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Dissertations / Theses on the topic 'Cortex insular'

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1

Rogers-Carter, Morgan M. "TheRole of the Insular Cortex in Rodent Social Affective Behavior:." Thesis, Boston College, 2019. http://hdl.handle.net/2345/bc-ir:108375.

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Thesis advisor: John P. Christianson<br>In social species, animals must detect, evaluate and respond to the states of other individuals in their group. A constellation of gestures, vocalizations, and chemosignals enable animals to convey affect and arousal to others in nuanced, multisensory ways. Observers integrate such social information with environmental cues and internal physiology to general social behavioral responses via a process called social decision-making. The mechanisms and anatomical correlates of social decision-making, particularly those that allow behavioral responses to othe
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2

Jones, Catherine Louise. "The role of insular cortex in the integration of emotion, perception and cognition." Thesis, University of Brighton, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.590010.

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Influential models highlight that insular cortex integrates cognitive, affective, sensorimotor and autonomic signals to create unified perceptual experiences or "feeling states". One challenge in developing a satisfactory neuropsychological model of insula function is to account for its involvement across these different domains which require access across multiple functional circuits. This thesis combines behavioural, psychophysiological, functional neuroimaging and lesion methods to inform and extend current models of integration in the insula. In the first two experimental chapters, the int
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3

Gehrlach, Daniel [Verfasser], and Rüdiger [Akademischer Betreuer] Klein. "Anatomical and functional characterization of the mouse insular cortex / Daniel Gehrlach ; Betreuer: Rüdiger Klein." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1216039178/34.

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4

Cosme, Caitlin Victoria. "The role of the prefrontal cortex in cocaine and heroin seeking following extinction training." Diss., University of Iowa, 2017. https://ir.uiowa.edu/etd/5924.

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The prefrontal cortex (PFC) is considered a critical node in the neural circuitry underlying drug-seeking behaviors. However, the mechanisms by which this region influences drug seeking and whether or not the lateral PFC mediates cocaine or heroin seeking are questions that have yet to be answered. To expand on the role of the PFC in drug seeking, rats were trained on either heroin or cocaine self-administration for a minimum of 12 days before undergoing extinction training and subsequent reinstatement tests (cued and drug-prime). All pharmacological manipulations were delivered immediately pr
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5

Almashaikhi, Talal. "Electrical brain stimulation and human insular connectivity." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10174/document.

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Le cortex insulaire est le cinquième lobe du cerveau en charge de l'intégration de nombreuses fonctions cognitives, sous-tendues par une organisation cytoarchitectonique etune connectivité aussi riche que complexe. Ce travail vise à évaluer la connectivité fonctionnelle insulaire du cerveau humain par le biais de stimulation électrique intra-cérébrale et de potentiels évoqués cortico-corticaux (PECC) réalisés chez des patients explorés en stéréoélectroencéphalographie (SEEG) pour une épilepsie partielle réfractaire. Nous avons développé un protocole automatisé permettant destimuler successivem
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6

Foilb, Allison R. "Sex Differences and the Neural Correlates of Safety Learning:." Thesis, Boston College, 2019. http://hdl.handle.net/2345/bc-ir:108467.

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Thesis advisor: John P. Christianson<br>Accurate discrimination between safety and danger is necessary for survival, but is aberrant in individuals with post-traumatic stress disorder (PTSD). Despite its clinical relevance, very little is known about the cognitive and neural processes that underlie safety learning. Understanding how cues become safety signals is critical to understanding the impairments in fear modulation observed in individuals with PTSD. PTSD is more prevalent in women than men, and while research on sex differences in safety learning is limited, there is substantial evidenc
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7

Bradley, Claire. "The first steps of cortical somatosensory and nociceptive processing in humans : anatomical generators, functional plasticity, contribution to sensory memory and modulation by cortical stimulation." Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10213.

