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1

GENÇ, Tülay TURGUT, Ataberk ÇAKAN, and Melih GÜNAY. "CRABTREE POZİTİF VE CRABTREE NEGATİF MAYA TÜRLERİNDE GCR1 GENİNİN IN SILICO ANALİZİ." Euroasia Journal of Mathematics, Engineering, Natural & Medical Sciences 8, no. 17 (2021): 207–16. http://dx.doi.org/10.38065/euroasiaorg.698.

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The use of fermentation in the presence of oxygen and at high glucose concentrations is referred to as the Crabtree effect. Yeast species that have the Crabtree effect are called Crabtree positive, and yeast species that do not have the Crabtree effect are called Crabtree negative. While Crabtree negative yeast strains are mostly used for heterologous protein production in the industrial field, Crabtree positive yeast strains are used to understand metabolic events in cancer cells. The genes encoding the enzymes involved in the glycolytic pathway in S. cerevisiae yeast cells are controlled by
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2

Taz, Humaira. "George Crabtree." MRS Bulletin 44, no. 06 (2019): 509. http://dx.doi.org/10.1557/mrs.2019.144.

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3

Van Urk, H., E. Postma, W. A. Scheffers, and J. P. Van Dijken. "Glucose Transport in Crabtree-positive and Crabtree-negative Yeasts." Microbiology 135, no. 9 (1989): 2399–406. http://dx.doi.org/10.1099/00221287-135-9-2399.

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Suntara, Chanon, Anusorn Cherdthong, Suthipong Uriyapongson, Metha Wanapat, and Pin Chanjula. "Comparison Effects of Ruminal Crabtree-Negative Yeasts and Crabtree-Positive Yeasts for Improving Ensiled Rice Straw Quality and Ruminal Digestion Using In Vitro Gas Production." Journal of Fungi 6, no. 3 (2020): 109. http://dx.doi.org/10.3390/jof6030109.

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The objective of this study was to compare the effects of Crabtree-negative ruminal yeast and Crabtree-positive yeast in ensiled rice straw (RS) on the ensilage quality, nutritive value, and microorganism composition, including the evaluation of the ensiled RS using the in vitro gas production technique. The experiment was conducted in a 4 × 3 factorial arrangement in a randomized complete design. Factor A was yeast species with no inoculant, Crabtree-negative yeasts (Pichia kudriavzevii KKU20 and Candida tropicalis KKU20), and Crabtree-positive yeast (Saccharomyces cerevisae), whereas factor
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5

Grosso, Michael. "Interview with Adam Crabtree." Philosophical Practice: Journal of the American Philosophical Practitioners Association 2, no. 2 (2006): 119–23. http://dx.doi.org/10.1080/17428170601095473.

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6

Suntara, Chanon, Metha Wanapat, Sompong Chankaew, et al. "Improvement of the Nutritional Quality of Psophocarpus tetragonolobus Tubers by Fermentation with Ruminal Crabtree-Negative Yeasts on the In Vitro Digestibility and Fermentation in Rumen Fluid." Fermentation 8, no. 5 (2022): 209. http://dx.doi.org/10.3390/fermentation8050209.

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The purpose of this study was to determine how ruminal Crabtree-negative yeast affects the nutritional characteristics of winged bean (Psophocarpus tetragonolobus) tubers (WBT), in vitro gas and digestibility, and rumen fermentation. The experiment was carried out in a randomized complete design with a 5 × 2 (+1) factorial arrangement. Factor A determined the WBT products (a1 = dry WBT, a2 = fermented WBT without yeast in media solution, a3 = fermented WBT with Pichia kudriavzevii KKU20, a4 = fermented WBT with Candida tropicalis KKU20, and a5 = fermented WBT with Saccharomyces cerevisiae), wh
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7

Redman, Emily K., Paul S. Brookes, and Marcin K. Karcz. "Role of p90RSK in regulating the Crabtree effect: implications for cancer." Biochemical Society Transactions 41, no. 1 (2013): 124–26. http://dx.doi.org/10.1042/bst20120277.

