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Journal articles on the topic 'COX1'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Khalimonchuk, Oleh, Megan Bestwick, Brigitte Meunier, Talina C. Watts, and Dennis R. Winge. "Formation of the Redox Cofactor Centers during Cox1 Maturation in Yeast Cytochrome Oxidase." Molecular and Cellular Biology 30, no. 4 (2009): 1004–17. http://dx.doi.org/10.1128/mcb.00640-09.

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ABSTRACT The biogenesis of cytochrome c oxidase initiates with synthesis and maturation of the mitochondrion-encoded Cox1 subunit prior to the addition of other subunits. Cox1 contains redox cofactors, including the low-spin heme a center and the heterobimetallic heme a 3:CuB center. We sought to identify the step in the maturation of Cox1 in which the redox cofactor centers are assembled. Newly synthesized Cox1 is incorporated within one early assembly intermediate containing Mss51 in Saccharomyces cerevisiae. Subsequent Cox1 maturation involves the progression to downstream assembly intermed

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Mick, David U., Milena Vukotic, Heike Piechura, et al. "Coa3 and Cox14 are essential for negative feedback regulation of COX1 translation in mitochondria." Journal of Cell Biology 191, no. 1 (2010): 141–54. http://dx.doi.org/10.1083/jcb.201007026.

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Regulation of eukaryotic cytochrome oxidase assembly occurs at the level of Cox1 translation, its central mitochondria-encoded subunit. Translation of COX1 messenger RNA is coupled to complex assembly in a negative feedback loop: the translational activator Mss51 is thought to be sequestered to assembly intermediates, rendering it incompetent to promote translation. In this study, we identify Coa3 (cytochrome oxidase assembly factor 3; Yjl062w-A), a novel regulator of mitochondrial COX1 translation and cytochrome oxidase assembly. We show that Coa3 and Cox14 form assembly intermediates with ne

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3

Mohammad Fathul Qorib. "Dinamika Ekspresi Cox1 dan Cox2 Sebagai Landasan Tatalaksana Nyeri dan Inflamasi." Unram Medical Journal 11, no. 4 (2022): 1233–39. http://dx.doi.org/10.29303/jku.v11i4.868.

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Siklooksigenase (COX) merupakan enzim yang sangat penting dalam menjaga homeostasis organ tubuh manusia. Enzim ini berperan pada kondisi fisiologis dan patologis khususnya saat terjadi inflamasi. Enzim ini memiliki 3 isoform yaitu Cox1, Cox2, dan Cox3. Isoform yang banyak diteliti dan terbukti sangat berperan dalam tubuh manusia adalah Cox1 dan Cox2, sedangkan Cox3 masih banyak perbedaan pendapat. Ekpresi Cox1 dan Cox2 dapat ditemukan pada berbagai organ dalam tubuh manusia, akan tetapi dalam naskah ini akan dibatasi pembahasannya pada lambung, ginjal, saraf, kardiovaskular, dan platelet. Hal

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Pierrel, Fabien, Oleh Khalimonchuk, Paul A. Cobine, Megan Bestwick, and Dennis R. Winge. "Coa2 Is an Assembly Factor for Yeast Cytochrome c Oxidase Biogenesis That Facilitates the Maturation of Cox1." Molecular and Cellular Biology 28, no. 16 (2008): 4927–39. http://dx.doi.org/10.1128/mcb.00057-08.

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ABSTRACT The assembly of cytochrome c oxidase (CcO) in yeast mitochondria is dependent on a new assembly factor designated Coa2. Coa2 was identified from its ability to suppress the respiratory deficiency of coa1Δ and shy1Δ cells. Coa1 and Shy1 function at an early step in maturation of the Cox1 subunit of CcO. Coa2 functions downstream of the Mss51-Coa1 step in Cox1 maturation and likely concurrent with the Shy1-related heme a 3 insertion into Cox1. Coa2 interacts with Shy1. Cells lacking Coa2 show a rapid degradation of newly synthesized Cox1. Rapid Cox1 proteolysis also occurs in shy1Δ cell

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5

Zambrano, Andrea, Flavia Fontanesi, Asun Solans, et al. "Aberrant Translation of CytochromecOxidase Subunit 1 mRNA Species in the Absence of Mss51p in the YeastSaccharomyces cerevisiae." Molecular Biology of the Cell 18, no. 2 (2007): 523–35. http://dx.doi.org/10.1091/mbc.e06-09-0803.

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Expression of yeast mitochondrial genes depends on specific translational activators acting on the 5′-untranslated region of their target mRNAs. Mss51p is a translational factor for cytochrome c oxidase subunit 1 (COX1) mRNA and a key player in down-regulating Cox1p expression when subunits with which it normally interacts are not available. Mss51p probably acts on the 5′-untranslated region of COX1 mRNA to initiate translation and on the coding sequence itself to facilitate elongation. Mss51p binds newly synthesized Cox1p, an interaction that could be necessary for translation. To gain insigh

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Roloff, Gabrielle A., and Michael F. Henry. "Mam33 promotes cytochromecoxidase subunit I translation inSaccharomyces cerevisiaemitochondria." Molecular Biology of the Cell 26, no. 16 (2015): 2885–94. http://dx.doi.org/10.1091/mbc.e15-04-0222.

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Three mitochondrial DNA–encoded proteins, Cox1, Cox2, and Cox3, comprise the core of the cytochrome c oxidase complex. Gene-specific translational activators ensure that these respiratory chain subunits are synthesized at the correct location and in stoichiometric ratios to prevent unassembled protein products from generating free oxygen radicals. In the yeast Saccharomyces cerevisiae, the nuclear-encoded proteins Mss51 and Pet309 specifically activate mitochondrial translation of the largest subunit, Cox1. Here we report that Mam33 is a third COX1 translational activator in yeast mitochondria

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7

Bestwick, Megan, Oleh Khalimonchuk, Fabien Pierrel, and Dennis R. Winge. "The Role of Coa2 in Hemylation of Yeast Cox1 Revealed by Its Genetic Interaction with Cox10." Molecular and Cellular Biology 30, no. 1 (2009): 172–85. http://dx.doi.org/10.1128/mcb.00869-09.

