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Journal articles on the topic 'Cough'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Barata, Filipe, Peter Tinschert, Frank Rassouli, et al. "Automatic Recognition, Segmentation, and Sex Assignment of Nocturnal Asthmatic Coughs and Cough Epochs in Smartphone Audio Recordings: Observational Field Study." Journal of Medical Internet Research 22, no. 7 (2020): e18082. http://dx.doi.org/10.2196/18082.

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Background Asthma is one of the most prevalent chronic respiratory diseases. Despite increased investment in treatment, little progress has been made in the early recognition and treatment of asthma exacerbations over the last decade. Nocturnal cough monitoring may provide an opportunity to identify patients at risk for imminent exacerbations. Recently developed approaches enable smartphone-based cough monitoring. These approaches, however, have not undergone longitudinal overnight testing nor have they been specifically evaluated in the context of asthma. Also, the problem of distinguishing p

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2

Vally, M., and M. O. E. Irhuma. "Management of Cough: a practical approach." South African Family Practice 58, no. 4 (2016): 35–39. http://dx.doi.org/10.4102/safp.v58i4.4486.

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On a regular day, healthcare providers will be contacted by one or more health seekers presenting with cough as a symptom. Cough has been considered an important physiological reflex that protects the airways from aspiration of foreign materials. Cough is one of the most common symptoms for which people seek medical attention from their healthcare practitioners. The common classifications for cough include acute, subacute and chronic cough. Such classification is time dependant. Acute cough is generally self-limiting, while subacute and chronic coughs have various different causes. There are m

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3

Cho, Peter S. P., Hannah V. Fletcher, Richard D. Turner, Caroline J. Jolley, and Surinder S. Birring. "Impaired cough suppression in chronic refractory cough." European Respiratory Journal 53, no. 5 (2019): 1802203. http://dx.doi.org/10.1183/13993003.02203-2018.

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Functional brain imaging in individuals with chronic cough demonstrates reduced activation in cortical regions associated with voluntary cough suppression. Little is known about the ability of patients with chronic cough to suppress cough. This study aimed to compare the ability to voluntarily suppress cough during inhaled capsaicin challenge in participants with chronic refractory cough with that in healthy controls. In addition, this study aimed to assess the repeatability of capsaicin challenge test with voluntary cough suppression.Participants with chronic refractory cough and healthy cont

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4

SHAIKH, AYESHA NAYYER KAMAL, Mahdi Ali S. V. Mir, Towfeeq Hussain M Syed, and Naushaba Ansari. "The Respiratory Reflex of Cough: A Comparative Study of Contemporary Medicine and Unani Concepts." Journal of Drug Delivery and Therapeutics 14, no. 10 (2024): 111–15. http://dx.doi.org/10.22270/jddt.v14i10.6820.

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Cough suddenly and frequently helps to remove mucus, irritants, foreign substances, and bacteria from the airways. It can be a symptom of a respiratory infection like the common cold, bronchitis, tuberculosis, influenza, smoking, or other health issues. Contemporary texts describe several kinds of coughs, including acute, chronic, and subacute coughs, coughs that produce or do not produce mucus, and specific types like Reflex cough, voluntary cough, and evoked cough. In Unani texts, cough is referred to as diseases rather than symptoms. it is also called as “Sual” in Arabic, “Surfa” in Persian

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5

Xiang, Anbo, Yoshiyuki Uchida, Akihiro Nomura, et al. "Effects of airway inflammation on cough response in the guinea pig." Journal of Applied Physiology 85, no. 5 (1998): 1847–54. http://dx.doi.org/10.1152/jappl.1998.85.5.1847.

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We have developed a guinea pig model for cough related to allergic airway inflammation. Unanesthetized animals were exposed to capsaicin aerosols for 10 min, and cough frequency was counted during this period. The cough evaluation was performed by the following three methods: visual observation, acoustic analysis, and monitoring of pressure changes in the body chamber. These analyses clearly differentiated a cough from a sneeze. To elucidate the relationship between cough response and airway inflammation, animals were immunosensitized and multiple challenged. Sensitized guinea pigs presented n

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6

Yang, Bennett E., and Joel Moss. "Cough, Cough." Chest 163, no. 4 (2023): 746–48. http://dx.doi.org/10.1016/j.chest.2022.12.009.

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7

Barry, P. W., N. P. Mason, M. Riordan, and C. O'Callaghan. "Cough Frequency and Cough-Receptor Sensitivity are Increased in Man at Altitude." Clinical Science 93, no. 2 (1997): 181–86. http://dx.doi.org/10.1042/cs0930181.

