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Gustafson, Ellen, and Emelie Strömgren. "Cone Penetration Test - a comparative study of the equipment and the performance." Thesis, Linköpings universitet, Kommunikations- och transportsystem, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-121130.
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Inom geotekniken behövs ofta jordlagerföljden och jordens egenskaper bedömmas. För att göra detta används ofta sonderingsmetoden Cone Penetration Test (CPT), som används främst till att ge en preliminär bedömning av jordlagerföljden och en uppskattning av geotekniska egenskaper. CPT-sondering är en avancerad metod som ställer högre krav på både fältgeotekniker och handläggande geotekniker jämfört med andra metoder och är en metod där många faktorer påverkar resultatet. Detta examensarbete undersöker vilka faktorer som påverkar CPT-sondering med fokus på utrustning och handhavandet hos teknikkonsultföretaget WSP i Östergötland. Syftet med arbetet är att jämföra och utvärdera metod och resultat hos WSP för att se om det finns några skillnader i handhavandet och mellan de tre olika sonderna som är använda i studien. I studien utfördes 12 stycken CPT-sonderingar i samma område och dessa utfördes av samma fältgeotekniker, där häften av sonderingarna var utförda med förborrning och vattenfyllt sonderingshål och den andra hälften utförda med endast förborrning. Dessutom utfördes en skruvprovtagning i området. När sonderingarna var gjorda utvärderades resultaten i programvaran Conrad. Sonderingarna utfördes i ett område mellan Vånga och Göten, väster om Norrköping och området består främst av silt med lager av sand. Resultatet av studien visar att sond A har de jämnaste resultaten och orsaken till detta är troligtvis att denna sond är den som senast har kalibrerats. Efter sondering 2-C upptäcktes en skada på friktionshylsan för sond C, friktionshylsan byttes ut och trots detta ser resultatet för denna sond bra ut. Den första sonderingen gjord efter byte av friktionshylsan avviker dock i resultatet jämfört med de andra sonderingarna gjorda med sond C. Resultatet från sond B visar att denna sond uppnår lägre värde jämfört med de andra sonderna. En orsak till detta anses vara att denna sond är den sond som är kalibrerad med det tidigaste datumet. Slutsatsen i studien är att de faktorer som påverkar resultatet mest är kalibrering, att sonden är vätskemättad och att kontroller har utförts av sonden innan och efter sonderingen.
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Souza, Leandro Moreno de. "Software para análise e interpretação de resultados de ensaios CPT e CPTu." Universidade Federal de Viçosa, 2017. http://www.locus.ufv.br/handle/123456789/10843.
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Previous issue date: 2017-02-24<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>A busca por investigações geotécnicas precisas para o reconhecimento dos maciços de solo tornaram-se cada vez mais indispensáveis e ocupam um papel fundamental na Engenharia Civil, sendo que as investigações são realizadas em laboratório ou em campo. Um dos exemplos de ensaios de campo, o CPT – Cone Penetration Test, é constituído por um sistema de cravação semicontínua no solo de um conjunto de tubos e hastes de aço dotado de uma ponta cônica. Através deste procedimento, a estimativa e determinações da natureza, sequência e propriedades de engenharia das camadas subsuperficiais de solo podem ser realizadas. Considerando a falta de ferramentas computacionais que realizam a interpretação e analise do ensaio CPT e CPTu em língua portuguesa, esse trabalho visa suprir a carência de ferramentas computacionais para a análise e interpretação dos resultados do ensaio CPT e o procedimento para a construção da plataforma digital, denominado iCPT, foi utilizada a ferramenta Borland Delphi 7.0. Com os resultados obtidos dos ensaios CPT/CPTu, os mesmos foram comparados e confrontados com os resultados fornecidos pelos ensaios SPT, DMT e ensaios de laboratório realizados através de amostras e furos de sondagens, localizados no Campo Experimental de Engenharia Civil da Universidade Federal de Viçosa em Minas Gerais, em estudos previamente realizados por MINETTE et al. (1995), LOPES (1997), MONTEIRO (1999), ALMEIDA (2000) e DA SILVA (2000). Com os resultados encontrados através das comparações, constatou-se que: (i) para efeito de classificação do solo através do uso de ábacos de classificação, houve algumas camadas que apresentaram similaridade com outros métodos de campo ou de laboratório; (ii) quanto à determinação de propriedades geotécnicas através de correlações propostas, observou-se que: (a) o peso específico, teve uma proximidade dos valores daqueles aferidos em laboratório; (b) no caso de valores de OCR através de ensaios de laboratório para aqueles oferecidos pelo iCPT, há uma diferença entre os mesmos; e (c) quanto à determinação do ângulo de atrito os valores se mostraram próximos em comparação aos ensaios de compressibilidade; (iii) com relação a parte gráfica e visual, os resultados do iCPT apresentaram um ambiente agradável e eficiente.<br>The search for geotechnical investigations for the recognition of the massive form of soil became increasingly more vital and play a role based on Civil Engineering, being that the investigations are carried out in the laboratory or in the field. One of the examples of field trials, the CPT Cone Penetration Test, it is comprised of a system of inserting semi in the soil of a set of tubes and steel rods with a conical tip. Through this procedure, the estimation and determination of the nature, sequence and properties of engineering of subsurface layers of soil can be carried out. Considering the lack of computational tools that perform the interpretation and analysis of the test CPT and CPTu in portuguese, this study aims to overcome the lack of computational tools for the analysis and interpretation of the results of the test CPT and the procedure for the construction of the digital platform, called iCPT, was used the tool Borland Delphi 7.0. With the result obtained for testing CPT/CPTu, they were compared and confronted with the results provided by the tests SPT, DMT and laboratory tests performed through samples and drilling of probes, located in the Experimental Field of Civil Engineering at the Federal University of Viçosa in Minas Gerais, in studies previously conducted by MINETTE et al. (1995), Lopes (1997), Monteiro (1999), Almeida (2000) and Silva (2000). With the results found by the comparisons, it was found that: (i) for the purpose of soil classification through the use of charts of classification, there were some layers that showed similarity with other methods of field or laboratory; (ii) for determination of geotechnical properties through correlations proposals, it was observed that: (a) the specific weight, had a closeness of the values of those measured in the laboratory; (b) in the case of values of OCR through laboratory testing to those offered by the iCPT, there is a difference between them; and (c) regarding the determination of the angle of friction values are shown next in comparison to the tests of compressibility; (iii) with respect to the graphics and visual, the results of the iCPT presented a pleasant and efficient.
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Souza, Jeffson Murilo Santos de. "A influência da compacidade das areias nas correlações entre os ensaios de cone e o SPT." Universidade do Estado do Rio de Janeiro, 2009. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=1103.
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Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro<br>Correlations between the results from cone and SPT in sands are established in the present research for different sand densities. Such proposition is based on the experience obtained with the use of piezocone whose penetration in sands occurs commonly in drained condition. The SPT penetration, on the other hand, is much faster, occurring in a partially drained condition. The results confirm distinct correlations for different sand densities. The qc/NSPT ratio of 0,6MPa for sands, obtained from Danziger and Velloso (1986, 1995), for the whole data, is consistent with the value obtained in the present research if no distinction of density is made. If distinct density range is considered, the qc/NSPT ratio was found to be 1,1; 0,8; 0,6 and 0,5MPa, respectively for very loose, loose, medium and dense sands. Such results have repercussion on foundation design, as long as the most common methods applied in design make use of correlations between the CPT and SPT results. While the traditional correlations depend only on soil granulometry, the results presented in this research show that the relative density is of fundamental importance and must be also considered. In relation to the friction ratio, no tendency of variation with the relative density of sand has been observed, as expected, as long as both fs and qc are obtained from the cone. The results obtained with Palacios
(1977) data, with liner removal, and also the comparison between the resistance mobilized during the SPT sampler penetration evaluated by Schmertmann (1979) and Aoki et al. (2004) show that sampler plugging in sand probably does not occur.<br>Nesta pesquisa são estabelecidas correlações entre os resultados de ensaios de cone (CPT) e de SPT em areias, para diferentes faixas de compacidade. A proposta se fundamenta em experiência com o ensaio de piezocone, que ocorre quase sempre nas areias em condições drenadas. A realização do SPT se dá a maiores velocidades, em condição parcialmente drenada. Os resultados confirmam diferentes correlações para diferentes compacidades. Verificou-se que o valor 0,6MPa da relação qc/NSPT para areias, indicado por Danziger e Velloso (1986,1995), para os dados globais, é consistente com a média da faixa indicada nesta dissertação. Considerando-se as diferentes faixas de compacidade os valores encontrados de qc/NSPT foram de 1,1; 0,8; 0,6; 0,5MPa, respectivamente para areias fofas, pouco compactas, medianamente compactas e compactas. Tais resultados têm repercussão no projeto de fundações, em que métodos de projeto utilizam correlações entre os resultados de SPT e CPT. Enquanto nas correlações tradicionais os valores de qc/NSPT são função apenas da granulometria, os resultados apresentados mostram que a compacidade relativa tem importância fundamental, devendo ser também considerada. Em relação à razão de atrito, não se observou tendência de variação com a compacidade, conforme esperado, pois tanto fs como qc são obtidos do cone. Os resultados obtidos com os dados de Palacios (1977), com a remoção do liner, bem como a comparação entre os valores da força resistente à penetração do amostrador, a partir da interpretação de Schmertmann (1979) e Aoki et al. (2004), sinalizam para o não embuchamento do amostrador quando da sua penetração em areias.
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Rydman, Oskar. "Integration of Borehole, Ground, andAirborne Data to Improve Identificationof Areas With Quick Clays in Sweden." Thesis, Uppsala universitet, Geofysik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-445689.
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The main focus of the project was the comparison of results from a new towed transientelectromagnetic (tTEM) data set with existing data including airborne transient EM(ATEM), radio magnetotellurics (RMT), cone penetration test with resistivity (CPT-R),geotechnical interpretations and geological observations in a quick clay landslide site atFråstad close to Lilla Edet in south-west Sweden. The tTEM data set was processedand inverted twice in the software Aarhus workbench using different inversion constraintsand settings. The resulting resistivity models where compared with previous geophysicalmodels based on both ATEM and RMT as well as geotechnical information in the form ofborehole logs and CPTR measurements. The results compared well with all other modelsand predicts resistivities in the range of 10−40Ωmin areas of interpreted to hold quickclay by geotechnical methods. As a ground geophysical method the tTEM method is fastand cost-effective, particularly in more open areas with little topographical variations. Inthe example presented in this study tTEM measurements are deemed an effective andaccurate tool to map areas of potential quick clay using the inverted resistivity models incombination with other geological and geotechnical data.<br>Huvudsyftet med detta projekt är en sammanställning och jämförelse mellan resistivitetsmod-eller från ett nytt markburet TEM data set (tTEM) och tidigare insamlade luftburnaTEM data (ATEM), RMT (radiomagnetotellurik) samt detaljerade resistivitetsmätningari borrhål (CPT-R). Mätområdet ligger i Fråstad vid Göta älv i Lilla Edets kommun isydvästra Sverige. Tidigare undersökningar har visat att området innehåller kvickleraoch där förekommer även skredärr från tidigare kvickleraskred. tTEM datan bearbe-tades,filtrerades och inverterades med hjälp av mjukvaran Aarhus workspace med tvåolika set av begränsningar och inställningar. De resulterande resistivitetsmodellerna jäm-fördes med tidigare geofysiska metoder i ATEM och RMT samt med geoteknisk infor-mation i formen av borrhålsloggar samt CPTR mätningar. Resultatet visar en mycketgod korrelation mellan resistivitetsmodellerna från de olika dataseten. De modelleraderesistiviteterna var 10−40Ωm för de områden som med geotekniska metoder identifieratssom kvickleraområden. Som en markbunden metod är tTEM snabb och kostnadseffektiv,särskilt vid användning i öppna ytor med liten topografisk variation. I exemplen somvisas i denna studie dras slutsatsen att tTEM är ett effektivt och noggrant verktyg föratt hitta områden som potentiellt kan hålla kvickleror. Där kan sedan de resulteranderesistivitetsmodellerna användas tillsammans med annan geoteknisk och geologisk dataför att effektivt kartlägga dessa kvicklersområden.
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Kardan, Caesar. "Quality of CPTU : Analyses and comparison of data from commercial actors in Stockholm/Mälardalen." Thesis, KTH, Jord- och bergmekanik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-161222.
