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Journal articles on the topic 'Crataegus extract'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Kurkin, Vladmir A., Nadezhda A. Volkova, Olga E. Pravdivtseva, Elena N. Zaitceva, Anastasiya S. Tsibina, and Anastasiya I. Klimova. "The effect of thick hawthorn extracts on kidney." Science and Innovations in Medicine 7, no. 3 (2022): 202–5. http://dx.doi.org/10.35693/2500-1388-2022-7-3-202-205.

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Aim to study the effect of the hawthorn shoots on kidney excretory function. Material and methods. We used the shoots of Crataegus sanguinea Pall., Crataegus monogina Jacq. and Crataegus submollis Sarg. harvested during the flowering period in the arboretum of the Botanical Garden of Samara University in 2021. The raw material of each type, separately, was used in fractional maceration with 70% ethyl alcohol for creation liquid extracts, then, after extractant removal, the thick extracts were obtained. The thick extracts were processed with differential spectrophotometry method to calcul

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Mohammed, Mustafa T. "Biochemical studies on the effect of Crataegus aqueous extract on oxidative stress during ischemia/reperfusion induced myocardial injuries." Journal of the Faculty of Medicine Baghdad 57, no. 3 (2015): 248–53. http://dx.doi.org/10.32007/jfacmedbagdad.573374.

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Background: myocardial ischemia-reperfusion (I/R) injury may occur in a variety of clinical settings and this remains a significant problem. Oxygen free radicals, produced on reperfusion have been shown to play a major role in myocardial I/R injury. Various therapeutic effects have been described for Crataegus. Additionally, it has been presented that Crataegus has protective effect against ischemia reperfusion induced myocardial injuries to various organs. Therefore, it seems possible that the administration of Crataegus might protect the heart against the ischemia reperfusion injury.Objectiv

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Schlegelmilch, Ronald, and Ralph Heywood. "Toxicity of Crataegus (Hawthorn) Extract (WS 1442)." Journal of the American College of Toxicology 13, no. 2 (1994): 103–11. http://dx.doi.org/10.3109/10915819409140991.

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An extract of Crataegus-WS 1442-standardized by a special process of production and adjusted to 18.75% oligomeric procyanidines, was investigated in single and repeat-dose toxicity studies. No target organ toxicity was defined at high multiples of the human dose (100 times) and the battery of standard mutagenic and clastogenic tests were negative. The results presented are for Crataegus extract WS 1442 only; other preparations of Crataegus have to be investigated case by case.

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Shaikhutdinov, Ilnur Kh, Tatyana V. Morozova, Vladimir A. Kurkin, et al. "Pharmacognostic and pharmacological study of liquid extract of Crataegus Submollis Sarg. Flowers." Aspirantskiy Vestnik Povolzhiya 19, no. 5-6 (2020): 160–64. http://dx.doi.org/10.17816/2072-2354.2019.19.3.160-164.

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The flowers and fruits of various species of the hawthorn genus (Crataegus L.) are widely used in domestic and foreign medical practice as cardiotonic agents. A perspective species for collecting of the raw material is Crataegus submollis Sarg. It was determined that 70% ethanol is an optimal extragent for the extraction of flavonoids from Crataegus submollis Sarg. flowers. The content of the total flavonoids in terms of hyperoside in the liquid extract of Crataegus submollis Sarg. flowers is 0,24 0,01%. It was established that liquid extract of Crataegus submollis Sarg. with using of 70% etha

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Kurkin, V. A., E. N. Zaitceva, T. V. Morozova, et al. "The study of the Crataegus sanguinea Pall. extractsdiuretic and antidepressant action." Bulletin of Siberian Medicine 17, no. 4 (2018): 65–71. http://dx.doi.org/10.20538/1682-0363-2018-4-65-71.

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The purposeof the study is to study the urinative and antidepressant activities of liquid extracts based on flowers, shoots, leaves and fruits ofCrataegus sanguineaPall. to substantiate their use in the development and manufacture of drugs for the complex treatment of cardiovascular diseases.Materials and methods.The comparative study of the diuretic and antidepressant activity of liquid extracts based on leaves, flowers, shoots and fruits Crataegus sanguinea was conducted. The liquid extracts were obtained on the basis of dried leaves, flowers, shoots and fruits of Crataegus sanguinea. All li

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Inomjonov, Dolimjon, Izzatullo Abdullaev, Sirojiddin Omonturdiev, et al. "In Vitro and In Vivo Studies of Crategus and Inula helenium extracts: Their Effects on Rat Blood Pressure." Trends in Sciences 22, no. 3 (2025): 9158. https://doi.org/10.48048/tis.2025.9158.

