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Academic literature on the topic 'Coronary angiotomography'
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Journal articles on the topic "Coronary angiotomography"
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Patiño-Jaramillo, Nasly G., and Hector Medina. "Coronary angiotomography in the emergency department." Revista Colombiana de Cardiología 26 (July 2019): 142–48. http://dx.doi.org/10.1016/j.rccar.2018.08.007.
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Hernández-Mejía, Benjamín Iván, and Edison Ricardo Espinoza-Saquicela. "Giant right coronary artery aneurysm. Case Report." Case reports 6, no. 1 (2020): 70–76. http://dx.doi.org/10.15446/cr.v6n1.82446.
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Introduction: Coronary aneurysms are rare and are linked to drug abuse; symptomatology depends on the coronary anatomy. This is a case of acute coronary syndrome associated with a giant right coronary aneurysm.Case description: A 40-year-old male, with history of heroin and crack use since age 20, attended consultation due to dyspnea, stable angina and diaphoresis. An electrocardiogram showed ST segment overlay on the underside and troponin problems. A coronary catheterization was performed, which revealed apparent inconclusive aortato-right atrium fistula. Based on the findings, angiotomography and magnetic resonance imaging were performed, finding a giant right coronary aneurysm. The aneurysm was resected using extracorporeal circuit, femoral cannulation, moderate hypothermia, aortic cross-clamping and cardioplegia, and the right coronary artery was revascularized with the left internal saphenous vein. The patient had a satisfactory postoperative period and was discharged after 7 days.Conclusion: There is an important association between drug use and the development of coronary aneurysms. Aneurysm size makes diagnosis difficult, so complementary studies are necessary to establish a differential diagnosis. An appropriate surgical approach allows for a complete resection of the aneurysm and optimal coronary revascularization.
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Queiroz, Rodolfo Mendes, Rogério Nastri Filho, Marcus Antônio Ferez, Mauro José Brandão da Costa, Claudio Benedini Laguna, and Marcus Vinicius Nascimento Valentin. "Thrombosed aneurysm of saphenous vein coronary artery bypass grafting." Revista da Associação Médica Brasileira 63, no. 6 (2017): 488–91. http://dx.doi.org/10.1590/1806-9282.63.06.488.
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Summary We describe the case of a male patient, aged 76 years, referred for cardiac investigation due to retrosternal chest pain and dyspnea. He had a history of acute myocardial infarction and angioplasties in the last 30 years, including a saphenous vein coronary artery bypass grafting (SVCABG). Echocardiogram showed hypoechoic oval formation near the right ventricle, suggesting a pericardial cyst. Computed angiotomography revealed a predominantly fusiform and thrombosed aneurysmal dilation of the SVCABG to the right coronary artery. SVCABG aneurysms are very rare and potentially fatal. They usually appear in the late postoperative period, and patients are often asymptomatic. On radiography, it is frequently presented as enlargement of the mediastinum, with echocardiography, computed tomography and magnetic resonance imaging being very useful for diagnosis. Coronary angiography is the gold standard to detect these cases. Our report illustrates a rare situation arising late from a relatively common surgery. Due to its severity, proper recognition in the routine assessment of patients with a similar history is essential.
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Bravo-Valenzuela, Nathalie Jeanne Magioli, and Guilherme Ricardo Nunes Silva. "Aneurysm of the Left Coronary Artery in Postoperative Bland-White-Garland Syndrome." Case Reports in Cardiology 2015 (2015): 1–4. http://dx.doi.org/10.1155/2015/568014.
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We report a case of anomalous left coronary artery from the pulmonary artery (ALCAPA) or Bland-White-Garland syndrome, present the challenges of performing a differential diagnosis, and discuss the treatment of the syndrome. Although ALCAPA is a rare congenital heart disease, it is one of the most common causes of myocardial ischemia in childhood and presents a diagnostic challenge. A four-year-old girl was referred to a pediatric cardiologist for evaluation of mitral valve regurgitation murmur and heart failure. The transthoracic echocardiogram demonstrated the left coronary artery (LCA) not arising from the aorta, presence of coronary collateral circulation, and moderate mitral valve regurgitation. ALCAPA was confirmed using angiotomography. The LCA was surgically reimplanted into the aorta. After 3 years of postoperative follow-up, the patient developed an LCA aneurysm. Diagnosis of cardiac ischemia in childhood remains a challenge, and careful evaluation of coronary arteries on the echocardiogram is an important tool. In this report, we present a case of ALCAPA with an uncommon postoperative outcome.
