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Dissertations / Theses on the topic 'Corneal and Stromal Cells'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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1

Nili, Ahmadabadi Elham. "Development of a novel mesenchymal stromal cell (MSC) therapy for repairing the cornea." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/122897/1/Elham_Nili%20Ahmadabadi_Thesis.pdf.

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This thesis has produced advances in our understanding of the biology and potential clinical application of stem cells to aid the treatment of patients with severe eye injuries. This research evaluated the therapeutic potential of a stem cell (called Mesenchymal Stromal Cells (MSCs)) isolated from the peripheral margin of the cornea, known as the limbus. Firstly, a method for routinely isolation and propagation of human limbal MSCs was optimized. Subsequently, the performance of those cells on a silk fibroin membrane was examined.
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Kulikovska, Marina. "Corneal stromal cell responses to traumatic wounds and topical treatments." Doctoral thesis, Linköpings universitet, Avdelningen för neuro- och inflammationsvetenskap, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-114700.

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Background. The cornea has unique anatomic, cellular, molecular, and functional features that lead to important mechanistic differences in the process of repair in comparison with what occurs in skin and other organs. The first observable stromal response in corneal wound healing is keratocyte apoptosis. Shortly thereafter, remaining keratocytes in adjacent areas obtain a fibroblastic phenotype and begin to proliferate and to migrate, transforming into myofibroblasts, a phenotype associated with remodeling of stromal collagen. Return to normalcy following wound healing includes elimination of
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3

Al, Abdulsalam Najla Khaled S. "Evaluation of silk fibroin as a scaffold for cultured corneal endothelial cell implants." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/122231/1/Najla%20Khaled%20S_Al%20Abdulsalam_Thesis.pdf.

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Corneal transplants are a safe and effective treatment for corneal disease, but are hampered by the limited supply and quality of donor tissue. The goal of this project was therefore to evaluate the use of membranes prepared from silk protein as a scaffold on which to grow corneal tissue substitutes in the laboratory from corneal endothelial cells.
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4

Forest, Fabien. "Bioengineering de greffons endothéliaux : versant cellulaire." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSES067.

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La cécité d’origine cornéenne est Ia deuxième cause de cécité dans le monde. Son traitement de choix est la kératoplastie. ll est aujourd’hui nécessaire de réfléchir à de nouvelles solutions pour remplacer la kératoplastie dans sa forme actuelle qui bien que satisfaisante, n’est pas totalement parfaite. En effet, les techniques actuelles de kératoplastie utilisent une allogreffe. Le greffon va subir chez le donneur une diminution de la densité des cellules endothéliales (CE) du greffon au fil du temps. Ce travail présente successivement les solutions abordées par le BiiGC pour produire des CE
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Bray, Laura Jane. "Evaluation of fibroin-based scaffolds for ocular tissue reconstruction." Thesis, Queensland University of Technology, 2012. https://eprints.qut.edu.au/52665/1/Laura_Bray_Thesis.pdf.

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The epithelium of the corneolimbus contains stem cells for regenerating the corneal epithelium. Diseases and injuries affecting the limbus can lead to a condition known as limbal stem cell deficiency (LSCD), which results in loss of the corneal epithelium, and subsequent chronic inflammation and scarring of the ocular surface. Advances in the treatment of LSCD have been achieved through use of cultured human limbal epithelial (HLE) grafts to restore epithelial stem cells of the ocular surface. These epithelial grafts are usually produced by the ex vivo expansion of HLE cells on human donor amn
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6

Ghoubay-Benalloua, Djida. "Traitement des pathologies cornéennes par thérapie cellulaire et bioingénierie tissulaire." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066445/document.