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ABSTRACT Saccharomyces cerevisiae cells lacking the cytochrome c oxidase (CcO) assembly factor Coa2 are impaired in Cox1 maturation and exhibit a rapid degradation of newly synthesized Cox1. The respiratory deficiency of coa2Δ cells is suppressed either by the presence of a mutant allele of the Cox10 farnesyl transferase involved in heme a biosynthesis or through impaired proteolysis by the disruption of the mitochondrial Oma1 protease. Cox10 with an N196K substitution functions as a robust gain-of-function suppressor of the respiratory deficiency of coa2Δ cells but lacks suppressor activity f

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8

Mitchell, Jane A., Fisnik Shala, Youssef Elghazouli, et al. "Cell-Specific Gene Deletion Reveals the Antithrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin Paradox." Circulation Research 125, no. 9 (2019): 847–54. http://dx.doi.org/10.1161/circresaha.119.314927.

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Rationale: Endothelial cells (ECs) and platelets, which respectively produce antithrombotic prostacyclin and prothrombotic thromboxane A 2 , both express COX1 (cyclooxygenase1). Consequently, there has been no way to delineate any antithrombotic role for COX1-derived prostacyclin from the prothrombotic effects of platelet COX1. By contrast, an antithrombotic role for COX2, which is absent in platelets, is straightforward to demonstrate. This has resulted in an incomplete understanding of the relative importance of COX1 versus COX2 in prostacyclin production and antithrombotic protection in viv

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9

Perez-Martinez, Xochitl, Christine A. Butler, Miguel Shingu-Vazquez, and Thomas D. Fox. "Dual Functions of Mss51 Couple Synthesis of Cox1 to Assembly of Cytochrome c Oxidase in Saccharomyces cerevisiae Mitochondria." Molecular Biology of the Cell 20, no. 20 (2009): 4371–80. http://dx.doi.org/10.1091/mbc.e09-06-0522.

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Functional interactions of the translational activator Mss51 with both the mitochondrially encoded COX1 mRNA 5′-untranslated region and with newly synthesized unassembled Cox1 protein suggest that it has a key role in coupling Cox1 synthesis with assembly of cytochrome c oxidase. Mss51 is present at levels that are near rate limiting for expression of a reporter gene inserted at COX1 in mitochondrial DNA, and a substantial fraction of Mss51 is associated with Cox1 protein in assembly intermediates. Thus, sequestration of Mss51 in assembly intermediates could limit Cox1 synthesis in wild type,

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Vanišová, M., D. Burská, J. Křížová, et al. "Stable COX17 Downregulation Leads to Alterations in Mitochondrial Ultrastructure, Decreased Copper Content and Impaired Cytochrome c Oxidase Biogenesis in HEK293 Cells." Folia Biologica 65, no. 4 (2019): 181–87. http://dx.doi.org/10.14712/fb2019065040181.

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Cox17 is an assembly factor that participates in early cytochrome c oxidase (COX, CcO) assembly stages. Cox17 shuttles copper ions from the cytosol to the mitochondria and, together with Sco1 and Sco2, provides copper ions to the Cox1 and Cox2 mitochondrially encoded subunits. In Saccharomyces cerevisiae, Cox17 also modulates mitochondrial membrane architecture due to the interaction of Cox17 with proteins of the MICOS complex (mitochondrial contact site and cristae organizing system). There is currently no data regarding the impact of long-term Cox17 deficiency in human cells. Here, we presen

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Ricketts, Anthony P., Kristin M. Lundy, and Scott B. Seibel. "Evaluation of selective inhibition of canine cyclooxygenase 1 and 2 by carprofen and other nonsteroidal anti-inflammatory drugs." American Journal of Veterinary Research 59, no. 11 (1998): 1441. http://dx.doi.org/10.2460/ajvr.1998.59.11.1441.

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Abstract Objective To evaluate the activity of carprofen and other nonsteroidal anti-inflammatory drugs (NSAID) against isozymes of canine cyclooxygenases (COX1 and COX2). Procedure Constitutive COX1 was obtained from washed canine platelets, and COX2 was obtained from a canine macrophage-like cell line that was induced with endotoxin. Activity of carprofen and other NSAID against COX1 and COX2 was compared. Dose-response curves were plotted, and calculations were performed to identify concentrations that caused 50% inhibition (IC50[μM]) for each isozyme. Ratio of the COX1-to-COX2 IC50 was use

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12

Guan, Y., M. Chang, W. Cho, et al. "Cloning, expression, and regulation of rabbit cyclooxygenase-2 in renal medullary interstitial cells." American Journal of Physiology-Renal Physiology 273, no. 1 (1997): F18—F26. http://dx.doi.org/10.1152/ajprenal.1997.273.1.f18.

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Prostaglandin synthesis requires cyclooxygenase-1 (COX1) or -2 (COX2), which mediate the conversion of arachidonate to prostaglandin H2. COX1 is the predominant constitutive isoform, whereas COX2 expression is typically low. In the present studies we cloned rabbit COX2 and determined its distribution in unstimulated tissues. Screening rabbit eye and uterine libraries yielded two cDNAs containing identical inserts with a 1,812-nucleotide open-reading frame. This encoded a 604-amino acid polypeptide, 90% identical to human, rat, and mouse COX2. Expression of the rabbit COX2 in HEK-293 cells enha

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Valencik, M. L., and J. E. McEwen. "Genetic evidence that different functional domains of the PET54 gene product facilitate expression of the mitochondrial genes COX1 and COX3 in Saccharomyces cerevisiae." Molecular and Cellular Biology 11, no. 5 (1991): 2399–405. http://dx.doi.org/10.1128/mcb.11.5.2399-2405.1991.

