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Dissertations / Theses on the topic 'Coumarin synthesis'

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Published: 4 June 2021
Last updated: 6 February 2022

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1

Lui, Chih-Hung. "Molecular design and synthesis of coumarin fluorescent dyes." Thesis, Heriot-Watt University, 2000. http://hdl.handle.net/10399/572.

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2

Cairns, N. "Total syntheses of naturally occurring linear coumarins." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382619.

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3

Okerio, Jaspher Mosomi. "Synthesis of fluorescent polymers with coumarin backbones by "click" polymerization." Thesis, Nelson Mandela Metropolitan University, 2013. http://hdl.handle.net/10948/d1020132.

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Click chemistry is one of the growing areas of research which is applied in the design and synthesis of a wide range of polymeric architectures. This investigation focuses on the synthesis of fluorescent coumarin based polymers by “click” A-B step growth polymerization process and evaluation of their photophysical properties. Non-fluorescent azide-alkyne functionalized coumarin-based monomers were synthesized in multiple steps from 2,4-dihydroxybenzaldehyde in reasonable yields. Polymers with coumarin backbone were synthesized from azide-alkyne functionalized coumarin monomers via the Cu(I) ca
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4

Trenor, Scott Russell. "Synthesis and Characterization of Tailored Photoactive Macromolecules." Diss., Virginia Tech, 2004. http://hdl.handle.net/10919/27314.

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Coumarin and cinnamate derivatives were positioned as either polymer chain ends or side groups to synthesize photoactive macromolecules and gain the ability to reversibly control molecular weight and crosslink density using UV light. The cinnamates and coumarins were reacted onto the polymers via multiple reaction pathways. Polymers were functionalized with coumarin or cinnamate groups via an esterification reaction between hydroxyl functionalities and an acid chloride derivatized coumarin group. In addition to the esterification reaction, cinnamates were also coupled to polymers via a ring
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5

Musa, Musiliyu Ayodele. "Applications of the Baylis-Hillman reaction in the synthesis of coumarin derivatives." Thesis, Rhodes University, 2003. http://eprints.ru.ac.za/2319/1/MUSA-PhD-TR03-74.pdf.

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The reaction of specially prepared salicylaldehyde benzyl ethers with the activated alkenes, methyl acrylate or acrylonitrile, in the presence of the catalyst, DABCO, has afforded Baylis-Hillman products, which have been subjected to conjugate addition with either piperidine or benzylamine. Hydrogenolysis of these conjugate addition products in the presence of a palladium-on-carbon catalyst has been shown to afford the corresponding 3-substituted coumarins, while treatment of O-benzylated Baylis-Hillman adducts with HCl or HI afforded the corresponding 3-(halomethyl)coumarins directly, in up
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6

Rashamuse, Thompho Jason. "Studies towards the synthesis of novel, coumarin-based HIV-1 protease inhibitors." Thesis, Rhodes University, 2008. http://eprints.ru.ac.za/1332/.

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7

Rose, Nathan Rolf. "Synthesis of novel coumarin derivatives as potential inhibitors of HIV-1 protease." Thesis, Rhodes University, 2007. http://hdl.handle.net/10962/d1007220.

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This research has focused on the development of novel coumann derivatives containing peptide-like side chains as potential HIV-1 protease inhibitors. The reaction of various salicylaldehyde derivatives with tert-butyl acrylate In the presence of 1,4- diazabicyclo[2.2.2]octane (DABCO) has afforded a series of Baylis-Hillman adducts in moderate yield. Cyclisation of the adducts in the presence of HCI afforded the corresponding 3-(chloromethyl)coumarin derivatives, which have been reacted with various amine hydrochlorides in the presence of Proton Sponge® to afford a series of novel 3- (aminometh
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8

Liu, Tsz-chung Alvin, and 廖子衝. "Design and synthesis of luminescent coumarin-containing platinum (II) terpyridine alkynyl complexes and their spectroscopic, photophysicaland binding studies." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47168353.

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9

Liu, Yannan. "Benzo[c]quinolizine, coumarin, and spiroisoxazolinoproline : lead-based heterocycle design and parallel synthesis /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2002. http://uclibs.org/PID/11984.

