Academic literature on the topic 'CPTX'
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Journal articles on the topic "CPTX"
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Suzuki, Kunimichi, Jonathan Elegheert, Inseon Song, et al. "A synthetic synaptic organizer protein restores glutamatergic neuronal circuits." Science 369, no. 6507 (2020): eabb4853. http://dx.doi.org/10.1126/science.abb4853.
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Neuronal synapses undergo structural and functional changes throughout life, which are essential for nervous system physiology. However, these changes may also perturb the excitatory–inhibitory neurotransmission balance and trigger neuropsychiatric and neurological disorders. Molecular tools to restore this balance are highly desirable. Here, we designed and characterized CPTX, a synthetic synaptic organizer combining structural elements from cerebellin-1 and neuronal pentraxin-1. CPTX can interact with presynaptic neurexins and postsynaptic AMPA-type ionotropic glutamate receptors and induced the formation of excitatory synapses both in vitro and in vivo. CPTX restored synaptic functions, motor coordination, spatial and contextual memories, and locomotion in mouse models for cerebellar ataxia, Alzheimer’s disease, and spinal cord injury, respectively. Thus, CPTX represents a prototype for structure-guided biologics that can efficiently repair or remodel neuronal circuits.
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Stearns, Mark E., Greg Kim, Fernando Garcia, and Min Wang. "Interleukin-10 Induced Activating Transcription Factor 3 Transcriptional Suppression of Matrix Metalloproteinase-2 Gene Expression in Human Prostate CPTX-1532 Cells." Molecular Cancer Research 2, no. 7 (2004): 403–16. http://dx.doi.org/10.1158/1541-7786.403.2.7.
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Abstract Aberrant expression of the 72-kDa type IV collagenase [matrix metalloproteinase (MMP)-2] is implicated in the invasion and angiogenesis process of malignant tumors. We investigated the effects of interleukin (IL)-10 on MMP-2 expression in CPTX-1532 human prostate tumor cells. Our results demonstrate that IL-10 significantly inhibited MMP-2 transcription and protein expression induced by a phorbol ester, phorbol 12-myristate 13-acetate. The inhibitory effects of IL-10 on MMP-2 expression correlated with the suppression of MMP-2 promoter activity. To determine the mechanism of IL-10 action, we examined IL-10–dependent promoter activity with luciferase constructs from a 2-kbp promoter region of the human MMP-2 gene. We functionally characterized the promoter fragments by transient transfection experiments with CPTX-1532 cells. The experiments revealed that a cAMP responsive element binding protein (CREB) consensus domain was identified upstream of the 5′ transcriptional start site, which was highly responsive to IL-10–dependent down-regulation of promoter luciferase activity. Electrophoretic mobility shift assays combined with antibody “supershift assays” confirmed the data from the luciferase assays. Immunoblot assays of activating transcription factor (ATF) 3 immunoprecipitates with tyrosine specific antibodies revealed that IL-10 stimulated tyrosine phosphorylation of ATF3 to activate binding to the CREB domain and suppress MMP-2 expression. Studies with stable, IL-10 transfected CPTX-1532 subclones further showed that IL-10 failed to suppress MMP-2 expression in ATF3-deficient CPTX-1532 cells, where the ATF3 mRNA was destroyed with a DNAzyme oligonucleotide targeting the 5′ region of the mRNA. Finally, reconstitution of ATF3 successfully restored the inhibitory effects of IL-10 on MMP-2 gene expression. Taken together, these data demonstrate the critical role of tyrosine phosphorylated ATF3 and the CREB consensus domain in IL-10 suppression of MMP-2 gene expression in primary human prostate tumor cells.
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Kapanci, Tugba, Sarah Merks, Thomas H. Rammsayer, and Stefan J. Troche. "On the Relationship between P3 Latency and Mental Ability as a Function of Increasing Demands in a Selective Attention Task." Brain Sciences 9, no. 2 (2019): 28. http://dx.doi.org/10.3390/brainsci9020028.
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The mental speed approach to individual differences in mental ability (MA) is based on the assumption of higher speed of information processing in individuals with higher than those with lower MA. Empirical support of this assumption has been inconsistent when speed was measured by means of the P3 latency in the event-related potential (ERP). The present study investigated the association between MA and P3 latency as a function of task demands on selective attention. For this purpose, 20 men and 90 women performed on a standard continuous performance test (CPT1 condition) as well as on two further task conditions with lower (CPT0) and higher demands (CPT2) on selective attention. MA and P3 latency negatively correlated in the standard CPT, and this negative relationship even increased systematically from the CPT1 to the CPT2 condition but was absent in the CPT0 condition. The present results indicate that task demands on selective attention are decisive to observe the expected shorter P3 latency in individuals with higher compared to those with lower MA.
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Guzmán, M., and M. J. H. Geelen. "Activity of carnitine palmitoyltransferase in mitochondrial outer membranes and peroxisomes in digitonin-permeabilized hepatocytes. Selective modulation of mitochondrial enzyme activity by okadaic acid." Biochemical Journal 287, no. 2 (1992): 487–92. http://dx.doi.org/10.1042/bj2870487.
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A procedure is described for the rapid measurement of the activity of mitochondrial-outer-membrane carnitine palmitoyltransferase (CPTo) and peroxisomal carnitine palmitoyltransferase (CPTp) in digitonin-permeabilized hepatocytes. CPTo activity was determined as the tetradecylglycidate (TDGA)-sensitive malonyl-CoA-sensitive CPT activity, whereas CPTp activity was monitored as the TDGA-insensitive malonyl-CoA-sensitive CPT activity. Under these experimental conditions, the respective contributions of CPTo and CPTp to total hepatocellular malonyl-CoA-sensitive CPT activity were 74.6 and 25.4%, which correlated well with the values of 76.9 and 23.1% for the respective contributions of the mitochondrial and the peroxisomal compartment to total hepatocellular palmitate oxidation. The sensitivity of CPTo to inhibition by malonyl-CoA was very similar to that of CPTp; thus 50% inhibition of CPTo and CPTp activities was achieved with malonyl-CoA concentrations of 2.6 +/- 0.5 and 3.0 +/- 0.4 microM respectively. Short-term incubation of hepatocytes with the phosphatase inhibitor okadaic acid (i) increased the activity of CPTo and the rate of mitochondrial palmitate oxidation, (ii) decreased the affinity of CPTo for palmitoyl-CoA substrate, and (iii) decreased the sensitivity of CPTo to inhibition by malonyl-CoA. By contrast, neither the properties of CPTp nor the rate of peroxisomal palmitate oxidation were changed upon incubation of cells with okadaic acid. Results indicate therefore that CPTo, but not CPTp, may be regulated by a mechanism of phosphorylation/dephosphorylation. The physiological relevance of these findings is discussed.
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Murthy, M. S., and S. V. Pande. "Some differences in the properties of carnitine palmitoyltransferase activities of the mitochondrial outer and inner membranes." Biochemical Journal 248, no. 3 (1987): 727–33. http://dx.doi.org/10.1042/bj2480727.