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Expression of the yeast mitochondrial genes COX1 and COX3, which encode subunits I and III of cytochrome oxidase, respectively, is controlled by a common nuclear-encoded trans-acting factor. This protein, encoded by the PET54 gene, controls expression of COX1 at the level of RNA splicing and COX3 at the level of mRNA translation. While the steps of COX1 and COX3 gene expression affected by the PET54 gene product are different, it is possible that the PET54 protein is monofunctional and affects expression of each gene by a single mechanism, such as modulation of RNA secondary structure. The goa

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Valencik, M. L., and J. E. McEwen. "Genetic evidence that different functional domains of the PET54 gene product facilitate expression of the mitochondrial genes COX1 and COX3 in Saccharomyces cerevisiae." Molecular and Cellular Biology 11, no. 5 (1991): 2399–405. http://dx.doi.org/10.1128/mcb.11.5.2399.

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Expression of the yeast mitochondrial genes COX1 and COX3, which encode subunits I and III of cytochrome oxidase, respectively, is controlled by a common nuclear-encoded trans-acting factor. This protein, encoded by the PET54 gene, controls expression of COX1 at the level of RNA splicing and COX3 at the level of mRNA translation. While the steps of COX1 and COX3 gene expression affected by the PET54 gene product are different, it is possible that the PET54 protein is monofunctional and affects expression of each gene by a single mechanism, such as modulation of RNA secondary structure. The goa

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15

Hartley, Andrew M., Brigitte Meunier, Nikos Pinotsis, and Amandine Maréchal. "Rcf2 revealed in cryo-EM structures of hypoxic isoforms of mature mitochondrial III-IV supercomplexes." Proceedings of the National Academy of Sciences 117, no. 17 (2020): 9329–37. http://dx.doi.org/10.1073/pnas.1920612117.

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The organization of the mitochondrial electron transport chain proteins into supercomplexes (SCs) is now undisputed; however, their assembly process, or the role of differential expression isoforms, remain to be determined. In Saccharomyces cerevisiae, cytochrome c oxidase (CIV) forms SCs of varying stoichiometry with cytochrome bc1 (CIII). Recent studies have revealed, in normoxic growth conditions, an interface made exclusively by Cox5A, the only yeast respiratory protein that exists as one of two isoforms depending on oxygen levels. Here we present the cryo-EM structures of the III2-IV1 and

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Knoll, Aleš, Lucie Langová, Antonín Přidal, and Tomáš Urban. "Haplotype Diversity in mtDNA of Honeybee in the Czech Republic Confirms Complete Replacement of Autochthonous Population with the C Lineage." Insects 15, no. 7 (2024): 495. http://dx.doi.org/10.3390/insects15070495.

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The study aimed to analyze the genetic diversity in the Czech population of Apis mellifera using mitochondrial DNA markers, tRNAleu-cox2 intergenic region and cox1 gene. A total of 308 samples of bees were collected from the entire Czech Republic (from colonies and flowers in 13 different regions). Following sequencing, several polymorphisms and haplotypes were identified. Analysis of tRNAleu-cox2 sequences revealed three DraI haplotypes (C, A1, and A4). The tRNAleu-cox2 region yielded 10 C lineage haplotypes, one of which is a newly described variant. Three A lineage haplotypes were identifie

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YAZGAN, Burak, and Gülsün MEMİ. "The Effect of Adropin and Spexin Peptides on Cardiac COX and LOX Gene Expressions in Chronic Renal Failure Model." Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi 11, no. 3 (2022): 1013–23. http://dx.doi.org/10.37989/gumussagbil.1097666.

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Bu çalışmada adropin ve speksin peptitlerinin siklooksijenaz (COX) ve araşidonat lipooksijenaz (ALOX) gen ekspresyonları üzerindeki etkisinin kronik renal yetmezlik ekseninde gelişen kardiyak hasarda incelenmesi amaçlanmıştır. Sıçanlarda Kronik Renal Yetmezlik (KRY) modeli 10 gün boyunca adenin hemisülfat çözeltisinin gavaj yoluyla verilmesiyle oluşturulmuştur. Speksin tedavisi için 35 µg/kg ve adropin tedavisi için 2,1 µg/kg dozlarda peptitler 4 hafta boyunca intramusküler olarak uygulanmıştır. Renal fonksiyonlar otoanalizör ile ölçülmüştür. Kardiyak dokudaki COX1, COX2, ALOX12 ve ALOX1

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Rao, Reena, Ming-Zhi Zhang, Min Zhao, et al. "Lithium treatment inhibits renal GSK-3 activity and promotes cyclooxygenase 2-dependent polyuria." American Journal of Physiology-Renal Physiology 288, no. 4 (2005): F642—F649. http://dx.doi.org/10.1152/ajprenal.00287.2004.

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The use of LiCl in clinical psychiatry is routinely complicated by overt nephrogenic diabetes insipidus (NDI), the mechanism of which is incompletely understood. In vitro studies indicate that lithium can induce renal medullary interstitial cell cyclooxygenase 2 (COX2) protein expression via inhibition of glycogen synthase kinase-3β (GSK-3β). Both COX1 and COX2 are expressed in the kidney. Renal prostaglandins have been suggested to play an important role in lithium-induced polyuria. The present studies examined whether induction of the COX2 isoform contributes to LiCl-induced polyuria. Four d

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Hao, Chuan-Ming, Martin Kömhoff, Youfei Guan, Reyadh Redha, and Matthew D. Breyer. "Selective targeting of cyclooxygenase-2 reveals its role in renal medullary interstitial cell survival." American Journal of Physiology-Renal Physiology 277, no. 3 (1999): F352—F359. http://dx.doi.org/10.1152/ajprenal.1999.277.3.f352.