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10

Shadmehr, Mehrdad, and Mehrdad Shadmehr. "Design and Synthesis of Triazabutadiene-based Fluorogenic Probes for Tyrosine Specific Labeling of Proteins." Diss., The University of Arizona, 2018. http://hdl.handle.net/10150/626757.

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Chemical labeling is an important tool for understanding protein structure and function. Biological research often requires the use of molecular labels that are covalently attached to facilitate detection or purification of the labeled protein and its binding partners. Although the number of probes have been developed for labeling of specific residues of proteins is substantial, there is still a need for new reagents with better reactivity, and selectivity. Moreover, these chemical probes should be able to label the protein of interest under mild biologically relevant conditions. Aryl diazon
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11

Concannon, Shauna. "A study of the isolation, synthesis, structural elucidation and biological properties of coumarin derivatives." Thesis, University of Ulster, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274067.

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12

Row, Eleanor Catherine. "Design, synthesis and evaluation of coumarin and furanocoumarin compounds as inhibitors of CYP3A4 and P-glycoprotein." Thesis, University of Sheffield, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.401162.

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13

Wali, Nwabisa Whitney. "Synthesis of fluorescent polymers with pendant triazole-substituted coumarin side-chains via a combination of click chemistry and raft-mediated polymerization." Thesis, Nelson Mandela Metropolitan University, 2013. http://hdl.handle.net/10948/d1020142.

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This research project focuses on the synthesis of fluorescent polymers with pendant triazole-substituted coumarin side chain units. Copper(I)-catalyzed Huisgen’s 1,3-dipolar cycloaddition of alkynes with azides to form a 1,2,3-triazole ring, a typical example of “click” reaction, has been utilized for the synthesis of a novel vinyl monomer, 2-oxo-3-(4- vinyl-1H-1,2,3-triazol-1-yl)-2H-chromen-7-yl acetate 62. The monomer and its precursors were synthesised and characterized using 1D- and 2D-NMR and FT-IR. Coumarin-containing triazole polymers were synthesised using free radical polymerization.
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14

Chi, Li-Jen. "Synthesis and computer-aided structural investigation of potentially photochromic spirooxazines." Thesis, Heriot-Watt University, 2000. http://hdl.handle.net/10399/564.

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15

Foka, Germaine Boulenoue. "Synthesis and evaluation of novel coumarin-donepezil derivatives as dual acting monoamine oxidase B and cholinesterase in Alzheimer's disease." University of the Western Cape, 2016. http://hdl.handle.net/11394/5549.

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Magister Pharmaceuticae - MPharm<br>Alzheimer's disease is a progressive neurodegenerative disease characterised by low acetylcholine (ACh) levels in the hippocampus and cortex of the brain, causing symptoms like progressive memory loss, decline in language skills and other cognitive impairments to occur. The hallmarks of AD include the presence of extracellular insoluble amyloid beta plaques, intracellular neurofibrillary tangles, and the decrease in ACh concentration. The pathophysiology of AD is not well understood, however, acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and mon
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16

Mzezewa, Sheunopa C. "Synthesis and evaluation of 7-substituted 3-propargylamine coumarin derivatives as multifunctional monoamine oxidase and cholinesterase inhibitors for Alzheimer’s Disease treatme." University of Western Cape, 2020. http://hdl.handle.net/11394/7399.

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>Magister Scientiae - MSc<br>Alzheimer’s Disease (AD) is a neurodegenerative disease which results from the irreversible loss of neurons in the brain. The disease is characterized by progressive cognitive impairment with recurrent short-term memory loss. AD is the leading cause of dementia and 4th leading cause of death in the elderly. Success in the treatment of AD has been limited, with drugs only treating it at a symptomatic level due to its pathology being complex and poorly understood. However, it is known that the cholinesterase and MAO-B enzymes play an important role in the disease thr
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17

Lizzul-Jurse, Antoine. "Développement de nouvelles réactions de click in situ appliquées à la synthése d'inhibiteurs de la β-sécrétase". Thesis, Normandie, 2017. http://www.theses.fr/2017NORMR020.