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Les agressions graves de la surface oculaire peuvent se compliquer d'ulcérations cornéennes épithéliales, de néovascularisation, d'opacification et d'inflammation chroniques, échappant à tout traitement médical. Les progrès dans la compréhension de la physiologie du renouvèlement de l'épithélium et du stroma cornéen ont permis d'introduire une approche thérapeutique, la greffe de cellules souches. L'objectif de notre étude est d'apporter une source de cellules souches cornéennes par thérapie cellulaire afin de restituer une fonction épithéliale et stromale permettant l'obtention d'une cornée c
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7

Etheredge, LaTia Shaquan. "The Effect of Growth Factors on the Corneal Stroma Extracellular Matrix Production by Keratocytes." [Tampa, Fla] : University of South Florida, 2009. http://purl.fcla.edu/usf/dc/et/SFE0003238.

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8

Doutch, James John. "Modelling corneal transparency with reference to stromal architecture." Thesis, Cardiff University, 2009. http://orca.cf.ac.uk/54795/.

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The arrangement of corneal collagen fibrils within lamellae was investigated by comparing fibril positions obtained from electron microscopy with distorted hexagonal, quasi-random and aperiodic arrays. By calculating the wavelength dependence and Fourier transforms of these various arrays it was determined that an aperiodic array based on the sunflower seed head is the most compatible with corneal ultrastructure. An investigation of corneal light scattering away from the central axis was undertaken for the first time. Experimentally it was shown that corneal transmission decreases peripherally
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9

Ahearne, Mark. "Mechanical characterisation of cornea and corneal stromal equivalents." Thesis, Keele University, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.573762.

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10

Wilson, Samantha Louise. "Optimisation and characterisation of human corneal stromal models." Thesis, Keele University, 2013. http://eprints.keele.ac.uk/202/.

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The native corneal structure is highly organised and unified in architecture with structural and functional integration which mediates its transparency and mechanical strength. Two of the most demanding challenges in corneal tissue engineering are the replication of the native corneal stromal architecture and the preservation of stromal cell phenotype which prevents scar-like tissue formation. A concerted effort in this thesis has been devoted to the generation of a functional human corneal stromal model by the manipulation of chemical, topographical and cellular cues. To achieve this, previou
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11

Ainscough, Sarah Louise. "Improved strategies for the cultivation of human limbal epithelial (HLE) grafts." Thesis, Queensland University of Technology, 2008. https://eprints.qut.edu.au/18575/1/Sarah%20Ainscough%20Thesis.pdf.

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The limbal stem cell population is located in the limbal junctional zone between the cornea and the conjunctiva, and is responsible for maintaining the corneal epithelium. Damage to the limbal stem cell population results in a condition known as limbal stem cell deficiency (LSCD), which is characterised by conjunctivalisation of the cornea, visual impairment and persistent irritation. To treat LSCD, an alternative source of human limbal epithelial (HLE) cells must be transplanted back onto the diseased cornea. Limbal tissue grafts have had a moderate degree of success. However, autologous graf
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12

Ainscough, Sarah Louise. "Improved strategies for the cultivation of human limbal epithelial (HLE) grafts." Queensland University of Technology, 2008. http://eprints.qut.edu.au/18575/.

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The limbal stem cell population is located in the limbal junctional zone between the cornea and the conjunctiva, and is responsible for maintaining the corneal epithelium. Damage to the limbal stem cell population results in a condition known as limbal stem cell deficiency (LSCD), which is characterised by conjunctivalisation of the cornea, visual impairment and persistent irritation. To treat LSCD, an alternative source of human limbal epithelial (HLE) cells must be transplanted back onto the diseased cornea. Limbal tissue grafts have had a moderate degree of success. However, autologous graf
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13

Hemmavanh, Chinda. "Regulatory Roles of FACIT Collagens XII and XIV in Cornea Stromal and Endothelial Development and Function." Scholar Commons, 2014. https://scholarcommons.usf.edu/etd/5038.

