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Journal articles on the topic 'Coumarin derivative'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Min, Su Ji, Heesu Lee, Myoung-Sook Shin, and Jae Wook Lee. "Synthesis and Biological Properties of Pyranocoumarin Derivatives as Potent Anti-Inflammatory Agents." International Journal of Molecular Sciences 24, no. 12 (2023): 10026. http://dx.doi.org/10.3390/ijms241210026.

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This study aimed to synthesize 23 coumarin derivatives and analyze their anti-inflammatory effects on lipopolysaccharide (LPS)-induced inflammation in RAW264.7 macrophages. A cytotoxicity test performed on LPS-induced RAW264.7 macrophages revealed that none of the 23 coumarin derivatives were cytotoxic. Among the 23 coumarin derivatives, coumarin derivative 2 showed the highest anti-inflammatory activity by significantly reducing nitric oxide production in a concentration-dependent manner. Coumarin derivative 2 inhibited the production of proinflammatory cytokines, including tumor necrosis fac

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2

Al-Harbi, Reem A. K. "Synthesis of New Coumarin Scaffold Bearing 2-Iminochromene Moiety." Acta Chimica Slovenica 70, no. 3 (2023): 380–84. http://dx.doi.org/10.17344/acsi.2023.8016.

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Coumarin is classified as one of interesting therapeutic starting research points to obtain remarkable compounds with high efficacy. So, during this research, new 2-iminochromene derivatives bearing coumarin moiety were synthesized. At first, cyanoacetohydrazone of 3-acetylcoumarin was prepared and used as the starting material. The 2-iminochromene derivatives were synthesized through the ring closure of cyanoacetohydrazone derivative with 4-hydroxysalicylaldehyde, 5-aryldiazosalicylaldehydes, 2-hydroxynaphthaldehyde and 7-hydroxychromone-6-carboxaldehyde derivative. All of the newly synthesiz

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3

Sanaryh Mohammed Al-awad, Leaqaa Abdalredha raheem, and Ausama Ayob Jaccob. "Synthesis and Pharmacological Evaluation of Novel Coumarin Derivatives." International Journal of Research in Pharmaceutical Sciences 11, no. 1 (2020): 865–74. http://dx.doi.org/10.26452/ijrps.v11i1.1908.

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The current work focuses on new architecture, synthesis of coumarin-oxadiazole hybrid derivative products as both these (coumarin ring and oxadiazole) have a wide variety of biological behavior, Compounds containing the nucleus of coumarin (2H-1-benzopyran-2-one) are an interesting class of hetero cycles which hold an important role in the field of natural ingredients and synthetic organic chemistry. It has been exciting medicinal chemists to study native coumarins or synthetic analogs for their application for decades. And they can be further modified to synthesize more effective and potent d

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4

Kumari, Sumita, Amit Sharma, and Sonia Yadav. "Pharmacological Potential of Coumarin-Based Derivatives: (A Comprehensive Brief Review)." Oriental Journal Of Chemistry 39, no. 3 (2023): 568–76. http://dx.doi.org/10.13005/ojc/390304.

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By combining of benzene nucleus and pyrone ring a class of heterocyclic compounds known as benzopyrone is generated. As a basic parent scaffold 1,2- benzopyrone ring system contains by coumarins. These compounds can be divided into two groups: 1. Benzo-α-pyrone 2. Benzo-γ-pyrone. Data on different coumarin derivatives are gathered in this review article as these compounds have a wide spectrum of pharmacological actions and can be further modified to make more potent and effective medications. Derivatives of coumarin play a significant role in industries and sectors of medicine. This can be lin

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5

Hwang, Sumi. "Antibacterial Activity for Synthesized Coumarin Derivatives and a Coumarin Component of Lime Peel (Citrus aurantifolia)." Bioengineering 11, no. 8 (2024): 752. http://dx.doi.org/10.3390/bioengineering11080752.

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In this study, we investigated the antibacterial activity of the coumarin component isolated from lime peel and coumarin derivatives synthesized using various techniques against eight types of food-poisoning bacteria. The minimum inhibitory concentration (MIC) for the 3b [5,7-dihydroxy-4-trifluoromethylcoumarin] derivative was measured as 1.5 mM in Bacillus cereus, Micrococcus luteus, Listeria monocytogenes, and Staphylococcus aureus subsp. aureus; that for the 3c [7-hydroxy-4-trifluoromethylcoumarin] derivative was 1.7 mM in Enterococcus facium; and that for the 3n [dicoumarol] derivative was

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6

Kashirin, Anton O., Irina B. Krylova, Elena N. Selina, et al. "Antihypoxic effect of new synthetic derivatives of 7-alkoxycoumarin and 4-aminocoumarin in acute hypobaric hypoxia in rats." Reviews on Clinical Pharmacology and Drug Therapy 19, no. 4 (2021): 413–20. http://dx.doi.org/10.17816/rcf194413-420.

