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Journal articles on the topic 'Cornea Eye'

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1

Daxer, Albert. "Biomechanics of the Cornea." International Journal of Keratoconus and Ectatic Corneal Diseases 3, no. 2 (2014): 57–62. http://dx.doi.org/10.5005/jp-journals-10025-1080.

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ABSTRACT The purpose of this article is to provide an applicable and easy-to-use mathematical model of the biomechanics of the cornea. The new spherical dome model considers not only the heterogeneity of the tunica of the eye and distinguishes structurally between cornea, limbus and sclera. It also implements the structural anisotropy inside the corneal stroma caused by the corneas lamellar structure as well as the asphericity of the corneal shape. How to cite this article Daxer A. Biomechanics of the Cornea. Int J Kerat Ect Cor Dis 2014;3(2):57-62.
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2

Neha Singh, Jat. "Donor profile and trends of eye donation in Central India." International Journal of Clinical and Experimental Ophthalmology 5, no. 1 (2021): 005–8. http://dx.doi.org/10.29328/journal.ijceo.1001035.

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Background: The present study was conducted to study the donor profile and to assess the trends of cornea donation. Methodology: This was conducted as a hospital based cross sectional study at a tertiary care centre in Central India for a period of 5 years. Data was retrieved from 70 patients from eye bank who filled form of eye donation at Eye bank of our institution. Sociodemographic profile of donors, cause of death and time since death was recorded. Source of information regarding corneal donation and reason for not willing to donate the cornea for research purpose was recorded from the fi
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3

Terzariol, Mariana, Paula S. Hünning, Gustavo Brambatti, Luciane de Albuquerque, Carolina Neumann, and João A. T. Pigatto. "Effects of intracameral brilliant blue on the corneal endothelium of swine: in vitro study." Pesquisa Veterinária Brasileira 36, no. 8 (2016): 775–80. http://dx.doi.org/10.1590/s0100-736x2016000800016.

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Abstract: The aim was to investigate the ultrastructural changes in the corneal endothelium of pigs induced by intracameral 0.05% brilliant blue. Twenty swine corneas were separated into two groups, the right eye bulbs (control group) and the left eye bulbs (experimental group) of the same animal. All the eye bulbs were evaluated with specular microscopy. The cornea of the right eye bulbs was excised and in the left eye bulbs 0.2ml of 0.05% brilliant blue vital dye (OPTH-blue±) was injected into the anterior chamber, where it remained for one minute. Then the anterior chamber was cleaned with
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4

Safi, Tarek, Loay Daas, Gian-Luca Kiefer, et al. "Semiquantitative Criteria in the Eye Bank That Correlate with Cornea Guttata in Donor Corneas." Klinische Monatsblätter für Augenheilkunde 238, no. 06 (2021): 680–87. http://dx.doi.org/10.1055/a-1498-1846.

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Abstract Background Cornea guttata may not be recognized in the eye bank and recent studies have displayed that guttae are transplanted in about 15% of cases in varying severities. The purpose of this study was to establish semiquantitative criteria for the detection of cornea guttata in donor corneas in the eye bank. Methods In this retrospective cohort study, preoperative endothelial pictures of donor corneas were collected and classified according to the post-penetrating keratoplasty cornea guttata grade into three distinct groups: group 1 consists of healthy corneas with no guttae (guttata
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5

Pai, Vijay, Jayaram Shetty, and Hrishikesh Amin. "TRANSPOSITIONAL AUTOKERATOPLASTY." Journal of Health and Allied Sciences NU 01, no. 01/03 (2011): 54–56. http://dx.doi.org/10.1055/s-0040-1703521.

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AbstractRejection is the most common cause for corneal graft failure1,2. Therefore, for obvious reason, ideal material for corneal graft is the host's own cornea, either from the same eye or the fellow eye, which is totally blind from the cause that leaves the cornea healthy and intact or possibly, from an identical twin, that has a cornea to spare for the same reason. Herewith, we report a case of Transpositional Autokeratoplasty.
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Shirai, Kumi, Yuka Okada, Yasushi Nakamura, and Shizuya Saika. "Histopathological Features in a Case of Peters' Anomaly with Acquired Corneal Staphyloma." Case Reports in Ophthalmological Medicine 2011 (2011): 1–5. http://dx.doi.org/10.1155/2011/418048.

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We report a case of corneal staphyloma histologically diagnosed as caused by Peters' anomaly. A 62-year-old male had a protruding opaque vascularized cornea that began to bulge from six months ago in the right eye. Since his right eye was blind and he wanted us to remove the eyeball for cosmetic improvement, we enucleated the affected eye. The enucleated tissue was fixed in formalin and embedded in paraffin for histological examination. Hematoxylin and eosin staining showed that the cornea lacked the posterior part of the corneal stroma and Descemet's membrane in the central region and the ent
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7

Singh, Manmohan, Achuth Nair, Salavat R. Aglyamov, and Kirill V. Larin. "Compressional Optical Coherence Elastography of the Cornea." Photonics 8, no. 4 (2021): 111. http://dx.doi.org/10.3390/photonics8040111.

