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Journal articles on the topic 'Cosolvent Mixtures'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Puentes-Lozada, Vanesa, Diego Ivan Caviedes-Rubio, Cristian Rincón-Guio, et al. "Thermodynamic Study of the Solubility of Triclocarban in Polyethylene Glycol 200 + Water Cosolvent Mixtures at Different Temperatures." Molecules 30, no. 12 (2025): 2631. https://doi.org/10.3390/molecules30122631.

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Background: Solubility is a fundamental physicochemical property in pharmaceutical, chemical and environmental industrial processes. Regarding Triclocarban (TCC), a broad-spectrum antimicrobial, solubility is particularly challenging due to its low aqueous solubility and hydrophobic nature; these challenges can be addressed by some effective techniques such as cosolvency, which allows one to increase the solubility of drugs by several orders of magnitude. This study aims to thermodynamically evaluate the solubility of TCC in cosolvent mixtures of PEG 200 + water at different temperatures. Meth

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2

Ortiz, Claudia Patricia, Rossember Edén Cardenas-Torres, Fleming Martínez, and Daniel Ricardo Delgado. "Solubility of Sulfamethazine in the Binary Mixture of Acetonitrile + Methanol from 278.15 to 318.15 K: Measurement, Dissolution Thermodynamics, Preferential Solvation, and Correlation." Molecules 26, no. 24 (2021): 7588. http://dx.doi.org/10.3390/molecules26247588.

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Solubility of sulfamethazine (SMT) in acetonitrile (MeCN) + methanol (MeOH) cosolvents was determined at nine temperatures between 278.15 and 318.15 K. From the solubility data expressed in molar fraction, the thermodynamic functions of solution, transfer and mixing were calculated using the Gibbs and van ’t Hoff equations; on the other hand, the solubility data were modeled according to the Wilson models and NRTL. The solubility of SMT is thermo-dependent and is influenced by the solubility parameter of the cosolvent mixtures. In this case, the maximum solubility was achieved in the cosolvent

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3

Jouyban, Abolghasem. "Review of the cosolvency models for predicting solubility of drugs in water-cosolvent mixtures." Journal of Pharmacy & Pharmaceutical Sciences 11, no. 1 (2008): 32. http://dx.doi.org/10.18433/j3pp4k.

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The cosolvency models presented from 1960 to 2007 were reviewed and their accuracies for correlating and/or predicting the solubility of drugs in water-cosolvent mixtures were discussed. The cosolvency models could be divided into theoretical, semi-empirical and empirical models, the first group of models provide basic information from the solution, while the last group of models are good suitable for solubility correlation studies. The simplest cosolvency model, i.e. the log-linear model of Yalkowsky, provides an estimate of drug solubility in water-cosolvent mixtures using aqueous solubility

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4

Zheng, Yan-Zhen, Hong Chen, Yu Zhou, Deng Geng, Hong-Yan He, and Li-Ming Wu. "The structure and hydrogen-bond properties of N-alkyl-N-methyl-pyrrolidinium bis(trifluoromethylsulfonyl)imide and DMSO mixtures." Physical Chemistry Chemical Physics 22, no. 48 (2020): 28021–31. http://dx.doi.org/10.1039/d0cp03640d.

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Mixing ionic liquids (ILs) with cosolvents can extend the practical applications of ILs and overcome the drawbacks of neat ILs. Studies on the structure and hydrogen-bond interaction properties of IL–cosolvent mixtures is essential for chemical applications.

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5

Tinjaca, Dario A., Maria M. Muñoz, Fleming Martinez, Abolghasem Jouyban, and William E. Acree Jr. "Apparent Specific Volumes of Sucrose in Different Aqueous Cosolvent Mixtures at 298.2 K." Pharmaceutical Sciences 24, no. 4 (2018): 324–31. http://dx.doi.org/10.15171/ps.2018.46.