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The contraction of aortic tissues induced by 50 mM KCl is primarily mediated through the activation of voltage-dependent L-type Ca2+ channels in smooth muscle cells. In this study, the effects of Crategus Rosaceae and Inula helenium extracts on KCl-induced contraction were investigated. Extracts of Crataegus attenuated the KCl-induced contraction by 15.0 ± 2.6 and 70.0 ± 2.8 % at concentrations ranging from 20 - 70 μg/mL, while Inula helenium extract reduced the contraction by 5.0 ± 3.1 and 80.0 ± 2.8 % at concentrations of 10 - 50 μg/mL. These findings suggest that the extracts inhibit KCl-in

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Bernatonienė, Jurga, Rūta Masteikova, Daiva Majienė, et al. "Free radical-scavenging activities of Crataegus monogyna extracts." Medicina 44, no. 9 (2008): 706. http://dx.doi.org/10.3390/medicina44090091.

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The aim of this study was to investigate antiradical activity of aqueous and ethanolic hawthorn fruit extracts, their flavonoids, and flavonoid combinations. Material and methods. Total amount of phenolic compounds and the constituents of flavonoids were determined using a high-performance liquid chromatography. The antioxidant activity of Crataegus monogyna extracts and flavonoids (chlorogenic acid, hyperoside, rutin, quercetin, vitexin-2O-rhamnoside, epicatechin, catechin, and procyanidin B2) quantitatively was determined using the method of spectrophotometry (diphenyl-1-picrylhydrazyl (DPPH

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Kurkin, V. A., E. N. Zaitceva, O. E. Pravdivtseva, A. V. Kurkina, and V. V. Stenyaeva. "Fruits of Crataegus submollis: study of pharmacological activity of the preparations." Science and Innovations in Medicine 4, no. 3 (2019): 69–72. http://dx.doi.org/10.35693/2500-1388-2019-4-3-69-72.

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Objectives - to perform a comparative study of the antidepressant action and diuretic activity of liquid extract and decoction of the fruits of Crataegus submollis Sarg. Material and methods. The study of the antidepressant activity was performed using the behavioral despair test. The diuretic activity of the liquid extract and decoction from the Crataegus submollis fruits at a dose of 100 pl/kg was evaluated in long-term experiments. Results. The study revealed the impact of the liquid extract of Crataegus submollis fruits, at a dose of 100 pl/kg, on the motion activity of animals: it increas

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Rahhal, Belal, Isra Taha, Insaf Najajreh, et al. "Phytochemical Screening and Diuretic Activity of selected Palestinian Medicinal plants in Mice using an Aqueous Extract Division of Physiology, Pharmacology and Toxicology." Jordan Journal of Pharmaceutical Sciences 16, no. 2 (2023): 467. http://dx.doi.org/10.35516/jjps.v16i2.1510.

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Purpose: Man used various natural materials as a remedy for the treatment of various diseases and recently witnessed a vastly growing and renewed interest in herbal medicine globally. In Palestinian folk medicine, Crataegus aronia, Rosmarinus officinalis known as rosemary and Nigella sativa is used as a diuretic and for treatment of hypertension. This study aimed to assess the preliminary phytochemical properties and the diuretic effect of the aqueous extracts of these plants in mice after its intraperitonial administration. Methods: It is an experimental trial applied on mice (n=8, Male

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Szymborska, Karolina, Rafał Frański, and Monika Beszterda-Buszczak. "Extraction with Acidified Methanol—An Easy and Effective Method of Methyl Chlorogenate Formation, as Studied by ESI-MS." Molecules 27, no. 21 (2022): 7543. http://dx.doi.org/10.3390/molecules27217543.

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Among the different Hawthorn species, Crataegus monogyna seems to be one of the most often used in herbal medicine, and is commercially available. The methanolic extract and the acidified methanol extract of an herbal medicinal product based on Crataegus monogyna inflorescences were analyzed by using high-pressure liquid chromatography/electrospray ionization mass spectrometry (HPLC/ESI-MS). On the basis of m/z of [M-H]− ions and characteristic fragmentation patterns, a number of polyphenolic compounds, namely flavonoids and chlorogenic acids, were identified. It was found that the contents of

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Sáenz, M. T., M. C. Ahumada, and M. D. García. "Extracts from Viscum and Crataegus are Cytotoxic against Larynx Cancer Cells." Zeitschrift für Naturforschung C 52, no. 1-2 (1997): 42–44. http://dx.doi.org/10.1515/znc-1997-1-207.

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Abstract The effects of hexanoic extracts of Viscum cruciatum Sieber parasitic on Crataegus monogyna Jacq. (I), Crataegus monogyna Jacq. parasitized with Viscum cruciatum Sieber (II), and Crataegus monogyna Jacq. non-parasitized (III), and of a triterpenes enriched fractions isolated from I, II and III (CFI, CFII, CFIII respectively), on the growth of HEp-2 cells have been evaluated. All the samples demonstrated significant cytotoxic activity against cultured HEp-2 cells, and all of them showed a stronger in vitro activity than 6-mercaptopurine solution used as a positive control. With the he

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Amina, Boudjada, Touil Ahmed, Bendif Hamdi, Bensouici Chawki, and Rhouati Salah. "PHYTOCHEMICAL CONSTITUENTS, PHENOLIC CONTENTS, AND ANTIOXIDANT ACTIVITY OF CRATAEGUS AZAROLUS EXTRACTS." Asian Journal of Pharmaceutical and Clinical Research 11, no. 4 (2018): 133. http://dx.doi.org/10.22159/ajpcr.2018.v11i4.23724.