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Les sensations en provenance de notre corps se combinent pour donner lieu à des perceptions extrêmement variées, pouvant aller de la brûlure douloureuse au toucher agréable. Ces deux types d'informations dites nociceptives et non nociceptive sont traitées au sein du système nerveux somatosensoriel. Dans ce travail de thèse, nous avons modélisé et caractérisé l'activité électrique du cortex operculo-insulaire au sein des réseaux somatosensoriels non-douloureux et nociceptif, grâce à des enregistrements non-invasifs chez l'Homme. La validité du modèle en réponse à un stimulus nociceptif a été év
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8

Bouchatta, Otmane. "Sensibilisation à la douleur chez un modèle murin de troubles du déficit de l'attention et de l'hyperactivité." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0356/document.

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L’ADHD (Attention-deficit/hyperactivity disorder) est une maladie du développement caractérisée par l’impulsivité, l’hyperactivité, et l’inattention. Les voies neuronales impliquées dans ces déficits indiquent des dysfonctionnements dans les réseaux catécholaminergiques frontal-sous-corticaux, impliquant l'innervation dopaminergique et noradrénergique. Des études récentes ont mis en évidence une hypersensibilité à la douleur chez les patients ADHD et soulignent une possible comorbidité entre l’ADHD et la douleur. Cependant, les mécanismes et les circuits neuraux impliqués dans ces interactions
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9

Brooks, Samantha J., Jonathan Cedernaes, and Helgi B. Schiöth. "Increased prefrontal and parahippocampal activation with reduced dorsolateral prefrontal and insular cortex activation to food images in obesity : a meta-analysis of fMRI studies." Uppsala universitet, Funktionell farmakologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-199757.

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BACKGROUND AND OBJECTIVES: Obesity is emerging as the most significant health concern of the twenty-first century. A wealth of neuroimaging data suggest that weight gain might be related to aberrant brain function, particularly in prefrontal cortical regions modulating mesolimbic addictive responses to food. Nevertheless, food addiction is currently a model hotly debated. Here, we conduct a meta-analysis of neuroimaging data, examining the most common functional differences between normal-weight and obese participants in response to food stimuli. DATA SOURCE: We conducted a search using severa
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10

Ferrier, Jeremy. "Douleurs neuropathiques induites par l'oxaliplatine. Physiopathologie et approches thérapeutiques." Thesis, Clermont-Ferrand 1, 2013. http://www.theses.fr/2013CLF1PP06/document.

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L’oxaliplatine, anticancéreux utilisé pour le traitement du cancer colorectal, est responsable d’une neurotoxicité périphérique dose-limitante affectant une grande majorité de patients. La neurotoxicité de l’oxaliplatine se présente sous deux formes : une forme immédiate, se traduisant par des paresthésies transitoires, et une forme retardée et cumulative, caractérisée par l’apparition d’une neuropathie périphérique douloureuse fortement invalidante. A l’heure actuelle, la prise en charge des douleurs neuropathiques est souvent incomplète, principalement à cause du manque de traitements effica
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11

Horn, Felicitas Marietta [Verfasser], and Henry [Akademischer Betreuer] Evrard. "Elemental localization of the von Economo neuron and fork neuron in the insular cortex in humans and macaque monkeys / Felicitas Marietta Horn ; Betreuer: Henry Evrard." Tübingen : Universitätsbibliothek Tübingen, 2020. http://d-nb.info/1205313443/34.

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12

Lee, Woogul. "Neural substrates of intrinsic motivation: fMRI studies." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/2738.

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Numerous social and educational psychologists propose that intrinsic motivation generated by personal interests and spontaneous satisfactions is qualitatively different from extrinsic types of motivation generated by external compensations and also that intrinsic motivation is more beneficial to learning than extrinsic types of motivation. However, in the field of neuroscience, intrinsic motivation has been little studied while extrinsic types of motivation (e.g., incentive motivation) have been thoroughly studied. The purpose of the present studies was to expand the neural understanding of mo
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13

Zhao, Zhe. "Le rôle du récepteur des cannabinoïde de type 1 dans la consommation d'eau." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0319.

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L’apport hydrique est crucial pour le maintien homéostatique des fluides corporels et pour la survie de l’animal. Des processus cérébraux complexes déclenchent la soif, qui survient suite à une perte de volume sanguin (déshydratation extracellulaire) ou une augmentation de l’osmolalité sanguine (déshydratation intracellulaire), afin d’apporter de l’eau pour l’équilibre des fluides. Cependant, les mécanismes centraux favorisant la prise hydrique sont encore peu caractérisés. Les récepteurs aux cannabinoïdes de type 1 (CB1) sont exprimés de manière large et abondante dans le système nerveux cent
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14

Chapuis, Julie. "Les circuits neuronaux de l'aversion olfactive conditionnée : approche électrophysiologique chez le rat vigile." Phd thesis, Université Claude Bernard - Lyon I, 2009. http://tel.archives-ouvertes.fr/tel-00603782.