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Purpose: Corneal transparency depends upon the precise organization of corneal stromal extracellular matrix and corneal endothelial function. Stromal structure and extracellular matrix organization is responsible for proper refraction of light into the eye. The corneal endothelium is responsible for pumping excess fluid out of the cornea, effectively maintaining corneal hydration and thickness. Corneal transplantation is the current form of treatment for corneal endothelial and stromal dystrophies. The mechanisms controlling stromal collagen fibril packing and organization into orthogonal laye
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14

Armstrong, David James. "The role of the thrombospondins in modulation of corneal stromal wound healing." Thesis, University of Liverpool, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400305.

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15

Beecher, Nicola. "Role of keratan sulphate proteoglycans in the maintenance of mouse corneal stromal ultrastructure." Thesis, Cardiff University, 2006. http://orca.cf.ac.uk/56044/.

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The cornea is a remarkable connective tissue that is transparent to visible light as a consequence of the regularly arranged, uniformly-sized collagen fibrils that constitute it. Evidence suggests that this intricate collagen fibril architecture is maintained by the presence of keratan sulphate-carrying proteoglycans (KSPGs) within the corneal stroma. The KSPGs, lumican, keratocan, and mimecan are believed to be involved in the regulation of collagen fibril diameter and fibril spacing. KSPGs have recently been investigated using transgenic technology, which allows the manipulation of gene expr
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16

Luo, Jun 1969. "Marrow stromal cells for myocardial regeneration." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84055.

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Normal bone marrow is composed of hematopoietic and non-hematopoietic cells. The later have also been termed stromal cells or mesenchymal cells. These cells were originally thought to provide an appropriate matrix for hematopoietic cell development, but recent examination of these cell populations suggests a much broader spectrum of activity, including the generation of bone, cartilage, tendon, fat and muscles including myocardium.<br>Cellular cardiomyoplasty (CCM) based on adult bone marrow stromal cells (MSCs) is a novel means of augmenting cardiomyocyte number and contractile functio
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17

Fairclough, Marianne Elizabeth. "Diversity among monocyte derived stromal cells." Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/679/.

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Fibrocytes are monocyte-derived cells that morphologically look like fibroblasts, express both stromal and haematopoietic markers, and have been reported as being involved in wound healing and fibrosis. In-vitro derived fibrocytes can be differentiated in both serum-containing and serum-free environments and we wanted to study the relationship between these two fibrocytes; which potentially could be involved at different time points at a wound healing site. To investigate the relationship between serum-free and serum-containing derived fibrocytes monocytes were differentiated without serum. Wh
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18

Weber, Matthew Charles. "Engineering human bone marrow stromal cells." Case Western Reserve University School of Graduate Studies / OhioLINK, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=case1055867071.

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19

Chedrawy, Edgar George. "Cellular cardiomyoplasty using satellite cells and marrow stromal cells." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33729.

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Cellular cardiomyoplasty (cell therapy for myocardial regeneration) targets the basic pathophysiology of heart failure and represents a novel means of augmenting cardiomyocyte number and contractile function of the failing heart.<br>Chapter I reviews briefly current approaches to the treatment of heart failure. Cellular cardiomyoplasty is introduced and previous work conducted in our laboratory is reviewed. Chapter II focuses on the possibility of using marrow stromal cells as a cell source for cellular cardiomyoplasty. This proof-of-principle study was conducted in association with Dr. Jih-Sh
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20

Fung, Kwong-lam, and 馮廣林. "Chemoresistance induced by mesenchymal stromal cells on cancer cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/205639.

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Human mesenchymal stromal cells (hMSCs) are part of bone marrow micro-environment that supports hematopoiesis. However, hMSCs also enhance tumor progression and survival when they become part of the cancer micro-environment. I aimed to investigate the interaction between hMSCs and cancer cells during chemotherapy. Firstly, I studied the interaction between hMSCs and T-lineage acute lymphoblastic leukemia (T-ALL) cells under pegylated arginase I (BCT-100) treatment. Three T-ALL cell lines were sensitive to BCT-100 but not hMSCs. Conversely, hMSCs could partly protect all T-ALL cell lines fro
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21

Nie, Yingjie, and 聶瑛潔. "Defective dendritic cells and mesenchymal stromal cells in systemic lupus erythematosus and the potential of mesenchymal stromal cells ascell-therapy." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43278681.

