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Journal articles on the topic 'Corydine'

Author: Grafiati

Published: 5 June 2025

Last updated: 26 June 2025

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1

Táborská, Eva, Milena Mikešová, František Věžník, and Jiří Slavík. "Alkaloids of the two Hypecoum L. species." Collection of Czechoslovak Chemical Communications 52, no. 2 (1987): 508–13. http://dx.doi.org/10.1135/cccc19870508.

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Alkaloids from Hypecoum procumbens L. and H. leptocarpum HOOK. F. et THOMS. were investigated. Protopine was the dominant alkaloid in both species. From H. procumbens chelerythrine and corydine were newly isolated in addition to the earlier detected alkaloids allocryptopine, sanguinarine, coptisine, and isocorydine. From H. leptocarpum allocryptopine, isocorydine and corydine were isolated for the first time, in addition to the earlier described alkaloids protopine, sanguinarine, chelerythrine and coptisine. Cryptopine was detected chromatographically. From the fraction of strongly polar alkaloids of both species magnoflorine, (-)-trans-N-methyl-stylopinium hydroxide, and in small amounts a new secoberbine alkaloid of oxohypecorinine structure, procumbine (I), and two further alkaloids of unsolved structure were isolated in the form of iodides.

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2

Singh, Deepika, and Prabir K. Chaudhuri. "(+) Corydine from the Stems of Tinospora cordifolia." Asian Journal of Chemistry 27, no. 4 (2015): 1567–68. http://dx.doi.org/10.14233/ajchem.2015.18509.

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3

Shafiee, Abbas, and Ata Jafarabadi. "Corydine and Norcorydine from the Roots ofChelidonium majus." Planta Medica 64, no. 05 (1998): 489. http://dx.doi.org/10.1055/s-2006-957498.

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4

Věžník, František, Irgash A. Israilov, Eva Táborská, and Jiří Slavík. "On alkaloids of three Papaver species from the section Scapiflora REICHB." Collection of Czechoslovak Chemical Communications 50, no. 8 (1985): 1745–52. http://dx.doi.org/10.1135/cccc19851745.

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The main alkaloid of the aerial part of P. croceum LEDEB. was nudaurine (I), isolated for the first time. In addition to amurine, known to be present in this species, oxysanguinarine (II) and corydine (IIIa) were also newly isolated and the presence of papaverrubine D demonstrated. In the fraction of tertiary bases from P.kerneri HAYEK allocryptopine and epialpinine (IV) were isolated as further alkaloids in addition to the already known alkaloids amurensine (the main alkaloid), amurensinine, amurine, alpinigenine, muramine, protopine, mecambridine, nudaurine, cryptopine and papaverrubines B, D, and G. In the fraction of quaternary bases the presence of traces of coptisine was detected, and in addition to alborine (alkaloid PO-5) cis-N-methyltetrahydropalmatinium hydroxide (V) was isolated for the first time in the form of iodide from P. kerneri. In P. tatricum (NYÁR.) EHREND. allocryptopine, epialpinine, and amurensinine were identified as the dominant alkaloids, while among the minor components protopine, amurensine, muramine, palmatine, coptisine, corytuberine (IIIb), N-methyltetrahydropalmatinium hydroxide, and N-methylamurensinium hydroxide could be demonstrated. Corydine (IIIa) and corytuberine (IIIb) represent the first two aporphine alkaloids found in the Scapiflora section.

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5

Chen, Chien-Kuang, Su-Chang Chen, Chung-Hsiung Chen, and Shoei-Sheng Lee. "Isoquinoline Alkaloids from the Leaves of Dehaasia Hainanensis." Natural Product Communications 2, no. 1 (2007): 1934578X0700200. http://dx.doi.org/10.1177/1934578x0700200115.

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This study was aimed at investigating the alkaloids present in the leaves of Dehaasia hainanensis. Thirteen isoquinolines were isolated and characterized. Of these, four aporphines [(+)-laurolitsine, (+)-corydine, (+)-laurotetanine and (+)-lindcarpine], two morphinans [(-)-sinoacutine and (-)-ocobotrine], four benzylisoquinolines [(+)-reticuline, (+)-roefractine, (+)-reticuline N-oxide, and O-methylarmepavine], and one bisbenzylisoquinoline [(-)-N,N'-dimethyllindoldhamine] are reported for the first time from Dehaasia species. The structures were elucidated by spectral analysis.

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6

Eric, Dade J. M., Coulibali Siomenan, Kouamé Bi Koffi François Prévost, et al. "A new natural indole and three aporphine alkaloids from Monodora bevipes Benth. (Annonaceae)." International Current Pharmaceutical Journal 6, no. 7 (2017): 40–43. http://dx.doi.org/10.3329/icpj.v6i7.34330.

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Four compounds were isolated from the leaves of Monodora brevipes Benth. (Annonaceae). Among them, one new natural indole named 5-formylindole (1) and three known aporphine alkaloids: (+)-roemeroline (2); (+)-corydine (3) and (+)-menispermine (4). They were isolated for the first time from this species. The structures of these compounds were established according to their spectral data (NMR, SM, IR and UV).Eric et al., International Current Pharmaceutical Journal, June 2017, 6(7): 40-43http://www.icpjonline.com/documents/Vol6Issue7/01.pdf

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7

O.J., Onoja, and Olawuni J.I. "DPPH Radical Scavenging Activity of Corydine Isolated from Tinospora cordifolia." African Journal of Pharmaceutical Sciences 3, no. 2 (2023): 68–78. http://dx.doi.org/10.51483/afjps.3.2.2023.68-78.

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8

OJOGBANE ONOJA, JOEL, та JULIUS IDOWU OLAWUNI. "β-SECRETASE INHIBITORY ACTIVITY OF CLERODANE DITERPENOIDS AND APORPHINOID ALKALOIDS AND INSIGHT FROM IN SILICO ANALYSES". AFRICAN JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT 16, № 3 (2024): 80–86. https://doi.org/10.59493/ajopred/2024.3.9.

