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Journal articles on the topic 'Cough syrup'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Dipali, Chaudhari* Khushi Patil Jagruti Wankhede Saeed Ahmed Shaikh Habiburrahman. "A Comprehensive Review on The Formulation and Evaluation of Herbal Cough Syrup." International Journal of Pharmaceutical Sciences 3, no. 1 (2025): 1094–103. https://doi.org/10.5281/zenodo.14644399.

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The most common problem suffered by individuals everywhere over many centuries cough. Coughing is the protective mechanism of the body. Coughs are classified further accordingly which are depending upon factors such as signs and symptoms, duration, type, character, etc. Most commonly used, prepared and popular dosage form to cure cough and cold is syrup. The most preferred dosage form to cure cough is herbal syrup, which is used mostly due its benefits over synthetic syrups. Medicinal plants are used as primary health care agents, mostly in Asian countries. Ingredients showing expectorant anti

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Panda, Pratikeswar, and Arpita Sahu. "Formulation and Evaluation of Herbal Cough Syrup." Asian Journal of Pharmaceutical Research and Development 11, no. 2 (2023): 28–33. http://dx.doi.org/10.22270/ajprd.v11i2.1234.

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The most common problem suffered by individuals everywhere over many centuries is cough. Coughing is the protective mechanism of the body. Coughs are classified further accordingly which are depending upon factors such as signs and symptoms, duration, type, character, etc. Most commonly used, prepared and popular dosage form to cure cough and cold is syrup. The most preferred dosage form to cure cough is herbal syrup, which is used mostly due to its benefits over synthetic syrups. Medicinal plants are used as primary health care agents, mostly in Asian countries. Ingredients showing expectoran

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3

Pallavi, pandit* Aditi Pacharane Kanchan Pandit NIKUM R. D. "To Formulation and Evaluation of Herbal Cough Syrup." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 1234–41. https://doi.org/10.5281/zenodo.15364981.

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Gulvel syrup Guvel syrup is also known as immunity-boosting syrup. Gulvel syrup is a concoction of sugar, honey, and occasionally alcohol. The syrup was created by combining gulvel powder, tulsi, turmeric powder, and ginger cloves. The parameters used to evaluate cough syrup are density, color, odor, viscosity, stability, and pH. Cough syrups come in two varieties: wet cough and dry cough. Asthma, hypertension, fever, malaria, fungal, bacterial, and cardiac disorders are among the acute and chronic conditions that are treated using various plant components that contain biologically active ingr

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Kiran. P. Gaikwad, Priyanka S. Lande, Chanchal S. Chandak, Jaya P. Ambhore, Nikita A. Deshmukh, and Rucha M. Chopade. "Ban Cough Syrup 2022 Review." International Journal of Frontiers in Science and Technology Research 5, no. 1 (2023): 014–18. http://dx.doi.org/10.53294/ijfstr.2023.5.1.0069.

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The contamination of cough syrups manufactured in Haryana was recently reported. The four cough and cold syrups so contaminated as to be banned by the WHO are Promethazine Oral Solution, Kofexmalin Baby Cough Syrup, Makoff Baby Cough Syrup, and Magrip N Cold Syrup. India-made cough and cold syrups are "potentially linked with acute kidney injuries and 70 children`s deaths" and will be distributed in The Gambia in 2022. According to the WHO, diethylene glycol and ethylene glycol are toxic to humans when consumed and can be fatal. This incident includes the prevalent proportion of cases with neu

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Pankaj, Kumar, Mohan Mishra Anand, Kumar Prakash, et al. "Preparation And Evaluation of Syrup- A Review." Pharmaceutical and Chemical Journal 12, no. 2 (2025): 117–22. https://doi.org/10.5281/zenodo.15606787.

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Syrups are adaptable sweeteners that can be used to enhance the sweetness and richness of a variety of foods and drinks. They are available in a variety of tastes and forms. They give a range of flavours from straightforward sweetness to intricate fruit or nutty overtones, and they are essential in augmenting taste and texture. Most herbal syrup was originally derived from plant herbal medicine refers to use extract of fruit for medicinal purposes. Along with other dosage from herbal drugs also formulated inform of syrups. Today syrup is used for treatment of many ailments and to overcome symp

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A. Zagade, Krushna, Shaikh Usman M, Panchal Krushna S, Wavhale Sharda S, and Dr. R. D. Ingole. "Formulation and evaluation of polyherbal cough syrup." International Journal of Research in Pharmacy and Allied Science 04, no. 05 (2025): 76–91. https://doi.org/10.71431/ijrpas.2025.4508.