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1. Travellers to high altitude often complain of paroxysmal cough, which has not been previously investigated. We recorded overnight cough frequency and cough-receptor sensitivity to inhaled citric acid in a group of climbers travelling to 5300 m or higher. 2. Cough frequency, monitored in ten subjects, increased from a median of 0 coughs at sea level (range 0–1) to 5 coughs at 5000 m (range 0–13) and to over 60 coughs in subjects ascending to 7000 m. Citric acid cough threshold, measured in 42 subjects, was unchanged on arrival at 5300 m compared with sea level (geometric mean difference 1.26

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8

Hee, Hwan Ing, BT Balamurali, Arivazhagan Karunakaran, et al. "Development of Machine Learning for Asthmatic and Healthy Voluntary Cough Sounds: A Proof of Concept Study." Applied Sciences 9, no. 14 (2019): 2833. http://dx.doi.org/10.3390/app9142833.

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(1) Background: Cough is a major presentation in childhood asthma. Here, we aim to develop a machine-learning based cough sound classifier for asthmatic and healthy children. (2) Methods: Children less than 16 years old were randomly recruited in a Children’s Hospital, from February 2017 to April 2018, and were divided into 2 cohorts—healthy children and children with acute asthma presenting with cough. Children with other concurrent respiratory conditions were excluded in the asthmatic cohort. Demographic data, duration of cough, and history of respiratory status were obtained. Children were

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9

den Brinker, Albertus C., Okke Ouweltjes, Ronald Rietman, Susannah Thackray-Nocera, Michael G. Crooks, and Alyn H. Morice. "Nighttime Cough Characteristics in Chronic Obstructive Pulmonary Disease Patients." Sensors 25, no. 2 (2025): 404. https://doi.org/10.3390/s25020404.

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Coughing is a symptom of many respiratory diseases. An increased amount of coughs may signal an (upcoming) health issue, while a decreasing amount of coughs may indicate an improved health status. The presence of a cough can be identified by a cough classifier. The cough density fluctuates considerably over the course of a day with a pattern that is highly subject-dependent. This paper provides a case study of cough patterns from Chronic Obstructive Pulmonary Disease (COPD) patients as determined by a stationary semi-automated cough monitor. It clearly demonstrates the variability of cough den

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10

Poliacek, Ivan, Kendall F. Morris, Bruce G. Lindsey, et al. "Blood pressure changes alter tracheobronchial cough: computational model of the respiratory-cough network and in vivo experiments in anesthetized cats." Journal of Applied Physiology 111, no. 3 (2011): 861–73. http://dx.doi.org/10.1152/japplphysiol.00458.2011.

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We tested the hypothesis, motivated in part by a coordinated computational cough network model, that alterations of mean systemic arterial blood pressure (BP) influence the excitability and motor pattern of cough. Model simulations predicted suppression of coughing by stimulation of arterial baroreceptors. In vivo experiments were conducted on anesthetized spontaneously breathing cats. Cough was elicited by mechanical stimulation of the intrathoracic airways. Electromyograms (EMG) of inspiratory parasternal, expiratory abdominal, laryngeal posterior cricoarytenoid (PCA), and thyroarytenoid mus

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11

Sanchez-Olivieri, Isabel, Matthew Rudd, Juan Carlos Gabaldon-Figueira, et al. "Performance evaluation of human cough annotators: optimal metrics and sex differences." BMJ Open Respiratory Research 10, no. 1 (2023): e001942. http://dx.doi.org/10.1136/bmjresp-2023-001942.

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IntroductionDespite its high prevalence and significance, there is still no widely available method to quantify cough. In order to demonstrate agreement with the current gold standard of human annotation, emerging automated techniques require a robust, reproducible approach to annotation. We describe the extent to which a human annotator of cough sounds (a) agrees with herself (intralabeller or intrarater agreement) and (b) agrees with other independent labellers (interlabeller or inter-rater agreement); we go on to describe significant sex differences in cough sound length and epochs size.Mat

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12

Wang, Yiping, Mustafaa Wahab, Tianqi Hong, et al. "Automated Cough Analysis with Convolutional Recurrent Neural Network." Bioengineering 11, no. 11 (2024): 1105. http://dx.doi.org/10.3390/bioengineering11111105.

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Chronic cough is associated with several respiratory diseases and is a significant burden on physical, social, and psychological health. Non-invasive, real-time, continuous, and quantitative monitoring tools are highly desired to assess cough severity, the effectiveness of treatment, and monitor disease progression in clinical practice and research. There are currently limited tools to quantitatively measure spontaneous coughs in daily living settings in clinical trials and in clinical practice. In this study, we developed a machine learning model for the detection and classification of cough

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13

Gavliakova, S., T. Dolak, H. Licha, S. Krizova, and J. Plevkova. "Cineole, Thymol and Camphor Nasal Challenges and their Effect on Nasal Symptoms and Cough in an Animal Model." Acta Medica Martiniana 13, no. 2 (2013): 5–13. http://dx.doi.org/10.2478/acm-2013-0012.