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L'objectif de cette thèse est de décrire le réseau cérébral et la dynamique neuronale qui pourraient servir de support aux aversions alimentaires de type olfactives. Nous avons réalisé des enregistrements multisites de potentiel de champ locaux chez le rat vigile engagé dans cet apprentissage, en proposant deux modes de présentation de l'indice olfactif : à proximité de l'eau de boisson (distal) ou ingéré (distal-proximal). Après apprentissage, la présentation du seul indice distal induit l'émergence d'une activité oscillatoire de forte amplitude dans la bande de fréquence beta (15-40 Hz). Fin
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15

Smith, Mark Allan. "An investigation into the gating properties of rat cortex neuronal BK channels." Thesis, University of Aberdeen, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322636.

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In this thesis it is demonstrated that leptin and insulin hyperpolarise hypothalamic glucose responsive neurones via the activation of the large conductance ATP-sensitive (K<sub>APT</sub>) channel. This channel was potassium selective, had a single channel conductance of 150 pS and channel activity was inhibited by micromolar tolbutamide and millimolar internal ATP. Brain cortical cell bodies and nerve terminals possess a large-conductance calcium-activated potassium (BK) channel. The nerve terminal BK channel switched from high to low activity modes, whereas cell body BK channel activity inac
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16

Mazzola, Laure. "ROLE DU CORTEX OPERCULO-INSULAIRE DANS LA SOMESTHESIE ET LA DOULEUR CHEZ L'HOMME." Phd thesis, Université Claude Bernard - Lyon I, 2011. http://tel.archives-ouvertes.fr/tel-00793586.

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Ce travail de thèse a pour objectif de préciser le rôle du cortex operculo-insulaire dans la somesthésie et la douleur chez l'Homme à l'aide d'études réalisées par stimulations électriques intracérébrales et en IRM fonctionnelle (IRMf). Deux secteurs fonctionnels distincts ont été mis en évidence; d'une part l'insula dont 60% des stimulations induisent des réponses somato-sensitives dont 10% sont douloureuses, où il existe une localisation préférentiellement postérieure des sites de stimulation donnant lieu à une réponse douloureuse et un décrément antéro-postérieur du seuil de déclenchement d
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17

ATTIA, ALY SAAD MOHAMED AHDY. "Consequences d'une ischemie du cortex insulaire sur la fonction baroreflexe cardiaque du rat." Paris 6, 1989. http://www.theses.fr/1989PA066016.

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Cette etude precise la fonction cardiaque du baroreflexe apres une ischemie sylvienne gauche provoquant une lesion insulaire chez le rat. L'analyse est realisee pharmacologiquement selon la technique du steady state et sur une echelle large de variations tensionnelles chez le rat conscient
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18

Mazzola, Laure. "Rôle du cortex operculo-insulaire dans la somesthésie et la douleur chez l'homme." Thesis, Lyon 1, 2011. http://www.theses.fr/2011LYO10208/document.

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Ce travail de thèse a pour objectif de préciser le rôle du cortex operculo-insulaire dans la somesthésie et la douleur chez l'Homme à l'aide d'études réalisées par stimulations électriques intracérébrales et en IRM fonctionnelle (IRMf). Deux secteurs fonctionnels distincts ont été mis en évidence; d'une part l'insula dont 60% des stimulations induisent des réponses somato-sensitives dont 10% sont douloureuses, où il existe une localisation préférentiellement postérieure des sites de stimulation donnant lieu à une réponse douloureuse et un décrément antéro-postérieur du seuil de déclenchement d
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19

Frot, Maud Gaëlle. "Réponses nociceptives et somesthésiques des cortex operculaire supra-sylvien et insulaire chez l'homme : étude électrophysiologique par enregistrements intra-cérébraux." Lyon 1, 2001. http://www.theses.fr/2001LYO1T028.