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BACKGROUND: Coumarins are naturally occurring molecules with a wide range of pharmacological activities. Their use is limited by difficulties in isolation from plant material, toxicity, and low solubility. The chemical structure of these compounds makes coumarins promising for the synthesis of a large number of derivatives that may have biological activity and be of interest as potential drugs. We had synthesized coumarin derivatives, two of which IEM-2266 (7-alkoxycoumarin derivative) and IEM-2267 (4-aminocoumarin derivative) have shown antihypoxic effect in mice in models of hypoxic hypoxia

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7

Gümüş, Hacer. "Evaluation of the Antioxidant Properties of Coumarin Derivatives Using Spectroscopic Methods." Clinical Cardiology and Cardiovascular Interventions 7, no. 10 (2024): 01–06. https://doi.org/10.31579/2641-0419/399.

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Coumarin derivatives are perceived as part of defense mechanisms in plants due to their commonly observed antimicrobial, antioxidant, antitumor, anti-inflammatory, and other biological activities. Investigating the molecular structure of coumarin derivatives using computational programs like Gaussian is an effective method for understanding the biological, chemical, and physical properties of these compounds. Therefore, in this study, the molecular structure parameters and spectroscopic (IR, NMR) properties of our coumarin derivative compound were theoretically examined using the DFT method wi

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U., C. Mashelkar, and A. Audi A. "Synthesis of some novel 4-substituted coumarins having antibacterial activity (Part-I)." Journal of Indian Chemical Society Vol. 82, Mar 2005 (2005): 254–57. https://doi.org/10.5281/zenodo.5827011.

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Organic Research Laboratory. SS & LS Patkar College, Goregaon (W). Mumbai-400 062, India E-mail: ajayaaudi@rediffmail.com                                                        Fax : 91-22-28744755 <em>Manuscript received 13 February 2004, revised 1 September 2004, accepted 24 November 2004</em> Methyl coumarin-4-methyl acetate on bromination in dioxane or dichloroethane as solvent resulted in sidechain bromination giving a-bromo derivative. The same r

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9

Adeleke, Richard, Idayat Sulaıman, Sunday Wilson Balogun, Wahab Osunniran, Sikiru Ahmed, and Olusola James. "Computational Studies of Suitability of Triarylmethane-Coumarins as Sensitizer for Dye-Sensitized Solar Cells." Turkish Computational and Theoretical Chemistry 8, no. 3 (2024): 66–73. http://dx.doi.org/10.33435/tcandtc.1349520.

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Triarylmethanes are low cost synthetic dyes with intense absorption in the visible spectrum. This make it attractive to explore their suitability as sensitizer for dye sensitized solar cell. Using malachite green as a lead dye, we made intuitive structural modifications: incorporation of coumarin-3-carboxylic acid as acceptor/anchor, and substituting one or the two N, N-diethylaniline donors with N-propyl-1,6dimethyllutidine(s). The three resulting triarylmethane-coumarin structures were subjected to DFT calculations to investigate their suitability as sensitizers for DSSC applications. The ca

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10

Szafraniec, Anna, and Waldemar Iwanek. "Intramolecular Hydrogen Bond Driven Conformational Selectivity of Coumarin Derivatives of Resorcin[4]arene." International Journal of Molecular Sciences 21, no. 17 (2020): 6160. http://dx.doi.org/10.3390/ijms21176160.

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In this study, the synthesis and structure of 4-aminocoumarin derivatives of resorcin[4]arene were investigated. Spectroscopic analysis and quantum mechanical calculations showed that this molecule undertakes a crown-in conformation in chloroform. The conformations of the aminocoumarin derivative of resorcin[4]arene were compared with a hydroxycoumarin derivative of resorcin[4]arene, and the effect of the substituent on the conformational selectivity of the coumarin derivatives of resorcin[4]arene was demonstrated. Both UV-VIS and fluorescence spectroscopy for the coumarin derivative of resorc

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11

Yoon, Jeong A., and Young Taek Han. "Efficient Synthesis of Pyrido[3,2-c]coumarins via Silver Nitrate Catalyzed Cycloisomerization and Application to the First Synthesis of Polyneomarline C." Synthesis 51, no. 24 (2019): 4611–18. http://dx.doi.org/10.1055/s-0037-1610730.

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Herein, we report an efficient method for the synthesis of the pyrido[3,2-c]coumarin scaffold, one of the privileged heterocycle-fused coumarin scaffolds, via a AgNO3-catalyzed cycloisomerization of 4-(propynylamino)coumarins obtained from diverse 4-hydroxycoumarins. This concise method affords pyrido[3,2-c]coumarin analogues bearing diverse substituents on the benzene or pyridine ring in moderate to good yields. Moreover, this methodology was extended to the facile synthesis of polyneomarline C, a natural pyrido[3,2-c]coumarin derivative isolated from the Chinese herbal medicine Polyalthia ne

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12

Alshibl, Hanan M., Ebtehal S. Al-Abdullah, Mogedda E. Haiba, et al. "Synthesis and Evaluation of New Coumarin Derivatives as Antioxidant, Antimicrobial, and Anti-Inflammatory Agents." Molecules 25, no. 14 (2020): 3251. http://dx.doi.org/10.3390/molecules25143251.