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La synthèse contrôlée par la cible sous contrôle cinétique (Kinetic Target-Guided Synthesis, KTGS) est une approche relativement peu explorée, alternative à la chimie combinatoire traditionnelle,dans laquelle la protéine cible participe à la synthèse du ou de ses propres ligands. Ainsi, les travaux présentés dans la première partie de cette thèse ont pour principal objectif d'élargir l'éventail des réactions actuellement disponibles en KTGS grâce à la réaction d'aldolisation voire d'amidation, et ce en utilisant la β-sécrétase (BACE-1) comme cible biologique, qui est une enzyme étroitement imp
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18

García, Guzmán Claudia María. "Optical probes for enhanced targeting of cancer." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28902.

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The diagnosis of cancer in early stages is an unmet clinical need, especially in view that current treatments for cancer cannot address metastatic disease. Cancer aberration processes are associated to an increase in the production of reactive oxygen species (ROS). Chemical probes that can specifically detect these species are potentially useful as medical diagnostics and research tools for cancer imaging. One of the aims of my thesis was the design and synthesis of the activatable fluorescent probes based on small molecule fluorophores modified with chemically reactive moieties. The activatio
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19

Rodriguez, Dominguez Juan Carlos Kirsch Gilbert Prieto Sylvia. "Nouvelles synthèses de dérivés hetérocycliques pour applications biologiques (Céphalosporines, Coumarines et Indoles) = New synthesis of heterocyclic derivatives for biological applications (Cephalosporins, Coumarins and Indoles) /." [S.l.] : [s.n.], 2006. ftp://ftp.scd.univ-metz.fr/pub/Theses/2006/Rodriguez%20Dominguez.Juan%20Carlos.SMZ0618.pdf.

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20

Bruyat, Pierrick. "Synthèse de molécules peptidomimétiques pour inhiber la formation de biofilms bactériens." Thesis, Normandie, 2018. http://www.theses.fr/2018NORMR136.

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La plupart des bactéries vivent en communautés organisées, appelées biofilms, augmentant leur résistance aux traitements antibiotiques. Ainsi, la formation de biofilms sur les organes et matériels médicaux est considérée comme la cause de la majorité des infections bactériennes. Il est alors important de trouver des traitements pour empêcher ou perturber la formation de ces biofilms. Il a été proposé que les porines de P. Stuartii, Omp-Pst1 et Omp-Pst2, peuvent s’auto-assembler via un steric-zipper, étape responsable du développement initial du biofilm. Ainsi, notre objectif est de synthétiser
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21

Debieu, Sylvain. "Synthèse in situ de fluorophores organiques : formation de liaisons covalentes par déclenchement enzymatique et applications en biodétection." Thesis, Bourgogne Franche-Comté, 2017. http://www.theses.fr/2017UBFCK051/document.

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L'imagerie de fluorescence s'est particulièrement développée au fil de ces dernières décennies notamment pour l'exploration des systèmes biologiques. De nombreux développements portant à la fois sur les instruments d'analyse et les agents de contraste (sondes) ont été entrepris pour améliorer cette technique de bioanalyse. Mes travaux de thèse avaient pour but d'explorer diverses plateformes moléculaires pro-fluorescentes pouvant générer, sous l'effet d'un stimulus biologique / chimique, un fluorophore organique. Cette approche de synthèse chimique in-situ met en jeu des réactions domino carac
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22

Updegraff, James Benjamin III. "Synthesis and Characterization of Hexanuclear Rhenium Chalcogenide Clusters Containing Potential Two-Photon Absorbing Ligands and the Synthesis and Characterization of Gold-Substituted Coumarins." Cleveland, Ohio : Case Western Reserve University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1257472176.

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Thesis(Ph.D.)--Case Western Reserve University, 2010<br>Title from PDF (viewed on 2009-12-30) Department of Chemistry Includes abstract Includes bibliographical references and appendices Available online via the OhioLINK ETD Center
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23

Rodriguez, Dominguez Juan Carlos. "Nouvelles synthèses de dérivés hetérocycliques pour applications biologiques : (Céphalosporines, Coumarines et Indoles) = New synthesis of heterocyclic derivatives for biological applications (Cephalosporins, Coumarins and Indoles)." Metz, 2006. http://docnum.univ-lorraine.fr/public/UPV-M/Theses/2006/Rodriguez_Dominguez_Juan_Carlos_SMZ0618.pdf.

