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Relevant bibliographies by topics / Cotranslational mRNA decay

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Academic literature on the topic 'Cotranslational mRNA decay'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 February 2022

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Journal articles on the topic "Cotranslational mRNA decay"

1

Liu, Yi, Qian Yang, and Fangzhou Zhao. "Synonymous but Not Silent: The Codon Usage Code for Gene Expression and Protein Folding." Annual Review of Biochemistry 90, no. 1 (2021): 375–401. http://dx.doi.org/10.1146/annurev-biochem-071320-112701.

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Codon usage bias, the preference for certain synonymous codons, is found in all genomes. Although synonymous mutations were previously thought to be silent, a large body of evidence has demonstrated that codon usage can play major roles in determining gene expression levels and protein structures. Codon usage influences translation elongation speed and regulates translation efficiency and accuracy. Adaptation of codon usage to tRNA expression determines the proteome landscape. In addition, codon usage biases result in nonuniform ribosome decoding rates on mRNAs, which in turn influence the cot

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2

Winstall, E., M. Gamache, and V. Raymond. "Rapid mRNA degradation mediated by the c-fos 3' AU-rich element and that mediated by the granulocyte-macrophage colony-stimulating factor 3' AU-rich element occur through similar polysome-associated mechanisms." Molecular and Cellular Biology 15, no. 7 (1995): 3796–804. http://dx.doi.org/10.1128/mcb.15.7.3796.

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The different 3' noncoding AU-rich elements (ARE) that mediate the degradation of many short-lived mRNAs may function through distinct decay pathways; translation-dependent and -independent mechanisms have been proposed. To investigate the cotranslational model, we designed an expression system that exploits the properties of the ferritin iron-responsive element to shuttle chimeric mRNAs from ribonucleoproteins to polyribosomes. The iron-responsive element was introduced in the 5' untranslated regions of alpha-globin mRNAs that harbored in their 3' untranslated regions either the c-fos ARE or

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3

Small-Howard, Andrea, Nadya Morozova, Zoia Stoytcheva, et al. "Supramolecular Complexes Mediate Selenocysteine Incorporation In Vivo." Molecular and Cellular Biology 26, no. 6 (2006): 2337–46. http://dx.doi.org/10.1128/mcb.26.6.2337-2346.2006.

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ABSTRACT Selenocysteine incorporation in eukaryotes occurs cotranslationally at UGA codons via the interactions of RNA-protein complexes, one comprised of selenocysteyl (Sec)-tRNA[Ser]Sec and its specific elongation factor, EFsec, and another consisting of the SECIS element and SECIS binding protein, SBP2. Other factors implicated in this pathway include two selenophosphate synthetases, SPS1 and SPS2, ribosomal protein L30, and two factors identified as binding tRNA[Ser]Sec, termed soluble liver antigen/liver protein (SLA/LP) and SECp43. We report that SLA/LP and SPS1 interact in vitro and in

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4

Yu, Xiang, Matthew R. Willmann, Stephen J. Anderson, and Brian D. Gregory. "Genome-Wide Mapping of Uncapped and Cleaved Transcripts Reveals a Role for the Nuclear mRNA Cap-Binding Complex in Cotranslational RNA Decay in Arabidopsis." Plant Cell 28, no. 10 (2016): 2385–97. http://dx.doi.org/10.1105/tpc.16.00456.

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5

Curatola, A. M., M. S. Nadal, and R. J. Schneider. "Rapid degradation of AU-rich element (ARE) mRNAs is activated by ribosome transit and blocked by secondary structure at any position 5' to the ARE." Molecular and Cellular Biology 15, no. 11 (1995): 6331–40. http://dx.doi.org/10.1128/mcb.15.11.6331.

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The 3' noncoding region (NCR) AU-rich element (ARE) selectively confers rapid degradation on many mRNAs via a process requiring translation of the message. The role of cotranslation in destabilization of ARE mRNAs was examined by insertion of translation-blocking stable secondary structure at different sites in test mRNAs containing either the granulocyte-macrophage colony-stimulating factor (GM-CSF) ARE or a control sequence. A strong (-80 kcal/mol [1 kcal = 4.184 kJ]) but not a moderate (-30 kcal/mol) secondary structure prevented destabilization of mRNAs when inserted at any position upstre

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6

Tat, Trinh To, Patricia A. Maroney, Sangpen Chamnongpol, Jeff Coller, and Timothy W. Nilsen. "Cotranslational microRNA mediated messenger RNA destabilization." eLife 5 (April 8, 2016). http://dx.doi.org/10.7554/elife.12880.

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MicroRNAs are small (22 nucleotide) regulatory molecules that play important roles in a wide variety of biological processes. These RNAs, which bind to targeted mRNAs via limited base pairing interactions, act to reduce protein production from those mRNAs. Considerable evidence indicates that miRNAs destabilize targeted mRNAs by recruiting enzymes that function in normal mRNA decay and mRNA degradation is widely thought to occur when mRNAs are in a ribosome free state. Nevertheless, when examined, miRNA targeted mRNAs are invariably found to be polysome associated; observations that appear to

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7

Ibrahim, Fadia, Jan Oppelt, Manolis Maragkakis, and Zissimos Mourelatos. "TERA-Seq: true end-to-end sequencing of native RNA molecules for transcriptome characterization." Nucleic Acids Research, August 24, 2021. http://dx.doi.org/10.1093/nar/gkab713.

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Abstract Direct sequencing of single, native RNA molecules through nanopores has a strong potential to transform research in all aspects of RNA biology and clinical diagnostics. The existing platform from Oxford Nanopore Technologies is unable to sequence the very 5′ ends of RNAs and is limited to polyadenylated molecules. Here, we develop True End-to-end RNA Sequencing (TERA-Seq), a platform that addresses these limitations, permitting more thorough transcriptome characterization. TERA-Seq describes both poly- and non-polyadenylated RNA molecules and accurately identifies their native 5′ and

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Dissertations / Theses on the topic "Cotranslational mRNA decay"

1

Trinh, Tat To. "REGULATION OF DROSOPHILA mRNA STABILITY BY DEADENYLATION ELEMENTS AND miRNAs." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1436441986.

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