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Journal articles on the topic 'Corneal Fluorescein Staining'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Wang, Shaopan, Jiezhou He, Xin He, et al. "AES-CSFS: an automatic evaluation system for corneal sodium fluorescein staining based on deep learning." Therapeutic Advances in Chronic Disease 14 (January 2023): 204062232211482. http://dx.doi.org/10.1177/20406223221148266.

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Background: Corneal fluorescein sodium staining is a valuable diagnostic method for various ocular surface diseases. However, the examination results are highly dependent on the subjective experience of ophthalmologists. Objectives: To develop an artificial intelligence system based on deep learning to provide an accurate quantitative assessment of sodium fluorescein staining score and the size of cornea epithelial patchy defect. Design: A prospective study. Methods: We proposed an artificial intelligence system for automatically evaluating corneal staining scores and accurately measuring patc

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An, Seungwon, Khandaker Anwar, Mohammadjavad Ashraf, Kyu-Yeon Han, and Ali R. Djalilian. "Chlorine-Induced Toxicity on Murine Cornea: Exploring the Potential Therapeutic Role of Antioxidants." Cells 13, no. 5 (2024): 458. http://dx.doi.org/10.3390/cells13050458.

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Chlorine (Cl2) exposure poses a significant risk to ocular health, with the cornea being particularly susceptible to its corrosive effects. Antioxidants, known for their ability to neutralize reactive oxygen species (ROS) and alleviate oxidative stress, were explored as potential therapeutic agents to counteract chlorine-induced damage. In vitro experiments using human corneal epithelial cells showed decreased cell viability by chlorine-induced ROS production, which was reversed by antioxidant incubation. The mitochondrial membrane potential decreased due to both low and high doses of Cl2 expo

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Schultz, C. L., A. G. Buret, M. E. Olson, H. Ceri, R. R. Read, and D. W. Morck. "Lipopolysaccharide Entry in the Damaged Cornea and Specific Uptake by Polymorphonuclear Neutrophils." Infection and Immunity 68, no. 3 (2000): 1731–34. http://dx.doi.org/10.1128/iai.68.3.1731-1734.2000.

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ABSTRACT Bacterial lipopolysaccharide (LPS) is an important agent of induction of ocular pathology following corneal injury or wearing of contaminated contact lenses. The mechanism of LPS uptake through the corneal epithelium is unclear, and the role played by inflammatory cells in this phenomenon has not been previously assessed. Fluorescein isothiocyanate-labeled LPS from Escherichia coli was deposited onto the abraded corneas of New Zealand White rabbits. Epifluorescence microscopy of living excised corneas revealed diffuse LPS staining in the epithelial and stromal layers only in the vicin

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Saks, Mark, and Bruce Nisbet. "Corneal Abrasion With Fluorescein Staining." Visual Journal of Emergency Medicine 2 (January 2016): 29–30. http://dx.doi.org/10.1016/j.visj.2015.07.008.

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Sindt, Christine W., D. Brice Critser, Trudy K. Grout, and Jami R. Kern. "Effects of Fluorescein Staining on Laser In Vivo Confocal Microscopy Images of the Cornea." Journal of Ophthalmology 2012 (2012): 1–4. http://dx.doi.org/10.1155/2012/541974.

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This study was designed to identify whether topical fluorescein, a common ophthalmic tool, affects laser in vivo confocal microscopy of the cornea, a tool with growing applications. Twenty-five eye care specialists were asked to identify presence or absence of fluorescein in 99 confocal micrographs of healthy corneas. Responses were statistically similar to guessing for the epithelium (48% ± 14% of respondents correct per image) and the subbasal nerve plexus (49% ± 11% correct), but results were less clear for the stroma. Dendritic immune cells were quantified in bilateral images from subjects

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Feng, Jun, Zi-Kai Ren, Kai-Ni Wang, et al. "An Automated Grading System Based on Topological Features for the Evaluation of Corneal Fluorescein Staining in Dry Eye Disease." Diagnostics 13, no. 23 (2023): 3533. http://dx.doi.org/10.3390/diagnostics13233533.

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Background: Corneal fluorescein staining is a key biomarker in evaluating dry eye disease. However, subjective scales of corneal fluorescein staining are lacking in consistency and increase the difficulties of an accurate diagnosis for clinicians. This study aimed to propose an automatic machine learning-based method for corneal fluorescein staining evaluation by utilizing prior information about the spatial connection and distribution of the staining region. Methods: We proposed an end-to-end automatic machine learning-based classification model that consists of staining region identification

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Guo, Owen, Brent Ju, McKinley H. Shawver, et al. "Recombinant Human MG53 Protein Protects Against Alkaline-Induced Corneal Injuries in Mice." Military Medicine 186, Supplement_1 (2021): 486–90. http://dx.doi.org/10.1093/milmed/usaa357.

