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Journal articles on the topic 'Core lipids'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Zhu, Chun, Julius S. Lipp, Lars Wörmer, Kevin B. Becker, Jan M. Schröder, and Kai-Uwe Hinrichs. "Comprehensive glycerol ether lipid fingerprints through a novel reversed phase liquid chromatography–mass spectrometry protocol." Organic Geochemistry 65 (October 3, 2013): 53–62. https://doi.org/10.1016/j.orggeochem.2013.09.012.

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Abstract Glycerol ether lipid distributions have been developed as proxies for reconstructing past environmental change or, in their intact polar form, for fingerprinting the viable microbial community composition. However, due to their structural complexity, full characterization of glycerol ether lipids requires separate protocols for the analysis of the polar head groups and the alkyl chain moieties in core ether lipids. As a consequence, the valuable relationship between core ether lipid composition and specific polar head groups is often lost; this limits understanding of the diversity of

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2

Chaban, Vitaly V., and Himanshu Khandelia. "Distribution of Neutral Lipids in the Lipid Droplet Core." Journal of Physical Chemistry B 118, no. 38 (2014): 11145–51. http://dx.doi.org/10.1021/jp506693d.

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3

Chacko, Juna B., Gudanagaram R. Vijayasankar, Bendi S. Venkateswarlu, and Margret C. Rajappa. "MECHANISTIC OUTCOMES OF LIPID CORE ON SOLID LIPID NANOPARTICLE CHARACTERIZATION." INDIAN DRUGS 61, no. 02 (2024): 35–42. http://dx.doi.org/10.53879/id.61.02.13881.

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In our present study, solid lipid nanoparticles were fabricated by modified double emulsification followed by ultracentrifugation method. The SLNs of the anti-HIV drugs lamivudine, tenofovir disoproxil fumarate and efavirenz were synthesized using lipids Compritol 888 ATO, glyceryl monostearate, stearic acid and emulsifiers soy lecithin and Pluronic®F68. The synthesized SLNs were characterized for compatibility studies, mean particle size, PDI, zeta potential, surface morphology and entrapment studies. The higher amount of Compritol based SLNs formulation showed maximum entrapment efficiency w

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4

Liu, Xiao-Lei, Julius S. Lipp, Jan M. Schröder, Roger E. Summons, and Kai-Uwe Hinrichs. "Isoprenoid glycerol dialkanol diethers: a series of novel archaeal lipids in marine sediments." Organic Geochemistry 43 (November 17, 2011): 50–55. https://doi.org/10.1016/j.orggeochem.2011.11.002.

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Abstract We report a new series of archaeal lipids, widespread in marine sediments and tentatively assigned as isoprenoid glycerol dialkanol diethers (GDDs). They are structural analogs of isoprenoid glycerol dialkyl glycerol tetraethers (GDGTs), with one glycerol unit missing and with each biphytanyl moiety possessing a terminal OH group. Identification is based on molecular formulae determined from accurate mass measurement and interpretation of mass spectral fragmentation patterns. Acetylation of GDD-0 confirmed the presence of three OH groups, and ether cleavage and reduction of the produc

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Becker, Kevin W., Felix J. Elling, Marcos Y. Yoshinaga, Andrea Söllinger, Tim Urich, and Kai-Uwe Hinrichs. "Unusual Butane- and Pentanetriol-Based Tetraether Lipids in Methanomassiliicoccus luminyensis, a Representative of the Seventh Order of Methanogens." Applied and Environmental Microbiology 82, no. 15 (2016): 4505–16. http://dx.doi.org/10.1128/aem.00772-16.

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ABSTRACTA new clade of archaea has recently been proposed to constitute the seventh methanogenic order, theMethanomassiliicoccales, which is related to theThermoplasmatalesand the uncultivated archaeal clades deep-sea hydrothermal ventEuryarchaeotagroup 2 and marine group IIEuryarchaeotabut only distantly related to other methanogens. In this study, we investigated the membrane lipid composition ofMethanomassiliicoccus luminyensis, the sole cultured representative of this seventh order. The lipid inventory ofM. luminyensiscomprises a unique assemblage of novel lipids as well as lipids otherwis

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Jamme, Frédéric, Bertrand Cinquin, Yann Gohon, Eva Pereiro, Matthieu Réfrégiers, and Marine Froissard. "Synchrotron multimodal imaging in a whole cell reveals lipid droplet core organization." Journal of Synchrotron Radiation 27, no. 3 (2020): 772–78. http://dx.doi.org/10.1107/s1600577520003847.

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A lipid droplet (LD) core of a cell consists mainly of neutral lipids, triacylglycerols and/or steryl esters (SEs). The structuration of these lipids inside the core is still under debate. Lipid segregation inside LDs has been observed but is sometimes suggested to be an artefact of LD isolation and chemical fixation. LD imaging in their native state and in unaltered cellular environments appears essential to overcome these possible technical pitfalls. Here, imaging techniques for ultrastructural study of native LDs in cellulo are provided and it is shown that LDs are organized structures. Cry

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Łapińska, Urszula, Georgina Glover, Zehra Kahveci, et al. "Systematic comparison of unilamellar vesicles reveals that archaeal core lipid membranes are more permeable than bacterial membranes." PLOS Biology 21, no. 4 (2023): e3002048. http://dx.doi.org/10.1371/journal.pbio.3002048.