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New pyranocoumarin and coumarin-sulfonamide derivatives were prepared and evaluated for their antioxidant, antimicrobial, and/or anti-inflammatory activities. Coumarin-sulfonamide compounds 8a–d demonstrated significant antioxidant activity, while 7c,d, 8c,d, and 9c,d exhibited antimicrobial activity equal to or higher than the standard antimicrobials against at least one tested microorganism. Regarding the anti-inflammatory testing, pyranocoumarins 2b, 3a,b and 5c and coumarin-sulfonamide compound 9a showed more potent antiproteinase activity than aspirin in vitro; however, five compounds wer

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13

Shao, Jiaan, Wenteng Chen, Di Ke, Ke Shu, En Chen, and Yongping Yu. "Highly Efficient Synthesis of Polysubstituted 2-Aminopyrroles via a Multicomponent Domino Reaction." Synlett 29, no. 07 (2018): 922–27. http://dx.doi.org/10.1055/s-0036-1591907.

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A highly efficient approach to polysubstituted 2-aminopyrroles containing a coumarin derivative unit at the 5-position of the pyrrole ring was developed via a novel multicomponent domino reaction of glyoxal monohydrate derivatives, anilines, coumarin derivatives, and malononitrile. This transformation proceeded via an α-aminoketone as the key intermediate.

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Jelali, Hamida, A. Chakchouk-Mtibaa, Lasaad Baklouti, et al. "Development of New Multicomponent Reactions in Eco-Friendly Media-Greener Reaction and Expeditious Synthesis of Novel Bioactive Benzylpyranocoumarins." Journal of Chemistry 2019 (August 21, 2019): 1–10. http://dx.doi.org/10.1155/2019/8693614.

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Multicomponent cyclocondensation of hydrazine derivatives, ethyl acetoacetate, aromatic aldehydes, and 4-hydroxycoumarin has been reported. The optimization details of the developed novel protocol are recorded. The novel procedure features short reaction time, moderate yields, and simple workup. In addition, BMIM[triflate] was chosen as a green solvent. The structures of the obtained benzylpyrazolyl coumarins were determined and confirmed by 1H NMR, 13C NMR, IR, and elemental analysis. The MIC values of benzylpyrazolyl coumarin derivatives were determined by the microbroth dilution method usin

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15

Kapidou, Eleni, and Konstantinos E. Litinas. "An Overview of the Synthesis of 3,4-Fused Pyrrolocoumarins of Biological Interest." Molecules 29, no. 12 (2024): 2748. http://dx.doi.org/10.3390/molecules29122748.

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3,4-Fused pyrrolocoumarins, synthetically prepared or naturally occurring, possess interesting biological properties. In this review, the synthetic strategies for the synthesis of the title compounds are presented along with their biological activities. Two routes are followed for that synthesis. In one, the pyrrole ring is formed from coumarin derivatives, such as aminocoumarins or other coumarins. In the other approach, the pyranone moiety is built from an existing pyrrole derivative or through the simultaneous formation of coumarin and pyrrole frameworks. The above syntheses are achieved vi

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Patil, Shashank M., Reshma Mary Martiz, A. M. Satish та ін. "Discovery of Novel Coumarin Derivatives as Potential Dual Inhibitors against α-Glucosidase and α-Amylase for the Management of Post-Prandial Hyperglycemia via Molecular Modelling Approaches". Molecules 27, № 12 (2022): 3888. http://dx.doi.org/10.3390/molecules27123888.

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Coumarin derivatives are proven for their therapeutic uses in several human diseases and disorders such as inflammation, neurodegenerative disorders, cancer, fertility, and microbial infections. Coumarin derivatives and coumarin-based scaffolds gained renewed attention for treating diabetes mellitus. The current decade witnessed the inhibiting potential of coumarin derivatives and coumarin-based scaffolds against α-glucosidase and α-amylase for the management of postprandial hyperglycemia. Hyperglycemia is a condition where an excessive amount of glucose circulates in the bloodstream. It occur

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17

Journal, Baghdad Science. "Synthesis and Characterization of New Mannich Bases Derived from 7-hydroxy-4-methyl Coumarin." Baghdad Science Journal 13, no. 2 (2016): 235–43. http://dx.doi.org/10.21123/bsj.13.2.235-243.

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Coumarin is a natural substance isolated from different plants. It belonges to a group of benzobyrones which consists of a benzene ring joined to a pyrone nucleus. In the present research, a new series of coumarin derivatives were formed. Compound (1) (7-hydroxy-4-methyl Coumarin) was converted into 4-methylquinolin-2(H) derivative (2) by reaction with acetamide, and then reaction of (2) with thiosemicarbazide in ethanol leads to the synthesize of hydrazincarbothioamide derivative (3).The reaction of (3) with ethylchloroacetate in presence of sodium acetate leads to closure ring to get [(1-(5-

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18

Michalska, Marta, Wojciech Pajak, Justyna Kołodziejska, Andrzej Lazarenkow, and Jolanta Nawrot-Modranka. "Influence of phosphorohydrazone derivatives of benzopyrones on polymerization and viscosity of fibrin." Acta Biochimica Polonica 55, no. 3 (2008): 613–17. http://dx.doi.org/10.18388/abp.2008_3068.

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The synthesis and antitumour and antibacterial activity of coumarin and chromone phosphorohydrazones have been reported. This study describes influence of phosphorohydrazones derivatives of coumarin and chromone on the polymerization and viscosity of fibrin. The fibrin polymerization assay was performed by the Shen and Lorand method and the clot viscosity was measured on the basis of Shen and Lorand and Marchi and coworkers methods. Among the eight compounds tested, one coumarin derivative and two chromone derivatives showed significant activity.