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Objective: The aim of this study was the isolation and identification of secondary metabolites from Crataegus azarolus (L.) and the antioxidant evaluation of its extracts and compounds.Methods: The air-dried powdered parts of the plant were extracted with 70% methanol and fractionated by chloroform, ethyl acetate, and n-butanol. The n-butanol extract was separated using polyamide SC6 column and silica gel TLC. In addition, a fraction of silica gel column of the CHCl3 extract was analyzed by gas chromatography–mass spectrometer (GC–MS). The total phenolic and total flavonoid contents of CHCl3 a

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Kim, Hyun-Soo. "Whitening effect of Crataegus pinnatifida fruit extract." Korean journal of food science and technology 55, no. 6 (2023): 586–91. http://dx.doi.org/10.9721/kjfst.2023.55.6.586.

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Krawczyk, Urszula, and Gisella Petri. "HPLC Analysis of Procyanidins in Crataegus Extract." Archiv der Pharmazie 324, no. 2 (1991): 97–99. http://dx.doi.org/10.1002/ardp.19913240207.

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Zeouk, Ikrame, Mounyr Balouiri, and Khadija Bekhti. "Antistaphylococcal Activity and Phytochemical Analysis of Crude Extracts of Five Medicinal Plants Used in the Center of Morocco against Dermatitis." International Journal of Microbiology 2019 (November 4, 2019): 1–7. http://dx.doi.org/10.1155/2019/1803102.

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Novel drugs for methicillin-resistant Staphylococcus aureus (MRSA) hospital- and community-acquired infections are needed because of the emergence of resistance against antibiotics. In this study, methanolic and aqueous extracts of Berberis hispanica, Crataegus oxyacantha, Cistus salviifolius, Ephedra altissima, and Lavandula dentata selected from an ethnopharmacological study to treat skin infections in Sefrou city (Center of Morocco) were tested for their antistaphylococcal activity against strains often involved in cutaneous disorders: two methicillin-resistant Staphylococcus aureus strains

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Šavikin, Katarina P., Dijana B. Krstić-Milošević, Nebojša R. Menković, Ivana N. Beara, Zorica O. Mrkonjić, and Dejan S. Pljevljakušić. "Crataegus orientalis Leaves and Berries: Phenolic Profiles, Antioxidant and Anti-inflammatory Activity." Natural Product Communications 12, no. 2 (2017): 1934578X1701200. http://dx.doi.org/10.1177/1934578x1701200204.

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The present study was designed to define the phenolic content, antioxidant and anti-inflammatory activity of Crateagus orientalis Pall. ex M. Bieb., traditionally used by local people in southern parts of F.Y.R. Macedonia. The presence and content of 7 phenolics in ethanolic extracts of leaves and berries were studied using HPLC-DAD, where the most dominant compounds were hyperoside, isoquercitrin and chlorogenic acid. The leaf extract was more effective as a DPPH radical scavenger (IC50 = 29.7 μg/g) than the berry extract, as well as in the relative reducing power on Fe3+. Anti-inflammatory p

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Kuczkowiak, Ulrich. "Hydroxycinnamic Acid Derivatives Obtained from a Commercial Crataegus Extract and from Authentic Crataegus spp." Scientia Pharmaceutica 82, no. 4 (2014): 835–46. http://dx.doi.org/10.3797/scipharm.1404-02.

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Khasanova, Svetlana Rashitovna, Natal'ya Vladimirovna Kudashkina, Valeriya Andreyevna Gusakova, and Nadira Begim Kursanovna Jalalova. "COMPARATIVE ANALYSIS OF THE CHEMICAL COMPOSITION OF LIPOPHILIC FRACTIONS OF SHOOTS OF THREE SPECIES OF THE GENUS CRATAEGUS L." chemistry of plant raw material, no. 4 (December 14, 2021): 373–80. http://dx.doi.org/10.14258/jcprm.2021048804.