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Recent evidence has shown that the outer, overt, malonyl-CoA-inhibitable carnitine palmitoyltransferase (CPTo) activity resides in the mitochondrial outer membrane [Murthy & Pande (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 378-382]. A comparison of CPTo activity of rat liver mitochondria with the inner, initially latent, carnitine palmitoyltransferase (CPTi) of the mitochondrial inner membrane has revealed that the presence of digitonin and several other detergents inactivates CPTo activity. The CPTi activity, in contrast, was markedly stimulated by various detergents and phospholipid liposomes. These findings explain why in previous studies, which used digitonin or other detergents to expose, separate and purify the CPT activities, the inferences were drawn that (a) the ratio of latent to overt CPT was quite high, (b) both the CPT activities could be ascribed to one active protein recovered, and (c) the observed lack of malonyl-CoA inhibition indicated possible loss/separation of a putative malonyl-CoA-inhibition-conferring protein. Although both CPTo and CPTi were found to catalyse the forward and the backward reactions, CPTo showed greater capacity for the forward reaction and CPTi for the backward reaction. The easily solubilizable CPT, released on sonication of mitoplasts or of intact mitochondria under hypo-osmotic conditions, resembled CPTi in its properties. When octyl glucoside was used under appropriate conditions, 40-50% of the CPTo of outer membranes became solubilized, but it showed limited stability and decreased malonyl-CoA sensitivity. Malonyl-CoA-inhibitability of CPTo was decreased also on exposure of outer membranes to phospholipase C. When outer membranes that had been exposed to octyl glucoside or to phospholipase C were subjected to a reconstitution procedure using asolectin liposomes, the malonyl-CoA-inhibitability of CPTo was restored. A role of phospholipids in the malonyl-CoA sensitivity of CPTo is thus indicated.
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Silva, Filomena S. G., Irina G. Starostina, Vilena V. Ivanova, Albert A. Rizvanov, Paulo J. Oliveira, and Susana P. Pereira. "Determination of Metabolic Viability and Cell Mass Using a Tandem Resazurin/Sulforhodamine B Assay." Current Protocols in Toxicology 68, no. 1 (2016): 2.24.1–2.24.15. http://dx.doi.org/10.1002/cptx.1.
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Mahalingaiah, Prathap Kumar, Tammy Palenski, and Terry R. Van Vleet. "An In Vitro Model of Hematotoxicity: Differentiation of Bone Marrow-Derived Stem/Progenitor Cells into Hematopoietic Lineages and Evaluation of Lineage-Specific Hematotoxicity." Current Protocols in Toxicology 76, no. 1 (2018): e45. http://dx.doi.org/10.1002/cptx.45.
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Loelius, Shannon G., Sherry L. Spinelli, Katie L. Lannan, and Richard P. Phipps. "In Vitro Methods to Characterize the Effects of Tobacco and Nontobacco Products on Human Platelet Function." Current Protocols in Toxicology 76, no. 1 (2018): e46. http://dx.doi.org/10.1002/cptx.46.
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Smith, Andrew, Justin Dowis, and Deborah French. "Quantification of Serum Voriconazole, Isavuconazole, and Posaconazole by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)." Current Protocols in Toxicology 76, no. 1 (2018): e47. http://dx.doi.org/10.1002/cptx.47.
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Tamehiro, Norimasa, Reiko Adachi, Yoshie Kimura, Shinobu Sakai, Reiko Teshima, and Kazunari Kondo. "Determining Food Allergens by Skin Sensitization in Mice." Current Protocols in Toxicology 76, no. 1 (2018): e48. http://dx.doi.org/10.1002/cptx.48.
Full textDissertations / Theses on the topic "CPTX"
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Gustafson, Ellen, and Emelie Strömgren. "Cone Penetration Test - a comparative study of the equipment and the performance." Thesis, Linköpings universitet, Kommunikations- och transportsystem, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-121130.
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Inom geotekniken behövs ofta jordlagerföljden och jordens egenskaper bedömmas. För att göra detta används ofta sonderingsmetoden Cone Penetration Test (CPT), som används främst till att ge en preliminär bedömning av jordlagerföljden och en uppskattning av geotekniska egenskaper. CPT-sondering är en avancerad metod som ställer högre krav på både fältgeotekniker och handläggande geotekniker jämfört med andra metoder och är en metod där många faktorer påverkar resultatet. Detta examensarbete undersöker vilka faktorer som påverkar CPT-sondering med fokus på utrustning och handhavandet hos teknikkonsultföretaget WSP i Östergötland. Syftet med arbetet är att jämföra och utvärdera metod och resultat hos WSP för att se om det finns några skillnader i handhavandet och mellan de tre olika sonderna som är använda i studien. I studien utfördes 12 stycken CPT-sonderingar i samma område och dessa utfördes av samma fältgeotekniker, där häften av sonderingarna var utförda med förborrning och vattenfyllt sonderingshål och den andra hälften utförda med endast förborrning. Dessutom utfördes en skruvprovtagning i området. När sonderingarna var gjorda utvärderades resultaten i programvaran Conrad. Sonderingarna utfördes i ett område mellan Vånga och Göten, väster om Norrköping och området består främst av silt med lager av sand. Resultatet av studien visar att sond A har de jämnaste resultaten och orsaken till detta är troligtvis att denna sond är den som senast har kalibrerats. Efter sondering 2-C upptäcktes en skada på friktionshylsan för sond C, friktionshylsan byttes ut och trots detta ser resultatet för denna sond bra ut. Den första sonderingen gjord efter byte av friktionshylsan avviker dock i resultatet jämfört med de andra sonderingarna gjorda med sond C. Resultatet från sond B visar att denna sond uppnår lägre värde jämfört med de andra sonderna. En orsak till detta anses vara att denna sond är den sond som är kalibrerad med det tidigaste datumet. Slutsatsen i studien är att de faktorer som påverkar resultatet mest är kalibrering, att sonden är vätskemättad och att kontroller har utförts av sonden innan och efter sonderingen.
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Souza, Leandro Moreno de. "Software para análise e interpretação de resultados de ensaios CPT e CPTu." Universidade Federal de Viçosa, 2017. http://www.locus.ufv.br/handle/123456789/10843.