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20

Shaw, Lynda Joan. "Emotional processing of natural visual images in brief exposures and compound stimuli : fMRI and behavioural studies." Thesis, Brunel University, 2009. http://bura.brunel.ac.uk/handle/2438/3203.

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Can the brain register the emotional valence of brief exposures of complex natural stimuli under conditions of forward and backward masking, and under conditions of attentional competition between foveal and peripheral stimuli? To address this question, three experiments were conducted. The first, a behavioural experiment, measured subjective valence of response (pleasant vs unpleasant) to test the perception of the valence of natural images in brief, masked exposures in a forward and backward masking paradigm. Images were chosen from the International Affective Picture System (IAPS) series. A
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21

Chaddad, Neto Feres Eduardo Aparecido. "Estudo das caracteristicas morfologicas do lobo da insula em pacientes portadores de epilepsia do lobo temporal medial." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309216.

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Orientador: Evandro Pinto da Luz de Oliveira<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-06T17:08:11Z (GMT). No. of bitstreams: 1 ChaddadNeto_FeresEduardoAparecido_M.pdf: 5740692 bytes, checksum: 41706f7c50d8c3c6567a1c592112c6e0 (MD5) Previous issue date: 2006<br>Resumo: A epilepsia do lobo temporal medial é o subtipo mais freqüente de epilepsia do lobo temporal e é causada, principalmente, pela esclerose medial temporal (EMT). A EMT é caracterizada pela esclerose hipocampal e diferentes graus de acometim
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Desgranges, Bertrand. "Etude des apprentissages olfactifs alimentaires : importance de l'amygdale basolatérale et du cortex insulaire chez le rat." Thesis, Tours, 2009. http://www.theses.fr/2009TOUR4004/document.

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Dans la perspective de mieux comprendre les mécanismes impliqués dans les apprentissages olfactifs alimentaires, nous avons investigué les bases neurobiologiques de l’aversion olfactive conditionnée (AOC) et de la préférence olfactive conditionnée (POC). Nous nous sommes intéressés au rôle joué par deux structures de convergence des informations olfactives, gustatives et viscérales, le noyau basolatéral de l’amygdale (NBL) et le cortex insulaire (CI). Une approche pharmacologique nous permet de montrer que le NBL est indispensable à l’acquisition, la consolidation et le rappel de l’AOC. A cont
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23

Gueguen, Maëlle. "Dynamique intracérébrale de l'apprentissage par renforcement chez l'humain." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAS042/document.

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Chaque jour, nous prenons des décisions impliquant de choisir les options qui nous semblent les plus avantageuses, en nous basant sur nos expériences passées. Toutefois, les mécanismes et les bases neurales de l’apprentissage par renforcement restent débattus. D’une part, certains travaux suggèrent l’existence de deux systèmes opposés impliquant des aires cérébrales corticales et sous-corticales distinctes lorsque l’on apprend par la carotte ou par le bâton. D’autres part, des études ont montré une ségrégation au sein même de ces régions cérébrales ou entre des neurones traitant l’apprentissag
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Smith, Ryan, Richard D. Lane, Anna Alkozei, et al. "Maintaining the feelings of others in working memory is associated with activation of the left anterior insula and left frontal-parietal control network." OXFORD UNIV PRESS, 2017. http://hdl.handle.net/10150/625065.

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The maintenance of social/emotional information in working memory (SWM/EWM) has recently been the topic of multiple neuroimaging studies. However, some studies find that SWM/EWM involves a medial frontal-parietal network while others instead find lateral frontal-parietal activations similar to studies of verbal and visuospatial WM. In this study, we asked 26 healthy volunteers to complete an EWM task designed to examine whether different cognitive strategies- maintaining emotional images, words, or feelings- might account for these discrepant results. We also examined whether differences in EW
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25

Naqvi, Nasir Hasnain. "The effects of lesions in the ventromedial prefrontal cortex and related areas on emotional responses to cigarette smoking." Diss., University of Iowa, 2007. http://ir.uiowa.edu/etd/173.