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Background: Sucrose is the most widely used sweetener in foods and pharmaceuticals. Apparent specific volumes of this excipient in aqueous cosolvent mixtures are not available. Thus, the main objective of this research was to determine this property by measuring the density of several solutions of sucrose in {cosolvent + water} mixtures at 298.2 K. Methods: Sucrose dissolutions were prepared gravimetrically and a thermostatically controlled digital oscillatory method was used to measure the dissolutions density. Results: From density values of sucrose dissolutions and cosolvent mixtures the ap

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6

Trujillo-Trujillo, Carlos Francisco, Fredy Angarita-Reina, Mauricio Herrera, et al. "Thermodynamic Analysis of the Solubility of Sulfadiazine in (Acetonitrile 1-Propanol) Cosolvent Mixtures from 278.15 K to 318.15 K." Liquids 3, no. 1 (2022): 7–18. http://dx.doi.org/10.3390/liquids3010002.

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Drug solubility is one of the most significant physicochemical properties as it is related to drug design, formulation, quantification, recrystallization, and other processes, so understanding it is crucial for the pharmaceutical industry. In this context, this research presents the thermodynamic analysis of the solubility of sulfadiazine (SD) in cosolvent mixtures {acetonitrile + 1-propanol} at 9 temperatures (278.15 K–318.15 K), which is a widely used drug in veterinary therapy, and two solvents of high relevance in the pharmaceutical industry, respectively. The solubility of SD, in cosolven

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7

Martínez, Fleming, María Ángeles Peña, and Abolghasem Jouyban. "Dissolution Thermodynamics and Preferential Solvation of Phenothiazine in Some Aqueous Cosolvent Systems." Liquids 4, no. 2 (2024): 443–55. http://dx.doi.org/10.3390/liquids4020024.

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Published equilibrium mole fraction solubilities of phenothiazine in ethanol, propylene glycol and water as mono-solvents at several temperatures were investigated to find standard apparent thermodynamic quantities of dissolution mixing and solvation based on the van’t Hoff and Gibbs equations. Further, by processing the reported mole fraction solubility values of phenothiazine in some aqueous cosolvent mixtures at T/K = 298.2, the inverse Kirkwood–Buff integrals treatment demonstrated preferential hydration of phenothiazine in water-rich mixtures and preferential solvation of this agent by co

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8

Caviedes-Rubio, Diego Ivan, Claudia Patricia Ortiz, Fleming Martinez, and Daniel Ricardo Delgado. "Thermodynamic Assessment of Triclocarban Dissolution Process in N-Methyl-2-pyrrolidone + Water Cosolvent Mixtures." Molecules 28, no. 20 (2023): 7216. http://dx.doi.org/10.3390/molecules28207216.

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Solubility is one of the most important physicochemical properties due to its involvement in physiological (bioavailability), industrial (design) and environmental (biotoxicity) processes, and in this regard, cosolvency is one of the best strategies to increase the solubility of poorly soluble drugs in aqueous systems. Thus, the aim of this research is to thermodynamically evaluate the dissolution process of triclocarban (TCC) in cosolvent mixtures of {N-methyl-2-pyrrolidone (NMP) + water (W)} at seven temperatures (288.15, 293.15, 298.15, 303.15, 308.15, 313.15 and 318.15 K). Solubility is de

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9

Chalikian, Tigran V., and Soyoung Lee. "Solvation in Solvent-Cosolvent Mixtures." Biophysical Journal 96, no. 3 (2009): 602a. http://dx.doi.org/10.1016/j.bpj.2008.12.3180.

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10

Masegosa, R. M., I. Hernández-Fuentes, I. Fernández de Piérola, and A. Horta. "Polystyrene fluorescence in cosolvent mixtures." Polymer 28, no. 2 (1987): 231–35. http://dx.doi.org/10.1016/0032-3861(87)90409-5.

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11

Kipkemboi, PK, and AJ Easteal. "Solvent Polarity Studies of the Water+t-Butyl Alcohol and Water+t-Butylamine Binary Systems With the Solvatochromic Dyes Nile Red and Pyridinium-N-phenoxide Betaine, Refractometry and Permittivity Measurements." Australian Journal of Chemistry 47, no. 9 (1994): 1771. http://dx.doi.org/10.1071/ch9941771.