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Cough is a common health issue affecting people of all ages and is often treated using over-the-counter syrups. Most conventional cough syrups act by suppressing the brain’s cough reflex but can lead to side effects such as drowsiness, constipation, difficulty in breathing, addiction, and in some cases, death. Due to these risks, many people are turning to safer, natural alternatives. Ayurvedic medicine, which uses herbs and natural ingredients, is gaining popularity as a more suitable option for cough relief. Herbal cough syrups are especially favored because they are easy to consume and gene

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Sakshi, Patil Şanika Padawale* Samruddhi Patil Rutuja Pawar Prafull Patil. "Development and Assessment of Jaggery Based Herbal Cough Syrup Containing Clove." International Journal of Scientific Research and Technology 2, no. 4 (2025): 164–69. https://doi.org/10.5281/zenodo.15183441.

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One of the most widely used over-the-counter medications in the world is cough medicine. Recent research, however, indicates that there is little proof of the efficacy of many comparable treatments. For the treatment of colds and coughs, syrups are a popular and practical dose form. In this study, we created a herbal cough syrup using a foundation of peppermint oil, methyl paraben, and jaggery, as well as a decoction of medicinal herbs such ginger, tulsi, liquorice, black pepper, fennel, peppermint, and clove. The decoction process, which involves boiling the herbs to extract their active ingr

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Amaladoss, Alfred, and Simon O'Brien. "Cough Syrup Psychosis." CJEM 13, no. 01 (2011): 53–56. http://dx.doi.org/10.2310/8000.2011.100216.

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ABSTRACTOver-the-counter medications are widely accessible and used. Cough suppressant syrups contain dextromethorphan (DM), which has the potential to be abused, with resultant psychiatric symptoms. This case report describes a young woman presenting with psychotic mania secondary to DM abuse. We also describe the treatment of this toxidrome and include the results of a literature search on this topic. The recognition of cough syrup as an agent of abuse and its toxidrome is important. This will facilitate early diagnostic clarification and promote efficient treatment strategies.

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Ahmed, M. Khalique, Michael P. McLeod, Jean Nézivar, and Allison W. Giuliani. "Fourier transform infrared and near-infrared spectroscopic methods for the detection of toxic Diethylene Glycol (DEG) contaminant in glycerin based cough syrup." Spectroscopy 24, no. 6 (2010): 601–8. http://dx.doi.org/10.1155/2010/608749.

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Recently there have been reports of the contamination of cough syrups with Diethylene Glycol (DEG). The consumption of such cough syrups has devastating effects on the health. In this paper we report evidence that Fourier transform infrared (FT-IR) and near-infrared (NIR) spectroscopic techniques are viable, simple, cost effective, rapid and fool proof methods for the identification and quantification of DEG in glycerin based cough syrups. The FT-IR and NIR spectra of the glycerin based cough syrup and up to 50:50 mixtures of DEG in cough syrup are recorded. The major peaks in the FT-IR spectr

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Ghodk, Bhagyashree. "Formulation and Evaluation of Herbal Cough Syrup." International Journal for Research in Applied Science and Engineering Technology 13, no. 5 (2025): 7573–81. https://doi.org/10.22214/ijraset.2025.71939.

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An ancient time people use various plant, roots, and leaves for treatment various disease. Herbal cough syrup is an Ayurveda medicine which is useful in many chronic health problem such as cough, cold, fever, respiratory infection and disorders among human. As a combination of herbs, it is safe, can be made at home, has a low production cost, and can be easily available in any area. Herbal syrup including natural herbs, like tulsi, clove, fennel, turmeric and adulation which have various action and effects on reducing acute or chronic cough and cold and act as cough suppressant having expector

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Payal, Badhe* Gugale Vaishnavi. "The Herbal Hue: A Comprehensive Research on the Formulation and Evaluation of Natural Hair Dyes." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3788–98. https://doi.org/10.5281/zenodo.15489646.

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The main objective of this study was to eliminate harmful synthetic ingredient from herbal cough syrup. Formulation and substitute them with safe natural ingredient. Asthmatic patients are increasing day by day in India due to various environmental reasons. It is beneficial for people suffering from chest congestion. The study aim to formulate a pure herbal syrup and to evaluate and compare its physicochemical properties with the marketed synthetic and herbal syrup. There are wide range of synthetic cough syrup available in the market with different functions, but their synthetic cough syrup s

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Sanika, Kondhalkar*1 Vishal Madankar2 Anil Panchal3. "Formulation and Evaluation of Pineapple Based Herbal Cough Syrup." International Journal of Scientific Research and Technology 2, no. 5 (2025): 453–61. https://doi.org/10.5281/zenodo.15468902.

