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1

Panda, Vandana Sanjeev, and Aneesul Islam. "In vivo anti-inflammatory activity of Garcinia indica fruit rind (Kokum) in rats." Journal of Phytopharmacology 2, no. 5 (2013): 8–14. http://dx.doi.org/10.31254/phyto.2013.2502.

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The aqueous extract of Garcinia indica fruit rind (GIE) was studied for anti-inflammatory activity in carrageenan induced paw edema and cotton pellet induced granuloma in rats. Wistar rats were orally administered GIE (400 mg/kg and 800 mg/kg) and the standard drug diclofenac sodium (10 mg/kg) 60 min prior to a subcutaneous injection of carrageenan (0.1 ml of 1% w/v) into their right hind paws to produce edema. The paw volumes were measured at various time intervals to assess the effect of drug treatment. In the granuloma model, 4 sterile cotton pellets were implanted in the ventral region in
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2

Maxia, Andrea, Cinzia Sanna, Maria Assunta Frau, Alessandra Piras, Manvendra Singh Karchuli та Veena Kasture. "Anti-inflammatory Activity of Pistacia lentiscus Essential Oil: Involvement of IL-6 and TNF-α". Natural Product Communications 6, № 10 (2011): 1934578X1100601. http://dx.doi.org/10.1177/1934578x1100601033.

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The topical anti-inflammatory activity of essential oil of Pistacia lentiscus L. was studied using carrageenan induced rat paw edema and cotton pellet induced granuloma. The effect on serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in rats inserted with cotton pellet was also investigated. On topical application, the oil exhibited a significant decrease in paw edema. The oil also inhibited cotton pellet-induced granuloma, and reduced serum TNF-α and IL-6. It can be concluded that the essential oil of Pistacia lentiscus reduces leukocyte migration to the damaged tissue and exhibi
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3

Abdul-Ghani, MR, and AS Naser. "Assessment anti-granuloma activity of Alpha-lipoic acid in chicks’ models." Journal of the Hellenic Veterinary Medical Society 74, no. 1 (2023): 5277–82. http://dx.doi.org/10.12681/jhvms.29033.

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Background: Alpha-lipoic acid is an anti-inflammatory and antioxidant agent that has free radical scavenging characteristics as well as better effects on the recycling of other cellular antioxidants.Aim: The present study was made to assess the anti-granuloma of Alpha-lipoic acid by the cotton pellet granuloma method.Method: The chicks weighing around 100-150 g were selected, the Alpha-lipoic acid was administered at the following dose of 20, 40 & 80 mg/kg body weight respectively after insertion of cotton pellets into the groin region of chicks.Results: By using the up-and-down technique,
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4

Mizukawa, Hiromi, Kazuo Yoshida, Akie Honmura, et al. "The Effect of Orengedokuto on Experimentally-inflamed Rats." American Journal of Chinese Medicine 21, no. 01 (1993): 71–78. http://dx.doi.org/10.1142/s0192415x93000091.

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The inhibitory effect of Orenge dokuto on lipid peroxide and sialidase was investigated using rats affected with carrageenin cotton pellet-induced granuloma and adjuvant arthritis. As a result, in the case of rats with carrageenin cotton pellet-induced granuloma, a significant inhibitory effect on granuloma formation was observed in the Orengedokuto treated rats (150 mg/kg/day) which showed a decrease in serum lipid peroxide ( p <0.001) and an increase in acid soluble glycoprotein ( p <0.001). In the case of adjuvant-induced arthritic rats, however, the condition of the arthritis was not
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5

Amoghimath, Siddamma, Suresha R. N., and Jayanthi M. K. "To evaluate the anti-inflammatory activity of ramipril in albino rats." International Journal of Basic & Clinical Pharmacology 7, no. 1 (2017): 16. http://dx.doi.org/10.18203/2319-2003.ijbcp20175485.

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Background: Angiotensin II (Ang II) is a product of Renin angiotensin aldosterone system (RAAS). Angiotensin‑II regulates vascular tone, stimulates the release of pro‑inflammatory cytokines, activates nuclear factor‑kappa B (NF‑κB), increases oxidant stress and functions as an inflammatory molecule. Ramipril an ACE inhibitor act by inhibiting angiotensin converting enzyme, decreases angiotensinogen II activity. Hence the present was to evaluate the anti-inflammatory activity of Ramipril.Methods: Eighteen Wistar albino rats weighing around 150-200gms of either sex were randomly selected from ce
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Maxia, Andrea, Maria Assunta Frau, Danilo Falconieri, Manvendra Singh Karchuli та Sanjay Kasture. "Essential Oil of Myrtus communis Inhibits Inflammation in Rats by Reducing Serum IL-6 and TNF-α". Natural Product Communications 6, № 10 (2011): 1934578X1100601. http://dx.doi.org/10.1177/1934578x1100601034.

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The topical anti-inflammatory activity of the essential oil of Myrtus communis L. was studied using croton oil induced ear edema and myeloperoxidase (MPO) activity in mice, and cotton pellet induced granuloma, and serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in rats. On topical application, the oil exhibited a significant decrease in the ear edema as well as MPO activity. The oil also inhibited cotton pellet-induced granuloma and serum TNF-α and IL-6. It can be concluded that the essential oil of Myrtus communis reduces leukocyte migration to the damaged tissue and exhibits a
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7

Afreen, Adiba, Shaik Mohd Khasim, Sayeda Umme Bathool, and Fouzia Tehseen. "Evaluation of Anti-inflammatory activity of Jacquemontia caerulea Leaf Methanolic Extract in Wistar rats." Journal of American Medical Science and Research 3, no. 1 (2024): 1–5. http://dx.doi.org/10.51470/amsr.2024.03.01.01.