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ABSTRACT Introduction The current study was designed to test the potential role of recombinant human MG53 (rhMG53) protein on protecting against alkaline-induced corneal injury in mice. Materials and Methods A round filter paper with 2-mm diameter was soaked in 1 mol/L of NaOH solution. The mouse alkaline injury was generated by placing the filter paper directly on the cornea for 30 seconds and washed with 30-mL saline; 10 µL of rhMG53 solution (20 µg/mL) or saline control was topically administrated on the mouse corneas (twice per day for 10 days). Re-epithelialization was measured by fluores

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8

Yi, Qiong, and Wen-jin Zou. "The Wound Healing Effect of Doxycycline after Corneal Alkali Burn in Rats." Journal of Ophthalmology 2019 (October 10, 2019): 1–10. http://dx.doi.org/10.1155/2019/5168652.

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Purpose. To evaluate the wound healing effect of doxycycline and its underlying mechanisms in a rat model of corneal alkali burn. Methods. Male SD rats were administered 1.0 N NaOH in the right cornea for 25 seconds and randomly divided into the doxycycline group and the control group, with 84 rats in each group. 1.0 g·L−1 doxycycline eye drops (doxycycline group) or vehicle (control group) was topically instilled onto the rat cornea after chemical injury. Three days, 7 days, and 14 days after alkali burn, microscopy was used to observe corneal wound healing by fluorescein staining and the deg

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9

McDaniel, Jennifer S., Barbara Wirostko, Cassie Sprague, Anthony J. Johnson, and Gina L. Griffith. "The Effects of Phosphate Buffered Saline on Corneal Chemical Alkali Burns." Journal of Ocular Diseases and Therapeutics 5 (February 27, 2017): 28–34. http://dx.doi.org/10.12974/2309-6136.2017.05.05.

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Background: Treatments administered after a corneal burn injury can have long term implications on wound healing. Initial treatments can include the administration of lubricants, anti inflammatories, and antibiotic eye drops, many of which contain phosphate buffered saline (PBS) as a vehicle. As a result, the purpose of this study was to observe the effects of the commonly used PBS ophthalmic drop vehicle on corneal alkali burns over 30 days when treated 4X daily for the first 14 days. Materials and Methods: Corneal alkali burns 5.5 mm in diameter were created on 10 anesthetized, male New Zeal

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Brooks, D. E., S. E. Andrew, H. M. Denis, et al. "Rose bengal positive epithelial microerosions as a manifestation of equine keratomycosis." Veterinary Ophthalmology 3, no. 2-3 (2000): 83–86. http://dx.doi.org/10.1046/j.1463-5224.2000.3230083.x.

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Abstract Purpose To describe the clinical appearance of corneal epithelial cell microerosions associated with keratomycosis in the horse. Methods Retrospective clinical study. Results Multifocal, punctate, superficial corneal opacities with positive rose bengal retention were noted in six horses with presumed ‘viral keratitis’. Faint fluorescein staining was also present in three cases. Equine herpesvirus tissue culture inoculation was negative for a cytopathic effect in three cases. Aspergillus (n= 3), Curvularia (n= 1), and an unidentified fungus (n= 1) were cultured in five horses, and hyph

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Chan, Sze-Min, Hui-Wen Chang, Pei-Shiue Tsai, et al. "CLINICAL AND HISTOPATHOLOGICAL FEATURES OF SCOPOLAMINE HYDROBROMIDE INDUCED DRY EYE SYNDROME IN SPRAGUE-DAWLEY RATS." Taiwan Veterinary Journal 46, no. 04 (2020): 143–50. http://dx.doi.org/10.1142/s1682648520500134.

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Dry eye syndrome (DES), is one of the most common and irritating ocular diseases in humans and animals due to deficits in quantities or/and quality of tear film. In this study, a rat model of experimental DES has been developed using the cholinergic inhibitor, scopolamine hydrobromide (SCOP), at the dose of 25[Formula: see text]mg/rat/day via subcutaneous injection, for a consecutive 21 days without low humidity environment. Clinical ophthalmic evaluations were performed by tear volume assessment using endodontic paper point, slit-lamp biomicroscope, and fluorescein staining at day 0, 7, 14, a

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Gushchina, M. B., A. V. Tereshchenko, D. S. Afanasyeva, and A. G. Nadtochiy. "Prediction of corneal complications in patients with paralytic lagophthalmos." Modern technologies in ophtalmology, no. 6 (November 9, 2022): 64–70. http://dx.doi.org/10.25276/2312-4911-2022-6-64-70.

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Introduction. Paralytic lagophthalmos can be accompanied by the development of severe complications up to the loss of visual functions and even the eye as an organ. Purpose. To identify the causes of severe corneal complications in patients with paralytic lagophthalmos. Material and methods. We conducted a retrospective analysis of 114 clinical cases of paralytic lagophthalmos. All the patients received tear replacement therapy. For diagnostics, all of them underwent ophthalmological examination, corneal estesiometry, eyeball mobility assessment, Schirmer test 1, photography of the corneal sur

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Che, Dan-Yang, Ji-Bo Zhou, and Dong-Qing Zhu. "Silicone oil as a corneal lubricant to reduce corneal edema and improve visualization during vitrectomy." International Journal of Ophthalmology 17, no. 1 (2024): 92–96. http://dx.doi.org/10.18240/ijo.2024.01.12.