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CPTU is one of the most sophisticated geotechnical investigation methods. However, there is a large amount of uncertainties related to this method. The uncertainties depend on different types of factors, for instance lack of accuracy in performance and equipment. The objective of this master thesis is to compare the CPTU-results from a number of commercial actors in Stockholm/Mälardalen in order to analyze these results with respect to the current standards and guidelines. The comparison was made in order to highlight the difference in results which may appear due to different equipment, performance of the operator and evaluation method. Based on this, an invite was sent to the commercial actors in Stockholm/Mälardalen, resulting in the participation of five different commercial actors in this investigation. Execution in the field was conducted over a six week period. During this time 26 CPTU were performed in total in a small area in Hagby, Stockholm, by these different actors. Once the data was collected from all of the actors, the results were evaluated with the aid of the computer softwares Conrad and Excel. The main conclusions from this study are: Not one of the performed CPTU in this master thesis fulfills the requirements for CPT class 1 according to the European standards. The quality of the education of operators should be improved and geotechnical engineers and the clients need to be more familiar with CPTU. The evaluated results from different commercial actors differ, and this can depend on the choice of equipment and performance of the operator during penetration, but it can also depend on systematic errors in the cone penetrometers<br>CPTU-sonderingar är en av de mest sofistikerade undersökningsmetoderna för geoteknisk analys och bedömning. Det finns emellertid en hög grad av osäkerhet i denna metod. Osäkerheten beror på olika typer av faktorer, bland annat brist på noggrannhet i handhavande och utrustning. Syftet med detta examensarbete är att jämföra CPTU-resultat från de kommersiella aktörerna i Stockholm/Mälardalen för att senare analysera dessa resultat i förhållande till gällande ramverk och riktlinjer. Jämförelsen gjordes med avsikt att lyfta fram skillnaderna i resultat som kan uppstå på grund av olika utrustning, handhavande och utvärderingsmetod. Baserat på detta skickades en inbjudan till de kommersiella aktörerna i Stockholm/Mälardalen, vilket ledde till att fem olika kommersiella aktörer deltog i undersökningen. Utförande i fält genomfördes under en period på sex veckor. Under denna tid utfördes totalt 26 sonderingar i ett avgränsat område i Hagby, Stockholm, av dessa olika aktörer. När all data samlats in från alla aktörer utvärderades resultaten med hjälp av mjukvarorna Conrad och Excel. De viktigaste slutsatserna i denna studie är: Ingen utav de utförda CPTU-sonderingarna uppfyller kraven för CPT klass 1 enligt den europeiska standarden. Kvaliteten på utbildning av fältgeotekniker bör förbättras och geotekniska ingenjörer och även beställare bör bli mer bekanta med CPT. De utvärderade resultaten från de olika aktörerna skiljer sig åt, och detta kan bero på valet av utrustning och fältgeoteknikerns prestation vid sondering men det kan också bero på systematiska fel i de använda sonderna.
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Pujol, Vidal Maria Magdalena. "Relació estructura-funció de les proteïnes CPT1." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/83864.
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L’enzim Carnitina palmitoïltransferasa 1 (CPT1) permet l’entrada dels àcids grassos de cadena llarga a la matriu mitocondrial per tal de ser degradats i utilitzats així com a substrat energètic. El malonil-CoA, primer intermediari en la síntesi d’àcids grassos, és un inhibidor al•lostèric de CPT1, fet que permet una regulació coordinada entre la síntesi i l’oxidació d’àcids grassos en un mateix teixit, evitant així que es donin ambdós processos alhora. Una inhibició específica de CPT1, doncs, és una bona aproximació farmacològica per al tractament de desordres metabòlics que impliquin acumulació d’àcids grassos i resistència a insulina, com la diabetis tipus 2 i l’obesitat.
La present tesi doctoral s’ha centrat en l’estudi de la regulació per malonil-CoA dels isotips hepàtic (CPT1A) i muscular (CPT1B) de CPT1, així com en l’estudi de l’isotip més recentment descrit de la proteïna d’expressió en cervell, CPT1C. Per tal d’aprofundir en l’estudi de determinants moleculars de CPT1 que marquen el seu grau d’inhibició per malonil-CoA, s’han realitzat construccions mutants i delecionades dels enzims CPT1A i CPT1B i s’han expressat en el llevat “Pichia pastoris”. Mitjançant l’anàlisi del paràmetre IC50, hem demostrat que la regió aminoterminal de l’enzim CPT1A de rata (residus 1-18) exerceix un efecte dominant sobre les posicions Glu590 i Met593 en determinar la sensibilitat a la inhibició per malonil-CoA. Paral•lament, s’han generat construccions amb la seqüència de l’enzim CPT1 de porc, que presenta una gran diferència en el seu comportament enzimàtic quan es compara amb l’enzim humà, tant l’isotip hepàtic com el muscular. En aquest treball s’ha identificat l’existència d’un determinant negatiu en la posició Glu17 que explica parcialment la menor sensibilitat d’aquest enzim a la inhibició pel malonil-CoA. A més a més, s’ha construït un model 3-D in silico de la CPT1B humana, que permet justificar observacions experimentals mostrades en aquest treball, tot i que no explica encara les diferències en el comportament cinètic entre els isotips hepàtics i musculars de la proteïna. CPT1C és l’isotip descrit més recentment, i encara avui se’n desconeix la seva funció, existeix controvèrsia respecte a la seva distribució subcel•lular i no se n’han descrit els mecanismes que en regulen l’expressió. Els resultats mostrats en aquest treball demostren que CPT1C és una proteïna sense activitat enzimàtica, independentment de la característica extensió C-terminal que presenta respecte els altres isotips. D’altra banda, el patró d’expressió observat del gen Cpt1c no és compatible amb el paper que se li ha atorgat sobre la regulació de la ingesta. A més a més, hem identificat l’expressió d’una isoforma soluble de CPT1C en cervell humà adult, que ofereix una eina útil per a l’obtenció d’un cristall de la regió C-terminal citosòlica de CPT1C.<br>STRUCTURE-FUNCTION RELATIONSHIP OF CPT1 PROTEINS
CPT1 (Carnitine palmitoyltransferase 1) enables the entry of long chain fatty acids into the mitochondrial matrix, in order to be degraded and used as energetic substrate. Malonyl-CoA, the first intermediate in the synthesis of fatty acids, is an allosteric inhibitor of CPT1. Through CPT1 inhibition, it establishes a coordinated regulation between fatty acid synthesis and oxidation, thus preventing that both pathways coexist at the same time. A specific inhibition of CPT1 is therefore a good approximation or the pharmacological treatment of metabolic disorders involving accumulation of fatty acids and nsulin resistance, such as type-2 diabetes and obesity.
This thesis has focused on the study of malonyl-CoA regulation of both CPT1A and CPT1B isotypes. In addition, we studied the more recently described isotype of the protein, CPT1C. To gain insight into the study of CPT1 molecular determinants of malonyl-CoA inhibition, mutants of both CPT1A and CPT1B enzymes were expressed in yeast Pichia pastoris. Analysis of the IC50 parameter, demonstrated that the aminoterminal region (residues 1-18) of the rat CPT1A enzyme has a dominant effect over Glu590 and Met593 positions in determining its sensitivity to malonyl-CoA inhibition. We also identified the existence of a negative determinant within the sequence of pig CPT1A (position Glu17), which partially explains the low sensitivity of this enzyme to malonyl-CoA inhibition. In addition, we designed an in silico 3-D model of human CPT1B, which still does not explain the kinetic differences between liver and muscle isotypes of the protein, but justifies some of our experimental data. CPT1C is the more recently described isotype of the protein. Its function still remains unknown, and controversy exists regarding its subcellular distribution and the mechanisms that regulate its expression. Here we show that CPT1C is a protein without enzymatic activity, regardless of its characteristic C-terminal extension, compared to the other isotypes. Moreover, the observed gene expression pattern is not compatible with its given role on the regulation of food intake. In addition, we identified the expression of a soluble isoform of CPT1C in human adult brain, providing a useful tool for obtaining a crystalline structure of the cytosolic C-terminal region of CPT1.
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Mjöberg, Mårten, and Axel Stenfors. "CPTu Configuration Impact on Evaluated Undrained Shear Strength." Thesis, KTH, Jord- och bergmekanik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-279465.
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This thesis evaluates the commonly used geotechnical probing method CPTu, on how different probe configurations impact the resulting evaluated undrained shear strength in soft clay deposits, in comparison to each other and laboratory methods. This is done by performing field investigations on Lindefältet, Södermanlands län, Sweden. Comparison is done on the two Swedish manufacturers of CPTu probes, by different calibration limits, filter types and whether overloading the probe over the calibration limit affects the evaluated undrained shear strength registered. The main conclusions are that one of the manufacturers’ probes registers deviating results in one configuration, that calibration limit has a noticable impact on the results, and that overloading on the probe and filter choice has negliable impact on the results.<br>I detta examensarbete utvärderas den vanligt förekommande geotekniska sonderingsmetoden CPTu, på hur olika konfigurationer av sonder påverkar den resulterande utvärderade odränerade skjuvhållfastheten i lösa leravlagringar, 9i jämförelse med varandra och med laboratoriemetoder. Detta är genomfört genom fältundersökningar på Lindefältet, Södermanlands län. Jämförelsen gjordes på de två svenska CPTu-tillverkarnas sonder. Detta är gjort med hänsyn till olika kalibreringar av konspetstryck, filtertyper, och huruvida sonden har varit överlastad påverkar den utvärderade skjuvhållfastheten som registreras. De huvudsakliga slutsatserna är att en av tillverkarnas sonder registerar udda värden i en konfiguration, att kalibreringar av konspetstryck har en märkbar påverkan på de resulterande värdena på utvärderade odränerade skjuvhållfastheten, samt att överlastning av sonder och val av filtertyp har liten till omärkbar påverkan på resultatet.
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Ozkahriman, Fatma. "Cpt Based Compressibilty Assessment Of Soils." Master's thesis, METU, 2004. http://etd.lib.metu.edu.tr/upload/12605144/index.pdf.
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One of the most critical problems geotechnical engineers face with is the determination of the amount of consolidation settlement that will occur at a site as a result of the construction of a structure. The compressibility behavior of the soil is an important parameter in determining the amount of consolidation settlement.
The goal of this study is to develop probabilistically based correlation between the compressibility behavior of soil and in-situ test data. Within the scope of this research effort, performed CPT tests and the recorded settlement case histories where consolidation settlements at the field under various surcharge loads were compiled from the Bursa East and West Waste Water Treatment Plant soil investigation projects. A database was composed of the results of 45 CPT and 57 settlement plate recordings. For the compilation of this database, a series of finite difference
software FLAC-3D analyses were carried out to calculate the change in stress distribution under the settlement plates. A maximum likelihood framework was used for the development of compressibility behavior of soils.
As a result of careful processing of available data, the cone tip resistance (qc), soil behavior type index (Ic) were selected as two important parameters effecting the value of the one-dimensional constraint modulus, M. The regression
analysis which uses the settlement values recorded at the site and those computed using the change in the stress distribution, the thickness of the sublayers and the
proposed one-dimensional constraint modulus were carried out to calculate the values of these model parameters. Two correlations based on the cone tip resistance and soil behavior type index were developed for the computation of the one-dimensional constraint modulus, M.
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Schimmel, Jörn [Verfasser]. "CPT Verletzung und chirale Gittereichtheorie / Jörn Schimmel." Aachen : Shaker, 2003. http://d-nb.info/1181601738/34.
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anderson, David L. "Studies in CPT violation and 331 models." W&M ScholarWorks, 2006. https://scholarworks.wm.edu/etd/1539623495.
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The Standard Model of particles and fields has been around for about 30 years, and has been remarkably successful. However, it is widely believed to be incomplete, and theorists have studied various extensions to the model. These extensions can take many forms. An example of this is the framework Colladay and Kostelecky have proposed for studying Lorentz and CPT violation in a natural extension of the Standard Model. We determined the first bounds on the parameters in the Higgs sector. The bounds on the CPT---even asymmetric coefficients arise from the one-loop contributions to the photon propagator, those from the CPT---even symmetric coefficients arise from the equivalent cmunu coefficients in the fermion sector, and those from the CPT odd coefficient arise from bounds on the vacuum expectation value of the Z-boson. It is also interesting to look at the gauge structure of the Standard Model, and determine new effects that may arise if it is altered. One way to do this is to extend the SU(3)c x SU(2) L x U(1)Y gauge group to SU(3)c x SU(3)L x U(1) X, or what is called a 331 model. We studied variants of these models which are characterized by each lepton generation having a different representation under the gauge group. Flavor-changing neutral currents in the lepton sector occur in these models. to satisfy constraints on mu → 3e decays, the Z' must be heavier than 2 to 40 TeV, depending on the model and assignments of the leptons. These models can result in very unusual Higgs decay modes. In most cases the mutau decay state is large (in one case, it is the dominant mode), and in one case, the phi → ss?» rate dominates. Finally, it is possible to combine these approaches. This is particularly tempting in the currently exciting field of neutrino phenomena, where a combination of the 331 model with CPT-violating terms provides the terms necessary to explain the LSND anomaly, as well as the atmospheric and solar neutrino data. We also find predictions for relationships between the neutrino masses.
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SCANAVINO, MARCELLO. "Perturbing critical phenomena: from CPT to Holography." Doctoral thesis, Università degli studi di Genova, 2020. http://hdl.handle.net/11567/1032321.
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In this thesis we analyze different aspects of conformal field theories, one of the most powerful tools to study the physics of critical phenomena. Even though many progresses have been made in the knowledge and comprehension of conformal field theories, where the strong constraints imposed by conformal symmetry make the system easier to solve, still much needs to be done when a perturbation is introduced. We describe two different approaches which can be useful to tackle this problem. In particular in Chapter 2, we carefully describe the basic properties of Conformal Perturbation Theory (CPT), a mathematical tool to study conformal systems perturbed by relevant operators. We also provide two examples of how it can be applied and we match our finding with numerical Monte Carlo simulations. In Chapter 3, we study a conformal and relativistic hydrodynamic system,also making use of the AdS/CFT (or holographic) correspondence. This powerful technique, introduced in the context of string theory, becomes extremely relevant when one needs to study strongly correlated systems. In this case indeed, standard perturbative approaches usually fail: the holographic duality can be thought as a valid and complementary approach to investigate these important systems.
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Hundal, Erlend. "CPTU med målt total sonderingsmotstand : Nye muligheter for å detektere kvikkleire?" Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for bygg, anlegg og transport, 2014. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-27230.