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22

Chan, Giulia. "Regulation of viability in corneal endothelial cells." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1444592/.

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The major cause of corneal opacity and resultant visual loss is a critical decrease in corneal endothelial cell density. Due to the fact that corneal endothelial cells do not generally proliferate, cell densities gradually decrease in the corneal endothelium with age. Before we can begin to aid patients with decreasing endothelial cell densities, by inhibiting cell death or stimulating cell proliferation, it is necessary to understand the basic cell signalling that underlies these processes. As human tissue is difficult to obtain, a representative animal model of corneal endothelium was devise
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23

Nie, Yingjie. "Defective dendritic cells and mesenchymal stromal cells in systemic lupus erythematosus and the potential of mesenchymal stromal cells as cell-therapy." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43278681.

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24

Yoshida, Atsuhiro. "Adipose Tissue-Derived Stromal Cells Protect Hair Cells From Aminoglycoside." Kyoto University, 2012. http://hdl.handle.net/2433/157458.

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25

Liu, Hao. "Dendritic cell development directed by stromal cells." Thesis, University of York, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.516409.

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26

PISCHIUTTA, FRANCESCA. "Mesenchymal stromal cells for traumatic brain injury." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/52353.

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The multiple pathological cascades activated after traumatic brain injury (TBI) and their extended nature offer the possibility for therapeutic interventions possibly affecting multiple injury mechanisms simultaneously. Mesenchymal stromal cell (MSC) therapy matches this need, being a bioreactor of a variety of molecules able to interact and modify the injured brain microenvironment. Compared to autologous MSCs, bank stored GMP-graded allogenic MSCs appear to be a realistic choice for TBI in a translational perspective, due to the need of delivering cell therapy in the acute phase of the path
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27

Binti, Kamarudin Taty Anna. "Differentiation of human pluripotent stem cells into corneal epithelial like cells." Thesis, University of Newcastle upon Tyne, 2018. http://hdl.handle.net/10443/4182.

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Cornea is the clear outermost protective layer of the eye which enables transmission of light onto the retina. The corneal epithelium is regenerated by limbal stem cells (LSCs), whose loss/dysfunction results in limbal stem cell deficiency (LSCD). Transplantations of ex vivo expanded autologous LSCs from patient's healthy eye onto the affected eye have provided a successful treatment for unilateral LSCD. This however is not applicable to patient with total bilateral LSCD, whose both eyes are affected. This thesis investigated the potential of human induced-pluripotent stem cell (hiPSCs) to dif
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Rajendran, Vijayalakshmi. "Role of mesenchymal stem cells and collagen-based corneal equivalents in restoring corneal graft transparency." Thesis, University of Aberdeen, 2016. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=232053.

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29

Kono, Tomoya. "Differentiation of lymphatic endothelial cells from embryonic stem cells on OP9 stromal cells." Kyoto University, 2008. http://hdl.handle.net/2433/135863.

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30

Scarpa, Fabio. "Automatyc analysis of confocal images of the cornea." Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3425676.

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This thesis deals with the automatic analysis of confocal images of the cornea, and with the automatic estimation of clinical parameters. Corneal diseases and dystrophies (dry-eye, keratoconus, conjunctivitis, herpes keratitis, lattice dystrophy, etc.) affect vision in widely differing ways. Some cause severe visual impairment, while a few cause no vision problems and are discovered during an eye examination. Other dystrophies may cause repeated episodes of pain without leading to permanent loss of vision. Corneal structures are very sensitive to corneal pathologies: nerve fibers, keratocy
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31

Tsui, Yat-ping, and 徐軼冰. "Derivation of oligodendrocyte precursor cells from adult bone marrow stromal cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/197485.