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19

K. N, Chethan Prathap, Niranjana S. V, and Lokanath N. K. "Synthesis, characterization, structural exploration and quantum chemical calculations of (E)-8-(1-((4-aminobenzyl)imino)ethyl)-7-hydroxy-4-methyl-coumarin." Oriental Journal Of Chemistry 37, no. 2 (2020): 484–92. http://dx.doi.org/10.13005/ojc/370231.

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Coumarin derivatives are one of the very important compounds of high biological interest. A novel coumarin derivative (E)-8-(1-((4-aminobenzyl)imino)ethyl)-7-hydroxy-4-methyl-coumarin was synthesized using substituted acetyl coumarin and 4-aminobenzylamine. Following the detailed spectroscopic characterization, the structure of the compound was confirmed using XRD studies. The novel coumarin derivative crystallizes in monoclinic crystal system in P21/c space group and displays diverse intermolecular interactions. One-dimensional array along b-axis and R_2^2 (18) supramolecular architectures ar

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Tataringa, Gabriela, Balasubramanian Sathyamurthy, Ion Sandu, and Ana Maria Zbancioc. "In silico Docking Study of Some Coumarin Derivatives as Potential Inhibitors on Different Dengue Viral Proteins." Revista de Chimie 70, no. 9 (2019): 3387–91. http://dx.doi.org/10.37358/rc.19.9.7555.

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In this study, the binding efficiency of 10 coumarin derivatives with some selected proteins from Dengue virus through in silico method was done. By virtual screening and docking results, we have found that the hybrid derivative between coumarin and isatin has the most convenient binding activity for the seven selected proteins.

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Bedair, A. H., Abd El-Wahab, A. M. El-Agrody, F. M. Ali, A. H. Halawa, and G. M. El-Sherbiny. "Binary heterocyclic systems containing the ethylideneamino linkage: synthesis of some new heterocyclic compounds bearing the naphtho-[2,1-b]furan moiety." Journal of the Serbian Chemical Society 71, no. 5 (2006): 459–69. http://dx.doi.org/10.2298/jsc0605459b.

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Ethylidene hydrazine (4a,b) and thiazolidin-4-one (5) derivatives were synthesized by the reaction of ethylidenethiosemicarbazide derivative (3a) with ?-haloketone/ethyl bromoacetate, respectively. Hetrocyclization of ethylideneacetohydrazide derivative (7) with o-phenolic aldehydes gave the corresponding coumarin derivatives (8,9). The interaction of 7 with acetylacetone afforded the corresponding pyridine derivative (10). Treatment of the arylidene derivative 11b with malononitrile afforded the corresponding pyran derivative (12). The new products 3-12 were subjected to IR, 1H NMR and mass s

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Jalhan, Sunny. "Review Article: Various Biological Activities of Coumarin and Oxadiazole Derivatives." Asian Journal of Pharmaceutical and Clinical Research 10, no. 7 (2017): 38. http://dx.doi.org/10.22159/ajpcr.2017.v10i7.18461.

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In this review article data is collected regarding the various derivatives of coumarin and oxadiazole as both these have wide range of biological activities and they can be further modified to synthesize more effective and potent drugs. Coumarin class of organic compounds consists of 1,2-benzopyrone ring system as a basic parent scaffold. These benzopyrones are subdivided into alpha-benzopyrones and gamma benzopyrones; with coumarin class of compounds belonging to alpha-benzopyrones. Since the last few years, coumarins were synthesized in many of their derivative forms. Their pharmacological,

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23

Justus, Eugen, Dana T. Izteleuova, Alexander V. Kasantsev, Mendel M. Axartov, Enno Lork, and Detlef Gabel. "Preparation of Carboranyl and Dodecaborate Derivatives of Coumarin." Collection of Czechoslovak Chemical Communications 72, no. 12 (2007): 1740–54. http://dx.doi.org/10.1135/cccc20071740.

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A series of derivatives of coumarin (2H-chromen-2-one) and 6,7-benzocoumarin (3H-benzo-[f]chromen-3-one) carrying the o-carborane, m-carborane, and dodecaborate clusters, has been obtained. X-ray structure analysis has been carried out for three of the products. The addition of o-carborane occurs in the 4-position of the coumarin ring, in a stereoselective way, independent of whether the cluster was reacted as the lithium or magnesium salt. m-Carborane gives two products, one being the result of 1,2-addition to an exocyclic ester bond and 1,4-addition to the coumarin system, the other resultin

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Lu, Ping-Hsun, Tzu-Hsien Liao, Yau-Hung Chen, et al. "Coumarin Derivatives Inhibit ADP-Induced Platelet Activation and Aggregation." Molecules 27, no. 13 (2022): 4054. http://dx.doi.org/10.3390/molecules27134054.

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Coumarin was first discovered in Tonka bean and then widely in other plants. Coumarin has an anticoagulant effect, and its derivative, warfarin, is a vitamin K analogue that inhibits the synthesis of clotting factors and is more widely used in the clinical treatment of endovascular embolism. At present, many artificial chemical synthesis methods can be used to modify the structure of coumarin to develop many effective drugs with low toxicity. In this study, we investigated the effects of six coumarin derivatives on the platelet aggregation induced by adenosine diphosphate (ADP). We found that

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Zaki Rashed, Khaled Nabih. "Biological Evidences of Dicoumarol: A Review." Plantae Scientia 4, no. 2 (2021): 121–24. http://dx.doi.org/10.32439/ps.v4i2.121-124.