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AIM: To evaluate the efficacy and safety of silicone oil (SO) as a corneal lubricant to improve visualization during vitrectomy. METHODS: Patients who underwent vitreoretinal surgery were divided into two groups. Group 1 was operated on with initial SO (Oxane 5700) as a corneal lubricant. Group 2 was operated on with initial lactated ringer's solution (LRS) and then replaced with SO as required. Fundus clarity was scored during the surgery. Fluorescein staining was performed to determine the damage to corneal epithelium. RESULTS: Totally 114 eyes of 114 patients were included. Single SO use ma

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Minina, A. O., A. V. Bokarev, E. Ya Pilipets, and E. V. Prudnikova. "Retention periods of diagnostic dyes on a cut corneal wound." International Journal of Veterinary Medicine, no. 4 (December 18, 2023): 473–79. http://dx.doi.org/10.52419/issn2072-2419.2023.4.473.

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Comparative studies of four main ophthalmic dyes were carried out on their ability, after a single short-term exposure, to stain a corneal incised wound.12 year–old Wistar rats weighing 180-220 grams were selected for the study. 4 experimental groups of 3 rats each were formed from them. Corneal incision wounds were inflicted on all animals. A 10.0% lidocaine solution was used to anesthetize the cornea. Before applying the cut wound, the animals were injected into anesthesia with the drug "Sevoflurane". The depth of the wound was monitored visually using a microscope at a magnification of 4-6

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Fischak, Corinna, Robert Klaus, René M. Werkmeister, et al. "Effect of Topically Administered Chitosan-N-acetylcysteine on Corneal Wound Healing in a Rabbit Model." Journal of Ophthalmology 2017 (2017): 1–6. http://dx.doi.org/10.1155/2017/5192924.

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Purpose. The present study was performed to investigate the effect of topically administered chitosan-N-acetylcysteine (C-NAC) on corneal wound healing in a rabbit model.Methods. A total of 20 New Zealand White rabbits were included in the randomized, masked, placebo-controlled experiment. A monocular epithelial debridement was induced by manual scraping under general anesthesia. Animals were randomized to receive either C-NAC two times daily or placebo. Monitoring of corneal wound healing was performed with ultra-high-resolution optical coherence tomography (OCT) and epithelial fluorescein st

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JOSEPHSON, JOSHUA E., and BARBARA E. CAFFERY. "Corneal Staining Characteristics after Sequential Instillations of Fluorescein." Optometry and Vision Science 69, no. 7 (1992): 570–73. http://dx.doi.org/10.1097/00006324-199207000-00012.

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17

Edirisinghe, Shan Lakmal, Chamilani Nikapitiya, S. H. S. Dananjaya, et al. "Effect of Polydeoxyribonucleotide (PDRN) Treatment on Corneal Wound Healing in Zebrafish (Danio rerio)." International Journal of Molecular Sciences 23, no. 21 (2022): 13525. http://dx.doi.org/10.3390/ijms232113525.

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This study aimed to develop a corneal epithelial injury model in zebrafish (Danio rerio) and investigate the effectiveness of polydeoxyribonucleotide (PDRN) treatment on in vivo corneal epithelial regeneration and wound healing. Chemical injury to zebrafish cornea was produced by placing a small cotton swab containing 3% acetic acid solution. PDRN treatment was performed by immersing corneal-injured zebrafish in water containing PDRN (2 mg/mL) for 10 min at 0, 24, 48, and 72 h post-injury (hpi). The level of corneal healing was evaluated by fluorescein staining, histological examination, trans

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18

Rajpoot, Mukesh, Divya Singh, Kankambari Pandey, and Rahul Bhargava. "Safety and efficacy of cyclosporine (0.05% versus 0.09%) in dry eye disease. Is it the strength of cyclosporin that really matters?" Nepalese Journal of Ophthalmology 14, no. 2 (2022): 64–77. http://dx.doi.org/10.3126/nepjoph.v14i2.38928.

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Introduction: This is a multicenter, randomized, interventional, double masked study aimed to compare safety and efficacy of cyclosporine (0.05% versus 0.09%) in dry eye disease. Materials and methods: Random allocation of patients (n=450) was done in two groups by parallel assignment (1:1). Group1(n=225) received CAs 0.05% drops twice daily, and group 2 (n=225) received CAs 0.09% drops twice daily for 3 months. Primary outcomes were changes from baseline in Lissamine green staining score, Nelson grade on conjunctival impression cytology and tear film osmolarity. Secondary outcomes were change

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Lutsenko, N. S., O. A. Isakova, O. A. Rudycheva, T. S. Kyrilova, and T. S. Mihalchik. "SOME QUESTIONS ABOUT THE STATE OF THE EYE SURFACE IN PATIENTS BEFORE CATARACT SURGERY." Modern medical technologies 46, no. 3 (2020): 21. http://dx.doi.org/10.34287/mmt.3(46).2020.4.