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Renal medullary interstitial cells (MICs) are a major site of cyclooxygenase (COX)-mediated PG synthesis. These studies examined the role of COX in MIC survival. Immunoblot and nuclease protection demonstrate that cultured MICs constitutively express COX2, with little constitutive COX1 expression. SC-58236, a COX2-selective inhibitor, but not SC-58560, a COX1 inhibitor, preferentially blocks PGE2 synthesis in MICs. Transduction with a COX2 antisense adenovirus reduced MIC COX2 protein expression and also decreased PGE2production. Antisense downregulation of COX2 was associated with MIC death,

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Qorib, Mohammad Fathul, Abdul Khairul Rizki Purba, and Anette D'Arqom. "Dinamika Ekspresi Cox1 dan Cox2 Sebagai Landasan Tatalaksana Nyeri dan Inflamasi." Unram Medical Journal 11, no. 4 (2022): 1233–39. http://dx.doi.org/10.29303/jk.v11i4.4754.

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Sikolooksigenase (Cox) memiliki peran besar dalam berbagai fungsi fisiologis dan juga pada kondisi patologis yaitu inflamasi. Siklooksigenase berfungsi pada sintesa prostaglandin dari asam arachidonat , oleh sebab itu enzim ini juga disebut sebagai prostaglandin endoperoksidase H sintetase (PGH) Prostaglandin ini kemudian dapat menyebabkan berbagai perubahan biologis dalam tubuh meliputi vasodilatasi, peningkatan perfusi ginjal, produksi mukosa lambung, dan berbagai proses fisologis yang lain. Prostaglandin juga berperan pada proses patologis seperti inflamasi serta nyeri. Siklooksigenase memi

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Tan, Xiaoyu, Ellen Poulose, Bao-Ting Zhu, Daniel Stechschulte, and Kottarappat Dileepan. "Regulation of the expression of cyclooxygenases and production of PGI2 and PGE2 in human coronary artery endothelial cells by curcumin (142.5)." Journal of Immunology 184, no. 1_Supplement (2010): 142.5. http://dx.doi.org/10.4049/jimmunol.184.supp.142.5.

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Abstract Curcumin is a hydrophobic polyphenol present in turmeric (Curcuma longa). PGE2 and PGI2 are produced from arachidonic acid (AA) by the cyclooxygenases (COX1, COX2) and PGE2 synthase (PGE2S) and PGI2S. We evaluated the in vitro effect of CUR on COX1, COX2, PGI2S and PGE2S expression, and PGE2 and PGI2 production in human coronary artery endothelial cells (HCAEC). HCAEC were incubated with CUR (1.25-5.0 μM), and mRNA and protein expression were determined by qRT-PCR and Western blots, respectively. PGI2 and PGE2 levels in the culture supernatants were quantified by EIA. Incubation of HC

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Joy, Anit Treesa, Harish M, and Rishad K. S. "Anti-Inflammatory Activity of Phytoconstituents of Ginseng Plant- Insilico Approach." Biomedical and Pharmacology Journal 16, no. 2 (2023): 1179–88. http://dx.doi.org/10.13005/bpj/2698.

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Ginseng is a plant’s root of the Panax family that is characterized by the presence of ginsenosides. It is used as a traditional medicine for many years in East Asian regions generally as an adaptogenic medicine to make the body resistant to homeostasis and other adverse environmental factors. Inflammation and lipid signaling are intermixed modulators of homeostasis and immunity. Cyclooxygenase is a key enzyme in lipid signalling. The present study focused on the anti-inflammatory analysis of phytoconstituents of the ginseng plant against COX1 and COX2 genes. In this study we approached the st

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Stefanski, Casey D., Daniel A. Erkes, Timothy J. Purwin, et al. "Abstract A023: Arachidonic acid metabolism promoting cross resistance in melanoma cells." Cancer Research 84, no. 22_Supplement (2024): A023. http://dx.doi.org/10.1158/1538-7445.tumbody-a023.

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Abstract Melanoma patients initially respond well to first line immunotherapy. However, cross resistance to immunotherapy and BRAF/MEK inhibitor is a clinical challenge for melanoma care. To investigate drug tolerant and resistant mechanisms promoting cross resistance, we analyzed RNA-sequencing and gene set enrichment targeted therapy resistant melanoma cells revealing an enriched arachidonic acid gene signature. Intracellular arachidonic acid levels were increased in drug resistant and drug tolerant melanoma models. Arachidonic acid is enzymatically converted by COX1 and COX2 to prostaglandi

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Naithani, Sushma, Scott A. Saracco, Christine A. Butler, and Thomas D. Fox. "Interactions amongCOX1,COX2, andCOX3mRNA-specific Translational Activator Proteins on the Inner Surface of the Mitochondrial Inner Membrane ofSaccharomyces cerevisiae." Molecular Biology of the Cell 14, no. 1 (2003): 324–33. http://dx.doi.org/10.1091/mbc.e02-08-0490.

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The core of the cytochrome c oxidase complex is composed of its three largest subunits, Cox1p, Cox2p, and Cox3p, which are encoded in mitochondrial DNA of Saccharomyces cerevisiae and inserted into the inner membrane from the inside. Mitochondrial translation of the COX1,COX2, and COX3 mRNAs is activated mRNA specifically by the nuclearly coded proteins Pet309p, Pet111p, and the concerted action of Pet54p, Pet122p, and Pet494p, respectively. Because the translational activators recognize sites in the 5′-untranslated leaders of these mRNAs and because untranslated mRNA sequences contain informa

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Chen, Haolin, Lindi Luo, June Liu, and Barry R. Zirkin. "Cyclooxygenases in Rat Leydig Cells: Effects of Luteinizing Hormone and Aging." Endocrinology 148, no. 2 (2007): 735–42. http://dx.doi.org/10.1210/en.2006-0925.