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26

Lueken, Ulrike, Johann Daniel Kruschwitz, Markus Muehlhan, Jens Siegert, Jürgen Hoyer, and Hans-Ulrich Wittchen. "How specific is specific phobia? Different neural response patterns in two subtypes of specific phobia." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-112819.

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Specific phobia of the animal subtype has been employed as a model disorder exploring the neurocircuitry of anxiety disorders, but evidence is lacking whether the detected neural response pattern accounts for all animal subtypes, nor across other phobia subtypes. The present study aimed at directly comparing two subtypes of specific phobia: snake phobia (SP) representing the animal, and dental phobia (DP) representing the blood-injection-injury subtype. Using functional magnetic resonance imaging (fMRI), brain activation and skin conductance was measured during phobogenic video stimulation in
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Costa, Vinícius Pelarin do Nascimento. "Empatia em camundongos: avaliação do papel da amídala, insula e córtex cingulado anterior na nocicepção em camundongos expostos ao teste de contorções abdominais." Universidade Federal de São Carlos, 2014. https://repositorio.ufscar.br/handle/ufscar/1376.

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Made available in DSpace on 2016-06-02T19:23:02Z (GMT). No. of bitstreams: 1 6369.pdf: 1124310 bytes, checksum: 0ca17967bc2f98ad5efcffdb78af91d5 (MD5) Previous issue date: 2014-05-09<br>Universidade Federal de Minas Gerais<br>Empathy can be defined as the capacity for perceive emotional signals from others. Among these signals, the ability to perceive pain has clear adaptive and evolutionary value. Pain can be defined as a subjective experience that includes sensorial, emotional and cognitive components. Evidence has emphasized the role of amygdala, anterior cingulate cortex (ACC) and insula
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Zheng, Qi. "Performance Characterization of Silicon-On-Insulator (SOI) Corner Turning and Multimode Interference Devices." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23234.

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Silicon-on-insulator (SOI) technology has become increasingly attractive because of the strong light confinement, which significantly reduces the footprint of the photonic components, and the possibility of monolithically integrating advanced photonic waveguide circuits with complex electronic circuits, which may reduce the cost of photonic integrated circuits by mass production. This thesis is dedicated to numerical simulation and experimental performance measurement of passive SOI waveguide devices. The thesis consists of two main parts. In the first part, SOI curved waveguide and corner tur
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Lueken, Ulrike, Johann Daniel Kruschwitz, Markus Muehlhan, Jens Siegert, Jürgen Hoyer, and Hans-Ulrich Wittchen. "How specific is specific phobia? Different neural response patterns in two subtypes of specific phobia." Technische Universität Dresden, 2011. https://tud.qucosa.de/id/qucosa%3A26867.

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Specific phobia of the animal subtype has been employed as a model disorder exploring the neurocircuitry of anxiety disorders, but evidence is lacking whether the detected neural response pattern accounts for all animal subtypes, nor across other phobia subtypes. The present study aimed at directly comparing two subtypes of specific phobia: snake phobia (SP) representing the animal, and dental phobia (DP) representing the blood-injection-injury subtype. Using functional magnetic resonance imaging (fMRI), brain activation and skin conductance was measured during phobogenic video stimulation in
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Sawamoto, Nobukatsu. "Expectation of pain enhances responses to nonpainful somatosensory stimulation in the anterior cingulate cortex and parietal operculum/posterior insula : an event-related functional magnetic resonance imaging study." Kyoto University, 2001. http://hdl.handle.net/2433/150507.

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31

Chiarovano, Elodie. "Instabilité posturale chez les séniors : dysfonction vestibulaire périphérique ou centrale ?" Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCB006.

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L’instabilité posturale est fréquente chez les séniors et peut entrainer la chute. La chute chez les séniors est un problème majeur de santé publique. Les chiffres épidémiologiques sont éloquents : une personne sur trois âgées de plus de 70 ans fera une chute dans l’année. Les causes sont multifactorielles : ostéo-articulaire, visuelle, cognitive, vestibulaire…. Dans cette étude, nous nous sommes intéressés à l’évolution de la fonction des récepteurs vestibulaires périphériques avec l’âge et à la perception de rotation à partir des entrées canalaires horizontales (système vestibulaire central
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Endres, Ralph Julian Verfasser], Ulrike [Gutachter] Lüken, and Marcel [Gutachter] [Romanos. "Networks of fear: Functional connectivity of the amygdala, the insula and the anterior cingulate cortex in two subtypes of specific phobia / Ralph Julian Endres ; Gutachter: Ulrike Lüken, Marcel Romanos." Würzburg : Universität Würzburg, 2019. http://d-nb.info/1187140546/34.