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The empirical solvent polarity parameters ENR and ET for the solvatochromic compounds Nile Red (1) and pyridinium-N-phenoxide betaine (2), respectively, have been determined as a function of composition for water+t -butyl alcohol and water+t-butylamine binary mixtures, over the whole composition range at 298 K. For both systems the two parameters vary with composition in a strongly non-linear fashion, and the polarity of the mixture decreases with increasing proportion of the organic cosolvent. The non-linear variation of the polarity parameters is attributed to water-cosolvent hydrophobic int

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12

Vargas E., Edgar F., Helber J. Barbosa B., and Fleming Martínez. "The Jouyban-Acree model’s usefulness for estimating ibuprofen and naproxen solubility in some cosolvent mixtures." Ingeniería e Investigación 28, no. 2 (2008): 30–36. http://dx.doi.org/10.15446/ing.investig.v28n2.14889.

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Estimating drug solubility in cosolvent mixtures has been an important pharmaceutical science research field at theoretical and practical levels for several decades. The validity of an adapted version of the Jouyban-Acree (J-A) model for predicting ibuprofen (IBP) and naproxen (NAP) solubility in propylene glycol + water cosolvent mixtures was thus evaluated. The usefulness of Yalkowsky and Roseman’s solubility log-linear equation was also evaluated for the same drugs in such cosolvent system. The solubility estimation was studied as a function of temperature and cosolvent composition. The J-A

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13

He, Meiqi, Wenwen Zheng, Nannan Wang, Hanlu Gao, Defang Ouyang, and Zunnan Huang. "Molecular Dynamics Simulation of Drug Solubilization Behavior in Surfactant and Cosolvent Injections." Pharmaceutics 14, no. 11 (2022): 2366. http://dx.doi.org/10.3390/pharmaceutics14112366.

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Surfactants and cosolvents are often combined to solubilize insoluble drugs in commercially available intravenous formulations to achieve better solubilization. In this study, six marketed parenteral formulations with surfactants and cosolvents were investigated on the aggregation processes of micelles, the structural characterization of micelles, and the properties of solvent using molecular dynamics simulations. The addition of cosolvents resulted in better hydration of the core and palisade regions of micelles and an increase in both radius of gyration (Rg) and the solvent accessible surfac

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14

Tagavifar, Mohsen, Sumudu Herath, Upali P. Weerasooriya, Kamy Sepehrnoori, and Gary Pope. "Measurement of Microemulsion Viscosity and Its Implications for Chemical Enhanced Oil Recovery." SPE Journal 23, no. 01 (2017): 66–83. http://dx.doi.org/10.2118/179672-pa.

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Summary The rheological behavior of microemulsion systems was systematically investigated with mixtures of oil, brine, surfactant, cosolvent, and in some cases polymer to determine their effects. A microemulsion-rheology model was developed and used to interpret the experimental results. The optimal microemulsion/oil-viscosity ratio without cosolvent was roughly 5:6, but it can be reduced to a more favorable ratio of approximately 2 by adding cosolvent. Even though the amount of cosolvent needed is case dependent, a clear trend of microemulsion-viscosity reduction with increasing cosolvent con

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15

Salmar, Siim, Jaak Järv, Tiina Tenno, and Ants Tuulmets. "Role of water in determining organic reactivity in aqueous binary solvents." Open Chemistry 10, no. 5 (2012): 1600–1608. http://dx.doi.org/10.2478/s11532-012-0080-8.

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AbstractKinetic data for organic reactions in various binary water-organic solvent mixtures were collected and quantitatively analysed in terms of linear-free-energy relationships by using tert-butyl chloride (2-chloro-2-methylpropane) solvolysis as the reference system. Linear similarity plots for these kinetic data were determined for solvent systems ranging from pure water mixtures up to considerable amount of cosolvent, and 161 similarity coefficients were calculated from slopes of these plots. The existence of these linear plots demonstrated that the solvent effects are of some common nat

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16

Baracaldo-Santamaría, Daniela, Carlos Alberto Calderon-Ospina, Claudia Patricia Ortiz, Rossember Edén Cardenas-Torres, Fleming Martinez, and Daniel Ricardo Delgado. "Thermodynamic Analysis of the Solubility of Isoniazid in (PEG 200 + Water) Cosolvent Mixtures from 278.15 K to 318.15 K." International Journal of Molecular Sciences 23, no. 17 (2022): 10190. http://dx.doi.org/10.3390/ijms231710190.