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Previous studies suggested that increased Leydig cell cyclooxygenase (COX)2 expression may be involved in the reduced testosterone production that characterizes aged Leydig cells. Our objective herein was to further elucidate the relationships among LH stimulation, Leydig cell COX2 and COX1 expression, aging, and testosterone production. Incubation of Leydig cells from young or aged rats with LH or dibutyryl cAMP resulted in increases in both intracellular COX2 protein expression and testosterone production. COX1 expression did not respond to LH or dibutyryl cAMP. Incubation of adult cells wit

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Simanjuntak, Juniarto Gautama, Windra Priawandiputra, Rika Raffiudin, et al. "Apis cerana Fabricius, 1793 in Sumatra: Haplotype Variations of Mitochondrial DNA and the Molecular Relationship with the Asian Honey Bees (Hymenoptera: Apidae)." HAYATI Journal of Biosciences 31, no. 4 (2024): 768–80. http://dx.doi.org/10.4308/hjb.31.4.768-780.

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Honey bee Apis cerana is widely distributed in Asia and the Indonesian archipelago, including Sumatra. We studied the molecular variations of A. cerana using cytochrome c oxidase subunits 1 and 2 genes (cox1 and cox2) and the cox1/cox2 intergenic spacers (igs) in several altitudes in the six provinces of Sumatra. We explored the haplotype distributions of those three mtDNA markers for A. cerana in the low-, mid-, and highlands of Sumatra. We also analyzed their relationship with A. cerana in Sundaland and Asia using those markers. Our study revealed 12 new haplotypes of A. cerana cox1 in Sumat

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Wei, T., X. Zhang, J. Cui, L. N. Liu, P. Jiang, and Z. Q. Wang. "Levels of sparganum infections and phylogenetic analysis of the tapeworm Spirometra erinaceieuropaei sparganum in wild frogs from Henan Province in central China." Journal of Helminthology 89, no. 4 (2014): 433–38. http://dx.doi.org/10.1017/s0022149x14000248.

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AbstractSparganosis is a serious food-borne parasitic zoonosis caused by infection with Spirometra spargana. The prevalence of sparganum infection in wild frogs (Rana nigromaculata, R. limmochari, R. temporaria and Bufo gargarizans) was investigated in Henan Province of central China during 2008–2012. Of 3482 caught wild frogs, 565 (16.23%) were found to be infected with plerocercoids (spargana) of the genus Spirometra. Spargana were found in 14.85% (320/2155) of R. nigromaculata, 20.82% (233/1119) of R. limmochari and 10.91% (12/110) of R. temporaria frogs. However, no sparganum was found in

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Kennedy, Brian M., and Randall E. Harris. "Cyclooxygenase and Lipoxygenase Gene Expression in the Inflammogenesis of Colorectal Cancer: Correlated Expression of EGFR, JAK STAT and Src Genes, and a Natural Antisense Transcript, RP11-C67.2.2." Cancers 15, no. 8 (2023): 2380. http://dx.doi.org/10.3390/cancers15082380.

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We examined the expression of major inflammatory genes, cyclooxygenase-1, 2 (COX1, COX2), arachidonate-5-lipoxygenase (ALOX5), and arachidonate-5-lipoxygenase activating protein (ALOX5AP) among 469 tumor specimens of colorectal cancer in The Cancer Genome Atlas (TCGA). Among 411 specimens without mutations in mismatch repair (MMR) genes, the mean expression of each of the inflammatory genes ranked above the 80th percentile, and the overall mean cyclooxygenase expression (COX1+COX2) ranked in the upper 99th percentile of all genes. Similar levels were observed for 58 cases with MMR mutations. P

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Stiburek, Lukas, Katerina Vesela, Hana Hansikova, et al. "Tissue-specific cytochrome c oxidase assembly defects due to mutations in SCO2 and SURF1." Biochemical Journal 392, no. 3 (2005): 625–32. http://dx.doi.org/10.1042/bj20050807.

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The biogenesis of eukaryotic COX (cytochrome c oxidase) requires several accessory proteins in addition to structural subunits and prosthetic groups. We have analysed the assembly state of COX and SCO2 protein levels in various tissues of six patients with mutations in SCO2 and SURF1. SCO2 is a copper-binding protein presumably involved in formation of the CuA centre of the COX2 subunit. The function of SURF1 is unknown. Immunoblot analysis of native gels demonstrated that COX holoenzyme is reduced to 10–20% in skeletal muscle and brain of SCO2 and SURF1 patients and to 10–30% in heart of SCO2

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Ayhan, Sönmez, and Şimşek Tekin. "Investigation of the Effects of Cyclooxygenase I and Cyclooxygenase II Inhibitors on Angiogenesis in a Random-Pattern Rat Abdominal Skin Flap." International Journal of Current Medical and Biological Sciences 3, no. 1 (2023): 24–32. https://doi.org/10.5281/zenodo.7581676.

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<strong>Background:</strong>Cyclooxygenase (COX) inhibiting agents are already in use before, during and after flap surgery due to their analgesic and anti-inflammatory properties and they are known to improve flap viability. We have investigated the influence of COX1 and COX2 inhibitor drugs in the neoangiogenesis of random pattern flaps. <strong>Methods:</strong>Forty-eight rats were divided into 4 groups and their lateral based inguinal flaps measuring 3x3 cm were used as the experimental flap models. Group 1 was the control group so no agents were administered. In groups 2, 3 and 4; Celeco

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Stribinskis, Vilius, Guo-Jian Gao, Steven R. Ellis, and Nancy C. Martin. "Rpm2, the Protein Subunit of Mitochondrial RNase P in Saccharomyces cerevisiae, Also Has a Role in the Translation of Mitochondrially Encoded Subunits of Cytochrome c Oxidase." Genetics 158, no. 2 (2001): 573–85. http://dx.doi.org/10.1093/genetics/158.2.573.

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Abstract RPM2 is a Saccharomyces cerevisiae nuclear gene that encodes the protein subunit of mitochondrial RNase P and has an unknown function essential for fermentative growth. Cells lacking mitochondrial RNase P cannot respire and accumulate lesions in their mitochondrial DNA. The effects of a new RPM2 allele, rpm2-100, reveal a novel function of RPM2 in mitochondrial biogenesis. Cells with rpm2-100 as their only source of Rpm2p have correctly processed mitochondrial tRNAs but are still respiratory deficient. Mitochondrial mRNA and rRNA levels are reduced in rpm2-100 cells compared to wild t

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Jia, Yaning, Weixia Li, Yanlin Li, et al. "The Levels of Polycyclic Aromatic Hydrocarbons and Their Derivatives in Plasma and Their Effect on Mitochondrial DNA Methylation in the Oilfield Workers." Toxics 11, no. 5 (2023): 466. http://dx.doi.org/10.3390/toxics11050466.