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The β-secretase, which is a β-site amyloid precursor protein cleaving enzyme 1 (BACE1), starts the synthesis of toxic amyloid β (Aβ), which is a key early factor in the pathophysiology of Alzheimer’s disease (AD). No cure for AD so far which necessitate the search for new neurotherapeutic agents especially from natural products (NPs). Inhibiting BACE1 using NP’s inhibitors is considered a promising strategy. The study aims to evaluate the BACE 1 inhibitory potentials of clerodane diterpenoids and aporphinoid alkaloids from the stem of Tinospora cordifolia (Willd.) Miers ex Hook. F. & Thoms (Menispermaceae) and get Insight from in silico analyses using molecular docking and MM-GBSA. The enzyme assay was done in vitro using the UV-spectroscopic method. Molecular docking was carried out using Maestro software (Schrödinger). Ligands were docking with PDB ID: 3DV1 complex with NVP-ARV999. 8-hydroxycolumbin, a clerodane diterpenoid have the highest potential to inhibit the enzyme β-secretase (IC50 = 0.040±0.00 mg/mL, 58.58% inhibition) when compared to quercetin (IC50 = 0.055±0.00 mg/mL, 72.32% inhibition) at 0.1 mg/mL. Molecular docking demonstrated the presence of hydrogen bonding and π-π Interactions between ligands and enzyme active sites. N-formylanonaine has the best (ΔGbind) (MM-GBSA) (-28.64 kcal/mol) followed by corydine (-21.64 kcal/mol). N-formylanonaine, corydine and 8-hydroxycolumbin could be a template in the discovery of new neurotherapeutic agent in the management of AD due to their abilities to effectively bind to β-secretase protein residues

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9

Parvin, Mst Shamima, Jakub Chlebek, Anna Hošťálková, et al. "Interactions of Isoquinoline Alkaloids with Transition Metals Iron and Copper." Molecules 27, no. 19 (2022): 6429. http://dx.doi.org/10.3390/molecules27196429.

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Data on alkaloid interactions with the physiologically important transition metals, iron and copper, are mostly lacking in the literature. However, these interactions can have important consequences in the treatment of both Alzheimer’s disease and cancer. As isoquinoline alkaloids include galanthamine, an approved drug for Alzheimer’s disease, as well as some potentially useful compounds with cytostatic potential, 28 members from this category of alkaloids were selected for a complex screening of interactions with iron and copper at four pathophysiologically relevant pH and in non-buffered conditions (dimethyl sulfoxide) by spectrophotometric methods in vitro. With the exception of the salts, all the alkaloids were able to chelate ferrous and ferric ions in non-buffered conditions, but only five of them (galanthine, glaucine, corydine, corydaline and tetrahydropalmatine) evoked some significant chelation at pH 7.5 and only the first two were also active at pH 6.8. By contrast, none of the tested alkaloids chelated cuprous or cupric ions. All the alkaloids, with the exception of the protopines, significantly reduced the ferric and cupric ions, with stronger effects on the latter. These effects were mostly dependent on the number of free aromatic hydroxyls, but not other hydroxyl groups. The most potent reductant was boldine. As most of the alkaloids chelated and reduced the ferric ions, additional experimental studies are needed to elucidate the biological relevance of these results, as chelation is expected to block reactive oxygen species formation, while reduction could have the opposite effect.

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10

Slavík, Jiří, and Leonora Slavíková. "Alkaloids from Papaver albiflorum PACZ. subsp. albiflorum and P. cf. stevenianum A. D. Mikheev." Collection of Czechoslovak Chemical Communications 55, no. 7 (1990): 1812–16. http://dx.doi.org/10.1135/cccc19901812.

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Papaver albiflorum PACZ. subsp. albiflorum (tetraploid, 2n = 28; total alkaloid content 0.001%) afforded corytuberine, protopine and allocryptopine as dominant alkaloids; in addition, small amounts of macambrine, thebaine, scoulerine, rhoeadine, papaverrubines D, C, A and E, berberine and coptisine were detected. Papaver cf. stevenianum A. D. MIKHEEV (hexaploid, 2n = 42; total alkaloid content 0.066% and 0.015%, respectively) gave berberine as the principal alkaloid (0.065% and 0.013, respectively) which was responsible for the yellow colour of latex. Corytuberine, allocryptopine, protopine and isocorydine were isolated as minor alkaloids and small amounts of corydine, mecambrine, thebaine, scoulerine, papaverrubines D, C, A and E, coptisine, cis-N-methylcanadinium hydroxide and N-methylthebainium hydroxide were detected. Alkaloid PHC 1, isolated recently as minor constituent from Papaver rhoeas var. chelidonioides O. KUNTZE, has been shown to be identical with isorhoeagenine.

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11

Slavíková, Leonora, Jiří Slavík, and Ladislav Dolejš. "Quaternary alkaloids from Glaucium oxylobum BOISS. et BUSHE." Collection of Czechoslovak Chemical Communications 50, no. 4 (1985): 854–60. http://dx.doi.org/10.1135/cccc19850854.

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From the fraction of quaternary alkaloids of the aerial part of Glaucium oxylobum BOISS. et BUSHE (-)-trans-N-rnethylcanadinium iodide was isolated as the main alkaloid after conversion to iodides, and, in a smaller amount, (+)-N-methylcorydinium iodide, detected for the first time in Papaveraceae, further (-)-trans-N-methylstylopinium iodide, magnoflorine iodide and a new quaternary alkaloid, N-methyldomesticinium iodide, isolated for the first time as a natural substance. In the roots, magnoflorine iodide accompanied by (+)-N-methylcorydinium iodide represented the main component of the quaternary fraction. From both plant parts corytuberine was also isolated for the first time. In the tertiary fraction of alkaloids (+)-corydine, protopine and allocryptopine were the major components, accompanied by smaller amounts of sanguinarine, chelerythrine, chelirubine, domesticine, isoboldine and scoulerine. In the fraction of quaternary protoberberines coptisine, berberine and traces of corysamine were detected.

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12

Táborská, Eva, Jiří Dostál, Hana Bochořáková, and František Věžník. "Alkaloids of Papaver argemone L. and Papaver pavoninum FISCH. et MEY. From the Argemonorhoeades FEDDE section." Collection of Czechoslovak Chemical Communications 53, no. 8 (1988): 1845–50. http://dx.doi.org/10.1135/cccc19881845.