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Previous issue date: 2017-02-24<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>A busca por investigações geotécnicas precisas para o reconhecimento dos maciços de solo tornaram-se cada vez mais indispensáveis e ocupam um papel fundamental na Engenharia Civil, sendo que as investigações são realizadas em laboratório ou em campo. Um dos exemplos de ensaios de campo, o CPT – Cone Penetration Test, é constituído por um sistema de cravação semicontínua no solo de um conjunto de tubos e hastes de aço dotado de uma ponta cônica. Através deste procedimento, a estimativa e determinações da natureza, sequência e propriedades de engenharia das camadas subsuperficiais de solo podem ser realizadas. Considerando a falta de ferramentas computacionais que realizam a interpretação e analise do ensaio CPT e CPTu em língua portuguesa, esse trabalho visa suprir a carência de ferramentas computacionais para a análise e interpretação dos resultados do ensaio CPT e o procedimento para a construção da plataforma digital, denominado iCPT, foi utilizada a ferramenta Borland Delphi 7.0. Com os resultados obtidos dos ensaios CPT/CPTu, os mesmos foram comparados e confrontados com os resultados fornecidos pelos ensaios SPT, DMT e ensaios de laboratório realizados através de amostras e furos de sondagens, localizados no Campo Experimental de Engenharia Civil da Universidade Federal de Viçosa em Minas Gerais, em estudos previamente realizados por MINETTE et al. (1995), LOPES (1997), MONTEIRO (1999), ALMEIDA (2000) e DA SILVA (2000). Com os resultados encontrados através das comparações, constatou-se que: (i) para efeito de classificação do solo através do uso de ábacos de classificação, houve algumas camadas que apresentaram similaridade com outros métodos de campo ou de laboratório; (ii) quanto à determinação de propriedades geotécnicas através de correlações propostas, observou-se que: (a) o peso específico, teve uma proximidade dos valores daqueles aferidos em laboratório; (b) no caso de valores de OCR através de ensaios de laboratório para aqueles oferecidos pelo iCPT, há uma diferença entre os mesmos; e (c) quanto à determinação do ângulo de atrito os valores se mostraram próximos em comparação aos ensaios de compressibilidade; (iii) com relação a parte gráfica e visual, os resultados do iCPT apresentaram um ambiente agradável e eficiente.<br>The search for geotechnical investigations for the recognition of the massive form of soil became increasingly more vital and play a role based on Civil Engineering, being that the investigations are carried out in the laboratory or in the field. One of the examples of field trials, the CPT Cone Penetration Test, it is comprised of a system of inserting semi in the soil of a set of tubes and steel rods with a conical tip. Through this procedure, the estimation and determination of the nature, sequence and properties of engineering of subsurface layers of soil can be carried out. Considering the lack of computational tools that perform the interpretation and analysis of the test CPT and CPTu in portuguese, this study aims to overcome the lack of computational tools for the analysis and interpretation of the results of the test CPT and the procedure for the construction of the digital platform, called iCPT, was used the tool Borland Delphi 7.0. With the result obtained for testing CPT/CPTu, they were compared and confronted with the results provided by the tests SPT, DMT and laboratory tests performed through samples and drilling of probes, located in the Experimental Field of Civil Engineering at the Federal University of Viçosa in Minas Gerais, in studies previously conducted by MINETTE et al. (1995), Lopes (1997), Monteiro (1999), Almeida (2000) and Silva (2000). With the results found by the comparisons, it was found that: (i) for the purpose of soil classification through the use of charts of classification, there were some layers that showed similarity with other methods of field or laboratory; (ii) for determination of geotechnical properties through correlations proposals, it was observed that: (a) the specific weight, had a closeness of the values of those measured in the laboratory; (b) in the case of values of OCR through laboratory testing to those offered by the iCPT, there is a difference between them; and (c) regarding the determination of the angle of friction values are shown next in comparison to the tests of compressibility; (iii) with respect to the graphics and visual, the results of the iCPT presented a pleasant and efficient.
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Souza, Jeffson Murilo Santos de. "A influência da compacidade das areias nas correlações entre os ensaios de cone e o SPT." Universidade do Estado do Rio de Janeiro, 2009. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=1103.
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Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro<br>Correlations between the results from cone and SPT in sands are established in the present research for different sand densities. Such proposition is based on the experience obtained with the use of piezocone whose penetration in sands occurs commonly in drained condition. The SPT penetration, on the other hand, is much faster, occurring in a partially drained condition. The results confirm distinct correlations for different sand densities. The qc/NSPT ratio of 0,6MPa for sands, obtained from Danziger and Velloso (1986, 1995), for the whole data, is consistent with the value obtained in the present research if no distinction of density is made. If distinct density range is considered, the qc/NSPT ratio was found to be 1,1; 0,8; 0,6 and 0,5MPa, respectively for very loose, loose, medium and dense sands. Such results have repercussion on foundation design, as long as the most common methods applied in design make use of correlations between the CPT and SPT results. While the traditional correlations depend only on soil granulometry, the results presented in this research show that the relative density is of fundamental importance and must be also considered. In relation to the friction ratio, no tendency of variation with the relative density of sand has been observed, as expected, as long as both fs and qc are obtained from the cone. The results obtained with Palacios
(1977) data, with liner removal, and also the comparison between the resistance mobilized during the SPT sampler penetration evaluated by Schmertmann (1979) and Aoki et al. (2004) show that sampler plugging in sand probably does not occur.<br>Nesta pesquisa são estabelecidas correlações entre os resultados de ensaios de cone (CPT) e de SPT em areias, para diferentes faixas de compacidade. A proposta se fundamenta em experiência com o ensaio de piezocone, que ocorre quase sempre nas areias em condições drenadas. A realização do SPT se dá a maiores velocidades, em condição parcialmente drenada. Os resultados confirmam diferentes correlações para diferentes compacidades. Verificou-se que o valor 0,6MPa da relação qc/NSPT para areias, indicado por Danziger e Velloso (1986,1995), para os dados globais, é consistente com a média da faixa indicada nesta dissertação. Considerando-se as diferentes faixas de compacidade os valores encontrados de qc/NSPT foram de 1,1; 0,8; 0,6; 0,5MPa, respectivamente para areias fofas, pouco compactas, medianamente compactas e compactas. Tais resultados têm repercussão no projeto de fundações, em que métodos de projeto utilizam correlações entre os resultados de SPT e CPT. Enquanto nas correlações tradicionais os valores de qc/NSPT são função apenas da granulometria, os resultados apresentados mostram que a compacidade relativa tem importância fundamental, devendo ser também considerada. Em relação à razão de atrito, não se observou tendência de variação com a compacidade, conforme esperado, pois tanto fs como qc são obtidos do cone. Os resultados obtidos com os dados de Palacios (1977), com a remoção do liner, bem como a comparação entre os valores da força resistente à penetração do amostrador, a partir da interpretação de Schmertmann (1979) e Aoki et al. (2004), sinalizam para o não embuchamento do amostrador quando da sua penetração em areias.
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Rydman, Oskar. "Integration of Borehole, Ground, andAirborne Data to Improve Identificationof Areas With Quick Clays in Sweden." Thesis, Uppsala universitet, Geofysik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-445689.
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The main focus of the project was the comparison of results from a new towed transientelectromagnetic (tTEM) data set with existing data including airborne transient EM(ATEM), radio magnetotellurics (RMT), cone penetration test with resistivity (CPT-R),geotechnical interpretations and geological observations in a quick clay landslide site atFråstad close to Lilla Edet in south-west Sweden. The tTEM data set was processedand inverted twice in the software Aarhus workbench using different inversion constraintsand settings. The resulting resistivity models where compared with previous geophysicalmodels based on both ATEM and RMT as well as geotechnical information in the form ofborehole logs and CPTR measurements. The results compared well with all other modelsand predicts resistivities in the range of 10−40Ωmin areas of interpreted to hold quickclay by geotechnical methods. As a ground geophysical method the tTEM method is fastand cost-effective, particularly in more open areas with little topographical variations. Inthe example presented in this study tTEM measurements are deemed an effective andaccurate tool to map areas of potential quick clay using the inverted resistivity models incombination with other geological and geotechnical data.<br>Huvudsyftet med detta projekt är en sammanställning och jämförelse mellan resistivitetsmod-eller från ett nytt markburet TEM data set (tTEM) och tidigare insamlade luftburnaTEM data (ATEM), RMT (radiomagnetotellurik) samt detaljerade resistivitetsmätningari borrhål (CPT-R). Mätområdet ligger i Fråstad vid Göta älv i Lilla Edets kommun isydvästra Sverige. Tidigare undersökningar har visat att området innehåller kvickleraoch där förekommer även skredärr från tidigare kvickleraskred. tTEM datan bearbe-tades,filtrerades och inverterades med hjälp av mjukvaran Aarhus workspace med tvåolika set av begränsningar och inställningar. De resulterande resistivitetsmodellerna jäm-fördes med tidigare geofysiska metoder i ATEM och RMT samt med geoteknisk infor-mation i formen av borrhålsloggar samt CPTR mätningar. Resultatet visar en mycketgod korrelation mellan resistivitetsmodellerna från de olika dataseten. De modelleraderesistiviteterna var 10−40Ωm för de områden som med geotekniska metoder identifieratssom kvickleraområden. Som en markbunden metod är tTEM snabb och kostnadseffektiv,särskilt vid användning i öppna ytor med liten topografisk variation. I exemplen somvisas i denna studie dras slutsatsen att tTEM är ett effektivt och noggrant verktyg föratt hitta områden som potentiellt kan hålla kvickleror. Där kan sedan de resulteranderesistivitetsmodellerna användas tillsammans med annan geoteknisk och geologisk dataför att effektivt kartlägga dessa kvicklersområden.