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Myelin is essential for neuronal survival and maintenance of normal functions of the nervous system. Demyelinating disorders are debilitating and are often associated with failure of resident oligodendrocyte precursor cells (OPCs) to differentiate into mature, myelinating oligodendrocytes. Derivation of OPCs, from a safe source that evades ethical issues offers a solution to remyelination therapy. We therefore hypothesized that bone marrow stromal cells (BMSCs) harbour neural progenitor cells at a pre-commitment stage and that in vitro conditions can be exploited to direct differentiation of t
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32

Machens, Matthias. "The outcome of corneal grafting and patients with stromal keratitis of herpetic and non-herpetic origin /." Bern : [s.n.], 2003. http://www.stub.unibe.ch/html/haupt/datenbanken/diss/bestell.html.

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33

Pasanen, I. (Ilkka). "Stromal cells of mesenchymal origin in breast cancer." Doctoral thesis, Oulun yliopisto, 2017. http://urn.fi/urn:isbn:9789526215587.

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Abstract Breast cancer, the most common cancer in women in Finland; its prognosis varies from very good to poor. During the last two decades, mesenchymal stromal cells, carcinoma-associated fibroblasts and normal fibroblasts of the breast have been investigated in the context of breast carcinomas because of their presence in the tumor microenvironment. It has been shown that the properties of the non-malignant tumor compartment possess prognostic value. The effects that these three stromal cell types have on cancer progression have been studied, but their exact mechanisms remain still largely
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34

Al-Khaldi, Abdulaziz A. "Therapeutic angiogenesis using autologous bone marrow stromal cells." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32749.

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Objectives. To study marrow stromal cells (MSCs) induced angiogenesis. To examine the possible mechanisms involved in the process. To evaluate neovascularization following implantation of MSCs in ischemic hind limb model.<br>Methods and result. Using murine Matrigel angiogenesis model, we compared MSCs related angiogenesis to that produced by vascular endothelial growth factor (VEGF) and basic fibroblast growth factor. We found that MSCs result in an efficient and organized angiogenesis, arteriogenesis and vasculogenesis. MSC-related angiogenesis is VEGF dependent. MSCs in vivo produce VEGF th
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35

Sory, David Roger Raymond. "Dynamic loading of periosteum-derived mesenchymal stromal cells." Thesis, Imperial College London, 2017. http://hdl.handle.net/10044/1/59138.

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Explosive-generated waves exhibit high-energy loading profiles featured with mechanical characteristics applied over a wide range of strain rates. Recent decades have seen unprecedented occurrence of high-energy trauma associated with blast wave exposure. One such blast-specific pathology is blast-induced heterotopic ossification (bHO), which refers to ectopic bone formation due to inappropriate mesenchymal stromal cell (MSC) osteogenesis in non-skeletal tissues. Significant effort has been made into deciphering the molecular mechanisms that allow the onset of bHO, however little research has
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Ward, Lewis Stuart Corey. "Interactions of mesenchymal stromal cells with their microenvironment." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8278/.

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Mesenchymal stromal cells (MSC) suppress the inflammatory infiltrate through crosstalk with neighbouring endothelium. However, this response is lost at chronic inflammatory sites where stromal cells instead support leukocyte recruitment and upregulate expression of podoplanin. The mechanism and function by which this inflammatory phenotype is established is unknown. We hypothesise that MSC modulation of endothelium is also altered by exposure to inflammatory cytokines, and that expression of podoplanin confers an invasive phenotype, enabling the interaction of these perivascular MSC with circu
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Davies, Julie Theresa. "Activation of adhesion of bone marrow stromal cells." Thesis, St George's, University of London, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.656858.