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The use of fruit extracts for therapeutic purposes is known as herbal medicine; most of the constituents in herbal syrup are derived primarily from plants. In addition to various natural medicine doses, syrup formulae are also offered. These days, syrup is used to treat the symptoms of a wide range of illnesses. Antioxidant syrups are used to treat cancer because the body produces free radicals due to oxidative reactions and other stressors. While the adulsa leaf extract serves as natural expectorant, the pineapple extract gives the orange peel syrup flavor. Alcohol and sugar are used as prese

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Osuntokun, Oludare Temitope, and Adekahunsi, Agnes Oluwasimbo. "Biohazards Signatures of Cough Syrup Isolates from Patent Medicine Shops, Akungba-Akoko Metropolis." Journal of e-Science Letters 5, no. 1 (2024): 7–19. https://doi.org/10.51470/esl.2024.5.1.07.

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The aim of this study is, to isolate, identify and characterize microbial analysis & biohazards signatures of cough syrup isolates from patent medicine shop in Akungba-Akoko metropolis and determined the antibiotics pattern of the isolates from cough syrup. Microbial bioharzard of cough syrup can occur at various stages of the manufacturing process, including raw material handling, storage, and packaging. Microorganisms such as bacteria, fungi, and viruses can survive and multiply in the cough syrup, leading its contamination. For this reason, this study was conducted to investigate the qu

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Jaybhaye, D. L., S. Chandra, S. Johar, and A. S. Nagre. "Effect of honey and ginger mixture on productive cough in pediatrics patients." International Journal of Basic & Clinical Pharmacology 11, no. 3 (2022): 237. http://dx.doi.org/10.18203/2319-2003.ijbcp20221038.

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Background: Cough is common problem in pediatric age. Most of the parents use over the counter drugs along with cough syrups. Most of the cough syrup causes drowsiness and sedation as an adverse effect. So considering this we use ginger and honey mixture for treatment of productive cough to see its effectiveness. In Ayurveda, it is used since ancient time and in Indian it is used for home remedy for treatment of cough.Methods: We selected patient attended pediatric outpatient department (OPD) complaining of productive cough. We selected 90 patients and divided in to three groups 30 patient in

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Bamise, Cornelius Tokunbo, Elizabeth Obhioneh Oziegbe, Esan Temitope Ayodeji, and Ireti Francis Alo. "Erosive potential: Laboratory evaluation of tooth dissolution in cough syrups." Journal of Research in Dentistry 2, no. 3 (2014): 208. http://dx.doi.org/10.19177/jrd.v2e32014208-214.

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AIM: To evaluate the associated weight loss of extracted teeth after immersed in cough syrups for a period of time so as to predict the erosive potential of the liquid medicines. MATERIAL AND METHODS: pHs of the medicines were measured at the start of the study. 25 extracted test teeth were weighed to 0.01 mg and assigned at random to each syrup under evaluation. The test medicines were placed in 10 mL screw-cap plastic containers and the test teeth were weighed after 7 days. RESULTS: 88 % of the medicines caused reduction in weights of the test teeth after seven days of immersion. Weight loss

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Yogeshwar, Ugalmugle* Priti Ambhore. "Formulation And Evaluation of Herbal Cough Syrup." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 1923–28. https://doi.org/10.5281/zenodo.15388007.

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The cough is one of the most common problems faced all people. There are mainly two type of cough, one is Dry cough and another one wet cough. Dry cough is no mucous secretion while in wet cough there is cough with mucous secretion. Syrup is commonly used and popular dosage form which is used to cure cough and cold, because it having easy to patient compliance. The herbal cough syrup was formulated using crude drugs as Marshmallow root (as a anti-irritant), Elderberry (as a anti-bacterial), Pineapple (as a anti-inflammatory) & Ivy (as a anti-viral). Quality of herbal cough syrup was evalua

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Edobor Peter Kenneth Imarenezor, Onolunosen Abel Abhadionmhen, Paula Paul Shinggu, Joyce Briska, Ochanya Susan George, and Sunday Danya. "Bacterial contamination of retailed syrups traded in Wukari, North East, Nigeria." International Journal of Biological and Pharmaceutical Sciences Archive 2, no. 1 (2021): 117–25. http://dx.doi.org/10.53771/ijbpsa.2021.2.1.0073.

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There is an increasing concern that syrups may contain pathogenic or non-pathogenic microbes that can pose as public health risk to patients. This research was to investigate the bacterial contamination of retailed syrups sold in Wukari. Eighteen (18) different brands of syrups were collected from different medicine stores in Wukari, North East Nigeria. These various brands of syrups were taken to the Microbiology Laboratory, Federal University Wukari for analysis using standard bacteriological techniques. The results show that syrups samples with contaminants included the M & B paracetamo

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Gurung, Krishna, and Mamita Khaling Rai. "Assessment of Microbial Qualities of Some Cough Syrups and Multivitamins Marketed in Pokhara, Nepal." Prithvi Academic Journal 4 (May 12, 2021): 1–6. http://dx.doi.org/10.3126/paj.v4i0.37004.