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Assessing the biomechanical properties of the cornea is crucial for detecting the onset and progression of eye diseases. In this work, we demonstrate the application of compression-based optical coherence elastography (OCE) to measure the biomechanical properties of the cornea under various conditions, including validation in an in situ rabbit model and a demonstration of feasibility for in vivo measurements. Our results show a stark increase in the stiffness of the corneas as IOP was increased. Moreover, UV-A/riboflavin corneal collagen crosslinking (CXL) also dramatically increased the stiff
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8

Frentz, Markus, Miriam Goss, Martin Reim, and Norbert F. Schrage. "Repeated Exposure to Benzalkonium Chloride in the Ex Vivo Eye Irritation Test (EVEIT): Observation of Isolated Corneal Damage and Healing." Alternatives to Laboratory Animals 36, no. 1 (2008): 25–32. http://dx.doi.org/10.1177/026119290803600105.

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The prediction of side-effects is a key issue in the REACH initiative on chemicals, in the production of cosmetics and in the preclinical testing of drugs. A new ex vivo test for repeated substance application is presented, that is able to identify corrosive and irritant effects on the eye by using crucial endpoints, such as cellular and morphological damage, and healing characteristics. The test is intended to replace the Draize eye test and to improve the preclinical testing of drugs and chemicals that are likely to come into direct contact with the cornea. The Ex Vivo Eye Irritation Test (E
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9

Ong, Keith, and Leonard Ong. "Benzalkonium chloride corneal toxicity post-cataract surgery." Asian Journal of Ophthalmology 17, no. 1 (2020): 56–60. http://dx.doi.org/10.35119/asjoo.v17i1.620.

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Two patients with presumed benzalkonium chloride (BAK) corneal toxicity after routine cataract surgery are presented. Patient 1 had corneal stroma and Descemet’s membrane folds. Patient 2 had moderate superficial punctate epithelial erosions (SPEE). They were on Chlorsig, Maxidex, and Acular eye drops tds postoperatively. The corneas of these two patients improved when BAK was removed or minimized from the postoperative eye drop regimen. Two vials of 1 ml dexamethasone 4mg/ml for injection were added to Chlorsig 10 ml bottle to substitute for Maxidex eye drops.
 BAK toxicity should be sus
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10

Bhayana, AmberAmar, Priyanka Prasad, and Anita Gupta. "Enantiomorphism - Cornea for a cornea, eye for an eye." Indian Journal of Ophthalmology 68, no. 6 (2020): 1181. http://dx.doi.org/10.4103/ijo.ijo_1785_19.

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11

Ahmedov, A. K., T. Z. Kerimov, Kh D. Tonaeva, B. E. Malygin, and S. A. Borzenok. "Technology for obtaining an ultrathin posterior lamellar corneal graft at the Eye Tissue Bank." Russian Journal of Transplantology and Artificial Organs 22, no. 3 (2020): 167–73. http://dx.doi.org/10.15825/1995-1191-2020-3-167-173.

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Objective: to develop technologies for preoperative preparation of the posterior lamellar corneal graft based on our own formulation of the preservation medium for optimal dehydration of the donor cornea and a technique for cutting out an ultrathin flap using an optimized method at the Eye Tissue Bank. Materials methods. In a series of experimental studies, we obtained data on the hydration level of cadaveric donor corneas that were preserved in various solutions at different observation periods. Using 16 corneas, analytical weighing and pachymetry were performed via optical coherence tomograp
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12

Alsmman Hassan, Alahmady Hamad, and Nesreen Gamal-Eldeen Abd Elhaliem Soliman. "Intrastromal Injection of China Painting Ink in Corneas of Male Rabbits: Clinical and Histological Study." Journal of Ophthalmology 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/8145926.

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Background. Many patients with corneal opacity or complicated cataract in blind eye ask for cosmoses. In this study we tried to investigate the staining of corneas of male rabbits by Rotring China painting ink and to study the histological changes.Method. 10 eyes of 10 male Baladi Egyptian rabbits were injected (0.1 mL) intrastromally in the cornea by the use of China painting ink (Rotring Tinta China) through insulin syringe (27-gauge needle) by single injection; clinical follow-up is for 6 months and lastly the rabbits were scarified and the stained eyes were enucleated for histological anal
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13

Hayes, Sally, Siân R. Morgan, and Keith M. Meek. "Keratoconus: cross-linking the window of the eye." Therapeutic Advances in Rare Disease 2 (January 2021): 263300402110035. http://dx.doi.org/10.1177/26330040211003573.

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Keratoconus is a condition in which the cornea progressively thins and weakens, leading to severe, irregular astigmatism and a significant reduction in quality of life. Although the precise cause of keratoconus is still not known, biochemical and structural studies indicate that overactive enzymes within the cornea break down the constituent proteins (collagen and proteoglycans) and cause the tissue to weaken. As the disease develops, collagen fibres slip past each other and are redistributed across the cornea, causing it to change shape. In recent years, it was discovered that the photochemic
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14

Bald, Matthew R., Christopher Stoeger, Joshua Galloway, Maolong Tang, Jeffrey Holiman, and David Huang. "Use of Fourier-Domain Optical Coherence Tomography to Evaluate Anterior Stromal Opacities in Donor Corneas." Journal of Ophthalmology 2013 (2013): 1–5. http://dx.doi.org/10.1155/2013/397680.

