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Journal articles on the topic 'Cordycepts sinensis'

Author: Grafiati

Published: 8 September 2021

Last updated: 29 July 2025

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1

Kondapalli, Vamsi Krishna, and Alok Malaviya. "Comparison of cultivated Cordyceps militaris and wild Ophiocordyceps sinensis using high-performance thin-layer chromatography." Research Journal of Biotechnology 19, no. 12 (2024): 163–70. https://doi.org/10.25303/1912rjbt1630170.

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Cordyceps, a fungus from the ‘Clavicipitaceae’ family, has long been utilised in traditional Chinese medicine as a rare and prized mushroom. Among 750 known species, two noteworthy species within the genus are Ophiocordyceps sinensis and Cordyceps militaris. Among the active components generated by this genus, cordycepin and adenosine are particularly significant and exhibit various pharmacological properties. To evaluate and compare the concentrations of cordycepin and adenosine, high-performance thin-layer chromatography profiling was employed on lab-grown C. militaris and wild O. sinensis.

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2

Zhou, Xiaoxia, Liping Luo, Waike Dressel, et al. "Cordycepin is an Immunoregulatory Active Ingredient of Cordyceps sinensis." American Journal of Chinese Medicine 36, no. 05 (2008): 967–80. http://dx.doi.org/10.1142/s0192415x08006387.

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We have reported that cordycepin, an adenosine derivative from the fungus Cordyceps, increased interleukin (IL)-10 expression, decreased IL-2 expression and suppressed T lymphocyte activity. In the present study, we further characterized the regulatory effects of cordycepin on human immune cells. Moreover, a traditional Chinese drug, Cordyceps sinensis (CS) that contains cordycepin, was also investigated. Cytometric Bead Array (CBA) was used to determine the concentrations of IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, TNF-α and IFN-γ in culture of peripheral blood mononuclear cells (PB

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3

Zhang, Hong, Hong Mei Zhang, Li Han, and Sheng Hou Wang. "Cultivation Technique of Selenium-Enriched Cordyceps militaris." Applied Mechanics and Materials 522-524 (February 2014): 1147–50. http://dx.doi.org/10.4028/www.scientific.net/amm.522-524.1147.

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Cordyceps militaris has similar chemical composition, nutrition value, and medicinal functions as Cordyceps sinensis. However, its main medical composition such as cordycepin is much higher than that of the wild C. sinensis species. In addition, it is easier to cultivate artificially than C. sinensis. Thus, C. militaris is chosen as the best substitution for C. sinensis. This paper introduces the pharmacological effects of C. militaris and the effect of selenium on human body. It also summarizes ways of improving the content of selenium in artificially cultivated C. militaris and the optimal c

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4

Nguyen, Trai Ngoc, Nam Quoc Phan, SaNa Que Son, and Dang Thi Thao Tran. "INVESTIGATION ON FRUITING BODY OF CORDYCEPS MILITARIS CULTIVATION IN TRA VINH." Scientific Journal of Tra Vinh University 1, no. 27 (2019): 95–103. http://dx.doi.org/10.35382/18594816.1.27.2017.134.

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Cordyceps sinensis has traditionally been used in traditional Chinese medicine. However, C. sinensis has very low mass production and only grows in natural environment, whereas the fruiting bodies of Cordyceps militaris can be successfully farmed in cereals. C. militaris contains similar biochemical components as C. sinensis as well as the anticancer component cordycepin. This study is to investigate the effect of temperature, light intensity, milling of silkworm pupae supplemented with brown rice medium and silkworm pupae age on fruiting bodies of C. militaris. The optimal temperature for the

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5

Han, Feng, Meng Dou, Yuxiang Wang, et al. "Cordycepin protects renal ischemia/reperfusion injury through regulating inflammation, apoptosis, and oxidative stress." Acta Biochimica et Biophysica Sinica 52, no. 2 (2020): 125–32. http://dx.doi.org/10.1093/abbs/gmz145.

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Abstract Cordycepin (3′-deoxyadenosine) is a naturally occurring adenosine analog and one of the bioactive constituents isolated from Cordyceps sinensis, species of the fungal genus Cordyceps. It has traditionally been a prized Chinese folk medicine for the human well-being. However, the actions of cordycepin against renal ischemia/reperfusion injury (I/R) are still unknown. In the present study, rats were subject to I/R and cordycepin was intragastrically administered for seven consecutive days before surgery to investigate the effects and mechanisms of cordycepin against renal I/R injury. Th

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Tran, M. H., T. M. Nguyen, and V. B. Huynh. "Diversity evaluation of Cordyceps spp. in Bidoup Nui Ba, Lam Dong province, Vietnam." IOP Conference Series: Earth and Environmental Science 1155, no. 1 (2023): 012003. http://dx.doi.org/10.1088/1755-1315/1155/1/012003.