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High glucose inhibits mitochondrial respiration, known as the ‘Crabtree effect’, in cancer cells and possibly other cell types. The upstream pathways regulating this phenomenon are poorly understood. In diabetes, where glucose levels are elevated, the p90RSK (p90 ribosomal S6 kinase) has received much attention as a potential upstream mediator of the effects of high glucose. Evidence is also emerging that p90RSK may play a role in cancer cell signalling, although the role of p90RSK in regulating cancer cell metabolism is unclear. In the present paper, we provide an overview of the Crabtree eff
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8

Van Urk, Hendrik, W. S. Leopold Voll, W. Alexander Scheffers, and Johannes P. Van Dijken. "Transient-State Analysis of Metabolic Fluxes in Crabtree-Positive and Crabtree-Negative Yeasts." Applied and Environmental Microbiology 56, no. 1 (1990): 281–87. http://dx.doi.org/10.1128/aem.56.1.281-287.1990.

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9

Seidler, G. T., T. F. Rosenbaum, and G. W. Crabtree. "Seidler, Rosenbaum, and Crabtree, Reply:." Physical Review Letters 73, no. 16 (1994): 2276. http://dx.doi.org/10.1103/physrevlett.73.2276.

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10

Crabtree, B., and E. A. Newsholme. "Reply from crabtree and newsholme." Trends in Biochemical Sciences 10, no. 10 (1985): 387. http://dx.doi.org/10.1016/0968-0004(85)90064-7.

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11

Crabtree, B., and E. A. Newsholme. "Reply from Crabtree and Newsholme." Trends in Biochemical Sciences 12 (January 1987): 224. http://dx.doi.org/10.1016/0968-0004(87)90113-7.

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12

Kumar, Abhay, Jaswandi Ujwal Dandekar, and Paike Jayadeva Bhat. "Fermentative metabolism impedes p53-dependent apoptosis in a Crabtree-positive but not in Crabtree-negative yeast." Journal of Biosciences 42, no. 4 (2017): 585–601. http://dx.doi.org/10.1007/s12038-017-9717-2.

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13

Crabtree, James. "Timing of artificial insemination in relation to ovulation." Equine Health 2020, no. 51 (2020): 26–28. http://dx.doi.org/10.12968/eqhe.2020.51.26.

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14

Castro Silva, Julissa. "CRABTREE, John y DURAND, Francisco. (2017). Perú:." CUPEA Cuadernos de Política Exterior Argentina, no. 129 (May 21, 2020): 103–6. http://dx.doi.org/10.35305/cc.vi129.20.

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Reseña del libro:CRABTREE, John y DURAND, Francisco. (2017). Perú: élites del poder y captura política, Red para el Desarrollo de las Ciencias Sociales en el Perú, Lima. ISBN: 978-997-283-522-3, 202 páginas
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15

Crabtree, Jack, and Christopher Coppock. "Jack Crabtree in Conversation with Christopher Coppock." Circa, no. 25 (1985): 14. http://dx.doi.org/10.2307/25557012.

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16

Sokolov, S. S., O. V. Markova, K. D. Nikolaeva, I. A. Fedorov, and F. F. Severin. "Triosephosphates as intermediates of the Crabtree effect." Biochemistry (Moscow) 82, no. 4 (2017): 458–64. http://dx.doi.org/10.1134/s0006297917040071.

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17

Burgess, K., and J. Zhou. "Diastereoselective Hydrogenation Using Chiral Crabtree-Type Catalysts." Synfacts 2007, no. 5 (2007): 0515. http://dx.doi.org/10.1055/s-2007-968457.

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18

Sener, A., F. Blachier, and W. J. Malaisse. "Crabtree effect in tumoral pancreatic islet cells." Journal of Biological Chemistry 263, no. 4 (1988): 1904–9. http://dx.doi.org/10.1016/s0021-9258(19)77963-0.