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The article presents research of the chemical composition of lipophilic fractions of shoots Crataegus sanguinea Pall. (Rosaceae), Crataegus submollis Sarg. (Rosaceae) and Crataegus almaatensis Pojark. (Rosaceae). Lipophilic extract is obtained from petroleum ether. The components of the lipophilic fraction were separated and identified by gas chromatography with mass spectrometry. 36 compounds were identified in lipophilic fractions: hydrocarbons, fatty acids, sugars, phenolic compounds, diterpenoids and sterols. Their presence may determine the pharmacological properties of hawthorn shoots. T

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Paun, Gabriela, Elena Neagu, Camelia Albu, Andreia Alecu, Ana-Maria Seciu-Grama, and Gabriel Lucian Radu. "Antioxidant and Antidiabetic Activity of Cornus mas L. and Crataegus monogyna Fruit Extracts." Molecules 29, no. 15 (2024): 3595. http://dx.doi.org/10.3390/molecules29153595.

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The present study evaluated three green extraction methods, accelerated solvent extraction (ASE), ultrasound-assisted extraction (UAE), and laser irradiation extraction (LE), for the polyphenolic compounds and vitamin C extraction of Cornus mas L. and Crataegus monogyna fruit extracts. The polyphenols and vitamin C of extracts were quantified using HPLC-DAD, and the total phenolic content, flavonoid content, antioxidant activity (DPPH and reducing power), and antidiabetic activity were also studied. The antidiabetic activity was examined by the inhibition of α-amylase and α-glucosidase, and in

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Chen, San-Yuan, Ru-Hsiou Teng, Meilin Wang, et al. "Rhodiolae Kirliowii Radix et Rhizoma and Crataegus pinnatifida Fructus Extracts Effectively Inhibit BK Virus and JC Virus Infection of Host Cells." Evidence-Based Complementary and Alternative Medicine 2017 (2017): 1–11. http://dx.doi.org/10.1155/2017/5620867.

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The human polyomaviruses BK (BKPyV) and JC (JCPyV) are ubiquitous pathogens long associated with severe disease in immunocompromised individuals. BKPyV causes polyomavirus-associated nephropathy and hemorrhagic cystitis, whereas JCPyV is the causative agent of the fatal demyelinating disease progressive multifocal leukoencephalopathy. No effective therapies targeting these viruses are currently available. The goal of this study was to identify Chinese medicinal herbs with antiviral activity against BKPyV and JCPyV. We screened extracts of Chinese medicinal herbs for the ability to inhibit hema

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Taneva, Ira, and Zlatin Zlatev. "ANTIOXIDANT ACTIVITY AND PHYSICOCHEMICAL PARAMETERS OF YOGURT ENRICHED WITH EXTRACTS OF RED HAWTHORN (CRATAEGUS MONOGYNA JACQ.) AND BLACK HAWTHORN (CRATAEGUS NIGRA WALDST & KIT.)." Scientific Study & Research. Chemistry & Chemical Engineering, Biotechnology, Food Industry 25, no. 3 (2024): 239–53. http://dx.doi.org/10.29081/chiba.2024.590.

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The aim of this study was to determine some physicochemical parameters and antioxidant activity of fermented milks enriched with extracts of red hawthorn (Crataegus monogyna Jacq.) and black hawthorn (Crataegus nigra Waldst & Kit.) Antioxidant activity and the content of total phenols of water extracts of both species of hawthorn - red and black - were analyzed. The effect of the inclusion of the extracts in amounts of 5, 10 and 15 % of both species of hawthorn on the physicochemical and antioxidant properties of the obtained yogurts was monitored. Yogurts with the addition of red hawthorn

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Attard, Everaldo, and Henrietta Attard. "The Potential Angiotensin-Converting Enzyme Inhibitory Activity of Oleanolic Acid in the Hydroethanolic Extract of Crataegus monogyna Jacq." Natural Product Communications 1, no. 5 (2006): 1934578X0600100. http://dx.doi.org/10.1177/1934578x0600100507.

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The hydroethanolic extract of Crataegus monogyna was studied for its chemical constitution and angiotensin-converting enzyme (ACE) inhibitory activity. The extract contained triterpenic acids, flavonoids and coumarins. The ACE inhibitory activity was studied using captropril, as a control drug, and oleanolic acid, as a constituent of the hydroethanolic extract and a member of the triterpenic acid group. The hydroethanolic extract and oleanolic acid showed higher IC50 values (335.00 μg/mL and 3.61 μM, respectively) in comparison to captopril (46.9 nM). However, these results indicate the anti-A

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Ikhsanov, Y. S., K. M. Kusainova, G. Y. Tasmagambetova, N. T. Andasova, and Y. A. Litvinenko. "AMINO ACID AND VITAMIN COMPOSITION OF CRATAEGUS ORIENTALIS PALL." SERIES CHEMISTRY AND TECHNOLOGY 2, no. 446 (2021): 149–54. http://dx.doi.org/10.32014/2021.2518-1491.40.