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Introduction. Ocular surface status is a main risk factor for the development of postoperative complications and lead to the decrease of life quality. Purpose of the study.The condition of the surface of the eye in patients before cataract surgery was study. Material and methods. 320 patients preoperative the cataract surgery were investigated, among them 172 patients were female, 148 – were male. Patients with any previous ocular surgery or concomitant ocular diseases were excluded. The structure of common non-ocular comorbidities, subjective signs of ocular surface damage (redness, foreign b

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Chan, Sze-Min, Chris Tsai, Tai-Ping Lee, Zih-Rou Huang, Wei-Hsiang Huang, and Chung-Tien Lin. "Therapeutic Potential of Umbilical Cord MSC-Derived Exosomes in a Severe Dry Eye Rat Model: Enhancing Corneal Protection and Modulating Inflammation." Biomedicines 13, no. 5 (2025): 1174. https://doi.org/10.3390/biomedicines13051174.

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Background/Objectives: Dry eye disease (DED) is a multifactorial inflammatory disease that disrupts the ocular surface, causing tear film instability, epithelial damage, and chronic inflammation. Mesenchymal stem cell-derived exosomes (MSC-exos) are promising therapeutics with immunomodulatory and regenerative properties. This study investigates the therapeutic effects of umbilical cord MSC-derived exosomes (UCMSC-exos) in a severe dry eye model, induced by a surgical resection of the infra-orbital (ILG) and extra-orbital lacrimal gland (ELG) in rats. Methods: Clinical evaluations, including t

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EL-Shazly, Amany, Amal EL-Gohary, Laila EL-Shazly, and Ghada EL-Hossary. "Comparison between two cyclooxygenase inhibitors in an experimental dry eye model in albino rabbits." Acta Pharmaceutica 58, no. 2 (2008): 163–73. http://dx.doi.org/10.2478/v10007-008-0009-0.

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Comparison between two cyclooxygenase inhibitors in an experimental dry eye model in albino rabbitsThe purpose of this study was to compare the topical anti-inflammatory effects of the nonselective cyclooxygenase (COX) inhibitor, ketorolac, with the selective COX-2 inhibitor, nimesulide, in an animal model of dry eye in albino rabbits. All animals were examined by the Schirmer test, tear break-up time (TBUT) and fluorescein corneal staining test. Dry eye model showed significant reduction in tear volume, TBUT, corneal staining and histopathological signs of dryness and inflammation. On treatin

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Hao, Mi, Jie Wu, Yu Cheng, and Jing Wang. "Clinical observation of recombinant human nerve growth factor in the treatment of neurotrophic keratitis." International Journal of Ophthalmology 16, no. 1 (2023): 60–66. http://dx.doi.org/10.18240/ijo.2023.01.09.

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AIM: To characterize changes of corneal nerve morphology and tear indices in patients with neurotrophic keratitis (NK) treated with recombinant human nerve growth factor (rhNGF). METHODS: In a prospective observational study, six patients (nine eyes) were locally treated with rhNGF. Visual acuity, corneal fluorescein staining score, the heights of the tear river, lipid layer thickness (LLT), tear ferning (TF) test, conjunctival impression cytology (CIC) examination, the densities of cornea subbasal nerve fibers were determined before and after treatment. RESULTS: Compared with baseline, there

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Chen, Minting, Abdirahman Abdinasir Gureeye, Yacouba Cissé, and Lang Bai. "The Therapeutic Effects and Possible Mechanism of Pranoprofen in Mouse Model of Corneal Alkali Burns." Journal of Ophthalmology 2020 (April 7, 2020): 1–9. http://dx.doi.org/10.1155/2020/7485912.

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Objective. To investigate therapeutic effects and possible mechanism of pranoprofen in a mouse model of corneal alkali burns and provide new evidence for the clinical treatment of corneal alkali burns. Methods. A unilateral alkali burn was created in the central cornea by placing a piece of 2 mm diameter filter paper soaked in 1N NaOH on the right eye for 30 seconds. After the model was performed, C57BL/6J mice received topical treatment with saline eye drops or pranoprofen eye drops and were, respectively, categorized as saline group and pranoprofen group, whereas the remaining normal mice th

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Amparo, Francisco, Haobing Wang, Jia Yin, Anna Marmalidou, and Reza Dana. "Evaluating Corneal Fluorescein Staining Using a Novel Automated Method." Investigative Opthalmology & Visual Science 58, no. 6 (2017): BIO168. http://dx.doi.org/10.1167/iovs.17-21831.

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Bandamwar, Kalika L., Eric B. Papas, and Qian Garrett. "Fluorescein staining and physiological state of corneal epithelial cells." Contact Lens and Anterior Eye 37, no. 3 (2014): 213–23. http://dx.doi.org/10.1016/j.clae.2013.11.003.

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Ortiz, J. P. D., C. B. S. Lisbão, F. L. C. Brito, B. Martins, and J. L. Laus. "Superficial keratectomy and 360º conjunctival flap for bullous keratopathy in a dog: a case report." Arquivo Brasileiro de Medicina Veterinária e Zootecnia 63, no. 3 (2011): 773–77. http://dx.doi.org/10.1590/s0102-09352011000300036.