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Muradas, Soraya Andrea Delefrate, Amanda Sayuri Nakamura, Jader Dornelas Neto, Taisa Valques Lorencete, Daniel Vicentini de Oliveira, and Mirian Ueda Yamaguchi. "Determining factors in the development of coronary plates and obstructions." ABCS Health Sciences 45 (October 22, 2020): e020015. http://dx.doi.org/10.7322/abcshs.45.2020.1340.
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Introduction: Coronary artery disease is the largest cause of mortality in the world. The main risk factors for its development include systemic arterial hypertension and type 2 diabetes mellitus. Objective: To search for predictors of the development of plaques and obstructions in coronary arteries and to determine whether the exercise test is a reliable pretest for coronary angiotomography. Methods: 883 computed tomography reports of coronaries were analyzed. Sociodemographic information, health conditions and results of the exercise test from patients were collected, along with calcium score, percentile and number of arterial segments with significant obstruction. The data were analyzed using descriptive and inferential statistics. Significance was considered for p<0.05. Results: It observed that the statistically significant predictors to the calcium score were male, being over 60 years old, having type 2 diabetes mellitus and systemic arterial hypertension. There was no relationship with high BMI and coronary obstruction. Regarding the exercise test, it was possible to observe that the majority of individuals who were positive in the exercise test, did not have a positive calcium score or significant coronary obstructions. Conclusion: The predictors for the development of coronary plaques and obstructions were male, aged ≥60 years, having type 2 diabetes mellitus and systemic arterial hypertension.
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Rodriguez-Reyna, T. S., M. Morelos-Guzman, P. Hernandez-Reyes, et al. "Assessment of myocardial fibrosis and microvascular damage in systemic sclerosis by magnetic resonance imaging and coronary angiotomography." Rheumatology 54, no. 4 (2014): 647–54. http://dx.doi.org/10.1093/rheumatology/keu350.
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Fontenele, Rafael Mondego, Tatiana De Almeida Souza, Darly Serra Cutrim, Joseane Moura Guedes, Josiel Freitas do Nascimento, and Rose Daiana Cunha dos Santos. "Eficácia de protocolos clínicos para o tratamento da dor torácica em serviços de urgência." Revista Recien - Revista Científica de Enfermagem 10, no. 32 (2020): 288–94. http://dx.doi.org/10.24276/rrecien2020.10.32.288-294.
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A dor torácica pode estar relacionada à síndrome coronariana, uma das principais causas de morte no Brasil. Os protocolos clínicos são diretrizes que visam o reconhecimento precoce e tratamento de agravos em rotina aprovada pela unidade assistencial. O objetivo do presente estudo foi identificar a eficácia de protocolos clínicos para o tratamento de dor torácica em unidades de urgência. Tratou-se uma revisão integrativa da literatura realizada nas bases científicas da Scielo e Lilacs a partir da combinação de descritores em ciências da saúde obtidos através do portal da Biblioteca Virtual em Saúde. Os principais exames realizados são eletrocardiograma, angiotomografia de coronárias e a cintilografia para a elucidação diagnóstica de síndromes coronarianas na presença de dor torácica. Concluiu-se que a incorporação de protocolos clínicos no ambiente hospitalar garante a segurança do paciente, orienta e direciona as condutas médicas para a prevenção de complicações como o óbito.Descritores: Dor no Peito, Socorro de Urgência, Emergências, Protocolos. Efficacy of clinical protocols for the treatment of chest pain in emergency servicesAbstract: Chest pain may be related to coronary syndrome, one of the main causes of death in Brazil. The clinical protocols are guidelines that aim at the early recognition and treatment of injuries in a routine approved by the care unit. The objective of the present study was to identify the efficacy of clinical protocols for the treatment of chest pain in emergency units. An integrative review of the literature on the scientific bases of Scielo and Lilacs was done based on the combination of descriptors in health sciences obtained through the Virtual Health Library portal. The main exams were electrocardiogram, coronary angiotomography and scintigraphy for the diagnostic elucidation of coronary syndromes in the presence of chest pain. It was concluded that the incorporation of clinical protocols in the hospital environment guarantees the patient's safety, directs and directs the medical conducts for the prevention of complications such as death.Descriptor: Chest Pain, Emergency Relief, Emergencies, Protocols. Eficacia de protocolos clínicos para el tratamiento del dolor torácico en servicios de urgenciaResumen: El dolor torácico puede estar relacionado con el síndrome coronario, una de las principales causas de muerte en Brasil. Los protocolos clínicos son directrices que apuntan al reconocimiento precoz y tratamiento de agravios en rutina aprobada por la unidad asistencial. El objetivo del presente estudio fue identificar la eficacia de protocolos clínicos para el tratamiento del dolor torácico en unidades de urgencia. Se trató una revisión integrativa de la literatura realizada en las bases científicas de Scielo y Lilacs a partir de la combinación de descriptores en ciencias de la salud obtenidos a través del portal de la Biblioteca Virtual en Salud. Los principales exámenes realizados son electrocardiograma, angiotomografía de coronarias y la centellografía para la elucidación diagnóstica de síndromes coronarios en presencia de dolor torácico. Se concluyó que la incorporación de protocolos clínicos en el ambiente hospitalario garantiza la seguridad del paciente, orienta y dirige las conductas médicas para la prevención de complicaciones como el óbito.Descriptores: Dolor em el Pecho, Socorro de Urgencia, Urgencias Médicas, Protocolos.