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Dicoumarol, a natural anticoagulant drug chemically designated as is metabolized from coumarin in the sweet clover (Melilotus alba and Melilotus officinalis) by molds, such as Penicillium nigricans and Penicillium jensi. Coumarin (1,2-benzopyrone), the parent molecule of dicoumarol, is the simplest compound of a large class of naturally occurring phenolic substances made of fused benzene and pyrone rings . In addition, the coumarin anticoagulants, dicoumarol (Dicumarol) and its synthetic derivative warfarin sodium (Coumadin), have been shown to decrease metastases in experimental animals. Warf

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Ariefin, Mokhamat, and Rokiy Alfanaar. "Molecular Modelling Based on TD-DFT Applied to UV Spectra of Coumarin Derivatives." Walisongo Journal of Chemistry 6, no. 1 (2023): 61–68. http://dx.doi.org/10.21580/wjc.v6i1.15696.

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The optimization of geometry and electronic transition of seven coumarin derivatives for sunscreen activity have been conducted using Orca. DFT methods is applied to find optimum geometry and parameter data is measured like bond length and bond angle. TD-DFT is conducted to get electronic transition to get ultraviolet (UV) spectra. The result shows that the coumarin derivative transition type is n to π* and π to π*. All coumarin exhibits the properties of UV-B protection, however, two out of seven show properties as a UV-A protection. The energy difference HOMO-LUMO shows that coumarin with is

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Guo, Zili, Jinping Gu, Miao Zhang, Feng Su, Weike Su, and Yuanyuan Xie. "NMR-Based Metabolomics to Analyze the Effects of a Series of Monoamine Oxidases-B Inhibitors on U251 Cells." Biomolecules 13, no. 4 (2023): 600. http://dx.doi.org/10.3390/biom13040600.

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Alzheimer’s disease (AD) is a typical progressive neurodegenerative disorder, and with multiple possible pathogenesis. Among them, coumarin derivatives could be used as potential drugs as monoamine oxidase-B (MAO-B) inhibitors. Our lab has designed and synthesized coumarin derivatives based on MAO-B. In this study, we used nuclear magnetic resonance (NMR)-based metabolomics to accelerate the pharmacodynamic evaluation of candidate drugs for coumarin derivative research and development. We detailed alterations in the metabolic profiles of nerve cells with various coumarin derivatives. In total,

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Brahmia, Ameni, Riadh Marzouki, Jan Rohlicek, Ahmad Irfan, Abdullah G. Al-Sehemi, and Rached Ben Hassen. "Structural, spectroscopic and first-principles studies of new aminocoumarin derivatives." Acta Crystallographica Section C Structural Chemistry 75, no. 12 (2019): 1617–27. http://dx.doi.org/10.1107/s2053229619012993.

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The new aminocoumarin derivatives 3-[1-(3-hydroxyanilino)ethylidene]-3H-chromene-2,4-dione, (1), 3-[1-(4-hydroxyanilino)ethylidene]-3H-chromene-2,4-dione, (2), and 3-[1-(2-hydroxyanilino)ethylidene]-3H-chromene-2,4-dione, (3), all C17H13NO4, were synthesized by reacting an equimolar amount of 3-acetyl-4-hydroxycoumarin and the corresponding aminophenol in absolute ethanol. Structural and spectroscopic analysis of these phases revealed that derivatives (1) and (2) are isomers of previously reported (3) [Brahmia et al. (2013). Acta Cryst. E69, o1296]. The crystal structures of meta derivative (1

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Muttaqin, Fauzan Zein, Taufik Muhammad Fakih, and Hubbi Nashrullah Muhammad. "MOLECULAR DOCKING, MOLECULAR DYNAMICS, AND IN SILICO TOXICITY PREDICTION STUDIES OF COUMARIN, N-OXALYLGLYCINE, ORGANOSELENIUM, ORGANOSULFUR, AND PYRIDINE DERIVATIVES AS HISTONE LYSINE DEMETHYLASE INHIBITORS." Asian Journal of Pharmaceutical and Clinical Research 10, no. 12 (2017): 212. http://dx.doi.org/10.22159/ajpcr.2017.v10i12.19348.

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Objective: Prostate cancer is the second most common cancer in men. One of the efforts in the treatment of prostate cancer is by inhibiting histone lysine demethylase. Derivative compounds of coumarine, N-oxalylglycine, organoselenium, organosulfur, and pyridine have been reported to be active against two types of histone lysine demethylase (KDM) enzymes, KDM4E and KDM5B. This study aims to study the interactions of these derivatives with KDM.Methods: In this study, we performed computational studies, including molecular docking and molecular dynamics (MDs) simulations, and toxicity prediction

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Yang, Di, Xiao-Ying He, Xiao-Tian Wu, et al. "A novel mitochondria-targeted ratiometric fluorescent probe for endogenous sulfur dioxide derivatives as a cancer-detecting tool." Journal of Materials Chemistry B 8, no. 26 (2020): 5722–28. http://dx.doi.org/10.1039/d0tb00149j.