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Objective: To evaluate anti-inflammatory activity of methanolic extract of obtained from the leaves of plant, Jacquemontia caerulea in Wistar rats. Methods: Fresh leaves of Jacquemontia caerulea (Family: Convolvulaceae) were extracted using methanol and subjected to phytochemical analysis using standard procedures. The anti-inflammatory nature of the methanolic leaf extract (JCLME) was assessed on Wistar rats, with Indomethacin serving as the standard reference drug. Two established methods were employed: Paw edema method by using Carrageenan and Cotton pellet granuloma method. Results: Phytoc
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8

Khan, N. I., and B. C. Hatapakki. "Anti-Inflammatory Activity of Mimosa hamata (Willd.)." Journal of Drug Delivery and Therapeutics 9, no. 5-s (2019): 34–39. http://dx.doi.org/10.22270/jddt.v9i5-s.3596.

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Anti-inflammatory activity of ethanolic extract of roots, stems and leaves Mimosa hamata was investigated at the doses of 200 and 400 mg/kg using carrageenan induced paw edema and cotton pellet granuloma technique in albino rats. The stem extracts showed significant activity in dose dependent manner as compared to control group. The observations suggested that the extract of M. hamata were effective in exudative and proliferative phases of inflammation i.e. in acute and chronic inflammation. The results obtained indicate that M. hamata has an anti-inflammatory activity that supports the folk m
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9

Sultana, Afroza, Rumana Afroz, Onayza Yasmeen, Muqbula Tasrin Aktar, and Md Abdullah Yusuf. "Anti-Inflammatory Effect of Ethanolic Extract of Carica Papaya Leaves and Indomethacin in Cotton Pellet Induced Granuloma in Animal Model." Journal of Current and Advance Medical Research 6, no. 1 (2019): 2–5. http://dx.doi.org/10.3329/jcamr.v6i1.40773.

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Background: Anti-inflammatory effect can be exerted by Carica papaya.
 Objective: The purpose of the present study was to see the anti-inflammatory effect of ethanolic extract of Carica papaya leaves and indomethacin in carrageenan induced rat paw edema animal model.
 Methodology: This was an animal study carried out in the Department of Pharmacology at Dhaka Medical College, Dhaka, Bangladesh during the period from July 2014 to June 2015 for a period of one (01) year. The leaves of Carica Papaya collected from Botanical garden, Mirpur, Dhaka, Bangladesh. The animals were divided int
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10

Uzkeser, Hulya, Elif Cadirci, Zekai Halici, et al. "Anti-Inflammatory and Antinociceptive Effects of Salbutamol on Acute and Chronic Models of Inflammation in Rats: Involvement of an Antioxidant Mechanism." Mediators of Inflammation 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/438912.

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The possible role ofβ-2 adrenergic receptors in modulation of inflammatory and nociceptive conditions suggests that theβ-2 adrenergic receptor agonist, salbutamol, may have beneficial anti-inflammatory and analgesic effects. Therefore, in this study, we induced inflammatory and nociceptive responses with carrageenan-induced paw edema or cotton-pellet-induced granuloma models, both of which result in oxidative stress. We hypothesized that salbutamol would prevent inflammatory and nociceptive responses by stimulatingβ-2 adrenergic receptors and the prevention of generation of ROS during the acut
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11

Tripathi, A., S. Mishra, A. Bist, et al. "A Study of Anti-inflammatory Activity of Nigella Sativa in Experimental Models of Acute & Subacute Inflammation." International Journal of Pharmaceutical and Clinical Research 14, no. 5 (2022): 96–104. https://doi.org/10.5281/zenodo.13824792.

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<strong>Aims and objectives:</strong>&nbsp;To evaluate antiinflammatory activity of Nigella sativa seeds in acute &amp; sub-acute models of inflammation in rats &amp; to compare it with control &amp; indomethacin.&nbsp;<strong>Materials &amp; Methods:</strong>&nbsp;Male wistar rats of weight 100-150 gram were used in the study. Ethanolic extract of N.sativa was used to evaluate antiinflammatory activity by carrageenan induced hind paw edema, kaolin induced paw edema &amp; cotton pellet granuloma by oral gavage method. Institutional Ethical Committee approval was taken before start of study.&nb
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12

Owoyele, BV, AIR Abioye, AL Oyewole, MO Ameen, IO Owemidu, and MO Adewusi. "Effects of the Ethanolic Extract of Bulbostylis coleotricha (Hochst.Exa. Rich.) on Inflammation in Adult Wistar Rats." Nigerian Journal of Natural Products and Medicine 19 (August 31, 2015): 101–5. http://dx.doi.org/10.4314/njnpm.v19i0.11.

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Bulbostylis coleotricha (family Cyperaceae) is a stem-tufted plant found in tropical region of Africa. It is locally used in treating various ailments among the African folks. Despite the high esteem this plant is held in Africa, there is dearth of scientific studies on B. coleotricha. This, in addition to the alarming increase in inflammatory diseases around the world, makes the present study to focus on the effect of the B. coleotricha extract on laboratory induced inflammation. Twenty-five adult Wistar rats, weighing between 225-287g were used for this experiment, and were randomly divided
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13

Y. R., Rajashekar, and Shobha S. N. "Variable potentiation of analgesic anti- inflammatory activity of diclofenac by two medicinal plants rubia cordifolia and cassia fistula in wistar albino rats." International Journal of Basic & Clinical Pharmacology 6, no. 4 (2017): 746. http://dx.doi.org/10.18203/2319-2003.ijbcp20170942.