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Abstract Inhalation of aromatic vapours suppressed coughing induced by citric acid (CA) in naive animals. No data are available about their effects in an animal model with primarily up-regulated cough reflex. New data indicate that aromatic vapours suppress cough via effect on nasal sensory nerves. The aim of our study was to ascertain the efficacy of nasal application of 1,8-cineole, thymol and camphor on nasal symptoms and CA induced cough in validated model of up-regulated cough reflex. Guinea pigs (n=13) were sensitized by intraperitoneal administration of ovalbumin (OVA) and sensitization

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14

Stafford, Ryan E., Stuart Mazzone, James A. Ashton-Miller, Christos Constantinou, and Paul W. Hodges. "Dynamics of male pelvic floor muscle contraction observed with transperineal ultrasound imaging differ between voluntary and evoked coughs." Journal of Applied Physiology 116, no. 8 (2014): 953–60. http://dx.doi.org/10.1152/japplphysiol.01225.2013.

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Coughing provokes stress urinary incontinence, and voluntary coughs are employed clinically to assess pelvic floor dysfunction. Understanding urethral dynamics during coughing in men is limited, and it is unclear whether voluntary coughs are an appropriate surrogate for spontaneous coughs. We aimed to investigate the dynamics of urethral motion in continent men during voluntary and evoked coughs. Thirteen men (28–42 years) with no history of urological disorders volunteered to participate. Transperineal ultrasound (US) images were recorded and synchronized with measures of intraabdominal press

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15

Thorpe, CW, LJ Toop, and KP Dawson. "Towards a quantitative description of asthmatic cough sounds." European Respiratory Journal 5, no. 6 (1992): 685–92. http://dx.doi.org/10.1183/09031936.93.05060685.

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This study describes a method of quantitatively characterizing cough sounds using digital signal processing techniques. Differences between asthmatic and non-asthmatic cough sounds are presented. Coughs from 12 asthmatic and 5 non-asthmatic subjects were analysed. Cough sounds and flows were digitized, at a sampling rate of 5 kHz, before and after a free-running exercise test. Individual coughs were divided into two or three phases, corresponding to the initial glottal opening burst, the quieter middle phase, and (sometimes) the final closing burst. Standard signal processing techniques were t

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16

Romaniuk, Jarosław, Krzysztof Kowalski, and Thomas Dick. "The role of pulmonary stretch receptor activation during cough in dogs." Acta Neurobiologiae Experimentalis 57, no. 1 (1997): 21–29. http://dx.doi.org/10.55782/ane-1997-1207.

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The role of pulmonary stretch receptors in the modulation of expiratory muscle activity during cough is controversial. To evaluate their potential influence on expiratory effort during cough, we compared expiratory muscle activity during unobstructed cough to that during obstructed cough in which the trachea was occluded at the end-inspiration and maintained throughout the subsequent expiration. Cough was evoked by mechanical stimulation of the intrathoracic trachea in 9 anesthetized, tracheotomized dogs. Peak triangularis sterni (TS), internal intercostal (IIC) and transversus abdominis (TA)

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17

Hilton, Emma, Imran Satia, Kimberley Holt, Ashley A. Woodcock, John Belcher, and Jaclyn A. Smith. "The effect of pain conditioning on experimentally evoked cough: evidence of impaired endogenous inhibitory control mechanisms in refractory chronic cough." European Respiratory Journal 56, no. 6 (2020): 2001387. http://dx.doi.org/10.1183/13993003.01387-2020.

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The pathophysiology of refractory chronic cough (RCC) is unclear. We hypothesised that endogenous inhibitory control mechanisms, such as those activated by noxious stimuli inducing pain (conditioned pain modulation) may be capable of inhibiting coughing and urge to cough evoked by inhaled capsaicin. Furthermore, these mechanisms may be impaired in patients with RCC.The objective was to investigate the effects of pain on cough and urge to cough in healthy volunteers and RCC patients. Healthy volunteers and RCC patients underwent a randomised, controlled, four-way crossover study comparing the e

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18

Lalloo, UG, S. Lim, R. DuBois, PJ Barnes, and KF Chung. "Increased sensitivity of the cough reflex in progressive systemic sclerosis patients with interstitial lung disease." European Respiratory Journal 11, no. 3 (1998): 702–5. http://dx.doi.org/10.1183/09031936.98.11030702.

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Cough is a common presenting symptom of interstitial lung disease (ILD). The aim of this study was to examine the cough reflex in patients with progressive systemic sclerosis (PSS), with and without associated ILD. The cough reflex to inhalation of chloride deficient solutions and capsaicin was determined in patients with PSS with associated ILD (n=12), compared to patients with PSS without ILD (n=12). In addition, patients with a chronic dry cough (n=12) and healthy subjects (n=10) without cough were studied. Cough responses to inhalation of isotonic solutions containing 150, 75, 37.5 and 0 m

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19

Ewig, Jeffrey M. "Chronic Cough." Pediatrics In Review 16, no. 2 (1995): 72–73. http://dx.doi.org/10.1542/pir.16.2.72.