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A new mitochondria-targeted fluorescent probe RBC, constructed using a coumarin moiety which was selected as the donor and a benzothiazole derivative as the acceptor, for SO<sub>2</sub> derivatives (HSO<sub>3</sub><sup>−</sup>/SO<sub>3</sub><sup>2−</sup>) was presented.

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Douka, Matina D., and Konstantinos E. Litinas. "An Overview on the Synthesis of Fused Pyridocoumarins with Biological Interest." Molecules 27, no. 21 (2022): 7256. http://dx.doi.org/10.3390/molecules27217256.

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Pyridocoumarins are a class of synthetic and naturally occurring organic compounds with interesting biological activities. This review focuses on the synthetic strategies for the synthesis of pyridocoumarins and presents the biological properties of those compounds. The synthesis involves the formation of the pyridine ring, at first, from a coumarin derivative, such as aminocoumarins, hydroxycoumarins, or other coumarins. The formation of a pyranone moiety follows from an existing pyridine or piperidine or phenol derivative. For the above syntheses, [4 + 2] cycloaddition reactions, multi-compo

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Yu, Chien-Chih, Yi-Ting Chiang, and Thau-Ming Cham. "Identification of the Constituents in Cnidii Fructus Active Against Trichomonas vaginalis Parasites." Dose-Response 20, no. 4 (2022): 155932582211316. http://dx.doi.org/10.1177/15593258221131646.

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Ethanol extracts of Cnidii Fructus, the dried fruits of Cnidium monnieri (L.) Cusson, have been externally applied in the treatment of Trichomonas vaginalis. However, the precise identity of the major constituents responsible for activity against T. vaginalis is unknown, but there is probability they are coumarin derivatives. In this study, the anti- Trichomonas activity of 4 major coumarin derivative constituents of Cnidii Fructus, namely, osthole, xanthotoxin, isopimpinellin, and bergapten, was characterized in terms of the resulting kinetics of growth and morphology of T. vaginalis upon tre

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33

Xu, Wen-Hui, Yun-Heng Shen, Qian Liang, and Ping Zhao. "New coumarin derivative fromEuphorbia wallichii." Natural Product Research 29, no. 19 (2015): 1860–64. http://dx.doi.org/10.1080/14786419.2014.1003930.

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Dekić, Vidoslav, Niko Radulović, Milenko Ristić, Biljana Dekić, and Novica Ristić. "Synthesis and complete NMR spectral assignments of new benzylamino coumarin derivative." Bulletin of Natural Sciences Research 10, no. 2 (2020): 12–16. http://dx.doi.org/10.5937/bnsr10-26133.

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This research involves the reaction of 4-chloro-3-nitrocoumarin and (4-methoxyphenyl)methanamine, whereby a novel coumarin derivative 4-[(4-methoxybenzyl) amino]-3-nitro-2H-chromen-2-one was obtained in good yield. The reaction was carried out in ethyl acetate, in the presence of triethylamine. Also, a detailed spectral analysis of a new coumarin derivative is presented. Resonance assignment was achieved using one( 1H NMR and 13C NMR) and two-dimensional NMR techniques (1H1H-COSY, NOESY, HSQC, and HMBC). The NOESY correlations of protons from arylamino substituent and coumarin core indicate th

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35

Mostafa, Mayy M., and Mohamed A. Farag. "Profiling of primary and phytonutrients in edible mahlab cherry (Prunus mahaleb L.) seeds in the context of its different cultivars and roasting as analyzed using molecular networking and chemometric tools." PeerJ 11 (August 30, 2023): e15908. http://dx.doi.org/10.7717/peerj.15908.

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Prunus mahaleb L. (mahlab cherry) is a deciduous plant that is native to the Mediterranean region and central Europe with a myriad of medicinal, culinary and cosmetic uses. The present study explored different cultivars of mahlab (white from Egypt and Greece, red from Egypt and post roasting). UPLC-MS led to the detection of 110 primary and secondary metabolites belonging to different classes including phenylpropanoids (hydroxy cinnamates, coumaroyl derivatives), organic acids, coumarins, cyanogenic glycosides, flavonoids, nitrogenous compounds, amino acids and fatty acids, of which 39 are fir

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Imit, Mokhtar, Patigul Imin та Alex Adronov. "π-Conjugated polymers with pendant coumarins: design, synthesis, characterization, and interactions with carbon nanotubes". Canadian Journal of Chemistry 94, № 9 (2016): 759–68. http://dx.doi.org/10.1139/cjc-2016-0205.

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A series of new fluorene-based π-conjugated polymers having coumarin derivatives as part of dendritic side chains were designed and prepared using the Suzuki–Miyaura cross-coupling reaction. A new coumarin derivative bearing a heptyl side chain for solubility was utilized to ensure solubility of the final polymers. It was found that fluorescence resonance energy transfer (FRET) from the coumrains to the polyfluorene backbone was efficient, especially for the polymers decorated with lower-generation dendrons. Each of the polymers was found to interact strongly with the surface of single-walled

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37

Sharapov, A. D., R. F. Fatykhov, I. A. Khalymbadzha, A. P. Potapova, P. A. Slepukhin, and O. N. Chupakhin. "Unusual nicotinoylation of 4-phenyl-5,7-dihydroxycoumarin." Chimica Techno Acta 9, no. 1 (2022): 20229105. http://dx.doi.org/10.15826/chimtech.2022.9.1.05.

