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Journal articles on the topic 'CRD5'

Author: Grafiati

Published: 28 June 2021

Last updated: 29 July 2025

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1

Yadav, Poonam, S. R. Singh, and Mala Trivedi. "Characterization of fungi isolated from cattle dung with potential lignocellulolytic activities." Ecology, Environment and Conservation 29 (2023): 144–51. http://dx.doi.org/10.53550/eec.2023.v29i02s.027.

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Agricultural wastes not only serve as sources of environmental pollutions, but also serve as magnificent source of plant nutrients and natural repositories of bio-tools especially fungi of industrial interest for lignocellulolytic enzymes production. However, residues management particularly in rice–wheat system is a tedious phenomenon due to narrow gap between harvesting and sowing of these two crops. Hence, microbial intervention is one of the key options that may use successfully for their management. Thus, cellulolytic fungi were isolated from the cattle dung collected from various locatio

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Zahari, R., N. Halimoon, M. F. Ahmad, and S. K. Ling. "Antifungal Compound Isolated fromCatharanthus roseusL. (Pink) for Biological Control of Root Rot Rubber Diseases." International Journal of Analytical Chemistry 2018 (2018): 1–6. http://dx.doi.org/10.1155/2018/8150610.

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Rigidoporus microporus, Ganoderma philippii,andPhellinus noxiusare root rot rubber diseases and these fungi should be kept under control with environmentally safe compounds from the plant sources. Thus, an antifungal compound isolated fromCatharanthus roseuswas screened for its effectiveness in controlling the growth of these fungi. The antifungal compound isolated fromC. roseusextract was determined through thin layer chromatography (TLC) and nuclear magnetic resonance (NMR) analysis. EachC. roseusof the DCM extracts was marked as CRD1, CRD2, CRD3, CRD4, CRD5, CRD6, and CRD7, respectively. TL

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Waidner, Barbara, Klaus Melchers, Frank Nils Stähler, Manfred Kist, and Stefan Bereswill. "The Helicobacter pylori CrdRS Two-Component Regulation System (HP1364/HP1365) Is Required for Copper-Mediated Induction of the Copper Resistance Determinant CrdA." Journal of Bacteriology 187, no. 13 (2005): 4683–88. http://dx.doi.org/10.1128/jb.187.13.4683-4688.2005.

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ABSTRACT Here we describe that the Helicobacter pylori sensor kinase produced by HP1364 and the response regulator produced by HP1365 and designated CrdS and CrdR, respectively, are both required for transcriptional induction of the H. pylori copper resistance determinant CrdA by copper ions. CrdRS-deficient mutants lacked copper induction of crdA expression and were copper sensitive. A direct role of CrdR in transcriptional regulation of crdA was confirmed by in vitro binding of CrdR to the crdA upstream region. A 21-nucleotide sequence located near the crdA promoter was shown to be required

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Connolly, Sarah A., Daniel J. Landsburg, Andrea Carfi, Don C. Wiley, Roselyn J. Eisenberg, and Gary H. Cohen. "Structure-Based Analysis of the Herpes Simplex Virus Glycoprotein D Binding Site Present on Herpesvirus Entry Mediator HveA (HVEM)." Journal of Virology 76, no. 21 (2002): 10894–904. http://dx.doi.org/10.1128/jvi.76.21.10894-10904.2002.

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ABSTRACT Binding of herpes simplex virus (HSV) envelope glycoprotein D (gD) to a cell surface receptor is an essential step of virus entry. We recently determined the crystal structure of gD bound to one receptor, HveA. HveA is a member of the tumor necrosis factor receptor family and contains four characteristic cysteine-rich domains (CRDs). The first two CRDs of HveA are necessary and sufficient for gD binding. The structure of the gD-HveA complex reveals that 17 amino acids in HveA CRD1 and 4 amino acids in HveA CRD2 directly contact gD. To determine the contribution of these 21 HveA residu

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Riggle, Perry J., and Carol A. Kumamoto. "Role of a Candida albicans P1-Type ATPase in Resistance to Copper and Silver Ion Toxicity." Journal of Bacteriology 182, no. 17 (2000): 4899–905. http://dx.doi.org/10.1128/jb.182.17.4899-4905.2000.

