Academic literature on the topic 'CoTC'

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Journal articles on the topic "CoTC"

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Imamura, Daisuke, Ritsuko Kuwana, Hiromu Takamatsu, and Kazuhito Watabe. "Localization of Proteins to Different Layers and Regions of Bacillus subtilis Spore Coats." Journal of Bacteriology 192, no. 2 (2009): 518–24. http://dx.doi.org/10.1128/jb.01103-09.

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ABSTRACT Bacterial spores are encased in a multilayered proteinaceous shell known as the coat. In Bacillus subtilis, over 50 proteins are involved in spore coat assembly but the locations of these proteins in the spore coat are poorly understood. Here, we describe methods to estimate the positions of protein fusions to fluorescent proteins in the spore coat by using fluorescence microscopy. Our investigation suggested that CotD, CotF, CotT, GerQ, YaaH, YeeK, YmaG, YsnD, and YxeE are present in the inner coat and that CotA, CotB, CotC, and YtxO reside in the outer coat. In addition, CotZ and Cg
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Isticato, Rachele, Assunta Pelosi, Rita Zilhão, et al. "CotC-CotU Heterodimerization during Assembly of the Bacillus subtilis Spore Coat." Journal of Bacteriology 190, no. 4 (2007): 1267–75. http://dx.doi.org/10.1128/jb.01425-07.

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ABSTRACT We report evidence that CotC and CotU, two previously identified components of the Bacillus subtilis spore coat, are produced concurrently in the mother cell chamber of the sporulating cell under the control of σK and GerE and immediately assembled around the forming spore. In the coat, the two proteins interact to form a coat component of 23 kDa. The CotU-CotC interaction was not detected in two heterologous hosts, suggesting that it occurs only in B. subtilis. Monomeric forms of both CotU and CotC failed to be assembled at the surface of the developing spore and accumulated in the m
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Cangiano, Giuseppina, Antonio Mazzone, Loredana Baccigalupi, et al. "Direct and Indirect Control of Late Sporulation Genes by GerR of Bacillus subtilis." Journal of Bacteriology 192, no. 13 (2010): 3406–13. http://dx.doi.org/10.1128/jb.00329-10.

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ABSTRACT GerR is a sporulation-specific transcriptional factor of Bacillus subtilis that has been identified as a negative regulator of genes transcribed by σE-containing RNA polymerase and as a positive effector of the expression of three late sporulation genes. Here we confirmed that gerR transcription is dependent on σE-containing RNA polymerase but also observed that it requires the transcriptional regulator SpoIIID. The study of the role of GerR in regulating the expression of several late sporulation genes allowed us to observe that its effect is strongly positive on spoVIF, cotC, and co
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Isticato, Rachele, Assunta Pelosi, Maurilio De Felice, and Ezio Ricca. "CotE Binds to CotC and CotU and Mediates Their Interaction during Spore Coat Formation in Bacillus subtilis." Journal of Bacteriology 192, no. 4 (2009): 949–54. http://dx.doi.org/10.1128/jb.01408-09.

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ABSTRACT CotE is a morphogenic protein that controls the assembly of the coat, the proteinaceous structure that surrounds and protects the spore of Bacillus subtilis. CotE has long been thought to interact with several outer coat components, but such interactions were hypothesized from genetic experiment results and have never been directly demonstrated. To study the interaction of CotE with other coat components, we focused our attention on CotC and CotU, two outer coat proteins known to be under CotE control and to form a heterodimer. We report here the results of pull-down experiments that
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Isticato, Rachele, Giovanni Esposito, Rita Zilhão, et al. "Assembly of Multiple CotC Forms into the Bacillus subtilis Spore Coat." Journal of Bacteriology 186, no. 4 (2004): 1129–35. http://dx.doi.org/10.1128/jb.186.4.1129-1135.2004.