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In the present work, we report a convenient synthesis of 5- and 7-substituted-4-phenyl coumarins. In contrast to previous results obtained with 4-alkylcoumarins, nicotinoylation of 5,7-dihydroxy-4-phenylcoumarin with nicotinoyl benzotriazole or nicotinoyl azide selectively provides 5-O protected ester. The combination of the nicotinoylation reaction followed by tosylation-denicotinoylation yields 5-hydroxy-7-tosyloxy-coumarin derivative, which may be useful in the synthesis of inophyllum, a tetracyclic HIV reverse transcriptase inhibitor, as well as its analogues.

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Zhang, Jin-Xiu, Jian-Hua Lv, Li-Qiang Zhao, Xiao-Xi Shui, Jun Zhang, and Li-An Wang. "Coumarin-pi, a new antioxidant coumarin derivative from Paxillus involutus." Natural Product Research 34, no. 9 (2019): 1246–49. http://dx.doi.org/10.1080/14786419.2018.1557170.

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Akinyemi, Akintunde, Courtney Thomas, Willis Marsh, Ray J. Butcher, Jerry P. Jasinski, and Lystranne A. Maynard-Smith. "Crystal structures of 4-methyl-2-oxo-2H-chromene-7,8-diyl diacetate and 4-methyl-2-oxo-2H-chromene-7,8-diyl bis(pent-4-ynoate)." Acta Crystallographica Section E Crystallographic Communications 72, no. 5 (2016): 704–8. http://dx.doi.org/10.1107/s2056989016005892.

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In the structures of the two title coumarin derivatives, C14H12O6, (1), and C20H16O6, (2), one with acetate and the other with pent-4-ynoate substituents, both the coumarin rings are almost planar. In (1), both acetate substituents are significantly rotated out of the coumarin plane to minimize steric repulsions. One acetate substituent is disordered over two equivalent conformations, with occupancies of 0.755 (17) and 0.245 (17). In (2), there are two pent-4-ynoate substituents, the C[triple-bond]C group of one being disordered over two positions with occupancies of 0.55 (2) and 0.45 (2). One

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Moi, Davide, Simone Carradori, Marialucia Gallorini, et al. "Investigation on Human Carbonic Anhydrase IX and XII Inhibitory Activity and A549 Antiproliferative Activity of a New Class of Coumarinamides." Pharmaceuticals 18, no. 3 (2025): 372. https://doi.org/10.3390/ph18030372.

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Background—Aggressive solid tumors are commonly characterized by both basic intracellular pH and acidic extracellular pH, which increase cell survival and proliferation. As carbonic anhydrases IX/XII are involved in this pH regulation, their inhibition is an appealing approach in cancer therapy, avoiding cancer cell survival and proliferation. Substituted coumarins are selective non-classical CA IX and CA XII inhibitors. Methods—In this study, new 7-hydroxycoumarinamides were synthesized and assayed for CA inhibition and antiproliferative activity. Results—All of the coumarinamides showed huma

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Beletskaya, Irina, and Victor Desyatkin. "Asymmetric Friedel–Crafts/Michael Reaction of Indoles and Pyrroles with Coumarin-3-carbonylates." Synthesis 49, no. 18 (2017): 4327–34. http://dx.doi.org/10.1055/s-0036-1589024.

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Asymmetric Friedel–Crafts reactions of indoles or pyrroles with coumarin-3-carboxylates catalyzed by Cu(OTf)2 complexes with chiral bis(oxazoline) ligands have been developed. The highest ee (up to 82%) was achieved for indole with a nitro derivative of coumarin-3-carboxylate.

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Wang, Xianfeng, Jingzhou Hou, Xin Shen, Qiang He, Changjun Hou, and Danqun Huo. "Fluorescence-based measurements for the determination of nitrite using a coumarin derivative sensor based on inner filter effect." Analytical Methods 12, no. 8 (2020): 1107–14. http://dx.doi.org/10.1039/c9ay02431j.

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43

Hari, Kant, and Singh Khirwar Mahesh. "Isolation and Characterisation of Coumarin Derivative from Sida rhombifolia Linn." Pharmaceutical and Chemical Journal 9, no. 2 (2022): 30–32. https://doi.org/10.5281/zenodo.13970451.

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A novel coumarin derivative has been isolated from the dichloromethylene fraction of the aerial part of the <em>Sida rhombifolia</em>. The structure of the isolated compound has been established as 7-hydroxy-6-methoxy coumarin based on the spectral (UV, IR, <sup>1</sup>HNMR, <sup>13</sup>CNMR, mass) data.  

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Small, J. V., S. Zobeley, G. Rinnerthaler, and H. Faulstich. "Coumarin-phalloidin: a new actin probe permitting triple immunofluorescence microscopy of the cytoskeleton." Journal of Cell Science 89, no. 1 (1988): 21–24. http://dx.doi.org/10.1242/jcs.89.1.21.