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ABSTRACT Copper ion homeostasis is complicated in that copper is an essential element needed for a variety of cellular processes but is toxic at excess levels. To identify Candida albicans genes that are involved in resistance to copper ion toxicity, a library containing inserts of C. albicans genomic DNA was used to complement the copper sensitivity phenotype of a Saccharomyces cerevisiae cup1Δ strain that is unable to produce Cup1p, a metallothionein (MT) responsible for high-level copper ion resistance. A P1-type ATPase (CPx type) that is closely related to the human Menkes and Wilson disea

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Zhang, Kaige, Danqing Yin, Bin Wang, et al. "Ultrasonic Cavitation Erosion Behavior of CoCrxFeMnNi High-Entropy Alloy Coatings Prepared by Plasma Cladding." Metals 13, no. 3 (2023): 515. http://dx.doi.org/10.3390/met13030515.

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CoCrxFeMnNi (x represents the atomic percentage of Cr element, x = 20, 25, 30, and 35, denoted as Cr20, Cr25, Cr30, and Cr35 alloys) high-entropy alloy (HEA) coatings were cladded by plasma arc on the surface of 0Cr13Ni5Mo steel. The effects of Cr elements on the cavitation erosion mechanisms were studied by comparing the differences of microstructure, microhardness, cavitation erosion volume loss (CVL), cavitation erosion volume loss rate (CER), and eroded surface morphologies between the coatings. As the Cr content increased, the microhardness of the coatings increased continuously, and the

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Reitmayer, Hans-Eric, and Dan Monea. "Relationship between lower limb power and dynamic stability in volleball players." Timisoara Physical Education and Rehabilitation Journal 14, no. 26 (2021): 29–33. http://dx.doi.org/10.2478/tperj-2021-0003.

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Abstract Introduction As in all team sports, lower limb power is an important quality of any player. Especially when it comes to volleyball, a game that relies on jumping performance on almost every action except reception. Another crucially important quality of the lower limbs is dynamic stability. Without the latter, the frequency of injuries rises, and that is something any coach or player wants to avoid. The question arises: Are the two qualities related? Aim The study aimed to investigate the correlation between lower limb power and force measured using an inertial flywheel training/measu

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Willett, Brian J., Elizabeth L. McMonagle, Francesca Bonci, Mauro Pistello, and Margaret J. Hosie. "Mapping the Domains of CD134 as a Functional Receptor for Feline Immunodeficiency Virus." Journal of Virology 80, no. 15 (2006): 7744–47. http://dx.doi.org/10.1128/jvi.00722-06.

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ABSTRACT The feline homologue of CD134 is the primary binding receptor for feline immunodeficiency virus (FIV), targeting the virus preferentially to activated CD4+ helper T cells. However, strains of FIV differ in utilization of CD134; the prototypic strain PPR requires a minimal determinant in the first cysteine-rich domain (CRD1) of feline CD134 to confer near-optimal receptor function, while strains such as GL8 require additional determinants in the CD134 CRD2. We map this determinant to a loop in CRD2 governing the interaction between the receptor and its ligand; the amino acid substituti

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Jian, Jinlong, Shuai Zhao, Qingyun Tian, et al. "Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domains." FEBS Letters 587, no. 21 (2013): 3428–36. http://dx.doi.org/10.1016/j.febslet.2013.09.024.

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Trabsa, Hayat, Abderrahman Baghiani, Naouel Boussoualim, Imane Krache, and Lekhmici Arrar. "The In vivo and in vitro antioxidant and anti-hemolytic effect of Algerian Centaurea calcitrapa L. extracts." Journal of Drug Delivery and Therapeutics 10, no. 5 (2020): 202–7. http://dx.doi.org/10.22270/jddt.v10i5.4402.