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ABSTRACT We report evidence that the CotC polypeptide, a previously identified component of the Bacillus subtilis spore coat, is assembled into at least four distinct forms. Two of these, having molecular masses of 12 and 21 kDa, appeared 8 h after the onset of sporulation and were probably assembled on the forming spore immediately after their synthesis, since no accumulation of either of them was detected in the mother cell compartment, where their synthesis occurs. The other two components, 12.5 and 30 kDa, were generated 2 h later and were probably the products of posttranslational modific
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Coste, Marine, Mikhail Tretiakov, Neil V. Shah, et al. "Does Percutaneous Achilles Tenotomy Yield Comparable Short-Term Outcomes to Combined Open Achilles Tenotomy with Posterior Capsulotomy in Pediatric Patients with Clubfoot?" Foot & Ankle Orthopaedics 4, no. 4 (2019): 2473011419S0015. http://dx.doi.org/10.1177/2473011419s00152.

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Category: Hindfoot, Midfoot/Forefoot, Congenital Introduction/Purpose: As the most common musculoskeletal congenital anomaly, clubfoot (congenital talipes equinovarus) represents a commonly-encountered entity for pediatric orthopaedic and foot/ankle surgeons. As we have observed a shift towards more conservative, cost-conscious approaches to management, this study sought to compare short-term (30-day) perioperative and postoperative outcomes (complications and reoperations) in clubfoot patients who underwent either percutaneous Achilles tenotomy (PT) or combined open Achilles tenotomy with pos
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Zilhão, Rita, Mónica Serrano, Rachele Isticato, Ezio Ricca, Charles P. Moran, and Adriano O. Henriques. "Interactions among CotB, CotG, and CotH during Assembly of the Bacillus subtilis Spore Coat." Journal of Bacteriology 186, no. 4 (2004): 1110–19. http://dx.doi.org/10.1128/jb.186.4.1110-1119.2004.

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ABSTRACT Spores formed by wild-type Bacillus subtilis are encased in a multilayered protein structure (called the coat) formed by the ordered assembly of over 30 polypeptides. One polypeptide (CotB) is a surface-exposed coat component that has been used as a vehicle for the display of heterologous antigens at the spore surface. The cotB gene was initially identified by reverse genetics as encoding an abundant coat component. cotB is predicted to code for a 43-kDa polypeptide, but the form that prevails in the spore coat has a molecular mass of about 66 kDa (herein designated CotB-66). Here we
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Negri, Alessandro, Wojciech Potocki, Adam Iwanicki, Michał Obuchowski, and Krzysztof Hinc. "Expression and display of Clostridium difficile protein FliD on the surface of Bacillus subtilis spores." Journal of Medical Microbiology 62, no. 9 (2013): 1379–85. http://dx.doi.org/10.1099/jmm.0.057372-0.

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The endospores of Bacillus subtilis can serve as a tool for surface presentation of heterologous proteins. The unique properties of the spore protective layers make them perfect vehicles for orally administered vaccines. In this study, we successfully displayed a fragment of Clostridium difficile FliD protein on the surface of B. subtilis spores using the CotB, CotC, CotG and CotZ spore coat proteins. The presence of the fusion proteins in the spore coat was verified by Western blotting and immunofluorescence microscopy. The amount of recombinant proteins was assessed by a dot-blot technique.
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Powell-Coffman, J. A., and R. A. Firtel. "Characterization of a novel Dictyostelium discoideum prespore-specific gene, PspB, reveals conserved regulatory sequences." Development 120, no. 6 (1994): 1601–11. http://dx.doi.org/10.1242/dev.120.6.1601.

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While Dictyostelium discoideum has been studied as a developmental system for decades, and many regulatory proteins have been cloned, the molecular mechanisms of cell-type-specific gene expression are poorly understood. In this paper we characterize a novel prespore gene, PspB, and undertake a comparative analysis of the regulatory regions in prespore-specific D. discoideum promoters. Sequence alignment of the PSPB gene product with other prespore-specific proteins identifies a conserved, repeated 12 amino acid cysteine-containing motif that may be involved in spore coat function or assembly.
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Giannakeas, Ilias N., Zahra Sharif Khodaei, and M. H. Ferri Aliabadi. "Structural Health Monitoring Cost Estimation of a Piezosensorized Aircraft Fuselage." Sensors 22, no. 5 (2022): 1771. http://dx.doi.org/10.3390/s22051771.