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The solubility of drugs in cosolvent systems of pharmaceutical interest is of great importance for understanding and optimizing a large number of processes. Here, we report the solubility of isoniazid in nine (PEG 200 + water) cosolvent mixtures at nine temperatures (278.15, 283.15, 288.15, 293.15, 298.15, 303.15, 308.15, and 318.15 K) determined by UV–vis spectrophotometry. From the solubility data, the thermodynamic solution, mixing, and transfer functions were calculated in addition to performing the enthalpy–entropy compensation analysis. The solubility of isoniazid depends on the concentr

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17

Ortiz, Claudia Patricia, Rossember Edén Cardenas-Torres, Mauricio Herrera, and Daniel Ricardo Delgado. "Thermodynamic Analysis of the Solubility of Propylparaben in Acetonitrile–Water Cosolvent Mixtures." Sustainability 15, no. 6 (2023): 4795. http://dx.doi.org/10.3390/su15064795.

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Parabens are substances used in the food, pharmaceutical and cosmetic industries. Recent studies have indicated that these substances have toxic potential, cause endocrine disruption and can easily bioaccumulate; therefore, their physicochemical properties are of industrial, biological and environmental interest. Due to their potential use in the development of more efficient and cleaner processes, the design of environmental recovery strategies and more reasonable designs for solubility in cosolvent mixtures, studies of thermodynamic analysis and mathematical modeling are of great interest. T

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18

Guha, Prabir K., and Kiron K. Kundu. "Free energies and entropies of transfer of hydrogen halides from water to aqueous 2-methoxy ethanol and structuredness of the solvents." Canadian Journal of Chemistry 63, no. 4 (1985): 798–803. http://dx.doi.org/10.1139/v85-132.

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Standard free energies (ΔGt0) and entropies (ΔSt0) of transfer of HBr and HI from water to some aqueous solutions of 2-methoxy ethanol (ME) have been determined from emf measurements of the cells: Pt, H2 (g, 1 atm)/HBr (m), solvent/AgBr–Ag and Pt, H2 (g, 1 atm)/KOH (m1), KI (m2), solvent/AgI–Ag, respectively, at seven equidistant temperatures ranging from 15 to 45 °C. ΔGt0 values of HBr and HI as well as of HCl obtained from literature, and particularly that of the individual ions obtained by tetraphenylarsonium tetraphenylboron (TATB) assumption, suggest that while H+ is increasingly stabiliz

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19

WALSH, JOHN M., MICHAEL L. GREENFIELD, GEORGE D. IKONOMOU, and MARC D. DONOHUE. "HYDROGEN-BONDING COMPETITION IN ENTRAINER COSOLVENT MIXTURES." Chemical Engineering Communications 86, no. 1 (1989): 125–44. http://dx.doi.org/10.1080/00986448908940367.

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20

Smith, Scott A., Vinay Shenai, and Michael A. Matthews. "Diffusion in supercritical mixtures: CO2+ cosolvent + solutes." Journal of Supercritical Fluids 3, no. 4 (1990): 175–79. http://dx.doi.org/10.1016/0896-8446(90)90020-m.

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21

Jouyban-Gharamaleki, A. "Comparison of various cosolvency models for calculating solute solubility in water–cosolvent mixtures." International Journal of Pharmaceutics 177, no. 1 (1999): 93–101. http://dx.doi.org/10.1016/s0378-5173(98)00333-0.

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22

Dutta, Rupam, Gourhari Jana, Dipankar Mondal, et al. "The role of viscosity in various dynamical processes of different fluorophores in ionic liquid–cosolvent mixtures: a femtosecond fluorescence upconversion study." Photochemical & Photobiological Sciences 18, no. 6 (2019): 1359–72. http://dx.doi.org/10.1039/c9pp00045c.

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23

Hull, Katherine L., Desmond E. Schipper, and Allen G. Oliver. "Synthesis and structural characterization of CO2-soluble oxidizers [Bu4N]BrO3 and [Bu4N]ClO3 and their dissolution in cosolvent-modified CO2 for reservoir applications." RSC Advances 10, no. 73 (2020): 44973–80. http://dx.doi.org/10.1039/d0ra09563j.