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Cough is a reflex that protects the lungs from aspirating food or inhaling irritants. It is a key component of the nonimmune pulmonary defense system. The cough that accompanies most common respiratory infections usually resolves in 7 to 10 days and rarely is a cause of concern. The patient who has frequent viral infections may complain of a "chronic" cough, but a careful history will reveal a shorter duration of repetitive episodes with coughs resolving completely in between infections. Chronic cough usually is defined as lasting for more than 3 to 4 weeks. Chronic cough is a symptom, not a d

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20

Lalloo, U. G., A. J. Fox, M. G. Belvisi, K. F. Chung, and P. J. Barnes. "Capsazepine inhibits cough induced by capsaicin and citric acid but not by hypertonic saline in guinea pigs." Journal of Applied Physiology 79, no. 4 (1995): 1082–87. http://dx.doi.org/10.1152/jappl.1995.79.4.1082.

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Acidic solutions mimick many of the effects of capsaicin (Cap), including pain, bronchoconstriction, cough, and sensory neuropeptide release. Evidence from the use of the Cap antagonist capsazepine suggests that in some cases protons act at the Cap receptor. In the present study, we have investigated whether cough evoked by Cap and citric acid (CA) is mediated specifically via the Cap receptor on airway sensory nerves. We have examined the effects of capsazepine on Cap-, CA-, and hypertonic saline-induced cough and also on CA-induced nasal irritation in awake guinea pigs. Capsazepine was nebul

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21

Balamurali, B. T., Hwan Ing Hee, Saumitra Kapoor, et al. "Deep Neural Network-Based Respiratory Pathology Classification Using Cough Sounds." Sensors 21, no. 16 (2021): 5555. http://dx.doi.org/10.3390/s21165555.

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Intelligent systems are transforming the world, as well as our healthcare system. We propose a deep learning-based cough sound classification model that can distinguish between children with healthy versus pathological coughs such as asthma, upper respiratory tract infection (URTI), and lower respiratory tract infection (LRTI). To train a deep neural network model, we collected a new dataset of cough sounds, labelled with a clinician’s diagnosis. The chosen model is a bidirectional long–short-term memory network (BiLSTM) based on Mel-Frequency Cepstral Coefficients (MFCCs) features. The result

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22

Choudry, NB, and RW Fuller. "Sensitivity of the cough reflex in patients with chronic cough." European Respiratory Journal 5, no. 3 (1992): 296–300. http://dx.doi.org/10.1183/09031936.93.05030296.

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Cough may occur in association with excess bronchial secretions and may, therefore, be productive. However, in a proportion of patients the cough is non-productive and a possible association with an enhanced response of the cough reflex has been postulated. Using the irritant capsaicin, the sensitivity of the cough reflex was measured in 363 individuals. A questionnaire was used to divide subjects into three groups: Group A) non-coughing controls; Group B) subjects with non-productive cough; and Group C) subjects with productive cough. The group means (+/- 99% confidence interval (CI)) of the

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23

Cho, Peter S. P., Hannah V. Fletcher, Irem S. Patel, Richard D. Turner, Caroline J. Jolley, and Surinder S. Birring. "Cough hypersensitivity and suppression in COPD." European Respiratory Journal 57, no. 5 (2020): 2003569. http://dx.doi.org/10.1183/13993003.03569-2020.

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Cough reflex hypersensitivity and impaired cough suppression are features of chronic refractory cough (CRC). Little is known about cough suppression and cough reflex hypersensitivity in cough associated with chronic obstructive pulmonary disease (COPD). This study investigated the ability of patients with COPD to suppress cough during a cough challenge test in comparison to patients with CRC and healthy subjects. This study also investigated whether cough reflex hypersensitivity is associated with chronic cough in COPD.Participants with COPD (n=27) and CRC (n=11) and healthy subjects (n=13) un

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24

Rissardo, JamirPitton, and AnaLeticia Fornari Caprara. "Cough, cough-induced, and primary cough headache." Matrix Science Medica 6, no. 4 (2022): 117. http://dx.doi.org/10.4103/mtsm.mtsm_6_22.

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25

Bennett, W. D., and K. L. Zeman. "Effect of enhanced supramaximal flows on cough clearance." Journal of Applied Physiology 77, no. 4 (1994): 1577–83. http://dx.doi.org/10.1152/jappl.1994.77.4.1577.

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Efficiency of cough for clearing mucus from the lungs is believed to be a function of peak airflow velocities in the airways. Initial transient supramaximal flows are characteristic of cough, and these peak flow rates can be enhanced by placing a triggered shutter at the mouth, serving the role of the epiglottis. Using radiolabeled monodispersed aerosols (99mTc-iron oxide) and gamma camera analysis, we measured over a 2-h period the efficacy of 60 voluntary vs. shutter coughs for clearing mucus from the airways of patients (n = 15) with chronic airway obstruction (mean ratio of forced expired

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26

Neuschlová, Martina, and R. Pecova. "Cough Reflex Sensitivity Testing in Asthmatic Patients and Healthy Volunteers." Acta Medica Martiniana 13, Supplement-1 (2013): 21–27. http://dx.doi.org/10.2478/acm-2013-0003.