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One of the deepest branches in the tree of life separates the Archaea from the Bacteria. These prokaryotic groups have distinct cellular systems including fundamentally different phospholipid membrane bilayers. This dichotomy has been termed the lipid divide and possibly bestows different biophysical and biochemical characteristics on each cell type. Classic experiments suggest that bacterial membranes (formed from lipids extracted from Escherichia coli, for example) show permeability to key metabolites comparable to archaeal membranes (formed from lipids extracted from Halobacterium salinarum

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Schubotz, Florence, Sitan Xie, Julius S. Lipp, Kai-Uwe Hinrichs, and Stuart G. Wakeham. "Intact polar lipids in the water column of the eastern tropical North Pacific: abundance and structural variety of non-phosphorus lipids." Biogeosciences 15, no. 21 (2018): 6481–501. http://dx.doi.org/10.5194/bg-15-6481-2018.

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Abstract. Intact polar lipids (IPLs) are the main building blocks of cellular membranes and contain chemotaxonomic, ecophysiological and metabolic information, making them valuable biomarkers in microbial ecology and biogeochemistry. This study investigates IPLs in suspended particulate matter (SPM) in the water column of the eastern tropical North Pacific Ocean (ETNP), one of the most extensive open-ocean oxygen minimum zones (OMZs) in the world, with strong gradients of nutrients, temperature and redox conditions. A wide structural variety in polar lipid head-group composition and core struc

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9

Ramezanpour, M., M. L. Schmidt, I. Bodnariuc, et al. "Ionizable amino lipid interactions with POPC: implications for lipid nanoparticle function." Nanoscale 11, no. 30 (2019): 14141–46. http://dx.doi.org/10.1039/c9nr02297j.

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The distribution of ionizable amino lipids (KC2) is critical in structure of lipid nanoparticles, siRNA entrapment and endosomal release. Neutral KC2 segregates from phospholipids (POPC) and forms an oily core in the bilayer interior.

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10

Kim, Hyun Uk. "Lipid Metabolism in Plants." Plants 9, no. 7 (2020): 871. http://dx.doi.org/10.3390/plants9070871.

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In plants, lipids function in a variety of ways. Lipids are a major component of biological membranes and are used as a compact energy source for seed germination. Fatty acids, the major lipids in plants, are synthesized in plastid and assembled by glycerolipids or triacylglycerols in endoplasmic reticulum. The metabolism of fatty acids and triacylglycerols is well studied in most Arabidopsis model plants by forward and reverse genetics methods. However, research on the diverse functions of lipids in plants, including various crops, has yet to be completed. The papers of this Special Issue cov

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Davenport, J., D. L. Holland, and J. East. "Thermal and biochemical characteristics of the lipids of the leatherback turtle Dermochelys coriacea: evidence of endothermy." Journal of the Marine Biological Association of the United Kingdom 70, no. 1 (1990): 33–41. http://dx.doi.org/10.1017/s0025315400034172.

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Unlike other sea turtles, the leatherback Dermochelys coriacea forages widely in temperate waters during summer and dives to abyssal depths (>1000 m) where temperatures are low. There is strong anatomical plus limited physiological evidence in favour of at least facultative endothermy. The lipids of leatherbacks exhibit features which are consistent with maintenance of a core temperature above ambient levels when in cool waters. The lipid of flipper adipose tissue freezes at a lower temperature than lipids extracted from the blubber lining carapace and plastron. Lipid freezing points in lea

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Liu, Xiao-Lei, Julius S. Lipp, Jeffrey H. Simpson, Yu-Shih Lin, Roger E. Summons, and Kai-Uwe Hinrichs. "Mono- and dihydroxyl glycerol dibiphytanyl glycerol tetraethers in marine sediments: Identification of both core and intact polar lipid forms." Geochimica et Cosmochimica Acta 89 (April 28, 2012): 102–15. https://doi.org/10.1016/j.gca.2012.04.053.

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Abstract Hydroxylated glycerol dialkyl glycerol tetraethers (hydroxy-GDGTs) were detected in marine sediments of diverse depositional regimes and ages. Mass spectrometric evidence, complemented by information gleaned from two-dimensional (2D) <sup>1</sup>H–<sup>13</sup>C nuclear magnetic resonance (NMR) spectroscopy on minute quantities of target analyte isolated from marine sediment, allowed us to identify one major compound as a monohydroxy-GDGT with acyclic biphytanyl moieties (OH-GDGT-0). NMR spectroscopic and mass spectrometric data indicate the presence of a tertiary hydroxyl group

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13

Coffinet, Sarah, Travis B. Meador, Lukas Mühlena, et al. "Structural elucidation and environmental distributions of butanetriol and pentanetriol dialkyl glycerol tetraethers (BDGTs and PDGTs)." Biogeosciences 17, no. 2 (2020): 317–30. http://dx.doi.org/10.5194/bg-17-317-2020.