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Abstract Cordyceps have been known for various functional and valuable human health components such as: cordycepin, adenosine, and hydroxyethyl adenosine which led to high demand for their usage. There were more than 680 species of Cordyceps in the world. However, Cordyceps sinensis and Cordyceps militaris were the two most studied species, by these results, created pressure to look for other species that have at least similar functions or even better than Cordyceps sinensis and Cordyceps militaris. With that objective, diversity understanding was the initial step implemented. 20 specimens of

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7

Chen, Liping, Xiao Liu, Kaiyue Zheng, et al. "Cordyceps Polysaccharides: A Review of Their Immunomodulatory Effects." Molecules 29, no. 21 (2024): 5107. http://dx.doi.org/10.3390/molecules29215107.

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Cordyceps primarily consists of ascomycetes, a parasitic fungus that infects insects and arthropods. Recently, Cordyceps has been shown to manifest a diverse range of pharmacological activities, rendering it applicable for the treatment and mitigation of various diseases, such as diabetes, acute liver injury, and colitis. Many active constituents have been identified from Cordyceps sinensis, including cordycepin, adenosine, sterols, and polysaccharides. Polysaccharides constitute a primary active component of Cordyceps, exhibiting immunomodulatory effects. We searched the Web of Science databa

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8

Le Thi, Tuoi, Hue Le Thi, Kiet Cao Tuan та ін. "Effect of coordination nutritional ingredients on the development and cordycepin, adenosin production of Cordyceps militaris ĐÁNH GIÁ HIỆU QUẢ BỔ SUNG MỘT SỐ NGUỒN NITƠ VÀ CARBON VÀO MÔI TRƢỜNG NUÔI CẤY ĐẾN SỰ PHÁT TRIỂN VÀ KHẢ NĂNG TÍCH LUỸ HOẠT CHẤT CỦA NẤM ĐÔNG TRÙNG HẠ THẢO Cordyceps militaris". Journal of Science Natural Science 66, № 4F (2021): 82–91. http://dx.doi.org/10.18173/2354-1059.2021-0071.

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Cordyceps militaris is an insect parasitic fungus with high medicinal value similar to Cordyceps sinensis and has great economic value. Ensuring the balance between the biomass and the bioactive potential of C. militaris plays an important role in the development of quality products from this medicinal fungus. In this study, nitrogen sources (fresh silkworm pupae, peptone, yeast extract) with different concentrations were used to evaluate the effect on yield, morphology and content of cordycepin, adenosine of C. militaris. The results showed that the N1 medium using 20 g\L fresh silkworm pupae

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9

Miguel, A. Fernandez, Maris Mande Divina, Ventura Angel, Jommel De Leon Albert, and C. Estorico Gecelene. "Cordyceps sinensis: A Comprehensive Meta-Analysis of its Potential Health Benefits." International Journal of Innovative Science and Research Technology (IJISRT) 9, no. 11 (2024): 2195–202. https://doi.org/10.5281/zenodo.14329247.

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Cordyceps sinensis, a revered traditional Chinese medicine, has garnered significant attention for its diverse pharmacological properties. This comprehensive review delves into its potential health benefits, focusing on its bioactive compounds, clinical efficacy, and underlying mechanisms of action. Key  findings reveal its anti-cancer properties, including anti- proliferative, anti-metastatic, and immune-boosting  effects against various cancer cell lines. Additionally, its anti-inflammatory properties are evident in its ability to suppress inflammation by regulating key signaling p

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10

Miguel, A. Fernandez, Maris Mande Divina, Ventura Angel, Jommel De Leon Albert, and C. Estorico Gecelene. "Cordyceps sinensis: A Comprehensive Meta-Analysis of its Potential Health Benefits." International Journal of Innovative Science and Research Technology (IJISRT) 9, no. 11 (2024): 2195–202. https://doi.org/10.5281/zenodo.14329558.

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Cordyceps sinensis, a revered traditional Chinese medicine, has garnered significant attention for its diverse pharmacological properties. This comprehensive review delves into its potential health benefits, focusing on its bioactive compounds, clinical efficacy, and underlying mechanisms of action. Key  findings reveal its anti-cancer properties, including anti- proliferative, anti-metastatic, and immune-boosting  effects against various cancer cell lines. Additionally, its anti-inflammatory properties are evident in its ability to suppress inflammation by regulating key signaling p

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11

Özenver, Nadire, Joelle C. Boulos, and Thomas Efferth. "Activity of Cordycepin From Cordyceps sinensis Against Drug-Resistant Tumor Cells as Determined by Gene Expression and Drug Sensitivity Profiling." Natural Product Communications 16, no. 2 (2021): 1934578X2199335. http://dx.doi.org/10.1177/1934578x21993350.

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Cordycepin is one of the substantial components of the parasitic fungus Cordyceps sinensis as well as other Cordyceps species. It exerts various effects such as antimetastatic, antiinflammatory, antioxidant, and neuroprotective activities. Assorted studies revealed in vitro and in vivo anticancer influence of cordycepin and put forward its potential for cancer therapy. However, the role of multidrug resistance-associated mechanisms for the antitumor effect of cordycepin has not been investigated in great detail thus far. Therefore, we searched cordycepin’s cytotoxicity with regard to well-know

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12

Wai, Linn Aung, and Kyaw Moe. "Identification and Determination of Secondary Metabolites and Amino Acids in Cordyceps." Partners Universal International Innovation Journal (PUIIJ) 01, no. 04 (2023): 251–58. https://doi.org/10.5281/zenodo.8282693.