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7-Diethylamino-3-(4-isothiocyanotophenyl)-4-methylcoumarin (CPITC) was coupled to amino-methyldithiolanophalloidin to produce a new phalloidin derivative, coumarin-phalloidin, fluorescent in the blue region of the spectrum. Coumarin-phalloidin binds to actin with around 100-fold less affinity than unconjugated phalloidin, but with enough avidity to make it a useful stain for actin filaments. Appropriate filter combinations permit triple immunofluorescence microscopy of the cytoskeleton with fluorescein and rhodamine conjugates together with coumarin-phalloidin.

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Zhou, Li-Ping, and Ling-Liang Long. "7-Diethylamino-3-{(E)-4-[(E)-2-(pyridin-4-yl)ethenyl]styryl}-2H-chromen-2-one." Acta Crystallographica Section E Structure Reports Online 70, no. 2 (2014): o176. http://dx.doi.org/10.1107/s1600536814001123.

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In the title coumarin derivative, C28H26N2O2, the coumarin unit is approximately planar, with a maximum deviation of 0.048 (3) Å. The central benzene ring is oriented at dihedral angles of 30.15 (14) and 10.51 (11)°, respectively, to the pyridine ring and coumarin ring system. In the crystal, weak C—H...O and C—H...N hydrogen bonds and weak C—H...π interactions link the molecules into a three-dimensional supramolecular architecture.

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46

Chinnathambi, Shanmugavel, Subramani Karthikeyan, Mangaiyarkarsi Rajendiran, et al. "4-Hydroxycoumarin Derivative:N-(diphenylmethyl)-2-[(2-oxo-2H-chromen-4-yl)oxy]acetamide Interaction with Human Serum Albumin." Journal of Spectroscopy 2018 (October 16, 2018): 1–14. http://dx.doi.org/10.1155/2018/3480384.

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In this study, the interaction between the coumarin derivative:N-(diphenylmethyl)-2-[(2-oxo-2H-chromen-4-yl)oxy]acetamide, biologically active drug, and human serum albumin (HSA) was investigated by using various optical spectroscopy techniques along with the computational technique. The results of steady-state fluorescence spectroscopy show that the static quenching occurred while increasing the coumarin drug concentration into HSA. Also, the binding constant (K) and thermodynamical parameters of enthalpy change (ΔH°), entropy change (ΔS°), and Gibbs free energy change (ΔG°) were calculated a

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47

Wei, Peifa, Haoze Wang, Kecheng Jie, and Feihe Huang. "Taco complex-templated highly regio- and stereo-selective photodimerization of a coumarin-containing crown ether." Chemical Communications 53, no. 10 (2017): 1688–91. http://dx.doi.org/10.1039/c6cc10089a.

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We design a coumarin-containing bis(m-phenylene)-32-crown-10 derivative which efficiently controls the regio- and stereo-selectivity of the photodimerization of its two terminal coumarin groups templated by taco-type host–guest complex formation to selectively produce the syn-head-to-tail cryptand isomer in quantitative yield.

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Abdallah, Basem M., Enas M. Ali, Hany Elsawy, Gehan M. Badr, Ashraf M. Abdel-Moneim, and Abdullah M. Alzahrani. "The Coumarin Derivative 5′-Hydroxy Auraptene Suppresses Osteoclast Differentiation via Inhibiting MAPK and c-Fos/NFATc1 Pathways." BioMed Research International 2019 (December 28, 2019): 1–10. http://dx.doi.org/10.1155/2019/9395146.

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The phytochemical substances, coumarin derivatives, have demonstrated antiresorptive bone effects by suppressing osteoclast differentiation in vitro and in vivo. Recently, we have identified 5′-hydroxy auraptene (5′-HA), a coumarin derivative isolated from Lotus lalambensis Schweinf, as a novel stimulator for osteoblast differentiation. In this study, we investigated the effect of 5′-HA on osteoclast differentiation of mouse bone marrow (BM) cells. The effect of 5′-HA on BM cell proliferation and osteoclast differentiation was determined by measuring cell viability and tartrate-resistant acid

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Liu, Mengqiang, Minshan Hu, Qian Jiang, et al. "A novel coumarin derivative as a sensitive probe for tracing intracellular pH changes." RSC Advances 5, no. 21 (2015): 15778–83. http://dx.doi.org/10.1039/c4ra11347k.

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A.AlOmari, Nohad, Adnan O. Omar, and Iklas M. Taher. "Preliminary Cytotoxic Study of Some Novel Furo-2-quinolone Compounds." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 18, Suppl. (2017): 32–38. http://dx.doi.org/10.31351/vol18isssuppl.pp32-38.

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In this research, new series of Furo-2-quinolone [FQ] compounds have been synthesized. These novel [FQ] compounds were prepared from coumarin derivatives (Furocoumarins: psoralen and isopsoralen).Identifications of these FQ compounds were performed by using infrared spectrum (I.R), Ultraviolet spectrum (U.V) and Nuclear Magnetic Resonance spectrum (H1-NMR) besides some physical data. The cytotoxic screening involves ;using HEP-2 cell line which gave differential responses against tested compounds : 4,6 Dimethyl furo[2, 3-g] coumarin (C1), 1-(2`, 4`, Dimethoxy benzylideneimino)-2,6-dimethyl Fur

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