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Background: NSAIDS are commonly prescribed drugs in clinical practice. However, their usage is limited by their toxicity profile and research continues for an alternative therapy with higher efficacy and safety. Various plant preparations found to be safe and effective are emerging, but their interactions with synthetic drugs are not much known.Methods: Wistar rats were divided in to four groups of six animals each Rubia cordifolia (RC) root preparation and casissia fistula (CF) leaf preparation were studied with sub anti-inflammatory dose of diclofenac in various analgesic, acute and subacute
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14

Ansari, M. M., and N. A. Khan. "Evaluation of Anti-inflammatory activity of Qurs-e-Mafasil Jadeed." Indian Journal of Pharmaceutical and Biological Research 2, no. 02 (2014): 27–33. http://dx.doi.org/10.30750/ijpbr.2.2.6.

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With an increased incidence of drug toxicity and resistance to allopathic drugs, plant drug formulations could be an interesting alternative. Some plant drugs and phytochemicals are known to be anti-inflammatory properties, and can be of great significance in treatment of inflammatory disorders. These considerations require the scientific evaluation of the most important and commonly used traditional herbal formulations. A study has been done to find anti-inflammatory activity of Qurs-e-Mafasil Jadeed containing Colchicun luteum, Curcuma longa and gum of Acacia Arabica. In this proposed work 2
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15

Morsy, Mohamed A., Snehal S. Patel, Azza A. K. El-Sheikh, et al. "Computational and Biological Comparisons of Plant Steroids as Modulators of Inflammation through Interacting with Glucocorticoid Receptor." Mediators of Inflammation 2019 (May 27, 2019): 1–9. http://dx.doi.org/10.1155/2019/3041438.

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Despite the usefulness of glucocorticoids, they may cause hazardous side effects that limit their use. Searching for compounds that are as equally efficient as glucocorticoids, but with less side effects, the current study compared plant steroids, namely, glycyrrhetinic acid, guggulsterone, boswellic acid, withaferin A, and diosgenin with the classical glucocorticoid, fluticasone. This was approached both in silico using molecular docking against glucocorticoid receptor (GR) and in vivo in two different animal models. All tested compounds interacted with GR, but only boswellic acid and withafe
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16

R, Chandrashekar, Manohar V.R, and Mohandas Rai. "Sub-acute anti-inflammatory activity of ethanolic extract of leaves of Leucas indica in Wistar albino rats." Journal of Scientific and Innovative Research 4, no. 1 (2015): 13–16. http://dx.doi.org/10.31254/jsir.2015.4104.

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Newer anti-inflammatory drugs are still under intense investigation, especially from herbs. Ethanolic extract of leaves of Leucas indica could be used to treat sub-acute inflammatory conditions. The objective of the study was to evaluate sub-acute anti-inflammatory activity of ethanolic extract of the leaves of Leucas indica in Wistar albino rats. Ten Wistar albino rats were randomly assigned to five groups as Controls, standard and three doses of the test drug viz 75, 150 &amp; 300 mg/kg, orally respectively. The adsorbent sterilized cotton pellet (20±1 mg) was implanted subcutaneously. Drugs
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17

Yoshida, Kazuo, Hiromi Mizukawa, Akie Honmura, et al. "The Effect of Sho-saiko-to on the Concentration of Acid Soluble Glycoprotein in Serum and on Granuloma Formation in Carrageenin Cotton Pellet-induced Granuloma Rats." American Journal of Chinese Medicine 21, no. 02 (1993): 171–77. http://dx.doi.org/10.1142/s0192415x93000200.

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The effect of Sho-saiko-to on the concentration of acid soluble glycoprotein in serum and on the granuloma formation in carrageenin cotton pellet-induced rats was investigated. As a result, a significant negative correlation between the concentration of acid soluble glycoprotein and granuloma weight was observed. Furthermore, both the concentration of acid soluble glycoprotein and the inhibition rate of the granuloma formation were significantly higher in the Sho-saiko-to group than in the control group. These results suggest that acid soluble glycoprotein plays an important role in promoting
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18

Naveen B, RajaSheker K, Anil Kumar A, and Abhilash G. "Inflammation lowering property of pistacia atlantica in cotton pellet granuloma." International Journal of Review in Life Sciences 9, no. 2 (2019): 14–17. http://dx.doi.org/10.26452/ijrls.v9i2.1329.

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There are few defence mechanisms by which the body identifies and recovers from any physical injuries or external damage-causing stress and stimuli. This is through inflammation wherein the pain and the healing enzymes release into the bloodstream and cause pain and swelling that causes protection from those damages. The most important of the causative factors of the inflammation is the oxidative damage and the physiological stress. There were investigations on the herbs that were used in the treatment of diseases and were claimed to contain very limited or without side effects. Thus, they gai
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19

Safwan Ali Khan, Mohammed, Nishath Khatoon, Mohammad M. Al-Sanea, Mohamed Gamal Mahmoud, and Hidayat Ur Rahman. "Methanolic Extract of Leathery Murdah, Terminalia coriacea (Roxb.) Wight and Arn. Leaves Exhibits Anti-Inflammatory Activity in Acute and Chronic Models." Medical Principles and Practice 27, no. 3 (2018): 267–71. http://dx.doi.org/10.1159/000488199.