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The Cordyceps are used around the world due to its high medical and pharmaceutical value. Advanced biotechnology has revealed that Cordyceps sinensis has a wide range of secondary metabolites and amino acids. The secondary metabolites and amino acids are very important for the prevention and cure of diseases in human. The purpose of this study was to identify and determine of secondary metabolites and amino acids in Cordyceps. The secondary metabolites were qualitatively determined by gas chromatography mass spectrometer (GCMS). And then, the amino acids were determined by high performance liq

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13

Chen, Yu-Ying, Chun-Hsien Chen, Wei-Chen Lin, et al. "The Role of Autophagy in Anti-Cancer and Health Promoting Effects of Cordycepin." Molecules 26, no. 16 (2021): 4954. http://dx.doi.org/10.3390/molecules26164954.

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Cordycepin is an adenosine derivative isolated from Cordyceps sinensis, which has been used as an herbal complementary and alternative medicine with various biological activities. The general anti-cancer mechanisms of cordycepin are regulated by the adenosine A3 receptor, epidermal growth factor receptor (EGFR), mitogen-activated protein kinases (MAPKs), and glycogen synthase kinase (GSK)-3β, leading to cell cycle arrest or apoptosis. Notably, cordycepin also induces autophagy to trigger cell death, inhibits tumor metastasis, and modulates the immune system. Since the dysregulation of autophag

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14

Karmańska, Aleksandra, and Bolesław Karwowski. "Bioactive components of Cordyceps sinensis." Farmacja Polska 78, no. 7 (2022): 361–71. http://dx.doi.org/10.32383/farmpol/153911.

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15

Xiao, Mengjun, Tao Wang, Chuyu Tang, Min He, Yuling Li, and Xiuzhang Li. "Effects of Drying Methods on Morphological Characteristics, Metabolite Content, and Antioxidant Capacity of Cordyceps sinensis." Foods 13, no. 11 (2024): 1639. http://dx.doi.org/10.3390/foods13111639.

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Cordyceps sinensis is a rare and endangered medicinal herb in China and a typical medicinal and food plant. Most of the research related to Cordyceps sinensis focuses on its pharmacological effects, artificial cultivation and clinical applications. However, there are few comprehensive evaluations on the quality of Cordyceps sinensis under different drying methods. In this study, the effects of vacuum freeze-drying (DG), oven-drying (HG) and air-drying (YG) on the morphological characteristics, microstructure, antioxidant activity and metabolites of Cordyceps sinensis were investigated using wi

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16

Tung, Kuo-Lung, Su-Zhen Wu, Chun-Chuan Yang, et al. "Cordycepin Induces Apoptosis through JNK-Mediated Caspase Activation in Human OEC-M1 Oral Cancer Cells." Evidence-Based Complementary and Alternative Medicine 2022 (October 3, 2022): 1–10. http://dx.doi.org/10.1155/2022/1842363.

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Cordycepin, a bioactive compound extracted from Cordyceps sinensis, can induce apoptosis in human OEC-M1 oral cancer cells. However, the exact mechanism is still unclear. The present study aimed to investigate the underlying mechanism of cordycepin-induced apoptosis in OEC-M1 cells. Following treatment with cordycepin, apoptosis was examined and quantified using a DNA laddering assay and a cytokeratin 18 fragment enzyme-linked immunosorbent assay, respectively. Expressions of mitogen-activated protein kinases (MAPKs) and apoptosis-related proteins were detected by the western blot analysis. Ou

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17

Solakov, Nikolay, Milena Kostova, Kamelia Loginovska, Zlati Markov, Ana Caroline de Oliveira, and Yordan Muhovski. "Investigation of Adenosine Precursors and Biologically Active Peptides in Cultured Fresh Mycelium of Wild Medicinal Mushrooms." Applied Sciences 12, no. 20 (2022): 10618. http://dx.doi.org/10.3390/app122010618.

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Adenosine, known as an endogenous neuroprotective agent and acting as a cytoprotective modulator in organisms, is the subject of considerable scientific interest. Medicinal mushrooms represent a good source of bioactive compounds due to their composition and potent adaptogenic action, affecting more than 300 biochemical processes and functions in organisms. The aim of the present study was to investigate adenosine precursors and biologically active peptides in cultured fresh mycelium with focus on Ganoderma lucidum (Reishi) and Cordyceps sinensis as best studied species. Biologically active ex

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18

Wang, Di, Yongfeng Zhang, Jiahui Lu, et al. "Cordycepin, a Natural Antineoplastic Agent, Induces Apoptosis of Breast Cancer Cells via Caspase-dependent Pathways." Natural Product Communications 11, no. 1 (2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100119.