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This study focuses on the components and levels of polycyclic aromatic hydrocarbons (PAHs) and their derivatives (MPAHs and OPAHs) in plasma samples from 19 oil workers, pre- and post-workshift, and their exposure–response relationship with mitochondrial DNA (mtDNA) methylation. PAH, MPAH, OPAH, and platelet mtDNA methylation levels were determined using a gas chromatograph mass spectrometer (GC-MS) and a pyrosequencing protocol, respectively. The total plasma concentrations of PAHs in mean value were, respectively, 31.4 ng/mL and 48.6 ng/mL in pre- and post-workshift, and Phe was the most abu

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Park, James L., Liming Shu та James A. Shayman. "Differential involvement of COX1 and COX2 in the vasculopathy associated with the α-galactosidase A-knockout mouse". American Journal of Physiology-Heart and Circulatory Physiology 296, № 4 (2009): H1133—H1140. http://dx.doi.org/10.1152/ajpheart.00929.2008.

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The lysosomal storage disorder Fabry disease is characterized by excessive globotriaosylceramide (Gb3) accumulation in major organs such as the heart and kidney. Defective lysosomal α-galactosidase A (Gla) is responsible for excessive Gb3 accumulation, and one cell sensitive to the effects of Gb3 accumulation is vascular endothelium. Endothelial dysfunction is associated with Fabry disease and excessive cellular Gb3. We previously demonstrated that excessive vascular Gb3 in a mouse model of Fabry disease, the Gla-knockout ( Gla−/0) mouse, results in abnormal vascular function, which includes a

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Tan, Xiaoyu, Arun Idiculla, Donald D. Smith, Daniel J. Stechschulte, and Kottarappat N. Dileepan. "Mast Cell Deficiency Leads to Decreased Expression of Cyclooxygenase-1 (COX1), COX2, Toll-Like Receptor-4 (TLR4) and Endothelial Nitric Oxide Synthase (eNOS) mRNA in Mouse Aorta (100.8)." Journal of Immunology 178, no. 1_Supplement (2007): S198. http://dx.doi.org/10.4049/jimmunol.178.supp.100.8.

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Abstract Mast cells (MC) are well known for their contribution to vascular inflammation and atherosclerosis. We have shown that MC proteases and histamine amplify lipopolysaccharide (LPS)-induced inflammatory responses in human coronary artery endothelial cells via stimulation of TLR4 expression. This study examined mRNA levels of COX1, COX2, TLR4 and eNOS in aortic tissues of MC-deficient (W/Wv) mice and wild type controls (WT) to gain insight into the role of MC in vascular pathophysiology. We also determined the effect of MC degranulation on gene expression in aortas 24 h after intraperiton

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Bestwick, Megan, Mi-Young Jeong, Oleh Khalimonchuk, Hyung Kim, and Dennis R. Winge. "Analysis of Leigh Syndrome Mutations in the Yeast SURF1 Homolog Reveals a New Member of the Cytochrome Oxidase Assembly Factor Family." Molecular and Cellular Biology 30, no. 18 (2010): 4480–91. http://dx.doi.org/10.1128/mcb.00228-10.

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ABSTRACT Three missense SURF1 mutations identified in patients with Leigh syndrome (LS) were evaluated in the yeast homolog Shy1 protein. Introduction of two of the Leigh mutations, F249T and Y344D, in Shy1 failed to significantly attenuate the function of Shy1 in cytochrome c oxidase (CcO) biogenesis as seen with the human mutations. In contrast, a G137E substitution in Shy1 results in a nonfunctional protein conferring a CcO deficiency. The G137E Shy1 mutant phenocopied shy1Δ cells in impaired Cox1 hemylation and low mitochondrial copper. A genetic screen for allele-specific suppressors of t

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Williams, Elizabeth H., Nada Bsat, Nathalie Bonnefoy, Christine A. Butler, and Thomas D. Fox. "Alteration of a Novel Dispensable Mitochondrial Ribosomal Small-Subunit Protein, Rsm28p, Allows Translation of Defective COX2 mRNAs." Eukaryotic Cell 4, no. 2 (2005): 337–45. http://dx.doi.org/10.1128/ec.4.2.337-345.2005.

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ABSTRACT Mutations affecting the RNA sequence of the first 10 codons of the Saccharomyces cerevisiae mitochondrial gene COX2 strongly reduce translation of the mRNA, which encodes the precursor of cytochrome c oxidase subunit II. A dominant chromosomal mutation that suppresses these defects is an internal in-frame deletion of 67 codons from the gene YDR494w. Wild-type YDR494w encodes a 361-residue polypeptide with no similarity to proteins of known function. The epitope-tagged product of this gene, now named RSM28, is both peripherally associated with the inner surface of the inner mitochondri

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Meshcheryakova, O. V., M. V. Churova, A. E. Veselov, and N. N. Nemova. "Activities of cytochrome c oxidase and mitochondrial lactate dehydrogenase isozymes and Cox1, Cox2, Cox4, and Cox6 gene subunit expression in cold adaptation of Salmo trutta L." Russian Journal of Bioorganic Chemistry 42, no. 2 (2016): 162–69. http://dx.doi.org/10.1134/s1068162016010106.

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Wang, Xiaoran, Weiqian Zhao, Minmin Zhuang, et al. "Population Genetic Structure of Sargassum horneri, the Dominant Species of Golden Tide in the Yellow Sea." Journal of Marine Science and Engineering 12, no. 6 (2024): 900. http://dx.doi.org/10.3390/jmse12060900.