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Abstract Asthma and allergic diseases are complex conditions caused by a combination of genetic and environmental factors. Cough is a major symptom in some people with asthma. Cough reflex sensitivity (CRS) test with capsaicin is one of the most important method for cough studying. Cough reflex sensitivity was defined as the lowest concentration of capsaicin that elicited 2 or more (C2) and 5 or more coughs (C5). The aim of this study was to find out a cough reflex sensitivity in patients with asthma bronchiale and in healthy volunteers. In the present study we conclude that cough reflex sensi

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27

Stone, R., P. J. Barnes, and R. W. Fuller. "Contrasting effects of prostaglandins E2 and F2 alpha on sensitivity of the human cough reflex." Journal of Applied Physiology 73, no. 2 (1992): 649–53. http://dx.doi.org/10.1152/jappl.1992.73.2.649.

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Prostaglandins have been shown to influence the sensitivity of the cough reflex. To investigate putative mechanisms of this, we examined the effects of inhaled prostaglandins E2 (PGE2) and F2 alpha (PGF2 alpha) on human cough responses elicited by two challenges, low chloride solution and capsaicin, which may activate different neural pathways. Baseline cough challenges were followed after 2 h by five breaths of PGE2, PGF2 alpha, or citric acid as a control. Cough challenges were repeated after 1 min. Potentiation of capsaicin responses occurred after PGE2 (median increase 2 coughs/min, range

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28

Li, Wanzhen, Shengyuan Wang, Tongyangzi Zhang, Yiqing Zhu, Li Yu, and Xianghuai Xu. "Activation of Adenosine Triphosphate-Gated Purinergic 2 Receptor Channels by Transient Receptor Potential Vanilloid Subtype 4 in Cough Hypersensitivity." Biomolecules 15, no. 2 (2025): 285. https://doi.org/10.3390/biom15020285.

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Background: Transient receptor potential vanilloid subtype 4 (TRPV4) is a Ca2+-permeable non-selective cation channel that is involved in the development of cough hypersensitivity. Purinergic 2 receptors (P2X) belong to a class of adenosine triphosphate (ATP)-gated non-selective cation channels that also play an important role in cough hypersensitivity. Nevertheless, little is known about the interaction between them for cough hypersensitivity. The present study was designed to clarify the roles of TRPV4 and ATP-P2X receptors in cough hypersensitivity, and to explore the possible involvement o

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Satia, I., L. Mcgarvey, A. H. Morice, et al. "Characterization of Cough Phenotypes and Mannitol Evoked Coughs in Refractory and Unexplained Chronic Cough." American Journal of Respiratory and Critical Care Medicine 211, Abstracts (2025): A1963. https://doi.org/10.1164/ajrccm.2025.211.abstracts.a1963.

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30

AD, Shah, Apoorva BVS, Jain A, and Shah KV. "Cough without a cause: Habit cough / Tic cough." International Journal of Research in Medicine 9, no. 4 (2020): 5–8. http://dx.doi.org/10.38174/ijorim/9.4.2020.5-8.

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WALKER, LEWIS H. "Tic Cough μ Habit Cough μ Psychogenic Cough". Pediatric Asthma, Allergy & Immunology 1, № 2 (1987): 123–26. http://dx.doi.org/10.1089/pai.1987.1.123.

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Hara, Akinori, Hiroshi Odajima, Hiroshi Matsuzaki, et al. "Association between Cough and Ambient Polycyclic Aromatic Hydrocarbons in Patients with Chronic Cough: An Observational Study in Two Regions of Japan." Applied Sciences 12, no. 24 (2022): 12505. http://dx.doi.org/10.3390/app122412505.

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Ambient polycyclic aromatic hydrocarbons’ (PAHs) specific components are likely involved in respiratory disease development and exacerbation in children and adults. Airborne PAH exposure’s effects on cough symptoms in children and adults with chronic coughs in Kanazawa and Fukuoka, Japan, were investigated in this longitudinal study. A total of 98 patients with chronic coughs were enrolled and followed up between 1 April and 31 May 2020. The enrolled patients were non-smoking adults and children aged 3–83 years. Cough diaries were used to record and collect daily cough symptoms. High-performan

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Bolser, Donald C., John A. Hey, and Richard W. Chapman. "Influence of central antitussive drugs on the cough motor pattern." Journal of Applied Physiology 86, no. 3 (1999): 1017–24. http://dx.doi.org/10.1152/jappl.1999.86.3.1017.