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Recently, the manufacturers of pharmaceuticals have improved the quality of non-sterile pharmaceuticals in such a way that such products contain only minimal bioburden. However, the production of sub-standard cough syrups and multivitamin syrups may cause non-therapeutic effect in patients, particularly in children. For this reason, this study was conducted to evaluate the microbiological quality of cough syrup and multivitamin syrups marketed in Pokhara, Nepal. Different brands of 15 cough syrups and 15 multivitamin syrups were collected from different vendors of Pokhara and the spread plate

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Wijayanti, Rina, Deden Mulya Prayoga, and Sugeng Priyatno. "Tingkat Pengetahuan, Persepsi dan Sikap Pasien terhadap Kehalalan Obat Batuk Sirup yang Mengandung Alkohol di Apotek Farmarindo Banyumas." Jurnal Sehat Mandiri 18, no. 2 (2023): 149–61. http://dx.doi.org/10.33761/jsm.v18i2.1228.

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Medicines are pharmaceutical products that play an important role in health. Medicine can reduce morbidity and improve a person's quality of life1. Alcohol is one of the substances that is forbidden by Allah SWT. One medicine that contains alcohol is cough syrup. Many patients do not know whether cough syrup is halal. Therefore, this study aims to determine and measure the level of knowledge, perceptions, and attitudes of patients regarding the halalness of cough syrup containing alcohol at the Farmarindo Banyumas Pharmacy. This research is descriptive research using a questionnaire with a sam

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Mohan J, Devkar, Shaikh Shahrukh S. M. Shahrukh S. M, Amol G. Jadhao, Miss Jayshri Sanap, and Prashant A. Patil. "Formulation and Evaluation of Herbal Syrup." Asian Journal of Pharmaceutical Research and Development 9, no. 3 (2021): 16–22. http://dx.doi.org/10.22270/ajprd.v9i3.955.

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The cough it is a most common problem are face by the all people. There are two types of cough one is the Dry cough and second is wet cough. The dry cough is a no mucous and secretion while in wet cough there is cough mucous or secretion. The syrup is most commonly used and popular dosage form there is used in cure the cough and cold because it having ease of patients compliance. The herbal cough syrup was formulated using crude drugs as Pudina&Tulsi or Cinnamon as a main ingredient along with Honey. Today syrup is used for treatment of May ailments and to overcome symptoms of disease. The

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J. Pandya, PhD, Dr Shridhar, Dr Chetan H. Savaliya, PhD, Dr Vaishnavi B. Shiravale, Pharm D, and Dr Dheeraj H. Nagore, PhD. "A Clinical Validation Of Efficacy And Safety Of Polyherbal Formulation For Symptomatic Relief Of Acute Non-Productive Cough And Throat Irritation." Journal of Respiratory Medicine and Research 10, no. 1 (2025): 1–11. https://doi.org/10.52338/jrmr.2025.4650.

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Introduction: Acute nonproductive cough, often caused by upper respiratory tract infections, is a very common and disturbing symptom. Conventional treatments often cause undesirable side effects, and existing herbal formulations lack sufficient efficacy data, highlighting the need for safer approaches. A randomized, controlled clinical study that compared efficacy of polyherbal syrup (GP/PROD/2021/004) versus marketed syrup for relief of acute nonproductive cough and throat irritation. Method: A randomized, parallel-group, multicentric, active-controlled clinical trial enrolled 65 participants

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Patil, Ankush Ganpat, Kaivalya Gajanan Mirajakar, Pranav Laxman Savekar, Chetana V. Bugadikattikar, and Somesh S. Shintre. "Formulation and Evaluation of Ginger Macerated Honey Base Herbal Cough Syrup." International Journal of Innovative Science and Research Technology 5, no. 6 (2020): 582–89. http://dx.doi.org/10.38124/ijisrt20jun334.

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Cough is one of the most common problem faced by all people. There are mainaly two types of cough one is dry cough and another one is wet cough. dry cough there is no mucous and secretion while in wet cough there is cough with mucous or secretion. Syrup is commonly used and popular dosage form which is used to cure cough and cold, because it having ease of patients compliance. Syrup contain Ginger macerated honey base and also Tulsi, liquorice, cardamom, fennel, adulsa, clove as an antitussive and expectorant. Quality of final herbal syrup was evaluated for pre formulation a post formulation p

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Qasemzadeh, Mohammad Javad, Hosein Sharifi, Mohammad Hamedanian, et al. "The Effect of Viola odorata Flower Syrup on the Cough of Children With Asthma." Journal of Evidence-Based Complementary & Alternative Medicine 20, no. 4 (2015): 287–91. http://dx.doi.org/10.1177/2156587215584862.