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Osteoblasts, the bone-forming cells, derive from multipotential bone marrow stromal precursors called colony-forming units-fibroblastic (CFU-F). CFU-F rapidly adhere to plastic upon culture ex vivo, adhesion of such stromal precursors to bone in vivo is likely to be an early event in the anabolic response to bone stimulatory factors. It has been suggested that osteoclasts are involved in the activation of bone formation during bone remodelling. In order to test this, osteoclast conditioned medium was prepared from osteoclasts cultured on either plastic or bone. It was then used as culture medi
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CROCE, STEFANIA. "Mesenchymal stromal cells on bioscaffold for liver bioengineering." Doctoral thesis, Università degli studi di Pavia, 2020. http://hdl.handle.net/11571/1329186.

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Tissue bioengineering is the creation of functional tissues or whole organs by manufacturing body parts ex vivo, seeding cells on a supporting scaffold. The final goal of organ bioengineering is the use of the bioengineered organs as ‘replacement parts’ for the human body. The need for bioengineered livers is significant: currently, the only effective treatment for end-stage liver failure is orthotopic liver transplantation. However, the shortage of organ donors results every year in the death of many patients in the waiting list. Moreover, the advantage of this technology is the use of autolo
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Clutter, Suzanne Davis. "Chemotherapy disrupts bone marrow stromal cell function." Morgantown, W. Va. : [West Virginia University Libraries], 2006. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=4528.

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Thesis (Ph. D.)--West Virginia University, 2006.<br>Title from document title page. Document formatted into pages; contains x, 180 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.
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Nyambo, Rachel Netsai. "Signalling interactions between human bone marrow stromal cells and prostate cancer cells." Thesis, University of Sheffield, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420799.

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Jones, Simon. "Characterisation of the anti-proliferative properties of stromal cells." Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486913.

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It has been widely demonstrated that mesenchymal stem cells (MSC) are capable of exerting powerful in vitro and in vivo suppressive effects on virtually all cells of the immune system. However, there is little information as to whether more mature mesenchymal stromal cells (SC) share the same property. To address this, I have characterised mature mesenchymal cells from a variety of tissues including articular cartilage, synovium, skin and lung and cOlTlpared them to MSC. The differentiation potential and surface phenotype of SC was evaluated, whilst the ability of SC from different human tissu
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Chu, Jennifer. "Enhanced engraftment of genetically modified bone marrow stromal cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ58851.pdf.

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Alsabti, Hilal. "Delivery of marrow stromal cells for angiogenesis : therapeutic implications." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=97891.

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There is tremendous enthusiasm for the utilization of angiogenesis as a therapeutic modality for atherosclerotic arterial disease. Augmentation of physiological neo-vascularization in cardiovascular disease can be achieved through different pathways. Marrow stromal cells may serve as an ideal cellular vehicle for the in vivo delivery of therapeutic proteins or production of these proteins by the cells themselves. The use of autologous marrow stromal cells is highly desirable since marrow stromal cells are abundant and available in all human of all ages and they are easy to harvest and reimplan
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Konan, S. "Augmenting osseointegration of implants using bone marrow stromal cells." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1382600/.

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Introduction: The greatest challenge facing the success of orthopaedic implants is improving their fixation to bone to enhance their longevity. Bone marrow stromal cells (BMSC), are a population of plastic-adherent cells derived from the bone marrow. The main hypothesis of this thesis is that viable BMSC can be applied to implants using a fibrin glue-spray system; and increase bone formation adjacent to the implants and improve bone-implant contact. Methods: The experiments were undertaken in a large animal model. Four scenarios were tested 1) The ability of BMSC to improve implant fixation us
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Dhadda, Paramjeet Kaur. "Using mesenchymal stromal cells to improve islet transplantation outcome." Thesis, King's College London (University of London), 2014. http://kclpure.kcl.ac.uk/portal/en/theses/using-mesenchymal-stromal-cells-to-improve-islet-transplantation-outcome(aef61279-a461-4023-8a23-7caceae29a1a).html.