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Les céphalosporines de synthèse, les dérivés de coumarines et indoles sont des composés très intéressant dans le domaine de la biochimie. Les premières sont utilisées habituellement dans le système de santé mondiale contre les infections bactériennes ; les secondes et les dernières, sont présentes dans les sciences de la nature et de la vie avec des larges gammes d'activités et des usages biologiques. Due à leurs importantes applications, il apparait nécessaire d'avoir des méthodes efficaces pour synthétiser ces produits. Des temps de réactions plus courts, de bons rendements, un travail fait
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24

Zaitceva, Olesia. "Development of new synthetic tools for the preparation of coumarins and thiocoumarins." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAF014.

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Pour la première fois la coumarine a été isolée à l’état naturel en 1820. Depuis, les scientifiques ont extraits plus d’une mille de combinaisons de coumarines et développé plusieurs voies de leur synthèses. Les coumarines sont largement utilisées en pharmacie, médecine, chimie optique et biochimie. Thiocoumarine quant à elle intervient dans les domaines similaires à celui de coumarine. Grâce à ce vaste champ d’applications de coumarines et un grand potentiel de thiocoumarines, nous avons décidé de mettre au point de nouvelles méthodes pour synthétiser ces composants. Le but principal de notre
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25

Verghese, Jenson. "Investigations of Novel Mechanisms of Action for Anti-Bacterial and Anti-Cancer Agent Development." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/611.

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The development of drugs and therapeutic agents for combating infections and human malignancies continues to be a forefront area in both academic and industrial research. This is driven by the rapid emergence of multi-drug resistant bacterial strains and accumulating mutations in cancer targets that is quickly rendering our current arsenal of drugs ineffective for these therapies. Unless new drugs with novel mechanisms of action are identified and developed at a faster pace, we face a losing battle in managing these diseases. The first part of this work concerns with the natural product Simocy
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26

Lujan, Barroso Cristina. "Atom transfer radical cyclisation reactions in organic synthesis." Thesis, University of Manchester, 2010. https://www.research.manchester.ac.uk/portal/en/theses/atom-transfer-radical-cyclisation-reactions-in-organic-synthesis(5762bcb7-0c05-4933-b785-1edd68ecb00a).html.

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A new method for the synthesis of naphthalenes has been recently discovered. The Atom Transfer Radical Cyclisation (ATRC) of diverse 2-allylphenyl2',2',2'-trichloroacetates in the presence of a Cu complex afford schloronaphthalenes in good yields using either microwave or thermolytic methods of activation. A mechanism for the benzannulation reaction is proposed and experiments presented in order to validate this hypothesis. The use of 1,3-bis(2,6-diisopropylphenyl)imidazolium copper(I) chloride [(IPr)CuCl)] along with other metal carbenes is compared to the already reported CuCl/ligand system.
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27

Ramaite, Ipfani David Isaiah. "Synthetic and physical organic studies of chromone derivatives." Thesis, Rhodes University, 1997. http://hdl.handle.net/10962/d1005045.

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A range of chromone-2-carboxylic acids has been prepared by condensing suitably substituted 2-hydroxyacetophenones with diethyl oxalate. pK₂ Studies of these acids revealed that 6- or 7-methoxy substituents decreased acidity while the 6-nitro group enhanced acidity; the strongest acid was the 3-chloro derivative, the increase in acidity being attributed to steric inhibition of acid-weakening delocalisation between the carboxyl group and the chromone system. Various chromone-2-carboxamides, derived from acid chloride precursors, were converted to polysubstituted acrylamides by nucleophilic ring
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28

Alves, Anna Carolina Schneider. "Planejamento, síntese e avaliação in vitro de híbridos 1,2,3-triazol-4-clorometilcumarinas com potencial atividade antioxidante." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/164785.