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Sargassum horneri golden tides are increasingly becoming a marine ecological problem in the Yellow Sea (YS) and East China Sea. To understand the genetic relationship between the attached S. horneri along the China coast and the floating biomass in the YS, we used partial rbcL, ITS2, cox1, cox3, and cob-cox2 to analyze the population genetic evolution of 165 Sargassum samples. The results showed that all samples were a single species of S. horneri. Partial sequences of each gene had major haplotypes, and other haplotypes evolved from the occurrence of base mutations. The cob-cox2 gene haplotyp

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Fontanesi, Flavia, Iliana C. Soto, Darryl Horn, and Antoni Barrientos. "Mss51 and Ssc1 Facilitate Translational Regulation of Cytochrome c Oxidase Biogenesis." Molecular and Cellular Biology 30, no. 1 (2009): 245–59. http://dx.doi.org/10.1128/mcb.00983-09.

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ABSTRACT The intricate biogenesis of multimeric organellar enzymes of dual genetic origin entails several levels of regulation. In Saccharomyces cerevisiae, mitochondrial cytochrome c oxidase (COX) assembly is regulated translationally. Synthesis of subunit 1 (Cox1) is contingent on the availability of its assembly partners, thereby acting as a negative feedback loop that coordinates COX1 mRNA translation with Cox1 utilization during COX assembly. The COX1 mRNA-specific translational activator Mss51 plays a fundamental role in this process. Here, we report that Mss51 successively interacts wit

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Mohammed Al bratty, Mohammed Al bratty, Neelaveni Thangavel Neelaveni Thangavel, Hassan Ahmad Alhazmi Hassan Ahmad Alhazmi, et al. "Gas Chromatography-Mass Spectrometry-based Phytochemical Analysis and In-Vitro Anti-Lipid Peroxidation, Cyclooxygenase Inhibition Activities of Saudi Eruca sativa Leaves." Journal of the chemical society of pakistan 44, no. 2 (2022): 175. http://dx.doi.org/10.52568/001001/jcsp/44.02.2022.

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Eruca sativa is a wholesome yearly shrubbery herb in Saudi Arabia. Eruca sativa leaves are a conventional food and are consumed raw in salads. The present research reports the phytochemical analysis, in-vitro anti-lipid peroxidation, total anti-oxidant capability, cyclooxygenase-1, and -2 (COX1 and COX2) inhibition activities of Saudi Eruca sativa leaves water decoction (EWD). Gas chromatography-mass spectrometry (GC-MS) of EWD revealed seventeen constituents of six different chemical groups: phenolics (23.60%), aromatic and aliphatic esters (16.97%), terpenoids (31.91%), heterocyclics (14.83%

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Ouyang, Bowen, Yingying Li, Jieqiong Wang, Zhonghua Wei, and Aimin Shi. "The Complete Mitochondrial Genomes of Penthe kochi (Coleoptera: Tetratomidae) with Its Phylogenetic Implications." Current Issues in Molecular Biology 46, no. 10 (2024): 10795–805. http://dx.doi.org/10.3390/cimb46100641.

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To explore the mitogenome characteristics of Tetratomidae and the phylogenetic position of this family in Tenebrionoidea, the mitogenome of Penthe kochi Mařan, 1940 was sequenced, annotated, and analyzed. The P. kochi mitogenome is consistent with Tenebrionoidea species in gene length, genomic organization, codon usage, and secondary structures of transfer genes (tRNAs). Most protein-coding genes (PCGs) originate with a typical ATN start codon, except nad1 and nad3, which start with TTG. In total, 10 PCGs are terminated with complete stop codon TAA and TAG, while cox1, cox2, and nad 4 contain

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Jin, Xiaoxiao, Xiaojia Lin, Simeng Wang, and Jie Fang. "Complete Mitochondrial Genome of Chlorogomphus papilio (Odonata: Anisoptera: Chlorogomphidae) and Phylogenetic Analyses." Biology 14, no. 5 (2025): 493. https://doi.org/10.3390/biology14050493.

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This study aimed to elucidate the mitochondrial genome organization of Chlorogomphus papilio and the phylogenetic relationships of Chlorogomphidae. We used the Illumina MiSeq sequencing platform to sequence the mitochondrial genome of C. papilio, which was subsequently assembled, annotated, and analyzed. Bayesian inference, maximum likelihood, and maximum parsimony methods were employed to construct the mitochondrial phylogenetic tree of 25 species of Chlorogomphidae based on 16S rRNA and cox1 genes. We observed that the mitochondrial genome of C. papilio is 15,251 bp in length and includes 13

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Lim, Sung-Chul, Hyoin Hwang, and Song Iy Han. "Ellagic Acid Inhibits Extracellular Acidity-Induced Invasiveness and Expression of COX1, COX2, Snail, Twist 1, and c-myc in Gastric Carcinoma Cells." Nutrients 11, no. 12 (2019): 3023. http://dx.doi.org/10.3390/nu11123023.

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Extracellular acidity has been implicated in enhanced malignancy and metastatic features in various cancer cells. Gastric cancer cell lines (AGS and SNU601) maintained in an acidic medium have increased motility and invasiveness. In this study, we investigated the effect of ellagic acid, a plant-derived phenolic compound, on the acidity-promoted migration and invasion of gastric cancer cells. Treating cells maintained in acidic medium with ellagic acid inhibited acidity-mediated migration and invasion, and reduced the expression of MMP7 and MMP9. Examining regulatory factors contributing to th

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Nisztuk-Pacek, Sylwia, Brygida Ślaska, Ludmiła Grzybowska-Szatkowska, and Marek Babicz. "Paternal Leakage of Mitochondrial DNA in the Raccoon Dog (Nyctereutes Procyonoides Gray 1834)." Annals of Animal Science 19, no. 1 (2019): 61–69. http://dx.doi.org/10.2478/aoas-2018-0049.