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19

Lee, Adrian, Hazel Mitchell, and Jani O'Rourke. "Response to Letter by Crabtree et al." Helicobacter 7, no. 2 (2002): 140–41. http://dx.doi.org/10.1046/j.1083-4389.2002.00072.x.

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20

Somjee, Shehnaz. "The Somjee-Crabtree temporal bone support clamp." Journal of Laryngology & Otology 111, no. 1 (1997): 54–55. http://dx.doi.org/10.1017/s0022215100136412.

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AbstractA new device is introduced for holding temporal bones during dissection. It is structurally very different, more practical and effective for securing the bone than the temporal bone holding bowl which has been in use so far.
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21

Bao, Wei-Guo, Bernard Guiard, Zi-An Fang, et al. "Oxygen-Dependent Transcriptional Regulator Hap1p Limits Glucose Uptake by Repressing the Expression of the Major Glucose Transporter Gene RAG1 in Kluyveromyces lactis." Eukaryotic Cell 7, no. 11 (2008): 1895–905. http://dx.doi.org/10.1128/ec.00018-08.

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ABSTRACT The HAP1 (CYP1) gene product of Saccharomyces cerevisiae is known to regulate the transcription of many genes in response to oxygen availability. This response varies according to yeast species, probably reflecting the specific nature of their oxidative metabolism. It is suspected that a difference in the interaction of Hap1p with its target genes may explain some of the species-related variation in oxygen responses. As opposed to the fermentative S. cerevisiae, Kluyveromyces lactis is an aerobic yeast species which shows different oxygen responses. We examined the role of the HAP1-eq
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22

Rothman, Douglas L., Stephen C. Stearns, and Robert G. Shulman. "Gene expression regulates metabolite homeostasis during the Crabtree effect: Implications for the adaptation and evolution of Metabolism." Proceedings of the National Academy of Sciences 118, no. 2 (2020): e2014013118. http://dx.doi.org/10.1073/pnas.2014013118.

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A key issue in both molecular and evolutionary biology has been to define the roles of genes and phenotypes in the adaptation of organisms to environmental changes. The dominant view has been that an organism’s metabolic adaptations are driven by gene expression and that gene mutations, independent of the starting phenotype, are responsible for the evolution of new metabolic phenotypes. We propose an alternate hypothesis, in which the phenotype and genotype together determine metabolic adaptation both in the lifetime of the organism and in the evolutionary selection of adaptive metabolic trait
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23

Paul, Lissa. "Niche Marketing and the (Shallow) World of Crabtree." Jeunesse: Young People, Texts, Cultures 1, no. 1 (2009): 169–83. http://dx.doi.org/10.3138/jeunesse.1.1.169.

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24

Lissa Paul. "Niche Marketing and the (Shallow) World of Crabtree." Jeunesse: Young People, Texts, Cultures 1, no. 1 (2010): 169–83. http://dx.doi.org/10.1353/jeu.2010.0013.

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25

Chapman, Allan. "Horrocks, Crabtree and the 1639 transit of Venus." Astronomy and Geophysics 45, no. 5 (2004): 5.26–5.31. http://dx.doi.org/10.1046/j.1468-4004.2003.45526.x.

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26

Melo, Roberto F., Fabíola R. Stevan, Annibal P. Campello, Eva G. S. Carnieri, and Maria Benigna Martinelli De Oliveira. "Occurrence of the Crabtree effect in HeLa cells." Cell Biochemistry and Function 16, no. 2 (1998): 99–105. http://dx.doi.org/10.1002/(sici)1099-0844(199806)16:2<99::aid-cbf773>3.0.co;2-2.

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27

Habegger, Loïc, Kelly Rodrigues Crespo, and Michal Dabros. "Preventing Overflow Metabolism in Crabtree-Positive Microorganisms through On-Line Monitoring and Control of Fed-Batch Fermentations." Fermentation 4, no. 3 (2018): 79. http://dx.doi.org/10.3390/fermentation4030079.