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De siste årene har det vært økt fokus på forebyggende tiltak mot kvikkleireskred. Her har det dukket opp flere studier på hvordan kvikkleire kan detekteres på en rasjonell og pålitelig måte. I den forbindelse er det ønskelig å utnytte også informasjon fra total sonderingsmotstand målt ved CPTU-sonderinger, for utledning av total stangfriksjon. Den totale stangfriksjonen utledes ved å trekke fra den målte spissmotstanden. Stangfriksjonen kan da relateres til omrørt skjærfasthet og dermed også vurdering av kvikkleireforekomster.En direkte tolkning fra kurvehelning har blitt utviklet i et tolkningsark, basert på tidligere studier. Direkte tolkning av kvikkleireforekomst fra total stangfriksjon kan føre til feiltolking. Det må derfor benyttes manuelle tolkningslinjer i tolkningsarket.Resistivitetsmålinger fra R-CPTU har sammen med andre relevante tolkninger fra CPTU blitt brukt for å skape et bredere bilde av tolkningen. Det er vurdert muligheter for tolkning av sensitivitet fra den total stangfriksjonen, samt sett etter sammenheng mellom total stangfriksjon og akkumulert hylsefriksjon.Vurderinger av sensitivitet fra total stangfriksjon ser ikke ut til å ha noen direkte sammenheng. Det er heller ikke funnet noen direkte sammenheng for total stangfriksjon og akkumulert hylsefriksjon.Det har vært et mål å kunne vurdere påliteligheten av de ulike tolkningsmetodene for kvikkleireforekomst. Generelt har de fleste metodene overestimert forekomsten. Tolkningsmetoden som ga best pålitelighet er spissmotstandstallet Nm.Tolkning av kvikkleireforekomst fra resistivitetsmålinger ga overestimering ved bruk av intervallet 10 – 100 &#937;m som definisjon for mulig kvikkleire.
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Holt, Jim, Ambreen Warsy, and Paula Wright. "Medical Decision Making: Guide to Improved CPT Coding." Digital Commons @ East Tennessee State University, 2010. https://dc.etsu.edu/etsu-works/6484.
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Background: The Current Procedural Terminology (CPT) coding system for office visits, which has been in use since 1995, has not been well studied, but it is generally agreed that the system contains much room for error. In fact, the available literature suggests that only slightly more than half of physicians will agree on the same CPT code for a given visit, and only 60% of professional coders will agree on the same code for a particular visit. In addition, the criteria used to assign a code are often related to the amount of written documentation. The goal of this study was to evaluate two novel methods to assess if the most appropriate CPT code is used: the level of medical decision making, or the sum of all problems mentioned by the patient during the visit.
Methods: The authors–a professional coder, a residency faculty member, and a PGY-3 family medicine resident–reviewed 351 randomly selected visit notes from two residency programs in the Northeast Tennessee region for the level of documentation, the level of medical decision making, and the total number of problems addressed. The authors assigned appropriate CPT codes at each of those three levels.
Results: Substantial undercoding occurred at each of the three levels. Approximately 33% of visits were undercoded based on the written documentation. Approximately 50% of the visits were undercoded based on the level of documented medical decision making. Approximately 80% of the visits were undercoded based on the total number of problems which the patient presented during the visit. Interrater agreement was fair, and similar to that noted in other coding studies.
Conclusions: Undercoding is not only common in a family medicine residency program but it also occurs at levels that would not be evident from a simple audit of the documentation on the visit note. Undercoding also occurs from not exploring problems mentioned by the patient and not documenting additional work that was performed. Family physicians may benefit from minor alterations in their documentation of office visit notes.
Key Points:
* All previous studies of CPT coding have audited the written encounter note. * Medical decision making (MDM) is the most appropriate basis for selecting the CPT code for an office visit, as long as the history or the physical exam documentation also support that level. * Using MDM to retrospectively audit office visit notes showed that 50% of visits were undercoded. A small amount of additional documentation would allow the higher code. * Addressing all patient-mentioned problems during the visit, although clearly more time-consuming, would allow a higher CPT code to be used for 80% of the audited visits.
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Subramaniam, Sivaraman. "Role of the Cpx pathway in Salmonella pathogenesis." Berlin mbv, 2009. http://d-nb.info/998073199/04.
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Lafuerza, Sara. "Aplicacions del CPTU en Geociències Marines: estudi de casos de la Mediterrània." Doctoral thesis, Universitat de Barcelona, 2009. http://hdl.handle.net/10803/1582.
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Aquesta Tesi Doctoral tracta de l'aplicació de l'assaig de penetració in situ (CPTU) en l'estudi de les propietats geotècniques i sedimentològiques del recobriment sedimentari a quatre ambients sedimentaris de la Conca Mediterrània: la plana deltaica del delta del Llobregat, la plataforma externa i el talús superior del Golf de Lleó i el talús balear del Canal d'Eivissa, a la Conca Mediterrània Occidental, i el ventall submarí del Nil, a la Conca Mediterrània Oriental.<br/><br/>Aquest estudi es basa principalment en perfils de CPTU, altres assajos in situ com el piezòmetre i les diagrafies de pous, análisis sedimentològiques de mostres de sediment, anàlisis geotècniques de laboratori i dades geofísiques. La disponibilitat de dades a partir d'aquest ampli ventall de tècniques ha estat possible mercès a la col∙laboració amb la indústria destinada a la caracterització geotècnica dels fons marins. Els perfils de CPTU obtinguts a les seqüències sedimentàries investigades han permès reconèixer el gran potencial que té aquesta tècnica en la identificació del tipus de sediment i les seves propietats geotècniques.<br/><br/>Els resultats obtinguts mostren que la resistència normalitzada i la ràtio de fricció proporcionades pels CPTU constitueixen paràmetres molt útils per al reconeixement de tendències granulomètriques. Més precisament, hom ha demostrat que la fricció constitueix un paràmetre molt útil en la detecció de variacions granulomètriques en seqüències formades per materials fins, com les del talús del Golf de Lleó. D'altra banda, els perfils de la seqüència deltaica del delta del Llobregat han mostrat que la resistència no corregida també pot ésser representativa d'alternances de materials fins i grollers.<br/><br/>Hom ha estimat l'estat de consolidació pels tres cassos d'estudi del talús continental tot i aplicant la relació empírica basada en la relació entre la ràtio de sobreconsolidació, l'esforç de preconsolidació i l'esforç vertical efectiu. Mercès a aquesta aproximació hem vist que sota el nivell de sobreconsolidació aparent que la majoria de seqüències sedimentàries marines presenten, els sediments que no han estat afectats per processos de desestabilització solen presentar sobrepressió. On hi ha paquets de materials esllavissats, com al ventall submarí del Nil, els perfils de CPTU han permès identificar el grau de sobreconsolidació dels nivells reemmotllats. Aquesta sobrepressió respon a les condicions sedimentàries i estructurals de cada indret.<br/><br/>Al Golf de Lleó, la sobrepressió està associada a nivells relativament més grollers i permeables en els que hom hi ha detectat la presència de gas. Es tracta de nivells condensats dipositats en períodes d'alt nivell eustàtic. Hom atribueix l'acumulació de gas en aquests nivells a la degradació de la matèria orgànica i/o a la migració ascendente de gas, com suggereix la presència d'un cràter d'escapament (<i>pockmark</i>) de grans dimensions a tocar del punt d'assaig. Hom associa la sobrepressió a episodis de disminució de la pressió hidrostàtica que causaren l'exsolució del gas acumulat principalment en aquests nivells condensats; exsolució que es produiria durant les fases de nivell eustàtic baix dels darrers 340 ka. En canvi, al talús balear del Canal d'Eivissa, hom associa la sobrepressió amb la presència de capes carregades de bombolles de gas, possiblement d'origen volcànic o hidrotermal.<br/><br/>Aparentment, aquest gas s'acumulà preferentment en un nivell més groller i amb menor resistència a la cisalla (nivell feble o <i>weak layer</i>), tal i com ho indiquen el perfil corresponent i valors de sensitivitat molt elevats. Hom considera que aquests dos factors precondicionants (acumulació de gas i nivell feble) expliquen el desencadenament de l'esllavissament d'Ana, i el fet particular que allà on s'ha trobat erosió no hi ha sobrepressió, la qual cosa indicaria que la sobrepressió es dissipà per l'erosió associada a l'esllavissament.<br><i>The present PHD Thesis deals with the application of the in situ cone penetration test (CPTU) in the study of the physical and geotechnical properties of the sediment record at four sedimentary environments of the Mediterranean Basin: the Llobregat delta plain, the outer shelf and the upper slope of the Gulf of Lion in the western basin, and the Nile deep sea fan, in the eastern basin.<br/><br/>This study is mainly focused on CPTU profiles, other in situ tests such as the piezometer and well logs, sedimentological analyses, laboratory geotechnical analyses and geophysical data. Data availability from such a wide range of tools is thanks to the collaboration with the industry focused on the seafloor geotechnical characterization. CPTU profiles acquired in the studied sedimentary sequences allowed recognizing the large potential of the CPTU in identifying sediment type and providing its geotechnical properties. Results obtained show that CPTU derived normalised resistance and friction ratio are the most reliable parameters when interpreting grain size trends.<br/><br/>Particularly, we demonstrate that friction constitutes a promising parameter when dealing with fine‐grained sedimentary successions, as we found in the upper slope of the Gulf of Lion. Moreover, CPTU profiles in the sedimentary successions of the Llobregat Delta show that CPTU direct resistance measures can be very useful when interpreting heterogeneous sediments, such as coarse levels within fine‐grained sedimentary sequences.<br/><br/>We have estimated the consolidation state for the three continental slope study cases by applying the empirical approximation which defined the overconsolidation ratio as the ratio between the preconsolidation pressure and the vertical effective stress. Thanks to this approximation we observe that the below the apparent overconsolidation that characterised marine sedimentary sequences the sediments that remain unaffected by instability processes are usually underconsolidated due to the existence of overpressure. Where slided materials occur, such as those we found in the Nile deep sea fan, CPTU profiles allowed identifying the overconsolidation ratio in the remoulded sediments. Overpressure is related to particular sedimentary and structural conditions of each study case. In the Gulf of Lion, overpressure is related to coarse‐grained levels where we identify gas. Such levels correspond to condensed layers that were deposited under high sea level conditions.<br/><br/>We associate the gas accumulation in these levels to the organic degradation and/or an upward gas seepage, as suggested by the existence of a close pockmark. We link the overpressure to hydrostatic pressure diminutions causing gas exsolution during prolonged periods of sea level lowering of the last 340 kyr. In contrast, at the Balearic slope of the Eivissa Channel, we link overpressure to gas charging likely of volcanic or hydrothermal origin. Apparently, the gas was preferentially accumulated in a coarser layer in which the shear strength is lower (weak layer), as suggested by the corresponding profile and high values of sensitivity. We consider both features (gas charging and weak layer) the preconditioning for the Ana slide, as well as the fact that where erosion is found no overpressure is identified, thus suggesting that overpressure was locally dissipated by the slide. </I>
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Sosnoski, Jonatas. "Interpretação de ensaios de CPTU e DMT em solos com permeabilidade intermediária." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/156352.
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A indústria mineradora do país sofre constantemente com problemas ambientais devido à qualidade e volume de rejeitos gerados durante o processo de extração do minério. Os volumes gerados demandam grandes áreas para armazenagem e consequentemente obras complexas de contenção dos rejeitos. A engenharia geotécnica busca entender o comportamento mecânico de depósitos destes rejeitos através do uso de ensaios tanto de campo como de laboratório. Para isso utiliza ferramentas e procedimentos consagrados no meio técnico seguindo normas e procedimentos estabelecidos e consagrados mundialmente. No entendimento do comportamento mecânico dos solos argilosos, as análises são desenvolvidas em termos de tensões totais, já para os solos arenosos em termos de tensões efetivas. Todavia, para solos com granulometria intermediária, não se tem um consenso no que se refere à interpretação do comportamento mecânicos a partir de ensaios de campo Este trabalho apresenta resultados de ensaios de DMT e CPTU conduzidos em diferentes velocidades de penetração no intervalo de aproximadamente 1 e 57 mm/s, em depósito de rejeito de mineração, para avaliar tanto a influência da velocidade sobre as medidas do ensaio, quanto a transição das condições de fluxo ao redor do piezocone e durante a expansão da membrana do dilatômetro. Um equipamento simples e de baixo custo foi desenvolvido para monitorar a poropressão no centro da lâmina do DMT e dados são interpretados à luz das condições de drenagem impostas durante a execução do ensaio. Resultados indicam que as leituras e os valores de P0 e P1 são medidas de tensão total e por este motivo influenciadas pela magnitude da poropressão gerada durante a penetração da lâmina. Um novo Fator de Velocidade adimensional “Vt” é proposto para identificar possíveis efeitos de consolidação que ocorrem durante a penetração do piezocone e orientações são dadas para utilização de CPTU e DMT em solos de permeabilidade dentro do intervalo de 10-6 a 10-3 cm/s.<br>The mining industry of the country constantly suffers from environmental problems due to the quality and volume of waste generated during the mineral extraction process. Volumes generated require large areas for storage and consequently complex works of tailings. The geotechnical engineering seeks to understand the mechanical behavior of deposits of this waste by using assays well as laboratory and field. To this end tools and procedures laid down in the technical means following established rules and procedures consecrated worldwide. In the understanding of the mechanical behavior of clay soils, the analyzes are developed in terms of total stresses and for sandy soils in terms of effective stress. However, in soils with intermediate particle size, there is no consensus concerning the interpretation of the mechanical behavior from field trials. This paper presents the results of DMT and CPTU test conducted at different penetration rates in the range of about 1 to 57 mm / s in mining waste deposit to evaluate both the effect of speed on the measurements of the test, as the transition the flow conditions around the piezocone and during the expansion of the dilatometer membrane. A simple and inexpensive equipment has been developed to monitor the pore pressure in the center of the DMT blade and data are interpreted in the light of the imposed drainage conditions during the test. Results indicate that the readings that the P0 and P1 are total stress measurements and for this reason influenced by the magnitude of pore pressure generated during penetration of DMT blade. A new dimensionless Velocity Factor "Vt" is proposed to identify potential consolidation effects occurring during the penetration of piezocone and guidance is provided for use CPTU and DMT in soil permeability in the range 10-6 to 10-3 cm/s.