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Purpose. To evaluate Fourier-domain optical coherence tomography (FD-OCT) as an adjunct to traditional slit lamp examination of donor corneas with suspected Anterior Stromal Opacities.Methods. Seven corneas suspected of having anterior stromal opacities by slit lamp examination were evaluated with FD-OCT. Each cornea was evaluated to confirm the presence of opacity and, if present, the depth of opacity was measured.Results. The opacity depth ranged from 82 μm to 624 μm. The initial slit lamp impressions of five of the seven corneas were confirmed by OCT. In two corneas, the OCT findings were d
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15

Machetta, Federica, Antonio M. Fea, Alessandro G. Actis, Ugo de Sanctis, Paola Dalmasso, and Federico M. Grignolo. "In Vivo Confocal Microscopic Evaluation of Corneal Langerhans Cells in Dry Eye Patients§." Open Ophthalmology Journal 8, no. 1 (2014): 51–59. http://dx.doi.org/10.2174/1874364101408010051.

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Purpose. To assess inflammatory involvement of cornea in dry eye by means of confocal microscopy, evaluating the presence and distribution of Langherans cells (LCs). Methods: 98 eyes of 49 subjects were enrolled: 18 subjects affected by Sjögren Syndrome Dry Eye (SSDE), 17 with Non-Sjögren Syndrome Dry Eye (NSSDE), 14 healthy volunteeers. Dry eye symptoms, tear film, ocular surface damage and corneal confocal microscopy were analized. Results: A significant increase of LCs density was observed at sub-basal nerve plexus (SSDE = 79 cells/mm2 and NDE = 22 cells/mm2; p = 0,0031) and sub-epithelial
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16

Rajaiya, Jaya, Amrita Saha, Ashrafali M. Ismail, Xiaohong Zhou, Ting Su, and James Chodosh. "Adenovirus and the Cornea: More Than Meets the Eye." Viruses 13, no. 2 (2021): 293. http://dx.doi.org/10.3390/v13020293.

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Human adenoviruses cause disease at multiple mucosal sites, including the respiratory, gastrointestinal, and genitourinary tracts, and are common agents of conjunctivitis. One site of infection that has received sparse attention is the cornea, a transparent tissue and the window of the eye. While most adenovirus infections are self-limited, corneal inflammation (keratitis) due to adenovirus can persist or recur for months to years after infection, leading to reduced vision, discomfort, and light sensitivity. Topical corticosteroids effectively suppress late adenovirus keratitis but are associa
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17

Tian, Mingxia, Ping Ma, Guoying Mu, Lijing Chen, and Jie Feng. "Establishing a Porcine Eye Model for Manual Sub-Bowman Layer Photorefractive Keratomileusis." Journal of Ophthalmology 2020 (July 15, 2020): 1–6. http://dx.doi.org/10.1155/2020/9834760.

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Objective. To establish a porcine eye model for manual sub-Bowman layer photorefractive keratomileusis (SBPRK), which is a reformed surface ablation refractive surgery that results in preserving the corneal Bowman layer (BL). Methods. The SBPRK group consisted of eleven eyes of 8 healthy pigs with BL flaps by mechanical technique followed by laser ablation. Regarding the remaining 5 eyes, 3 random eyes had transepithelium photorefractive keratectomy (TransPRK) (the TransPRK group), while the other 2 eyes were untreated (the blank control group). All the pigs were followed up for 8 weeks. Slit-
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18

Avgitidou, Georgia, Sebastian Siebelmann, Bjoern Bachmann, Juergen Kohlhase, Ludwig M. Heindl, and Claus Cursiefen. "Brittle Cornea Syndrome: Case Report with Novel Mutation in thePRDM5Gene and Review of the Literature." Case Reports in Ophthalmological Medicine 2015 (2015): 1–5. http://dx.doi.org/10.1155/2015/637084.

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A 3-year-old boy presented with acute corneal hydrops on the left eye and spontaneous corneal rupture on the right eye. A diagnosis of brittle cornea syndrome was confirmed by molecular analysis. A novel mutation, the homozygous variant c.17T>G, p.V6G, was found in the gene for PR-domain-containing protein 5 (PRDM5) in exon 1. Brittle cornea syndrome is a rare connective tissue disease with typical ocular, auditory, musculoskeletal, and cutaneous disorders. Almost all patients suffer from declined vision due to corneal scarring, thinning, and rupture. The most common ophthalmologic findings
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19

Iglicki, Matias, Anat Loewenstein, Manuel Manera, et al. "Autologous Corneal Transplant from an Enucleated Fellow Eye for Choroidal Melanoma: A Case Report." Case Reports in Ophthalmology 11, no. 2 (2020): 181–88. http://dx.doi.org/10.1159/000507776.

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Background: To report a case of autologous corneal transplant in a patient with corneal leukoma and choroidal melanoma in the fellow eye. Case Presentation: A 56-year-old woman was complaining about decrease in vision in her left eye. The patient was on the waiting list for a corneal transplant on her right eye due to corneal leucoma after a previous herpes infection. The patient was diagnosed with choroidal melanoma in her left eye. Due to the tumor size (longitudinal diameter >10 mm; anterior-posterior diameter >16 mm) the patient decided to undergo enucleation, after being informed ab
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Storms, G., C. Naranjo, and M. Grauwels. "Concurrent squamous cell carcinoma and hemangiosarcoma in the cornea of a cat." Vlaams Diergeneeskundig Tijdschrift 85, no. 1 (2016): 31–35. http://dx.doi.org/10.21825/vdt.v85i1.16405.