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At specific growth rates above a particular critical value, Crabtree-positive microorganisms exceed their respiratory capacity and enter diauxic growth metabolism. Excess substrate is converted reductively to an overflow metabolite, resulting in decreased biomass yield and productivity. To prevent this scenario, the cells can be cultivated in a fed-batch mode at a growth rate maintained below the critical value, µcrit. This approach entails two major challenges: accurately estimating the current specific growth rate and controlling it successfully over the course of the fermentation. In this w
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28

Souto-Maior, Ana Maria, David Runquist, and Bärbel Hahn-Hägerdal. "Crabtree-negative characteristics of recombinant xylose-utilizing Saccharomyces cerevisiae." Journal of Biotechnology 143, no. 2 (2009): 119–23. http://dx.doi.org/10.1016/j.jbiotec.2009.06.022.

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29

Rizzi, Manfred, Michael Baltes, Werner Mailinger, Uwe Theobald, and Matthias Reuss. "Modelling of Short Term Crabtree-Effect in Baker's Yeast." IFAC Proceedings Volumes 28, no. 3 (1995): 124–29. http://dx.doi.org/10.1016/s1474-6670(17)45613-8.

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30

Neumann, Julia J, and Frank Glorius. "Green Catalysis.1-3. Edited by Robert H. Crabtree." Angewandte Chemie International Edition 48, no. 39 (2009): 7120–21. http://dx.doi.org/10.1002/anie.200903584.

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31

Gibart, Laetitia, Rajeev Khoodeeram, Gilles Bernot, Jean-Paul Comet, and Jean-Yves Trosset. "Regulation of Eukaryote Metabolism: An Abstract Model Explaining the Warburg/Crabtree Effect." Processes 9, no. 9 (2021): 1496. http://dx.doi.org/10.3390/pr9091496.

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Adaptation of metabolism is a response of many eukaryotic cells to nutrient heterogeneity in the cell microenvironment. One of these adaptations is the shift from respiratory to fermentative metabolism, also called the Warburg/Crabtree effect. It is a response to a very high nutrient increase in the cell microenvironment, even in the presence of oxygen. Understanding whether this metabolic transition can result from basic regulation signals between components of the central carbon metabolism are the the core question of this work. We use an extension of the René Thomas modeling framework for r
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32

Kasperski, Andrzej. "Life Entrapped in a Network of Atavistic Attractors: How to Find a Rescue." International Journal of Molecular Sciences 23, no. 7 (2022): 4017. http://dx.doi.org/10.3390/ijms23074017.

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In view of unified cell bioenergetics, cell bioenergetic problems related to cell overenergization can cause excessive disturbances in current cell fate and, as a result, lead to a change of cell-fate. At the onset of the problem, cell overenergization of multicellular organisms (especially overenergization of mitochondria) is solved inter alia by activation and then stimulation of the reversible Crabtree effect by cells. Unfortunately, this apparently good solution can also lead to a much bigger problem when, despite the activation of the Crabtree effect, cell overenergization persists for a
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33

de Kok, Michèle J. C., Alexander F. Schaapherder, Rob C. I. Wüst, et al. "Circumventing the Crabtree effect in cell culture: A systematic review." Mitochondrion 59 (July 2021): 83–95. http://dx.doi.org/10.1016/j.mito.2021.03.014.

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34

Wojtczak, L. "The Crabtree effect: a new look at the old problem." Acta Biochimica Polonica 43, no. 2 (1996): 361–68. http://dx.doi.org/10.18388/abp.1996_4505.