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The present study was conducted to determine the effects of administration of centrally active antitussive drugs on the cough motor pattern. Electromyograms of diaphragm and rectus abdominis muscles were recorded in anesthetized, spontaneously breathing cats. Cough was produced by mechanical stimulation of the intrathoracic trachea. Centrally acting drugs administered included codeine, morphine, dextromethorphan, baclofen, CP-99,994, and SR-48,968. Intravertebral artery administration of all drugs reduced cough number (number of coughs per stimulus trial) and rectus abdominis burst amplitude i

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Kishanrao, Suresh. "Epidemiology & Management of Cough in Smaller Settings-An Indian Case Study." Journal of Quality in Health Care & Economics 6, no. 3 (2023): 1–13. http://dx.doi.org/10.23880/jqhe-16000331.

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Nearly every person experiences at least one episode of cough every year in their lifetime. Most, people seek care outside home only after trying known home remedies, especially when cough disturbs their sleep due to postnasal drip. Available data suggest that an average Indian adult has 3 episodes of cough per year, while an average child has 7-10 such episodes every year. The COVID-19 pandemic has increased the magnitude of cough across the world since early 2020. The most annoying part about a cough is “phlegm or mucus.” Mucus forms a protective lining in certain parts of our body, protects

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Morice, Alyn H., Michael M. Kitt, Anthony P. Ford, et al. "The effect of gefapixant, a P2X3 antagonist, on cough reflex sensitivity: a randomised placebo-controlled study." European Respiratory Journal 54, no. 1 (2019): 1900439. http://dx.doi.org/10.1183/13993003.00439-2019.

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We evaluated the effect of gefapixant on cough reflex sensitivity to evoked tussive challenge.In this phase 2, double-blind, two-period study, patients with chronic cough (CC) and healthy volunteers (HV) were randomised to single-dose gefapixant 100 mg or placebo in a crossover fashion. Sequential inhalational challenges with ATP, citric acid, capsaicin and distilled water were performed 1, 3 and 5 h after dosing. Mean concentrations evoking ≥2 coughs (C2) and ≥5 coughs (C5) post dose versus baseline were co-primary endpoints. Objective cough frequency (coughs·h−1) over 24 h and a cough severi

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Fraser, Simon D., Susannah Thackray-Nocera, Marica Shepherd, et al. "Azithromycin for sarcoidosis cough: an open-label exploratory clinical trial." ERJ Open Research 6, no. 4 (2020): 00534–2020. http://dx.doi.org/10.1183/23120541.00534-2020.

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BackgroundChronic cough is a distressing symptom for many people with pulmonary sarcoidosis. Continuous treatment with a macrolide antibiotic may improve cough. We aimed to assess the potential efficacy of azithromycin in patients with sarcoidosis and self-reported cough.MethodsWe conducted a noncontrolled, open-label clinical trial of azithromycin 250 mg once daily for 3 months in patients with pulmonary sarcoidosis who reported a chronic cough. The primary outcome was number of coughs in 24 h. Secondary outcomes were cough visual analogue scales and quality of life measured using the Leicest

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Eni, Marina, Valeria Mordoh, and Yaniv Zigel. "Cough detection using a non-contact microphone: A nocturnal cough study." PLOS ONE 17, no. 1 (2022): e0262240. http://dx.doi.org/10.1371/journal.pone.0262240.

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An automatic non-contact cough detector designed especially for night audio recordings that can distinguish coughs from snores and other sounds is presented. Two different classifiers were implemented and tested: a Gaussian Mixture Model (GMM) and a Deep Neural Network (DNN). The detected coughs were analyzed and compared in different sleep stages and in terms of severity of Obstructive Sleep Apnea (OSA), along with age, Body Mass Index (BMI), and gender. The database was composed of nocturnal audio signals from 89 subjects recorded during a polysomnography study. The DNN-based system outperfo

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Xu, Xuhai, Ebrahim Nemati, Korosh Vatanparvar, et al. "Listen2Cough." Proceedings of the ACM on Interactive, Mobile, Wearable and Ubiquitous Technologies 5, no. 1 (2021): 1–22. http://dx.doi.org/10.1145/3448124.

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The prevalence of ubiquitous computing enables new opportunities for lung health monitoring and assessment. In the past few years, there have been extensive studies on cough detection using passively sensed audio signals. However, the generalizability of a cough detection model when applied to external datasets, especially in real-world implementation, is questionable and not explored adequately. Beyond detecting coughs, researchers have looked into how cough sounds can be used in assessing lung health. However, due to the challenges in collecting both cough sounds and lung health condition gr

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Aksu, Esra Arslan, and Oğuz Uzun. "Determining Chronic Cough Using the Methacholine Bronchial Provocation Test." Jurnal Respirasi 11, no. 1 (2025): 1–5. https://doi.org/10.20473/jr.v11-i.1.2025.1-5.