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Papaver argemone L. and Papaver pavoninum FISCH. et MEY. species of the Argemonorhoeades FEDDE (Papaveraceae) section were studied. A very low content of alkaloids was found in both species (less than 0·05%). P. argemone contains corytuberine and its quaternary N-methyl derivative magnoflorine as the dominant bases. As minor constituents were isolated: protopine, isocorydine, scoulerine, and alkaloids PAR 1, PAR 2, PAR 3. Chromatographic analysis detected allocryptopine, cryptopine, coptisine and traces of rhoeadine, papaverrubines C, D and E, and more than 6 unidentified bases. P. pavoninum gave N2-methyl-1,2,3,4-tetrahydro-β-carboline as the dominant alkaloid, along with minor amounts of the tertiary bases protopine, allocryptopine, corydine, isocorydine and corytuberine. Of quaternary bases, coptisine, magnoflorine and an unidentified alkaloid PP 1 were isolated. The presence of many other, considerably labile bases has been proven in both species.

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13

Táborská, Eva, Hana Bochořáková, František Věžník, Jiří Slavík, and Ladislav Dolejš. "Alkaloids from Papaver atlanticum BALL and Papaver glaucum BOISS. et HAUSKN." Collection of Czechoslovak Chemical Communications 51, no. 10 (1986): 2232–39. http://dx.doi.org/10.1135/cccc19862232.

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In addition to the alkaloids previously found in the aerial part of P. atlanticum BALL, viz. protopine, rhoeadine (predominant constituents), rhoeagenine, stylopine, cryptopine, sanguinarine, magnoflorine and papaverrubines A, B, E and D, we have now isolated the tertiary bases isothebaine, scoulerine, corytuberine and a new quaternary alkaloid 13β-hydroxy-N-methylstylopinium hydroxide (I). The presence of papaverrubine B and muramine was also detected (TLC). The contents of the bases in the roots of P. atlanticum were found similar to those in the aerial part. Magnoflorine was isolated from the roots in a considerable yield. The dominant alkaloids isolated from P. glaucum BOISS. et HAUSKN. were glaudine and glaucamine; they were accompanied by protopine, papaverrubine B and traces of sanguinarine, coptisine and papaverrubine C. Magnoflorine and corytuberine have been isolated from this species for the first time and the presence of allocryptopine, cryptopine, corydine, isocorydine and papaverrubines D and H has been demonstrated.

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14

KONDA, Yoshikazu, Yoshihiro IMAI, Hiroshi HOJO, Takeshi ENDO, and Shigeo NOZOE. "Suppression of tumor cell growth and mitogen response by aporphine alkaloids, dicentrine, glaucine, corydine, and apomorphine." Journal of Pharmacobio-Dynamics 13, no. 7 (1990): 426–31. http://dx.doi.org/10.1248/bpb1978.13.426.

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15

Slavík, Jiří, and Leonora Slavíková. "Alkaloids from Papaver bracteatum LINDL." Collection of Czechoslovak Chemical Communications 50, no. 5 (1985): 1216–26. http://dx.doi.org/10.1135/cccc19851216.

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N-Methylthebainium (as iodide) and corytuberine were isolated from the roots and green aerial parts of Papaver bracteatum LINDL., thebaine race Halle III, as significant alkaloids in addition to the predominant alkaloid thebaine (0.61 and 0.23% respectively), as well as the minor alkaloids isothebaine, scoulerine, protopine, epialpinine (O-methylalpinigenine), N-methylisothebainium (as iodide), isoboldine, corydine, rhoeadine, magnoflorine, a mixture of coptisine and palmatine and a new alkaloid PB 1 C18H19NO4. Bracteoline and papaverrubines G, E, D and C were detected chromatographically. From the ripe capsules of the race Halle III N-methylthebainium (as perchlorate), corytuberine and a mixture of coptisine and palmatine were isolated in addition to thebaine (0.67%). From the ripe capsules of P. bracteatum, population Demavend (Iran), thebaine (0.56%), epialpinine, alpinigenine, corytuberine, N-methylthebainium (as iodide) and a mixture of coptisine and palmatine were isolated and the presence of papaverrubines G, D and C was detected. In the latex of flowering plants salutaridine was also detected. Fourteen of the mentioned alkaloids were detected in the species P. bracteatum for the first time.

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16

Slavík, Jiří, and Leonora Slavíková. "On alkaloids from the aerial parts of three Eschscholtzia species." Collection of Czechoslovak Chemical Communications 51, no. 8 (1986): 1743–51. http://dx.doi.org/10.1135/cccc19861743.

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In the aerial parts of Eschscholtzia californica CHAM., E. douglasii (HOOK. etARN.) WALP. and E. glauca GREENE the main alkaloidal component is the quaternary base californidine. Eschscholtzine, allocryptopine, and protopine belong among the dominant tertiary alkaloids, which are accompanied by a small amount of N-methyllaurotetanine and the quaternary benzophenanthridines (sanguinarine, chelerythrine, chelirubine, chelilutine, and macarpine). The pavinane alkaloids isonorargemonine, caryachine, norargemonine, and bisnorargemonine and the aporphine alkaloids corydine and isocorydine were isolated from the aerial part of the E. douglasii species for the first time. These alkaloids were also detected in E. californica and E. glauca. Corytuberine was also isolated from all three species. From the fraction of Quaternary alkaloids after conversion to iodides, in addition to californidine, escholamidine iodide was isolated from E. californica and E. douglasii species. From E. douglasii N-methylcaryachinium iodide and from E. glauca magnoflorine iodide were also isolated. The presence of a small amount of the mentioned quaternary alkaloids, as well as traces of escholamine were also detectable in all three species.

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17

Slavík, Jiří, Leonora Slavíková, and Jitka Bochořáková. "Alkaloids from Papaver rhoeas var. chelidonioides O. KUNTZE, P. confine JORD., and P. dubium L." Collection of Czechoslovak Chemical Communications 54, no. 4 (1989): 1118–25. http://dx.doi.org/10.1135/cccc19891118.