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Inhibition of respiration by glucose, known as the Crabtree effect, has been observed in several tumours and some other highly glycolytic cells and tissues. Among mechanisms proposed to explain this effect were: competition between glycolysis and respiration for ADP or for inorganic phosphate, change of intracellular pH, change in the permeability of mitochondrial membranes, specific regulatory behavior of glycolytic enzymes, and specific enzyme topography within the cell. None of these proposals alone seems satisfactory. The present article describes the research carried out in the author's l
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35

Allan, Robin. "'Crabtree Var et Solidt Gærde1 -But Was it Really Cricket?" NOWELE Volume 21/22 (April 1993) 21-22 (April 1, 1993): 137–50. http://dx.doi.org/10.1075/nowele.21-22.11all.

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36

Kauffman, George B. "The Organometallic Chemisty of the Transition Metals (Crabtree, Robert H.)." Journal of Chemical Education 66, no. 3 (1989): A106. http://dx.doi.org/10.1021/ed066pa106.1.

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37

Rodríguez-Enríquez, Sara, Oscar Juárez, José S. Rodríguez-Zavala, and Rafael Moreno-Sánchez. "Multisite control of the Crabtree effect in ascites hepatoma cells." European Journal of Biochemistry 268, no. 8 (2001): 2512–19. http://dx.doi.org/10.1046/j.1432-1327.2001.02140.x.

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38

Bauer, Christopher. "Bolivia: Processes of Change - by Crabtree, John and Chaplin, Ann." Bulletin of Latin American Research 34, no. 3 (2015): 388–89. http://dx.doi.org/10.1111/blar.12332.

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39

Lozada, María Cecilia. "Bradley J. Adams, Pamela J. Crabtree (eds): Comparative Skeletal Anatomy." International Journal of Primatology 29, no. 4 (2008): 1117–18. http://dx.doi.org/10.1007/s10764-008-9274-5.

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40

Villadsen, John, and Sten Bay Jørgensen. "Reflections on the aerobic fermentation stoichiometry of crabtree positive yeasts." Biotechnology and Bioengineering 111, no. 3 (2013): 632–37. http://dx.doi.org/10.1002/bit.25110.

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41

Crabtree, B., G. Collins, and M. I. Franklin. "A simplified method for calculating complex metabolic sensitivities by using matrix partitioning." Biochemical Journal 263, no. 1 (1989): 289–92. http://dx.doi.org/10.1042/bj2630289.

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The matrix method for calculating the overall sensitivities (including control coefficients) of a metabolic system, described by Crabtree &amp; Newsholme [Biochem. J. 247, 113-129 (1987)], is simplified by a preliminary partitioning of the initial matrix equation. This reduces the size of the matrix to be inverted and thereby removes a major drawback with the original method. The resulting procedure is simpler and more systematic than the alternative methods currently available, especially when the system is extensively branched.
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42

Qi, Kai, Jian-Jiang Zhong, and Xiao-Xia Xia. "Triggering Respirofermentative Metabolism in the Crabtree-Negative Yeast Pichia guilliermondii by Disrupting theCAT8Gene." Applied and Environmental Microbiology 80, no. 13 (2014): 3879–87. http://dx.doi.org/10.1128/aem.00854-14.

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ABSTRACTPichia guilliermondiiis a Crabtree-negative yeast that does not normally exhibit respirofermentative metabolism under aerobic conditions, and methods to trigger this metabolism may have applications for physiological study and industrial applications. In the present study,CAT8, which encodes a putative global transcriptional activator, was disrupted inP. guilliermondii. This yeast's ethanol titer increased by &gt;20-fold compared to the wild type (WT) during aerobic fermentation using glucose. A comparative transcriptional analysis indicated that the expression of genes in the tricarbo
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43

Crabtree, B. "A method for identifying external control sites in metabolic systems." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 262, no. 5 (1992): R806—R812. http://dx.doi.org/10.1152/ajpregu.1992.262.5.r806.