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Guided waves-based SHM systems are of interest in the aeronautic sector due to their lightweight, long interrogation distances, and low power consumption. In this study, a bottom-up framework for the estimation of the initial investment cost (COTC) and the added weight (WAW) associated with the integration of a SHM system to an aircraft is presented. The framework provides a detailed breakdown of the activities and their costs for the sensorization of a structure using a fully wired approach or the adoption of the printed diagnostic film. Additionally, the framework considers the difference be
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Dissertations / Theses on the topic "CoTC"

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Williams, Katharine. "Investigation of a synthetic approach to polyfunctionalised cyclohexenones related to the antheminone and carvotacetone natural products." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/investigation-of-a-synthetic-approach-to-polyfunctionalised-cyclohexenones-related-to-the-antheminone-and-carvotacetone-natural-products(bab498dd-4ab6-4f07-81f1-72b29cbb2f60).html.

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The natural product 2 crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxy-cyclohex-2-enone (COTC) was isolated from the microorganism Streptomyces griseosporeus in 1975. It was shown to exhibit 'cytotoxic and cancerostatic activity'. The simplified synthetic analogue 2-crotonyl-oxymethyl-cyclohex-2-enone (COMC) has been shown to exhibit potent anti tumour activity against murine and human tumours in cell culture. For several years, the Whitehead research group at the University of Manchester have focused on the synthesis of COTC and COMC analogues in an attempt to produce compounds with enhanced cyt
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Christou, Stephania. "Application of transition metal-mediated conjugate addition reactions to the synthesis of novel anti-tumour agents." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/application-of-transition-metalmediated-conjugate-addition-reactions-to-the-synthesis-of-novel-antitumour-agents(43488de6-e8f9-4d3a-8d66-5ccb17350e90).html.

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The Streptomyces metabolite 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC), the antheminones and the carvotacetone derivatives are all bioactive natural products, whose structure is based on the α oxymethyl-a,β-cyclohexenone moiety. Both COTC and antheminone A have been shown to exhibit cytotoxic and cancerostatic activity with low toxicity. The potent biological activity of these natural products has instigated numerous investigations into the synthesis of novel analogues in an attempt to determine the key structural features necessary for optimum bioactivity. The synt
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Liska, Olga. "Effect of CTCF and Cohesin on the dynamics of RNA polymerase II transcription and coupled pre-messenger RNA processing." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:ba9454b8-4498-42c8-bc4c-16dd971af164.

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The CCCTC-binding factor (CTCF) is a versatile, multifunctional zinc-finger protein involved in a broad spectrum of cellular functions. In mammalian cells, CTCF functions together with the Cohesin complex, an essential regulator of sister chromatid cohesion. Together, CTCF and Cohesin have been shown to regulate gene expression at a genome-wide level in mammalian cells. In the yeast Saccharomyces pombe, Cohesin has been implicated in transcription termination of convergently transcribed genes, in a cell cycle dependent manner. The aim of this thesis was to investigate the possibility of direct
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Millar, Anne. "Wartime Training at Canadian Universities during the Second World War." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/33146.

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This dissertation provides an account of the contributions of Canadian universities to the Second World War. It examines the deliberations and negotiations of university, government, and military officials on how best to utilize and direct the resources of Canadian institutions of higher learning towards the prosecution of the war and postwar reconstruction. During the Second World War, university leaders worked with the Dominion Government and high-ranking military officials to establish comprehensive training programs on campuses across the country. These programs were designed to produce se
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Zhang, Lijuan. "Preparation and mechanical properties of CoTi and CoTi(Zr) intermetallic crystals." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288529.

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Piot, Jean-Marie. "Le Président René Coty." Lille 3 : ANRT, 1986. http://catalogue.bnf.fr/ark:/12148/cb375950724.

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Piot, Jean-Marie. "Le Président René Coty." Paris 2, 1985. http://www.theses.fr/1985PA020014.