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Introduction: Chronic cough is a common symptom in pulmonology outpatient clinics, often associated with lung conditions, though extrapulmonary causes can also be responsible. This study aimed to detect bronchial hyperreactivity (BHR) and cough-variant asthma using a methacholine bronchial provocation test (BPT) in patients with chronic cough for whom standard diagnostic procedures could not identify a cause. Methods: This prospective study evaluated patients admitted to the clinic who presented with chronic coughs over one year. A BPT was performed on patients for whom standard diagnostic pro

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Keen, Eric M., Emily J. True, Alyssa R. Summers, Everett Clinton Smith, Joe Brew, and Simon Grandjean Lapierre. "High-throughput digital cough recording on a university campus: A SARS-CoV-2-negative curated open database and operational template for acoustic screening of respiratory diseases." DIGITAL HEALTH 8 (January 2022): 205520762210975. http://dx.doi.org/10.1177/20552076221097513.

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Objective Respiratory illnesses have information-rich acoustic biomarkers, such as cough, that can potentially play an important role in screening populations for disease risk. To realize that potential, datasets of paired acoustic-clinical samples are needed for the development and validation of acoustic screening models, and protocols for collecting acoustic samples must be efficient and safe. We collected cough acoustic signatures at a high-throughput SARS-CoV-2 testing site on a college campus. Here, we share logistical details and the dataset of acoustic cough signatures paired with the g

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Donnelly, Deirdre, and Mark L. Everard. "‘Dry’ and ‘wet’ cough: how reliable is parental reporting?" BMJ Open Respiratory Research 6, no. 1 (2019): e000375. http://dx.doi.org/10.1136/bmjresp-2018-000375.

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IntroductionChronic cough in childhood is common and causes much parental anxiety. Eliciting a diagnosis can be difficult as it is a non-specific symptom indicating airways inflammation and this may be due to a variety of aetiologies. A key part of assessment is obtaining an accurate cough history. It has previously been shown that parental reporting of ‘wheeze’ is frequently inaccurate. This study aimed to determine whether parental reporting of the quality of a child’s cough is likely to be accurate.MethodsParents of 48 ‘new’ patients presenting to a respiratory clinic with chronic cough wer

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Martinek, Jozef, P. Klco, M. Vrabec, T. Zatko, M. Tatar, and M. Javorka. "Cough Sound Analysis." Acta Medica Martiniana 13, Supplement-1 (2013): 15–20. http://dx.doi.org/10.2478/acm-2013-0002.

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Abstract Cough is the most common symptom of many respiratory diseases. Currently, no standardized methods exist for objective monitoring of cough, which could be commercially available and clinically acceptable. Our aim is to develop an algorithm which will be capable, according to the sound events analysis, to perform objective ambulatory and automated monitoring of frequency of cough. Because speech is the most common sound in 24-hour recordings, the first step for developing this algorithm is to distinguish between cough sound and speech. For this purpose we obtained recordings from 20 hea

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Dipali, Chaudhari* Khushi Patil Jagruti Wankhede Saeed Ahmed Shaikh Habiburrahman. "A Comprehensive Review on The Formulation and Evaluation of Herbal Cough Syrup." International Journal of Pharmaceutical Sciences 3, no. 1 (2025): 1094–103. https://doi.org/10.5281/zenodo.14644399.

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The most common problem suffered by individuals everywhere over many centuries cough. Coughing is the protective mechanism of the body. Coughs are classified further accordingly which are depending upon factors such as signs and symptoms, duration, type, character, etc. Most commonly used, prepared and popular dosage form to cure cough and cold is syrup. The most preferred dosage form to cure cough is herbal syrup, which is used mostly due its benefits over synthetic syrups. Medicinal plants are used as primary health care agents, mostly in Asian countries. Ingredients showing expectorant anti

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Ikawati, Zullies, Poppy Firzani Arifin, Severinus Nugraha Krisma Sandy, Raphael Aswin Susilowidodo, and Rosalina Wisastra. "Antitussive Activity of Herbal Cough Medicine on Guinea Pigs (Cavia porvellus)." Majalah Obat Tradisional 26, no. 1 (2021): 59. http://dx.doi.org/10.22146/mot.56620.

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This study aims to investigate the antitussive activity of herbal cough medicine containing combined herbal extracts of Echinacea purpurea, Sambucus nigra (Black Elderberry), Glycyrrhiza glabra (licorice), Vitex trifolia (Indian wild pepper), and Zingiber officinale (ginger). Antitussive assays were conducted on male Dunkin-Hartley albino guinea pigs (Cavia cobaya), which are divided into 5 groups, each with 8 individuals. These 5 groups were assigned for negative control group (treated with CMC-Na 0.5%), a positive control group (treated with Dextromethorphan 20 mg/kg BW), and three groups re

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Ebihara, Takae, Peijun Gui, Chika Ooyama, Koichi Kozaki, and Satoru Ebihara. "Cough reflex sensitivity and urge-to-cough deterioration in dementia with Lewy bodies." ERJ Open Research 6, no. 1 (2020): 00108–2019. http://dx.doi.org/10.1183/23120541.00108-2019.