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A 14-year-old, female, spayed Domestic Shorthair cat was presented for evaluation of a dark red mass occupying about 75% of the cornea of the left eye. Furthermore, the eye presented upper eyelid trichiasis, lower eyelid entropion and a marked symblepharon. The fellow eye presented upper eyelid trichiasis, lower eyelid entropion, extensive symblepharon and chronic stromal ulcerative keratitis. Based on the results of a corneal biopsy of the left eye, a corneal squamous cell carcinoma was diagnosed and an enucleation was performed subsequently. Histopathology of the globe revealed the presence
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Mobaraki, Mohammadmahdi, Madjid Soltani, Samaneh Zare Harofte, et al. "Biodegradable Nanoparticle for Cornea Drug Delivery: Focus Review." Pharmaceutics 12, no. 12 (2020): 1232. http://dx.doi.org/10.3390/pharmaceutics12121232.

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During recent decades, researchers all around the world have focused on the characteristic pros and cons of the different drug delivery systems for cornea tissue change for sense organs. The delivery of various drugs for cornea tissue is one of the most attractive and challenging activities for researchers in biomaterials, pharmacology, and ophthalmology. This method is so important for cornea wound healing because of the controllable release rate and enhancement in drug bioavailability. It should be noted that the delivery of various kinds of drugs into the different parts of the eye, especia
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Sozurakova, E. A., E. V. Gromakina, and V. G. Mozes. "Features of the Content of Cellular Messengers of Inflammation in Eye Injuries." Ophthalmology in Russia 17, no. 2 (2020): 181–87. http://dx.doi.org/10.18008/1816-5095-2020-2-181-187.

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Eye injury is one of the actual problems in modern ophthalmology. Penetrating wounds of the cornea are the most significant among all eye injuries. New data on the course of inflammation in corneal injury will allow us to predict the course of the post-traumatic period and improve treatment outcomes. The corneal immune privilege is a unique system of protecting one’s own tissues from damage caused by systemic immunity reactions, which is realized through several mechanisms. Modern research shows that healing from corneal injury is a complex cascade of cellular reactions, the understanding of w
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Shen, Yun-Zhi, Mi Xu, and Song Sun. "In Vivo Confocal Microscopy Observation of Cell and Nerve Density in Different Corneal Regions with Monocular Pterygium." Journal of Ophthalmology 2020 (March 23, 2020): 1–7. http://dx.doi.org/10.1155/2020/6506134.

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Purpose. To investigate the effects of pterygium on corneal cell and nerve density in patients with unilateral pterygium using in vivo laser scanning confocal microscopy (LSCM). Methods. In this cross-sectional study, 24 patients with unilateral pterygium who were treated in the Department of Ophthalmology of the Second People’s Hospital of Wuxi City from April 2018 to July 2018 were analyzed. Each eye with pterygium and its fellow eye were imaged by LSCM. The density of basal corneal epithelial cells, anterior stromal cells, posterior stromal cells, dendritic cells, and endothelial cells in p
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Severinsky, Boris. "Silicone Hydrogel Miniscleral Contact Lenses after Corneal Collagen Crosslinking for Post-LASIK Keratoectasia." International Journal of Keratoconus and Ectatic Corneal Diseases 3, no. 3 (2014): 127–29. http://dx.doi.org/10.5005/jp-journals-10025-1092.

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ABSTRACT Purpose To report successful visual rehabilitation of post refractive surgery keratoectasia shortly after corneal collage crosslinking (CXL) procedure achieved with silicone hydrogel mini-scleral (SHmS) contact lens. Materials and methods A 29-year-old woman attended to our clinic with complaints on decreased vision in her left eye. Twelve years earlier she underwent bilateral laser-assisted in situ keratomileusis (LASIK) procedure for myopia correction. Corneal topography revealed bilateral central keratoectasia with maximal keratometry values of 55.4 Diopter (D) for her right eye an
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Toffoletto, Nadia, Anuj Chauhan, Carmen Alvarez-Lorenzo, Benilde Saramago, and Ana Paula Serro. "Asymmetry in Drug Permeability through the Cornea." Pharmaceutics 13, no. 5 (2021): 694. http://dx.doi.org/10.3390/pharmaceutics13050694.

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The permeability through the cornea determines the ability of a drug or any topically applied compound to cross the tissue and reach the intraocular area. Most of the permeability values found in the literature are obtained considering topical drug formulations, and therefore, refer to the drug permeability inward the eye. However, due to the asymmetry of the corneal tissue, outward drug permeability constitutes a more meaningful parameter when dealing with intraocular drug-delivery systems (i.e., drug-loaded intraocular lenses, intraocular implants or injections). Herein, the permeability coe
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26

Pozdeeva, N. A., I. L. Kulikova, M. V. Sinicin, and A. E. Terentieva. "Induced Astigmatism and Concomitant High Myopia Correction with Femtosecond Laser-assisted Intrastromal MyoRing Implantation." Fyodorov journal of ophthalmic surgery, no. 4 (December 29, 2020): 73–76. http://dx.doi.org/10.25276/0235-4160-2020-4-73-76.