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Papaver rhoeas var. chelidonioides O. KUNTZE (diploid, 2n = 14) contains rhoeadine (0.027%) and coptisine (0.004%) as the dominant alkaloids, the latter being the yellow principle of the latex. As minor constituents were isolated protopine, papaverrubine A, rhoeagenine, (-)-stylopine, an unidentified alkaloid PCH 1 (m.p. 205 °C), 2-methyl-1,2,3,4-tetrahydro-β-carboline and (-)-trans-N-methylstylopinium hydroxide. Chromatographic analysis detected isorhoeadine, allocryptopine, cryptopine, papaverrubine C, D and E, scoulerine, isoboldine, berberine, corysamine, magnoflorine and corytuberine. P. confine JORD. (tetraploid, 2n = 28) was found to display a very low alkaloid content (0.003%) and afforded corytuberine and berberine as principal alkaloids, along with minor amounts of protopine rhoeadine, scoulerine and cryptopine. Chromatography identified isocorydine, corydine, allocryptopine, aporheine, stylopine, sinactine, thebaine, mecambrine, papaverrubines A, E, C and D, coptisine and corysamine. The tertiary alkaloid fraction from ripe capsules of P. dubium L. (hexaploid, 2n = 42; 0.24% of alkaloids) of domestic origin afforded (+)-roemerine (aporheine) as the main constituent (87% of total bases); mecambrine, protopine, rhoeadine and papaverrubines D and C (traces of A and E) were detected. From strongly polar bases N-methylaporheinium hydroxide (as iodide) was isolated and corytuberine detected.

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18

Husna Hasnan, Muhammad Hafiz, Yasodha Sivasothy, Kooi Yeong Khaw, et al. "N-Methyl Costaricine and Costaricine, Two Potent Butyrylcholinesterase Inhibitors from Alseodaphne pendulifolia Gamb." International Journal of Molecular Sciences 24, no. 13 (2023): 10699. http://dx.doi.org/10.3390/ijms241310699.

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Studies have been conducted over the last decade to identify secondary metabolites from plants, in particular those from the class of alkaloids, for the development of new anti-Alzheimer’s disease (AD) drugs. The genus Alseodaphne, comprising a wide range of alkaloids, is a promising source for the discovery of new cholinesterase inhibitors, the first-line treatment for AD. With regard to this, a phytochemical investigation of the dichloromethane extract of the bark of A. pendulifolia Gamb. was conducted. Repeated column chromatography and preparative thin-layer chromatography led to the isolation of a new bisbenzylisoquinoline alkaloid, N-methyl costaricine (1), together with costaricine (2), hernagine (3), N-methyl hernagine (4), corydine (5), and oxohernagine (6). Their structures were elucidated by the 1D- and 2D-NMR techniques and LCMS-IT-TOF analysis. Compounds 1 and 2 were more-potent BChE inhibitors than galantamine with IC50 values of 3.51 ± 0.80 µM and 2.90 ± 0.56 µM, respectively. The Lineweaver–Burk plots of compounds 1 and 2 indicated they were mixed-mode inhibitors. Compounds 1 and 2 have the potential to be employed as lead compounds for the development of new drugs or medicinal supplements to treat AD.

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19

Marpaung, Jon Kenedy, and Melisa Rekayana Tambuan. "AKTIVITAS PENGHAMBATAN ENZIM PROTEASE 6LU7 VIRUS SARS-COV-2 OLEH SENYAWA ALKALOID DARI ATTARASA (Litsea cubeba (Lour.)Pers.) SECARA IN-SILICO." JURNAL FARMANESIA 7, no. 2 (2020): 1–8. http://dx.doi.org/10.51544/jf.v7i2.2769.

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Attarasa (Litsea cubeba (Lour.) Pers.) is a mountain plant known as "Mountain pepper" or "Mountain Pepper". This plant contains alkaloids, such as Oblongine; Actinodaphine; Isoboldine; Cassameridine; Coclaurine; Corydine; Corytuberine; Dicentrine; Laurotetanine; Lindcarpine; Isocorydine; Isodomesticine; Juziphine; N-Methylcoclaurine; N-Methyllaurotetanine; N-Methyllindcarpine; Norcorydine; Norisoboldine; Norisocorydine; Xanthoplanine. Alkaloids in Attarasa (Litsea cubeba (Lour.) Pers.) have properties such as antimicrobials. This study aimed to determine the inhibition of the protease enzyme 6LU7 of the SARS-CoV-2 virus by an alkaloid compound from Attarasa (Litsea cubeba (Lour.) Pers.) by using the in silico tethering method. The in silico tethering process is carried out using the PLANTS program and visualized using the MOE2008 program. The protease enzyme was downloaded via the Protein Data Bank (PDB) with the code 6LU7. Two- and three-dimensional models are generated using the Marvin Sketch program. The resulting docking value is evaluated as a result of the docking process. The results of this study indicate that the binding of alkaloid compounds from Attarasa (Litsea cubeba (Lour.) Pers.) to 6LU7 expression gave valid results in silico. The compound N-Methylcoclaurine, Coclaurine, and Laurotetanin inhibited the protease enzyme 6LU7 with the best score close to the comparative value of Lopinavir and Remdesivir and produced 7 amino acid residues that were bound to each other, namely val_114, val_13, leu_115, phe_150, gly_140, val_140, and ser_147.

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20

Koirala, Pramila, and Bimala Singh. "Dicentra scandens (D.Don) Walp. - A Potential Source of Antimicrobial Agent." International Journal of Toxicological and Pharmacological Research 9, no. 1 (2017): 6–14. https://doi.org/10.5281/zenodo.12730297.

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<em>Dicentra scandens</em> (D.Don) Walp. locally called as ‘<em>Jogi Lahara</em>’ belongs to the Family <em>Fumariaceae</em> and is used in traditional medicine in Sikkim, a North Eastern state of India. The present study investigated the antimicrobial properties of aqueous and methanol extracts of <em>Dicentra scandens</em> (D.Don) Walp. against some test Gram negative and Gram positive bacteria. Using agar well diffusion method, aqueous and methanol extracts of roots of <em>Dicentra scandens </em>were tested against <em>Escherichia</em><em> coli</em> (MTCC 1089), <em>Klebsiella pneumoniae</em> (MTCC 3384)<em>,</em> <em>Pseudomonas aeruginosa</em> (MTCC 1034)<em>, Proteus vulgaris</em> (MTCC 742)<em>,</em><em> Salmonella typhi </em>(MTCC 733)<em>, Shigella flexneri </em>(MTCC 1457)<em>, Vibrio cholerae</em> O139(MTCC 3906)<em>, Bacillus cereus</em> (MTCC 6840) and<em> Staphylococcus aureus </em>(MTCC 7443). Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) were also evaluated. Promising antimicrobial activity was exhibited by methanol extract of <em>Dicentra scandens</em>. The methanol extract was further characterized by Gas Chromatography-Mass Spectrometry (GC-MS) analysis. The GC-MS analysis revealed 29 compounds and the major compounds detected were Protopine (53.78%) and Corydine (18.20%). Thus, the alkaloids are predominant phytoconstituents of the extract and could be attributed to its antimicrobial activity. The results of the present study indicate that, <em>Dicentra scandens</em> can be a source of potential antimicrobial agent and can be explored further for its therapeutic use.