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Kardan, Caesar. "Quality of CPTU : Analyses and comparison of data from commercial actors in Stockholm/Mälardalen." Thesis, KTH, Jord- och bergmekanik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-161222.
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CPTU is one of the most sophisticated geotechnical investigation methods. However, there is a large amount of uncertainties related to this method. The uncertainties depend on different types of factors, for instance lack of accuracy in performance and equipment. The objective of this master thesis is to compare the CPTU-results from a number of commercial actors in Stockholm/Mälardalen in order to analyze these results with respect to the current standards and guidelines. The comparison was made in order to highlight the difference in results which may appear due to different equipment, performance of the operator and evaluation method. Based on this, an invite was sent to the commercial actors in Stockholm/Mälardalen, resulting in the participation of five different commercial actors in this investigation. Execution in the field was conducted over a six week period. During this time 26 CPTU were performed in total in a small area in Hagby, Stockholm, by these different actors. Once the data was collected from all of the actors, the results were evaluated with the aid of the computer softwares Conrad and Excel. The main conclusions from this study are: Not one of the performed CPTU in this master thesis fulfills the requirements for CPT class 1 according to the European standards. The quality of the education of operators should be improved and geotechnical engineers and the clients need to be more familiar with CPTU. The evaluated results from different commercial actors differ, and this can depend on the choice of equipment and performance of the operator during penetration, but it can also depend on systematic errors in the cone penetrometers<br>CPTU-sonderingar är en av de mest sofistikerade undersökningsmetoderna för geoteknisk analys och bedömning. Det finns emellertid en hög grad av osäkerhet i denna metod. Osäkerheten beror på olika typer av faktorer, bland annat brist på noggrannhet i handhavande och utrustning. Syftet med detta examensarbete är att jämföra CPTU-resultat från de kommersiella aktörerna i Stockholm/Mälardalen för att senare analysera dessa resultat i förhållande till gällande ramverk och riktlinjer. Jämförelsen gjordes med avsikt att lyfta fram skillnaderna i resultat som kan uppstå på grund av olika utrustning, handhavande och utvärderingsmetod. Baserat på detta skickades en inbjudan till de kommersiella aktörerna i Stockholm/Mälardalen, vilket ledde till att fem olika kommersiella aktörer deltog i undersökningen. Utförande i fält genomfördes under en period på sex veckor. Under denna tid utfördes totalt 26 sonderingar i ett avgränsat område i Hagby, Stockholm, av dessa olika aktörer. När all data samlats in från alla aktörer utvärderades resultaten med hjälp av mjukvarorna Conrad och Excel. De viktigaste slutsatserna i denna studie är: Ingen utav de utförda CPTU-sonderingarna uppfyller kraven för CPT klass 1 enligt den europeiska standarden. Kvaliteten på utbildning av fältgeotekniker bör förbättras och geotekniska ingenjörer och även beställare bör bli mer bekanta med CPT. De utvärderade resultaten från de olika aktörerna skiljer sig åt, och detta kan bero på valet av utrustning och fältgeoteknikerns prestation vid sondering men det kan också bero på systematiska fel i de använda sonderna.
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Pujol, Vidal Maria Magdalena. "Relació estructura-funció de les proteïnes CPT1." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/83864.
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L’enzim Carnitina palmitoïltransferasa 1 (CPT1) permet l’entrada dels àcids grassos de cadena llarga a la matriu mitocondrial per tal de ser degradats i utilitzats així com a substrat energètic. El malonil-CoA, primer intermediari en la síntesi d’àcids grassos, és un inhibidor al•lostèric de CPT1, fet que permet una regulació coordinada entre la síntesi i l’oxidació d’àcids grassos en un mateix teixit, evitant així que es donin ambdós processos alhora. Una inhibició específica de CPT1, doncs, és una bona aproximació farmacològica per al tractament de desordres metabòlics que impliquin acumulació d’àcids grassos i resistència a insulina, com la diabetis tipus 2 i l’obesitat.
La present tesi doctoral s’ha centrat en l’estudi de la regulació per malonil-CoA dels isotips hepàtic (CPT1A) i muscular (CPT1B) de CPT1, així com en l’estudi de l’isotip més recentment descrit de la proteïna d’expressió en cervell, CPT1C. Per tal d’aprofundir en l’estudi de determinants moleculars de CPT1 que marquen el seu grau d’inhibició per malonil-CoA, s’han realitzat construccions mutants i delecionades dels enzims CPT1A i CPT1B i s’han expressat en el llevat “Pichia pastoris”. Mitjançant l’anàlisi del paràmetre IC50, hem demostrat que la regió aminoterminal de l’enzim CPT1A de rata (residus 1-18) exerceix un efecte dominant sobre les posicions Glu590 i Met593 en determinar la sensibilitat a la inhibició per malonil-CoA. Paral•lament, s’han generat construccions amb la seqüència de l’enzim CPT1 de porc, que presenta una gran diferència en el seu comportament enzimàtic quan es compara amb l’enzim humà, tant l’isotip hepàtic com el muscular. En aquest treball s’ha identificat l’existència d’un determinant negatiu en la posició Glu17 que explica parcialment la menor sensibilitat d’aquest enzim a la inhibició pel malonil-CoA. A més a més, s’ha construït un model 3-D in silico de la CPT1B humana, que permet justificar observacions experimentals mostrades en aquest treball, tot i que no explica encara les diferències en el comportament cinètic entre els isotips hepàtics i musculars de la proteïna. CPT1C és l’isotip descrit més recentment, i encara avui se’n desconeix la seva funció, existeix controvèrsia respecte a la seva distribució subcel•lular i no se n’han descrit els mecanismes que en regulen l’expressió. Els resultats mostrats en aquest treball demostren que CPT1C és una proteïna sense activitat enzimàtica, independentment de la característica extensió C-terminal que presenta respecte els altres isotips. D’altra banda, el patró d’expressió observat del gen Cpt1c no és compatible amb el paper que se li ha atorgat sobre la regulació de la ingesta. A més a més, hem identificat l’expressió d’una isoforma soluble de CPT1C en cervell humà adult, que ofereix una eina útil per a l’obtenció d’un cristall de la regió C-terminal citosòlica de CPT1C.<br>STRUCTURE-FUNCTION RELATIONSHIP OF CPT1 PROTEINS
CPT1 (Carnitine palmitoyltransferase 1) enables the entry of long chain fatty acids into the mitochondrial matrix, in order to be degraded and used as energetic substrate. Malonyl-CoA, the first intermediate in the synthesis of fatty acids, is an allosteric inhibitor of CPT1. Through CPT1 inhibition, it establishes a coordinated regulation between fatty acid synthesis and oxidation, thus preventing that both pathways coexist at the same time. A specific inhibition of CPT1 is therefore a good approximation or the pharmacological treatment of metabolic disorders involving accumulation of fatty acids and nsulin resistance, such as type-2 diabetes and obesity.