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Abstract. Butanetriol and pentanetriol dialkyl glycerol tetraethers (BDGTs and PDGTs) are membrane lipids, recently discovered in sedimentary environments and in the methanogenic archaeon Methanomassiliicoccus luminyensis. They possess an unusual structure, which challenges fundamental assumptions in lipid biochemistry. Indeed, they bear a butanetriol or a pentanetriol backbone instead of a glycerol at one end of their core structure. In this study, we unambiguously located the additional methyl group of the BDGT compound on the C3 carbon of the lipid backbone via high-field nuclear magnetic r

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14

Zheng, Minying, Mia Falkeborg, Yan Zheng, Tiankui Yang, and Xuebing Xu. "Formulation and characterization of nanostructured lipid carriers containing a mixed lipids core." Colloids and Surfaces A: Physicochemical and Engineering Aspects 430 (August 2013): 76–84. http://dx.doi.org/10.1016/j.colsurfa.2013.03.070.

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15

Bitman, Joel, Lois M. Freed, Margaret C. Neville, D. L. Wood, Paul Hamosh, and Margit Hamosh. "Lipid Composition of Prepartum Human Mammary Secretion and Postpartum Milk." Journal of Pediatric Gastroenterology and Nutrition 5, no. 4 (1986): 608–15. http://dx.doi.org/10.1002/j.1536-4801.1986.tb09139.x.

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SummaryChanges in lipid composition of mammary secretions of five women were studied at two prepartum periods and compared with composition of colostrum, transitional, and mature human milk. Fat content was ∼1 g/dl during early (‐42.0 days before parturition) and late (‐9.5 days) prepartum periods and increased to 3–4 g/dl in colostrum (3.0 days post partum), transitional (7.2 days), and mature milk (56.2 days). Most of the lipid present was triglyceride either pre‐ (93%) or post‐ (97%) partum. All fat globule core lipids, with the exception of 1,3‐diglycerides, increased from prepartum concen

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16

Ferrante, Giulio, James C. Richards, and G. Dennis Sprott. "Structures of polar lipids from the thermophilic, deep-sea archaeohacterium Methanococcus jannaschii." Biochemistry and Cell Biology 68, no. 1 (1990): 274–83. http://dx.doi.org/10.1139/o90-038.

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Cells of Methanococcus jannaschii, grown at 65 °C in a defined medium, contained 7% of lipid composed of 87% polar and 13% neutral components. Within the polar fraction 16 lipids were resolved by thin-layer chromatography, 4 of which were present in trace amounts. Staining reactions demonstrated that the more abundant lipids were glycolipids, aminophospholipids, and an aminophosphoglycolipid. Most of the polar fraction (82%) consisted of five diether lipids, which were purified and their structures were resolved largely through nuclear magnetic resonance, mass spectrometry, and optical rotatio

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Matarazzo, Ananda P., Carlos A. Rios, Gabriela Gerônimo, Roberta Ondei, Eneida de Paula, and Márcia C. Breitkreitz. "Development of a Versatile Nanostructured Lipid Carrier (NLC) Using Design of Experiments (DoE)—Part II: Incorporation and Stability of Butamben with Different Surfactants." Pharmaceutics 16, no. 7 (2024): 863. http://dx.doi.org/10.3390/pharmaceutics16070863.

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Nanostructured lipid carriers (NLCs) are typically composed of liquid lipids, solid lipids, and surfactants, enabling the encapsulation of lipophilic drugs. Butamben is a Class II anesthetic drug, according to the Biopharmaceutical Classification System (BCS); it has a log P of 2.87 and is considered a ‘brick dust’ (poorly water-soluble and poorly lipid-soluble) drug. This characteristic poses a challenge for the development of NLCs, as they are not soluble in the liquid lipid present in the NLC core. In a previous study, we developed an NLC core consisting of a solid lipid (CrodamolTM CP), a

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Tourte, Maxime, Vanessa Kuentz, Philippe Schaeffer, Vincent Grossi, Anais Cario, and Philippe M. Oger. "Novel Intact Polar and Core Lipid Compositions in the Pyrococcus Model Species, P. furiosus and P. yayanosii, Reveal the Largest Lipid Diversity Amongst Thermococcales." Biomolecules 10, no. 6 (2020): 830. http://dx.doi.org/10.3390/biom10060830.

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Elucidating the lipidome of Archaea is essential to understand their tolerance to extreme environmental conditions. Previous characterizations of the lipid composition of Pyrococcus species, a model genus of hyperthermophilic archaea belonging to the Thermococcales order, led to conflicting results, which hindered the comprehension of their membrane structure and the putative adaptive role of their lipids. In an effort to clarify the lipid composition data of the Pyrococcus genus, we thoroughly investigated the distribution of both the core lipids (CL) and intact polar lipids (IPL) of the mode

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Jain, Shweta, Mudit Kumar, Pushpendra Kumar, et al. "Lipid–Polymer Hybrid Nanosystems: A Rational Fusion for Advanced Therapeutic Delivery." Journal of Functional Biomaterials 14, no. 9 (2023): 437. http://dx.doi.org/10.3390/jfb14090437.

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Lipid nanoparticles (LNPs) are spherical vesicles composed of ionizable lipids that are neutral at physiological pH. Despite their benefits, unmodified LNP drug delivery systems have substantial drawbacks, including a lack of targeted selectivity, a short blood circulation period, and in vivo instability. lipid–polymer hybrid nanoparticles (LPHNPs) are the next generation of nanoparticles, having the combined benefits of polymeric nanoparticles and liposomes. LPHNPs are being prepared from both natural and synthetic polymers with various techniques, including one- or two-step methods, emulsifi

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Rebholz, Sandra L., Katie T. Burke, Qing Yang, Patrick Tso, and Laura A. Woollett. "Dietary fat impacts fetal growth and metabolism: uptake of chylomicron remnant core lipids by the placenta." American Journal of Physiology-Endocrinology and Metabolism 301, no. 2 (2011): E416—E425. http://dx.doi.org/10.1152/ajpendo.00619.2010.