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Deyi, Kakou. "La criminalite en cote d'ivoire." Caen, 1986. http://www.theses.fr/1986CAEN0008.

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La criminalite en cote d'ivoire est la consequence de la degradation des moeurs ainsi que de la disposition des valeurs traditionnelles africaines. La civilisation des pays developpes envahit irresistiblement les civilisations, les traditions des pays sous-developpes. Les progres scientifiques et technologiques qui tendent vers un mieux-etre, comportent cependant des mefaits qui sont la contrepartie ineluctable d'une civilisation qui semblent remettre en cause toutes les valeurs, y compris la religion et la morale. L'individu etant sensible au milieu, la civilisation d'aujourd'hui tendant a se
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Anderson, James, and Adam Honse. "Autonomous Terrain Mapping Using COTS Hardware." International Foundation for Telemetering, 2012. http://hdl.handle.net/10150/581743.

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ITC/USA 2012 Conference Proceedings / The Forty-Eighth Annual International Telemetering Conference and Technical Exhibition / October 22-25, 2012 / Town and Country Resort & Convention Center, San Diego, California<br>The paper describes the development of a robotic platform which can autonomously map terrain using a COTS infrared imaging and ranging system. The robotic system is based on an omnidirectional platform, and can navigate typical commercial indoor environments. An on-board processor performs surface reconstruction, and condenses the point clouds generated by the ranging system to
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Martin, Jean-Paul David Jean. "REPONDRE A COTE DE LA QUESTION /." [S.l.] : [s.n.], 1987. ftp://ftp.scd.univ-metz.fr/pub/Theses/1987/Martin.Jean_Paul.LMZ8702.pdf.

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Books on the topic "CoTC"

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Juan, Goytisolo. Coto vedado. Mondadori, 1995.

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Juan, Goytisolo. Coto vedado. 7th ed. Seix Barral, 1986.

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Meg, Jump, ed. Cote d'Azur. Berlitz, 1999.

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Barrios, Luisa. Luis Coto. Instituto Mexiquense de Cultura, 1997.

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Mendes, John. Cote ce cote la: Trinidad & Tobago dictionary. Syncreators, 1985.

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John, Mendes, ed. Cote ci cote la: Trinidad & Tobago dictionary. John Mendes, 2003.

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Cotī vālā Hindū. Neśanala Pabliśiṅga Hāusa, 2012.

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Hue, Pascal. Cote d'Ivoire: Bibliographie. Association IBISCUS, 1991.

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Pardo, Neus Olives. Bales de cotó. Voliana Edicions, 2013.

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Manufacture francʹaise des pneumatiques Michelin. Cote d'Azur, Monaco. 2nd ed. Michelin, cartes et guides, 2009.

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Book chapters on the topic "CoTC"

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Eberhard, F. "Cote D’Ivoire." In International Handbook of Universities. Palgrave Macmillan UK, 1989. http://dx.doi.org/10.1007/978-1-349-09323-6_24.

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Exotix Capital. "Cote d’Ivoire." In Exotix Developing Markets Guide. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-05867-8_12.

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Gooch, Jan W. "COT." In Encyclopedic Dictionary of Polymers. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_2974.

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van Roy, Frans, Volker Nimmrich, Anton Bespalov, et al. "COT." In Encyclopedia of Signaling Molecules. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_100296.

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Flacks, Simon. "Conclusion." In Law, Drugs and the Politics of Childhood. Routledge, 2021. http://dx.doi.org/10.4324/9780429282140-conc.

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Stylidis, Dimitrios, and Nikolaos Boukas. "Conclusion." In Tourism marketing in Western Europe. CABI, 2021. http://dx.doi.org/10.1079/9781789248753.conc.

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Abstract This chapter summarizes the whole volume by including the highlights of all eleven chapters. It also discusses the scope and limitations of the volume as well as recommendations for further studies on tourism marketing. It states that useful key lessons can be drawn from the volume, for country, region and city destination marketers, managers and policymakers.
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Stylidis, Dimitrios. "Conclusion." In Tourism planning and development in Western Europe. CABI, 2022. http://dx.doi.org/10.1079/9781800620797.conc.