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Vassallo, Fabricio, Eduardo Serpa, Betina Reseck Walker, et al. "Initial Experience and Results of Combined Treatment for Atrial Fibrillation: Catheter Ablation with High-Power Short Duration Ablation and Left Atrial Appendage Closure." Journal of Cardiac Arrhythmias, no. 2 (May 22, 2021): 69–78. http://dx.doi.org/10.24207/jca.v34i2.3440.
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Introduction: Long-term freedom from atrial fibrillation (AF) after catheter ablation and, consequently, the potential for stroke reduction remain unpredictable. Recently, left atrial appendage closure (LAAC) became an effective mechanical alternative to oral anticoagulation (OAC) for stroke prevention in AF patients. Objective: This study aims to evaluate the feasibility and safety of combined treatment for AF with catheter ablation (CA) with the high-power short duration technique associated with LAAC in one single procedure. Methods: Patients with non-valvular AF who underwent combined CA and LAAC procedure were included in the retrospective observational study. Between April 2018 and October 2020, 13 patients with AF were included, eight (61,54%) males, eight (61.54%) with persistent AF (PersAF), mean age 68.54 (65–84) years old, mean time from AF diagnosis to treatment 13.08 (3–33) months, mean CHA2VASC2 5.08 (3–7), all patients with coronary or vascular disease, 12 (92.31%) with hypertension, five (38.46%) with left ventricular dysfunction, four (30.77%) prior strokes using OAC and four (30.77%) patients with diabetes. Indications for LAAC included history of contraindication to OAC because of severe bleeding in eight (61.54%), previous stroke in four (30.77%) and two (13.08%) patients with LAA thrombus, despite the use of two different OAC (one associated with bleeding). One patient had a pseudoaneurysm in femoral artery, and two patients died of non-procedure complications after 30 days. At six months, angiotomography showed successful complete sealing of the LAA in seven (77.72%) of nine patients evaluated, and the two patients without it had a leak of less than 2 mm. After mean follow-up of 14 months (five to 33), 10 (90.91%) of the 11 patients were in sinus rhythm. Three (27.27%) patients, one in blanking period, recovered sinus rhythm after amiodarone. No cardioembolic or bleeding events occurred. Conclusion: In this small observational study, we showed the feasibility and safety of the combined therapy with AF catheter ablation with LAAC with a high rate of sinus rhythm and no cardioembolic event.
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Vassallo, Fabricio. "Prevalence and Resolution of Resistant Left Atrial Appendage Thrombus in Non-Valvular Atrial Fibrillation Patients Submitted to Percutaneous Interventions." Clinical Cardiology and Cardiovascular Interventions 4, no. 8 (2021): 01–09. http://dx.doi.org/10.31579/2641-0419/161.