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The fetus requires significant energy for growth and development. Although glucose is a major source of energy for the fetus, other maternal nutrients also appear to promote growth. Thus, the goal of these studies was to determine whether triglyceride-rich remnants are taken up by the placenta and whether maternal dietary lipids, independently of adiposity, can impact fetal growth. To accomplish our first goal, chylomicron particles were duallly labeled with cholesteryl ester and triglycerides. The placenta took up remnant particles/core lipids at rates greater than adipose tissue and skeletal

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SUGAI, Akihiko, Yaeko MASUCHI, Ikuko UDA, Toshihiro ITOH, and Yuko H. ITOH. "Core Lipids of Hyperthermophilic Archaeon, Pyrococcus horikoshii OT3." Journal of Japan Oil Chemists' Society 49, no. 7 (2000): 695–700. http://dx.doi.org/10.5650/jos1996.49.695.

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LUSA, Sari, Matti JAUHIAINEN, Jari METSO, Pentti SOMERHARJU, and Christian EHNHOLM. "The mechanism of human plasma phospholipid transfer protein-induced enlargement of high-density lipoprotein particles: evidence for particle fusion." Biochemical Journal 313, no. 1 (1996): 275–82. http://dx.doi.org/10.1042/bj3130275.

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1. Phospholipid transfer protein (PLTP) mediates conversion of high-density lipoprotein (HDL3) to large particles, with concomitant release of apolipoprotein A-I (apoA-I). To study the mechanisms involved in this conversion, reconstituted HDL (rHDL) particles containing either fluorescent pyrenylacyl cholesterol ester (PyrCE) in their core (PyrCE-rHDL) or pyrenylacyl phosphatidylcholine (PyrPC) in their surface lipid layer (PyrPC-rHDL) were prepared. Upon incubation with PLTP they behaved as native HDL3, in that their size increased considerably. 2. When PyrPC-rHDL was incubated with HDL3 in t

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Meanwell, Michael W., Connor O’Sullivan, Perry Howard, and Thomas M. Fyles. "Branched-chain and dendritic lipids for nanoparticles." Canadian Journal of Chemistry 95, no. 2 (2017): 120–29. http://dx.doi.org/10.1139/cjc-2016-0462.

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Lipid nanoparticles (LNPs) for drug-delivery applications are largely derived from natural lipids. Synthetic lipids, particularly those incorporating branched hydrocarbons and hyper-branched hydrocarbon architectures, may afford enhanced lipophilicity with enhanced fluidity and thereby lead to LNP stabilization. Hydrocarbon anchors based on serinol diesters were prepared from linear Cn (n = 14, 16, 18) and branched (n = 16) acids with Boc-protected serinol. These diesters were further dimerized on an iminodiacetamide backbone to provide eight branched-chain and dendritic lipid anchors. Derivat

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Zhu, Chun, Travis B. Meador, Wolf Dummann, and Kai-Uwe Hinrichs. "Identification of unusual butanetriol dialkyl glycerol tetraether and pentanetriol dialkyl glycerol tetraether lipids in marine sediments." Rapid Communications in Mass Spectrometry 28 (December 27, 2013): 332–38. https://doi.org/10.1002/rcm.6792.

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RATIONALE: Glycerol serves as the principal backbone moiety bound to various acyl/alkyl chains for membrane lipids of <em>Eukarya</em>, <em>Bacteria</em>, and <em>Archaea</em>. In this study, we report a suite of unusual tetraether lipids in which one of the two conventional glycerol backbones is substituted by butanetriol or pentanetriol. METHODS: Identification of these lipids was achieved via diagnostic fragments and their expected acetylation products using liquid chromatography/mass spectrometry (LC/MS), and their diagnostic ether cleavage products using gas chromatography/mass spectromet

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Wei, Yuli, Jinxiang Wang, Jie Liu, et al. "Spatial Variations in Archaeal Lipids of Surface Water and Core-Top Sediments in the South China Sea and Their Implications for Paleoclimate Studies." Applied and Environmental Microbiology 77, no. 21 (2011): 7479–89. http://dx.doi.org/10.1128/aem.00580-11.

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ABSTRACTThe South China Sea (SCS) is the largest marginal sea of the western Pacific Ocean, yet little is known about archaeal distributions and TEX86-based temperatures in this unique oceanic setting. Here we report findings of abundances in both core lipids (CL) and intact polar lipids (IPL) ofArchaeafrom surface water (CL only) and core-top sediments from different regions of the SCS. TEX86-derived temperatures were also calculated for these samples. The surface water had extremely low abundances of CL (average of 0.05 ± 0.13 ng/liter;n= 75), with higher values present in regions where upwe

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Spencer, Cierra, Barbara A. Bensing, Nagendra N. Mishra, and Paul M. Sullam. "Membrane trafficking of the bacterial adhesin GspB and the accessory Sec transport machinery." Journal of Biological Chemistry 294, no. 5 (2018): 1502–15. http://dx.doi.org/10.1074/jbc.ra118.005657.