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Cordycepin, a major compound separated from Cordyceps sinensis, is known as a potential novel candidate for cancer therapy. Breast cancer, the most typical cancer diagnosed among women, remains a global health problem. In this study, the anti-breast cancer property of cordycepin and its underlying mechanisms was investigated. The direct effects of cordycepin on breast cancer cells both in in vitro and in vivo experiments were evaluated. Cordycepin exerted cytotoxicity in MCF-7 and MDA-MB-231 cells confirmed by reduced cell viability, inhibition of cell proliferation, enhanced lactate dehydroge

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19

Singh, Mrinalini, Rajkumar Tulsawani, Praveen Koganti, Amitabh Chauhan, Manimaran Manickam, and Kshipra Misra. "Cordyceps sinensisIncreases Hypoxia Tolerance by Inducing Heme Oxygenase-1 and Metallothionein via Nrf2 Activation in Human Lung Epithelial Cells." BioMed Research International 2013 (2013): 1–13. http://dx.doi.org/10.1155/2013/569206.

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Cordyceps sinensis, an edible mushroom growing in Himalayan regions, is widely recognized in traditional system of medicine. In the present study, we report the efficacy ofCordyceps sinensisin facilitating tolerance to hypoxia using A549 cell line as a model system. Treatment with aqueous extract ofCordyceps sinensisappreciably attenuated hypoxia induced ROS generation, oxidation of lipids and proteins and maintained antioxidant status similar to that of controls via induction of antioxidant gene HO1 (heme oxygenase-1), MT (metallothionein) and Nrf2 (nuclear factor erythroid-derived 2-like 2).

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20

Hu, Zhenzhen, Chung-Il Lee, Vikash Kumar Shah, et al. "Cordycepin Increases Nonrapid Eye Movement Sleep via Adenosine Receptors in Rats." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/840134.

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Cordycepin (3′-deoxyadenosine) is a naturally occurring adenosine analogue and one of the bioactive constituents isolated fromCordyceps militaris/Cordyceps sinensis, species of the fungal genusCordyceps. It has traditionally been a prized Chinese folk medicine for the human well-being. Because of similarity of chemical structure of adenosine, cordycepin has been focused on the diverse effects of the central nervous systems (CNSs), like sleep regulation. Therefore, this study was undertaken to know whether cordycepin increases the natural sleep in rats, and its effect is mediated by adenosine r

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21

Liu, Yi, Jihui Wang, Wei Wang, Hanyue Zhang, Xuelan Zhang, and Chunchao Han. "The Chemical Constituents and Pharmacological Actions ofCordyceps sinensis." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–12. http://dx.doi.org/10.1155/2015/575063.

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Cordyceps sinensis, also called DongChongXiaCao (winter worm, summer grass) in Chinese, is becoming increasingly popular and important in the public and scientific communities. This study summarizes the chemical constituents and their corresponding pharmacological actions ofCordyceps sinensis. Many bioactive components ofCordyceps sinensishave been extracted including nucleoside, polysaccharide, sterol, protein, amino acid, and polypeptide. In addition, these constituents’ corresponding pharmacological actions were also shown in the study such as anti-inflammatory, antioxidant, antitumour, ant

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22

Zhu, Zhen-Yuan, Meng Meng, Huiqing Sun, Yang Li, Na Yu, and Yong-Min Zhang. "Structural analysis and immunostimulatory activity of glycopeptides from Paecilomyces sinensis." Food & Function 7, no. 3 (2016): 1593–600. http://dx.doi.org/10.1039/c6fo00089d.

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23

Xiao, Mengjun, Tao Wang, Chuyu Tang, Min He, Yuling Li, and Xiuzhang Li. "Evaluation of Lipid Changes During the Drying Process of Cordyceps sinensis by Ultra Performance Liquid Chromatography–Tandem Mass Spectrometry (UPLC-MS/MS)-Based Lipidomics Technique." Journal of Fungi 10, no. 12 (2024): 855. https://doi.org/10.3390/jof10120855.

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Comprehensive analysis of the lipid content in Cordyceps sinensis samples is essential for optimizing their effective use. Understanding the lipid profile can significantly enhance the application of this valuable fungus across various fields, including nutrition and medicine. However, to date, there is limited knowledge regarding the effects of different drying methods on the quality of lipids present in Cordyceps sinensis. In this study, we employed a broadly targeted lipidomic strategy to conduct a comprehensive analysis of the lipid composition in Cordyceps sinensis subjected to various dr

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24

Chang, Ming-Min, Siou-Ying Hong, Shang-Hsun Yang, Chia-Ching Wu, Chia-Yih Wang, and Bu-Miin Huang. "Anti-Cancer Effect of Cordycepin on FGF9-Induced Testicular Tumorigenesis." International Journal of Molecular Sciences 21, no. 21 (2020): 8336. http://dx.doi.org/10.3390/ijms21218336.