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Fall, Anna. "Rôles différentiels du cortex cingulaire antérieur sous-génual et de l'insula antérieure dans la régulation des conséquences socio-affectives de l'exclusion sociale chez le rat." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS097.

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Les humains sont motivés par un besoin fondamental de maintenir des relations stables et durables. De nombreuses études comportementales ont démontré que l’exclusion sociale menace ce besoin fondamental d’appartenance. Au niveau neuronal, il a été mis en évidence l’implication du cortex cingulaire antérieur sous génual (CCAsg) et de l’insula antérieure (AI), deux régions aussi impliquées dans la dépression majeure, où le rejet social constitue un facteur de risque établi. A ce jour, le rôle du CCAsg et de l’AI dans les processus d’intégration et de régulation de l’exclusion sociale reste cepen
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Musselmann, Kurt. "Developing culture conditions to study keratocyte phenotypes in vitro." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001726.

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Penin, Lucie. "Maintien des populations de coraux Scléractiniaires en milieu insulaire fragmenté (archipel de la Société, Polynésie française) : influence du recrutement et de la mortalité post-fixation." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2007. http://tel.archives-ouvertes.fr/tel-00743644.

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De façon à améliorer la compréhension des mécanismes de maintien des populations de Scléractiniaires en milieu insulaire fragmenté, l'influence des variations du recrutement, d'une part, et de la mortalité post-recrutement, d'autre part, sur la structure des peuplements juvéniles et adultes a été explorée. Pour cela, dans un premier temps, la variabilité spatio-temporelle du recrutement a été caractérisée à l'échelle insulaire sur 5 ans autour de Moorea et à l'échelle régionale sur 1 an dans l'archipel de la Société (Polynésie française) de façon à mener des analyses spatio-temporelles à multi
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Della, Corte Karen Aimee [Verfasser]. "Dietary sugar intake: International time trends in intake levels among children and adolescents and aspects of its relevance for subclinical inflammation and insulin sensitivity among adults / Karen Aimee Della Corte." Paderborn : Universitätsbibliothek, 2021. http://d-nb.info/1230468323/34.

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Duarte, Marcio de Souza. "Desempenho e qualidade de carne em novilhas de corte alimentados com dois níveis de concentrado e proteína não degradável no rúmen e influência da maturidade fisiológica sobre parâmetros qualitativos da carcaça e da carne bovina." Universidade Federal de Viçosa, 2010. http://locus.ufv.br/handle/123456789/5659.

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Mishura, Daria [Verfasser], Cornelius [Akademischer Betreuer] Bollheimer, and Cornel [Gutachter] Sieber. "Untersuchungen zum Einfluss der Stoffwechselhormone Adiponektin, Insulin und Leptin auf die ernährungsabhängige Entwicklung von Sarkopenie im präklinischen Modell der alternden Hochfettratte / Daria Mishura ; Gutachter: Cornel Sieber ; Betreuer: Cornelius Bollheimer." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2019. http://d-nb.info/1184023832/34.

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Almeida, Madson Queiroz de. "Expressão dos genes IGF-II, IGF-IR, SF-1 e DAX-1 em tumores adrenocorticais de crianças e adultos." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-31102008-153148/.

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Introdução: A patogênese molecular dos tumores adrenocorticais é heterogênea e ainda pouco compreendida. A hiperexpressão do gene do fator de crescimento semelhante à insulina II (IGF-II) tem sido demonstrada na maioria dos carcinomas adrenocorticais em adultos. Os efeitos mitogênicos do IGF-II são mediados pela interação com o receptor de IGF-I (IGF-IR). Adicionalmente, o fator esteroidogênico 1 (SF-1) e o fator codificado por uma região crítica do cromossomo X associada ao sexo reverso e à hipoplasia adrenal congênita (DAX-1), ambos envolvidos no desenvolvimento e na esteroidogênese adrenal,
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Cabral, Diogo da Cunha. "Neurosurgical anatomy of the insular cortex." Dissertação, 2019. https://hdl.handle.net/10216/128912.