This thesis has focused on the study of malonyl-CoA regulation of both CPT1A and CPT1B isotypes. In addition, we studied the more recently described isotype of the protein, CPT1C. To gain insight into the study of CPT1 molecular determinants of malonyl-CoA inhibition, mutants of both CPT1A and CPT1B enzymes were expressed in yeast Pichia pastoris. Analysis of the IC50 parameter, demonstrated that the aminoterminal region (residues 1-18) of the rat CPT1A enzyme has a dominant effect over Glu590 and Met593 positions in determining its sensitivity to malonyl-CoA inhibition. We also identified the existence of a negative determinant within the sequence of pig CPT1A (position Glu17), which partially explains the low sensitivity of this enzyme to malonyl-CoA inhibition. In addition, we designed an in silico 3-D model of human CPT1B, which still does not explain the kinetic differences between liver and muscle isotypes of the protein, but justifies some of our experimental data. CPT1C is the more recently described isotype of the protein. Its function still remains unknown, and controversy exists regarding its subcellular distribution and the mechanisms that regulate its expression. Here we show that CPT1C is a protein without enzymatic activity, regardless of its characteristic C-terminal extension, compared to the other isotypes. Moreover, the observed gene expression pattern is not compatible with its given role on the regulation of food intake. In addition, we identified the expression of a soluble isoform of CPT1C in human adult brain, providing a useful tool for obtaining a crystalline structure of the cytosolic C-terminal region of CPT1.
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Mjöberg, Mårten, and Axel Stenfors. "CPTu Configuration Impact on Evaluated Undrained Shear Strength." Thesis, KTH, Jord- och bergmekanik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-279465.
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This thesis evaluates the commonly used geotechnical probing method CPTu, on how different probe configurations impact the resulting evaluated undrained shear strength in soft clay deposits, in comparison to each other and laboratory methods. This is done by performing field investigations on Lindefältet, Södermanlands län, Sweden. Comparison is done on the two Swedish manufacturers of CPTu probes, by different calibration limits, filter types and whether overloading the probe over the calibration limit affects the evaluated undrained shear strength registered. The main conclusions are that one of the manufacturers’ probes registers deviating results in one configuration, that calibration limit has a noticable impact on the results, and that overloading on the probe and filter choice has negliable impact on the results.<br>I detta examensarbete utvärderas den vanligt förekommande geotekniska sonderingsmetoden CPTu, på hur olika konfigurationer av sonder påverkar den resulterande utvärderade odränerade skjuvhållfastheten i lösa leravlagringar, 9i jämförelse med varandra och med laboratoriemetoder. Detta är genomfört genom fältundersökningar på Lindefältet, Södermanlands län. Jämförelsen gjordes på de två svenska CPTu-tillverkarnas sonder. Detta är gjort med hänsyn till olika kalibreringar av konspetstryck, filtertyper, och huruvida sonden har varit överlastad påverkar den utvärderade skjuvhållfastheten som registreras. De huvudsakliga slutsatserna är att en av tillverkarnas sonder registerar udda värden i en konfiguration, att kalibreringar av konspetstryck har en märkbar påverkan på de resulterande värdena på utvärderade odränerade skjuvhållfastheten, samt att överlastning av sonder och val av filtertyp har liten till omärkbar påverkan på resultatet.
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Ozkahriman, Fatma. "Cpt Based Compressibilty Assessment Of Soils." Master's thesis, METU, 2004. http://etd.lib.metu.edu.tr/upload/12605144/index.pdf.
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One of the most critical problems geotechnical engineers face with is the determination of the amount of consolidation settlement that will occur at a site as a result of the construction of a structure. The compressibility behavior of the soil is an important parameter in determining the amount of consolidation settlement.
The goal of this study is to develop probabilistically based correlation between the compressibility behavior of soil and in-situ test data. Within the scope of this research effort, performed CPT tests and the recorded settlement case histories where consolidation settlements at the field under various surcharge loads were compiled from the Bursa East and West Waste Water Treatment Plant soil investigation projects. A database was composed of the results of 45 CPT and 57 settlement plate recordings. For the compilation of this database, a series of finite difference
software FLAC-3D analyses were carried out to calculate the change in stress distribution under the settlement plates. A maximum likelihood framework was used for the development of compressibility behavior of soils.
As a result of careful processing of available data, the cone tip resistance (qc), soil behavior type index (Ic) were selected as two important parameters effecting the value of the one-dimensional constraint modulus, M. The regression
analysis which uses the settlement values recorded at the site and those computed using the change in the stress distribution, the thickness of the sublayers and the
proposed one-dimensional constraint modulus were carried out to calculate the values of these model parameters. Two correlations based on the cone tip resistance and soil behavior type index were developed for the computation of the one-dimensional constraint modulus, M.
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Schimmel, Jörn [Verfasser]. "CPT Verletzung und chirale Gittereichtheorie / Jörn Schimmel." Aachen : Shaker, 2003. http://d-nb.info/1181601738/34.
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anderson, David L. "Studies in CPT violation and 331 models." W&M ScholarWorks, 2006. https://scholarworks.wm.edu/etd/1539623495.
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The Standard Model of particles and fields has been around for about 30 years, and has been remarkably successful. However, it is widely believed to be incomplete, and theorists have studied various extensions to the model. These extensions can take many forms. An example of this is the framework Colladay and Kostelecky have proposed for studying Lorentz and CPT violation in a natural extension of the Standard Model. We determined the first bounds on the parameters in the Higgs sector. The bounds on the CPT---even asymmetric coefficients arise from the one-loop contributions to the photon propagator, those from the CPT---even symmetric coefficients arise from the equivalent cmunu coefficients in the fermion sector, and those from the CPT odd coefficient arise from bounds on the vacuum expectation value of the Z-boson. It is also interesting to look at the gauge structure of the Standard Model, and determine new effects that may arise if it is altered. One way to do this is to extend the SU(3)c x SU(2) L x U(1)Y gauge group to SU(3)c x SU(3)L x U(1) X, or what is called a 331 model. We studied variants of these models which are characterized by each lepton generation having a different representation under the gauge group. Flavor-changing neutral currents in the lepton sector occur in these models. to satisfy constraints on mu → 3e decays, the Z' must be heavier than 2 to 40 TeV, depending on the model and assignments of the leptons. These models can result in very unusual Higgs decay modes. In most cases the mutau decay state is large (in one case, it is the dominant mode), and in one case, the phi → ss?» rate dominates. Finally, it is possible to combine these approaches. This is particularly tempting in the currently exciting field of neutrino phenomena, where a combination of the 331 model with CPT-violating terms provides the terms necessary to explain the LSND anomaly, as well as the atmospheric and solar neutrino data. We also find predictions for relationships between the neutrino masses.
Books on the topic "CPTX"
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Foley, Ciaran P. Investigation into the affairs of Siúcre Éireann CPT and related companies. Stationery Office, 1990.
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Companhia Paulista de Trens Metropolitanos., ed. CPTM: Primeiros 10 anos. CPTM, 2002.
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Curran, Maurice R. Siúicre Éireann c.p.t. ...: Investigation under Section 14 of the Companies Act, 1990 : final report. Stationery Office, 1991.
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Office, Ireland Stationery, ed. Siuicre Eireann Cpt & related companies: First interim report of the court appointed inspectors. Stationery Office, 1991.
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Association, American Medical. Stedman's CPT dictionary. 2nd ed. American Medical Association, 2010.