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Cumarinas são metabólitos secundários de plantas encontrados majoritariamente nas espécies das famílias Asteraceae, Rutaceae e Umbeliferae. Quimicamente, são compostos fenólicos, formados pela fusão de um benzeno e de um anel α-pirona, chamados de benzopironas. Elas apresentam diversas propriedades farmacológicas, associadas com baixa toxicidade. Nosso grupo de pesquisa sintetiza cumarinas pela reação de Pechmann, que ocorre através da condensação de um fenol com um β-cetoéster, na presença de um ácido de Bronsted ou Lewis. Um dos trabalhos mais recentes foi a síntese de 6-metil-4-clorometilcu
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29

Robinson, Ross Stuart. "Baylis-Hillman derived benzopyrans and related systems : a synthetic and mechanistic study." Thesis, Rhodes University, 1998. http://hdl.handle.net/10962/d1007193.

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The Baylis-Hillman reaction between substituted salicylaldehydes and various acrylate species has been shown to afford complex reaction mixtures, careful chromatography of which has led to the isolation of an extensive range of novel compounds. One- and two-dimensional NMR spectroscopic, mass spectrometric and X-ray crystallographic analysis of these compounds have permitted identification of no less than eight general classes of chromene and coumarin derivatives. The formation of the various product types is attributed to cascades of successive reactions stemming, in each case, from a Baylis-
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30

Zwergel, Clemens. "Synthesis and biological evaluation of various heterocyclic compounds : Aurones from Coumarins and Chromones, Quinolines and Pyrimidines as DNMTi, Coumarins as potential NF-kB inhibitors." Thesis, Université de Lorraine, 2013. http://www.theses.fr/2013LORR0276/document.

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Aujourd'hui, le cancer est devenu un problème majeur de santé publique avec 12,7 millions de nouveaux cas de cancer et 7,6 millions de décès enregistrés en 2008. Même si le nombre des personnes qui guérissent augmente, les décès sont toujours importants. Les raisons, malgré un diagnostic précoce et correct, sont l'absence de traitements efficaces et l'émergence des résistances à la thérapie anticancéreuse. C'est pourquoi les chercheurs s'intéressent aux nouvelles approches pour développer des traitements puissants et sélectifs pour vaincre le cancer. Dans notre première approche, nous avons dé
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31

Torres, Fernando Cidade. "Isolamento de cumarinas de espécies de Pterocaulon (Asteraceae) e síntese de 4-metilcumarinas." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2014. http://hdl.handle.net/10183/159514.

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As cumarinas são estruturas interessantes aos olhos da química medicinal, apresentando diversas atividades biológicas sobre os mais variados alvos. Neste trabalho, em um primeiro momento, realizamos a extração com CO2 em meio supercrítico das cumarinas de Pterocaulon balansae, planta nativa do Rio Grande do Sul que apresenta em sua composição grandes quantidades destes compostos. A extração com CO2 supercrítico apresentou rendimentos satisfatórios em massa de sete cumarinas previamente descritas para estas espécies. Dentre estes se destacam os compostos majoritários 7-(2,3-epoxi-3-metil-3-buti
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32

Kasumbwe, Kabange. "Biological activities of synthetic coumarin derivatives." Thesis, 2016. http://hdl.handle.net/10321/1733.

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Submitted in partial fulfillment for the Degree of Master of Applied Sciences in Biotechnology, Durban University of Technology, Durban, South Africa, 2016.<br>Coumarins are naturally occurring α-benzopyrone derivatives known for their pharmacological properties such as anticoagulant, antimicrobial, anticancer, antioxidant, anti-inflammatory and antiviral properties. The pharmacological, biochemical, and curative applications of coumarins depend on the substitution around the coumarin core structure. In the present study, seven halogenated coumarins CMRN1 - CMRN7 were synthesized and evaluated
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33

蘇長孝. "Synthesis and Biological Evaluation of Coumarin Derivatives." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/86203434887042864258.