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Cordycepin, a bioactive constituent from the fungus Cordyceps sinensis, could inhibit cancer cell proliferation and promote cell death via induction of cell cycle arrest, apoptosis and autophagy. Our novel finding from microarray analysis of cordycepin-treated MA-10 mouse Leydig tumor cells is that cordycepin down-regulated the mRNA levels of FGF9, FGF18, FGFR2 and FGFR3 genes in MA-10 cells. Meanwhile, the IPA-MAP pathway prediction result showed that cordycepin inhibited MA-10 cell proliferation by suppressing FGFs/FGFRs pathways. The in vitro study further revealed that cordycepin decreased

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25

Kubo, Erika, Ayuko Sato, Noriko Yoshikawa, Satomi Kagota, Kazumasa Shinozuka, and Kazuki Nakamura. "Effect of Cordyceps sinensis on TIMP-1 secretion from mouse melanoma cell." Open Life Sciences 7, no. 1 (2012): 167–71. http://dx.doi.org/10.2478/s11535-011-0094-9.

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AbstractCordyceps sinensis is a Chinese medicinal fungus traditionally used in cancer treatments. In a previous study, we investigated the antimetastatic activity of Cordyceps sinensis (WECS) extract using liver metastatic model mice injected with B16-F0 mouse melanoma cells into the spleen. WECS reduced the number of metastatic nodules of B16-F0 cells in the liver of C57BL/6 mice, and significantly prolonged survival of the mice. Furthermore, we examined the effects of WECS on hepatocyte growth factor (HGF)-accelerated invasion of B16-F0 cells using a chemo-invasion assay in vitro. WECS was s

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26

Winkler, Daniel. "CORDYCEPS SINENSIS." Field Mycology 11, no. 2 (2010): 60–67. http://dx.doi.org/10.1016/j.fldmyc.2010.04.009.

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27

Minakshi, Memoria, Kumar Shah Sanjeev, Anandaram Harishchander, et al. "An internet of things enabled framework to monitor the lifecycle of Cordyceps sinensis mushrooms." International Journal of Electrical and Computer Engineering (IJECE) 13, no. 1 (2023): 1142–51. https://doi.org/10.11591/ijece.v13i1.pp1142-1151.

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Cordyceps sinensis is an edible mushroom found in high quantities in the regions of the Himalayas and widely considered in traditional systems of medicine. It is a non-toxic remedy mushroom and has a high measure of clinical medical benefits including cancer restraint, high blood pressure, diabetes, asthma, depression, fatigue, immune disorder, and many infections of the upper respiratory tract. The cultivation of this kind of mushroom is limited to the region of the Sikkim and to cultivate in the other regions of the country, they are need of investigation and prediction of cordyceps sinensis

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Wang, Wei Yue, Wen Xian Sun, Guang Da Peng, Li Yi Dai, Li Hua Liu, and Bing Li. "Effect of Aqueous Extracts of Cultured Cordyceps militaris on Bombyx mori Ovary Cell Lines." Advanced Materials Research 356-360 (October 2011): 271–76. http://dx.doi.org/10.4028/www.scientific.net/amr.356-360.271.

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The caterpillar-shaped Chinese medicinal mushroom cordyceps sinensis has been used in China as a food or herbal medicine to treat numerous diseases. As uncultivated cordyceps sinensis is becoming extremely rare, the price of this herbal medicine is very high. In order to study the pharmacological effects and to minimize the cost, an economical method for culturing of cordyceps sinensis has been developed, which could be processed to large-scale production. We compared the pharmacological components, and the apoptosis inducing activity in BmN cells with both cultured and uncultivated cordyceps

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Chen, Li-hua, Yao Wu, Yong-mei Guan, Chen Jin, Wei-feng Zhu, and Ming Yang. "Analysis of the High-Performance Liquid Chromatography Fingerprints and Quantitative Analysis of Multicomponents by Single Marker of Products of Fermented Cordyceps sinensis." Journal of Analytical Methods in Chemistry 2018 (2018): 1–9. http://dx.doi.org/10.1155/2018/5943914.

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Fermented Cordyceps sinensis, the succedaneum of Cordyceps sinensis which is extracted and separated from Cordyceps sinensis by artificial fermentation, is commonly used in eastern Asia in clinical treatments due to its health benefit. In this paper, a new strategy for differentiating and comprehensively evaluating the quality of products of fermented Cordyceps sinensis has been established, based on high-performance liquid chromatography (HPLC) fingerprint analysis combined with similar analysis (SA), hierarchical cluster analysis (HCA), and the quantitative analysis of multicomponents by sin

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Ma, Jing, Zhenjiang Chen, Kamran Malik, and Chunjie Li. "Comparative Metabolite Profiling Between Cordyceps sinensis and Other Cordyceps by Untargeted UHPLC-MS/MS." Biology 14, no. 2 (2025): 118. https://doi.org/10.3390/biology14020118.