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Purpose. Analysis of the results of astigmatism correction after penetrating keratoplasty and concomitant high myopia using the MyoRing ring implantation, clinical case as an example. Material and methods. Patient G., 51 years old, underwent surgery to correct astigmatism and concomitant high myopia. MyoRing was implanted in the right eye within corneal transplant limits using femtosecond laser-assisted intrastromal MyoRing implantation. Before the surgery uncorrected visual acuity at the operated eye was 0.01; corrected visual acuity 0.06; spherical component of refraction was (–)6.0 D, cylin
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27

Guérin, Louis-Philippe, Gaëtan Le-Bel, Pascale Desjardins, et al. "The Human Tissue-Engineered Cornea (hTEC): Recent Progress." International Journal of Molecular Sciences 22, no. 3 (2021): 1291. http://dx.doi.org/10.3390/ijms22031291.

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Each day, about 2000 U.S. workers have a job-related eye injury requiring medical treatment. Corneal diseases are the fifth cause of blindness worldwide. Most of these diseases can be cured using one form or another of corneal transplantation, which is the most successful transplantation in humans. In 2012, it was estimated that 12.7 million people were waiting for a corneal transplantation worldwide. Unfortunately, only 1 in 70 patients received a corneal graft that same year. In order to provide alternatives to the shortage of graftable corneas, considerable progress has been achieved in the
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Hori, Junko, Tomoyuki Kunishige, and Yuji Nakano. "Immune Checkpoints Contribute Corneal Immune Privilege: Implications for Dry Eye Associated with Checkpoint Inhibitors." International Journal of Molecular Sciences 21, no. 11 (2020): 3962. http://dx.doi.org/10.3390/ijms21113962.

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The eye is provided with immune protection against pathogens in a manner that greatly reduces the threat of inflammation-induced vision loss. Immune-mediated inflammation and allograft rejection are greatly reduced in the eye, a phenomenon called ‘immune privilege’. Corneal tissue has inherent immune privilege properties with underlying three mechanisms: (1) anatomical, cellular, and molecular barriers in the cornea; (2) an immunosuppressive microenvironment; and (3) tolerance related to regulatory T cells and anterior chamber-associated immune deviation. This review describes the molecular me
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Kling, Sabine, Imran B. Akca, Ernest W. Chang, et al. "Numerical model of optical coherence tomographic vibrography imaging to estimate corneal biomechanical properties." Journal of The Royal Society Interface 11, no. 101 (2014): 20140920. http://dx.doi.org/10.1098/rsif.2014.0920.

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Most techniques measuring corneal biomechanics in vivo are biased by side factors. We demonstrate the ability of optical coherence tomographic (OCT) vibrography to determine corneal material parameters, while reducing current prevalent restrictions of other techniques (such as intraocular pressure (IOP) and thickness dependency). Modal analysis was performed in a finite-element (FE) model to study the oscillation response in isolated thin corneal flaps/eye globes and to analyse the dependency of the frequency response function on: corneal elasticity, viscoelasticity, geometry (thickness and cu
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Mohamed-Noriega, Karim, Karla Butrón-Valdez, Jeronimo Vazquez-Galvan, Jibran Mohamed-Noriega, Humberto Cavazos-Adame, and Jesús Mohamed-Hamsho. "Corneal Melting after Collagen Cross-Linking for Keratoconus in a Thin Cornea of a Diabetic Patient Treated with Topical Nepafenac: A Case Report with a Literature Review." Case Reports in Ophthalmology 7, no. 1 (2016): 119–24. http://dx.doi.org/10.1159/000444437.

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Purpose: To report the case of a 50-year-old woman with diabetes that presented with corneal melting and perforation 6 weeks after collagen cross-linking (CxL) for keratoconus (KC) and postoperative use of nepafenac eye drops, a nonsteroidal anti-inflammatory drug (NSAID). Methods: This is a case report of a patient with diabetes, KC and a thin cornea that had undergone left eye corneal CxL at a different hospital followed by postoperative use of nepafenac eye drops for 6 weeks. Results: The patient presented for the first time to our clinic with left corneal melting, perforation and iris prol
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Pereira Cruz, Giovanna Karinny, Marcos Antonio Ferreira Júnior, Oleci Pereira Frota, et al. "Cornea donation process and tissue quality for transplantation." PLOS ONE 16, no. 4 (2021): e0249927. http://dx.doi.org/10.1371/journal.pone.0249927.

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Introduction The quality of the corneal tissue can be influenced by several factors inherent to the recipient, donor, and to the donation and transplantation process. The donated corneal tissue can be classified by its quality as excellent, good, regular, bad, or unacceptable for transplantation, evaluating it in a slit lamp. Objective To analyze the relationship between the clinical and sociodemographic variables of the donors and the donation process and the classification of the quality of the corneal tissue collected for transplantation. Methods This is an epidemiologic study, retrospectiv
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Lee, Dongyoung, Gyu Le Han, Dong Hui Lim, and Tae Young Chung. "Case Report of Brown McLean Syndrome." Journal of the Korean Ophthalmological Society 62, no. 8 (2021): 1135–40. http://dx.doi.org/10.3341/jkos.2021.62.8.1135.