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Association, American Medical. Stedman's CPT dictionary. 2nd ed. American Medical Association, 2010.
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Ursula, Vogel-Weidemann, Scholtemeijer Jan, and Naudé, C. P. T. 1912-, eds. Charistion CPT Naudé. University of South Africa, 1993.
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Association, American Medical, ed. Stedman's CPT dictionary. American Medical Association, 2007.
Find full textBook chapters on the topic "CPTX"
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Lutenegger, Alan J. "Cone Penetration (CPT) and Piezocone (CPTU) Tests." In In Situ Testing Methods in Geotechnical Engineering. CRC Press, 2021. http://dx.doi.org/10.1201/9781003002017-4.
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Monnet, Jacques. "Penetrometer Test (CPT, CPTU, SPT, DCPT) and Variants." In In Situ Tests in Geotechnical Engineering. John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781119145592.ch7.
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Peuchen, J., W. van Kesteren, V. Vandeweijer, S. Carpentier, and F. van Erp. "Upscaling 1 500 000 synthetic CPTs to voxel CPT models of offshore sites." In Cone Penetration Testing 2022. CRC Press, 2022. http://dx.doi.org/10.1201/9781003329091-93.
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Peuchen, J., W. van Kesteren, V. Vandeweijer, S. Carpentier, and F. van Erp. "Upscaling 1 500 000 synthetic CPTs to voxel CPT models of offshore sites." In Cone Penetration Testing 2022. CRC Press, 2022. http://dx.doi.org/10.1201/9781003308829-93.
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Kiefer, Claus. "CPT Theorem." In Compendium of Quantum Physics. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-70626-7_42.
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Peters, Nils, Martin Dichgans, Sankar Surendran, et al. "CPT-I." In Encyclopedia of Molecular Mechanisms of Disease. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_7417.
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Peters, Nils, Martin Dichgans, Sankar Surendran, et al. "CPT-A." In Encyclopedia of Molecular Mechanisms of Disease. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_7418.
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Díaz-Orueta, Unai. "Advances in Neuropsychological Assessment of Attention." In The Role of Technology in Clinical Neuropsychology. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190234737.003.0012.
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Attention is one of the most basic cognitive processes and is a prerequisite for the use of more complex functions, since it is not possible to evaluate perception or memory processes without keeping in mind attention issues (Amador, Forns, & Kirchner, 2006). The ability to maintain an appropriate level of attention is basic for education and learning, especially during childhood and school age. With the aim of studying attention separately from other cognitive functions, the so-called continuous performance tests (CPT) were created. The first series of CPTs were developed by Rosvold, Mirsky, Sarason, Bransome, and Beck (1956) to study vigilance in adults with acquired brain injury (Riccio, Reynolds, & Lowe, 2001), more specifically, persons with seizures (Amador, Forns, & Kirchner, 2006). Nowadays, CPTs are still one of the most widely used measures for the assessment of attention and processing speed. Briefly, it can be said that a CPT is a group of paradigms to evaluate attention, inhibitory response or disinhibition (a component of executive control that provides information about the subject’s impulsivity), and processing speed. Basically, CPTs rely on the rapid, random presentation of a series of stimuli to which the subject must respond following instructions given at the beginning of the test. The main value of CPTs is their empirical support. Diverse CPT paradigms have consistently demonstrated their sensitivity for a great variety of both neurological and psychiatric disorders, in adults and in children. Frequently, CPTs also use a continuous vigilance task, in order to obtain quantitative information about the individual’s ability to sustain attention in time. From its creation, the CPT paradigm has been used with many variants of its task component. Greenberg and Walkman (1993) found up to 100 different versions of CPT in use. Historically, when Rosvold and his collaborators introduced the test, they had the goal of measuring correct answers provided by the subject as an indicator of selective attention. With subsequent experimentation, other measures, such as processing speed, impulsivity, inattention, and sustained attention, divided or alternate, have been included.
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Spacagna Rose Line, de Fouquet Chantal, and Russo Giacomo. "Interpretation of CPTU Tests with Statistical and Geostatistical Methods." In Geotechnical Safety and Risk V. IOS Press, 2015. https://doi.org/10.3233/978-1-61499-580-7-910.
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In the paper statistical methods for the interpretation of CPT data for the definition of subsoil stratigraphy have been applied to a subsoil CPTU data set of the Italian Center of Aerospatial Research (CIRA) in Capua (Italy). Results obtained by following the method proposed by Wickremesinghe and Campanella (1991) have been compared with those obtained by a geostatistical method recently proposed by Spacagna (2014), based on the spatial variability analysis of CPTU data. The latter results showed a more detailed definition of the transitions between different subsoil layers along the investigated vertical axes.
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Spacagna Rose Line, Fouquet Chantal de, and Russo Giacomo. "Interpretation of CPTU Tests with Statistical and Geostatistical Methods." In Geotechnical Safety and Risk V. IOS Press, 2015. https://doi.org/10.3233/978-1-61499-580-7-892.
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In the paper statistical methods for the interpretation of CPT data for the definition of subsoil stratigraphy have been applied to a subsoil CPTU data set of the Italian Center of Aerospatial Research (CIRA) in Capua (Italy). Results obtained by following the method proposed by Wickremesinghe and Campanella (1991) have been compared with those obtained by a geostatistical method recently proposed by Spacagna (2014), based on the spatial variability analysis of CPTU data. The latter results showed a more detailed definition of the transitions between different subsoil layers along the investigated vertical axes.
Conference papers on the topic "CPTX"
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Mathiesen, Troels, Torben S. Nielsen, Jan Elkjaer Frantsen, John Kold, and Anne R. Boye-Moeller. "Influence of Various Surface Conditions on Pitting Corrosion Resistance of Stainless Steel Tubes Type EN 1.4404." In CORROSION 2006. NACE International, 2006. https://doi.org/10.5006/c2006-06095.
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Abstract The pitting resistance of pickled, ground and electropolished surfaces of EN 1.4404 (AISI 316L) tubes has been tested using cyclic polarization and ASTM G150 for determination of the pitting potential and CPT, respectively. The materials were tested in chloride-containing solutions with 0.05 to 5.0% Cl-. Crevice corrosion was avoided using a flushed port cell with a specially cast gasket. Ground finish having low surface roughness shows no improvement over the coarse pickled finish, while electropolished finish provides considerably higher resistance but at the same time scattered results. The two testing techniques give almost identical CPTs that show only little dependence on chloride concentration. The variation in pitting resistance has been correlated to the surface morphology of the different surface conditions.
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Lu, Q., V. Kumar, and MF Gittos. "Effect of Iron Content on Localised Corrosion Resistance of Ni-Cr-Mo Alloy Weld Overlays in Chloride Ion-containing Environments." In CORROSION 2016. NACE International, 2016. https://doi.org/10.5006/c2016-07630.
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Abstract Corrosion tests were carried out to determine the effect of iron content on localised corrosion resistance of Ni-Cr-Mo alloy weld overlays (e.g. Alloy 625) in chloride ion-containing environments. A range of iron contents (i.e. 5 – 50%) were examined using coupons extracted from weld overlays deposited on a low alloy steel. The iron content range was achieved by changing the welding parameters and the weld metals were deposited by gas tungsten arc/tungsten inert gas (GTA/TIG) and gas metal arc/metal inert gas (GMA/MIG) welding processes. The electrochemical behaviour of the overlays was determined in acidified 10%w/v NaCl solution at 25°C, using potentiodynamic polarisation curve measurements. Critical pitting temperatures (CPTs) and critical crevice temperatures (CCTs) were determined using standard test methods: ASTM G150 (CPT) and ASTM G48 Methods C (CPT) and D (CCT). Pitting and crevice corrosion tests were carried out in aerated artificial seawater, over a range of temperatures (from 25 to 70°C), and also in 25%w/v NaCl solution containing H2S/CO2 at 177°C and 53 bara. The results showed that localised corrosion resistance of the weld overlays was very similar in the range of iron content between 5 and 15%, in the environments tested, and the corrosion resistance was reduced, significantly, at iron contents greater than 30%.