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OBJETIVOS: Com este estudo procurámos clarificar e aprofundar o conhecimento existente sobre a morfologia do córtex insular, focando-nos não só na forma da ínsula, como também na organização dos seus sulcos e circunvoluções. MATERIAIS E MÉTODOS: Após a devida exposição, as ínsulas de sessenta hemisférios humanos adultos previamente fixados em formaldeído foram fotografadas. As dimensões de cada circunvolução e de cada sulco foram medidas com recurso a um software de análise de imagem. Os dados morfométricos obtidos foram depois analisados estatisticamente. RESULTADOS: A forma do córtex insu
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Cabral, Diogo da Cunha. "Neurosurgical anatomy of the insular cortex." Master's thesis, 2019. https://hdl.handle.net/10216/128912.

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OBJETIVOS: Com este estudo procurámos clarificar e aprofundar o conhecimento existente sobre a morfologia do córtex insular, focando-nos não só na forma da ínsula, como também na organização dos seus sulcos e circunvoluções. MATERIAIS E MÉTODOS: Após a devida exposição, as ínsulas de sessenta hemisférios humanos adultos previamente fixados em formaldeído foram fotografadas. As dimensões de cada circunvolução e de cada sulco foram medidas com recurso a um software de análise de imagem. Os dados morfométricos obtidos foram depois analisados estatisticamente. RESULTADOS: A forma do córtex insu
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Vignovich, Martin Nicholas. "Integration of Taste and Odor in Agranular Insular Cortex." Thesis, 2019. https://doi.org/10.7916/d8-qdv7-q834.

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Our perception of the world is limited by the senses we are endowed with. In the case of taste, its functional fidelity is so critical for our survival that we come into the world with innate preference for sweet and disgust for bitter. These stereotyped behaviors are hardwired at the lowest levels of taste processing and they support the view that taste serves as an arbiter of the chemical world, passing judgement before permitting ingestion. Yet our experience of foods is manifold. This complexity results from distinct contributions from the sights, sounds and smells of the foods we consume.
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Gomes, Ana Manuel Macedo Veiga. "Insular cortex structural variability and individual differences in empathic traits." Master's thesis, 2016. http://hdl.handle.net/1822/42266.

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Dissertação de mestrado integrado em Psicologia<br>This study aims to investigate associations between individual differences in empathy and structural variations in the insular cortex, particularly in the anterior insula (AI). A normative sample of 31 male subjects was selected from the community, ranging from the ages of 20 to 40 years old. Individual differences on empathy were assessed through the Questionnaire of Cognitive and affective Empathy (QCAE). Measures of grey matter volume, area, cortical thickness and white matter volume were extracted from T1-Wheighted structural MRI scans wit
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Yeh, Han-Yuan, and 葉瀚元. "The Role of Posterior Insular Cortex in Rat Model of Neuropathic Pain." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/42719224738618799550.

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碩士<br>國立臺灣大學<br>動物學研究所<br>101<br>Neuropathic pain is an intractable disease in daily life and clinical research. It can result in long-term changes in central nervous system. Insular cortex is a brain region participated in processing of different sensory modalities. Evidences have also shown that posterior insular cortex may be related to somatosensory perception especially in nociception. However, the role for how PIC contributes to the initiation or maintenance of neuropathic pain is less understood. In the present study, permanent lesion by NMDA excitotoxicity in PIC was used to assess the
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Carvalho, Daniela Brum de. "Organization of the precise connectivity between mouse basomedial amygdala and insular cortex." Master's thesis, 2018. http://hdl.handle.net/10316/86148.

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Dissertação de Mestrado em Biologia Celular e Molecular apresentada à Faculdade de Ciências e Tecnologia<br>Estudos recentes têm indicado que o córtex da insula (IC) é uma região cerebral com um papel preponderante no processamento de emoções, incluindo medo e ansiedade. Acredita-se que esta e outras funções, tais como aprendizagem de sinais que transmitem segurança, previsão de risco e antecipação, são executadas juntamente com a amígdala, uma área que, tal como o IC, se encontra também desregulada em distúrbios de ansiedade. Esta hipótese é também suportada por evidências de estudos convenci
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Pereira, Filipa Silveira Monteiro da Gama 1986. "Insular cortex as a link between brain and heart: an electrophysiological approach." Master's thesis, 2011. http://hdl.handle.net/10451/4689.