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The serine-rich repeat (SRR) glycoproteins of Gram-positive bacteria are large, cell wall–anchored adhesins that mediate binding to many host cells and proteins and are associated with bacterial virulence. SRR glycoproteins are exported to the cell surface by the accessory Sec (aSec) system comprising SecA2, SecY2, and 3–5 additional proteins (Asp1 to Asp5) that are required for substrate export. These adhesins typically have a 90-amino acid-long signal peptide containing an elongated N-region and a hydrophobic core. Previous studies of GspB (the SRR adhesin ofStreptococcus gordonii) have show

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Afshinnia, Farsad, Thekkelnaycke M. Rajendiran, Tanu Soni та ін. "Impaired β-Oxidation and Altered Complex Lipid Fatty Acid Partitioning with Advancing CKD". Journal of the American Society of Nephrology 29, № 1 (2017): 295–306. http://dx.doi.org/10.1681/asn.2017030350.

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Studies of lipids in CKD, including ESRD, have been limited to measures of conventional lipid profiles. We aimed to systematically identify 17 different lipid classes and associate the abundance thereof with alterations in acylcarnitines, a metric of β-oxidation, across stages of CKD. From the Clinical Phenotyping Resource and Biobank Core (CPROBE) cohort of 1235 adults, we selected a panel of 214 participants: 36 with stage 1 or 2 CKD, 99 with stage 3 CKD, 61 with stage 4 CKD, and 18 with stage 5 CKD. Among participants, 110 were men (51.4%), 64 were black (29.9%), and 150 were white (70.1%),

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Wörmer, Lars, Julius S. Lipp, Jan M. Schröder, and Kai-Uwe Hinrichs. "Application of two new LC–ESI–MS methods for improved detection of intact polar lipids (IPLs) in environmental samples." Organic Geochemistry 59 (March 20, 2013): 10–21. https://doi.org/10.1016/j.orggeochem.2013.03.004.

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Abstract Intact polar lipid distributions have become a valuable tool for the study of microbial ecosystems. In order to expand the detection and interpretation of the presence of these lipids, improved analytical methods are needed. Therefore, two high pressure liquid chromatography–electrospray ionization tandem mass spectrometry (HPLC–ESI–MS<sup>2</sup>) methods, based on hydrophilic interaction chromatography (HILIC) and reversed phase (RP) chromatography were developed, taking advantage of new chromatographic possibilities such as smaller particle size and recently devel

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Li, Xuehan, Zemin Li, Minghua Zhao, et al. "Skeletal Muscle Lipid Droplets and the Athlete’s Paradox." Cells 8, no. 3 (2019): 249. http://dx.doi.org/10.3390/cells8030249.

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The lipid droplet (LD) is an organelle enveloped by a monolayer phospholipid membrane with a core of neutral lipids, which is conserved from bacteria to humans. The available evidence suggests that the LD is essential to maintaining lipid homeostasis in almost all organisms. As a consequence, LDs also play an important role in pathological metabolic processes involving the ectopic storage of neutral lipids, including type 2 diabetes mellitus (T2DM), atherosclerosis, steatosis, and obesity. The degree of insulin resistance in T2DM patients is positively correlated with the size of skeletal musc

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Sinninghe Damsté, Jaap S., W. Irene C. Rijpstra, Ellen C. Hopmans, et al. "Intact Polar and Core Glycerol Dibiphytanyl Glycerol Tetraether Lipids of Group I.1a and I.1b Thaumarchaeota in Soil." Applied and Environmental Microbiology 78, no. 19 (2012): 6866–74. http://dx.doi.org/10.1128/aem.01681-12.

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ABSTRACTEcological studies of thaumarchaeota often apply glycerol dibiphytanyl glycerol tetraether (GDGT)-based intact membrane lipids. However, these components have only been characterized for thaumarchaeota from aquatic environments. Thaumarchaeota have been shown to play an important role in the nitrogen cycle in soil as ammonium oxidizers, and GDGTs are common lipids encountered in soil. We report the core and intact polar lipid (IPL) GDGTs produced by three newly available thaumarchaeota isolated from grassland soil in Austria (“Nitrososphaera viennensis,” group I.1b) and enriched from a

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Chime, Salome A., Paul A. Akpa, and Anthony A. Attama. "The Utility of Lipids as Nanocarriers and Suitable Vehicle in Pharmaceutical Drug Delivery." Current Nanomaterials 4, no. 3 (2019): 160–75. http://dx.doi.org/10.2174/2405461504666191016091827.

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Lipid based excipients have gained popularity recently in the formulation of drugs in order to improve their pharmacokinetic profiles. For drugs belonging to the Biopharmaceutics Classification System (BCS) class II and IV, lipid excipients play vital roles in improving their pharmacokinetics properties. Various nanocarriers viz: Solid lipid nanoparticles, nanostructured lipid carriers, selfnanoemulsifying drug delivery systems (SNEDDS), nanoliposomes and liquid crystal nanoparticles have been employed as delivery systems for such drugs with evident successes. Lipid-based nanotechnology have b

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Al-Mahmood, AK, SF Afrin, and N. Hoque. "Dyslipidemia in Insulin Resistance: Cause or Effect." Bangladesh Journal of Medical Biochemistry 7, no. 1 (2014): 27–31. http://dx.doi.org/10.3329/bjmb.v7i1.18576.