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Objective: The aim of the present study was to evaluate anti-inflammatory activity of methanolic extract of Terminalia coriacea. Materials and Methods: A methanolic extract of T. coriacea leaves was studied in albino Wistar rats with carrageenan-induced paw edema, an acute model, and cotton pellet-induced granuloma, a chronic model, at 3 oral test doses (125, 250, and 500 mg/kg). Aspirin 100 mg/kg was used as a positive control. Paw volume and wet and dry weights of cotton pellets were determined. The data were analyzed by one-way ANOVA followed by Dunnett’s multiple comparison test. Results:
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Yoshida, Kazuo, Hiromi Mizukawa, Akie Honmura, Yasuhiko Uchiyama, Shigekatsu Nakajima, and Eiichi Haruki. "The Effect of Sho-saiko-to on Concentration of Vitamin E in Serum and on Granuloma Formation in Carrageenin Cotton Pellet-Induced Granuloma Rats." American Journal of Chinese Medicine 22, no. 02 (1994): 183–89. http://dx.doi.org/10.1142/s0192415x9400022x.

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The effect of Sho-saiko-to on the concentration of vitamin E in serum and on the granuloma formation in Carrageenin cotton pellet-induced rats was investigated. As a result, in the granuloma rats of Sho-saiko-to group, a significantly improved inhibitory effect on granuloma formation and a higher concentration of vitamin E in serum, cholesterol and phospholipid were observed compared to the control group. Despite this lipid-increasing action by Sho-saiko-to, the concentration of serum lipid peroxide was significantly lower than in the control group. Furthermore, a significant negative correlat
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21

Sireeratawong, Seewaboon, Arunporn Itharat, Nusiri Lerdvuthisopon, et al. "Anti-Inflammatory, Analgesic, and Antipyretic Activities of the Ethanol Extract of Piper interruptum Opiz. and Piper chaba Linn." ISRN Pharmacology 2012 (March 18, 2012): 1–6. http://dx.doi.org/10.5402/2012/480265.

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Piper interruptum Opiz. and Piper chaba Linn. are herbaceous plants in the Piperaceae family. The ethanol extract of P. interruptum and P. chaba inhibited ethyl phenylpropiolate-induced ear edema and carrageenan-induced hind paw edema in rats. Both extracts reduced transudative and granuloma weights as well as body weight gain and thymus weight of the chronic inflammatory model using cotton pellet-induced granuloma formation in rats. Moreover, both extracts exhibited analgesic activity on both early phase and late phase of formalin test in mice and also showed antipyretic activity on yeast-ind
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22

Anil kumar, K. V., J. Samhitha, and T. Rama. "ANTI-INFLAMMATORY POTENTIAL OF FLEMINGIA STROBILIFERA R.BR . ROOTS: AN EXPERIMENTAL STUDY IN RAT MODELS." INDIAN DRUGS 57, no. 10 (2021): 58–64. http://dx.doi.org/10.53879/id.57.10.12446.

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Flemingia strobilifera R.Br. (Fabaceae), is a perennial plant traditionally used as an indigenous medicine for its pharmacological characteristics. The goal of our experimentation was to study the chloroform extract of F. strobilifera roots for its anti-inflammatory potential through anti-inflammatory models like carrageenan - elicited rat hind paw edema , cotton pellet - elicited granuloma formation, and carrageenan - elicited leucocyte to justify ethno-medicinal use of the plant. Indomethacin, a reference drug, was used to compare anti-inflammatory potential. The extract, administered respec
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23

Sireeratawong, Seewaboon, Kanjana Jaijoy, Parirat Khonsung, and Noppamas Soonthornchareonnon. "ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF THE WATER EXTRACT FROM TERMINALIA CHEBULA REZT." African Journal of Traditional, Complementary and Alternative Medicines 11, no. 6 (2014): 77–82. http://dx.doi.org/10.21010/ajtcam.v11i6.8.

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Background: In ayurvedic and Thai traditional medicine, the fruit of T. chebula is useful in arthritic disorders, inflammation, tumor, pains, chronic and recurrent fever. The study investigated the analgesic and anti-inflammatory activities in animal models.&#x0D; Materials and methods: The water extract of T. chebula fruit was prepared and pain induced in mice by 0.1% formalin, before testing for the analgesic activity of the extract. The anti-inflammatory study was conducted in rats using four experimental models; ethyl phenylpropiolate or arachidonic acid-induced ear edema, carrageenan-indu
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Thanh, Mai Phuong, Ho My Dung, Le Anh Tuan, et al. "Anti-inflammatory effects of the extracts from Ardisia silvestris Pitard leaves in experiment." Tạp chí Nghiên cứu Y học 190, no. 5E16 (2025): 188–95. https://doi.org/10.52852/tcncyh.v190i5e16.3279.

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This research aimed to explore the anti-inflammatory effects of n-hexane, ethyl acetate (EtOAc), and n-butanol extracts from the leaves of Ardisia silvestris Pitard, both in vitro and in vivo, specifically focusing on the EtOAc extract. The in vitro assessment of anti-inflammatory activity involved measuring the inhibition of nitric oxide (NO) production in LPS-stimulated RAW 264.7 macrophage cells. The findings revealed that the EtOAc extract exhibited the highest potency, with an IC50 value of 52.10 ± 2.07 µg/mL, effectively inhibiting NO production without causing cellular damage. In vivo,
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Jamila. A Omale, Lawrence US Ezeanyika, Bennett C Nwanguma, and Aminu Omale. "Effect of dietary omega-3-polyunsaturated fatty acid in animal models of experimentally-induced granulomatous inflammatio." Magna Scientia Advanced Biology and Pharmacy 8, no. 2 (2023): 013–18. http://dx.doi.org/10.30574/msabp.2023.8.2.0022.