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Pancreatic islet transplantation is an attractive treatment option for a subset of patients with Type 1 diabetes. However islet transplantation efficacy remains hampered by a number of factors, including the impaired quality of isolated islets available for transplantation and the loss of long-term islet function post transplantation. Harnessing the properties of multipotent mesenchymal stromal cells (MSCs), which can be derived from numerous clinically relevant post-natal tissues including adipose and pancreas, is currently under investigation for improving the survival of islet cells during
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Correia, Dos Reis Mónica Sofia. "Mesenchymal stromal cells : mode of action and clinical translation." Thesis, University of Newcastle upon Tyne, 2016. http://hdl.handle.net/10443/3456.

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Mesenchymal Stromal Cells (MSCs) are an extensively used cell type in clinical trials for the treatment of various diseases. In order to obtain clinically relevant numbers, MSCs need to be expanded in vitro, usually relying on the use of foetal calf serum (FCS), which is now not recommended by the regulatory authorities. In addition, the precise mechanism of action of MSCs remains unclear. The initial rationale for the therapeutic potential of MSCs was based on their engraftment and differentiation ability. It gets increasingly clear that MSCs exert their effects in a paracrine manner, by the
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Atoui, Rony R. "Marrow stromal cells as "universal donor cells" for myocardial regenerative therapy." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101837.

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Background. Recently rodent and porcine bone marrow stromal cells (MSCs) have been reported to be uniquely immune tolerant. In order to confirm these findings in human cells, we tested the hypothesis that human MSCs are also immune tolerant, such that they can be useful as "universal donor cells" for myocardial regenerative therapy.<br>Methods. Immunocompetent female rats underwent left coronary ligations (n=90). They were randomized into 3 groups. In Group I, lac-Z labeled male human MSCs were implanted into the peri-infarcted area. In Group II and III isogenic rat MSCs or culture medium were
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Lemoine, François Michel. "Studies of the interactions between stromal cells and B lymphoid progenitors." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/28856.

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The overall goal of the work, described in this thesis was to investigate the molecular mechanisms that regulate normal pre-B cell proliferation and how these may be altered in transformed pre-B cells. Monoclonal antibodies and molecular biological techniques have allowed a number of stages of pre-B cell differentiation to be defined but little is known about mechanisms controlling their proliferation. Studies of pre-B cell production in animal models and in long-term cultures that support pre-B cell proliferation have suggested that stromal cells play a key role in this regard. As a first st
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Mort, Richard Lester. "Stem cell function in the mouse corneal epithelium." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/8187.

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Limbal stem cells maintain the corneal epithelium through a process of clonal growth and ordered migration. In X-inactivation mosaic female mice, that express LacZ from one of their X-chromosomes, random clumps of LacZ-positive cells are seen in the cornea at 3-6 weeks of life. This pattern resolves between 6-10 weeks forming radial stripes thought to represent chords of clonally related, inwardly migrating cells. By measuring the number and width of stripes and correcting for the effects of different proportions of LacZ-positive cells, an estimate of the number of coherent stem cell clones ma
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50

Rovere, Maria. "Reconstruction cornéenne : traitement des déficiences en cellules souches limbiques totales et bilatérales associées ou non à une atteinte du stroma." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1263.

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Certaines brûlures oculaires graves ou d'autres pathologies oculaires rares peuvent être associées à une perte totale de cellules souches épithéliales de la cornée (DCSL), ce qui conduit à une opacification de la cornée par invasion de la conjonctive. Lorsque la DCSL est totale et bilatérale, le limbe controlatéral n'est pas disponible pour la greffe de limbe autologue ou la culture de cellules souches autologues limbiques et la transplantation allogénique de la cornée est impossible car toujours rejetée en raison de la néovascularisation. Une thérapie innovante testée avec succès au sein de n
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