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Cordyceps sinensis is a second-class, nationally protected, medicinal fungi and serves as a functional nutrient in China. C. sinensis is extremely scarce due to its peculiar growing environment and the extensive gathering practices carried out by humans. A large number of counterfeit products for this fungi have also emerged in the market. At present, there is a lack of research on the differential metabolites of C. sinensis and its counterfeit products. The current study used an LC-MS non-targeted metabolomics method to compare the differences in metabolites between C. sinensis and other Cord

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31

Memoria, Minakshi, Sanjeev Kumar Shah, Harishchander Anandaram, et al. "An internet of things enabled framework to monitor the lifecycle of Cordyceps sinensis mushrooms." International Journal of Electrical and Computer Engineering (IJECE) 13, no. 1 (2023): 1142. http://dx.doi.org/10.11591/ijece.v13i1.pp1142-1151.

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<em>Cordyceps sinensis</em> is an edible mushroom found in high quantities in the regions of the Himalayas and widely considered in traditional systems of medicine. It is a non-toxic remedy mushroom and has a high measure of clinical medical benefits including cancer restraint, high blood pressure, diabetes, asthma, depression, fatigue, immune disorder, and many infections of the upper respiratory tract. The cultivation of this kind of mushroom is limited to the region of the Sikkim and to cultivate in the other regions of the country, they are need of investigation and prediction

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32

Nakamura, Kazuki, Kazumasa Shinozuka, and Noriko Yoshikawa. "Anticancer and antimetastatic effects of cordycepin, an active component of Cordyceps sinensis." Journal of Pharmacological Sciences 127, no. 1 (2015): 53–56. http://dx.doi.org/10.1016/j.jphs.2014.09.001.

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33

Chen, Yung-Chia, Ying-Hui Chen, Bo-Syong Pan, Ming-Min Chang, and Bu-Miin Huang. "Functional study of Cordyceps sinensis and cordycepin in male reproduction: A review." Journal of Food and Drug Analysis 25, no. 1 (2017): 197–205. http://dx.doi.org/10.1016/j.jfda.2016.10.020.

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34

Di Lorenzo, Ritamaria, Danila Falanga, Lucia Ricci, et al. "NAD-Driven Sirtuin Activation by Cordyceps sinensis Extract: Exploring the Adaptogenic Potential to Promote Skin Longevity." International Journal of Molecular Sciences 25, no. 8 (2024): 4282. http://dx.doi.org/10.3390/ijms25084282.

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In recent years, there has been increasing interest in utilizing Traditional Chinese Medicine principles and natural bioactive compounds to combat age-related ailments and enhance longevity. A Cordyceps sinensis mycelium hydroethanolic extract (CsEx), which was standardized in cordycepin and adenosine using UHPLC-DAD, was investigated for its adaptogenic properties using in vitro assays and a double-blind, placebo-controlled clinical trial involving 40 subjects. The CsEx demonstrated activity at a concentration of 0.0006%, significantly increasing sirtuin expression (SirT1: +33%, SirT3: +10%,

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35

Shrestha, Bhushan. "Diversity of Cordyceps Fungi in Nepal." Nepal Journal of Science and Technology 12 (July 22, 2012): 103–10. http://dx.doi.org/10.3126/njst.v12i0.6487.

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Fungi are a part of the biodiversity that play a significant role in daily livelihood of the local communities. Yarsagumba (Ophiocordyceps sinensis) is one of the highly valued medicinal fungi that grow in the Tibetan Plateau of China and alpine grasslands of Nepal, Bhutan and India. Genus Cordyceps was recently revised and divided into four genera: Cordyceps, Elaphocordyceps, Metacordyceps and Ophiocordyceps, based on molecular phylogeny and morphology. The recent revision has consequently changed the scientific name of Yarsa gumba from Cordyceps sinensis (Berk.) Sacc. to Ophiocordyceps sinen

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Liu, Haibin, Xinyue Wang, Hang Tian, et al. "Visualized Nucleic Acid Hybridization Lateral Flow Strip Integrating with Microneedle for the Point-of-Care Authentication of Ophiocordyceps sinensis." International Journal of Molecular Sciences 25, no. 24 (2024): 13599. https://doi.org/10.3390/ijms252413599.

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Due to the price and demand of Ophiocordyceps sinensis having increased dramatically, adulteration with other fungi is a common problem. Thus, a reliable method of authentic O. sinensis identification is essential. In the present work, a rapid DNA extraction and double-tailed recombinase polymerase amplification (RPA) coupled with nucleic acid hybridization lateral flow strip (NAH-LFS) was developed to distinguish authentic O. sinensis ingredients from other fungi substitutes. In the presence of O. sinensis, the RPA amplicons with two ssDNA tails in the opposite ends, which could simultaneousl

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Shirokikh, A. A. "Records of pharmacologically valuable ascomycete fungus <i>Cordyceps militaris</i> (L) Fr. in the Kirov region." Agricultural Science Euro-North-East 24, no. 6 (2023): 999–1006. http://dx.doi.org/10.30766/2072-9081.2023.24.6.999-1006.