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This study aimed to investigate the effect of violet syrup on cough alleviation in children with intermittent asthma. In a parallel, double-blind, randomized controlled trial, 182 children aged 2 to 12 years with intermittent asthma were randomly assigned 1:1 to receive violet syrup or placebo along with the common standard treatments in both groups (short-acting β-agonist). Both groups were evaluated in terms of the duration until cough suppression was achieved. No significant difference was observed in basic characteristics. The duration lasting to yield more than 50% cough reduction and 100

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Dinesh, D. Thore Geeta N. Kaje Miss. Rupali B. Jadhav Pavanraj B. Lodwal Ingle Ram B. "Formulation And Evaluation Of Herbal Cough Syrup From Seeds Extract Of Hedge Mustard." International Journal of Pharmaceutical Sciences 2, no. 7 (2024): 1587–92. https://doi.org/10.5281/zenodo.12793003.

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The recent years there is a spurt in the interest regarding survival of Ayurvedic forms of medication. In the  global  perspective, there  is  a  shift towards the  use  of medicine  of herbal  origin,  as  the dangers and the shortcoming of modern medicine have started getting more apparent, majority of Ayurvedic formulation are prepared from herbs. Syrup is very popular dosage form of cough and cold medications, ease of patient compliance. The objective of this study is to   develop  a herbal cough syrup and

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Heidemann, Steven. "Microtubules, leukemia, and cough syrup." Blood 107, no. 6 (2006): 2216–17. http://dx.doi.org/10.1182/blood-2005-12-5142.

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&NA;. "Cough syrup may be lethal." Nursing 37, no. 3 (2007): 31–32. http://dx.doi.org/10.1097/01.nurse.0000261813.95521.6d.

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Shivraj, Sawant*1 Tushar Gaikwad2. "Formulation and Evaluation of Ginger Herbal Cough Syrup." International Journal of Scientific Research and Technology 2, no. 4 (2025): 256–68. https://doi.org/10.5281/zenodo.15199532.

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The formulation and evaluation of herbal ginger syrup aim to harness the medicinal properties of ginger (Zingiber officinale) in a convenient, consumable form for the management of various health issues. Ginger, known for its anti-inflammatory, anti-nausea, and digestive benefits, has been incorporated into a syrup with the addition of natural sweeteners like honey and flavor-enhancing ingredients such as lemon. The syrup is designed to alleviate conditions such as nausea, indigestion, and respiratory discomfort. The formulation process involves selecting optimal concentrations of ginger extra

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Mohtasham, Neda, Amanollah Zarei Ahmadi, Mohsen Alisamir, Nader Shakiba Maram, and Arash Larki. "Preparation of Sepestan Anti-cough Syrup and Comparison of its Effectiveness With Diphenhydramine Syrup in Treating Cough in Children With Upper Respiratory Tract Infection: A Double-blind Randomized Clinical Trial." Jundishapur Journal of Medical Sciences 21, no. 4 (2022): 574–85. http://dx.doi.org/10.32598/jsmj.21.4.2923.

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Background and Objectives Antihistamine drugs for acute upper respiratory tract infection treatment in children have many side effects. In this study, a anti-cough syrup was prepared from Cordia (Sepestan in Persian) extract and its effect was compared to that of diphenhydramine syrup on cough relief of children with upper respiratory tract infection. Subjects and Methods This double-blind randomized clinical trial was conducted on 124 children with upper respiratory tract infection aged 6-12 years referred to Abouzar Hospital in Ahvaz, Iran during 2019- 2021 in two treatment groups. The first

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Morozova, I. V., and M. O. Shalamay. "Acute viral respiratory infections are topical approaches to cough therapy in children." Reports of Vinnytsia National Medical University 23, no. 1 (2019): 125–28. http://dx.doi.org/10.31393/reports-vnmedical-2019-23(1)-21.

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Problem of cough treatment at the background of acute respiratory infections in children was discussed in an article. We presented possibility of plant origin drugs usage in case of acute cough symptom presence. We examined efficacy of syrup Ivy in case of acute respiratory diseases in 40 children from 3 up to 10 years of age that passed treatment in infection-diagnostic department of Vinnytsya regional children’s hospital. We analyzed results of the syrup Ivy usage in patients with acute cough in case of acute respiratory infections with evaluation of the clinical dynamic. Duration and qualit

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H. Dave, Pavithra, Deepa Gurunathan, and Madhu Sudhan Vasantharajan. "Comparison of pH Levels of the Saliva before and after the Consumption of Cough Syrups in Children." Biomedical and Pharmacology Journal 11, no. 3 (2018): 1443–48. http://dx.doi.org/10.13005/bpj/1509.

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Pediatric syrup formulations have been used for a long time in medicine. Cough syrups and other liquid medications are available easily and widely accepted by the children. The high intake of oral medications can be the causative factor for dental erosion and decay. Hence the aim of this study is to compare the efficacy in the pH levels of the saliva before and after the consumption of cough syrups. The study included 50 volunteer children. Children were recruited from the general medicine ward at Saveetha Medical College and Hospitals. Criteria for inclusion are candidates to be completely re

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Dang, Devra K. "Pediatric cough: Placebo cough syrup better than no treatment." Pharmacy Today 21, no. 1 (2015): 16. http://dx.doi.org/10.1016/s1042-0991(15)30528-4.