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Cough, an important respiratory symptom, predominantly involves the brainstem and the urge-to-cough (UTC) is modulated by the cerebral cortex. Lewy body disease is associated with decreased cough reflex sensitivity and central respiratory chemosensitivity. Additionally, the insula, associated with the UTC, shows decreased activation and atrophy in dementia with Lewy bodies (DLB). We investigated the relationships between cognition and cough reflex and the UTC and compared the differences in responses of patients with DLB and other dementia subtypes.We conducted a cross-sectional study within a

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Xiang, Anbo, Yoshiyuki Uchida, Akihiro Nomura, et al. "Involvement of thromboxane A2 in airway mucous cells in asthma-related cough." Journal of Applied Physiology 92, no. 2 (2002): 763–70. http://dx.doi.org/10.1152/jappl.2002.92.2.763.

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The aim of this study was to elucidate the role of thromboxane A2 (TxA2) on asthma-related cough in guinea pigs. Animals were immunosensitized and repeatedly challenged with ovalbumin as an antigen. Coughs were induced by the inhalation of 10−5 M capsaicin solution for 10 min. Thromboxane synthetase (TxS) inhibitor OKY-046 and thromboxane-receptor antagonist AA-2414 significantly inhibited cough responses in repeatedly challenged animals. Inhalation of TxA2 mimic STA-2- potentiated cough responses in normal and immunosensitized animals but not in repeatedly challenged ones. Moreover, STA-2-pot

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Bolser, D. C. "Fictive cough in the cat." Journal of Applied Physiology 71, no. 6 (1991): 2325–31. http://dx.doi.org/10.1152/jappl.1991.71.6.2325.

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Experiments were performed to determine whether cough could be elicited in paralyzed cats ventilated on a respiratory cycle-triggered pump. Midcollicular decerebrate cats were paralyzed and artificially ventilated on a phrenic-triggered pump. Phrenic and cranial iliohypogastric nerve efferent activities were recorded. Cough was elicited by electrical stimulation of the superior laryngeal nerve (SLN) or probing the intrathoracic trachea. Fictive coughs induced by electrical stimulation of the SLN or mechanical stimulation of the intrathoracic trachea consisted of large-amplitude bursts in phren

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Galvosas, Mindaugas, Juan C. Gabaldón-Figueira, Eric M. Keen, et al. "Performance evaluation of the smartphone-based AI cough monitoring app - Hyfe Cough Tracker against solicited respiratory sounds." F1000Research 11 (June 9, 2023): 730. http://dx.doi.org/10.12688/f1000research.122597.2.

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Background: Emerging technologies to remotely monitor patients’ cough show promise for various clinical applications. Currently available cough detection systems all represent a trade-off between convenience and performance. The accuracy of such technologies is highly contingent on the clinical settings in which they are intended to be used. Moreover, establishing gold standards to measure this accuracy is challenging. Objectives: We present the first performance evaluation study of the Hyfe Cough Tracker app, a passive cough monitoring smartphone application. We evaluate performance for cough

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Majumder, Samir C., MA Hossain, MR Hasan, et al. "Aetiological Approach to Patient with Non- Specific Chronic Cough." TAJ: Journal of Teachers Association 25 (November 28, 2018): 1–7. http://dx.doi.org/10.3329/taj.v25i0.37549.

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Chronic cough is a problem commonly encountered by the practicing physicians. Definitive treatment depends upon identifying the cause of cough4.To develop an appropriate algorithm for diagnosis of non-specific chronic cough a Prospective case-control study was carried out in Asthma Centre,NIDCH, Mohakhali, Dhaka during the period of January,2000 to December,2001. Eighty two patients with history of cough for 3 weeks or more duration were taken in group A.The ages ranged from 11 to 68 years with mean age 35.5 ± 12.0 years. There were 43 males and 39 females. Equal number of subjects having no c

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Lin, Kwan-Hwa, Yih-Loong Lai, Huey-Dong Wu, Tyng-Quey Wang, and Yen-Ho Wang. "Cough Threshold in People With Spinal Cord Injuries." Physical Therapy 79, no. 11 (1999): 1026–31. http://dx.doi.org/10.1093/ptj/79.11.1026.

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Abstract Background and Purpose. The purpose of this study was to compare the cough threshold between people with and without spinal cord injury (SCI). The effect of smoking on cough threshold was also investigated. Subjects. The participants were 26 people with SCI (15 smokers, 11 nonsmokers) and 18 people without SCI (9 smokers, 9 nonsmokers). Methods. Aerosols of citric acid were delivered with incremental doubling concentration from 62.5 mmol to 2 mol. Cough threshold was defined as the first concentration of citric acid that induced at least 2 coughs, which is associated with large chest

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