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Fungi of the genus Cordyceps Fr. (1818) (Ascomycota: Hypocreales: Cordycipitaceae) are widely distributed throughout the world, many species are cosmopolitan. Cordyceps are known as entomopathogenic fungi that infect caterpillars and pupae of insects. The fruit bodies of Chinese cordyceps Ophiocordyceps sinensis (synonym Cordyceps sinensis (Berk.) Sacc) are also well known for their pharmacological effects and are widely used in traditional Chinese medicine for the treatment of a wide range of diseases. This species has a limited distribution and, due to the huge demand, its resources are rapi

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Lo, Hui-Chen, Tai-Hao Hsu, Shih-Te Tu, and Kwo-Chuan Lin. "Anti-hyperglycemic Activity of Natural and Fermented Cordyceps sinensis in Rats with Diabetes Induced by Nicotinamide and Streptozotocin." American Journal of Chinese Medicine 34, no. 05 (2006): 819–32. http://dx.doi.org/10.1142/s0192415x06004314.

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Our previous study demonstrated that the fruiting bodies of Cordyceps sinensis, a traditional Chinese medicine, attenuated diabetes-induced weight loss, polydipsia, and hyperglycemia in rats. In the present study, we further compared the anti-hyperglycemic activity of the fermented mycelia and broth of Cordyceps sinensis with that of the fruiting bodies. Male Wistar rats orally administered a placebo (STZ group), fruiting bodies (FB group, 1 g/day), fermented mycelia (MCS group, 1 g/day), fermented broth (BCS group, 1 g/day), or fermented mycelia plus broth (XCS group, 0.5 g/day of each) of Co

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Luitel, Himal, Tatyana Novoyatleva, Akylbek Sydykov, et al. "Yarsagumba is a Promising Therapeutic Option for Treatment of Pulmonary Hypertension due to the Potent Anti-Proliferative and Vasorelaxant Properties." Medicina 56, no. 3 (2020): 131. http://dx.doi.org/10.3390/medicina56030131.

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Background and objectives: Pulmonary hypertension (PH) is characterized by the vasoconstriction and abnormally proliferative vascular cells. The available allopathic treatment options for PH are still not able to cure the disease. Alternative medicine is becoming popular and drawing the attention of the general public and scientific communities. The entomogenous fungus Yarsagumba (Cordyceps sinensis) and its biologically active ingredient cordycepin may represent the therapeutic option for this incurable disease, owing to their anti-inflammatory, vasodilatory and anti-oxidative effects. Method

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Kuo, Yuh-Chi, Ching-Yuang Lin, Wei-Jern Tsai, Chia-Ling Wu, Chieh-Fu Chen, and Ming-Shi Shiao. "Growth Inhibitors Against Tumor Cells in Cordyceps sinensis Other than Cordycepin and Polysaccharides." Cancer Investigation 12, no. 6 (1994): 611–15. http://dx.doi.org/10.3109/07357909409023046.

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Ma, Hexin, Guofang Wang, Xiaomeng Guo, et al. "Network Pharmacology and Molecular Docking Analysis Explores the Mechanisms of Cordyceps sinensis in the Treatment of Oral Lichen Planus." Journal of Oncology 2022 (August 29, 2022): 1–13. http://dx.doi.org/10.1155/2022/3156785.

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Objective. Oral lichen planus (OLP) is the most common potentially malignant disorder of the oral cavity. This study aimed to investigate the mechanism of action of Cordyceps sinensis in the treatment of OLP and provides a theoretical support for improving current treatment regimens for OLP. Methods. The active components and therapeutic targets of Cordyceps sinensis were predicted and screened using the TCMSP, SymMap, PubMed, HIT 2.0, and PharmMapper databases, while the relevant OLP targets were predicted and screened using the DisGeNET and GeneCards databases. Protein-protein interactions (

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Uhrinová, A., and L. Ungvarská Maľučka. "Medicinal Mushrooms Ophiocordyceps Sinensis and Paecilomyces Hepiali." Folia Veterinaria 65, no. 4 (2021): 1–6. http://dx.doi.org/10.2478/fv-2021-0031.

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Abstract The fungi of the genus Ophiocordyceps sinensis (Berk.) belong to entomopathogenic fungi. Ophiocordyceps sinensis has been used as a tonic and medicinal product in China for more than 2,000 years. A number of scientific papers have described the clinical use of this parasitic fungus with subsequent biological and pharmacological effects. The various chemical compounds identified in these fungi are responsible for a wide range of biological activity: cordycepin, cordycepic acid, D-mannitol, polysaccharides, nucleotides, proteins, amino acids, and unsaturated fatty acids. Our research fo

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Li, Yu-Ling, Ling Gao, Yi-Sang Yao, et al. "Altered GC- and AT-biased genotypes of Ophiocordyceps sinensis in the stromal fertile portions and ascospores of natural Cordyceps sinensis." PLOS ONE 18, no. 6 (2023): e0286865. http://dx.doi.org/10.1371/journal.pone.0286865.