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Giri-Rachman, Ernawati Arifin. "The CPX two component regulatory system of V. cholerae." Thesis, University of Bristol, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274636.
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Carrasco, Martínez Juan Carlos. "Probing CPT breaking induced by quantum decoherence at DUNE." Master's thesis, Pontificia Universidad Católica del Perú, 2019. http://hdl.handle.net/20.500.12404/14341.
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We consider a beyond standard physics scenario, where neutrino is considered
as an open quantum system. In order to have that consideration we
use the Lindblad master equation, which introduce the quantum phenomena
called decoherence. In that context we explore one of the most exotic
of its consecuences, the CPT violation. We work in three
avor generation
case where making the SU(3) decomposition of the operators we encounter
that there exist fteen parameters in the decoherence matrix that explicitly
violate CPT. Regarding four of those parameteres we choose one case of
decoherence which will be tested at DUNE.<br>Trabajo de investigación
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Lledo, Veloso Cristóbal. "Stochastic thermodynamics for open quantum systems in the reapeated interaction scheme." Tesis, Universidad de Chile, 2017. http://repositorio.uchile.cl/handle/2250/147396.
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Magíster en Ciencias, Mención Física<br>Usamos la teoría de termodinámica estocástica para estudiar sistemas cuánticos cuya dinámica es descrita por mapas completamente positivos que preservan la traza (CPTP en inglés) debido a su interacción con un baño térmico. Estudiamos una clase más amplia de mapas con equilibrio, entre los cuales los mapas termales son solo un caso especial. En general, para mapas CPTP las cantidades termodinámicas tales como la producción de entropía y el trabajo realizado sobre el sistema dependen del estado combinado del sistema más baño. Mostramos que para mapas con equilibrio estas cantidades pueden ser escritas en términos de propiedades del sistema únicamente. Las relaciones que obtenemos son válidas para una intensidad de acoplamiento arbitraria entre el sistema y el baño termal. Estudiamos las fluctuaciones de las cantidades termodinámicas en el esquema de medición de dos puntos. Derivamos teoremas de fluctuación detallados para la producción de entropía y el trabajo y obtemos algunas simplificaciones para el caso de los mapas con equilibrio. Ilustramos nuestros resultados considerando un espín en un ciclo termodinámico y una cadena de espines 1/2 acopladas a un baño por uno de sus bordes. Conectamos además la condición de balance detallado cuántico para ecuaciones maestras de Lindblad con la propiedad de equilibrio de los mapas CPTP que, al iterarlos y en un límite particular, generan la ecuación maestra. Mostramos cómo obtener una concatenación de mapas que genera una ecuación de Lindblad forzada por los bordes dada apriori, como una forma de construir una termodinámica consistente para la dinámica de Lindblad.<br>Este trabajo ha sido parcialmente financiado por Conicyt a través de becas Magíster Nacional 2016, contrato N° 22161809
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CHATELAIN, EGGER FLORENCE. "Regulation hormonale et nutritionnelle de l'expression de la cpt i et de la cpt ii dans le foie de rat a la naissance." Paris 7, 1999. http://www.theses.fr/1999PA077045.
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Lors de contraintes physiologiques importantes (allaitement, jeune, diabete), le foie est capable de mettre en place une strategie d'epargne du glucose en utilisant preferentiellement les acides gras comme source energetique immediate. L'augmentation de l'oxydation hepatique des acides gras a chaine longue (agcl) a la naissance est due a l'apparition du systeme de transfert intramitochondrial des agcl. Ce systeme est compose de trois entites proteiques distinctes, la carnitine palmitoyltransferase i (cpt i) localisee dans la membrane mitochondriale externe, la carnitine acylcarnitine translocase situee dans la membrane mitochondriale interne, la cpt ii associee a la membrane mitochondriale interne. A la naissance, la concentration en arn messagers (arnm) codant la cpt i augmente suite a une stimulation de la transcription de ce gene. En revanche, la transcription du gene codant la cpt ii est deja active dans le foie ftal et reste inchangee a la naissance. Le but de ce travail etait de caracteriser le role des hormones pancreatiques et des acides gras dans la regulation de la transcription du gene codant la cpt i a la naissance. Dans des cultures primaires d'hepatocytes de ftus de rat qui presentent une faible activite cpt i, l'amp cyclique induit la transcription du gene codant la cpt i. Cette stimulation n'est maximale qu'en presence d'une carence relative ou absolue en insuline. Seuls les agcl induisent l'expression de la cpt i secondairement a une activation de la transcription de ce gene et a une stabilisation du transcrit. Cet effet des agcl est independant de leur degre d'insaturation, de leur metabolisme intramitochondrial, et n'est maximal qu'en presence d'une carence relative ou absolue en insuline. Grace a l'utilisation d'inhibiteurs de l'acyl-coa synthetase, nous avons montre que les acides gras libres plutot que les acyl-coa sont les metabolites intracellulaires responsables de l'effet genique des agcl. Les proliferateurs de peroxysomes sont egalement de puissants inducteurs du gene codant la cpt i. La similitude de leurs effets avec les agcl a conduit certains auteurs a suggerer l'existence d'un mecanisme commun lie a l'activation de recepteurs nucleaires, les peroxysome proliferator-activated receptor (ppar). Grace a l'utilisation d'inhibiteurs des voies de synthese de ligands potentiels des ppar et a l'etude de l'effet transcriptionnel des agcl et des proliferateurs de peroxysomes sur des constructions d'adn genomique de la cpt i, nos resultats suggerent que l'effet genique des agcl sur l'expression de la cpt i serait independant de l'activation des ppar.
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Pedro, Fernando Massora. "Eficácia da aplicação do ensaio CPTu no estudo dos solos para fins geotécnicos." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/14445.
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Mestrado em Geomateriais e Recursos Geológicos<br>A presente dissertação tem por objectivo principal apresentar avaliar a aplicação do ensaio CPTu, na sondagem de simples reconhecimento, visando uma melhor caracterização de perfis de solos para fins geotécnicos. Verificar a adequabilidade dos ensaios às condições do solo, por meio de proposições de classificação de comportamento de solos e da estimativa de parâmetros geotécnicos, assim como as possíveis correlações, teóricas e empíricas, entre os dados dos ensaios. Foram utilizados ensaios de cone, mecânico e eléctrico. As propostas para classificação dos tipos de solo, através do CPT, utilizadas indicaram duas camadas distintas a primeira de solos de comportamento arenosos a siltoarenosos e a segunda de solos de comportamento siltosos a siltoargilosos, em concordância com a classificação obtida em laboratório. As proposições utilizadas para estimativa de parâmetros geotécnicos tiveram que ser ajustadas para o solo do campo experimental. A correlação para a região em estudo foi usado o valor de Nk igual á 14. Na presente dissertação foram usadas quatro furações para o ensaio CPTu.
Os resultados da caracterização numérica com base nesses parâmetros, foram expostos de forma a verificar a eficácia deste ensaio na determinação dos parâmetros físicos e mecânicos associados as formações. O caso prático que suporta tal verificação, enquadra-se numa campanha de prospecção geológica-geotécnica realizada no âmbito de obras realizada sob direcção da Mota-ENGIL.<br>The present dissertation aims to evaluate the implementation of the present main essay CPTu in simple probing reconnaissance, aiming at a better characterization of soil profiles for geotechnical purposes. Check the suitability of the conditions of the soil, through the classification of propositions behavior of soils and estimation of geotechnical parameters, as well as the possible correlations, theoretical and empirical, between the test data. Cone tests were used, mechanical and electrical. The proposals for classification of soil types, through the CPT used indicated two distinct layers the first of sandy soil behavior to sandy-silt and the second of the silt behavior silt-clay soils, in accordance with the classification obtained in the laboratory. The propositions used to estimate of geotechnical parameters had to be adjusted to the soil of the experimental field. The correlation for the region under study was used the Nk value equal to 14. In this dissertation were used four hurricanes CPTu testing.
The results of numerical characterization based on these parameters, were exposed in order to verify the effectiveness of this test in the determination of physical and mechanical parameters associated with the formations. The case study which supports such verification, fits in a prospecting campaign-held as part of geotechnical works performed by the Directorate of Mota-ENGIL.
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GUGIATTI, ELENA. "A reversible carnitine palmitoyltransferase 1 (CPT1) inhibitor offsets chronic lymphocytic leukaemia cell proliferation." Doctoral thesis, Università degli studi di Genova, 2019. http://hdl.handle.net/11567/943017.
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Crucial for chronic lymphocytic leukaemia (CLL) development and progression are the iterative cycles of cell re-activation and proliferation that take place in lymphoid tissues. These iterative cycles are fundamental for the development and the progression of the disease.
Since cellular fatty acid (FA) import and oxidation (FAO) were recently reported to be upregulated in CLL, compared to normal B lymphocytes, we explored the in vitro effects of ST1326, a reversible inhibitor of carnitine-palmitoyl transferase 1A (CPT1A), on leukaemic cells subject to activating microenvironment-mimicking stimuli.
ST1326 induced dose-dependent mitochondrial dysfunction and cell death, which were remarkably higher in activated/proliferating than quiescent CLL cells. Drug sensitivity was observed irrespective of the presence of TP53 alterations or chromosomal abnormalities, which are known to cause chemoresistance in CLL patients.
The treatment of normal B lymphocytes with ST1326, at doses lethal to CLL cells, causes only a slight inhibition of cell activation/proliferation, indicating a modest cytostatic, not cytotoxic, effect.
ST1326 cytotoxicity in CLL was associated with decreased levels of intracellular Acetyl-CoA and down-regulation of signalling pathways that are crucial for leukaemic cell survival, activation and proliferation. In particular, environment-induced activation of STAT3 and STAT6 transcription factors, known to upregulate anti-apoptotic Bcl-2 family members Mcl-1 and Bcl-xL, was impaired by ST1326. As a consequence, drug combination experiments with the BH3-mimetic ABT-199/Venetoclax, whose effects are counteracted by Mcl-1/Bcl-xL and cell proliferation, showed strong ST1326-mediated potentiation of ABT-199 cytotoxicity in activated/proliferating CLL cells. We also observed that ST1326 showed a synergic effect with Fludarabine in activated/proliferating CLL cells.
The data indicate that CLL cells turning to an activated/proliferating state become more dependent on FAO and more sensitive to FAO-antagonists, and pave the way for ST1326 as an adjuvant tool in anti-CLL drug-combination regimens with drugs that lose efficacy on proliferating leukaemic cells.
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Mana, Capelli Sebastian C. "CopB from Archaeoglobus fulgidus: a thermophilic Cu2+ transporting CPx-ATPase." Digital WPI, 2003. https://digitalcommons.wpi.edu/etd-theses/426.
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In this work we present the first characterization of a Cu2+-transporting ATPase. The thermophilic bacteria Archaeoglobus fulgidus contains two genes, CopA and CopB, encoding for CPx-ATPases. CopB belongs to the subgroup IB-4 of the CPX-ATPases. These enzymes are characterized by a CPH motif in the 6th transmembrane domain and a His-rich N-terminus metal binding domain (MBD). CopB was heterologously expressed in E. coli. Membranes were prepared and used to measure activity. CopB was active at high temperature (75º C), high ionic strength and pH 5.7. The enzyme was activated by Cu2+, and in to a lesser extent by Ag+ and Cu+. CopB showed a Vmax = 5 µmol/mg/h and a high apparent affinity (K1/2 = 0.28 ± 0.09 μM) for Cu2+. Uptake of 64Cu2+ into everted vesicles was also measured in order to show that Cu2+ is not only activating the enzyme but being transported. Compared with CopB-WT, CopB-T (lacking the N-terminus MBD) did not show any difference in its activation by the different metal ions, demonstrating that the cytoplasmic MBD has no role in the metal selectivity. CopB-T also showed a 40 % decrease in the ATPase activity. CopB-WT and CopB-T presented similar levels of phosphorylation. However, CopB-T exhibited a reduced rate of dephosphorylation (slower transition from the E2P to the E2 conformation). These observations suggest a regulatory role for the cytoplasmic MBD.
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Paula, Lee Taylor de Moura. "Manifestação do ator: formação no Centro de Pesquisa Teatral (CPT)." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/27/27155/tde-28012015-110047/.
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A presente pesquisa, pautada por quase dez anos de constante aprendizado e prática artística no Centro de Pesquisa Teatral (CPT), aborda a Arte do ator pela perspectiva da prática formativa desenvolvida e aplicada por Antunes Filho. O estudo pretende refletir sobre a experiência proposta na formação dos atores no CPT e organizar o conceito de Manifestação elaborado pelo diretor. A dissertação analisa a origem da metodologia e contempla a investigação da recente prática formativa coordenada por Antunes, somando-se aos escassos, porém importantes, estudos sobre a trajetória do diretor, diferenciando-se desses por articular na análise do objeto de pesquisa a experiência cênica e a prática didática do pesquisador no contexto do CPT<br>This study, based on nearly ten years of constant learning and artistic practice at the Center of Theatre Research (CPT), discusses the Art of the actor through the perspective of formative practice developed and applied by Antunes Filho. The study aims to reflect about the experience proposed on the actor\'s training within the CPT and to organize the concept of Manifestation, created by the director. The dissertation examines the methodology\'s origin and contemplates the investigation of the recent formative practice leaded by Antunes, adding to the scarce, but important, studies on the director\'s trajectory, but differentiating from those by the articulation of the researcher\'s acting experience and teaching practice in the context of CPT.