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21

Wiseman, Timothy Peter. "Locating Corydon." Hermes 151, no. 3 (2023): 334–45. http://dx.doi.org/10.25162/hermes-2023-0027.

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22

Harrison, S. J. "The lark ascending: Corydon, Corydon (Vergil, Ecl. 7.70)." Classical Quarterly 48, no. 1 (1998): 310–11. http://dx.doi.org/10.1093/cq/48.1.310.

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23

Ribár, B., D. Lazar, P. Radivojević, P. Engel, O. Gašić, and I. Kanyó. "Structure of corydaline." Acta Crystallographica Section C Crystal Structure Communications 48, no. 10 (1992): 1864–66. http://dx.doi.org/10.1107/s0108270192001951.

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24

BOHN, HORST. "The spine armament of the legs as an important means for the characterisation of the genera of Corydiinae and their relationships (Blattodea, Corydiidae)." Zootaxa 5482, no. 1 (2024): 1–79. http://dx.doi.org/10.11646/zootaxa.5482.1.1.

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The Palaearctic species of Corydiinae having no apical spine on the femora of the frontleg (48 species distributed to the genera Heterogamisca, Heterogamodes, Hemelytroblatta, Leiopteroblatta, Mononychoblatta, Nymphrytria, Psammoblatta) were studied in mainly three characters: tibia armament, features of the right phallomere, and distribution of bristles on the subgenital plate. The results suggest considerable changes in the classification with now 5 genera and several subgenera: (1) Heterogamodes with subgenera Heterogamodes, Heterogamisca, and Atuberculoblatta subgen. nov.; (2) Hemelytroblatta with subgenera Hemelytroblatta and Mollidentoblatta subgen. nov.; (3) Nymphrytria with subgenera Nymphrytria, Mononychoblatta, and Leiopteroblatta; (4) Psammoblatta; and (5) Fissidentoblatta gen. nov. The presumed relationships between the genera (1)–(3) are shown in a cladogram (Fig. 23). Four species of the subgenus Heterogamisca are described as new: H. longipilosa, H. sulcata, H. brevipennis, and H. pallens; a fifth species, H. jeffreyana, member of the Maltese fauna, had recently been described (Bohn & Sciberras 2021). A determination key allows the identification of the males of the genus Heterogamodes and its subgenera. All genera of Corydiinae, the following in addition to the already mentioned: Anisogamia, Arenivaga, Eremoblatta, Ergaula, Eucorydia, Eupolyphaga, Homoeogamia, Polyphaga, Polyphagina, and Therea, were studied in tibia armament, distribution of tricholiths on the cerci, wing structures and some other characters. The study revealed three groups of genera: The Therea-group with the Nearctic genera Homoeogamia, Ergaula, Eucorydia, and Therea; the Arenivaga-group with the Nearctic genera Arenivaga and Eremoblatta and the Palaearctic genus Polyphagina; and the Polyphaga-group containing the genera Anisogamia, Eupolyphaga, Polyphaga and all genera already mentioned in the first paragraph. The Therea-group most likely represents the most basal group of the Corydiinae, but appears as already split into two branches, with the Nearctic Homoeogamia on the one branch finally terminating in the Arenivaga-group, and the three other Old World genera on the other branch terminating in the Polyphaga-group (Fig. 24). The proposed phylogenetic relationships can only be seen as tentative and need proof on both fields of methods: on the morphological side the complex structures of the phallomeres still offer a rich arsenal of different structures hitherto certainly only partly used; on the side of the molecular methods a large extension of the number of genera to be studied is necessary including all known genera of Corydiinae. The unition of Princis’ Polyphagidae and Homoeogamiidae to one subfamily, Corydiinae, by Grandcolas 1994a appears justified, but with the exclusion of Cryptocercus. The genera Austropolyphaga, and Polyphagoides, later added by Roth (2003), have to be removed from Corydiinae: shape and size of the postclypeal shield exclude their belonging to this subfamily and there are no relevant characters known which the two genera share with Corydiinae. The same applies to the presumably erroneous addition of Hypercompsa to Corydiinae by Roth. Tivia inconspicua (Tiviinae) differs in several important characters from the other Tivia species. It is placed in a newly errected genus: Tiviella gen. nov..

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25

Weingardt, Richard G. "Corydon Tyler Purdy." Leadership and Management in Engineering 10, no. 3 (2010): 124–30. http://dx.doi.org/10.1061/(asce)lm.1943-5630.0000067.

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26

Rueffer, Martina, Wolfgang Bauer, and Meinhart H. Zenk. "The formation of corydaline and related alkaloids in Corydalis cava in vivo and in vitro." Canadian Journal of Chemistry 72, no. 1 (1994): 170–75. http://dx.doi.org/10.1139/v94-026.

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The biosynthesis of corydaline and thalictricavine has been investigated by application of [8-3H]-labelled palmatine and berberine to Corydalis cava bulb tissue. In both cases, high incorporation into the respective (14R,13S)corydaline and -thalictricavine was observed. (S)-[14-3H, 8-14C]Scoulerine was also transferred into corydaline with all of the tritium being lost, indicating that a redox reaction had taken place in the transition of the (14S) to the (14R) product. A partly enriched protein fraction catalyzed the reduction of both protoberberine precursors to the 7,8-dihydro intermediate, which was subsequently methylated at C-13 at the expense of S-adenosylmethionine (SAM) and reduced at C-14 by a B-type reaction with NADPH as reductant. The identity of the product was unequivocally established by NMR, MS, and CD measurements. This biosynthetic route is in full agreement with previously published predictions based on in vivo experiments.

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27

RIBAR, B., D. LAZAR, P. RADIVOJEVIC, P. ENGEL, O. GASIC, and I. KANYO. "ChemInform Abstract: Structure of Corydaline." ChemInform 24, no. 5 (2010): no. http://dx.doi.org/10.1002/chin.199305278.

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28

Adeniran, Olawole Yakubu. "Identification of Novel Plant-derived Inhibitors of the EGFR Kinase Domain Using vHTS, QSAR and Molecular Docking Approaches." Asian Journal of Biochemistry, Genetics and Molecular Biology 16, no. 7 (2024): 69–84. http://dx.doi.org/10.9734/ajbgmb/2024/v16i7392.