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24

Servis, Michael J., Marek Piechowicz, S. Skanthakumar, and L. Soderholm. "Molecular-scale origins of solution nanostructure and excess thermodynamic properties in a water/amphiphile mixture." Physical Chemistry Chemical Physics 23, no. 14 (2021): 8880–90. http://dx.doi.org/10.1039/d1cp00082a.

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25

Syu, Sin-Yi, Chun-Jern Pan, and Chun-I. Lee. "Zinc-Lithium Dual Ion Deep Eutectic Mixtures As Electrolyte for Stable Zinc-Based Hybrid Batteries." ECS Meeting Abstracts MA2024-01, no. 5 (2024): 762. http://dx.doi.org/10.1149/ma2024-015762mtgabs.

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Anode-free zinc batteries (AFZBs) are proposed as promising energy storage systems due to their high energy density, low cost, high safety, and easy production characteristics. However, the high reactivity of water molecules can induce passivation and dendritic growth within zinc-based aqueous batteries, thereby affecting the durability of the battery. A deep eutectic solvent (DES) is a solvent created through a suitable combination of salts or zwitterions, acting as hydrogen bond acceptors (HBA) and hydrogen bond donors (HBD). Its melting point is considerably lower than the combined melting

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26

Rajbangshi, Juriti, and Ranjit Biswas. "Heterogeneous dynamics in [BMIM][PF6] + Cosolvent binary Mixtures: Does It depend upon cosolvent Polarity?" Journal of Molecular Liquids 341 (November 2021): 117342. http://dx.doi.org/10.1016/j.molliq.2021.117342.

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27

Gantiva, Mauricio, Alicia Yurquina, and Fleming Martínez R. "PERFORMANCE OF THE YALKOWSKY & ROSEMAN AND JOUYBAN & ACREE MODELS ESTIMATING THE SOLUBILITY OF KETOPROFEN IN ETHANOL + WATER COSOLVENT MIXTURES." Vitae 16, no. 3 (2009): 361–68. http://dx.doi.org/10.17533/udea.vitae.3017.

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Ketoprofen (KTP) is a widely used anti-inflammatory drug. In this paper the validity of a trained version of the Jouyban-Acree (J & A) model is evaluated to predict the solubility of KTP in ethanol + water cosolvent mixtures. The usefulness of the solubility log-linear equation proposed by Yalkowsky and Roseman (Y & R) is also evaluated for the same drug in this cosolvent system. The solubility estimation is studied as a function of temperature and cosolvent composition. The J & A and Y & R models require only the experimental solubility values in the pure solvents at all the t

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28

Guo, Qianjin, Qiang Liu, and Yixin Zhao. "Insights into the Structure and Dynamics of Imidazolium Ionic Liquid and Tetraethylene Glycol Dimethyl Ether Cosolvent Mixtures: A Molecular Dynamics Approach." Nanomaterials 11, no. 10 (2021): 2512. http://dx.doi.org/10.3390/nano11102512.

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In this work, the effect of molecular cosolvents tetraethylene glycol dimethyl ether (TEGDME) on the structure and versatile nature of mixtures of these compounds with imidazolium-based ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate ([bmim][PF6]) is analyzed and discussed at a molecular level by means of all-atom molecular dynamics (MD) simulations. In the whole concentration range of the binary mixtures, the structures and properties evolution was studied by means of systematic molecular dynamics simulations of the fraction of hydrogen bonds, the radial and spatial distribution

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29

Schroer, Martin A., Yong Zhai, D. C. Florian Wieland, et al. "Exploring the Piezophilic Behavior of Natural Cosolvent Mixtures." Angewandte Chemie International Edition 50, no. 48 (2011): 11413–16. http://dx.doi.org/10.1002/anie.201104380.

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30

Schroer, Martin A., Yong Zhai, D. C. Florian Wieland, et al. "Exploring the Piezophilic Behavior of Natural Cosolvent Mixtures." Angewandte Chemie 123, no. 48 (2011): 11615–18. http://dx.doi.org/10.1002/ange.201104380.

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31

Dewilde, Sven, Jonas Winters, Wim Dehaen, and Koen Binnemans. "Polymerization of PPTA in Ionic Liquid/Cosolvent Mixtures." Macromolecules 50, no. 8 (2017): 3089–100. http://dx.doi.org/10.1021/acs.macromol.7b00579.