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碩士<br>國防醫學院<br>藥學研究所<br>92<br>It has been reported that coumarin derivatives showed many medical properties, such as anticoagulant, allergic and antimicrobial. Recently, coumarin derivatives has further been applied to the treatment of the AIDS. NSC158393, a coumarin tetramer, has shown potent inhibitory activity (IC50 = 1.5 µM) against HIV-1 integrase. Based on the structural features of the lead compound, we start to design and synthesize 42 compounds with similar structural features. Synthesis to the target compounds was performed starting from mono- or di-hydroxybenzoic acid with 4-hydroxy
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Corkery, Timothy Christopher. "Polymers with pendant coumarins : synthesis and characterization of polystyrenes and polymethacrylates with pendant coumarin moieties." 2006. http://hdl.handle.net/1993/20287.

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Zheng, Dong-Yang, and 鄭東陽. "Synthesis of Coumarin Derivatives as Potential UV Absorbers." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/01576818039766286330.

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碩士<br>中華科技大學<br>健康科技研究所<br>101<br>In the past decades, the amounts of UV radiation reaching to the surface of the earth has been increasing due to the collapsed ozone layer. When people are overexposed to the circumstances of the UV sunlight, it may cause a number of skin damage such as spots, wrinkle, hyperpigmentation and even skin cancer. Chemical sunscreens, absorbing and converting high-intensity UV rays into longer lower-energy unharmful wavelengths have proven to be quite effective for the prevention of the erythema reaction of human skin. However, in order to get the high effectiveness
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Chang, Chao-Che, and 張肇哲. "Synthesis of Coumarin Derivatives for Metal Ions Sensing." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/19545765182091694512.

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碩士<br>國立臺灣大學<br>化學研究所<br>93<br>The main objective of this thesis is to design and synthesize fluorescent chemosensors for detection of metal ions. Coumarin fluorophores were chosen to serve as signal transducer. Various recognition units were coupled with the signal transducer units in order to investigate how these recognition units influence metal ion selectivity. Accordingly, fluorescent chemosensor 1-9 were prepared. Both fluorosensor 1 and 2 consist of polyethylene glycol as recognition unit. The preorganized recognition unit, diaza-18-crown-6, was employed in the case of fluorosensors 3
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Lin, Yi-De, and 林奕德. "The Synthesis and Application of Coumarin Fluorescent Dyes." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/888grh.

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碩士<br>國立臺北科技大學<br>有機高分子研究所<br>99<br>With the improvement of quality of life, people pay attention to functional clothing gradually, therefore constantly the demand of water repellent finishingconstomtly increases. It makes the clothing of going out which needs to consider about water repellent, and it become a high value-added processing project. However, fabric process with water repellent finishing, not only hand feeling but dyeing fastness decline, besides, dyeing wastewater with residual water repellent agents result in environmental pollution, therefore it requiring new manufacture proced
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CHANG, FANG-CHI, and 張芳齊. "Synthesis of New Coumarin Derivatives for Metal Ion." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/36334925674936309779.

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碩士<br>明志科技大學<br>化學工程系碩士班<br>105<br>In this study, coumarin derivative (C6H-Imine) had been successfully synthesized by Vilsmeier reaction, Knoevenagel condensation, hydrolysis and condensation of amine and aldehydes. The structures of these coumarin dyes (C6H-Ethyl ester, C6H, C6H-Aldehyde and C6H-Imine) were characterized by 1H-NMR, FTIR and MASS spectra. The photophysical properties of the C6H-Imine were studied by absorption and steady-state fluorescence spectroscopy in acetonitrile, and compared with the C6H-Imine(methyl). The photophysical results showed that the C6H-Imine without a methy
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Chih-Min, Mao, and 毛志民. "SYNTHESIS AND BIOLOGICAL EVALUATION OF COUMARIN ISOSTERIC ANALOGUES." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/72439730919756040627.

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碩士<br>國防醫學院<br>藥學研究所<br>87<br>Recently, coumarin analogues have been identified as effective inhibitors of HIV-1 integrase. Based on the structural feature of lead compound (NSC 158393) of HIV-1 integrase inhibitors, a series of bioisosteric analogues of coumarin has been designed and synthesized. We have prepared 20 intermediates and 36 final products. Twenty three compounds(T01-T23) have been evaluated for the anticoagulant effect. Compounds T01, T10, T11 were shown moderately inhibitory activity against platelet aggregation induced by collagen. Structure-activity analysis indicat
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40

Lin, Yu Chung, and 林佑忠. "Synthesis of Coumarin Derivatives and Their Photophysical Property Studies." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/97357796346039188852.