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The epidermal growth factor receptor (EGFR) protein tyrosine kinase (PTK) is a crucial target in the pursuit of anti-tumor drug discovery. This study investigates 305 phytochemicals from five known anticancer plants (Anacardium occidentale, Annona muricata, Spondias mombin, Ocimum gratisimum, and Zingiber officinale) for their potential as EGFR kinase domain inhibitors. Through Virtual High Throughput Screening (vHTS), lead compounds were identified and subjected to ADMET filtering. A Quantitative Structure-Activity Relationship (QSAR) model was developed using bioassay data from the ChEMBL database, exhibiting strong statistical robustness and external validation. Molecular docking studies revealed interactions of lead compounds with critical residues within the EGFR ATP kinase domain. Actinidine, berberine, and corydaline demonstrated adherence to Lipinski's rule of five, indicating drug-likeness. Notably, actinidine forms hydrophobic interactions with Phe-856, while berberine establishes hydrogen bonds with Asp-855. Corydaline engages in extensive hydrophobic and hydrogen bond interactions within the ATP pocket of the EGFR kinase domain. These findings underscore the potential of actinidine, berberine, and corydaline as EGFR kinase domain inhibitors, supported by a robust QSAR model, marking progress in the search for novel anticancer agents targeting EGFR inhibition.

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29

Qiu, Lu, Yang-Li Che, and Zong-Qing Wang. "A taxonomic study of Eupolyphaga Chopard, 1929 (Blattodea: Corydiidae: Corydiinae)." Zootaxa 4506, no. 1 (2018): 1–68. https://doi.org/10.11646/zootaxa.4506.1.1.

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30

Slavík, Jiří, and Leonora Slavíková. "Alkaloids from Corydalis nobilis (L.) PERS. and C. intermedia (L.) MÉRAT." Collection of Czechoslovak Chemical Communications 54, no. 7 (1989): 2009–20. http://dx.doi.org/10.1135/cccc19892009.

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Rhizomes of Corydalis nobilis (L.) PERS. (3% of alkaloids) contain (+)-tetrahydropalmatine, (+)-bicuculline and (+)-corytuberine as the main constituents of the tertiary alkaloid fraction. Protopine, (+)-corypalmine and (+)-stylopine, which also belong to the dominant alkaloids, were isolated in lesser amounts. As minor alkaloids were isolated (±)-tetrahydropalmatine, (+)-corydaline, allocryptopine, cryptopine, (-)-scoulerine, (+)-adlumidine, (+)-sinactine, (±)-corlumine, isoboldine, (+)-corybulbine, (±)-stylopine and (-)-isocorypalmine. The fraction of quaternary protoberberine alkaloids afforded coptisine dehydrocorydaline, palmatine, corysamine jatrorrhizine and cis-N-methylstylopinium hydroxide. Aobamidine (Z-adlumidiceine enol lactone), isolated as the principal alkaloid of aerial parts (0.3% of alkaloids), is obviously an artifact arising from bicuculline N-metho salt during the isolation process. Further dominant alkaloids of the tertiary fraction were adlumidine, bicuculline, protopine, (±)-tetrahydropalmatine and (±)-corlumine; as minor alkaloids were isolated corytuberine, scoulerine, corypalmine, cryptopine, isocorypalmine, corybulbine, (+)-corydalizine, and unidentified alkaloids CN 1 (C23H25NO5, m.p. 211 °C) and CN 2 (m.p. 261 °C). Quaternary protoberberine fraction afforded coptisine and palmatine. Nineteen of the mentioned alkaloids were isolated from this species for the first time. Tubers of C. intermedia (L.) MÉRAT (0.70% of alkaloids) afforded protopine, tetrahydropalmatine and corydaline as the main alkaloids and allocryptopine, canadine stylopine, palmatine, dehydrocorydaline, berberine, coptisine as minor alkaloids, together with traces of bicuculline and magnoflorine. Dominant alkaloids of the aerial part (0.73% of alkaloids) were bicuculline, bulbocapnine, protopine, stylopine and an unidentified phenolic base, m.p. 258 °C. Isoboldine, scoulerine, allocryptopine, corydaline, canadine, coptisine, palmatine and berberine were identified as the minor alkaloids.

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31

Qiu, Lu, Yan-Li Che, and Zong-Qing Wang. "Contributions to some Corydiinae genera (Blattodea: Corydioidea: Corydiidae) from China." Journal of Natural History 52, no. 21-22 (2018): 1433–61. https://doi.org/10.1080/00222933.2018.1463406.

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Qiu, Lu, Che, Yan-Li, Wang, Zong-Qing (2018): Contributions to some Corydiinae genera (Blattodea: Corydioidea: Corydiidae) from China. Journal of Natural History (J. Nat. Hist.) 52 (21-22): 1433-1461, DOI: 10.1080/00222933.2018.1463406, URL: http://dx.doi.org/10.1080/00222933.2018.1463406

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32

Qiu, Lu, Yanli Che, and Zongqing Wang. "Revision of Eucorydia Hebard, 1929 from China, with notes on the genus and species worldwide (Blattodea, Corydioidea, Corydiidae)." ZooKeys 709 (October 18, 2017): 17–56. https://doi.org/10.3897/zookeys.709.14755.

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The cockroach genus Eucorydia from China is revised. Five new species are described and illustrated: Eucorydia linglong sp. n., Eucorydia pilosa sp. n., Eucorydia splendida sp. n., Eucorydia guilinensis sp. n., and Eucorydia tangi sp. n.. Corydia purpuralis Kirby, 1903 and Eucorydia paucipilosa Woo, Guo & Feng, 1986 are confirmed to be junior synonyms of Eucorydia dasytoides (Walker, 1868). Eucorydia hilaris (Kirby, 1903) is newly recorded from China. This genus and currently known species from around the world are discussed. The status of Eucorydia maxwelli (Hanitsch, 1915) is revived. Corydia plagiata Walker, 1868 is confirmed to be a junior synonym of Eucorydia ornata (Saussure, 1864). A checklist, key, and photographs of members of this genus are provided.