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Lavhale, Pallavi Manish, Arti Shakya, Payal Kesharwani, and Ankita Trivedi. "RECENT ADVANCEMENTS IN COUGH MANAGEMENT: EMERGING STRATEGIES AND THERAPIES." Journal of Applied Pharmaceutical Sciences and Research 6, no. 3 (2023): 1–7. http://dx.doi.org/10.31069/japsr.v6i3.01.

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The management of cough, a prevalent symptom impacting the quality of life, has undergone transformative developments propelled by recent research. Cough syrups, longstanding components in cough management, have witnessed substantial progress aimed at refining efficacy, safety, and targeted delivery. Modern formulations exhibit innovations in drug delivery systems, heightening bioavailability and allowing targeted drug release. Extended-release preparations and mucoadhesive syrups offer prolonged cough suppression or augmented expectorant effects. The incorporation of innovative compounds intr

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Dudnyk, V. M., I. V. Моrozova, M. O. Shalamai, and Y. V. Vyzhga. "Experience of the use of combined phytopreparations in the treatment of respiratory tract diseases." Reports of Vinnytsia National Medical University 22, no. 1 (2018): 46–50. http://dx.doi.org/10.31393/reports-vnmedical-2018-22(1)-09.

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The article showed the problem of integrated management of children different age groups with upper respiratory tract viral infection. It reflected modern approach of using multicomponent herbal medicine for cough therapy in children in the practice of pediatrician. We evaluated necessity of the prescription and effect of the herbal drug in syrup type Gamma in case of acute respiratory diseases in 50 children, from the age of 2 up to 15 years of life, that were treated at infectious-diagnostic department of Vinnytsya regional children’s hospital and had cough symptom. Analysis of the results o

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Lokhande, Prerana M.1 Dahale Ankita A.2 Damkondwar santosh T*.3. "Herbal Cough Syrup From Ficus Religiosa Leaves." International Journal in Pharmaceutical Sciences 2, no. 4 (2024): 212–18. https://doi.org/10.5281/zenodo.10913689.

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The cough is most common problem are faced by all people. There are two types of cough  dry cough and wet cough. The aim of this study to develop and optimize herbal cough syrup utilizing Ficus Religious commonly known as peepal tree, through decoction method . Ficus Religious has been traditionally recognized for its medicinal properties, particularly in managing cough symptoms.  Among respiratory complications, cough is an important defensive pulmonary relflex  that removes fluids, irritants or foreign substances from the respiratory tract. The chemical analysis showed that Fi

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Badhe Payal and Gugale Vaishnavi. "Formulation and evaluation of herbal syrup using kiwi basil orange peel." World Journal of Biology Pharmacy and Health Sciences 22, no. 3 (2025): 512–18. https://doi.org/10.30574/wjbphs.2025.22.3.0569.

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The natural herbal syrup was formulated by adding the extracts of Basil leaves, Kiwi, Orange peel Constituents. It may also act as a bronchodilator as an expectorant. Leaves extract is a traditional medicine and reported to use in the management of cough. An herbal syrup is prepared by combining a concentrated decoction with either honey or sugar, and sometimes alcohol. Herbal plants and formulations are used for the many types of diseases like cough syrup and many more other diseases.

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Evstifeeva, G. Yu, O. Yu Trusova, E. I. Danilova, and V. V. Sumenko. "Clinical efficiency of treatment of cough in pediatric practice." Medical Council, no. 2 (February 16, 2019): 194–98. http://dx.doi.org/10.21518/2079-701x-2019-2-194-198.

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Cough is one of the most common reasons why parents bring their children to the pediatrician. The article presents the results of a study of the clinical efficacy of treatment of dry cough using Sinecod syrup. A total of 60 children aged 3–15 years with the upper respiratory tract infections and complaints of dry (non-productive) cough were enrolled in the study. In Group 1 (the main group), the children received Sinecod syrup in addition to the standard therapy, in Group 2 (the comparison group) children received Stoptussin-Phyto syrup. The effectiveness of treatment was evaluated based on th

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Sagitova, Gulnara R., Vladimir A. Shuldais, Nonna V. Klyueva, Elena M. Shaforostova, Vasiliy M. Sereda, and Diana M. Faradzhova. "Effectiveness of combined herbal products for cough during acute respiratory diseases in children in outpatient settings." Pediatrics. Consilium Medicum, no. 4 (December 15, 2024): 358–65. https://doi.org/10.26442/26586630.2024.4.203046.