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Tese de mestrado. Biologia (Biologia Humana e Ambiente). Universidade de Lisboa, Faculdade de Ciências, 2011<br>No dia-a-dia o Homem está sujeito a situações stressantes que põem em causa a sua sobrevivência, afectando-o física e emocionalmente, podendo contribuir para o aparecimento de algumas patologias. Na resposta a estas situações, o cérebro desempenha uma função preponderante. É ele que determina quais as situações que são consideradas ameaçadoras e que desencadeia a resposta fisiológica perante essas ameaças. A resposta a situações de stress está muito dependente do eixo hipotálamo-pitu
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Teodósio, Ana Marta Capaz Assunção de Vasconcelos. "Role of Insular Cortex Neurons Projecting to the Lateral Hypothalamus in Anxiety-Related Behaviors and Social Observation." Master's thesis, 2020. http://hdl.handle.net/10316/92574.

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Dissertação de Mestrado em Biologia Celular e Molecular apresentada à Faculdade de Ciências e Tecnologia<br>A valência emocional é o valor subjetivo atribuído a estímulos sensoriais. O facto de a capacidade de avaliação da valência estar diminuída em pacientes com patologias de ansiedade sugere fortemente uma sobreposição entre os circuitos neuronais que codificam a ansiedade e a valência. O cortex insular, ou insula, é uma região crucial na codificação da valência no cérebro dos mamíferos, e a sua atividade está aumentada em pacientes com patologias de ansiedade e em indivíduos saudáveis dura
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Venkataraman, Archana. "Differential Protein Expression in the Insular Cortex and the Amygdala after Taste Memory Acquisition and Retrieval." Thesis, 2013. http://hdl.handle.net/1969.1/149589.

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Long-term memories turn labile with reactivation and undergo a re-stabilization process, termed reconsolidation, involving molecular changes that allow updating of an existing memory trace. Such molecular changes may involve the activation of kinases and expression of proteins related to the increase of synaptic plasticity and memory formation. A kinase reported to have a role in a variety of memory tasks is the extracellular signal-regulated kinase 1/2 (ERK1/2). The downstream activation of ERK targets other regulatory enzymes, transcription factors and cytoskeletal proteins, which allow stru
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Tuerke, Katharine. "The Role of Serotonin Availability in the Rat Insular Cortex on Conditioned Disgust and Conditioned Taste Avoidance." Thesis, 2013. http://hdl.handle.net/10214/5336.

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Although the neural mechanisms regulating vomiting are well understood, the neurobiology of nausea is not. Unlike conditioned taste avoidance (CTA), conditioned disgust (indicated by orofacial gaping reactions) is a model of nausea-induced behaviour in rats because it is selectively produced by emetic drugs and anti-emetics attenuate it. Treatments that reduce serotonin (5-HT) availability selectively interfere with conditioned gaping (Limebeer and Parker, 2000; 2003) and forebrain serotonin is critical for the production of disgust reactions (Grill and Norgren, 1978b; Limebeer et al., 2004).
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Shin, Yu Cin, and 施育欽. "The Examination on Mu-opioid Receptor on Insular Cortex in the Rats with Central Post-Stroke Pain (CPSP) Induced by Thalamic Hemorrhage." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/63478915175182174919.

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碩士<br>長庚大學<br>物理治療學系<br>102<br>Background: CPSP refers to the central pain from stroke. CPSP is attributed to a thalamic lesion, and may be associated with extrathalamic lesions. Recently evidences showed that insula cortex play an important role and involved the pain modulation of CPSP via its opioid receptors. However, it is unknown that the types of the opioid receptors on the insular cortex involve the re-looping of the central thermal disinhibition pathway to modulate the CPSP.. Method: Adult male Sprague–Dawley rats (250 g) following separate groups were examine, (1) Mu agonist (2) Mu an
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