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32

Miyako, Yasuhiro, Yinyan Zhao, Kazuo Takeshima, Takahiro Kataoka, Tetsurou Handa, and Rodolfo Pinal. "Solubility of hydrophobic compounds in water–cosolvent mixtures: Relation of solubility with water–cosolvent interactions." Journal of Pharmaceutical Sciences 99, no. 1 (2010): 293–302. http://dx.doi.org/10.1002/jps.21842.

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33

Minnick, David L., and Aaron M. Scurto. "Reversible and non-reactive cellulose separations from ionic liquid mixtures with compressed carbon dioxide." Chemical Communications 51, no. 63 (2015): 12649–52. http://dx.doi.org/10.1039/c5cc03519h.

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34

Ruidiaz, Miller A., Daniel R. Delgado, and Fleming Martínez. "PERFORMANCE OF THE JOUYBAN-ACREEAND YALKOWSKY-ROSEMAN MODELSFOR ESTIMATING THE SOLUBILITY OFINDOMETHACIN IN ETHANOL + WATERMIXTURES." Revista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturales 35, no. 136 (2023): 329–36. http://dx.doi.org/10.18257/raccefyn.35(136).2011.2513.

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Indomethacin (IMC) is an anti-inflammatory drug whose physiochemical properties in aqueous solutions have not been studied thoroughly. For this reason, in this work the validity of the Jouyban-Acree and Yalkowsky-Roseman models is evaluated to predict the solubility of this compound in ethanol + water cosolvent mixtures. The solubility estimation is studied as a function of temperature and cosolvent composition. Both models require only the experimental solubility values in the pure solvents at all the temperatures evaluated. The solubility calculated values by using both models deviate notori

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35

Voyiatzis, Evangelos, and Michael C. Böhm. "How does the entropy of ternary polymer–solvent–cosolvent mixtures depend on the molar solvent fraction?" RSC Advances 6, no. 99 (2016): 97018–21. http://dx.doi.org/10.1039/c6ra23340f.

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36

DELGADO, Daniel R., and Fleming MARTÍNEZ R. "THERMODYNAMIC STUDY OF THE SOLUBILITY OF SODIUM SULFADIAZINE IN SOME ETHANOL + WATER COSOLVENT MIXTURES." Vitae 17, no. 2 (2010): 191–98. http://dx.doi.org/10.17533/udea.vitae.6344.

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Sodium sulfadiazine (SD-Na) is a drug extensively used for the treatment of certain infections caused by several kinds of microorganisms. Although SD-Na is widely used nowadays in therapeutics, the physicochemical information about their aqueous solutions is not complete at present. In this context, by using the van’t Hoff and Gibbs equations the thermodynamic functions Gibbs energy, enthalpy, and entropy of solution for SD-Na in ethanol + water cosolvent mixtures, are evaluated from solubility data determined at temperatures from 278.15 to 308.15 K. The drug solubility is greatest in neat wat

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37

Ortiz, Claudia Patricia, Rossember Edén Cardenas-Torres, Mauricio Herrera, and Daniel Ricardo Delgado. "Numerical Analysis of Sulfamerazine Solubility in Acetonitrile + 1-Propanol Cosolvent Mixtures at Different Temperatures." Sustainability 15, no. 8 (2023): 6596. http://dx.doi.org/10.3390/su15086596.

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The current challenges of the pharmaceutical industry regarding the environmental impact caused by its waste have led to the design and development of more efficient industrial processes. In this context, solubility studies are at the core of different processes, such as formulation, preformulation, synthesis, purification, recrystallization, quantification, and quality control. This research evaluates the solubility of sulfamerazine (SMR) in acetonitrile + 1-propanol cosolvent mixtures at nine temperature levels with UV/vis spectrophotometry using the vial-shake method. According to the analy

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38

Jiménez, Jackson A., and Fleming Martínez. "THERMODYNAMIC MAGNITUDES OF MIXING AND SOLVATION OF ACETAMINOPHEN IN ETHANOL + WATER COSOLVENT MIXTURES." Revista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturales 30, no. 114 (2023): 87–100. http://dx.doi.org/10.18257/raccefyn.30(114).2006.2217.