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Recent advances have shown how polyunsaturated fatty acids (PUFAs) regulate molecular signaling, especially in the context of inflammation. Nutritional intervention/ supplementation with PUFAs in experimental animal models have exhibited anti-inflammatory properties. In this study, chronic inflammation was assayed by cotton pellet-induced granuloma method to evaluate the anti-inflammatory and anti-granuloma effects of omega-3-polyunsaturated fatty acid using experimentally induced inflammatory models in rats. Obtained results indicate that omega-3 oil extract significantly (p&lt;0.05) reduced
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Aldeen Ahmed Naji Ismail, Salah, Riaz Mahmood, and Haseebur Rahman. "Evaluation of the anti-inflammatory potential of Solanum pubescens fruit extract." Biomedicine 43, no. 02 (2023): 674–83. http://dx.doi.org/10.51248/.v43i02.2687.

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Introduction and Aim: Solanum pubescens is one of the very well-known traditional medicinal plants it has been widely used in the treatment of many inflammatory conditions. This study aimed to evaluate the anti-inflammatory property of S. pubescens fruit. Materials and Methods: Anti-inflammatory activities of S. pubescens fruit extracts at different concentrations (100-200 mg/kg) were carried out using carrageenan-induced and cotton implant-induced granuloma methods. Results: The results of the carrageenan-induced paw edema study reveals the highest activity of fruit upper ethanolic (FUEE) ext
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Wu, Hung-Tsung, Cheng Kuei Chang, Chiung-Wen Tsao, et al. "Insulin resistance without obesity induced by cotton pellet granuloma in mice." Laboratory Investigation 89, no. 3 (2009): 362–69. http://dx.doi.org/10.1038/labinvest.2008.161.

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Nikhila, Mary George P.1* Bindu A. R.2. "Anti-Inflammatory Activity Of Canthium Angustifolium Roxb Leaves By Carrageenan Induced Paw Oedema And Cotton Pellet Granuloma Method." International Journal in Pharmaceutical Sciences 2, no. 4 (2024): 688–93. https://doi.org/10.5281/zenodo.10964781.

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The total ethanolic extract of Canthium angustifolium Roxb leaves screened for anti- inflammatory activity by carrageenan induced paw odema and cotton pellet granuloma. Anti-inflammatory activity of the leaf extract of Canthium angustifolium Roxb at a dose of 200mg/kg &amp; 400mg/kg was evaluated against the standard drug, diclofenac sodium. The higher dose of the extract (400 mg/kg) exhibited the anti-inflammatory effect better than the effect of the lower dose of the extract (200 mg/kg). In the present study, administration of C. angustifolium Roxb extract (200 mg/kg and 400 mg/kg, p.o.) was
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Al Amin, Md, Ishtiaque A. Chowdhury, KMM Mahbub, et al. "Anti-inflammatory and Analgesic Activities of Asteracantha longifolia Nees." Bangladesh Pharmaceutical Journal 15, no. 2 (2012): 171–76. http://dx.doi.org/10.3329/bpj.v15i2.12586.

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The present study was designed to evaluate the analgesic and anti-inflammatory activities of the ethanol extract of whole plant of Asteracantha longifolia Nees (family Acanthaceae) in mice. The analgesic activity was determined for its central and peripheral pharmacological actions using hotplate, formalin induced pain and acetic acid-induced writhing test in mice. Anti inflammatory effects were determined by ear swelling induced by croton oil, xyleneinduced ear edema, leukocyte migration induced by carrageenan, cotton pellet-induced granuloma formation. Tramadol (10 mg/kg) and Ibuprofen (100
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Hasan, Md Mahadi, Nizam Uddin, Md Rakib Hasan, et al. "Analgesic and Anti-Inflammatory Activities of Leaf Extract ofMallotus repandus(Willd.) Muell. Arg." BioMed Research International 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/539807.

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In folk medicineMallotus repandus(Willd.) Muell. Arg. is used to treat muscle pain, itching, fever, rheumatic arthritis, snake bite, hepatitis, and liver cirrhosis. This study aimed to evaluate the antinociceptive as well as the anti-inflammatory activities of the methanol extract of leaf. The leaves were extracted with methanol following hot extraction and tested for the presence of phytochemical constituents. Analgesic and anti-inflammatory activities were evaluated using acetic acid induced writhing test, xylene induced ear edema, cotton pellet induced granuloma, and tail immersion methods
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31

Wu, Xiao-Li, Chu-Wen Li, Hai-Ming Chen, et al. "Anti-Inflammatory Effect of Supercritical-Carbon Dioxide Fluid Extract from Flowers and Buds ofChrysanthemum indicumLinnén." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–13. http://dx.doi.org/10.1155/2013/413237.

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The aim of this study was to analyze the chemical composition and investigate the anti-inflammatory property of the supercritical-carbon dioxide extract from flowers and buds ofC. indicum(CISCFE). The anti-inflammatory effect was evaluated in four animal models including xylene-induced mouse ear edema, acetic acid-induced mouse vascular permeability, carrageenan-induced mouse hind paw edema, and cotton pellet-induced rat granuloma formation. The results indicated that CISCFEsignificantly attenuated xylene-induced ear edema, decreased acetic acid-induced capillary permeability, reduced carragee
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Bagad, Ashish Subhash, Joshua Allan Joseph, Natarajan Bhaskaran, and Amit Agarwal. "Comparative Evaluation of Anti-Inflammatory Activity of Curcuminoids, Turmerones, and Aqueous Extract ofCurcuma longa." Advances in Pharmacological Sciences 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/805756.

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Curcuma longais widely known for its anti-inflammatory activity in traditional system of medicine for centuries and has been scientifically validated extensively. The present study was conducted to evaluate the anti-inflammatory activity of curcuminoids and oil-free aqueous extract (COFAE) ofC. longaand compare it with that of curcuminoids and turmerones (volatile oil), the bioactive components ofC. longathat are proven for the anti-inflammatory potential. The activity against inflammation was evaluated in xylene-induced ear edema, cotton pellet granuloma models in albino Swiss mice and albino
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B. N., Priya Mohan, Suma Jayaram, and Sanitha Kuriachan. "Study of anti-inflammatory activity of Ficus racemosa linn stem bark extract in albino rats." International Journal of Basic & Clinical Pharmacology 10, no. 3 (2021): 231. http://dx.doi.org/10.18203/2319-2003.ijbcp20210552.