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AbstractThe aim of the study was to describe the mechanism of mitochondrial DNA inheritance in a group of farmed raccoon dogs. The study involved 354 individuals. Whole peripheral blood was the research material. DNA was isolated and PCR was performed for two fragments of mitochondrial genes: COX1 (cytochrome oxidase subunit 1 gene) and COX2 (cytochrome oxidase subunit 2 gene). The PCR products were sequenced and subjected to bioinformatics analyses. Three mitochondrial haplotypes were identified in the COX1 gene fragment and two in the COX2 gene fragment. The analysis of mtDNA inheritance in

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Chen, Wen, Zeinab Robleh Djama, Michael D. Coffey, et al. "Membrane-Based Oligonucleotide Array Developed from Multiple Markers for the Detection of Many Phytophthora Species." Phytopathology® 103, no. 1 (2013): 43–54. http://dx.doi.org/10.1094/phyto-04-12-0092-r.

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Most Phytophthora spp. are destructive plant pathogens; therefore, effective monitoring and accurate early detection are important means of preventing potential epidemics and outbreaks of diseases. In the current study, a membrane-based oligonucleotide array was developed that can detect Phytophthora spp. reliably using three DNA regions; namely, the internal transcribed spacer (ITS), the 5′ end of cytochrome c oxidase 1 gene (cox1), and the intergenic region between cytochrome c oxidase 2 gene (cox2) and cox1 (cox2-1 spacer). Each sequence data set contained ≈250 sequences representing 98 des

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Liu, G. H., B. Li, J. Y. Li, et al. "Genetic variation among Clonorchis sinensis isolates from different geographic regions in China revealed by sequence analyses of four mitochondrial genes." Journal of Helminthology 86, no. 4 (2011): 479–84. http://dx.doi.org/10.1017/s0022149x11000757.

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AbstractThe present study examined sequence variation in four mitochondrial (mt) genes, namely cytochrome c oxidase subunits 1 (cox1) and 2 (cox2), and NADH dehydrogenase subunits 1 and 2 (nad1 and nad2) among Clonorchis sinensis isolates from different endemic regions in China, and their phylogenetic relationships with other zoonotic trematodes were reconstructed. A portion of the cox1 and cox2 genes (pcox1 and pcox2), and nad1 and nad2 genes (pnad1 and pnad2) were amplified separately from individual liver flukes by polymerase chain reaction (PCR) and the amplicons were subjected to sequenci

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Li, Yi, Jie Lin, Yong-Hui Wang, et al. "Complete mitochondrial genome of Pleurocordyceps sinensis (Hypocreales, Ascomycota), a species with uncertain family-level taxonomic assignment." Quality Assurance and Safety of Crops & Foods 14, no. 4 (2022): 212–26. http://dx.doi.org/10.15586/qas.v14i4.1134.

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The complete mitochondrial (mt) genome of the ex-type strain of Pleurocordyceps sinensis, a fungus originally isolated from Ophiocordyceps sinensis, was sequenced, and assembled as a single circular DNA of 31,841 bp. The mt genome encoded 15 conserved proteins (rps3, cox1, cox2, cox3, cob, atp6, atp8, atp9, nad1, nad2, nad3, nad4, nad4L, nad5, and nad6), 2 rRNA (rnl and rns), and 25 tRNA, as well as 10 additional non-conserved open reading frames (ncORFs). Comparative analyses showed that mt genomes within the order Hypocreales encoded the same number and synteny of conserved protein coding ge

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Zhang, Dan, Fei-Xiang He, Xue-Bo Li, Zhulidezi Aishan, and Xiao-Long Lin. "New Mitogenomes of the Polypedilum Generic Complex (Diptera: Chironomidae): Characterization and Phylogenetic Implications." Insects 14, no. 3 (2023): 238. http://dx.doi.org/10.3390/insects14030238.

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Mitochondrial genomics, as a useful marker for phylogenetics and systematics of organisms, are important for molecular biology studies. The phylogenetic relationships of the Polypedilum generic complex remains controversial, due to lack taxonomy and molecular information. In this study, we newly sequenced mitogenomes of 14 species of the Polypedilum generic complex. Coupled with three recently published sequences, we analyzed the nucleotide composition, sequence length, and evolutionary rate of this generic complex. The control region showed the highest AT content. The evolution rate of protei

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Dumilag, Richard Verano, and Arturo Lluisma. "Resolving the phylogenetic affinities of Kappaphycus inermis within the genus Kappaphycus (Gigartinales, Solieriaceae) using mitochondrial and plastid markers." Phytotaxa 162, no. 4 (2014): 223. http://dx.doi.org/10.11646/phytotaxa.162.4.5.

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Although the phylogeny of the genus Kappaphycus has been the subject of a number of published studies, the phylogenetic placement of Kappaphycus inermis within the genus has remained unresolved. In this study, we sought to determine the phylogenetic affinities of K. inermis with the other congeneric species using mitochondrial (cox1 and cox2–3 spacer) and plastid (rbcL and RuBisCo spacer) markers, using specimens collected from northwestern Philippines. Morphological observations of the collected materials confirmed the presence of key morphological features that distinguish K. inermis from th

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Odame, Emmanuel, Li Li, Joshua Abdulai Nabilla, et al. "miR-145-3p Inhibits MuSCs Proliferation and Mitochondria Mass via Targeting MYBL1 in Jianzhou Big-Eared Goats." International Journal of Molecular Sciences 24, no. 9 (2023): 8341. http://dx.doi.org/10.3390/ijms24098341.

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Muscle growth and injury-induced regeneration are controlled by skeletal muscle satellite cells (MuSCs) through myogenesis in postnatal animals. Meanwhile, myogenesis is accompanied by mitochondrial function and enzyme activity. Nevertheless, the underlying molecular mechanisms involving non-coding RNAs including circular RNAs (circRNAs) and microRNAs (miRNAs) remain largely unsolved. Here, we explored the myogenic roles of miR-145-3p and MYBL1 on muscle development and mitochondrial mass. We noticed that overexpression of miR-145-3p inhibited MuSCs proliferation and reduced the number of viab

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