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Purpose: To report two rare cases of Brown McLean syndrome after cataract surgery in a patient with aphakia.Case summary: (Case 1) A 54-year-old woman with Marfan’s syndrome who had aphakia and peripheral corneal edema after left eye cataract surgery 4 years ago. The patient had an elevated lesion in the peripheral cornea without involving the central cornea, and had symptoms of pain, irritation and tearing. Specular microscopy showed normal endothelial cell density and morphology in the edematous cornea. The peripheral corneal edema improved after use of antibiotics, autoserum eyedrops and 5%
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Menzel-Severing, Johannes, Sabine Salla, and Gerd Geerling. "Eye Banks: Future Perspectives." Klinische Monatsblätter für Augenheilkunde 238, no. 06 (2021): 674–78. http://dx.doi.org/10.1055/a-1478-4277.

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AbstractTechnological progress and societal change are transforming medicine, and cornea banks are no exception. New infectiological factors, statutory requirements, management concepts, globalisation and digitalisation are also influencing how such facilities will operate in the future. The goal of providing high quality material to patients with corneal disease remains unaltered. The present article seeks to shed light on the type of material this will involve and under what circumstances it is to be obtained.
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Kiliç, Kaya, Deniz Konya, Özlem Kurtkaya, Aydin Sav, M. Necmettin Pamir, and Türker Kiliç. "Inhibition of angiogenesis induced by cerebral arteriovenous malformations using Gamma Knife irradiation." Journal of Neurosurgery 106, no. 3 (2007): 463–69. http://dx.doi.org/10.3171/jns.2007.106.3.463.

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Object The authors studied the effect of Gamma Knife irradiation on angiogenesis induced by cerebral arteriovenous malformation (AVM) tissues implanted in the corneas of rats. Methods Ten AVM specimens obtained from tissue resections performed at Marmara University between 1998 and 2004 were used. A uniform amount of tissue was implanted into the micropocket between the two epithelial layers of the cornea. Gamma Knife irradiation was applied with dose prescriptions of 15 or 30 Gy to one cornea at 100% iso-dose. Dosing was adjusted so that the implanted cornea of one eye received 1.5 Gy when 15
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Patel, Dhaval, Radhika Tandon, Anita Ganger, Aarti Vij, Sanjeev Lalwani, and Adarsh Kumar. "Study of death to preservation time and its impact on utilisation of donor corneas." Tropical Doctor 47, no. 4 (2017): 365–70. http://dx.doi.org/10.1177/0049475517713406.

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To evaluate the impact of death-to-preservation time (DPT) on effective utilisation of donor corneas. In a prospective observational study conducted at our tertiary eye centre, donated corneas received over a 15-month period from November 2011 to January 2013 were evaluated. Donor age, donor refrigeration (done or not), DPT, endothelial cell density (ECD), corneal grading, clinical utilisation and surgical outcome after graft transplantation were noted. To analyse the impact of different DPT on donor cornea transplantation, primary outcome measures (corneal grading and endothelial cell density
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Lenart, SB, and JA Garrity. "Eye care for patients receiving neuromuscular blocking agents or propofol during mechanical ventilation." American Journal of Critical Care 9, no. 3 (2000): 188–91. http://dx.doi.org/10.4037/ajcc2000.9.3.188.

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BACKGROUND: The presence of a corneal reflex and the ability to maintain eye closure are instrumental in protecting the cornea. Use of neuromuscular blocking agents or propofol can result in impaired eyelid closure and loss of corneal reflex, leading to corneal exposure. The cornea is then at risk for drying, infection, and scarring, which may lead to permanent visual loss. OBJECTIVES: To determine whether applying artificial tear ointment to the eyes of paralyzed or heavily sedated patients receiving mechanical ventilation decreases the prevalence of exposure keratitis more than does passive
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Eleiwa, Taher, Mariam Raheem, Nimesh A. Patel, Audina M. Berrocal, Alana Grajewski, and Mohamed Abou Shousha. "Case Series of Brittle Cornea Syndrome." Case Reports in Ophthalmological Medicine 2020 (March 20, 2020): 1–6. http://dx.doi.org/10.1155/2020/4381273.

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Purpose. This case series demonstrate diagnostic features, treatment options, and challenges for Brittle Cornea Syndrome. Observations. Three cases presented with bluish sclera and extremely thin cornea. Genetic workup was performed and confirmed the diagnosis of Brittle Cornea Syndrome, a rare autosomal recessive disorder characterized by corneal thinning and blue sclera. Case 1 was a 4-year-old boy who developed cataract and glaucoma after undergoing right tectonic penetrating keratoplasty (PK) secondary to a spontaneous corneal rupture. Glaucoma was controlled medically. Later, the kid unde
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Raj, Anuradha, Renu Dhasmana, and Harsh Bahadur. "Unilateral lattice corneal dystrophy in a young female: A unique case report." Nepalese Journal of Ophthalmology 9, no. 1 (2017): 66–69. http://dx.doi.org/10.3126/nepjoph.v9i1.17537.