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Introduction: Left atrial appendage (LAA) thrombus in atrial tachyarrhythmias is one of the principal causes of stroke. Prevalence and strategies to thrombus resolution has recently been described in the era of the direct oral anticoagulants (DOAC). The aim of the study was to determine the prevalence and strategies to resolve previous LAA thrombus during regular oral antithrombotic therapy in preparation to perform atrial fibrillation (AF) ablation and/or LAA closure. Methods: Between January 2011 and December 2020 we prospectively followed 23 patients (5.39%) that showed LAA thrombus formation. Persistent AF occurred in 13 (56.52%), median age 72.39 years, 15 (65.22%) females, median CHA2DS2VASC of 4.13, HASBLED of 2.28, 17 (73.91%) with hypertension, (52.17%) with coronary disease, 9 (39.13%) had priors’ thromboembolic events, 7 (30.43%) with heart failure and Diabetes. Diagnosis was by transesophageal echocardiogram (TEE) in 20 (86.96%) and the rest by computed angiotomography. Rivaroxaban was used in 11 (47.83%), Dabigatran in 6 (26.09%), 5 (21.74%) with therapeutic range Warfarin and 1 (4.34%) with Apixaban. Main strategy of treatment was to change mechanism of action of antithrombotic medication in association to an antiplatelet drug, Clopidogrel 75mg a day, and perform a TEE at 90 days after. Results: Complete resolution of the LAA thrombus was achieved in 18 (78.26%) patients in first medical therapeutic change. Of the remaining a second approach with medical therapy adjustment with off-label dose prescription associated with Clopidogrel showed complete resolution in 3 (13.04%) totalizing a success rate of 91.30% for all patients (p value of 0.001 for treatment success). The failure of the antithrombotic plus antiplatelet therapy occurred in 2 (8.7%) patients, one with LAA sludge and other with a huge thrombus in all LAA and part of left atrium. Conclusion: Modification of the mechanism of action of direct oral anticoagulants in association with Clopidogrel demonstrates to be successful in a large number of patients with previous resistant left atrial thrombus with and secure since the low adverse event rates.
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Ker, Wilter dos Santos, Daniel Gama Neves, Alair Sarmet A. A. Damas, Cláudio Tinoco Mesquita, and Marcelo Souto Nacif. "Myocardial Bridge and Angiotomography of the Coronary Arteries: Perfusion under Pharmacological Stress." Arquivos Brasileiros de Cardiologia, 2017. http://dx.doi.org/10.5935/abc.20170021.
Full textDissertations / Theses on the topic "Coronary angiotomography"
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Schmal, Thaiz Ruberti. "Prevalência de lesão aterosclerótica coronariana e fatores associados em pacientes jovens, abaixo de 45 anos." Universidade Federal de Juiz de Fora, 2014. https://repositorio.ufjf.br/jspui/handle/ufjf/454.
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Previous issue date: 2014-05-22<br>Doença aterosclerótica coronariana (DAC) ainda é a principal causa de morte nos países ocidentais, apesar dos grandes avanços no seu diagnóstico e terapêutica nas últimas décadas. No Brasil, cerca de 30% dos óbitos são por doença cardiovascular, sendo que 50% ocorrem em adultos entre 30 e 69 anos de idade. A elevada mortalidade e morbidade da doença coronariana implicam em alto impacto socioeconômico, visto que tais casos incidem em sua maioria, sobre indivíduos economicamente ativos. A faixa etária mais frequentemente acometida é dos 50 aos 65 anos. Porém, tem-se observado um aumento significativo no número de casos em pacientes mais jovens. Neste trabalho analisamos um banco de dados de pacientes jovens, abaixo de 45 anos, que foram encaminhados para realização de angiotomografia coronariana para esclarecimento de quadro de dor torácica ou de exames provocativos alterados. Os objetivos eram estimar a prevalência de doença coronariana obstrutiva e não obstrutiva nessa população jovem local; estimar a correlação dos achados anatômicos com os fatores de risco para doença cardiovascular; discutir a validade do escore de cálcio para o rastreio de doença coronariana desta população, comparando-o aos resultados da angiotomografia coronariana. Inicialmente 181 pacientes foram identificados, mas 6 deles foram excluídos por apresentarem diagnóstico prévio de DAC. Os 175 pacientes incluídos foram analisados para presença de placa aterosclerótica na angiotomografia e quantificação do escore de cálcio. Foi feita uma correlação dos achados anatômicos com os fatores de risco para doença cardiovascular, inicialmente em análise bivariada a partir de cada fator com o desfecho e, posteriormente, em análise multivariada controlando pelos fatores