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Lipids are of one of the four basic types of molecules of life and its derivatives serve diverse functions in the body. Generally acclaimed functions of lipids include shock absorption and insulation, and energy storage of the body. Phospholipids and cholesterol form the integral part of cell membrane. In addition cholesterol serves as the precursor for bile salts, male and female sex hormones, vitamin D and adrenocortical hormones. Complex lipids consist of neutral lipid core of cholesterol esters and or triacylglycerol and proteins are the chylomicrons, VLDL, LDL and HDL which serve as the c

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Kassan, Adam, Albert Herms, Andrea Fernández-Vidal, et al. "Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains." Journal of Cell Biology 203, no. 6 (2013): 985–1001. http://dx.doi.org/10.1083/jcb.201305142.

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Control of lipid droplet (LD) nucleation and copy number are critical, yet poorly understood, processes. We use model peptides that shift from the endoplasmic reticulum (ER) to LDs in response to fatty acids to characterize the initial steps of LD formation occurring in lipid-starved cells. Initially, arriving lipids are rapidly packed in LDs that are resistant to starvation (pre-LDs). Pre-LDs are restricted ER microdomains with a stable core of neutral lipids. Subsequently, a first round of “emerging” LDs is nucleated, providing additional lipid storage capacity. Finally, in proportion to lip

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Gretskaya, Nataliya, Mikhail Akimov, Dmitry Andreev, et al. "Multicomponent Lipid Nanoparticles for RNA Transfection." Pharmaceutics 15, no. 4 (2023): 1289. http://dx.doi.org/10.3390/pharmaceutics15041289.

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Despite the wide variety of available cationic lipid platforms for the delivery of nucleic acids into cells, the optimization of their composition has not lost its relevance. The purpose of this work was to develop multi-component cationic lipid nanoparticles (LNPs) with or without a hydrophobic core from natural lipids in order to evaluate the efficiency of LNPs with the widely used cationic lipoid DOTAP (1,2-dioleoyloxy-3-[trimethylammonium]-propane) and the previously unstudied oleoylcholine (Ol-Ch), as well as the ability of LNPs containing GM3 gangliosides to transfect cells with mRNA and

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Shimobayashi, Shunsuke F., and Yuki Ohsaki. "Universal phase behaviors of intracellular lipid droplets." Proceedings of the National Academy of Sciences 116, no. 51 (2019): 25440–45. http://dx.doi.org/10.1073/pnas.1916248116.

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Lipid droplets are cytoplasmic microscale organelles involved in energy homeostasis and handling of cellular lipids and proteins. The core structure is mainly composed of two kinds of neutral lipids, triglycerides and cholesteryl esters, which are coated by a phospholipid monolayer and proteins. Despite the liquid crystalline nature of cholesteryl esters, the connection between the lipid composition and physical states is poorly understood. Here, we present a universal intracellular phase diagram of lipid droplets, semiquantitatively consistent with the in vitro phase diagram, and reveal that

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Nida, Parveen *. "SOLID LIPID NANOPARTICLE: A NOVEL APPROACH IN DRUG DELIVERY SYSTEM." Journal of Pharma Research 8, no. 5 (2019): 341–45. https://doi.org/10.5281/zenodo.3236717.

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<strong><em>ABSTRACT</em></strong> <strong><em>T</em></strong><em>he solid lipid nanoparticles possess a lipid core matrix in a nanometer range, stabilized by a surfactant layer. These are based on biocompatible lipids and provide sustained effect on the formulation either by diffusion or dissolution. SLN have several advantages over other colloidal carriers, such as the possibility of controlling drug release, long term stability, drug targeting, and good drug loading of drugs may it be lipophilic or hydrophilic, free from biotoxicity due to the use of physiological lipids. The use of solid l

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Basso, João, Maria Mendes, Tânia Cova, et al. "A Stepwise Framework for the Systematic Development of Lipid Nanoparticles." Biomolecules 12, no. 2 (2022): 223. http://dx.doi.org/10.3390/biom12020223.

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A properly designed nanosystem aims to deliver an optimized concentration of the active pharmaceutical ingredient (API) at the site of action, resulting in a therapeutic response with reduced adverse effects. Due to the vast availability of lipids and surfactants, producing stable lipid dispersions is a double-edged sword: on the one hand, the versatility of composition allows for a refined design and tuning of properties; on the other hand, the complexity of the materials and their physical interactions often result in laborious and time-consuming pre-formulation studies. However, how can the

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Isomaa, Boris, Henry Hägerstrand, and Gun I. L. Paatero. "Membrane Alterations Induced by Amphiphiles." Alternatives to Laboratory Animals 16, no. 3 (1989): 274–80. http://dx.doi.org/10.1177/026119298901600312.

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Amphiphilic compounds with distinct apolar and polar parts are readily intercalated into the erythrocyte membrane. When intercalated into the membrane, amphiphiles are probably orientated so that the polar head is at the polar-apolar interface of the lipid bilayer and the hydrophobic part within the apolar core of the bilayer. However, by virtue of their difference in molecular shape from the bulk lipids of the lipid bilayer, it is possible that the intercalated amphiphiles are partly segregated from bulk lipids and accumulate at protein-lipid interfaces in the bilayer, where the packing of th

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Chuang, Skylar T., Siobanth Cruz, and Vasanthy Narayanaswami. "Reconfiguring Nature’s Cholesterol Accepting Lipoproteins as Nanoparticle Platforms for Transport and Delivery of Therapeutic and Imaging Agents." Nanomaterials 10, no. 5 (2020): 906. http://dx.doi.org/10.3390/nano10050906.