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CARVALHO, Eduardo Santos. "Redução dimensional do setor CPT-PAR do modelo padrão estendido." Universidade Federal do Maranhão, 2011. http://tedebc.ufma.br:8080/jspui/handle/tede/1858.
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Previous issue date: 2011-07-08<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>The CPT-even abelian gauge sector of the Standard Model Extension is represented by the Maxwell term supplemented by KF )µνρσ FµνFρσ, where the Lorentz-violating background tensor, (KF )µνρσ, possesses the symmetries of the Riemann tensorand a double null trace. In the present work, it is examined the planar version of this theory, obtained by means of a dimensional reduction procedure to (1 + 2) dimensions. The resulting planar electrodynamics is composed of a gauge sector containing six Lorentz-violating coe¢ cients, a scalar …eld endowed with a noncanonical kinetic term, and a coupling term that links the scalar and gauge sectors. The parity of the components of the Lorentz violating tensors is analyzed, following the de…nition of the parity operator in (1 +2) dimensions. The equations of motion of the theory are also found, where the electromagnetic …eld appears coupled to scalar …eld. This coupling however appears only as a second order e¤ect on the violation coe¢ cients and thus it is neglected. The energy-momentum tensor of the theory is calculated, revealing contributions of scalar, gauge and coupling sectors. From this tensor it is found a positive energy density de…ned for small violation parameters. The wave equations for the …elds E and B and the potential A0 and A are written and solved in the steady state by the method of Green. It is observed that the Lorentz-violating parameters do not alter the asymptotic behavior of the …elds but induce an angular dependence not observed in the Maxwell planar theory. It is also observed that electrical charges generate static magnetic …eld, as well as stationary currents generate electric …eld, a property already present in the original theory in (1 +3) dimensions. The dispersion relation also is determined, revealing that the six parameters related to the pure electromagnetic sector do not yield birefringence at …rst order. In this model, the birefringence may appear only as a second order efect associated with the coupling tensor linking the gauge and scalar sectors.<br>O setor de gauge abeliano CPT-Par do Modelo Padrão Estendido é representado pelo termo de Maxwell suplementado por (KF )µνρσ FµνFρσ, onde o tensor de campo de fundo violador de Lorentz, (KF )µνρσ, possui as simetrias do tensor de Riemann e um duplo traço nulo. No presente trabalho é examinada a versão planar dessa teoria, obtida por meio do procedimento de redução dimensional para (1+2) dimensões. A eletrodinâmica planar resultante é composta de um setor de gauge contendo seis coe…ficientes de violação de Lorentz, um campo escalar regido por um termo cinético não canônico, e um termo de acoplamento que interliga os dois setores. A paridades das componentes dos tensores violadores de Lorentz é analisada. Também são encontradas as equações de movimento da teoria, onde o campo eletromagnético aparece acoplado ao campo escalar. Este acoplamento, no entanto, aparece apenas como um efeito de segunda ordem nas equações de movimento e por isso é descartado. O tensor de energia-momento da teoria é calculado, apresentando contribuições tanto dos setores escalar e de gauge quanto do de acoplamento. A partir deste tensor é encontrada uma densidade de energia positiva de…nida apenas para pequenas parâmetros de violação. As equações de onda para, os campos E e B e potenciais A0 e A, são escritas e resolvidas no regime estacionário, via o método de Green. Observa-se que os parâmetros de violação de Lorentz não alteram o comportamento assimptótico dos campos, mas induzem uma dependência angular não observada na teoria planar de Maxwell. É também observado que cargas estáticas geram campo magnético, assim como correntes estacionárias geram campo elétrico, uma propriedade já presente na teoria original em (1+3) dimensões. A relação de dispersão também é determinada, revelando que os seis parâmetros relacionados ao setor eletromagnético puro não produzem birrefringência. Neste modelo, a birrefringência pode aparecer apenas como um efeito de segunda ordem associado ao tensor de acoplamento que liga os campos escalar e de gauge.
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Mana, Capelli Sebastian C. "CopB from Archaeoglobus fulgidus a thermophilic Cu²⁺ transporting CPx-ATPase." Link to electronic thesis, 2002. http://www.wpi.edu/Pubs/ETD/Available/etd-0428103-100252/.
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Biloti, Debora Nakai. "Estudos sobre o antineoplasico CPT-11 : I. Interação com albumina de soro humano (HSA) ; II. Encapsulação e caracterização de CPT-11 em lipossomas estericamente estabilizados." [s.n.], 2002. http://repositorio.unicamp.br/jspui/handle/REPOSIP/250360.
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Orientadores : Francisco Benedito Teixeira Pessine, Maria Helena Andrade Santana<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Quimica<br>Made available in DSpace on 2018-08-02T18:34:43Z (GMT). No. of bitstreams: 1
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Coleman, Anne M. "The clinician's experience of working in complex psychological trauma (CPT), gender based violence/childhood sexual abuse : an interpretative phenomenological analysis of the impact of CPT work." Thesis, Glasgow Caledonian University, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.743884.
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Le, Gac Renaud. "Etude de la symétrie CPT dans le système des kaons neutres." Habilitation à diriger des recherches, Université de la Méditerranée - Aix-Marseille II, 1997. http://tel.archives-ouvertes.fr/tel-00002645.
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L'experience CPLEAR est installee au CERN a Geneve. Elle mesure les effets violant CP, T et CPT dans le systeme K0-K0bar. Sa methode est basee sur la determination des asymetries particule-antiparticule en fonction du temps de desintegration, lorsque le kaon neutre se desintegre en 2 Pi, 3 Pi et Pi e nu. Les resultats obtenus permettent de sonder pour la premiere fois toutes les sources de la violation de CPT imaginees a ce jour.
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Granström, Frida. "Portrycksmätning med CPT-sondering : En fallstudie utförd på Västra Länken, Umeå." Thesis, Luleå tekniska universitet, Geoteknologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-66316.
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Vid geotekniska fältundersökningar används ofta ”Cone Penetration Test” (CPT-sondering). Denna metod ger en bedömning av jordlagerföljd samt en uppskattning av de geotekniska egenskaperna. Metoden används i lösa till fast lagrade jordar med kornstorlekar upp till grusfraktion, alltså jordar där en sond kan tryckas ned utan slag eller rotation. När en CPT-spets penetrerar en vattenmättad tät jord sker en omlagring av jorden varvid en lokal ökning av portrycket sker. När ett portrycksutjämningstest utförs, stoppas den nedåtgående rörelsen av sonderingen under en viss tid och portrycket tillåts att klinga av. Det portryck som sedan uppmäts förväntas motsvara det rådande porvattentrycket på nivån. Syftet med denna studie är att utreda om metoden är lämplig att använda vid mätning av portryck samt om den kan ersätta portrycksspetsar i vissa fall, exempelvis vid tidiga skeden av projekt etc. Studien utfördes för att bedöma hur lång tid portrycksutjämningsförsök tar beroende på jordens permeabilitet, om resultatet blir annorlunda om artesiskt portryck råder, hur resultatet skiljer sig beroende på vilken jordtyp försöket utförs i, om resultatet blir liknande som vid mätning med BAT-portrycksspets samt om det går att hitta samband mellan resultat för försök som är utförda i liknande jord. Den geotekniska fältundersökningen genomfördes i Röbäck som är beläget sydväst om Umeå centrum. Fältundersökningen var tidsmässigt begränsat till 3 dagar. Portrycksutjämnings-försöken tilläts pågå under maximalt 2 timmar per nivå eller till dess att portrycksutjämningen klingat av. Undersökningarna är huvudsakligen utförda i sulfidhaltig jord och endast en typ av CPT-utrustning har använts. Inga portryck som uppmättes vid portrycksutjämningsförsöken var lägre än de som mättes i de installerade portrycksspetsarna för samma nivå. Det tog längre tid för portrycket att klinga av där försöket utfördes på större djup under markytan. Resultatet blev inte annorlunda på de platser där artesiskt portryck uppmätts. Denna studie indikerar att en väntetid på 2 timmar i denna typ av jord endast var tillräckligt lång tid för portrycksutjämningstest ned till ca 7 meter under markytan. I jord med låg permeabilitet, så som i denna fallstudie, blir väntetiderna vid varje stopp väldigt långa. Detta försvårar det praktiska utförandet i fält.
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Taloyan, Zoran. "Jämförelse mellan CPT-sondering och CRS-försök med avseende på deformationsegenskaper." Thesis, Uppsala universitet, Institutionen för geovetenskaper, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-351718.
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Deformationsmoduler förklarar hur ett material eller ett område beter sig och deformeras vid olika laster. CRS-försök, komprimerar prover under en konstant deformationshastighet med erhållna moduler såsom: M0 och ML, med hjälp av rutinundersökning. Vid CPT-sondering penetrerar en konisk spets kontinuerligt genom en jordlagerföljd, med erhållen modul: Elasticitets-modul. Metoderna är väldigt olika vad gäller erhållna parametrar, moduler, deformationsgrupper och användning. CRS-försök genomförs laborativt, med prover tagna på vissa specifika djup, medan CPT-sondering genomförs in-situ med information om hela jordlagerföljden som ges. Att jämföra de olika metodernas moduler mellan varandra är inte möjlig, eftersom CONRAD som utvärderar och presenterar CPT resultat, inte utvärderar elasticitets-moduler för lera, utan för friktionsjord. Dem kompletterar varandra väldigt bra, då i områden som i Uppsala som har en med stor mäktighet av lera, visar med CRS-försök att det är lera som är närvarande för att sedan när CPT- sondering börjar registrera Elasticitets-moduler visar på att friktionsjord har påträffats. På så sätt kan deformationsegenskaper för en hel jordlagerföljd erhållas för en borrpunkt. Borrpunkter från Kronåsen och Kungsängen i Uppsala kommun, och Fyrklövern i Upplands Väsby kommun har undersökts med avseende på deformationsegenskaper och resultatet visar på stora skillnader i deras deformationsmoduler sinsemellan.<br>Deformation modules explains how a material or an area behave or deform when different amount of stresses act on it. CRS-testing, which compresses samples with a constant deformation rate, gives us modules like M0 and ML, with the help of routine examinations. CPT-probing, on the other hand, penetrate a conical tip through stratigraphy and gives us the elasticity module. These methods are very different in many ways, like what parameters, modules, deformation groups and use, are given. CRS-testing is conducted in a laboratory, with samples taken from specific depths, while CPT-probing is conducted in the field, with information about the whole stratigraphy is given. To directly compare these two methods modules are not possible. Due to CONRAD that evaluates and present CPT-probing results, does not evaluate elasticity modules for clay, but only for frictional soils. They complement each other very well due to in areas like Uppsala, which has a great depth of clay, shows with CRS-testing that clay is present but when CPT starts to register elasticity modules, shows that we moved in to frictional soil. With this, deformation properties can be shown for the whole stratigraphy in a drill point. Drill points from Kronåsen and Kungsängen in Uppsala municipality, and in Fyrklövern from Upplands Väsby municipality has been evaluated with respect to deformation properties and the results shows great differences in the deformation modules between themselves.
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Svensson, Axel. "Jämförelse av odränerad skjuvhållfasthet mellan CPT-sondering och fallkonförsök på Uppsalalera." Thesis, Uppsala universitet, Institutionen för geovetenskaper, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-325059.
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The knowledge about the shear strength of a soil is important because it is a key parameter that is used in many calculations in construction engineering. Some examples of what’s possible to calculate are slope stability, the soil pressure against retaining walls and the carrying capacity of building foundations. Great economic losses or, in the worst case scenario the risk for human lives, could be the result if the geotechnical properties of the soil are ignored. This report considers the undrained shear strength of clay from Uppsala. There are different methods based on empirical experiences which are used to determine the undrained shear strength of a clay. In this project the methods and the results in undrained shear strength are compared between CPT-probing, which is carried out in-situ, and the drop cone test which is done in a laboratory. The reason for this comparison is that they usually don’t show the same results.The tests had already been made before this project started and therefore it is only the comparison of the results between the methods that has been done. The comparison was done by creating charts in Excel where the results from CPT and the drop cone test from was put together from the same point. The shear strength values from the methods were also statistically analysed with a t-test to see if they show the same hypothetical expected value with 95 % significance in every test point<br>Kunskap om skjuvhållfastheten är viktig då den används för beräkningar inom byggoch anläggningsbranschen. Exempel på vad som kan beräknas är släntstabilitet, jordtrycket mot en spont eller bärförmågan hos en byggnadsgrund. Stora ekonomiska förluster och i värsta fall fara för människoliv kan bli resultatet om jordens geotekniska egenskaper ignoreras. Denna rapport tar upp den odränerade skjuvhållfastheten i Uppsalalera. Det finns olika metoder som bygger på empiriska erfarenheter som kan användas för att ta reda på den odränerade skjuvhållfastheten i lera. I föreliggandeprojekt jämförs metoderna och resultaten i odränerad skjuvhållfasthet mellan CPT-sondering som utförs in-situ och fallkonförsök som utförs på lerprover i ett laboratorium. Anledningen till studien är att metoderna inte alltid ger samma mätvärden. Undersökningarna utfördes innan projektet började. Jämförelsen har gjorts genom den statistiska jämförelsen t (student)-test. Resultatet från t-testet visar att skjuvhållfasthetsvärdena från CPT respektive fallkonförsöken från samma undersökningspunkt och från samma nivå har samma hypotetiska förväntade värde på 95 % signifikansnivå. Genom sammanställda grafer syns att metoderna i de flesta fall överensstämmer till ett djup på minst 20 m.