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Background. Coughing is an important defense mechanism of the respiratory system to remove mucus, harmful substances and infectious agents from the respiratory tract. There are pharmacological ways to influence different loci of the cough reflex arc. The most physiologic approach is to act at the level of cough receptors in order to preserve clearance function while maintaining a high quality of life for patients. This goal can be achieved by using combinations of substances of plant origin, in particular cumin fruit, ginger rhizome extract, althea root extract and ivy leaf extract, carob syru

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Yadav, Dinkar, Hunny Verma, Neha Yadav, and Kapil Bhalla. "Overzealous over-the-counter cough syrup ingestion leading to serious manifestation in a child – A case report." Journal of Family Medicine and Primary Care 13, no. 11 (2024): 5367–69. http://dx.doi.org/10.4103/jfmpc.jfmpc_130_24.

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ABSTRACT Cough is a protective reflex that allows clearance of secretions from upper respiratory tract. It is not a disease by itself but a symptom of underlying disease. In a majority of cases, it is self-limiting and requires only supportive care. But over-the-counter cough syrups are inadvertently used to relieve cough in Indian settings. We hereby report a case of a 6-year-old girl child who presented to pediatrics emergency services with complaints of loss of consciousness and abnormal body movement after ingestion of dextromethorphan and chlorpheniramine containing cough syrup. All inves

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Adam, Ramlatu Musa, Aishatu Muhammad Bello, Jalil Idi James, Alhassan Ahmad Siddan, and Aisami Abubakar. "The Effect of High Dosage of Codeine-Containing Cough Syrup on Renal Function on Albino Rats." Journal of Environmental Microbiology and Toxicology 9, no. 2 (2021): 38–40. http://dx.doi.org/10.54987/jemat.v9i2.646.

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Codeine-containing cough syrup (CCS) is one of the most abused drugs in the world especially among the youths. However, there is need to study the nephrotoxic effect associated with oral administration of the drug and to ascertain its effect on the kidney. Consequently, understanding the renal abnormalities in chronic use of CCS will be crucial for effective development of interventions. This study assessed the nephrotoxic effect associated with oral administration of codeine-containing cough syrup (Tutolin with Codeine) in albino rats, using the level of creatinine, urea, sodium, potassium an

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Chu, Kai-On, and Kam-Chung Tin. "Analysis of Antihistamines in Cough Syrup." Analytical Letters 31, no. 11 (1998): 1879–90. http://dx.doi.org/10.1080/00032719808005268.

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SPLETE, HEIDI. "Cough Syrup Can Promote Dental Caries." Pediatric News 40, no. 5 (2006): 39. http://dx.doi.org/10.1016/s0031-398x(06)71061-x.

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Borde, Milind, and S. Haque Nizamie. "DEPENDENCE ON A COMMON COUGH SYRUP." Lancet 331, no. 8588 (1988): 760–61. http://dx.doi.org/10.1016/s0140-6736(88)91557-7.

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Pacheco, Eva, Cynthia Crespo, Alexandra Mascret, et al. "Effectiveness and safety of AROMAFORCE® junior cough syrup in pediatric patients with acute upper respiratory conditions." Journal of Pediatrics & Neonatal Care 14, no. 1 (2024): 14–20. http://dx.doi.org/10.15406/jpnc.2024.14.00535.

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Aim: The purpose of this study was to evaluate the effectiveness and safety of Aromaforce® Junior Cough Syrup (AJCS) in treating acute upper respiratory tract infection-related coughs in children, and it served as a post-marketing clinical follow-up. Methods: Prospective, multicenter, open-label, controlled clinical investigation conducted under normal conditions of use to evaluate the antitussive effectiveness of a mucilage-based syrup in pediatric patients (aged 2 to 12 years) as compared to increased hydration measures (control group), with a 1-week follow-up. Likert severity scores were us

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Al−Kaf, Ali G., Saeed M. Alghalibi, and Wadhah H. Edrees. "Evaluation of microbial and physico-chemical qualities of some cough syrups marketed in Sana’a city, Yemen." Journal of Pharmacy & Pharmacognosy Research 3, no. 1 (2015): 92–99. http://dx.doi.org/10.56499/jppres14.027_3.4.92.

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Context: Microbial contamination of cough syrups can bring clinical hazards to the users or patients as well as physical and chemical changes in the product. Aims: To evaluate the microbial and physicochemical characteristics of two hundred samples of four different types of cough syrups marketed in Sana’a city, Yemen. Methods: All collected samples were subjected to the following examinations: the total microbial count, type of isolated microorganisms, physical parameters, and concentration of active ingredients were identified and assessed by standard techniques described in US Pharmacopeia.

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Ambikar, Digambar B., and Vishesh S. Mittal. "Knowledge, attitude, and behaviour of patients towards use of cough and cold preparations: a comprehensive surveyKnowledge, attitude, and behaviour of patients towards use of cough and cold preparations: a comprehensive survey." International Journal Of Community Medicine And Public Health 9, no. 10 (2022): 3679. http://dx.doi.org/10.18203/2394-6040.ijcmph20222555.