associados mais significativos. Desta forma pode-se chegar às estimativas de prevalência para diferentes perfis de pacientes. A idade média foi de 38 ± 7 anos, sendo 76% homens. A prevalência de DAC foi estimada em 37,7%, sendo o exame normal em 109 pacientes (p < 0,001). Placas obstrutivas foram detectadas em 3,4% dos casos. Os pacientes eram sintomáticos em 60,6% dos casos, sendo a tomografia normal em 70,8% deles (p < 0,001). A análise dos fatores de risco mostrou significância estatística para presença dos fatores dislipidemia, tabagismo e sexo masculino. O escore de cálcio foi igual a zero em 147 pacientes, porém 38 apresentavam DAC. A sensibilidade para o método foi estimada em 42%, especificidade 100%, valor preditivo positivo 100% e valor preditivo negativo 74%. Os tipos de placas foram identificados, sendo observada a predominância de placas não calcificadas (p = 0,04). Os dados apontam que a prevalência de DAC em indivíduos jovens e do sexo masculino com fatores de risco para DAC não é desprezível. Portanto, medidas preventivas e de rastreamento dos fatores de risco devem ser iniciadas mais precocemente do que é recomendado atualmente pelo sistema de saúde público. Além disso, o escore de cálcio mostrou ser uma ferramenta diagnóstica de baixa sensibilidade e baixo valor preditivo negativo para pacientes jovens.<br>Coronary artery disease (CAD) is the main cause of mortality in developed countries despite the great advances in the diagnosis and treatment in the last years. In Brazil, 30% of all-cause mortality is related to cardiovascular disease and 50% of these patients are adults between 30 and 69 years-old. The high morbity and mortality implies an important economic burden to the country. The most affected ages are between 50 to 65 years old, but an increasing number of younger patients have been noticed. We analized the data of patients under 45 years old that underwent coronary angiotomography evaluation due to chest pain or altered provocative tests. Objectives: estimate the prevalence of coronary artery disease, and its correlation to known cardiovascular risk-factors; discuss the use of coronary calcium scoring as a tool in the diagnosis of coronary artery disease in young patients. Methods: 181 patients were identified but 6 of them were excluded due to previous diagnosis of coronary disease. In our study, 175 patients we enrolled and analyzed for the presence of atheromatous plaques in the coronary arteries and quantification of calcium scoring. The plaques burdens were correlated to the known cardiovascular risk factors in bivariate and multivariate analyses. The prevalence of CAD was estimated and correlated to the different risk factors. Results: the mean age was 38 ± 7 years old, and 76% were men. The prevalence of CAD was estimated in 37.7%, and 109 patients had normal results at the coronary angiiotomography (p < 0.001). Obstructive plaques were identified in 3.4% of the cases. 60.6% of the patients had symptoms but the exam was normal in 70.8% of these cases (p < 0.001). The risk factors that had statistical significance were hypercholesterolemia, smoking and male sex. The calcium scoring was zero in 147 patients, but 38 of them had CAD. The sensitivity of calcium scoring was estimated in 42%, specificity 100%, positive predictive value 100% and negative predictive value 74%. Non-calcified plaques were the most common type of atheromatous plaque (p = 0.04). Conclusion: We conclude that the prevalence of CAD in young male individuals with coronary risk factors is not so low. Early diagnosis of risk factors and preventive actions are necessary, even before the recommended age by our health system. Also, the calcium scoring seems not to be an adequate diagnostic tool in young patients due its low sensitivity and negative predictive value.
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Miname, Márcio Hiroshi. "Avaliação da aterosclerose subclínica coronariana e carotídea em portadores de hipercolesterolemia familiar: análise pela angiotomografia coronária, rigidez arterial e espessura íntima-média carotídea." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-12012011-161846/.