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Background: Inflammation is part of the complex biological response of vascular tissues to harmful stimuli. Though there are standard anti-inflammatory drugs like aspirin, diclofenac, etc., these are not free of side effects. This has led to an increase in demand for natural products with anti-inflammatory activity having less side effects. Hence the study was conducted to evaluate the anti-inflammatory activity of ethanolic extract of Ficus racemose (EEFR) in albino rats.Methods: Healthy albino rats of either sex were divided into 4 groups of 6 animals each. Group1-control, group 2-diclofenac
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34

Mian, Syed Shariq, Tajuddin Tajuddin, and Sukirti Upadhyay. "Anti-Arthritic Evaluation of Ginger, Colchicum and Detoxified Nux-Vomica combination for Poly Herbal Unani Formulation." Biomedical and Pharmacology Journal 14, no. 3 (2021): 1219–29. http://dx.doi.org/10.13005/bpj/2224.

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Introduction: Arthritis (Wajaul Mafasil) is a condition which is growing worldwide due to lifestyle, environmental and genetic factors. In Unani literature, there are many herbs which are praised for treatment of Arthritis. So polyherbal formulation contains Ginger, Colchicum and Nux- Vomica is taken in combination for arthritis study. This combination is not previously reported but used by unani practitioners. Method: Three crude herbs (Ginger, Colchicum and Nux vomica) were extracted out in both aqueous and hydro-alcoholic solvent. LD-50 of all extracts (aqueous and hydro-alcoholic extract)
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35

Olorukooba, Amina Busola, Aishatu Shehu, Ferhat Khan, Asmau Hamza Nasir, Aisha Oiza Musa, and Munir Ari Sani. "Anti-Inflammatory Potential of Methanol Leaf Extract of Senna italica (Mill.) Using Cotton Pellet-induced Granuloma Model in Wistar Rats." Journal of Current Biomedical Research 2, no. 3, May-June (2022): 209–23. http://dx.doi.org/10.54117/jcbr.v2i3.24.

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Senna italica Mill. belonging to the family Fabaceae has been used traditionally to treat various ailments diseases including skin diseases, fever, jaundice, stomachache, burns and inflammation. The aim of the present study was to evaluate the phytochemical profile and the anti-inflammatory activity of the methanol leaf extract of the plant. Preliminary phytochemical screening and oral acute toxicity studies were carried out using standard protocols. Anti-inflammatory activity was investigated in Wistar rats using cotton pellet-induced granuloma model at doses of 250, 500 and 1000 mg/kg. Hemat
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36

Parveen, S., and Z. A. Begum. "The Effect of Niella sativa Linn. Ground Seed Extract on Cotton Pellet Induced Inflammation in Rats." Journal of Medical Science & Research 15, Number 2 (2010): 19–23. http://dx.doi.org/10.47648/jmsr.2010.v1502.04.

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The study was done to find out the anti-inflammatory effects of the ethanolic extract of ground seeds of Nigella swim in inflammed rats. The effect was compared with reference standard drugs aspirin and hydrocortisone. Chronic it was induced by implantation of a sterile cotton pellet in rut's groin region. Treatment with Nigella saliva extract at a dose of 250 mg/kg body weight and at a dose of 500 mg/kg body weight orally daily for 14 days produced anti-inflammatory effect. The percentage of inhibition of granuloma formation were 19.30% and 41.42% respectively. Administration of aspirin and h
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37

Y. R., Rajashekar, and Narasimhamurthy K. M. "A comparative evaluation of analgesic and anti-inflammatory activities of two medicinal plants rubia cordifolia and cassia fistula in wistar albino rats." International Journal of Basic & Clinical Pharmacology 6, no. 4 (2017): 802. http://dx.doi.org/10.18203/2319-2003.ijbcp20170939.

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Background: Pain and inflammation are disabling accompaniments of many medical conditions. So, controlling both pain and inflammation assumes the top priority for the physician. Inflammation is a part of a complex biological response of vascular tissues to harmful stimuli such as pathogens, chemicals or irritants. Therapy of pain and inflammation has always been debatable.Methods: Rats were divided into 8 groups of 6 animals of each. The anti-inflammatory activity was studied with carrageenan induced rat paw edema and cotton pellet induced granuloma models. The analgesic activity was evaluated
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Solapure, Poornima, Pradeep, Ravi Mundugaru, and Prakash L. Hegde. "Comparative anti-inflammatory activity of Clerodendrum serratum (Linn) Moon and Solanum xanthocarpum Schrad and Wendl in wistar ablino rats." Journal of Phytopharmacology 5, no. 2 (2016): 38–44. http://dx.doi.org/10.31254/phyto.2016.5201.

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C. serratum and S. xanthocarpum plants are used as folk remedies for inflammations, arthritis, cough, asthma and bronchitis. The present investigation aimed to evaluate the comparative anti-inflammatory activity in Wistar albino rats. The group specific rats were treated for seven consecutive days and subjected to carrageenan induced paw oedema and cotton pellet implanted granuloma tissue formation tests at a dose of 8.64ml/kg (p.o). Both the test drugs have shown reduced paw volume during third and sixth hour readings and a moderate decrease in the granuloma tissue formation. CRP enzyme was f
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Vivek Chourasia, Tanmay Patwardhan, Pankaj Tiwari, and Reetesh Yadav. "Research Paper Evaluation of Anti-Inflammatory Activity of Cassia Angustifolia Seeds Extract in Rat." Journal of Advanced Zoology 44, no. 4 (2023): 1092–99. http://dx.doi.org/10.17762/jaz.v44i4.2518.