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Background: Unilateral lattice corneal dystrophy is a rare entity. Objective: To highlight the evidence of unilateral lattice corneal dystrophy in a young female. Case: A young 28 years old female presented to the outpatient department of Ophthalmology with slowly progressive diminution of vision in left eye for one month. On ophthalmological examination best corrected visual acuity (BCVA) was 20/20 and 20/40 with refractive error of plano and -0.75D Cyl @30 for right and left eye respectively. Ocular examination of right eye was unremarkable. On slit lamp examination, left eye showed multiple
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39

Mishra, S. K., G. S. Shrestha, P. Dhungel, and B. Aryal. "Visual outcome on Fitting Rose-K2 XL lens in a case with Terrien’s marginal degeneration." Journal of Chitwan Medical College 4, no. 4 (2015): 49–51. http://dx.doi.org/10.3126/jcmc.v4i4.11974.

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Terrien’s marginal degeneration is an uncommon disease of the peripheral cornea occurring at any age that results in corneal thinning causing corneal irregular astigmatism. RoseK2 XL lens has an aspheric optical zone and employed in the fitting of irregular corneas for vision and comfort while maintaining corneal health. Rose K2 XL lens was fitted in a 17 year female presented to Contact lens clinic of B.P. Koirala Lions Center for Ophthalmic Studies, Kathmandu having RE Terrien’s marginal degeneration. Her presenting visual acuity was 6/60 in right eye and 6/6 in left eye with best subjective
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Sacchetti, Marta, Paolo Rama, Alice Bruscolini, and Alessandro Lambiase. "Limbal Stem Cell Transplantation: Clinical Results, Limits, and Perspectives." Stem Cells International 2018 (October 11, 2018): 1–12. http://dx.doi.org/10.1155/2018/8086269.

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Limbal stem cell deficiency (LSCD) is a clinical condition characterized by damage of cornea limbal stem cells, which results in an impairment of corneal epithelium turnover and in an invasion of the cornea by the conjunctival epithelium. In these patients, the conjunctivalization of the cornea is associated with visual impairment and cornea transplantation has poor prognosis for recurrence of the conjunctivalization. Current treatments of LSCD are aimed at replacing the damaged corneal stem cells in order to restore a healthy corneal epithelium. The autotransplantation of limbal tissue from t
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Özalp, Onur, Eray Atalay, and Nilgün Yıldırım. "A Case of True Superior Keratoconus Confirmed Using Multiple Imaging Modalities." International Journal of Keratoconus and Ectatic Corneal Diseases 8, no. 2 (2019): 43–45. http://dx.doi.org/10.5005/jp-journals-10025-1180.

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ABSTRACT Aim To report an unusual case of a newly diagnosed bilateral superior keratoconus in an elderly patient. Background We report a case of bilateral superior keratoconus in a 64-year-old woman who was diagnosed after having presented with hydrops in one eye. Case description Uncorrected visual acuity was counting fingers from 3 and 1 meter for the right and left eyes, respectively. A superiorly located deep stromal scar and chronic corneal edema consistent with a diagnosis of corneal hydrops were noted for the left eye. Although the cornea was clear, there was superior corneal protrusion
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Erdinest, Nir, Ortal Palatchi Sabag, Naomi London, and Abraham Solomon. "Quadrant Asymmetric Design Contact Lens for Visual Rehabilitation after Eye Trauma." Case Reports in Ophthalmology 12, no. 2 (2021): 330–36. http://dx.doi.org/10.1159/000512505.

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The purpose of this case report is to demonstrate the efficacy of an asymmetric peripheral design scleral contact lens in a case of highly irregular corneal-scleral pattern due to trauma. A 63-year-old patient was involved in a jeep accident which caused a partial-thickness penetrating injury to the peripheral cornea of his left eye. The subsequent corneal irregularity extended beyond the limbus into the sclera which made it difficult to stabilize a contact lens. A quadrant specific peripheral curve (quadrant asymmetric periphery) scleral contact lens successfully resulted in improved comfort
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Teixeira, Roseli Borges, Paulo Sergio de Moraes Barros, and Maria Cristina Martins. "Effects of topical 2% cyclosporine A on the corneas of dogs subjected to lamellar keratoplasty with a graft of equine pericardium preserved in glycerin: clinical and morphological evaluation." Ciência Rural 34, no. 1 (2004): 131–38. http://dx.doi.org/10.1590/s0103-84782004000100020.

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The effects of topical 2% cyclosporine A on the cornea of dogs subjected to experimental lamellar keratoplasty with an equine pericardial graft were evaluated. Ten dogs were grouped to be evaluated 3, 7, 15, 30 and 60 days after surgery. Animals received bilateral grafts followed by the application of a 2% cyclosporine A ointment on the left eye (treated eye) and the ointment base on the right eye (control eye) twice a day. The ophthalmic evaluation showed profound bilateral blepharospasm, photophobia and a mucous secretion until the 7th day after surgery; corneal vascularization starting in t
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Zorn-Kruppa, Michaela, Svitlana Tykhonova, Gazanfer Belge, Jürgen Bednarz, Horst A. Diehl, and Maria Engelke. "A Human Corneal Equivalent Constructed from SV40-immortalised Corneal Cell Lines." Alternatives to Laboratory Animals 33, no. 1 (2005): 37–45. http://dx.doi.org/10.1177/026119290503300107.