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Based on van't Hoff and Gibbs equations the thermodynamic functions free energy, enthalpy, and entropy of solution, mixing and solvation of acetaminophen in ethanol + water cosolvent mixtures, were evaluated from solubility data determined at several temperatures. The solubility was greater at 90% m/m of ethanol at all temperatures studied. This result shows clearly the cosolvent effect present in this system. The solvation of this drug in the mixtures increases as the ethanol proportion is also increased. By means of enthalpy-entropy compensation analysis, a more complex behavior for solution

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Zelaya, James R., and Gary C. Tepper. "Cloud Point Behavior of Poly(trifluoroethyl methacrylate) in Supercritical CO2–Toluene Mixtures." Molecules 30, no. 6 (2025): 1199. https://doi.org/10.3390/molecules30061199.

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Supercritical CO2 (scCO2) is a versatile solvent for polymer processing; however, many partially fluorinated polymers exhibit limited solubility in neat scCO2. Organic cosolvents such as toluene can enhance polymer–solvent interactions, thereby improving solubility. The cloud point behavior of poly(2,2,2-trifluoroethyl methacrylate) (poly(TFEMA)) at 3 wt% concentration in scCO2–toluene binary mixtures was investigated over a temperature range of 31.5–50 °C and toluene contents of 0–20 wt%. Solvent mixture densities were estimated using the Altuin–Gadetskii–Haar–Gallagher–Kell (AG–HGK) equation

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40

Prasad, V. Siva. "Thermodynamic studies in ternary mixtures containing water, formamide and t- butanol at 298.15 K." International Journal of Science and Social Science Research 1, no. 4 (2024): 147–56. https://doi.org/10.5281/zenodo.13367131.

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At 298.15 K, ultrasonic speeds and the isentropic compressibilities of aqueous solutions containing formamide (F) + t-butanol have been measured. As the concentration of formamide in the cosolvent (aqueous formamide) increases, it is observed that the concentrations of t-butanol at which isentropic compressibility becomes minimum and ultrasonic speed becomes maximum decrease. This behavior suggests that compared to aqueous t-butanol, aqueous ternary solutions are less structured. The concentration dependence of excess isentropic compressibility and excess ultrasonic speed very nicely reflects

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41

Delgado, Daniel R., Fleming Martinez, María Ángeles Peña, Abolghasem Jouyban, and William E. Acree. "Effect of Ethanol on the Solubility and Apparent Specific Volume of Sodium Sulfadiazine in Aqueous Mixtures." Journal of Pharmaceutical and BioTech Industry 2, no. 2 (2025): 5. https://doi.org/10.3390/jpbi2020005.

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The main objective of this research was to correlate the equilibrium solubility of sodium sulfadiazine in several {ethanol (EtOH, 1) + water (2)} mixtures reported in mass/volume and mass/mass percentages at different temperatures. Aqueous solubility of sodium sulfadiazine decreases almost linearly with decreasing temperature, but it decreases non-linearly with the addition of EtOH to water. Logarithmic solubility was adequately correlated with a bivariate model involving temperature and mixture composition. These solubility results were also well correlated with the Jouyban–Acree-based models

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42

Gantiva, Mauricio, Alicia Yurquina, and Fleming Martínez. "Solution Thermodynamics of Ketoprofen in Ethanol + Water Cosolvent Mixtures." Journal of Chemical & Engineering Data 55, no. 1 (2010): 113–18. http://dx.doi.org/10.1021/je9002866.

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43

Yun, S. L. Jimmy, Angela K. Dillow, and Charles A. Eckert. "Density Measurements of Binary Supercritical Fluid Ethane/Cosolvent Mixtures." Journal of Chemical & Engineering Data 41, no. 4 (1996): 791–93. http://dx.doi.org/10.1021/je960032v.

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44

Chatjigakis, Alexis K., Cecile Donze, Anthony W. Coleman, and Philippe Cardot. "Solubility behavior of .beta.-cyclodextrin in water/cosolvent mixtures." Analytical Chemistry 64, no. 14 (1992): 1632–34. http://dx.doi.org/10.1021/ac00038a022.