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碩士<br>國立臺灣大學<br>化學研究所<br>90<br>Most of coumarin derivatives, like coumarin 1 and coumarin 6, have highly fluorescent quantum efficiency in solution, but at solid phase their fluorescent quantum efficiency rapidly decreases. The main reason of causing the decrease of quantum efficiency can be attributed to the phenomenon of aggregation. The objectives of this research is to design and synthesize coumarin derivatives with high fluorescent yield not only in solution also at solid state. The diphenyl amino groups are introduced in the place of the diethyl amino group at 7-position of coumarin. Th
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41

PENG, YU-TING, and 彭郁婷. "Multicomponent Synthesis of Pyrrolizidine and Azepine/Coumarin-Fused Derivatives." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/77509669272920214476.

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碩士<br>東海大學<br>化學系<br>105<br>In this thesis, we report the design, synthesis, and characterization of pyrrolizidine and azepine/coumarin-fused compounds via multicomponent reactions and subsequent evaluation of their potential antibacterial activities. In the first part, microwave-assisted three-component reactions of L-proline, benzaldehyde and 1,3-indandione obtained the pyrrolizidine derivatives. In the second part, the azepine/coumarin-fused seven-membered heterocyclic derivatives were prepared by condensation of 3-amino-4-hydroxycoumarin with acetophenone in a pseudo three-component reacti
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42

Chun-Ming, Wu, and 吳峻鳴. "Synthesis of Coumarin-based Triazoline-Calix[4]arenes and." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/81608496669750319050.

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碩士<br>國立交通大學<br>應用化學系所<br>94<br>The previous research of M.-T. Tsai in our laboratory showed that compounds 47 ~ 50 which contain mono- or bis-3-triazoline-7-N,N- diethyl amino coumarin substituted calix[4]arenas were very selective towared Cu2+ and Hg2+ ions. In this thesis, we carried out UV-Vis and fluorescence titrations analys of each complex and the binding constant of each complex was obtained by Stern-Volmer equation. The binding constants (Ka) are about 104 ~ 105 M-1 for 1 : 1 binding mode. Besides, NMR titration of each complex indicated that coumarin carbonyl and triazoline on 47 ~
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43

Lin, Li, and 林立. "Synthesis and Biological Evaluation of Coumarin-3-Carboxamide Derivatives via Ring-Opening Reaction of Coumarin-3-Activated Aziridines." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/51699927764062756603.

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碩士<br>臺北醫學大學<br>藥學系<br>94<br>Coumarin is important structure of organic chemistry and belongs to the benzopyrones. Coumarins are widely distributed in plants and have a variety of bioactivities including anticoagulation, estrogenic, dermal photosensitizing, antimicrobial, antioxidation, vasodilation, antithelmintic, sedative and hypnotic, analgesic and hypothermic activities. Aziridine is a class of compound important both in chemical synthesis and in chemotherapy of cancer. Ring opening of 2-methyl-N-acylaziridine by various nucleophiles has been reported. Nucleophilic attack at the
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44

Chou, Wei-Cheng, and 周韋丞. "Synthesis of New Adenosine–Coumarin Phosphate Derivatives Against Flaviviridae Viruses." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/h56du5.

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45

Li, Xhian-Bin, and 李賢斌. "Synthesis of Coumarin Derivatives and Discussions of Their Fluorescent Properties." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/82sv69.

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碩士<br>國立臺北科技大學<br>有機高分子研究所<br>93<br>In general, derivatives of coumarin have superior fluorescent properties and good quantum yield, thus they were be taken as luminescent materials on luminescent layer in organic light emitting diodes which emit blue and green light. Three series of coumarin dyes were synthesized from raw materials. Among them, dyes of series Ⅱ are new compounds. The relationship between their optical properties with the structure of dyes were discussed. The fluorescence wavelengths of Dye ⅠC、ⅡC and ⅢC are in neutral red light range. PLED and OLED devices were prepared by Dy
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46

Huang, Chun-Ping, and 黃俊評. "Synthesis and Application of a Novel Coumarin-based Sensitized Dye." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/78346703831112871649.