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The present study was designed to perform evaluate antiinflamatory activity of seeds of Cassia angustifolia. Seed of Cassia angustifolia was extracted using methanol as solvent by soxhlet apparatus. The evaluation of antiinflamatory activity was done using carrageenan induced rat paw edema assay. The work entitled evaluation of antiinflamatory activity of seeds of Cassia angustifolia was to determine the efficacy and safety in experimental animals. Both aqueous and methanolic extract of seeds of Cassia angustifolia have shown significant reduction in inflamation in proliferative phase as indic
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Ahmed Azad Kareem, Tavga Ahmed Aziz, Zheen Aorahman Ahmed, Hemn Hassan Othman, and Saad Abdulrahman Hussain. "Anti-Inflammatory Activity of Gingko Biloba Extract in Cotton Pellet-Induced Granuloma in Rats: A comparative Study with Prednisolone and Dexamethasone." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 31, no. 1 (2022): 184–93. http://dx.doi.org/10.31351/vol31iss1pp184-193.

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The current study was designed to evaluate the anti-inflammatory effect of GKB in the rat model of granulomatous inflammation. Thirty rats were distributed into five groups: The first group served as negative control group that received distilled water (DW) only without inducting inflammation, positive control group; treated with DW with the induction of inflammation and they were assigned to cotton pellet-induced granuloma, ginkgo biloba (GKB) treated group (200mg/kg/day), dexamethasone-treated group (1mg/kg), and Prednisolone treated group (5mg/kg). All the treatments were given orally for s
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Kudaravalli, Sreedevi 1. *. Jangala Venkateswara Rao 2. "EVALUATION OF ACUTE AND CHRONIC ANTI-INFLAMMATORY ACTIVITY IN ETHANOLIC EXTRACT OF AERIAL PARTS OF CARDIOSPERMUM HALICACABUM AND CARDIOSPERMUM CANESCENS IN ANIMAL MODELS." Journal of Scientific Research in Pharmacy 6, no. 12 (2017): 179–84. https://doi.org/10.5281/zenodo.1419589.

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<strong><em>ABSTRACT</em></strong> <strong><em>T</em></strong><em>he present study investigates the zcute and chronic&nbsp; anti-inflammatory activity in ethanolic extract of aerial parts of Cardiospermum halicacabum and Cardiospermum canescens&nbsp; L using carrageenan, Acetic acid, Xylene , PMA induced edema in animals significantly swelling inhibited ***P&lt;0.001 when compared to control group P&lt;0.001when compared to test ethanolic extract dose 250mg, 500mgP&lt;0.001 when compared to stabdard drug.And inchronic inflammatory&nbsp; study revealed that treatment of rats with both the extra
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Pauna, Ana-Maria Raluca, Liliana Mititelu Tartau, Alin Mihai Vasilescu, et al. "Assessment of the Anti-Inflammatory Effectiveness of Diclofenac Encapsulated in Chitosan-Coated Lipid Microvesicles in Rats." Pharmaceutics 17, no. 5 (2025): 607. https://doi.org/10.3390/pharmaceutics17050607.

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Background: Diclofenac (DCF) is a widely used nonsteroidal anti-inflammatory drug (NSAID), but its conventional formulations may have limited efficacy and are associated with adverse effects. This study aimed to evaluate the anti-inflammatory and antioxidant effects of diclofenac encapsulated in chitosan-coated lipid microvesicles (DCF-m) compared to free DCF in a rat model of subacute inflammation. Method: DCF-m was prepared using L-α-phosphatidylcholine and coated with chitosan (CHIT). Subacute inflammation was induced using the cotton pellet granuloma model, and animals were divided into fo
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Sokeng, Sélestin Dongmo, Emmanuel Talla, Paul Sakava, et al. "Anti-Inflammatory and Analgesic Effect of Arachic Acid Ethyl Ester Isolated from Propolis." BioMed Research International 2020 (May 5, 2020): 1–8. http://dx.doi.org/10.1155/2020/8797284.

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Inflammatory diseases are a real public health problem worldwide. Many synthetic drugs used in the treatment of inflammatory diseases such as steroidal anti-inflammatory drugs, nonsteroidal anti-inflammatory drugs (NSAIDs) and immunosuppressive drugs have harmful side effects. However, there are natural products like propolis, which is traditionally used in the treatment of pain. The objective of this work was to evaluate the anti-inflammatory and analgesic activities of the ethyl ester of arachic acid, a compound isolated from Cameroonian propolis. The ethyl ester of arachic acid was isolated
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44

Vipin, Vipin Kr Garg. "ANTI-INFLAMMATORY ACTIVITY OF SPINACIA OLERACEA." International Journal of Pharma Professional's Research 01, no. 01 (2010): 1–4. https://doi.org/10.5281/zenodo.10947989.

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The present study deals with the investigation of phytochemically evaluated ethanolic and aqueous extracts of leaves of Spinacia&nbsp; oleracea for its anti-inflammatory activity. The anti-inflammatory activity was evaluated by carrageenan induced rat paw oedema method for acute inflammation and cotton pellet granuloma method for chronic inflammation. The standard drug used was&nbsp; Indomethacin (20mg/kg) for both the models. In both methods, ethanolic as well as aqueous extract at a dose level of 1100mg/kg&nbsp; has shown significant activity which is comparable to that of the standard.
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N., Shiva Murthy, Srinivas V., and Shanthi M. "Anti-inflammatory and ulcerogenic activities of thiazolidine-4-ones in rats." International Journal of Basic & Clinical Pharmacology 8, no. 1 (2018): 8. http://dx.doi.org/10.18203/2319-2003.ijbcp20185155.