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45

Walsh, John M., and Marc D. Donohue. "Hydrogen bonding in entrainer cosolvent mixtures: A parametric analysis." Fluid Phase Equilibria 52 (December 1989): 397–404. http://dx.doi.org/10.1016/0378-3812(89)80345-0.

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46

Tee, Oswald S., and John A. Enos. "Hydrolysis of p-nitrophenyl alkanoates in aqueous organic solvent mixtures. The dispersal of aggregates and the uncoiling of n-alkyl chains." Canadian Journal of Chemistry 66, no. 12 (1988): 3027–30. http://dx.doi.org/10.1139/v88-468.

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Rate constants have been measured for the hydrolysis of six p-nitrophenyl alkanoates (C2, C4, C6, C8, C10, and C12) in basic aqueous media containing up to 80% (v/v) of the cosolvents: ethylene glycol (EG), 2-methoxyethanol (2ME), 1,2-dimethoxyethane (DME, glyme), bis(2-methoxyethyl) ether (diglyme), or DMSO. Addition of these cosolvents reduces and ultimately removes hydrophobic aggregation and coiling of the longer chain alkanoates, with the ether-type solvents (2ME, DME, and diglyme) being more efficient than EG or DMSO. Once the rate-lowering effects of aggregation and coiling have been re

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47

Talukdar, Himansu, Sibaprasad Rudra, and Kiron K. Kundu. "Thermodynamics of transfer of glycine, diglycine, and triglycine from water to aqueous solutions of urea, glycerol, and sodium nitrate." Canadian Journal of Chemistry 66, no. 3 (1988): 461–68. http://dx.doi.org/10.1139/v88-080.

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Standard free energies [Formula: see text] and entropies [Formula: see text] of transfer of glycine (G), diglycine (DG), and triglycine (TG), from water to aqueous mixtures of glycerol (GL) and urea (UH) have been determined from solubility measurements at different temperatures. This was also extended to an ionic cosolvent system like aqueous sodium nitrate solutions for G and DG. The observed [Formula: see text] and [Formula: see text]–composition profiles, as well as those obtained after correcting for the "cavity effect" as estimated by scaled particle theory (SPT), were examined in the li

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48

Ortiz, Claudia Patricia, Diego Ivan Caviedes-Rubio, Fleming Martinez, and Daniel Ricardo Delgado. "Solubility of Sulfamerazine in Acetonitrile + Ethanol Cosolvent Mixtures: Thermodynamics and Modeling." Molecules 29, no. 22 (2024): 5294. http://dx.doi.org/10.3390/molecules29225294.

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Sulfamerazine (SMR) is a drug used as an antibacterial agent in the treatment of some pathologies, such as bronchitis, prostatitis and urinary tract infections. Although this drug was developed in 1945 and, due to its toxicity, was partially displaced by penicillin, due to the current problem of bacterial resistance, compounds such as SMR have regained validity. In this context, the thermodynamic study of SMR in cosolvent mixtures of acetonitrile (MeCN) + ethanol (EtOH) at nine temperatures (278.15–318.15 K) is presented. The solubility of SMR was determined by UV–Vis spectrophotometry, follow

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Drozdov, Aleksey D., and Jesper de Claville Christiansen. "Equilibrium Swelling of Thermo-Responsive Gels in Mixtures of Solvents." Chemistry 4, no. 3 (2022): 681–700. http://dx.doi.org/10.3390/chemistry4030049.

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Thermo-responsive (TR) gels of the LCST (lower critical solution temperature) type swell in water at temperatures below their volume phase transition temperature Tc and collapse above the critical temperature. When water is partially replaced with an organic liquid, these materials demonstrate three different types of equilibrium solvent uptake diagrams at temperatures below, above, in the close vicinity of Tc. A model is developed for equilibrium swelling of TR gels in binary mixtures of solvents. It takes into account three types of phase transitions in TR gels driven by (i) aggregation of h

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Xu, Guangyu, Fanyuan Zhang, and Zhenghui Li. "Solubility Determination and Correlation of Teflubenzuron in Four Cosolvent Mixtures." Journal of Chemical & Engineering Data 67, no. 3 (2022): 717–26. http://dx.doi.org/10.1021/acs.jced.1c00537.

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