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碩士<br>明志科技大學<br>化學工程研究所<br>102<br>In this study, we have successfully synthesized a novel coumarin derivative dye (SQ-214) by Vilsmeier reaction, Knoevenagel condensation, nucleophilic addition and hydration reaction. The structures of these coumarin dyes (T-C6H, FT-C6H and SQ-214) were identified by using 1H-NMR, MASS and FT-IR spectroscopy. The photophysical properties of these dyes were studied by absorption and fluorescence spectroscopy in dichloromethane. The final compound SQ-214 dye and commercial C343 dye were applied in dye-sensitized solar cell (DSSC). The C343-based DSSC exhibited a
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47

Li, Kuan-Ting, and 黎冠廷. "Synthesis of Coumarin-Based Heterocyclic Derivatives as Potential Multifunctional Molecular Switches." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/20998178428893972893.

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碩士<br>東海大學<br>化學系<br>100<br>In part one, a number of coumarin/phenanthridine-fused heterocycles were efficiently synthesized using base-mediated annulation of coumarin and N-alkylquinolinium iodide as a key step. The prepared compounds and their corresponding ring open forms exhibit lockable switching properties, that is, they are interchangeable via pH control and can also be further converted to their “pH-inert” forms by chemical oxidation and reduction. In part two, two new pyranocoumarins were synthesized and characterized via one-pot, microwave-assisted pseudo multicomponent condensation
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48

Li, You-chang, and 黎祐誠. "Synthesis and Metal Recognition Behavior Studies of Coumarin Substituted Ferrocene Derivatives." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/67439628190648748143.

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碩士<br>朝陽科技大學<br>應用化學系碩士班<br>102<br>This study use azine group to linked coumarin group and ferrocene unit, and we are also makes different modified on the ferrocene unit. Both compound S and S1were characterized by NMR, IR and Mass spectra to confirm the structure. Compound S shows obviously recognize behavior with mercury ions. In the UV-vis spectra, when Hg ions added in the solution of S, the absorption band will lead to a red shift, which is speculated the result of coordination of Hg ion with azine group and coumarin unit. In Job&apos;&apos;s plot experiments, the binding mode of compound
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49

Huang, Chien Huang, and 黃健煌. "Synthesis and Physical Property Studies of Amorphous Biphenyl-Linked Coumarin Dimers." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/86671972941340399886.

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碩士<br>國立臺灣大學<br>化學研究所<br>89<br>The objectives of this thesis are to prepare a series of amorphous biphenyl-linked coumarin dimmers (2, 3, 4, 5) to circumvent the phenomenon of aggregation at solid state in the application of organic light emitting diode (OLED). In the molecules designs, we introduced either two methyl groups or phenyl groups on 2, 2'-position of the biphenyl moiety as well as four methyl group substituted on 2, 2', 6, 6'-position of the biphenyl. The steric effects of the substitutents should augment the non-planarity of the molecules and decrease the possibility of aggregatio
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50

Tsai, Cheng-Jang, and 蔡成章. "The Synthesis and Optoelectronic Properties of Electroluminescent Polymers Containing Coumarin Side Chains." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/27112888737013570938.

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博士<br>國立成功大學<br>化學工程學系碩博士班<br>95<br>In this investigation, we synthesized new polymeric electroluminescent (EL) materials, which can be divided into three parts: (1) poly(p-phenyleneviny1ene) (PPV) derivatives P1 and P2, containing hexyloxy side groups and 7-oxy-4-methylcoumarin (OMC) groups via hexyloxy spacer, respectively; (2) four copolyethers (P3-P6) consisting of two isolated emitting chromophores [2,5-dihexyloxy-1,4-distyrylbenzene (HODSB) and 2,5-dihexyloxy-1,4- di(4-methylenestyryl)benzene (HOMDSB) for P3 and P4, 2,5-dihexyl-1,4-distyrylbenzene (HDSB) and HOMDSB for P5 and P6 in the b
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