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Furlan, Andrej. "Fullerene-like CNx and CPx Thin Films; Synthesis, Modeling, and Applications." Doctoral thesis, Linköping : Department of Physics, Chemistry and Biology, Linköpings universitet, 2009. http://www.bibl.liu.se/liupubl/disp/disp2009/tek1247s.pdf.
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NUTINI, IRENE. "The CUORE experiment: detector optimization and modelling and CPT conservation limit." Doctoral thesis, Gran Sasso Science Institute, 2019. http://hdl.handle.net/10281/342915.
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My PhD thesis project has been carried out within the CUORE (Cryogenic Underground Observatory for Rare Events) experiment. The CUORE experiment is a ton scale cryogenic detector installed in the underground Gran Sasso laboratories of INFN (LNGS) in Italy. The CUORE detector consists of an array of 988 TeO2 bolometric detectors (5 x 5 x 5 cm3 each) arranged into 19 identical structures called 'towers'. Each tower hosts 52 bolometers arranged in 13 floors, each containing 4 crystals. Each crystal has a mass of 750 g, resulting in a total mass of 742 kg of TeO2, or 206 kg of 130Te. The goal of the CUORE experiment is to investigate the 0nuBB decay of 130Te. My main activities have been related to the CUORE detector operation, characterization and optimization. Moreover I developed software tools for the CUORE data processing and analysis. In addition, I have been investigating the CUORE sensitivity to rare processes other than the 0nuBB decay, like the CPT symmetry violation in the 2nuBB decay. In the first part of my PhD thesis, I give a detailed review of the CUORE detector optimization campaigns performed in 2017. It was the first time that such a large number of bolometric detectors were simultaneously operated in a completely new and unique cryogenic system. My main contribution has been related to the analysis of the detectors performance in terms of signal optimization and noise reduction, in order to set both the optimal operating temperature of the cryogenic system and the polarization voltages (working points) for the NTDs coupled with each bolometer. In order to set the best operating conditions of the CUORE detectors, it has been necessary to characterize the response of the CUORE bolometers and NTDs. Utilizing the high number of detectors in CUORE, it was possible to study and model more features of the bolometers response and to try to develop a complete (static and dynamic) thermal model. The development of a thermal model can contribute to the identification of the physical parameters which are affecting the CUORE bolometers energy resolution and which could be possibly better optimized. The second part of the work is focused on the analysis of the CUORE data and on the study of the potential of the CUORE experiment for the search for rare events and/or for physics beyond the Standard Model other than the 0nuBB decay of 130Te. The first CUORE physics data were acquired during the summer of 2017, with a total collected 0nuBB exposure of 86.3 kg.yr of (nat)TeO2. The analysis of these data lead to the first CUORE 0nuBB half-life limit and to a more precise measurement of the 2nuBB decay half-life for 130Te. I have contributed to the analysis by developing and debugging the software for processing and analyzing the CUORE data; moreover I have worked to the evaluation of the selection efficiencies which have been used in the production of the CUORE physics results. Furthermore I studied the sensitivity of the CUORE experiment to the possible CPT symmetry violating terms. Indeed, the violation of this symmetry is described in several Standard Model Extensions (SME); in the case of isotopes which can undergo double-beta decay, the CPT violation would induce a deformation in the spectrum of the total energy of the two electrons emitted in the 2nuBB process. Utilizing the data acquired by CUORE in 2017, it was possible to set the first limit for the CPT violation evaluated from the 130Te isotope.
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NUTINI, IRENE. "The CUORE experiment: detector optimization and modelling and CPT conservation limit." Doctoral thesis, Gran Sasso Science Institute, 2019. http://hdl.handle.net/20.500.12571/9707.
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Galassi, Gabriele. "Valutazione del potenziale di liquefazione di depositi alluvionali con prove CPTU nell'area di Sant'Agostino (Fe)." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2020.
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Per i depositi presenti nell'area di Sant'Agostino (FE) ho provveduto alla valutazione della suscettubilità alla liquefazione. Ho verificato l'influenza della massima accelerazione orizzontale del terreno e del peso dell'unità di volume nel calcolo del potenziale di liquefazione. Infine ho confrontato i risultati ottenuti con quelli presenti in letteratura.
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Medeiros, Renata dos Santos. "Dimensão territorial da Companhia Paulista de Trens Metropolitanos (CPTM) e suas especificidades organizacionais e laborativas." Presidente Prudente, 2011. http://hdl.handle.net/11449/190894.
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Orientador: Antonio Thomaz Júnior<br>Banca: Luis Antonio Barone<br>Banca: Marcelo Dornelis Carvalhal<br>Resumo: O objetivo geral desta investigação foi proceder a uma análise geográfica da organização da Companhia Paulista de Trens Metropolitanos - CPTM, focando a investigação em suas especificidades organizacionais e laborativas. Este trabalho buscou ampliar os estudos acerca das consequências do projeto neoliberal adotado e vastamente difundido pelo governo brasileiro entre o final da década de 1980 e início dos anos 1990. Os setores de infra-estrutura no Brasil, entre eles o setor ferroviário passaram a ter características marcantes de uma reorganização produtiva e gerencial que alterou estruturalmente as relações de trabalho no interior das empresas, outrora exclusivamente estatais. No cenário paulista, a criação de uma empresa de economia mista, voltada ao transporte público, que viesse a gerenciar as atividades do setor de passageiros e que atenderia uma região de relevante importância geoeconômica, solidificou os princípios dos investimentos privados, cada vez mais em expansão nas empresas brasileiras na década de 1990. Solidificou-se, todavia, um "despertar" dos reais papéis do Estado, que passou a garantir um status empresarial e empreendedor frente às parcerias público-privadas e aos investimentos que marcaram o surgimento da CPTM. Buscamos inicialmente compreender como o desenvolvimento regional condicionou o processo de integração urbana, que, por ora resultou na espacialização da Região Metropolitana de São Paulo e nos propusemos a entender como os impactos mais subjetivos do processo de reestruturação produtiva tiveram seus rebatimentos na organização espacial no plano da metrópole ... (Resumo completo, clicar acesso eletrônico abaixo)<br>Abstract: The general purpose of this research was to conduct a geographic analysis of the organization of the Companhia Paulista de Trens Metropolitanos, CPTM, (São Paulo Company of Metropolitan Trains) focusing on their organizational and laboural specific aspects. This work proposed to extend those studies about the consequences of the neoliberal project, adopted and widely spread by the Brazilian government between the end of the 1980 decade and the beginning of 1990. The sectors of infrastructure in Brazil, especially those of the railway industry, started to have marked characteristics of a productive and managerial reorganization which structurally changed the labour relations inside corporations previously run only by the State. In the São Paulo scene, the creation of a company of mixed economy devoted to public transport which would manage the activities of the sector of passengers and would attend to an area of relevant geoeconomic importance consolidated the principles of private investments, in gradual expansion during the 1990 decade. However, an "awakening" of the real roles of the State took place. The State started to hold the status of both enterprise and entrepreneur in front of the public-private associations and the investments which signalled the emergence of CPTM. Initially we tried to understand how a regional development conditioned the process of urban integration which resulted in the spacialization of the São Paulo Metropolitan Region and we proposed to understand how the most subjective impacts of the productive restructuration process were objected to in the space organization of the metropolis plan ... (Complete abstract click electronic access below)<br>Mestre
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SILVA, Moisés Pereira da. "Padre Josimo Moraes Tavares E A Atuação Da Comissão Pastoral Da Terra (Cpt) Nos Conflitos Agrários Do Araguaia-Tocantins." Universidade Federal de Goiás, 2011. http://repositorio.bc.ufg.br/tede/handle/tde/2317.
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Previous issue date: 2011-05-05<br>This thesis is focused on research on the trajectory of the priest Josimo Moraes Tavares, as well as a review of the interpretive sense of the historical-political work of the Araguaia -Tocantins CTP, as a mediator of land conflicts in Amazonia, especially in a region named Bico do Papagaio the 1970s e 1980s. Land conflicts in Amazonia in this period brought light the nation‟s problems, even more so after several intellectuals scholars who wrote on the subject, the dramatic social struggle over land over land ; the struggle of the peasant who understood the land like a means of survival, opposition people who understood the ground just as speculation and possibility of profit made by the subjection of man by man. On the hand the squatter, a category of the Brasilian peasantry on the other hand the capitalist. The work of the priest Josimo, engangent model in favor of squatters in the middle of a social classes conflict, expressed as a political option pastoral forward other options expressed by all of the Araguaia Tocantins. Is that it treats this dissertation, fighting and political options of a priest whitin a context of struggle of social classes the ideological and political trajectory of an intellectual integrated with an important institution of the Catholic Church: the Pastoral Land Commission CTP Araguaia-Tocantins who was assassinated for defending the right of peasants to land tenure. The historical analysis developed here on the meanings his death and the multiple interpretations of it, especially those that present either as a martyr, either as an offender completes the meaning of thesis.<br>A presente dissertação está centrada numa investigação sobre a trajetória do Padre Josimo Moraes Tavares, assim como numa análise interpretativa do sentido histórico-político do trabalho da CPT Araguaia-Tocantins enquanto mediadora dos conflitos de terra na Amazônia, em especial no Bico do Papagaio nas décadas de 1970 e 1980. Os conflitos de terra na Amazônia nesse período desnudaram ao país, mais ainda depois do que vários estudiosos escreveram sobre o assunto, as dramáticas lutas sociais pela posse da terra; a luta dos camponeses que entendiam a terra como meio de vida, oposta aos que compreendiam a terra apenas como especulação e possibilidade de lucro auferido mediante a sujeição do homem pelo homem. De um lado o posseiro, uma categoria do campesinato brasileiro, do outro o capitalista. É ante esse efetivo conflito de classe que o trabalho do Padre Josimo, modelo de engajamento em favor dos posseiros, manifestou-se como opção político-pastoral frente às demais opções expressas pelo conjunto da CPT Araguaia-Tocantins. É disso que trata essa dissertação, da luta e opções políticas de um padre dentro de um contexto de luta de classe; da trajetória ideológica e política de um intelectual integrado a uma importante instituição da Igreja Católica: a Comissão Pastoral da Terra (CPT) Araguaia-Tocantins que foi assassinado por defender o direito dos camponeses à posse da terra. A reflexão historiográfica aqui desenvolvida sobre os significados da sua morte e as múltiplas interpretações sobre ela, principalmente aquelas que o apresentam ora como um mártir, ora como um criminoso complementa o sentido desta dissertação.
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JÃnior, Roberto CÃsar Pereira Lima. "Estudo morfofuncional e dos mediadores inflamatÃrios envolvidos na patogÃnese da mucosite intestinal induzida por irinotecano (CPT-11) em camundongos: papel da caspase-1, interleucina-18 e Ãxido nitrÃco." Universidade Federal do CearÃ, 2008. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=1676.
