that regularly accommodate icebreakers such as the Aurora Australis and the Astrolabe. Antarctica is figured as a southern neighbour; as historian Tom Griffiths puts it, Tasmanians “grow up with Antarctica breathing down their necks” (5). As an Antarctic City, Hobart mediates access to Antarctica both physically and in the cultural imaginary.Perhaps in recognition of the diverse ways in which a region or a city might be connected to Antarctica, researchers have recently been suggesting critical approaches to the ‘gateway’ label. C. Michael Hall points to a fuzziness in the way the term is applied, noting that it has drifted from its initial definition (drawn from economic geography) as denoting an access and supply point to a hinterland that produces a certain level of economic benefits. While Hall looks to keep the term robustly defined to avoid empty “local boosterism” (272–73), Gabriela Roldan aims to move the concept “beyond its function as an entry and exit door”, arguing that, among other things, the local community should be actively engaged in the Antarctic region (57). Leane, examining the representation of Hobart as a gateway in historical travel texts, concurs that “ingress and egress” are insufficient descriptors of Tasmania’s relationship with Antarctica, suggesting that at least discursively the island is positioned as “part of an Antarctic rim, itself sharing qualities of the polar region” (45). The ARC Linkage Project described above, supported by the Hobart City Council, the State Government and the University of Tasmania, as well as other national and international partners, aims to foster the idea of the Hobart and its counterparts as ‘Antarctic cities’ whose citizens act as custodians for the South Polar region, with a genuine concern for and investment in its future.Near and Far: Local Perspectives A changing climate may once again herald a shift in the identity of the Tasmanian islands. Recognition of the central role of Antarctica in regulating the global climate has generated scientific and political re-evaluation of the region. Antarctica is not only the planet’s largest heat sink but is the engine of global water currents and wind patterns that drive weather patterns and biodiversity across the world (Convey et al. 543). For example, Tas van Ommen’s research into Antarctic glaciology shows the tangible connection between increased snowfall in coastal East Antarctica and patterns of drought southwest Western Australia (van Ommen and Morgan). Hobart has become a global centre of marine and Antarctic science, bringing investment and development to the city. As the global climate heats up, Tasmania—thanks to its low latitude and southerly weather patterns—is one of the few regions in Australia likely to remain temperate. This is already leading to migration from the mainland that is impacting house prices and rental availability (Johnston; Landers 1). The region’s future is therefore closely entangled with its proximity to the far south. Salazar writes that “we cannot continue to think of Antarctica as the end of the Earth” (67). Shifting Antarctica into focus also brings Tasmania in from the margins. As an Antarctic city, Hobart assumes a privileged positioned on the global stage. This allows the city to present itself as central to international research efforts—in contrast to domestic views of the place as a small regional capital. The city inhabits dual identities; it is both on the periphery of Australian concerns and at the centre of Antarctic activity. Tasmania, then, is not in freefall, but rather at the forefront of a push to recognise Antarctica as entangled with its neighbours to the north.AcknowledgementsThis work was supported by the Australian Research Council under LP160100210.ReferencesAntonello, Alessandro. “Finding Place in Antarctica.” Antarctica and the Humanities. Eds. Peder Roberts, Lize-Marie van der Watt, and Adrian Howkins. London: Palgrave Macmillan, 2016. 181–204.Australian Government. 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Queen Margaret’s words ‘Make my image but an alehouse sign’ in 2 Henry VI (III. ii. 81) offer an appropriate metaphor for the female voice in Shakespeare’s texts because they advertise the ways female characters strive to speak out within a discursive environment that silences them as images. The chapter explores how women in Shakespeare’s plays negotiate a space to speak within a poetic discourse that repeatedly objectifies them as signs, focusing on Catherine’s role in Henry V and the blason, and the Jailer’s Daughter’s self-inscription into a ballad tradition in Two Noble Kinsmen. A second section uses the analytic tools provided by corpus-linguistics to explore the poetic voices of tragic female characters: Lady Macbeth, Cleopatra, and the women of Richard III. The essay concludes by tracing the growth of an independent, poetic female voice in the role of Queen Margaret who offers an ironic commentary on Shakespeare's growing sense of his own identity as national bard.