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Background: Cough, cold and related discomforts are the most common discomforts affecting general population, which can adversely affects subjects’ quality of life due to its physical, social, and psychological effects. To know the patients perception towards cough and cold preparation is need of hour for health care industry.Methods: This study investigated the knowledge, attitude and behaviour of patients toward use of cough and cold preparations. Questionnaires were distributed to patients approaching to pharmacy for purchasing these drugs.Results: The age group was from 17 to 55. In our st

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Fred, Ssembatia. "Evaluation of Hematological and Biochemical Effects of Kabuuti Herbal Cough Syrup: A Sub-acute Study in Wistar Rats." IDOSR JOURNAL OF BIOCHEMISTRY, BIOTECHNOLOGY AND ALLIED FIELDS 9, no. 2 (2024): 15–21. http://dx.doi.org/10.59298/idosr/jbbaf/24/92.15210000.

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Herbal medicines, including Kabuuti cough syrup, have gained popularity in treating various ailments, yet their safety and efficacy require scientific scrutiny. This study aimed to evaluate the hematological and biochemical effects of Kabuuti herbal cough syrup after 28 days of oral administration in Wistar rats. The herbal extracts, containing secondary metabolites like terpenes, alkaloids, steroids, and phenols, were administered at different doses to rats, with distilled water as a control. Hematological and biochemical parameters were assessed, showing no statistically significant changes

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Zakharova, I. N., and N. G. Sugyan. "Therapeutic efficacy and tolerability of syrup based on natural active ingredients in the treatment of cough in children with an acute respiratory infection." Meditsinskiy sovet = Medical Council, no. 1 (March 2, 2022): 190–95. http://dx.doi.org/10.21518/2079-701x-2022-16-1-190-195.

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Introduction. Acute respiratory infections occupy the leading place in the structure of total infectious morbidity and account for more than 90% of all cases of infection. One of the most frequent clinical symptoms of acute respiratory infections is cough.Aim. To evaluate the therapeutic efficacy and tolerability of syrup based on active natural components in the treatment of cough in 2 to 7 years old children.Materials and methods. Patients 2 to 7 years old diagnosed with mild to moderate acute respiratory infections who had been coughing for no more than 3 days were included in the study.Res

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Andi Ardiansyah Arifin, Megawati, Nurjannah, and Syamsu Nur. "Evaluasi Keamanan Sirup Batuk Anak Melalui Deteksi Dietilen Glikol." Media Farmasi 21, no. 1 (2025): 32–39. https://doi.org/10.32382/mf.v21i1.1255.

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A recent report highlighted cases of contamination in children's cough syrup containing diethylene glycol, which poses potential health risks for children. This study aims to identify the presence of diethylene glycol in various children's cough syrups sold in Makassar City using Thin Layer Chromatography (TLC) and FT-IR Spectroscopy methods. A total of 9 samples of children's cough syrup from three different brands, each originating from three batches, were analyzed in this study. The TLC analysis results showed significant differences between the samples and the standard. The Rf values of th

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Suzuki, Moeko, Haruhiko Higashi, Shuntaro Ikeda, and Osamu Yamaguchi. "Methylephedrine-induced heart failure in a habitual user of paediatric cough syrup: a case report." European Heart Journal - Case Reports 4, no. 3 (2020): 1–4. http://dx.doi.org/10.1093/ehjcr/ytaa095.

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Abstract Background For relief of cold symptoms, methylephedrine is considered to be safer than ephedrine, particularly when used at the predetermined dose. It is often present in various over-the-counter (OTC) drugs for cold, including paediatric cough syrups. Case summary A 52-year-old man presented with worsening dyspnoea and anorexia for 2 weeks. He was a night shift worker and had been habitually taking large doses of methylephedrine-containing paediatric cough syrup for 20 years for sleep averting. On admission, his chest X-ray revealed pulmonary congestion and electrocardiogram showed s

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Kiran, Kumari* Akhil Thakur Ajeet Kumar Nikhil Kumar. "Formulation and evaluation of polyherbal antitussive." International Journal in Pharmaceutical Sciences 2, no. 5 (2024): 992–97. https://doi.org/10.5281/zenodo.11221410.

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Cough remain as untreated and symptoms of multiple disease. Cough remains a serious unmet clinical problem, both as a symptom of a range of other conditions such as asthma, chronic obstructive pulmonary disease, gastro oesophageal reflux, and as a problem in its own right in patients with chronic cough of unknown origin. Cough remains a major unmet medical need and, although the centrally acting opioids have remained the antitussive drug of choice for decades, such opioids possess many unwanted side-effects. Now a days the synthetic and novel drugs are the major source of curing any type of di

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