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A case of a two-year-old male Pinscher with a history of discomfort in the right eye was reported. The left eye had been enucleated by the referring veterinarian due to the same symptom with unsuccessful clinical treatment. The Schirmer tear test value was elevated and a decreased intraocular pressure was observed by applanation tonometry. Biomicroscopy revealed profuse corneal edema and keratoconus and fluorescein staining was negative. Gonioscopy and ophthalmoscopy did not provide any relevant data due to the corneal alterations. Bullous keratopathy was diagnosed. Surgery was performed in tw

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Li-Chien, Yang, Lin David Pei-Cheng, Chang Han-Hsin, and Tung Kwong-Chung. "Caffeic Acid Phenethyl Ester Reduces Hypoxia-Induced Reactive Oxygen Species and Mitigatates Inflammation in Corneal Endothelial BCE C/D-1b Cells." Current Topics in Nutraceutical Research 17, no. 4 (2019): 401–5. http://dx.doi.org/10.37290/ctnr2641-452x.17:401-405.

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Oxygen supply is crucial to the health of avascular human cornea where low-oxygen-transmissible soft contact lenses often cause keratitis upon excessive wear time. Caffeic acid phenethyl ester, an active component of propolis, has anti-oxidative and anti-inflammatory properties. This study investigated the in vitro effects of caffeic acid phenethyl ester on corneal inflammation and its underlying action. We measured NF-κB activity and Dichloro-dihydro-fluorescein diacetate staining to demonstrate that caffeic acid phenethyl ester ameliorates hypoxia-induced inflammation of corneal endothelial

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Cui, David, Priya Mathews, Gavin Li, Shanna VanCourt, and Esen Akpek. "Outcomes of Sjögren’s versus non-Sjögren’s related dry eye in a longitudinal, tertiary clinic-based sample." PLOS ONE 16, no. 12 (2021): e0261241. http://dx.doi.org/10.1371/journal.pone.0261241.

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Purpose To assess the long-term treatment outcomes of dry eye in patients with and without underlying primary Sjögren’s syndrome (SS). Design Retrospective longitudinal cohort. Methods SS and non-SS dry eye patients with clinic visits for a minimum of 5 consecutive years at a tertiary, dedicated dry eye clinic were included. Electronic health records were reviewed to collect data regarding demographics, objective dry eye parameters, treatments utilized at baseline and final visit, and corneal complications observed during follow-up. Results Two hundred and two patients (101 SS and 101 randomly

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Liao, Yukun, Huiting Jiang, Yangrui Du, Xiaojing Xiong, Yu Zhang, and Zhiyu Du. "Using Convolutional Neural Network as a Statistical Algorithm to Explore the Therapeutic Effect of Insulin Liposomes on Corneal Inflammation." Computational Intelligence and Neuroscience 2022 (July 31, 2022): 1–9. http://dx.doi.org/10.1155/2022/1169438.

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Aiming at the disadvantages of easy recurrence of keratitis, difficult eradication by surgery, and easy bacterial resistance, insulin-loaded liposomes were prepared, and convolutional neural network was used as a statistical algorithm to build SD rat corneal inflammation model and study insulin-loaded liposomes, alleviating effect on corneal inflammatory structure in SD rats. The INS/PFOB@LIP was developed by means of thin-film dispersive phacoemulsification, its structure was monitored using a transmission electron microscope, particle size and appearance potential were monitored using a Malv

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Hao, Ran, and Xue-Min Li. "Leptin’s concentration in tears and dry eye: a clinical observational study." International Journal of Ophthalmology 14, no. 1 (2021): 83–88. http://dx.doi.org/10.18240/ijo.2021.01.12.

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AIM: To investigate the concentration of leptin in tears and its correlation with dry eye symptoms and signs. METHODS: The study enrolled individuals (n=39) responding to an advertising or dry eye patients (n=58) from the Ophthalmology Department. Tear samples were collected for leptin concentration measuring. Ocular Surface Disease Index (OSDI), tear meniscus height (TMH), tear break up time (TBUT), cornea fluorescein staining, Schirmer test (ST) and impression cytology (IC) were assessed. Leptin concentration in tears of dry eye patients and healthy controls, and its correlation with clinica

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Bonci, Po, Pa Bonci, and A. Lia. "Suspension Made with Amniotic Membrane: Clinical Trial." European Journal of Ophthalmology 15, no. 4 (2005): 441–45. http://dx.doi.org/10.1177/112067210501500403.

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Purpose To investigate if a suspension made with amniotic membrane could have a beneficial effect on ocular surface diseases. Methods In the Imola branch of the Eye Bank of Emilia Romagna, the authors prepared a suspension containing homogenized amniotic membrane previously conserved at −80 degrees Celsius. Subsequently, the authors gave this preparation to 21 patients: 8 had undergone lamellar keratoplasty, 4 had undergone penetrating keratoplasty, 2 had undergone photorefractive keratectomy with a delay of epithelialization, 3 had neurotrophic corneal ulcers, 2 had corneal burning, 1 had tor

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Marchegiani, A., M. Bazzano, MP Cassarani, et al. "Efficacy of riboflavin/UV-A corneal phototherapy as stand-alone treatment for ulcerative keratitis in horses." Veterinární Medicína 66, No. 8 (2021): 321–29. http://dx.doi.org/10.17221/60/2020-vetmed.