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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>IntroduÃÃo: A Mucosite Intestinal (MI) e a diarrÃia severas sÃo efeitos colaterais freqÃentes (15-25%) e limitantes da quimioterapia do cÃncer de cÃlon com Irinotecano (CPT-11). Atà o presente momento, pouco se conhece sobre a fisiopatologia da MI. Objetivo: Estudar os mecanismos e mediadores envolvidos na mucosite intestinal induzida por CPT-11, verificando a participaÃÃo da protease caspase-1, das citocinas interleucina-1 (IL-1), interleucina-18 (IL-18) e interleucina-33 (IL-33), do Ãxido nÃtrico, de mediadores 5-lipoxigenase e do PAF, assim como a seqÃÃncia de interaÃÃo entre esses mediadores sob aspectos da resposta inflamatÃria e morfofuncionais. MÃtodos: Camundongos Swiss, C57BL/6 (BL), BALB/c (BC) ou knockout para Caspase-1 (Casp-/-), IL-18 (IL-18-/-), Ãxido nÃtrico sintase induzida (iNOS-/-), 5-Lipoxigenase (5-LOX-/-), receptor para PAF (PAFr-/-) machos, 22 g, foram divididos em grupos (n=4-5) e tratados por 4 dias com salina (5 mL/kg, i.p) ou CPT-11 (60 mg/kg, i.p) ou foram prÃ-tratados com IL-18bp (proteÃna ligante de IL18, 200 Âg/animal/4 dias, i.p.), aminoguanidina (AG, 50 mg/kg, s.c, 2x/dia/4 dias), IL-33 (1 Âg/animal/4 dias, i.v, 1h antes do CPT-11) ou loperamida ([4x3 mg/kg e 4x30 mg/kg]/animal, s.c.) em associaÃÃo com CPT-11. No 5 dia, avaliou-se a diarrÃia por escores, o leucograma e, apÃs sacrifÃcio, coletou-se o duodeno para dosagem da atividade de mieloperoxidase (MPO, neutrÃfilos/mg tecido) e de Ãxido nÃtrico sintase induzida (iNOS pM citrulina/h/mg proteÃna), morfometria (razÃo vilo/cripta) e contratilidade in vitro à Acetilcolina (%contraÃÃo em relaÃÃo ao KCl60 mM). Para anÃlise estatÃstica utilizou-se ANOVA/Newman-Keuls ou Kruskal Wallis/Dunn. P<0,05 foi aceito. Resultados: Camundongos BL apresentaram um padrÃo de mucosite intestinal similar ao observado no camundongo Swiss sob aspectos morfofuncionais. O CPT-11 induziu leucopenia em todos os animais independentemente do tratamento aplicado. Adicionalmente, o CPT-11 induziu em animais BL e BC, nÃo tratados, aumento de MPO intestinal, reduÃÃo da relaÃÃo vilo/cripta, amento da contratilidade in vitro e dos eventos de diarrÃia comparados com animais injetados somente com salina (p<0,05). A despeito da administraÃÃo de CPT-11, animais Caspase-1-/-, IL-18-/- ou BC tratados com IL-18bp apresentaram atividade de MPO e de iNOS reduzidas, bem como aumento na relaÃÃo vilo/cripta, menor contratilidade duodenal in vitro e eventos de diarrÃia atenuados em comparaÃÃo aos respectivos controles tratados com salina (p>0,05). Dados idÃnticos tambÃm foram observados em camundongos injetados com IL-33 e que receberam CPT-11. A reduÃÃo na atividade de iNOS naqueles animais motivou o estudo do efeito do CPT-11 em animais iNOS-/- ou tratados com aminoguanidina. Observaram-se menores nÃveis de citocinas IL-1beta e KC, bem como uma atividade de MPO reduzida no duodeno desses animais. AlÃm disso, verificou-se preservaÃÃo da relaÃÃo vilo/cripta e da espessura da camada muscular, menor contratilidade duodenal in vitro e eventos de diarrÃia atenuados similar ao observado nos respectivos controles que receberam apenas salina (p>0,05). PorÃm, a administraÃÃo de CPT-11 a animais PAFr-/- foi capaz de induzir alteraÃÃes morfofuncionais e o aumento da atividade de MPO intestinal. Em camundongos 5-LOX /- ou tratados com loperamida (controle positivo), ambos os grupos injetados com CPT-11, observaram-se aumento da atividade de MPO e alteraÃÃes morfomÃtricas. Contudo, sobre aspectos funcionais de contratilidade in vitro, visualizou-se proteÃÃo. ConclusÃes: Esses resultados sugerem que a via caspase-1-IL-18 Ãxido nÃtrico contribui para o desenvolvimento da resposta inflamatÃria e alteraÃÃes morfofuncionais na mucosite intestinal induzida por CPT-11. A IL-33 parece ser um fator protetor compensatÃrio nessa cascata inflamatÃria. A 5-LOX e o PAFr parecem ter papel secundÃrio na patogÃnese da mucosite intestinal por CPT-11.<br>Introduction: Severe Intestinal Mucositis (IM) and diarrhea are frequent and dose-limiting side-effects of colon cancer chemotherapy with irinotecan (CPT-11). At present, much of IM pathophysiology remains unknown. Aims: To study the mechanisms and inflammatory mediators involved in CPT-11-induced intestinal mucositis, verifying the role of the protease caspase-1, cytokines interleukin-1 (IL-1), interleukin-18 (IL-18) and interleukin-33 (IL-33), nitric oxide, 5-lipoxygenase and PAF as well as the sequence of activation of these mediators in the inflammatory response and morphofunctional contexts. Methods: Swiss, C57BL/6 (BL), BALB/c (BC) male mice or caspases-1(Casp-1-/-), IL-18 (IL-18-/-), inducible nitric oxide synthase (iNOS-/-), 5-Lipoxygenase (5-LOX-/-), PAF receptor (PAFr-/-) knockout mice, 22g, were divided into groups (n=4-5) and treated for 4 days with saline (5 mL/kg, i.p.) or CPT-11 (60 mg/kg, i.p.) or were given IL-18bp (IL-18 binding protein, 200 Âg/animal/4 days, i.p.), aminoguanidine (AG, 50 mg/kg, s.c, 2x/day/4 days), IL-33 (1 Âg/animal/4 days, i.v, 1h previously CPT-11) or loperamide ([4x3 mg/kg and 4x30 mg/kg]/animal, s.c.) co-administered with CPT-11. On day 5, diarrhea and leukocyte counts were assessed, and following sacrifice duodenal portions of the animal were collected to assess myeloperoxidase (MPO, neutrophils/mg tissue) and nitric oxide synthase (iNOS pM citruline /h/mg protein) activity, morphometric analysis, and in vitro contractility (%contraction in relation to KCl 60 mM). ANOVA/Newman Keuls or Kruskal Wallis/Dunn were used as statistical tests. P<0.05 was accepted. Results: IM was morphofunctionally similar in both BL and Swiss. CPT-11 induced leukopenia in all animal lineages despite the treatment given. Additionally, CPT-11 induced MPO, increased in vitro contractility and diarrheic events, and villi/crypt ratio reduction in BL and BC mice in comparison with saline treated mice (p<0.05). Despite the injection of CPT-11, Casp-1-/-, IL-18-/- or IL-18bp treated BC mice presented reduced MPO and iNOS activities and also increased villi/crypt ratio, reduced duodenal in vitro contractility and mild diarrhea similar to saline-treated mice (P>0.05), similar to the patterns seen in IL-33 treated mice. The reduced iNOS activity found in the earlier mice led us to investigate the CPT-11 effect on iNOS /- and aminoguanidine-treated mice. Lower IL-1beta and KC cytokine levels, as well as reduced MPO activity were found. Also, preserved villi/crypt ratio and muscle layer thickness, normal duodenal contractility and diarrheic events were seen similarly to saline-treated mice (p>0.05). However, CPT-11-treated PAFr-/- presented morphofunctional alterations and increased intestinal MPO activity. 5-LOX-/- or loperamide treated mice (positive control), both injected with CPT-11, exhibited increased MPO activity and morphometric alterations, but no exacerbation on in vitro contractility was observable. Conclusion: Taken together, these results suggest the role of caspase-1/Interleukin-18/nitric oxide cascade on pathogenesis of CPT-11-induced morphofunctional alteration and inflammatory response (IM). IL-33 seems to be a compensatory protective factor on this inflammatory cascade. 5-LOX and PAFr show a likely secondary role on IM pathophysiology.
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Lesnicki, Krzysztof Jacek. "Nonlinear resonance methods for assessing ASR susceptibility during concrete prism testing (CPT)." Thesis, Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/41054.
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This research focuses on the characterization of damage accumulation in concrete specimens. Specifically, a nonlinear vibration technique is used to characterize the damage introduced by ongoing alkali-silica reactions (ASR). The nonlinear resonance testing consists of an analysis of the frequency response of concrete specimens subjected to impact loading. ASR introduces a third gel like phase, which can be expansive in the presence of moisture. The result of ASR is the formation of microcracks and debonding between aggregate and cement phases. Collectively, these changes act to increase the specimens' nonlinearity. As a result, it is found that the concrete samples exhibit nonlinear behavior; mainly a decrease in resonance frequency with an increasing level of excitation strain. The relationship between the amplitude of the response and the amount of frequency shift is used as a parameter to describe the nonlinearity of the specimen. The specimens used in this research are of varying reactivity with respect to ASR, which is induced in accordance with ASTM C 1293. The level of nonlinearity is used as a measure of damage caused by the progress of ASR throughout the one year test duration. These nonlinear resonance results are compared to the traditional measures of expansion described in the standard. The robustness and repeatability of the proposed technique is also investigated by repeated testing of samples assumed to be at a specific damage state. Finally, a petrographic staining technique is used to complement nonlinearity measurements and to further gain understanding of ASR. The results of this study show that the proposed nonlinear resonance methods are very sensitive to microstructural changes and have great potential for quantitative damage assessment in concrete.
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Costa, Lúcio Campos [UNESP]. "Estudo da violação das simetrias de Lorentz e CPT na eletrodinâmica quântica." Universidade Estadual Paulista (UNESP), 2004. http://hdl.handle.net/11449/102501.
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costa_lc_dr_ift.pdf: 1010600 bytes, checksum: bc05c2dfbdfafca45a21ea8884cb5c3f (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Na presente tese, investiga-se uma versão estendida da eletrodinâmica quântica, onde se introduz um termo de acoplamento axial renormalizável não invariante, dando ênfase à quebra dinâmica das simetrias de Lorentz e CPT no setor de gauge e à ambigüidade no coeficiente do termo do tipo Chern-Simons, induzido através de correções radiativas e outros métodos não perturbativos. Aspectos da teoria efetiva de Euler-Kockel-Heisenberg a tempertura finita também são investigados à luz do formalismo conhecido como Thermo Field Dynamics.<br>In the present thesis it is investigated an extended version of quantum electrodynamic where a renormalized non-invariant axial coupling term introduced, emphasizing the dynamic violation of the Lorentz and CPT symmetries in the gauge sector of the theory as well as the ambiguity of the coeficient of the Chern-Simon-like term, induced through radiative corrections and other non-perturbative methods. Some aspects of the Euler-Kockel-Heisenber effective theory at finite temperature have also been addressed in the context of the Thermo Field Dynamics formalism.
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Auty, David John. "Testing CPT conservation using the NuMI neutrino beam with the MINOS experiment." Thesis, University of Sussex, 2010. http://sro.sussex.ac.uk/id/eprint/2456/.
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The MINOS experiment was designed to measure neutrino oscillation parameters with muon neutrinos. It achieves this by measuring the neutrino energy spectrum and flavour composition of the man-made NuMI neutrino beam 1km after the beam is formed and again after 735 km. By comparing the two spectra it is possible to measure the oscillation parameters. The NuMI beam is made up of 7.0% μ, which can be separated from the μ because the MINOS detectors are magnetised. This makes it possible to study μ oscillations separately from those of muon neutrinos, and thereby test CPT invariance in the neutrino sector by determining the μ oscillation parameters and comparing them with those for μ, although any unknown physics of the antineutrino would appear as a difference in oscillation parameters. Such a test has not been performed with beam μ before. It is also possible to produce an almost pure μ beam by reversing the current through the magnetic focusing horns of the NuMI beamline, thereby focusing negatively, instead of positively charged particles. This thesis describes the analysis of the 7% μ component of the forward horn current NuMI beam. The μ of a data sample of 3.2×1020 protons on target analysis found 42 events, compared to a CPT conserving prediction of 58.3+7.6 −7.6(stat.)+3.6 −3.6(syst.) events. This corresponds to a 1.9 deficit, and a best fit value of m2 32 = 18 × 10−3 eV2 and sin2 223 = 0.55. This thesis focuses particularly on the selection of μ events, and investigates possible improvements of the selection algorithm. From this a different selector was chosen, which corroborated the findings of the original selector. The thesis also investigates how the systematic errors affect the precision of m2 32 and sin2 223. Furthermore, it describes a study to determine the gains of the PMTs via the single-photoelectron spectrum. The results were used as a crosscheck of the gains determined at higher intensities by an LED-based light-injection system.
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Costa, Lúcio Campos. "Estudo da violação das simetrias de Lorentz e CPT na eletrodinâmica quântica /." São Paulo : [s.n.], 2004. http://hdl.handle.net/11449/102501.
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Orientador: Jeferson de Lima Tomazelli<br>Banca: José Francisco Gomes<br>Banca: Maria Cristina Batoni Abdalla<br>Banca: Josif Frenkel<br>Banca: Tereza Cristina da Rocha Mendes<br>Resumo: Na presente tese, investiga-se uma versão estendida da eletrodinâmica quântica, onde se introduz um termo de acoplamento axial renormalizável não invariante, dando ênfase à quebra dinâmica das simetrias de Lorentz e CPT no setor de gauge e à ambigüidade no coeficiente do termo do tipo Chern-Simons, induzido através de correções radiativas e outros métodos não perturbativos. Aspectos da teoria efetiva de Euler-Kockel-Heisenberg a tempertura finita também são investigados à luz do formalismo conhecido como Thermo Field Dynamics.<br>Abstract: In the present thesis it is investigated an extended version of quantum electrodynamic where a renormalized non-invariant axial coupling term introduced, emphasizing the dynamic violation of the Lorentz and CPT symmetries in the gauge sector of the theory as well as the ambiguity of the coeficient of the Chern-Simon-like term, induced through radiative corrections and other non-perturbative methods. Some aspects of the Euler-Kockel-Heisenber effective theory at finite temperature have also been addressed in the context of the Thermo Field Dynamics formalism.<br>Doutor
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Cohen, Andrew Laurence Shapiro Steven K. "Performance on the flicker task and Conners' CPT in children with ADHD." Auburn, Ala, 2009. http://hdl.handle.net/10415/1887.
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Campigoto, Jose Adilçon. "Roças empresas e sonhos: jogos e discursos (A CPT em Santa Catarina)/." reponame:Repositório Institucional da UFSC, 1996. https://repositorio.ufsc.br/handle/123456789/112202.
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Mettler, Eunice. "Continuing Professional Teacher Development (CPTD) practices of teachers in working class schools in the Western Cape." University of the Western Cape, 2016. http://hdl.handle.net/11394/5355.
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Magister Educationis (Adult Learning and Global Change) - MEd(AL)<br>Continuing Professional Teacher Development (CPTD) of teachers at working class schools in South Africa has come under scrutiny over the past few years. Despite new education policies which incorporated the dire need for CPTD, the achievement of learners at working class schools remains poor. This investigation was prompted by the cause of this discrepancy. This study investigates the participation of teachers in Continuous Professional Development initiatives at working class schools in the Western Cape. The primary research question for this research paper is: “Why are teachers at working class schools not participating in CPTD initiatives as expected?” A qualitative approach within the interpretive paradigm was adopted throughout this study. The interpretive approach allowed the researcher to gain a more social world interpretation of the respondents as it provided insight in CPTD practices at working class schools. The process of data gathering was inductive as information emerges from interviews and questionnaires. Open-ended questionnaires and semi-structured interviews were used to gather data. The study comprised 15 respondents and included teachers at two schools and three officials from the Department of Education. The demographics of the two schools were similar which made it possible to ask the same questions for all respondents. The study highlighted the lack of participation of teachers in CPTD due to human, material and financial constraints. Urgent consideration needs to be given to eradicating these barriers for continuous professional development of teachers. Providers of CPTD should ensure that the needs of teachers are met and training should be embarked upon on a continuous basis. In addition, priority should be given to teachers employed at schools in working class areas.