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Apolipoproteins are critical structural and functional components of lipoproteins, which are large supramolecular assemblies composed predominantly of lipids and proteins, and other biomolecules such as nucleic acids. A signature feature of apolipoproteins is the preponderance of amphipathic α-helical motifs that dictate their ability to make extensive non-covalent inter- or intra-molecular helix–helix interactions in lipid-free states or helix–lipid interactions with hydrophobic biomolecules in lipid-associated states. This review focuses on the latter ability of apolipoproteins, which has be

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Schouten, Stefan, Ellen C. Hopmans, Marianne Baas, et al. "Intact Membrane Lipids of “Candidatus Nitrosopumilus maritimus,” a Cultivated Representative of the Cosmopolitan Mesophilic Group I Crenarchaeota." Applied and Environmental Microbiology 74, no. 8 (2008): 2433–40. http://dx.doi.org/10.1128/aem.01709-07.

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ABSTRACT In this study we analyzed the membrane lipid composition of “Candidatus Nitrosopumilus maritimus,” the only cultivated representative of the cosmopolitan group I crenarchaeota and the only mesophilic isolate of the phylum Crenarchaeota. The core lipids of “Ca. Nitrosopumilus maritimus” consisted of glycerol dialkyl glycerol tetraethers (GDGTs) with zero to four cyclopentyl moieties. Crenarchaeol, a unique GDGT containing a cyclohexyl moiety in addition to four cyclopentyl moieties, was the most abundant GDGT. This confirms unambiguously that crenarchaeol is synthesized by species belo

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Braun, R. Jay, and Jessica M. J. Swanson. "Capturing the Liquid-Crystalline Phase Transformation: Implications for Protein Targeting to Sterol Ester-Rich Lipid Droplets." Membranes 12, no. 10 (2022): 949. http://dx.doi.org/10.3390/membranes12100949.

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Lipid droplets are essential organelles that store and traffic neutral lipids. The phospholipid monolayer surrounding their neutral lipid core engages with a highly dynamic proteome that changes according to cellular and metabolic conditions. Recent work has demonstrated that when the abundance of sterol esters increases above a critical concentration, such as under conditions of starvation or high LDL exposure, the lipid droplet core can undergo an amorphous to liquid-crystalline phase transformation. Herein, we study the consequences of this transformation on the physical properties of lipid

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He, P., A. Radunz, K. P. Bader, and G. H. Schmid. "Quantitative Changes of the Lipid and Fatty Acid Composition of Leaves of Aleurites montana as a Consequence of Growth under 700 ppm CO2 in the Atmosphere." Zeitschrift für Naturforschung C 51, no. 11-12 (1996): 833–40. http://dx.doi.org/10.1515/znc-1996-11-1211.

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Abstract Leaf lipids of Aleurites plants that were cultivated for 5 months in air containing 700 ppm CO2, were compared to those of control plants cultivated at 350 ppm CO2. The content of ether soluble lipids referred to dry matter is the same in CO2-and control plants. The comparison of lipids analyzed as the pigments chlorophyll and carotenoids, phospholipids and glycolipids shows that the ratio of phospholipids and glycolipids is slightly shifted in favor of phospholipids in CO2-plants. Thus, within the group of phospholipids, phosphatidylglycerol and phosphatidylinositol occur in higher c

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Li, Hao, Panqi Song, Yiwen Li, et al. "Mesoscopic Structure of Lipid Nanoparticles Studied by Small-Angle X-Ray Scattering: A Spherical Core-Triple Shell Model Analysis." Membranes 15, no. 5 (2025): 153. https://doi.org/10.3390/membranes15050153.

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Lipid nanoparticles (LNPs) are widely recognized as effective drug delivery systems for RNA therapeutics because their efficacy is critically dependent on structural organization. The mesoscopic architecture of these multicomponent systems, which is governed by interactions among ionizable lipids, structural lipids, nucleic acids, and stabilizers, dictates encapsulation efficiency, biodistribution, and therapeutic performance. Although small-angle X-Ray scattering (SAXS) enables nanostructure characterization, the absence of suitable analytical models has hindered LNP development. Here, we pre

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Bill, Mona-Katharina, Stephan Brinkmann, Markus Oberpaul, et al. "Novel Glycerophospholipid, Lipo- and N-acyl Amino Acids from Bacteroidetes: Isolation, Structure Elucidation and Bioactivity." Molecules 26, no. 17 (2021): 5195. http://dx.doi.org/10.3390/molecules26175195.

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The ‘core’ metabolome of the Bacteroidetes genus Chitinophaga was recently discovered to consist of only seven metabolites. A structural relationship in terms of shared lipid moieties among four of them was postulated. Here, structure elucidation and characterization via ultra-high resolution mass spectrometry (UHR-MS) and nuclear magnetic resonance (NMR) spectroscopy of those four lipids (two lipoamino acids (LAAs), two lysophosphatidylethanolamines (LPEs)), as well as several other undescribed LAAs and N-acyl amino acids (NAAAs), identified during isolation were carried out. The LAAs represe

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S. Patil, Snehal, Akshay R. Yadav, Rohan R. Vakhariya, Akash Kere, Sadik Sayyad, and Shweta Patil. "“Design, Evaluation and Optimization of Novel Topical Drug Delivery System of Antifungal Agent”." Cuestiones de Fisioterapia 54, no. 3 (2025): 1174–86. https://doi.org/10.48047/abpsd215.