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The purpose of this study was to assess the efficacy of riboflavin/UV-A corneal phototherapy in comparison with topical antimicrobials for the treatment of corneal ulcers in horses. Nineteen horses with a diagnosis of corneal ulceration were randomised to receive either corneal phototherapy (11 horses) or topical antimicrobial therapy (8 horses). The corneal phototherapy consisted in the application of a riboflavin-enriched ophthalmic solution onto the cornea for 20 min followed by cornea UV-A irradiation at 30 mW/cm<sup>2</sup> for 3 min using a point-of-care UV-A device. A comple

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Kojima, Masami, Yukihisa Suzuki, Kensuke Sasaki, et al. "Ocular Effects of Exposure to 40, 75, and 95 GHz Millimeter Waves." Journal of Infrared, Millimeter, and Terahertz Waves 39, no. 9 (2018): 912–25. http://dx.doi.org/10.1007/s10762-018-0497-z.

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Abstract The objective of this study was to develop a model of ocular damage induced by 40, 75, and 95 GHz continuous millimeter waves (MMW), thereby allowing assessment of the clinical course of ocular damage resulting from exposure to thermal damage-inducing MMW. This study also examined the dependence of ocular damage on incident power density. Pigmented rabbit eyes were exposed to 40, 75, and 95 GHz MMW from a spot-focus-type lens antenna. Slight ocular damage was observed 10 min after MMW exposure, including reduced cornea thickness and reduced transparency. Diffuse fluorescein staining a

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Komai, Seitaro, Norihiko Yokoi, Hiroaki Kato, et al. "Clinical Implication of Patchy Pattern Corneal Staining in Dry Eye Disease." Diagnostics 11, no. 2 (2021): 232. http://dx.doi.org/10.3390/diagnostics11020232.

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Corneal fluorescein staining in a form that is commonly called a “patchy pattern (PP)” is sometimes seen with or without superficial punctate keratopathy (SPK) in dry-eye diseases (DEDs). Here, we investigated the differences in the clinical features of DED patients with and without PP corneal staining (PPCS). This study involved 35 DEDs with PPCS (PPCS group) and 30 DEDs with SPK and without PPCS (non-PPCS group). The tear meniscus radius (TMR, mm), spread grade (SG) of the tear-film lipid layer (i.e., SG 1–5, 1 being best), noninvasive breakup time (NIBUT, seconds), fluorescein breakup time

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CAFFERY, BARBARA E., and JOSHUA E. JOSEPHSON. "Corneal Staining after Sequential Instillations of Fluorescein Over 30 Days." Optometry and Vision Science 68, no. 6 (1991): 467–69. http://dx.doi.org/10.1097/00006324-199106000-00011.

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Selek, H., N. Ünlü, M. Orhan, and M. Irkeç. "Evaluation of Retinoic Acid Ophthalmic Emulsion in Dry Eye." European Journal of Ophthalmology 10, no. 2 (2000): 121–27. http://dx.doi.org/10.1177/112067210001000205.

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Purpose An oil in water emulsion of 0.01% all-trans-retinoic acid (tretinoin) was prepared and clinically evaluated in dry eye patients. Methods The ophthalmic emulsion consisted of 10% of arachis oil and 90% of the hydro-gel of Carbopol 940. To evaluate retinoic acid emulsion clinically, a placebo-controlled, open-labeled, randomized study was performed with 22 dry-eye patients. Symptoms were recorded before and after the treatments. The Schirmer 112067210001000205l test, measurement of tear film break-up time (BUT), rose Bengal and fluorescein staining of cornea and conjunctiva, and mucus fe

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Pigatto, João Antônio Tadeu, Luciane De Albuquerque, Ângela Beatriz de Oliveira Bacchin, Géssica Maria Ribeiro Da Silva, Michelle Becker Petersen, and Gabriela Grandi Reiter. "Diamond Burr for the Treatment of an Indolent Corneal Ulcer in a Foal." Acta Scientiae Veterinariae 45 (June 27, 2017): 4. http://dx.doi.org/10.22456/1679-9216.85679.

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Background: Indolent corneal ulcers have been described as superficial ulcers with an associated rim of loose peripheral epithelium Treatment for indolent ulcers include debridement, grid keratotomy, multiple punctate keratotomy, third eyelid flaps, application of cyanoacrylate tissue adhesives, superficial keratectomy, and a debridement with a diamond burr.Case: A 2-month-old female American Quarter Horse was referred to the Ophthalmology Veterinary Section of the Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil, presenting epiphora and blepharospasm. A local veterinarian

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Tobita, Yutaro, Takeshi Arima, Yuji Nakano, Masaaki Uchiyama, Akira Shimizu, and Hiroshi Takahashi. "Effects of Selective Peroxisome Proliferator Activated Receptor Agonists on Corneal Epithelial Wound Healing." Pharmaceuticals 14, no. 2 (2021): 88. http://dx.doi.org/10.3390/ph14020088.