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Abstract This concluding chapter reviews the previous chapters and outlines the main reasons that have made planning and policy essential to tourism development and planning in Western Europe. The main conclusion drawn is that sustained growth will be instrumental in supporting the economic recovery of many Western European countries following the COVID-19 pandemic. The chapter also provides directions for future research.
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Jaccheri, Letizia, and Marco Torchiano. "Classifying COTS Products." In Software Quality — ECSQ 2002. Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/3-540-47984-8_28.

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Van Der Schaaf, Kjeld, and Ruud Overeem. "COTS Correlator Platform." In The Square Kilometre Array: An Engineering Perspective. Springer Netherlands, 2005. http://dx.doi.org/10.1007/1-4020-3798-8_27.

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Brooks, Linda. "Costing COTS Integration." In COTS-Based Software Systems. Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-540-24645-9_33.

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Conference papers on the topic "CoTC"

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Biduś, Natalia, Piotr Banachowicz, and Szymon Buda. "Application of lithium n-Butylselenolate in the Total Syntheses of (+)-Pericosine B, (+)-Pericosine C, (+)-COTC and 7-Chloro-analogue of (+)-Gabosine C." In 1st International Electronic Conference on Catalysis Sciences. MDPI, 2020. http://dx.doi.org/10.3390/eccs2020-07578.

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Ito, Minoru, Michio Kaneko, Seiji Nishimura, and Hidehiko Sato. "Development of Corrosion Resistant Steel for Bottom Plates of Crude Oil Tankers and Onboard Evaluation Results." In ASME 2012 31st International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/omae2012-83821.

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Pitting corrosion on the bottom plates of cargo oil tanks (COT) in very large crude carriers (VLCC) is very serious problem. Each tank may suffer up to 1,000 pits, with some reaching a depth of as much as 10 mm. As a result, the workload of repairing such pitting corrosions in periodical dock inspection is extremely heavy. Many studies have already been conducted to clarify the mechanism of pitting corrosion, but it has yet to be fully understood. We have clarified the pitting corrosion mechanism through onboard research on some VLCCs and various corrosion tests, in addition to the findings ob
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Ramot, Medy, Eran Weiss, and Niv Cohen. "Survey of Environmental Data for COTS (Commercial Off-the-Shelf) Used in Military Systems." In ASME 2005 Pacific Rim Technical Conference and Exhibition on Integration and Packaging of MEMS, NEMS, and Electronic Systems collocated with the ASME 2005 Heat Transfer Summer Conference. ASMEDC, 2005. http://dx.doi.org/10.1115/ipack2005-73025.

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COTS — Commercial Off-The-Shelf items — used in electronic military systems present advantages of being state-of-the-art technology, low cost and readily available on the market. Demand to reduce design lead-time and minimize cost bring on an increasing trend to use COTS in military applications. COTS manufacturers design the parts for moderate environmental conditions, which characterizes consumer goods, computers, telecommunications, and home entertainment industries. Military systems require reliable, high quality performance and survival in harsh environment. Therefore, in order to asses t
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Choi, Hoon-gyu, Jungmin Yoo, Taejoong Chung, Nakjung Choi, Taekyoung Kwon, and Yanghee Choi. "CoRC." In the tenth ACM/IEEE symposium. ACM Press, 2014. http://dx.doi.org/10.1145/2658260.2658275.

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Molino, Piero, Huaixiu Zheng, and Yi-Chia Wang. "COTA." In KDD '18: The 24th ACM SIGKDD International Conference on Knowledge Discovery and Data Mining. ACM, 2018. http://dx.doi.org/10.1145/3219819.3219851.

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Maly, Kurt, Mohammad Zubair, S. Balusani, A. Mathur, S. Sudeep, and W. Wolters. "DL-COTF." In the 2002 ACM symposium. ACM Press, 2002. http://dx.doi.org/10.1145/508791.508883.

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"COTS Workshop." In the 22nd international conference, chair John Dean, Tricia Oberndorf, and Mark Vigder. ACM Press, 2000. http://dx.doi.org/10.1145/337180.337821.