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33

Bohn, Horst. "The spine armament of the legs as an important means for the characterisation of the genera of Corydiinae and their relationships (Blattodea, Corydiidae)." Zootaxa 5482, no. 1 (2024): 1–79. https://doi.org/10.11646/zootaxa.5482.1.1.

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Bohn, Horst (2024): The spine armament of the legs as an important means for the characterisation of the genera of Corydiinae and their relationships (Blattodea, Corydiidae). Zootaxa 5482 (1): 1-79, DOI: 10.11646/zootaxa.5482.1.1, URL: http://dx.doi.org/10.11646/zootaxa.5482.1.1

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34

Tang, Hsin-Chieh, and Calvin Yu-Chian Chen. "Drug Design of Cyclin-Dependent Kinase 2 Inhibitor for Melanoma from Traditional Chinese Medicine." BioMed Research International 2014 (2014): 1–17. http://dx.doi.org/10.1155/2014/798742.

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One has found an important cell cycle controller. This guard can decide the cell cycle toward proliferation or quiescence. Cyclin-dependent kinase 2 (CDK2) is a unique target among the CDK family in melanoma therapy. We attempted to find out TCM compounds from TCM Database@Taiwan that have the ability to inhibit the activity of CDK2 by systems biology. We selected Tetrahydropalmatine, Reserpiline, and (+)-Corydaline as the candidates by docking and screening results for further survey. We utilized support vector machine (SVM), multiple linear regression (MLR) models and Bayesian network for validation of predicted activity. By overall analysis of docking results, predicted activity, and molecular dynamics (MD) simulation, we could conclude that Tetrahydropalmatine, Reserpiline, and (+)-Corydaline had better binding affinity than the control. All of them had the ability to inhibit the activity of CDK2 and might have the opportunity to be applied in melanoma therapy.

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35

Qiu, Lu, Zong-Qing Wang, and Yan-Li Che. "Minpolyphaga inexpectata, a new genus and species of Polyphagini (Blattodea: Corydiidae: Corydiinae) from southeast China." Acta Entomologica Musei Nationalis Pragae 59, no. 2 (2019): 513–18. https://doi.org/10.2478/aemnp-2019-0042.

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Qiu, Lu, Wang, Zong-Qing, Che, Yan-Li (2019): Minpolyphaga inexpectata, a new genus and species of Polyphagini (Blattodea: Corydiidae: Corydiinae) from southeast China. Acta Entomologica Musei Nationalis Pragae 59 (2): 513-518, DOI: 10.2478/aemnp-2019-0042, URL: http://dx.doi.org/10.2478/aemnp-2019-0042

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36

Jung, Ji Won, Mi Ran Choi, Yong Sam Kwon, Jin Seok Jeong, Miwon Son, and Hee Eun Kang. "Gender differences in corydaline pharmacokinetics in rats." Xenobiotica 45, no. 5 (2014): 456–63. http://dx.doi.org/10.3109/00498254.2014.988772.

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37

Codazzi, Paola. "Alain Goulet, Les “Corydon” d’André Gide." Studi Francesi, no. 175 (LIX | I) (April 1, 2015): 189. http://dx.doi.org/10.4000/studifrancesi.590.

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38

Eckerman, Chris. "THYRSIS’ ARCADIAN SHEPHERDS IN VIRGIL'S SEVENTH ECLOGUE." Classical Quarterly 65, no. 2 (2015): 669–72. http://dx.doi.org/10.1017/s0009838815000142.

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In Virgil's seventh Eclogue, Meliboeus relates a singing contest that Corydon and Thyrsis undertook. Upon beginning their songs, Corydon invokes the Libethrian nymphs (21), and Thyrsis invokes ‘Arcadian shepherds’ (25–6). Scholars have previously interpreted Thyrsis’ Arcadian shepherds as people, but here I suggest that they should be interpreted as divinities. In support of this assertion, I rely on the expectations of the capping style (which requires that Thyrsis ‘cap’ Corydon's invocation of Libethrian nymphs), Virgil's description of the setting and the characters present, an epigram by Erucius (an intertext for this poem), the Greek and Roman literary tradition that developed especially in relation to gods associated with Arcadia, and Thyrsis’ quatrains, which can be profitably interpreted if we assume that Arcadian gods have heard Thyrsis' prayer and are now inspiring his song.

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39

Spisak, April. "Corydon & the Island of Monsters (review)." Bulletin of the Center for Children's Books 59, no. 7 (2006): 309. http://dx.doi.org/10.1353/bcc.2006.0195.

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40

Seropian, Armen, Eka Arsenashvili, Natalia Bulbulashvili, et al. "The first DNA-assisted record of Hemelytroblatta livida (Blattodea: Corydiidae) from Georgia with notes on Corydiinae species composition in the Caucasus." Caucasiana 2 (May 2, 2023): 71–75. http://dx.doi.org/10.3897/caucasiana.2.e103189.

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The fossorial sand cockroach Hemelytroblatta livida (Brunner von Wattenwyl, 1865) is reported from Georgia for the first time, with a commentary on the species composition of the Corydiinae Saussure, 1864 subfamily in the Caucasus. Collection data, pictures of the male and female, and DNA barcodes are also provided. Furthermore, information on Polyphaga aegyptiaca (Linnaeus, 1758) is provided, along with images of the male, female, and juvenile.

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41

Seropian, Armen, Eka Arsenashvili, Natalia Bulbulashvili, et al. "The first DNA-assisted record of Hemelytroblatta livida (Blattodea: Corydiidae) from Georgia with notes on Corydiinae species composition in the Caucasus." Caucasiana 2 (May 2, 2023): 71–75. https://doi.org/10.3897/caucasiana.2.e103189.

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The fossorial sand cockroach Hemelytroblatta livida (Brunner von Wattenwyl, 1865) is reported from Georgia for the first time, with a commentary on the species composition of the Corydiinae Saussure, 1864 subfamily in the Caucasus. Collection data, pictures of the male and female, and DNA barcodes are also provided. Furthermore, information on Polyphaga aegyptiaca (Linnaeus, 1758) is provided, along with images of the male, female, and juvenile.

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42

Wu, Lehao, Weiyue Zhang, Xin Qiu, et al. "Identification of Alkaloids from Corydalis yanhusuo W. T. Wang as Dopamine D1 Receptor Antagonists by Using CRE-Luciferase Reporter Gene Assay." Molecules 23, no. 10 (2018): 2585. http://dx.doi.org/10.3390/molecules23102585.