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De-Abreu, Yolanda, Jason Helander, Heider A. Suarez, David Manko, and Jeffery Caleb Clark. "Pitting Resistance Evaluation of Stainless Steel Alloys in Presence of Neat Production Chemicals by Using Accelerated Electrochemical Tests." In CORROSION 2012. NACE International, 2012. https://doi.org/10.5006/c2012-01703.
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Abstract This paper proposes a novel approach to evaluate pitting resistance of austenitic and super duplex stainless steel in contact with typical corrosion inhibitors used in the oil and gas industry. In this study, accelerated electrochemical tests are used instead of conventional immersion tests to determine the compatibility of neat chemicals with different metallurgies. A modified version of the standard ASTM G611 and G1502 ASTM tests are used. Two neat corrosion inhibitors instead of the standard 1M NaCl solution were used as electrolytes and the ASTM G611 and ASTM G1502 electrochemical tests were run in order to find a correlation with actual operating conditions. Critical Pitting Temperature (CPT) of about 85°C and 76°C were obtained for SS304 in presence of Inhibitor A and Inhibitor B, respectively. CPTs greater than 80°C were reported for SS316L, SS317L, and SDSS2507 stainless steel materials immersed in both inhibitors A and B. Traditional immersion test may not reveal the susceptibility to pitting corrosion of a chemical in contact with a determined metallurgy.3 Alternatively the use of modified accelerated electrochemical tests have been demonstrated to be a quick and conservative screening tool when evaluating compatibility of neat chemicals with typical field metallurgies at actual field operating conditions.
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Mori, G. "User’S View of Pitting Corrosion." In CORROSION 2004. NACE International, 2004. https://doi.org/10.5006/c2004-04304.
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Abstract Pitting resistance equivalent number (PREN or PRE) has been introduced by suppliers as a tool for comparing stainless steels for their relative resistance to pitting. The user of stainless steels has only a very limited knowledge for PREN. Important questions for users are: “Which steel quality is necessary to be applied in a given environment?”, “Up to which temperature can a given stainless steel be applied in a certain environment?” or “Can the plant be operated with an increased chloride concentration up to … ppm?. To answer this questions based on literature data two formulas are proposed. The first is based on a purely linear approach and is limited therefore to chloride concentrations of 500 ppm and higher. The second formula uses a mixed hyperbolic and linear relation for the parameters PREN, chloride concentration and pH. Practical electrochemical measurements have been carried out to supply additional data for validation of the equation. Limitations and presumtions of the presented formula are discussed. It results in highly accurate critical pitting temperatures (CPTs) when using steels below a PREN of 30. Higher PRENs yields a conservative CPT. Influence of more parameters such as inhibition or acceleration by presence of additional ions other than Cl- and H+ in the solution, purity and amount of segregates of the alloys as well as effect of potential should be included in further research work to obtain a better predictive model.
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Arnvig, Poul-Erik, and Anne Dorthe Bisgård. "Determining the Potential Independent Critical Pitting Temperature (CPT) by a Potentiostatic Method Using the Avesta Cell." In CORROSION 1996. NACE International, 1996. https://doi.org/10.5006/c1996-96437.
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Abstract The development of a potentiostatic method for determining the potential independent Critical Pitting Temperature (CPT) using the Avesta Cell is presented. The new potentiostatic method has been used to determine the CPT for austenitic stainless steels. The precision of the potentiostatic method of approximately ± 2 °C is close to that of the traditional potentiodynamic method. The time required to determine a CPT is much shorter than when using the potentiodynamic method. A CPT is obtained within 1.5 to 3 hours for each specimen. The influence of various experimental parameters such as electrochemical potential, evaluation criteria for the CPT, test area, stabilization time prior to polarization and inert gas purging is described. The lack of sensitivity towards many of these parameters as well as the high reproducibility obtained is associated with fundamentals of the pitting process. It is argued that the potential independent CPT characterizes the stable propagating pitting event as opposed to the potential dependent CPT or pitting potentials, which to a larger extent are affected by the nucleation part of the pitting process.
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Garfias-Mesias, L. F., and S. R. Taylor. "In-situ CPT of Duplex Stainless Steels in Artificial Seawater Using ECN." In CORROSION 2017. NACE International, 2017. https://doi.org/10.5006/c2017-09312.
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Abstract This paper describes a novel methodology to measure the Critical Pitting Temperature (CPT) of a Duplex Stainless Steels (DSS) in artificial seawater based on the Electrochemical Noise (ECN) technique. The work presented here shows, for the first time, simultaneous in-situ micro-visualization and CPT of two 25Cr Duplex Stainless Steel (DSS) microelectrodes with the same composition and heat treatment while immersed in artificial seawater. A real time video of the surface, the natural current and potential between the two microelectrodes was recorded while the temperature was slowly increased. No potential bias was applied to either of the two microelectrodes. This methodology allowed the observation of metastable pitting below the CPT on both electrodes followed by stable pitting above the CPT of one of the microelectrodes. The CPT obtained using this methodology is in good agreement with the CPT of the same alloy which was obtained using the Zero Resistance Ammeter in other solutions including ferric chloride and using anodic polarization at different temperatures in 0.6 M NaCl solution.
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Garfias-Mesias, L. F., and S. R. Taylor. "In-situ Pitting of UNS S32550 Duplex Stainless Steel in Artificial Seawater below and above the Critical Pitting Temperature." In CORROSION 2016. NACE International, 2016. https://doi.org/10.5006/c2016-07837.
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Abstract This paper demonstrates a novel methodology that can be used to determine the factors that contribute to the initiation of pitting corrosion of Corrosion Resistant Alloys (CRAs) in aggressive environments above the Critical Pitting Temperature (CPT). The work presented here shows, for the first time, simultaneous in-situ micro-visualization and anodic polarizations of two microelectrodes made of UNS S32550 Duplex Stainless Steel (DSS) while immersed in artificial seawater. A real time video of the surface of the two electrodes was recorded while anodic polarizations were made at different temperatures below and above the CPT. This methodology allowed the observation of metastable pitting below the CPT of the alloy and stable pitting above the CPT of the 25 Cr DSS.
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Cash, Peter, John Bollettiero, Robert Connors, et al. "Ruggedized Rubidium CPT Clock Platform." In 2024 European Frequency and Time Forum (EFTF). IEEE, 2024. http://dx.doi.org/10.1109/eftf61992.2024.10722381.
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Lehnert, R. "Conceptual Basics of CPT Violation." In International Conference on Exotic Atoms and Related Topics and Conference on Low Energy Antiprotons. Sissa Medialab, 2025. https://doi.org/10.22323/1.480.0018.
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He, Wenle, Leandro Finzetto, Katarina Persson, and Per Olsson-Artberger. "UNS N08029 and UNS N08825 Tubes for Chemical Injections." In CORROSION 2019. NACE International, 2019. https://doi.org/10.5006/c2019-13162.