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MASTRANGELI, FRANCESCA. "Clasterina (clu) e carnitinpalmitoiltransferasi (cpt1): due nuovi marcatori metabolici e potenziali target terapeutici nell’osteoporosi ed osteoartrosi." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2016. http://hdl.handle.net/2108/203084.
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Garpefjäll, Matilda, and Hugo Hildingsson. "Evaluation of cone factors for CPT-evaluation in CONRAD of sulphide- bearing soil in Mälardalen." Thesis, KTH, Jord- och bergmekanik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-280484.
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The purpose of this master thesis is to investigate how to evaluate CPT-soundings in sulphide soilfrom Mälardalen in CONRAD. The objective is to conclude whether sulphide soil from Mälardalenshould be evaluated with existing methods or a new method should be developed. The only existingevaluation methods for sulphide soil are empirically derived for sulphide soil along the coast of Gulfof Bothnia known as Svartmocka. There are currently no guidelines for when to use this evaluationmethod. In the industry, sulphide soil in Mälardalen is evaluated as clay for lack of alternatives, butthis solution has no scientific basis. There is therefore a need for an extended investigation on howsulphide soil from Mälardalen should be evaluated. Previous research has been summarized and provides the basis for the design of the analysis method. Geotechnical investigation data from two sites have been collected and analysed: Spångadalen, innorthwest Stockholm and part of the new railway Norrbotniabanan located north of Umeå in thenorthern part of Sweden. At Spångadalen, the main reason for the investigation is the construction oftwo storm water management ponds. Here some extended laboratory experiments have been carriedout to supplement existing data.Since the purpose of this thesis is to investigate how to evaluate the sulphide soil in Mälardalen, thedata from Spångadalen has be evaluated both with the method for clay and sulphide soil. The datafrom Norrbotniabanan has only been evaluated as sulphide soil. The comparison between theevaluation methods and areas is bases on the difference between the different investigation methods. The parameters of undrained shear strength, pre-consolidation pressure and overconsolidation ratiofrom CPT-soundings has been compared with the same parameters from direct shear tests, fall conetests, field vane tests and CRS. The comparison has also included the spread of the evaluated CPTs indifferent areas. Further the cone factors for the undrained shear strength and pre-consolidationpressure in the empirical equations in CONRAD has been evaluated for the soil in Spångadalen. Theevaluated in based on the evaluation of the CPT preformed in CONRAD and values for the undrainedshear strength and pre-consolidation pressure from other reference methods. The cone factors for theundrained shear strength and pre-consolidation pressure were then compared to the existing conefactors.The conclusion is that no significant results indicates that sulphide soil in Mälardalen differs fromclay although it shares some characteristic with the sulphide soil from Norrbotniabanan. Sulphidesoil from Spångadalen should not even be called sulphide soil since the amount of sulphide was toolow, which was discovered during the study. It should instead be called clay with elements of sulphide. Sulphide soil from Mälardalen should therefore continue to be evaluated as clay. However, furtherresearch on the subject is needed to ensure this conclusion for other areas with sulphide soil in Mälardalen.<br>Syftet med denna examensuppsats är att undersöka hur CPT-undersökningar I sulfidjord från Mälardalen bör utvärderas i CONRAD. Målet är att genom analys finna underlag för slutsatser,antingen för att sulfidjord från Mälardalen bör utvärderas med befintliga metoder eller att en nyutvärderingsmetod bör utvecklas. De befintliga utvärderingsmetoderna för sulfidjord är empiristbaserade på sulfidjord längst med kust av Bottenviken, känd som Svartmocka. Idag saknas detriktlinjer för när denna ut metod ska användas och i branschen utvärderas sulfidjord från Mälardalensom lera i brist på alternativ. Denna lösning saknar dock vetenskaplig grund. Det finns därför ettbehov av en utökad undersökning kring hur sulfidjord från Mälardalen bör utvärderas.Tidigare forskning har sammanställts och lagat till grund för utformningen av analysmetoden.Geotekniska undersökningsdata från två områden har samlats in och analyserats. Ett område ligger iSpångadalen väster om Stockholm i Mälardalen. Det huvudsakliga skälet till undersökningarna ärbyggandet av två dagvattendammar. Det andra området ligger norr om Umeå i norra delen av Sverige.De undersökningarna kommer från en del av den nya järnvägen Norrbotniabanan. I Spångadalen harutökade laboratorieförsök utförts som komplement till befintliga data.Då syfte med denna uppsats är att undersöka hur sulfidjord i Mälardalen bör utvärderas harundersökningarna från Spångadalen utvärderats med metoderna för både lera och sulfidjord.Undersökningarna från Norrbotniabanan har endast utvärderats som sulfidjord. Jämförelsernamellan de olika utvärderingsmetoderna och utvärderingsmetoderna baseras på skillnaderna mellande olika undersökningsmetoderna. Parametrarna för odränerad skjuvhållfasthet,förkonsolideringstryck och överkonsolideringsgrad från CPT-sonderingarna har jämförts medsamma parametrar från direkt skjuvförsök, fallkonförsök, vingförsök och CRS. Jämförelseninkluderar också spridningen av de utvärderade CPT-sonderingarna i olika områden.Fortsättningsvis har konfaktorerna för den odränerade skjuvhållfastheten ochförkonsolideringentrycket i de empiriska ekvationerna för CONRAD utvärderats för jorden iSpångadalen. Utvärderingen baserades på CPT resultaten från CONRAD och värden för denodränerade skjuvhållfastheten och förkonsolideringstrycket från andra referensmetoder.Konfaktorerna för den odränerade skjuvhållfastheten och förkonsolideringstrycket jämfördes sedanmed de befintliga konfaktorerna.Slutsatsen är att inga signifikanta resultat visar på att sulfidjord från Mälardalen avviker från leratrots att den i vissa avseenden liknar sulfidjord från Norrbotniabanan. Sulfidjord från Spångadalenbör inte ens benämnas som sulfidjord då sulfidhalten var för låg, vilket upptäcktes under projektet.Den bör istället benämnas som lera med inslag av sulfid. Sulfidjord från Mälardalen bör därför ävenfortsatt utvärderas som lera. Dock behövs fortsatt forskning inom ämnet behövs för att säkerställadenna slutsats.
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Saxin, Jonathan. "Jämförelse av Polar Vantage V ”Konditionstest” med direkt mätning av VO2max." Thesis, Linnéuniversitetet, Institutionen för idrottsvetenskap (ID), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-104215.
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Bakgrund: Det finns flertalet modeller av pulsklockor på marknaden med funktioner som skall kunna uppskatta individens maximala syreupptagningsförmåga. En av dessa modeller är Polar Vantage V, som enligt tillverkaren kan uppskatta individens VO2max genom funktionen”konditionstest”. Testet utförs genom ett fem minuters vilotest. Testvärdet beräknas sedan från hjärtfrekvens samt personliga faktorer. Syfte: Studien jämförde Polar Vantage V uppskattade testvärde med en direkt mätning av VO2max, med frågeställningen om detta test var pålitligt och användbart i praktiken. Metod: En experimentell studiedesign användes som inkluderade 11 män samt 5 kvinnor som deltagare (N=16). Alla deltagare utförde Polar Vantage V’s konditionstest i vila, för att sedan utföra en maximal prestation utfört på löpband. För mätning av VO2max användes ergospirometri-systemet Jaeger®Vyntus CPX med halvmask. Resultat:Kendall Tau-b test visade signifikant starkt positivt samband mellan Vantage V’s testvärde och VO2max från Vyntus CPX. Wilcoxon Signed Rank test visade ingen signifikant skillnad mellan testvärdet (grupp medelvärde) från Vantage V och Vyntus CPX. Slutsats: På grund av stora individuella skillnader i testvärdet mätt med ”Konditionstestet” från Vantage V, bör individen tolka resultatet med aktsamhet. Vantage V’s ”Konditionstest” verkar emellertid kunna ge en bra uppskattning av VO2max på gruppnivå för friska vuxna i 20-36 års ålder.<br>Background: There are several models of fitness devices on the market with functions that claims to have the capability to estimate the capacity of a individuals maximum oxygen uptake. One of these models is the Polar Vantage V fitness watch, which according to the manufacturer can estimate the VO2max through the function "Fitness test". The test is performed through a five-minute rest test. The test result is then calculated thru various variables such as the individuals resting heart rate and personal factors. Purpose: To assess the estimated test value of the Polar Vantage V “Fitness test” with a direct measurement of VO2max, with the research question whether this test was valid and useful in practice. Method: This study used an experimental design and included 11 men and 5 women as participants (N = 16). All participantsfirst performed the Polar Vantage V's “Fitness test”, then proceeded to perform a maximum performance using a treadmill. For measurement of VO2max, the cardiopulmonary exercisetesting system Jaeger®Vyntus CPX with half mask was used. Results: Kendall Tau-b test presented a significant strong positive relationship between Vantage V’s “Fitness test” and VO2max -value from the Vyntus CPX. The Wilcoxon Signed Rank test presented a nonsignificant difference between the test value (group mean value) from Vantage V “Fitness test”and VO2max from Vyntus CPX. Conclusion: Due to large individual differences in the test value measured by the "Fitness test" from Vantage V, one should interpret the test-result with care. However, the Vantage V "Fitness test" seems to be able to provide a good estimate of theVO2max at group level in healthy adults aged between 20-36.
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Di, Filippi Arturo. "Development and experimental validation of CPOx reforming dynamic model for fault detection and isolation in SOFC systems." Doctoral thesis, Universita degli studi di Salerno, 2015. http://hdl.handle.net/10556/1932.
Full textAbstract:
2013 - 2014<br>In the present work an investigation of the reforming technologies available for Solid Oxide Fuel Cell (SOFC) systems and their basic concepts has been carried out, with the aim to describe, test and simulate the reforming process for fault diagnosis application.
The final aim of a fault diagnosis activity for SOFC systems is to reach the required criteria for a commercial application, which, besides long lifetime and performance, include high reliability and safety at reasonable costs. The achievement of these targets is necessary to contribute promoting the SOFC technology and finally starting a mass production phase.
In this thesis, the attention has been focused on the reforming reactor, responsible for the conversion of the inlet fuel in hydrogen, suitable source fuel for the SOFC. In particular, the Catalytic Partial Oxidation (CPOx) process has been analyzed.
The CPOx reforming mechanism is the most attractive technology for the production of syngas or hydrogen in small-medium scale SOFC applications and Micro Combined Heat and Power (μCHP) systems. This is due to the ability of the CPOx reaction to be carried out in compact reactors with rapid dynamic response and with low heat capacity. The reaction is slightly exothermic and therefore does not require external heat to take place. In addition, CPOx technology does not require steam, as the media required for the reforming reaction is air, which is easily available for residential application. This mainly means that CPOx is independent from an external water source and any heating source. The hydrocarbon is both oxidized to CO2 and H2O, either partially or completely, and also converted to synthesis gas by endothermic steam reforming (according to the indirect CPOx mechanism).
Despite these advantages, catalytic partial oxidation is less efficient than steam reforming. This indicates that it is most suitable for applications in which the system simplicity has the priority with respect to the hydrogen yield. The high surface temperatures can cause a local loss of activity of the catalyst, leading to the instable performance of the entire reactor. Nevertheless, in the CPOx process even a small difference in the operating air and fuel flow rates could lead to carbon deposition or oxidation of the catalyst, with serious consequences for the SOFC system and for the stack itself.
It is therefore extremely important to develop a diagnosis tool able to investigate these phenomena and to detect and isolate the faults that may verify inside the reactor. The most common fault events likely to occur inside a CPOx reformer for SOFC applications have been analyzed through a Failure Mode and Effect Analysis (FMEA) and a Fault Tree Analysis (FTA). These analyses are aimed at identifying the main events responsible for the catalyst deactivation, together with their causes and effects on the SOFC system performance.
The Catalytic Partial Oxidation mechanism has then been explored from both modelling and experimental points of view, with the aim to simulate the reforming process and identifying the thermodynamic optimal operating conditions at which natural gas may be converted to hydrogen. At the same time, the main fault scenarios likely to occur during the reforming phase have been analyzed, both in experiments and during simulations, to evaluate the capability of the developed model in performing effective fault detection and isolation for on-board diagnostic application.
The CPOx dynamic model developed is based on the minimization of Gibbs free energy and can be easily reconfigured for describing a steam reforming mechanism. The simulation results give useful indication on how operating parameters such as the input conditions of reactants (inlet compositions
and temperature) affect the reaction equilibrium and, in turn, the products composition and reactor outlet temperature. A sensitivity analysis for different operating conditions has been carried out. The transient behavior of the reforming reaction and the information about methane conversion and hydrogen selectivity complete the set of model results.
The dynamic CPOx model has been validated through experimental data and its behavior during transients has been carefully analyzed during the variations in the set-points of operating phases. Both test data and reactor design were part of the activities performed within the EFESO project, funded by the Italian Ministry of Economic Development and led by Ariston Thermo Spa.
The model results demonstrate that the CPOx dynamic model represents a useful tool for fault diagnosis application and its results provide an interesting benchmark for the design and working parameters of a CPOx reforming system for SOFC application. [edited by author]<br>XIII n.s.