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Within the last decade, extensive research in the field of tissue and organ engineering has focused on the development of in vitro models of the cornea. The use of organotypic, three-dimensional corneal equivalents has several advantages over simple monolayer cultures. The aim of this study was to develop a corneal equivalent model composed of the same cell types as in the natural human tissue, but by using immortalised cell lines to ensure reproducibility and to minimise product variation. We report our success in the establishment of an SV40-immortalised human corneal keratocyte cell line (d
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Nukala, Naveen, Rajeev Reddy Pappuru, and Vivek Pravin Dave. "Endoscopy-assisted removal of angle foreign body presenting as persistent localised corneal oedema." BMJ Case Reports 13, no. 4 (2020): e233419. http://dx.doi.org/10.1136/bcr-2019-233419.

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A 20-year-old man presented to us with injury to the left eye by a glass bulb 3 weeks ago. The acute injury resolved with a peculiar residual localised corneal oedema in the inferior one-third of the cornea . This localised oedema in absence of any evidence of a localised visible injury to the cornea indicated towards a possible retained foreign body. The foreign body visibility was equivocal on gonioscopy. Subsequently via a limbal incision, an endoscope was introduced into the anterior chamber. The endoscopic view revealed the glass foreign body lodged into the inferior angle of the eye whic
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Koprowski, Robert, and Sławomir Wilczyński. "Corneal Vibrations during Intraocular Pressure Measurement with an Air-Puff Method." Journal of Healthcare Engineering 2018 (2018): 1–13. http://dx.doi.org/10.1155/2018/5705749.

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Introduction. The paper presents a commentary on the method of analysis of corneal vibrations occurring during eye pressure measurements with air-puff tonometers, for example, Corvis. The presented definition and measurement method allow for the analysis of image sequences of eye responses—cornea deformation. In particular, the outer corneal contour and sclera fragments are analysed, and 3D reconstruction is performed. Methods. On this basis, well-known parameters such as eyeball reaction or corneal response are determined. The next steps of analysis allow for automatic and reproducible separa
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BABRAUSKIENĖ, VIDA, JUDITA ŽYMANTIENĖ, ALBINA ANIULIENĖ, VIDA JUOZAITIENĖ, SNIEGUOLĖ MALAKAUSKIENĖ, and INGRIDA ALIONIENĖ J. "Comparative morphological evaluation of animal corneal parameters." Medycyna Weterynaryjna 74, no. 1 (2018): 6010–2018. http://dx.doi.org/10.21521/mw.6010.

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The purpose of this study was to broaden the basic knowledge of corneal morphological structures in pigs, cows and rabbits and to find morphological and histological differences in the constituent corneal structures. After slaughter, corneal samples of 24 animals, including cows, pigs and rabbits, were investigated. Forty-eight eyeballs (n=48) of 8 pigs, 8 cows and 8 rabbits were used for this study. Central corneal thickness (CCT) values in cows were higher than those in pigs (P < 0.001) and rabbits. In rabbits, CCT, as a percentage of the eye axis length, was 55.03% greater than in co
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48

Varkoly, Gréta, János Bencze, Tibor Hortobágyi, and László Módis. "A cornealis sebgyógyulás és az extracelluláris mátrix." Orvosi Hetilap 157, no. 25 (2016): 995–99. http://dx.doi.org/10.1556/650.2016.30475.

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The cornea is the first refractive element of the eye. The transparency of the cornea results from the regularly arranged collagen fibrils, forming lamellar structure and the leucin rich proteoglycans, which make interactions between the fibrils. The adult cornea consists mainly of fibril-forming collagens. The cornea has less amount of fibril associated and non-fibrillar collagens. The main proteoglycans of the cornea are keratan-sulfate proteoglycans and it also contains dermatan-sulfate proteoglycans. Disorders of the proteoglycan synthesis lead to the disruption of the unique pattern and r
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Ivachev, E. A., E. V. Anisimova, and I. P. Denisova. "Results of Cataract Extraction in Patients with Corneal Opacity." Ophthalmology in Russia 16, no. 2 (2019): 179–84. http://dx.doi.org/10.18008/1816-5095-2019-2-179-184.

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Purpose. To evaluate the effectiveness of cataract extraction in patients with varying degrees of corneal opacity.Patients and methods. We performed cataract extraction with implantation of the intraocular lenses of 14 eyes (9 patients) with varying degree of corneal opacity. The causes of corneal opacities were: keratitis in anamnesis — 6 cases, the result of wearing soft contact lenses — 2 eyes, eye injury — 2, the outcome of dermatitis of unspecified genesis with eye damage — 3, perforation of the corneal ulcer — 1 case. In 9 eyes, opacity of the cornea occupied the optic part of the cornea
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50

Yi, Qiong, and Wen-jin Zou. "The Wound Healing Effect of Doxycycline after Corneal Alkali Burn in Rats." Journal of Ophthalmology 2019 (October 10, 2019): 1–10. http://dx.doi.org/10.1155/2019/5168652.

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Purpose. To evaluate the wound healing effect of doxycycline and its underlying mechanisms in a rat model of corneal alkali burn. Methods. Male SD rats were administered 1.0 N NaOH in the right cornea for 25 seconds and randomly divided into the doxycycline group and the control group, with 84 rats in each group. 1.0 g·L−1 doxycycline eye drops (doxycycline group) or vehicle (control group) was topically instilled onto the rat cornea after chemical injury. Three days, 7 days, and 14 days after alkali burn, microscopy was used to observe corneal wound healing by fluorescein staining and the deg
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