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The effects of each subtype-selective peroxisome proliferator activated receptor (PPAR) agonist (α, β/δ, γ) on corneal epithelial wound healing were investigated using a rat corneal alkali burn model. After the alkali burn, each PPAR agonist or vehicle ophthalmic solution was instilled topically onto the rat’s cornea. Corneal epithelial healing processes were evaluated by fluorescein staining. Pathological analyses and real-time reverse transcription polymerase chain reactions were performed to evaluate Ki67 (proliferative maker) expression and inflammatory findings. The area of the corneal ep

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Cortese, D., L. Capp, and S. McKinley. "Moisture chamber versus lubrication for the prevention of corneal epithelial breakdown." American Journal of Critical Care 4, no. 6 (1995): 425–28. http://dx.doi.org/10.4037/ajcc1995.4.6.425.

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BACKGROUND: Patients who are comatose or semicomatose are at risk of corneal dryness and ulceration. OBJECTIVE: To compare and evaluate the effectiveness of two treatments used for the prevention of corneal epithelial breakdown in critically ill patients. METHODS: A randomized clinical trial was used. The sample consisted of critically ill patients (age, 15-84 years) with a limited or absent blink reflex in a 14-bed general intensive care unit in a large metropolitan teaching hospital. Ninety-six eligible patients were studied; of these, 36 were excluded and data from the remaining 60 patients

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Marchegiani, A., R. Gialletti, MP Cassarani, et al. "Riboflavin/UV-A corneal phototherapy as stand-alone management of ulcerative keratitis in dogs." Veterinární Medicína 67, No. 4 (2022): 190–98. http://dx.doi.org/10.17221/46/2021-vetmed.

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Corneal ulcers are one of the most common ocular disorders in veterinary ophthalmology and several factors can negatively influence the efficacy of the currently available therapeutic options, leading to a loss of corneal transparency and, thus, vision. Twenty-five dogs with clinical signs of corneal ulcers were randomised to receive either corneal phototherapy (16 dogs; study group) or topical standard medical therapy (9 dogs; control group). The riboflavin/UV-A corneal phototherapy (PACK-CXL) consisted in the application of a riboflavin ophthalmic solution (Visioflavin<sup>®</sup&gt

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Lee, Hyun Soo, Sehyun Han, Jeong-Won Seo, and Ki-Joon Jeon. "Exposure to Traffic-Related Particulate Matter 2.5 Triggers Th2-Dominant Ocular Immune Response in a Murine Model." International Journal of Environmental Research and Public Health 17, no. 8 (2020): 2965. http://dx.doi.org/10.3390/ijerph17082965.

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Ambient particulate matter (PM), a major component of air pollution, aggravates ocular discomfort and inflammation, similarly to dry eye disease (DED) or allergies. However, the mechanism(s) by which PM induces the ocular inflammatory response is unknown. This study investigated the immunological response of traffic-related fine particulate matter (PM2.5) on the ocular surface in a murine model. C57BL/6 mice were exposed by topical application to PM2.5 or vehicle for 14 days to induce experimental environmental ocular disease. Corneal fluorescein staining and the number of ocular inflammatory

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Yoon, Hyeon-Jeong, Enying Jiang, Jingting Liu, et al. "A Selective Melatonin 2 Receptor Agonist, IIK7, Relieves Blue Light-Induced Corneal Damage by Modulating the Process of Autophagy and Apoptosis." International Journal of Molecular Sciences 25, no. 20 (2024): 11243. http://dx.doi.org/10.3390/ijms252011243.

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This study aims to investigate the effect of the selective MT2 receptor agonist, IIK7, on corneal autophagy and apoptosis, aiming to reduce corneal epithelial damage and inflammation from blue light exposure in mice. Eight-week-old C57BL/6 mice were divided into BL-exposed (BL) and BL-exposed with IIK7 treatment (BL + IIK7 group). Mice underwent blue light exposure (410 nm, 100 J) twice daily with assessments at baseline and on days 3, 7, and 14. Corneal samples were analyzed for MT2 receptor expression, autophagy markers (LC3-II and p62), and apoptosis indicators (BAX expression and TUNEL ass

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Kaido, Minako, Yukihiro Matsumoto, Yuta Shigeno, Reiko Ishida, Murat Dogru, and Kazuo Tsubota. "Corneal Fluorescein Staining Correlates with Visual Function in Dry Eye Patients." Investigative Opthalmology & Visual Science 52, no. 13 (2011): 9516. http://dx.doi.org/10.1167/iovs.11-8412.

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Romano, Dario, Valentino De Ruvo, Paolo Fogagnolo, Roberta Farci, and Luca Mario Rossetti. "Inter-Eye Comparison of the Ocular Surface of Glaucoma Patients Receiving Surgical and Medical Treatments." Journal of Clinical Medicine 11, no. 5 (2022): 1238. http://dx.doi.org/10.3390/jcm11051238.