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Corydalis yanhusuo W. T. Wang (C. yanhusuo) has been traditionally used for drug addiction and pain relief in China. In our previous study, we showed that the extract of C. yanhusuo blocks dopamine receptors, demonstrating that its pharmacological activities are mostly due to the antagonistic effects of some of its components at dopamine receptors. As part of our ongoing project on C. yanhusuo, the aim of the present study is to establish a high-throughput and low-cost screening assay system and test the abilities of the isolated alkaloids from C. yanhusuo to inhibit dopamine-induced dopamine D1 receptor activity. By using our established cyclic adenosine monophosphate (cAMP)-response element (CRE)-luciferase reporter gene assay system, we identified eight alkaloids from C. yanhusuo with D1 receptor antagonistic activities. We next validated the activities of these compounds using fluorometric imaging plate reader (FLIPR) assay by measuring the intracellular Ca2+ change. Six out of eight compounds, including tetrahydropalmatine, corydaline, 13-methyldehydrocorydalmine, dehydrocorybubine, dehydrocorydaline, and columbamine, can be confirmed for their inhibitory activities. The dopamine-receptor-antagonistic effects of four compounds, including 13-methyldehydrocorydalmine, dehydrocorydaline, columbamine, and corydaline, are reported for the first time. The present study provides an important pharmacological basis to support the traditional use of C. yanhusuo in China.

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43

Hawcroft, Michael. "Gide's Corydon, ‘mise en abyme’, and Autobiographical Fiction." Nottingham French Studies 33, no. 2 (1994): 47–54. http://dx.doi.org/10.3366/nfs.1994-2.006.

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44

QIU, LU, YANG-LI CHE, and ZONG-QING WANG. "A taxonomic study of Eupolyphaga Chopard, 1929 (Blattodea: Corydiidae: Corydiinae)." Zootaxa 4506, no. 1 (2018): 1. http://dx.doi.org/10.11646/zootaxa.4506.1.1.

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The cockroach genus Eupolyphaga is revised. Twenty species and two subspecies are recognized, with thirteen species and two subspecies are new to science: E. daweishana sp. nov., E. dongi sp. nov., E. fengi sp. nov., E. hanae sp. nov., E. hupingensis sp. nov., E. maculata sp. nov., E. nigrifera sp. nov., E. nigrinotum sp. nov., E. pilosa sp. nov., E. robusta sp. nov., E. shennongensis sp. nov., E. wooi sp. nov., E. xuorum sp. nov., E. everestiana reni subsp. nov., and E. fengi yongshengensis subsp. nov. Homœogamia sinensis Saussure is placed as a junior synonym of E. sinensis (Walker) and the replaced name E. limbata (Kirby) for Homœogamia sinensis is invalid, the status of Eupolyphaga thibetana (Chopard) is recovered. Male genitalia of species in the genus is described and illustrated. Females and oothecae of some species are described and illustrated. Distribution maps and a checklist of Eupolyphaga are provided. A key to males of Eupolyphaga is given. Plenty habitat photographs are shown.

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45

Wang, Hui-Qiang, Jin Hu, Hai-Yan Yan, Shuo Wu, and Yu-Huan Li. "Corydaline inhibits enterovirus 71 replication by regulating COX-2 expression." Journal of Asian Natural Products Research 19, no. 11 (2017): 1124–33. http://dx.doi.org/10.1080/10286020.2017.1386658.

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46

Qiu, Lu, Yan-Li Che, and Zong-Qing Wang. "Contributions to some Corydiinae genera (Blattodea: Corydioidea: Corydiidae) from China." Journal of Natural History 52, no. 21-22 (2018): 1433–61. http://dx.doi.org/10.1080/00222933.2018.1463406.

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47

Guo, Pengcheng, Qizheng Wang, Xiaoqiang Xiang, et al. "Establishment of Dissolution Test Method for Multi-Components in Traditional Chinese Medicine Preparations Based on In Vitro–In Vivo Correlation." Pharmaceuticals 17, no. 8 (2024): 1065. http://dx.doi.org/10.3390/ph17081065.

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In this study, a multi-component integrated dissolution evaluation system of Yuanhu Zhitong tablets (YZTs) was established based on in vitro and in vivo correlation (IVIVC). The dissolution tests of five quality markers (Q-markers), including tetrahydropalmatine, α-allocryptopine, protopine, corydaline, and byakangelicin, in YZTs were conducted under different dissolution conditions, and pharmacokinetic studies were performed in beagle dogs to construct a correlation model using numerical deconvolution. The data of the five ingredients were integrated in vitro and in vivo according to the biopharmaceutical classification system (BCS) to establish an IVIVC integrating multiple Q-markers. The dissolution media with the best correlation of components were obtained and validated. The results showed that all five components were classified as BCS I compounds, and α-allocryptopine, byakangelicin, tetrahydropalmatine, and corydaline showed good correlation in the paddle method, 75 rpm, with dissolution media of artificial gastric fluid, acetate buffer, acetate buffer and 0.1 M HCl, respectively. Protopine showed good correlation in the paddle method, 100 rpm, with dissolution media of 0.1 M HCl. The integrated BCS I Q-markers showed the best correlation in the medium of acetate buffer. The multi-component integrated dissolution evaluation system established in this experiment accurately predicted the pharmacokinetic data of YZTs by verifying the media, which can be used for the quality control of YZTs. The present study provides an effective and promising strategy for the dissolution evaluation for traditional Chinese medicine preparations.

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48

Cairns, Lucille. "Gide's "Corydon": The Politics of Sexuality and Sexual Politics." Modern Language Review 91, no. 3 (1996): 582. http://dx.doi.org/10.2307/3734086.

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49

Luo, Tian, Xuemei Deng, Zhao Li, Dan Liu, Huaixiu Wen, and Zhen Wang. "Synthesis and anti-hepatocellular carcinoma effects of corydamine from Hypecoum Leptocarpum." Phytochemistry Letters 51 (October 2022): 119–26. http://dx.doi.org/10.1016/j.phytol.2022.08.006.

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50

Selvaraj, Baskar, Dae Won Kim, Ki-Yeon Yoo, et al. "Neuroprotective mechanism of corydaline in glutamate-induced neurotoxicity in HT22 cells." International Journal of Oral Biology 49, no. 1 (2024): 10–17. http://dx.doi.org/10.11620/ijob.2024.49.1.10.

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