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The genus hawthorn (Crataegus) belongs to the apple subfamily (Maloideae Focke) of the Rosaceae Juss family. The hawthorn genus includes about 1500 species distributed in warm temperate and subtropical regions of the northern hemisphere, mainly in North America. Over 80 wild and 90 introduced species grow on the territory of the CIS. Kazakhstan belongs to the forest-deficient regions; the forest cover of the territory is 3.87%. The hawthorn, which grows in flat areas, at the foot of the mountains, in the mountains, in the steppe and forest-steppe, is quite common here, is part of the undergrow

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Żurek, Natalia, Olena Karatsai, Maria Jolanta Rędowicz, and Ireneusz Tomasz Kapusta. "Polyphenolic Compounds of Crataegus Berry, Leaf, and Flower Extracts Affect Viability and Invasive Potential of Human Glioblastoma Cells." Molecules 26, no. 9 (2021): 2656. http://dx.doi.org/10.3390/molecules26092656.

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Crataegus contains numerous health-promoting compounds that are also proposed to have anti-cancer properties. Herein, we aimed at a contemporaneous evaluation of the effects of polyphenol-rich extracts of berries, leaves, and flowers of six Crataegus species on the viability and invasive potential on the highly aggressive human glioblastoma U87MG cell line. The treatment with the extracts evoked cytotoxic effects, with the strongest in the berry extracts. All extracts not only promoted the apoptosis-related cleavage of poly (ADP-ribose) polymerase 1 (PARP1) but also substantially inhibited the

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Turnalar Ülger, Tansu, Mehmet Ali Oçkun, Etil Guzelmeric, et al. "Comprehensive Analysis of the Chemical and Bioactivity Profiles of Endemic Crataegus turcicus Dönmez in Comparison with Other Crataegus Species." Molecules 28, no. 18 (2023): 6520. http://dx.doi.org/10.3390/molecules28186520.

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Crataegus turcicus is a plant endemic to Türkiye. For the first time, this study aimed to comparatively assess its flower-bearing branches, leaves, and fruits with other well-known Crataegus species (C. monogyna, C. pentagyna, and C. orientalis) in terms of chemical composition and bioactivity studies to evaluate its potential use as a food supplement. Firstly, the contents of total phenolics (TPC), flavonoids (TFC), proanthocyanidin (TPAC), and anthocyanin (TAC) in different plant parts of Crataegus species were evaluated. The highest TPAC was found in the hydroalcoholic extract of C. turcicu

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Kukhtenko, O. S., N. Y. Bevz, Ie V. Gladukh, and H. P. Kukhtenko. "Study on the development of liquid extract of cardiotonic action." Farmatsevtychnyi zhurnal, no. 3 (July 1, 2019): 41–48. http://dx.doi.org/10.32352/0367-3057.3.19.05.

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At the Department of Industrial Pharmacy of the National University of Pharmacy, a complex cardiotonic action extract containing extracts of Crataegus охуaсanta fruits, Leonurus cardiaca herb, Melissa officinalis herb and Humulus lupulus seedballs in equals proportions is being developed. The purpose of work was to determine the quantitative yield of biologically active substances, depending on the degree of depletion of medicinal plant raw materials extractant. Each medicinal plant raw material used in obtaining the extract was tested for compliance with the incoming normative doc

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Ganie, Showkat Ahmad, Tanveer Ali Dar, Bilal Zargar, et al. "Antioxidant and Hepatoprotective Effects of Crataegus songarica Methanol Extract." Journal of Environmental Pathology, Toxicology and Oncology 33, no. 2 (2014): 131–43. http://dx.doi.org/10.1615/jenvironpatholtoxicoloncol.2014010606.

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Mihajlovic, Dusanka, Vesna Novkovic, and Vladimir Bankovic. "The determination of hyperoside in the flower and leaf of hawthorn (Crataegus oxycantha and Crataegus monogyna) by the spectrophotometric method." Chemical Industry 60, no. 3-4 (2006): 87–91. http://dx.doi.org/10.2298/hemind0604087m.

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The flower and leaf of hawthorn contains many active components, used in the production of pharmaceutical preparations for cardiotonic, anti-hypertonic anti-hypotonic, artherosclerotic, anti-arithmic and anti-anemic groups. According to the ROTTE list (1996), 159 of 1800 pharmaceutical preparations contain components from hawthorn. Due to the remedial action of hyperoside and other flavonoids from hawthorn, their determination is important for the standardization of extract and preparation quality. The extraction of the flavonoids from a mixture of hawthorn (C. oxycantha and C. monogyna) flowe

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Bekbolatova, Elmira, Wirginia Kukula-Koch, Tomasz Baj, et al. "Phenolic composition and antioxidant potential of different organs of Kazakh Crataegus almaatensis Pojark: A comparison with the European Crataegus oxyacantha L. flowers." Open Chemistry 16, no. 1 (2018): 415–26. http://dx.doi.org/10.1515/chem-2018-0048.