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Objective To examine multiple genotypes of Ophiocordyceps sinensis in a semi-quantitative manner in the stromal fertile portion (SFP) densely covered with numerous ascocarps and ascospores of natural Cordyceps sinensis and to outline the dynamic alterations of the coexisting O. sinensis genotypes in different developmental phases. Methods Mature Cordyceps sinensis specimens were harvested and continuously cultivated in our laboratory (altitude 2,254 m). The SFPs (with ascocarps) and fully and semi-ejected ascospores were collected for histological and molecular examinations. Biochip-based sing

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Tang, Rui, Xue-Hong Qiu, Li Cao, Hai-Lin Long, and Ri-Chou Han. "Stage- and Rearing-Dependent Metabolomics Profiling of Ophiocordyceps sinensis and Its Pipeline Products." Insects 12, no. 8 (2021): 666. http://dx.doi.org/10.3390/insects12080666.

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Cordyceps, a parasitic complex of the fungus Ophiocordyceps sinensis (Berk.) (Hypocreales: Ophiocordycipitaceae) and the ghost moth Thitarodes (Lepidoptera: Hepialidae), is a historical ethnopharmacological commodity in China. Recently, artificial cultivation of Chinese cordyceps has been established to supplement the dwindling natural resources. However, much is unknown between the natural and cultivated products in terms of nutritional aspect, which may provide essential information for quality evaluation. The current study aims to determine the metabolic profiles of 17 treatments from 3 sam

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Živković, Lada, Sunčica Borozan, Vladan Bajić, Stefana Đorđević, Aleksandar Hristov, and Biljana Spremo-Potparević. "Evaluation of antioxidant potential of Cordyceps sinensis in vitro." Medicinski casopis 53, no. 4 (2019): 129–34. http://dx.doi.org/10.5937/mckg53-24450.

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ÖNDER, Alev, Ahsen Sevde ÇINAR, and Meltem CANATAN. "Cordyceps Sinensis (Berk.) Sacc. and Its Pharmacological Importance." Journal of Literature Pharmacy Sciences 8, no. 2 (2019): 85–96. http://dx.doi.org/10.5336/pharmsci.2019-65114.

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He, Min, Chu-Yu Tang, Tao Wang, Meng-Jun Xiao, Yu-Ling Li, and Xiu-Zhang Li. "Analysis of Metabolic Profiles and Antioxidant Activity of Chinese Cordyceps, Ophiocordyceps sinensis, and Paecilomyces hepiali Based on Untargeted Metabolomics." Biology 13, no. 9 (2024): 683. http://dx.doi.org/10.3390/biology13090683.

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Chinese cordyceps (GL) is a traditional medicinal fungus, with Ophiocordyceps sinensis (O. sinensis, BL) and Paecilomyces hepiali (P. hepiali, JSB) being fungi isolated from wild Chinese cordyceps. These three species share similar chemical composition and pharmacological effects. Existing studies have primarily compared the metabolites of Chinese cordyceps and O. sinensis, overlooking the assessment of antioxidant capacity in Chinese cordyceps, P. hepiali, and O. sinensis. In this study, LC-MS/MS was employed to analyze metabolites in GL, JSB, and BL. Utilizing principal component analysis (P

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Chen, Yangyang, Zhenjiang Chen, Xiuzhang Li, Kamran Malik, and Chunjie Li. "Metagenomic Analysis: Alterations of Soil Microbial Community and Function due to the Disturbance of Collecting Cordyceps sinensis." International Journal of Molecular Sciences 25, no. 20 (2024): 10961. http://dx.doi.org/10.3390/ijms252010961.

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Soil microorganisms are critical to the occurrence of Cordyceps sinensis (Chinese Cordyceps), a medicinal fungi used in Traditional Chinese Medicine. The over-collection of Chinese Cordyceps has caused vegetation degradation and impacted the sustainable occurrence of Cordyceps. The effects of Chinese Cordyceps collection on soil microorganisms have not been reported. Metagenomic analysis was performed on the soil of collecting and non-collecting areas of production and non-production areas, respectively. C. sinensis collection showed no alteration in alpha-diversity but significantly affected

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Ho Thi, Phuong Tham. "COMPARISON OF RADICALS SCAVENGING ACTIVITY OF EXOPOLYSACCHARIDES FROM CULTURED CORDYCEPS SPP. ISOLATED IN VIET NAM." Vietnam Journal of Science and Technology 54, no. 4A (2018): 148. http://dx.doi.org/10.15625/2525-2518/54/4a/11988.

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Cordyceps is a well-known traditional medicine to heal various serious diseases for centuries. Besides, polysaccharides isolated from Cordyceps had demonstrated to exhibit potential bioactivities, especially antioxidant activity. Hence, this study concentrated on the antioxidant effects of exopolysaccharides (EPS) isolated from ten kinds of Cordyceps cultured broth. Consequently, Cordyceps sinensis cultured broth possessed the highest EPS as well as total carbohydrate content, but the nearly lowest protein content (2.75 g/l, 69.39 % and 1.01 % respectively). Most of EPSs exhibited potential ra

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Tsim, Karl W. K., and Shao P. Li. "Alternative Medicine." Asia-Pacific Biotech News 09, no. 21 (2005): 1160–64. http://dx.doi.org/10.1142/s021903030500056x.

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