Margaret Cavendish, a seventeenth-century philosopher, scientist, poet, playwright, and novelist, went to battle with the great thinkers of her time, and in many cases arguably got the better of them, but she did not have the platform that she would have had in the twenty-first century. She took a creative and systematic stand on the major questions of philosophy of mind, epistemology, metaphysics, and political philosophy. She defends a number of theses across her corpus: for example, that human beings and all other members of the created universe are wholly material; that matter is eternal; that the universe is a plenum of contiguous bodies; that matter is generally speaking knowledgeable and perceptive and that non-human creatures like spiders, plants, and cells exhibit wisdom and skill; that motion is never transferred from one body to another, but bodies always move by motions that are internal to them; that sensory perception is not via impressions or stamping; that we can have no ideas of immaterials; and that creatures depend for their properties and features on the behavior of the beings that surround them. Cavendish uses her fictional work to further illustrate these views, and in particular to illustrate the view that creatures depend on their surroundings for their social and political properties. For example, she crafts alternative worlds in which women are not seen as unfit for roles such as philosopher, scientist, and military general, and in which they flourish. This volume of Cavendish’s writings provides a cross-section of her interconnected writings, views, and arguments.

This chapter argues that Margaret Cavendish is a libertarian with respect to the freedom of natural individuals. It takes account of the passages within Cavendish’s corpus that seem to imply she is a determinist and compatibilist, by examining debates about freedom and determinism current in her time, and by tracing the development of Cavendish’s views on this topic. This chapter also grapples with the claim that Cavendish lauded libertarian freedom in the political realm, which causes significant difficulties for the idea that she is a Royalist, ultimately rejecting this interpretation by focusing on Cavendish’s interests in the human’s inappropriate drive for fame.

The 6th Criminal Law Reform Act of 1998 increased the sentences for carrying ‘dangerous implements’ in the German Criminal Code, but attempts to give a sufficiently precise definition of the concept of a ‘dangerous implement’ have failed. However, there are hardly any considerations on how to draft an ‘appropriate new version of the law’, as suggested by the Federal Court of Justice (Bundesgerichtshof). This anthology documents a research project that compares the regulatory models of nine countries and aims to amend the law appropriately. A legal and historical representation of theft using weapons supplements the reports on each country. The comparative cross section summarises and evaluates the distinct models, and considerations for reform complete the anthology. Its publisher holds the Chair of Criminal Law, in particular European Criminal Law and International Criminal Law, at the European University Viadrina in Frankfurt (Oder), and focuses on comparative criminal law in her research. With contributions by Isidoro Blanco Cordero, Andreas Eicker, Margareth Helfer, Gudrun Hochmayr, Johannes Keiler, Aleksandra Ligocka, Maciej Małolepszy, Wolfgang Schild, Kurt Schmoller, Zsolt Szomora, Stephen Thaman

Interest in Margaret Cavendish’s philosophical views has increased dramatically in the past two decades. While earlier readers were not kind to Cavendish, recent scholarly work has been more sympathetic, showing how her writings were informed by the work of her contemporaries and revealing ways in which Cavendish’s views were original. Her corpus contains recurring themes, including a consistent interest in questions of gender, an obsession with fame, and a focus on the need for peace and order. This book argues that focusing on peace and order illuminates multiple facets of Cavendish’s philosophical thinking: her natural philosophy, her political theory, her views on gender, her views about the relationship between humans and the natural world, and her medical theory. This introductory chapter surveys some of the many texts in which Cavendish focuses on peace, order, and what she calls “regularity” and provides a summary of the topics addressed in subsequent chapters.

There are more than 15 million people over age 65 currently living in the Arab world, yet little attention has been paid to the cultural significance of growing old. The book recognizes the widespread silence by countering the critical corpus that reads the modern Arabic novel as a political discourse with an emphasis on youth achievement. By offering close readings of 16 fictional works from different parts of the Arab world such as novels by Alia Mamdouh, Sahar Khalifah, Iman Kachachi, Rashid al-Daif and Alaa al-Aswany, the study utilizes biological and cultural theories of ageing- particularly from the perspective of gender and feminism- that shed light on the representation of ageing in the Arabic novel. The study makes use of feminist theories of ageing and gerontology that focus on sexism and ageism, including works by Simone de Beauvoir and Margaret Marganroth Gullette to present aging as a relational formation between men and women, and their idiosyncratic experiences of the process of ageing, revealing that there is no prototype of oldness in the Arabic novel and that older men and women manifest a multiplicity of identities, concerns and experiences. The study challenges the ungendered image generally attributed to older persons and examines how they navigate old age and subvert it. As they grow older men and women manifest a multiplicity of identities, concerns, and experiences revealing that the ageing process is an ongoing inherently unstable project.