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Absrract Pitting corrosion resistance by critical pitting temperature (CPT) has been determined per ASTM G150 on the full-size control line & chemical line specimens of UNS N08029 and UNS N08825 in 1M NaCl solution. With outer- and inner tube surfaces in existing delivery conditions, the full-size tube sections of UNS N08029 showed similar CPT obtained from specimen coupons of cold worked UNS N08029 OCTG material. The CPT was 70°C for UNS N08029 and 30°C ~ 45°C for UNS N08825, which was mainly dependent on pitting resistant equivalent (PRE) of the materials. Effect of chloride concentration and pH on the CPT has also been studied however no significant effects have been observed for UNS N08029 and UNS N08825 in the tested conditions. UNS N08029 of high PRE, showed higher CPT compared to UNS N08825 in 3~15 wt% chloride concentrations. UNS N08029 and UNS N08825 belong to the same categories 4a and 4c type nickel-based alloys defined by ISO15156-3 for down-hole applications. Good resistance to stress corrosion cracking (SCC) has been found in literature for the OCTG grade of these alloys. Of similar Ni+2Mo+0.5Cr content and high CPT in chloride solutions observed in this study, UNS N08029 would be recommended as a cost-efficient material for control line and chemical injection line applications when the SCC resistance is confirmed for the annealed tube product.
Reports on the topic "CPTX"
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Macedo, Jorge, Paul Mayne, Sheng Dai, et al. Cone Penetration Testing for Illinois Subsurface Characterization and Geotechnical Design. Illinois Center for Transportation, 2024. http://dx.doi.org/10.36501/0197-9191/24-013.
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This project sets the stage for implementing a cone penetration testing (CPT) practice in the state of Illinois, providing recommendations for using and interpreting CPT soundings in subsurface investigations. This study also contributes to modernizing Illinois Department of Transportation (IDOT) policy to current CPT-related practices adopted in other departments of transportation, which is consistent with recommendations from the Federal Highway Administration. Toward the goals of this project, CPT soundings across the nine districts of the state of Illinois have been conducted, and available CPT data at IDOT have been evaluated. The generated data have been uniformly processed, generating a database of 156 CPTs distributed across the nine districts. The database also includes shear wave velocity profiles at 28 locations and pore pressure dissipation tests at 45 locations. In addition, information (editable and non-editable) provided by IDOT has been carefully examined. The provided information consisted of boreholes with standard penetration test (SPT) data and laboratory tests on collected Shelby tubes. This information has been used to develop SPT-CPT correlations that can be applied in the state of Illinois and to provide examples of interpreting seismic piezocone test (SCPTu) data in the context of laboratory testing. Due to the several independent, fast, and reliable measurements that can be conducted in a CPT sounding and the fact that they can be done cost-effectively, CPT soundings are increasingly being preferred for in situ testing, and their adoption at IDOT is a positive step forward and consistent with the best practices at other U.S. departments of transportation.
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Niazi, Fawad. CPT-Based Geotechnical Design Manual, Volume 1: CPT Interpretation—Estimation of Soil Properties. Purdue University, 2022. http://dx.doi.org/10.5703/1288284317346.
Full textAbstract:
This manual provides guidance on how to use the cone penetration test (CPT) for site investigation and foundation design. The manual has been organized into three volumes. Volume 1 covers the execution of CPT-based site investigations and presents a comprehensive literature review of CPT-based soil behavior type (SBT) charts and estimation of soil variables from CPT results. Volume 2 covers the methods and equations needed for CPT data interpretation and foundation design in different soil types, while Volume 3 includes several example problems (based on instrumented case histories) with detailed, step-by-step calculations to demonstrate the application of the design methods. The methods included in the manual are current, reliable, and demonstrably the best available for Indiana geology based on extensive CPT research carried out during the past two decades. The design of shallow and pile foundations in the manual is based on the load and resistance factor design (LRFD) framework. The manual also indicates areas of low reliability and limited knowledge, which can be used as indicators for future research.
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Sakleshpur, Venkata A., Monica Prezzi, Rodrigo Salgado, and Mir Zaheer. CPT-Based Geotechnical Design Manual, Volume 2: CPT-Based Design of Foundations—Methods. Purdue University, 2022. http://dx.doi.org/10.5703/1288284317347.
Full textAbstract:
This manual provides guidance on how to use the cone penetration test (CPT) for site investigation and foundation design. The manual has been organized into three volumes. Volume 1 covers the execution of CPT-based site investigations and presents a comprehensive literature review of CPT-based soil behavior type (SBT) charts and estimation of soil variables from CPT results. Volume 2 covers the methods and equations needed for CPT data interpretation and foundation design in different soil types, while Volume 3 includes several example problems (based on instrumented case histories) with detailed, step-by-step calculations to demonstrate the application of the design methods. The methods included in the manual are current, reliable, and demonstrably the best available for Indiana geology based on extensive CPT research carried out during the past two decades. The design of shallow and pile foundations in the manual is based on the load and resistance factor design (LRFD) framework. The manual also indicates areas of low reliability and limited knowledge, which can be used as indicators for future research.
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Sakleshpur, Venkata A., Monica Prezzi, Rodrigo Salgado, and Mir Zaheer. CPT-Based Geotechnical Design Manual, Volume 3: CPT-Based Design of Foundations—Example Problems. Purdue University, 2022. http://dx.doi.org/10.5703/1288284317348.
Full textAbstract:
This manual provides guidance on how to use the cone penetration test (CPT) for site investigation and foundation design. The manual has been organized into three volumes. Volume 1 covers the execution of CPT-based site investigations and presents a comprehensive literature review of CPT-based soil behavior type (SBT) charts and estimation of soil variables from CPT results. Volume 2 covers the methods and equations needed for CPT data interpretation and foundation design in different soil types, while Volume 3 includes several example problems (based on instrumented case histories) with detailed, step-by-step calculations to demonstrate the application of the design methods. The methods included in the manual are current, reliable, and demonstrably the best available for Indiana geology based on extensive CPT research carried out during the past two decades. The design of shallow and pile foundations in the manual is based on the load and resistance factor design (LRFD) framework. The manual also indicates areas of low reliability and limited knowledge, which can be used as indicators for future research.
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Cassem, B. R. McGee Ranch CPT investigation. Office of Scientific and Technical Information (OSTI), 1993. http://dx.doi.org/10.2172/10193561.
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Yang, Songhoon. Test of CPT Invariance in B Factories. Office of Scientific and Technical Information (OSTI), 1999. http://dx.doi.org/10.2172/10005.
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Kim, Daehyeon, Younjin Shin, and Nayyar Siddiki. Geotechnical Design Based on CPT and PMT. Purdue University, 2010. http://dx.doi.org/10.5703/1288284314264.
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Karlsson, Magnus R. CPT Symmetry of Neutral Kaons: An Experimental Test. Office of Scientific and Technical Information (OSTI), 1990. http://dx.doi.org/10.2172/1427757.
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Morey, Rexford M., Susanne M. Conklin, P. E. Stephen P Farrington, and James D. Shinn II, P.E. TOMOGRAPHIC SITE CHARACTERIZATION USING CPT, ERT, AND GPR. Office of Scientific and Technical Information (OSTI), 1999. http://dx.doi.org/10.2172/773811.
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Rexford M. Morey. Tomographic Site Characterization Using CPT, ERT, and GPR. Office of Scientific and Technical Information (OSTI), 1997. http://dx.doi.org/10.2172/1672.
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