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A hipercolesterolemia familiar (HF) é uma doença autossômica dominante caracterizada por níveis elevados de LDL-c e doença arterial coronária (DAC) precoce. Existem evidências de maior prevalência de aterosclerose subclínica nesta população avaliada pelo escore de cálcio (CAC) e pela espessura íntima-média carotídea (EIMC). O objetivo do nosso estudo foi avaliar aterosclerose subclínica por meio da angiotomografia de coronárias em portadores de HF sem aterosclerose manifesta, correlacionando os achados com parâmetros clínicos, laboratoriais, rigidez aórtica e carotídea e com a EIMC. Incluímos 102 HFs, (45±13 anos, 36% homens, LDL-c 280±54mg/dL) e 35 controles (46±12 anos, 40% homens, LDL-c 103±18mg/dL). O grupo HF apresentava maior carga de placa aterosclerótica representado por: maior número de pacientes com placa (48% versus 14%, p=0,0005), maior número de pacientes com estenose luminal acima de 50% (19% versus 3%, p=0,015), maior número total de segmentos com placas (2,0±2,8 versus 0,4±1,3, p=0,0016), maior número de segmentos com placas calcificadas (0,8±1,54 versus 0,11±0,67, p= 0,0044) e maior escore de cálcio pelo método de Agatston (55±129, mediana:0 versus 38±140, mediana:0; p=0,0028). Houve correlação positiva no grupo HF do número total de segmentos com placa com: idade (r=0,41, p<0,0001), escore de risco de Framingham (r=0,25, p=0,012), colesterol total (r=0,36, p<0,0002), LDL-c (r=0,27, p=0,005), HDL-c (r=0,24, p=0,017), apolipoproteína B (r=0,3, p=0,0032) e escore de cálcio (r=0,93, p<0,0001). Além disso, houve correlação negativa com: variação sísto-diastólica carotídea (r=-0,23, p=0,028) e percentual de distensão carotídeo (r=-0,24, p=0,014). A análise multivariada de determinantes da presença de placa aterosclerótica, revelou que idade (OR=1,105, IC95%: 1,049-1,164, p<0,001) e colesterol total (OR=1,013, IC95%:1,001-1,025) foram as variáveis associadas com a presença da mesma. A única variável associada com presença de obstrução luminal acima de 50% foi o escore de cálcio coronário (OR=1,004; IC95%:1,001-1,008; p=0,014). Em relação a determinantes da composição de placa, na análise multivariada a presença de placa não calcificada esteve associada com o sexo masculino (OR:15,45; IC95%: 1,72-138,23, p=0,014), a placa mista com antecedente familiar de DAC precoce (OR=4,90; IC95%:1,32-18,21, p=0,018) e placa calcificada a menor chance com o sexo masculino (OR=0,21; IC95%: 0,05-0,84, p=0,027). Conclusões: Os pacientes portadores de HF apresentam maior carga de placa avaliada pela angiotomografia em comparação aos controles; idade e colesterol total associaram-se a presença de placas no grupo HF; o escore de cálcio associou-se a presença de estenose luminal acima de 50%.<br>Familial hypercholesterolemia (FH) is an autosomal dominant disease characterized by high LDL-c levels and premature coronary artery disease (CAD) onset. There is evidence of greater prevalence of subclinical atherosclerosis in this population evaluated by coronary calcium score (CCS) and carotid intima-media thickness (IMT). The aim of our study was to assess subclinical atherosclerosis by computed tomography coronary angiography (CTCA) in patients with FH without manifest atherosclerosis and correlate the findings with clinical and laboratory parameters, aortic and carotid stiffness and IMT. We included 102 FHs (45 ± 13 years, 36% men, LDL-c 280 ± 54mg/dL) and 35 controls (46 ± 12 years, 40% men, LDL-c 103 ± 18mg/dL). The FH group had a greater atherosclerosis plaque burden represented by: higher number of patients with coronary plaque (48% versus 14%, p = 0.0005) and with luminal stenosis greater than 50% (19% versus 3% p = 0.015), higher total number of segments with plaques (2.0 ± 2.8 versus 0.4 ± 1.3, p = 0.0016), higher number of segments with calcified plaques (0.8 ± 1.54 versus 0.11 ± 0.67, p = 0.0044) and higher CCS by the Agatston method (55 ± 129, median: 0 vs. 38 ± 140, median = 0, p = 0.0028). There were positive correlations of total number of segments with plaque in FH group with the following variables: age (r=0.41, p<0.0001), Framingham risk score (r =0.25, p=0.012), total cholesterol (r=0.36, p<0.0002), LDL-c (r=0.27, p=0.005), HDL-c (r=0.24, p=0.017), apolipoprotein B (r=0,3, p=0.0032) and CCS (r=0.93, p<0.0001). In addition there was a negative correlation with: carotid systo-diastolic variation (r=- 0.23, p=0.028) and percentage of carotid distension (r=- 0.24, p=0.014). After multivariate analysis, the determinants of plaque presence were age (OR=1.105, 95% CI=1.049-1.164, p<0.001) and total cholesterol (OR=1.013, 95% CI:1.001-1.025). The only variable associated with presence of luminal stenosis greater than 50% was CCS (OR = 1.004, 95% CI: 1.001-1.008, p=0.014). After multivariate analysis, the presence of non-calcified plaque was associated with male gender (OR: 15.45, 95% CI 1.72-138.23, p = 0.014), mixed plaque with family history of early CAD (OR = 4.90, 95%:1.32-18.21, p=0.018) and calcified plaque negatively with males (OR = 0.21, 95% CI: 0.05-0.84, p = 0.027). Conclusions: FH subjects have higher plaque burden assessed by CTCA compared to controls; age and total cholesterol were associated with the presence of coronary plaque in the FH subjects; CCS was associated with luminal stenosis greater than50%.