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Background: NSAIDS are associated with side effects and research should continue for developing safer drugs. This study aims to evaluate newer thiazolidine-4-ones for their anti-inflammatory and ulcerogenic activities in wister rats.Methods: Five groups of wister rats, 6 in each were used. Anti-inflammatory and ulcerogenic activities of diclofenac (30mg/kg), nimesulide (50mg/kg), thia-1 (50mg/kg) and thia-2 (50mg/kg) are compared with control group (4% Gum Acacia). Carrageenin-induced paw edema, formaline induced acute peritonitis and cotton pellet-induced granulomatous tissue formation models
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46

Li, Zhuocheng, Lei Zhang, and Zhichao Zhao. "Malyngamide F Possesses Anti-Inflammatory and Antinociceptive Activity in Rat Models of Inflammation." Pain Research and Management 2021 (June 18, 2021): 1–9. http://dx.doi.org/10.1155/2021/4919391.

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Objective. Inflammation and pain are involved in the pathophysiology of various clinical conditions. This investigation aims to probe the analgesic and anti-inflammatory activity of Maltoamide F. Methods. The possible toxicity of Maltoamide F was evaluated by an acute toxicity test. To assess the anti-inflammatory and antinociceptive effects of Maltoamide F on rats, the models of carrageenan-caused paw edema, xylene-induced ear edema, arachidonic-acid- (AA-) induced ear edema, formalin-caused plantar edema, and cotton-pellet-induced granuloma were established. Levels of TNF-α, PGE-2, and IL-6
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47

Omoyiola, Olajide Laide, Liasu Tolulope Ayomikun, Shabi Dolapo Rafiu, et al. "Anti-Inflammatory Property of Costus afer Ker Gawl Ethanol Leaf Extract in STZ-Induced Diabetic Rats." Scholars International Journal of Biochemistry 6, no. 10 (2023): 129–37. http://dx.doi.org/10.36348/sijb.2023.v06i10.002.

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Costus afer Ker Gawl is an indigenous plant, commonly called a ginger lily, spiral ginger, or bush cane, it has been reported to possess anti-inflammatory properties. The anti-inflammatory activity of C.afer leaf extract in streptozotocin-induced diabetic rats was investigated. Protein denaturation and erythrocyte stabilization assays were used to evaluate in vitro anti-inflammatory activity, and alpha-amylase and alpha-glucosidase enzyme inhibition was used to evaluate in vitro anti-diabetic activity. 60 male Wistar rats were used for the two inflammatory models: the 30 rats were randomly ass
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Subramaniyan, Vetriselvan, and Velmurugan Paramasivam. "POTENTIAL ANTI-INFLAMMATORY ACTIVITY OF PLUMBAGO ZEYLANICA." Asian Journal of Pharmaceutical and Clinical Research 10, no. 10 (2017): 372. http://dx.doi.org/10.22159/ajpcr.2017.v10i10.20357.

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Objective: To determine the anti-inflammatory activity of dichloromethane extract of Plumbago zeylanica (DMEPZ), and its possible mechanism of action.Methods: Male Wistar rats (180-200 g) under controlled standard conditions (24±1°C, 55-58 humidity and 12 hrs light/dark cycle). The groups were divided into 5 groups (n=6/group) and assigned as positive control, negative control, and standard and two different test dose groups of P. zeylanica. Paw edema induced by subplantar injection of 0.1 mL of carrageenan (suspended in 1% carboxymethyl cellulose) into the right hind paw in all groups except
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Adeyemi, Olufunmilayo O., Ismail O. Ishola, Elizabeth T. Adesanya, and Destiny O. Alohan. "Antinociceptive and anti-inflammatory properties of Tetracera alnifolia Willd. (Dilleniaceae) hydroethanolic leaf extract." Journal of Basic and Clinical Physiology and Pharmacology 30, no. 2 (2018): 173–84. http://dx.doi.org/10.1515/jbcpp-2016-0190.

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Abstract Background Tetracera alnifolia Willd. (Dilleniaceae) is used in traditional African Medicine for the treatment of headache, abdominal pain, and rheumatism. Hence, this study sought to investigate the antinociceptive and anti-inflammatory effects of the hydroethanolic leaf extract of T. alnifolia (HeTA) in rodents. Methods Antinociceptive activity was evaluated using the acetic acid-induced writhing, formalin-/capsaicin-induced paw licking and hot plate tests in mice. The contribution of opioidergic, l-arginine-nitric oxide, and ATP-sensitive potassium channel pathways in HeTA-induced
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Miri, Abdolhossein, Javad Sharifi-Rad, Kaveh Tabrizian, and Ali Akbar Nasiri. "Antinociceptive and Anti-Inflammatory Activities ofTeucrium persicumBoiss. Extract in Mice." Scientifica 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/972827.

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Background.Therapeutic properties ofTeucriumspecies as antioxidant, antibacterial, analgesic, anticancer, diuretic, and tonic compounds have been proved earlier.Materials and Methods. In this study, the antinociceptive and anti-inflammatory effects of the aqueous extract ofTeucrium persicumon chronic pain, sciatic nerve ligation as a model of neuropathic pain, and inflammatory models were investigated by formalin, hot-plate, and cotton pellet-induced granuloma models in mice, respectively.T. persicumaqueous extracts (100, 200, and 400 mg/kg) were orally gavaged for one week. On 8th day, the ti
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