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AbstractThe aim of this study was to investigate polyphenolic composition of different parts (leaves, flowers and fruits) of Crataegus almaatensis Pojark, an endemic plant of Kazakhstan, and compare it to a well known European Crataegus oxyacantha L. flowers. A Qual-Quant analysis was performed based on HR-MS measurements on 22 secondary metabolites: flavonoids and phenolic acids. Another goal was to evaluate the antioxidant potency of hawthorn extracts which was expressed in the total phenolic content and DPPH scavenging potency tests. Leaf extracts from C. almaatensis were found to be the mo

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Noor Zahra, Syeda Mah-e., Saadia Shahzad Alam, Maryam Nadeem, Huma Zia Arain, Neelofer Warraich, and Maryam Piracha. "Comparative Evaluation of Prophylactic and THP of CO (Hawthorn) Fruit with Atorvastatin in Murine Model of Dyslipidemia." Pakistan Journal of Medical and Health Sciences 15, no. 11 (2021): 2913–16. http://dx.doi.org/10.53350/pjmhs2115112913.

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Background: Dyslipidemia or hyperlipidemia is a consequential condition resulting from derangement in lipid profile. Standard treatment such as Atorvastatin though beneficial, causes many serious adverse effects thus an alternative like Crataegus oxyacantha (Hawthorn) with hypolipidemic potential was investigated. Aims: To evaluate prophylactic and therapeutic hypolipidemic potential of crataegus oxyacantha (hawthorn) fruit in comparison with atorvastatin in murine model of dyslipidemia through assessing physiological parameter i.e., weight and serum biochemical parameters i.e., lipid profile:

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Zahra, Syeda Mah-E.-Noor, Saadia Shahzad Alam, Maryam Nadeem, Huma Zia Arain, Neelofer Warraich, and Maryam Piracha. "Comparative Evaluation of Prophylactic and Therapeutic Hypolipidemic Potential of Crataegus Oxyacantha Fruit with Atorvastatin in Murine Model of Dyslipidemia." Pakistan Journal of Medical and Health Sciences 16, no. 1 (2022): 25–28. http://dx.doi.org/10.53350/pjmhs2216125.

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Background: Dyslipidemia or hyperlipidemia is a consequential condition resulting from derangement in lipid profile. Standard treatment such as Atorvastatin though beneficial, causes many serious adverse effects thus an alternative like Crataegus oxyacantha (Hawthorn) with hypolipidemic potential was investigated. Aims: To evaluate prophylactic and therapeutic hypolipidemic potential of crataegus oxyacantha (hawthorn) fruit in comparison with atorvastatin in murine model of dyslipidemia through assessing physiological parameter i.e., weight and serum biochemical parameters i.e., lipid profile:

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González-Jiménez, Francisco Erik, Juan Alfredo Salazar-Montoya, Graciano Calva-Calva, and Emma Gloria Ramos-Ramírez. "Phytochemical Characterization, In Vitro Antioxidant Activity, and Quantitative Analysis by Micellar Electrokinetic Chromatography of Hawthorn (Crataegus pubescens) Fruit." Journal of Food Quality 2018 (July 25, 2018): 1–11. http://dx.doi.org/10.1155/2018/2154893.

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Due to their antioxidant properties, polyphenolic compounds are considered beneficial for human health. In this work, we investigated the polyphenol profile and antioxidant activity of edible tejocote (Crataegus pubescens) fruit extracts by micellar electrokinetic chromatography (MEKC) and HPLC/UV. The major phenolic compounds in the pulp extracts were (+)-catechin (9.17 ± 0.20 mg/100 mg dry fruit), (−)-epicatechin (4.32 ± 0.11 mg/100 mg dry fruit), and chlorogenic acid (5.60 ± 0.24 mg/100 mg dry fruit). The total phenolic content was 168.6 ± 0.9 mg gallic acid equivalent/g dry fruit; the tota

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Martinelli, Federico, Anna Perrone, Sanaz Yousefi, et al. "Botanical, Phytochemical, Anti-Microbial and Pharmaceutical Characteristics of Hawthorn (Crataegus monogyna Jacq.), Rosaceae." Molecules 26, no. 23 (2021): 7266. http://dx.doi.org/10.3390/molecules26237266.

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Hawthorn (Crataegus monogyna Jacq.) is a wild edible fruit tree of the genus Crataegus, one of the most interesting genera of the Rosaceae family. This review is the first to consider, all together, the pharmaceutical, phytochemical, functional and therapeutic properties of C. monogyna based on numerous valuable secondary metabolites, including flavonoids, vitamin C, glycoside, anthocyanin, saponin, tannin and antioxidants. Previous reviews dealt with the properties of all species of the entire genera. We highlight the multi-therapeutic role that C. monogyna extracts could have in the treatmen

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Hadjimitova, Vera. "Relationship between antioxidant properties and GC-MS component composition of extracts from flowers, leaves and fruits of Crataegus Oxycanta." JOURNAL OF ADVANCES IN AGRICULTURE 4, no. 1 (2015): 310–15. http://dx.doi.org/10.24297/jaa.v4i1.4299.