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Kim, Jong-Wook, Young-Tae Yang, Hyun-Soo Shin, and Ki-Young Yoon. "Load-Out, Towing and Float-Off Analysis for 105K COT of the First Ground Construction of Ship Type Structure." In ASME 2005 24th International Conference on Offshore Mechanics and Arctic Engineering. ASMEDC, 2005. http://dx.doi.org/10.1115/omae2005-67103.

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The 105K COT (105,000 DWT Crude Oil Tanker) is being continuously constructed at the ground yard of HHI (Hyundai Heavy Industries), Ulsan, Korea as the first ground construction for ship type structures. She is loaded out transversely from the quayside by skidding onto the DBU (Double Barge Unit). The DBU will then be towed to a pre-determined site and ballasted down to float-off the 105K COT from the DBU. This paper describes the motions, mooring forces, collision possibilities and constraint forces of DBU / 105K COT during load-out, towing and float-off of the 105K COT.
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Tanouye, Miranda M., and Vishesh Vikas. "Static and Stability Analysis of a Planar Compliant Tensegrity Mechanism." In ASME 2018 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/detc2018-85998.

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Traditional tensegrity mechanisms are comprised of compressive (rigid rods) and tensile members (strings). Compliant tensegrity mechanisms (CoTM) introduce springs alongside strings and rods, allowing these structures to be more adaptable and robust. The kinematic and stability analyses of such mechanisms will facilitate better behavioral understanding for control of such structures. Generally, the kinematic analysis assumes zero-free length (ZFL) springs which facilitates simplification of equations of motion. However, a general ZFL does not exist and the relaxation of ZFL assumption for a Co
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Ghaffarian, Reza. "Key Reliability Factors for IC and MEMS Packaging." In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-1155.

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Abstract During the last decade, research and development of microelectromechanical systems (MEMS) has shown a significant promise for a variety of commercial applications including automobile and medical purposes. For example, accelerometers are widely used for air bag in automobile and pressure sensors for various industrial applications. Some of the MEMS devices have potential to become the commercial-off-the-shelf (COTS) components. While high reliability/harsh environmental applications including aerospace require much more sophisticated technology development, they would achieve signific
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Reports on the topic "CoTC"

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Booth, Carol. Considering COTS. Defense Technical Information Center, 1998. http://dx.doi.org/10.21236/ada369389.

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Watkins, William M., Han Wei Lin, Kelly McClelland, et al. COTS software selection process. Office of Scientific and Technical Information (OSTI), 2006. http://dx.doi.org/10.2172/885111.

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Oberndorf, Patricia. COTS and Open Systems. Defense Technical Information Center, 1998. http://dx.doi.org/10.21236/ada634141.

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Carney, David J., Edwin J. Morris, and Patrick R. Place. Identifying Commercial Off-the-Shelf (COTS) Product Risks: The COTS Usage Risk Evaluation. Defense Technical Information Center, 2003. http://dx.doi.org/10.21236/ada418382.

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Alford, Lionel D. The Problem with Aviation Cots. Defense Technical Information Center, 1999. http://dx.doi.org/10.21236/ada372248.

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Adams, R. J., and S. Eslinger. COTS-Based Systems: Lessons Learned from Experiences with COTS Software Use on Space Systems. Defense Technical Information Center, 2001. http://dx.doi.org/10.21236/ada388705.

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Wagner, Eric. Evaluation of COTS Rad Detection Apps. Office of Scientific and Technical Information (OSTI), 2014. http://dx.doi.org/10.2172/1135822.

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Staley, Mary Jo, Patricia Oberndorf, and Carol A. Sledge. Using EVMS with COTS-Based Systems. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada403815.

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Sai, Vijay. COTS Acquisition Evaluation Process: Preacher's Practice. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada421675.

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Comella-Dorda, Santiago, John Dean, Grace Lewis, Edwin Morris, Patricia Oberndorf, and Erin Harper. A Process for COTS Software Product Evaluation. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada443491.

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