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The core of nanostructured lipid carriers (NLCs), which are colloidal drug delivery systems at the nanoscale, is a lipid mixture made up of both liquid and solid lipids. In contrast to polymeric or metallic nanoparticles, this lipid-based nanosystem is presented as a safe, non-toxic, and biocompatible nano-drug delivery method. Optimizing and characterizing a transdermal drug delivery system loaded with antifungal medications using Nanostructured Lipid Carriers (NLC) is the objective of this work. By extending the drug release via the NLC transdermal gel, this study aims to optimize NLCs and i

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Gorospe, Berta, José J. G. Moura, Carlos Gutierrez-Merino, and Alejandro K. Samhan-Arias. "Biochemical and Biophysical Characterization of the Caveolin-2 Interaction with Membranes and Analysis of the Protein Structural Alteration by the Presence of Cholesterol." International Journal of Molecular Sciences 23, no. 23 (2022): 15203. http://dx.doi.org/10.3390/ijms232315203.

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Caveolin-2 is a protein suitable for the study of interactions of caveolins with other proteins and lipids present in caveolar lipid rafts. Caveolin-2 has a lower tendency to associate with high molecular weight oligomers than caveolin-1, facilitating the study of its structural modulation upon association with other proteins or lipids. In this paper, we have successfully expressed and purified recombinant human caveolin-2 using E. coli. The structural changes of caveolin-2 upon interaction with a lipid bilayer of liposomes were characterized using bioinformatic prediction models, circular dic

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Baumann, Lydia M. F., Ruth-Sophie Taubner, Kinga Oláh, et al. "Quantitative Analysis of Core Lipid Production in Methanothermobacter marburgensis at Different Scales." Bioengineering 9, no. 4 (2022): 169. http://dx.doi.org/10.3390/bioengineering9040169.

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Archaeal lipids have a high biotechnological potential, caused by their high resistance to oxidative stress, extreme pH values and temperatures, as well as their ability to withstand phospholipases. Further, methanogens, a specific group of archaea, are already well-established in the field of biotechnology because of their ability to use carbon dioxide and molecular hydrogen or organic substrates. In this study, we show the potential of the model organism Methanothermobacter marburgensis to act both as a carbon dioxide based biological methane producer and as a potential supplier of archaeal

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Labahn, Jakob, Lucas Bittner, Philip Hirschmann, et al. "<sup>18</sup>O analyses of bulk lipids as novel paleoclimate tool in loess research – a pilot study." E&G Quaternary Science Journal 71, no. 1 (2022): 83–90. http://dx.doi.org/10.5194/egqsj-71-83-2022.

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Abstract. The analysis of the stable oxygen isotopes 18O and 16O has revolutionized paleoclimate research since the middle of the last century. Particularly, δ18O of ice cores from Greenland and Antarctica is used as a paleotemperature proxy, and δ18O of deep-sea sediments is used as a proxy for global ice volume. Important terrestrial archives to which δ18O as a paleoclimate proxy is successfully applied are speleothems, lake sediments, or tree rings. By contrast, δ18O applications to loess–paleosol sequences (LPSs) are scarce. Here we present a first continuous δ18O record (n=50) for the LPS

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Wu, Danxia, Muhammad Saleem, Tengbing He, and Guandi He. "The Mechanism of Metal Homeostasis in Plants: A New View on the Synergistic Regulation Pathway of Membrane Proteins, Lipids and Metal Ions." Membranes 11, no. 12 (2021): 984. http://dx.doi.org/10.3390/membranes11120984.

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Heavy metal stress (HMS) is one of the most destructive abiotic stresses which seriously affects the growth and development of plants. Recent studies have shown significant progress in understanding the molecular mechanisms underlying plant tolerance to HMS. In general, three core signals are involved in plants’ responses to HMS; these are mitogen-activated protein kinase (MAPK), calcium, and hormonal (abscisic acid) signals. In addition to these signal components, other regulatory factors, such as microRNAs and membrane proteins, also play an important role in regulating HMS responses in plan

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Nakagawa, Kazunori, Mitsuru Tanaka, Tae Hun Hahm, et al. "Accumulation of Plasma-Derived Lipids in the Lipid Core and Necrotic Core of Human Atheroma: Imaging Mass Spectrometry and Histopathological Analyses." Arteriosclerosis, Thrombosis, and Vascular Biology, September 2, 2021. http://dx.doi.org/10.1161/atvbaha.121.316154.

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Objective: To clarify the pathogenesis of human atheroma, the origin of deposited lipids, the developmental mechanism of liponecrotic tissue, and the significance of the oxidation of phospholipids were investigated using mass spectrometry-aided imaging and immunohistochemistry. Approach and Results: Atherosclerotic lesions in human coronary arteries were divided into 3 groups: pathological intimal thickening with lipid pool, atheroma with lipid core, and atheroma with necrotic core. The lipid pool and lipid core were characterized by the deposition of extracellular lipids. The necrotic core co

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