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The aim of this study was to perform a comparative investigation of the antioxidant effect of Crataegus oxycanthas’ flowers, leaves, green and ripe fruits probes and to relate the obtained results with the ones of the accomplished qualitative GC-MS analysis of the antioxidant components participating in the studied standardized ethanol extracts. We established that the three extracts have well manifested antioxidant properties in three biological relevant model systems with different mechanism of generation of ROS: Fe-induced lipid peroxidation, UV induced deoxyribose damage and horse-radish p

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Tahirović, Azra, and Neđad Bašić. "PHENOLIC CONTENT AND ANTIOXIDANT ACTIVITY OF CRATAEGUS MONOGYNA L. FRUIT EXTRACTS." Radovi Šumarskog fakulteta Univerziteta u Sarajevu 44, no. 2 (2014): 29–40. http://dx.doi.org/10.54652/rsf.2014.v44.i2.99.

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UDK: 547.56:582.711.714 582.711.714:581.47 The aim of this work was to determine the content of total polyphenols, total flavonoids, total monomeric anthocyanins, total proanthocyanidins, and antioxidant activity of Crataegus monogyna L. fruit in water, hydroalcohol and alcohol extracts. Phenolic content and antioxidant assay of the different fruit extracts was determined using spectrophotometric methods. Obtained results indicated that the content of total polyphenols in the investigated extracts varied from 2.01 to 4.60 mg GAE g-1 of fresh hawthorn fruit. The content of flavonoid

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Balbueno, Melina Castilho de Souza, Kleber da Cunha Peixoto, and Cidéli de Paula Coelho. "Evaluation of the Efficacy of Crataegus oxyacantha in Dogs with Early-Stage Heart Failure." Homeopathy 109, no. 04 (2020): 224–29. http://dx.doi.org/10.1055/s-0040-1710021.

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Abstract Background Myxomatous mitral valve disease (MMVD) is the most common cardiopathy in middle-aged dogs. When the dog is asymptomatic and has an enlarged left atrium, treatment is beneficial; however, some allopathic drugs are very costly and may produce side effects. To extend the duration of this asymptomatic phase, complementary therapies such as herbal medicine and homeopathy are available. Although herbal therapy with extract of Crataegus oxyacantha is beneficial, there is a risk of adverse reactions—unlike with homeopathy, where the risk is minimized with the administration of ultr

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ahmadinasab, meysam, saeid Valipour chahardah charic2, and mahbubeh setorki. "Crataegus monogyna extract on renal histopathological changes in diabetic rats." Pars of Jahrom University of Medical Sciences 17, no. 2 (2019): 23–31. http://dx.doi.org/10.52547/jmj.17.2.23.

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Gal, Sang-Wan, Young-Jae Choi, and Soo-Jeong Cho. "Anti-Obesity Effect of Crataegus Fructus Extract from Chinese Cultivation." Journal of Life Science 21, no. 11 (2011): 1586–91. http://dx.doi.org/10.5352/jls.2011.21.11.1586.

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Swaminathan, J. K., M. Khan, I. K. Mohan, et al. "Cardioprotective properties of Crataegus oxycantha extract against ischemia-reperfusion injury." Phytomedicine 17, no. 10 (2010): 744–52. http://dx.doi.org/10.1016/j.phymed.2010.01.009.

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Abdel Salam, Omar M. E., Amany A. Sleem, and Nermeen Shafee. "Effect of Crataegus extract on carbon tetrachloride-induced hepatic damage." Comparative Clinical Pathology 21, no. 6 (2011): 1719–26. http://dx.doi.org/10.1007/s00580-011-1356-7.

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Kandilarov, Ilin, Petya Gardjeva, Maria Georgieva-Kotetarova та ін. "Effect of Plant Extracts Combinations on TNF-α, IL-6 and IL-10 Levels in Serum of Rats Exposed to Acute and Chronic Stress". Plants 12, № 17 (2023): 3049. http://dx.doi.org/10.3390/plants12173049.

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Oxydative stress, anxiety and depression are associated with changes in cytokine levels. Natural products, including individual and combined plant extracts, have the potential to be used in the treatment of neuropsychiatric disorders. The goal of this study is to investigate the effects of two combined plant extracts, rich in flavonoids, on the levels of the cytokines TNF-α, IL-6, and IL-10 in rats subjected to models of acute cold stress and chronic unpredictable stress. The study utilized common medicinal plants such as Valeriana officinalis, Melissa officinalis, Crataegus monogyna, Hypericu

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Mecheri, Amira, Wassila Benabderrahmane, Amel Amrani, et al. "Hepatoprotective Effects of Algerian Crataegus oxyacantha Leaves." Recent Patents on Food, Nutrition & Agriculture 10, no. 1 (2019): 70–75. http://dx.doi.org/10.2174/2212798410666180730095456.