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A graphic method is presented for the identification of control sites in a metabolic system. This method is based on the matrix method for calculating net sensitivities developed by Crabtree and Newsholme (Biochem. J. 247: 113-120, 1987) and avoids the misidentification of control sites that can result from a simple inspection of a system. The method is easily adapted for analysis by computer and may be used for preliminary investigations of metabolic systems to identify potential control sites for further more quantitative investigations.
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44

Hamraz, Minoo, Raymond Abolhassani, Mireille Andriamihaja, et al. "Hypertonic external medium represses cellular respiration and promotes Warburg/Crabtree effect." FASEB Journal 34, no. 1 (2019): 222–36. http://dx.doi.org/10.1096/fj.201900706rr.

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45

Hagman, Arne, Torbjörn Säll, and Jure Piškur. "Analysis of the yeast short‐term Crabtree effect and its origin." FEBS Journal 281, no. 21 (2014): 4805–14. http://dx.doi.org/10.1111/febs.13019.

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Díaz-Ruiz, Rodrigo, Nicole Avéret, Anne Devin, Salvador Uribe, and Michel Rigoulet. "S8.20 The mechanisms leading to the Crabtree effect in fermenting yeast." Biochimica et Biophysica Acta (BBA) - Bioenergetics 1777 (July 2008): S52. http://dx.doi.org/10.1016/j.bbabio.2008.05.207.

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47

González Siso, M. I., E. Ramil, M. E. Cerdán, and M. A. Freire-Picos. "Respirofermentative metabolism in Kluyveromyces lactis: Ethanol production and the Crabtree effect." Enzyme and Microbial Technology 18, no. 8 (1996): 585–91. http://dx.doi.org/10.1016/0141-0229(95)00151-4.

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48

Osawa, Fumi, Toshio Fujii, Takehisa Nishida, et al. "Efficient production of L-lactic acid by Crabtree-negative yeastCandida boidinii." Yeast 26, no. 9 (2009): 485–96. http://dx.doi.org/10.1002/yea.1702.

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49

Cunha Filho, Clayton Mendonça. "The "Proceso de Cambio" a Decade Later: What is New in the New Bolivia?" Bolivian Studies Journal/Revista de Estudios Bolivianos 21 (March 17, 2016): 234–45. http://dx.doi.org/10.5195/bsj.2015.147.

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CRABTREE, John; CHAPLIN, Ann. Bolivia: procesos de cambio. La Paz: Oxfam/Cedla/Fundación PIEB, 2013. ESPINOZA, Fran. Bolivia: La circulación de sus élites (2006-2014). Santa Cruz de la Sierra: El País, 2014. (Colección Ciencias Sociales e Historia de El País, 36). SORUCO SOLOGUREN, Ximena; FRANCO PINTO, Daniela; DURÁN AZURDUY, Mariela (Org.). Composición social del Estado plurinacional: hacia la descolonización de la burocracia. 1. ed. La Paz: CIS, 2014. ZEGADA, María Teresa; KOMADINA, Jorge. El espejo de la sociedad: poder y representación en Bolivia. La Paz: Plural Editores, 2014. (Bibliotec
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50

Agrimi, Gennaro, Luca Brambilla, Gianni Frascotti, et al. "Deletion or Overexpression of Mitochondrial NAD+Carriers inSaccharomyces cerevisiaeAlters Cellular NAD and ATP Contents and Affects Mitochondrial Metabolism and the Rate of Glycolysis." Applied and Environmental Microbiology 77, no. 7 (2011): 2239–46. http://dx.doi.org/10.1128/aem.01703-10.

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ABSTRACTThe modification of enzyme cofactor concentrations can be used as a method for both studying and engineering metabolism. We variedSaccharomyces cerevisiaemitochondrial NAD levels by altering expression of its specific mitochondrial carriers. Changes in mitochondrial NAD levels affected the overall cellular concentration of this coenzyme and the cellular metabolism. In batch culture, a strain with a severe NAD depletion in mitochondria succeeded in growing, albeit at a low rate, on fully respiratory media. Although the strain increased the efficiency of its oxidative phosphorylation, th
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