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Background: Ocular surface frequently affects glaucoma patients. In this paper we aimed at evaluating the impact of glaucoma surgery on the ocular surface of patients who received unilateral trabeculectomy. Methods: 26 consecutive patients successfully treated with trabeculectomy on one eye (Trab Eye) and under control with topical treatments on the fellow eye (Med Eye) were included in this observational study. They received IDEEL and OSDI questionnaires, Tear Film Osmolarity (TFO), grading of conjunctival hyperemia, fluorescein tear break-up time (tBUT), grading of corneal staining and Schir

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Norn, Mogens. "Double vital staining of corneal epithelium after corneal transplantation with a rose bengal-fluorescein mixture." Acta Ophthalmologica 66, no. 6 (2009): 699–704. http://dx.doi.org/10.1111/j.1755-3768.1988.tb04064.x.

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Li, Qingjian, Yankun Shen, Shinan Wu, et al. "MLN4924 Promotes Self-Renewal of Limbal Stem Cells and Ocular Surface Restoration." Journal of Personalized Medicine 13, no. 3 (2023): 379. http://dx.doi.org/10.3390/jpm13030379.

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Objective: To study the role of MLN4924 in corneal stem cell maintenance and corneal injury repair. Methods: In cell experiments, the Sprague–Dawley (SD) rat corneal epithelial cells were co-cultured with mitomycin C-inactivated mouse feeder cells in a supplemental hormonal epithelial medium (SHEM) with or without MLN4924. Cells were photographed using an optical microscope. Furthermore, we performed crystal violet, polymerase chain reaction (PCR), and immunofluorescence staining on limbal stem cells (LSCs). In animal experiments, we scraped the corneal epithelium with a central corneal diamet

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Leonardi, Andrea, Daniela Lazzarini, Alvise La Gloria Valerio, Tania Scalora, and Iva Fregona. "Corneal staining patterns in vernal keratoconjunctivitis: the new VKC-CLEK scoring scale." British Journal of Ophthalmology 102, no. 10 (2018): 1448–53. http://dx.doi.org/10.1136/bjophthalmol-2017-311171.

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AimTo propose a new scoring system in the assessment of ocular surface epithelial damage in vernal keratoconjunctivitis (VKC).Methods25 consecutive patients with VKC (50 eyes) were evaluated using the Quality of Life in children with VKC (QUICK) questionnaire and objective clinical measures: fluorescein and lissamine green staining and cornea confocal microscopy (Heidelberg Retina Tomography 3). Oxford, Van Bljsterweld and a new system, the VKC-Collaborative Longitudinal Evaluation of Keratoconus study (CLEK) (VKC-CLEK) scores, were used to evaluate the epithelial damage after staining.Results

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Zhong, Jing, Yuqing Deng, Bishan Tian, et al. "Hyaluronate Acid-Dependent Protection and Enhanced Corneal Wound Healing against Oxidative Damage in Corneal Epithelial Cells." Journal of Ophthalmology 2016 (2016): 1–10. http://dx.doi.org/10.1155/2016/6538051.

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Purpose. To evaluate the effects and mechanism of exogenous hyaluronate (HA) in promoting corneal wound healing.Methods. Human corneal epithelial cells (HCECs) were incubated with different concentrations of HA to evaluate their efficiency in promoting cell migration and their modulation of repair factors. After inducing hyperosmolar conditions, the cell morphologies, cell apoptosis, and expression levels of TNF-αand MMP-9 were detected to assess the protective role of HA. Corneal epithelium-injured rat models were established to test the therapeutic effects of 0.3% HA. Then, the wound healing

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Kessal, Karima, Philippe Daull, Nicolas Cimbolini, et al. "Comparison of Two Experimental Mouse Dry Eye Models through Inflammatory Gene Set Enrichment Analysis Based on a Multiplexed Transcriptomic Approach." International Journal of Molecular Sciences 22, no. 19 (2021): 10770. http://dx.doi.org/10.3390/ijms221910770.

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The goal of this study was to explore the specific signaling pathways related to inflammation in two experimental mouse dry eye (EDE) models. Female C57BL/6 mice housed for 10 days in a controlled desiccative environment were either treated with scopolamine (EDE-1; n = 18) or subjected to extraorbital lacrimal gland excision bilaterally (EDE-2; n = 10). Non-induced mice (n = 20) served as healthy controls. A corneal fluorescein staining (CFS) scoring was used at baseline through to day (D) 10 to evaluate epitheliopathy. At D10, corneas and conjunctivas were collected for multiplexed transcript

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Wong, Natalie Shi Qi, Chang Liu, Molly Tzu-Yu Lin, Isabelle Xin Yu Lee, Louis Tong, and Yu-Chi Liu. "Neuropathic Corneal Pain after Coronavirus Disease 2019 (COVID-19) Infection." Diseases 12, no. 2 (2024): 37. http://dx.doi.org/10.3390/diseases12020037.

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Introduction: This is a case report of a patient with neuropathic corneal pain after coronavirus disease 2019 (COVID-19) infection. Methods: A previously healthy 27-year-old female presented with bilateral eye pain accompanied by increased light sensitivity 5 months after COVID-19 infection. She was diagnosed with neuropathic corneal pain based on clear corneas without fluorescein staining, alongside the presence of microneuromas, dendritic cells, and activated stromal keratocytes identified bilaterally on in vivo confocal microscopy. Results: The patient’s tear nerve growth factor, substance

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