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Background: Hawthorn (C. oxyacantha), a common edible plant, is widely used for the preparation of a different foodstuff and is also used in traditional medicine to treat heart problems and gastrointestinal ailments. Recently, a few patents of Crataegus preparation for protective effects (prevention of cardiovascular and hepatic diseases) have been developed. </P><P> Objective: The current study aimed to explore the antioxidant and hepatoprotective effects of nbutanol extract of Crataegus oxyacantha leaves in acute liver damage induced by Doxorubicin (DOX). </P><P> Meth

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Lis, Magdalena, Marianna Szczypka, Agnieszka Suszko-Pawłowska, Anna Sokół-Łętowska, Alicja Kucharska, and Bożena Obmińska-Mrukowicz. "Hawthorn (Crataegus monogyna) Phenolic Extract Modulates Lymphocyte Subsets and Humoral Immune Response in Mice." Planta Medica 86, no. 02 (2019): 160–68. http://dx.doi.org/10.1055/a-1045-5437.

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AbstractThis study investigated the effect of hawthorn (Crataegus monogyna) phenolic extract on lymphocyte subsets in the lymphoid organs in nonimmunized mice and on humoral immune response in sheep red blood cell-immunized mice. Hawthorn phenolic extract (50, 100, 200 mg/kg) was administered orally five or ten times. Sheep red blood cells were injected 24 h after administration of the last extract dose. The lymphocyte subsets were assessed 24 and 72 h after the last dose. Humoral immune response was determined 4 and 7 days after immunization. Five doses of the extract decreased the percentage

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Bahri-Sahloul, Radhia, Radhia Ben Fredj, Naima Boughalleb, et al. "Phenolic Composition and Antioxidant and Antimicrobial Activities of Extracts Obtained from Crataegus azarolus L. var. aronia (Willd.) Batt. Ovaries Calli." Journal of Botany 2014 (January 20, 2014): 1–11. http://dx.doi.org/10.1155/2014/623651.

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Objective. Plant cell culture is an innovative technology to produce a variety of substances. Numerous plants synthesize among their secondary metabolites phenolic compounds which possess antioxidant and antimicrobial effects. Hawthorn (Crataegus) is one of these plants which has long been used in folk medicine and is widely utilized in pharmaceutical preparations mainly in neuro- and cardiosedative actions. Methods and Results. The production of polyphenol by fifty-two-week-old Crataegus azarolus var. aronia calli was studied in relation to growth variation and antioxidant and antimicrobial c

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Wang, Xinwen, Yan Liang, Jian Shi, Hao-jie Zhu, and Barry Bleske. "Crataegus Special Extract WS 1442 Effects on eNOS and microRNA 155." Planta Medica 84, no. 15 (2018): 1094–100. http://dx.doi.org/10.1055/a-0601-7083.

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AbstractIncreased expression of microRNA 155 (miR-155) results in a decrease in endothelial nitric oxide synthase (eNOS) expression and impaired endothelial function. Factors that have been shown to increase expression of miR-155 may be mitigated by WS 1442, an extract of hawthorn leaves and flowers (Crataegus special extract) that contains a range of pharmacologically active substances including oligomeric proanthocyanidins and flavonoids. The purpose of this study is to determine the effect of WS 1442 on the expression of miR-155 and eNOS in the presence of tumor necrosis factor (TNF-α). Hum

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Müller, Andreas, Werner Linke, and Wolfgang Klaus. "Crataegus Extract Blocks Potassium Currents in Guinea Pig Ventricular Cardiac Myocytes." Planta Medica 65, no. 4 (1999): 335–39. http://dx.doi.org/10.1055/s-1999-13997.

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Kim, Soon Hoe, Keon Wook Kang, Kye Won Kim, and Nak Doo Kim. "Procyanidins in crataegus extract evoke endothelium-dependent vasorelaxation in rat aorta." Life Sciences 67, no. 2 (2000): 121–31. http://dx.doi.org/10.1016/s0024-3205(00)00608-1.

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Maistro, E., B. Yonekubo, and E. Marques. "Genotoxic assessment of Crataegus oxyacantha fruits extract in cells of mice." Toxicology Letters 238, no. 2 (2015): S95. http://dx.doi.org/10.1016/j.toxlet.2015.08.316.

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Idris-Khodja, N., C. Auger, E. Koch, and V. B. Schini-Kerth. "Crataegus special extract WS®1442 prevents aging-related endothelial dysfunction." Phytomedicine 19, no. 8-9 (2012): 699–706. http://dx.doi.org/10.1016/j.phymed.2012.04.005.

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Müller, A., W. Linke, Y. Zhao, and W. Klaus. "Crataegus extract prolongs action potential duration in guinea-pig papillary muscle." Phytomedicine 3, no. 3 (1996): 257–61. http://dx.doi.org/10.1016/s0944-7113(96)80063-8.

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