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In the present study, aerial part of Centaurea calcitrapa L. were extracted with solvent of varying polarity allowed their separation into three main subfractions, the analysis of methanol crud (CrE), chloroform (ChE) and ethyl acetate (EaE) extracts, showed that the EaE contains the highest amount of flavonoids (50,71 ± 0,65 mg Eq / Quercetin g dry extract and 31,96 ± 0,39 mg Eq Rutin / g dry extract). Using DPPH assay, the highest activity was observed with EaE (IC50 = 0,037 ± 0,0006 mg / ml). The β-carotene / linoleic acid bleaching assay revealed that the extracts have a very important ant

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Sobolewska, Małgorzata, Marta Świerczyńska, Mariola Dorecka, Dorota Wyględowska-Promieńska, Maciej R. Krawczyński, and Ewa Mrukwa-Kominek. "CDHR1-Related Cone–Rod Dystrophy: Clinical Characteristics, Imaging Findings, and Genetic Test Results—A Case Report." Medicina 59, no. 2 (2023): 399. http://dx.doi.org/10.3390/medicina59020399.

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Background: Cone–rod dystrophies (CRDs) are a heterogeneous group of inherited retinal diseases (IRDs) characterized by cone photoreceptor loss, that is followed by subsequent rod photoreceptor impairment. Case presentation: A 49-year-old man complaining of diminution of vision in both eyes (OU) was referred to our outpatient clinic. He reported visual loss for 5 years, but it was most progressive during the last few months. The best-corrected visual acuity (BCVA) at presentation was 0.4 in the right eye (RE) and 1.0 in the left eye (LE). Fundus fluorescein angiography (FFA) revealed granular

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Wang, Linya, Zhen Han, Marisa Yang, et al. "Abstract 5793: Functional DKK1 antibodies binding to cysteine-rich domain 1 or 2 of hDKK1 demonstrate antagonistic activities on tumor suppression or TCF/LEF signaling." Cancer Research 84, no. 6_Supplement (2024): 5793. http://dx.doi.org/10.1158/1538-7445.am2024-5793.

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Abstract Wnt signaling plays an important role in embryonic development and tumorigenesis. These biological effects are exerted by activation of the β-catenin/TCF transcription complex and consequent regulation of a set of downstream genes. DKK1 has been shown to be a potent inhibitor of Wnt signaling via competing Wnt binding to LRP5/6. DKK1 is tumorigenic in multiple cancer types and also immunosuppressive via MDSCs and NK cells. Emerging evidence indicates that DKK1 has been involved in T cell differentiation and induction of cancer evasion of immune surveillance by accumulating MDSCs. Cons

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13

Yadav, Poonam, Shiv Ram Singh, Mala Trivedi, and Sujeet Pratap Singh. "Termite gut microbiome being a rich source of potential lignocellulolytic bacterial strains." Research Journal of Biotechnology 19, no. 9 (2024): 36–40. http://dx.doi.org/10.25303/1909rjbt036040.

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A study was carried out to identify prospective cellulose degrading bacteria isolated from termite gut collected from various agriculture sites. Eight of the bacterial isolates displayed a very distinct zone of clearing on CMC (Carboxylmethyl cellulose) agar media after staining with 1% Congo red, indicating that they may have cellulose degrading ability. On a CMC agar plate, CRDB6 had the largest colony diameter (3.08 cm) as well as clear zone diameter (0.96 cm), however CRDB 1 has maximum cellulolytic activity (1.45 cm) followed by CRDB5 and CRDB6 (1.33 cm and 1.28 cm) respectively. CRDB3, C

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Hatamihanza, Hamide, Seyed Ebrahim Alavi, Hasan Ebrahimi Shahmabadi, and Azim Akbarzadeh. "Preparation, Characterization and Immunostimulatory Effects of CRD2 and CRD3 from TNF Receptor-1 Encapsulated into Pegylated Liposomal Nanoparticles." International Journal of Peptide Research and Therapeutics 26, no. 2 (2019): 745–53. http://dx.doi.org/10.1007/s10989-019-09882-8.

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Devarajan, Shine, та Jeya Sundara Sharmila. "Computational Studies of Beta Amyloid (Aβ42) with p75NTR Receptor: A Novel Therapeutic Target in Alzheimer’s Disease". Advances in Bioinformatics 2014 (11 листопада 2014): 1–6. http://dx.doi.org/10.1155/2014/736378.

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Alzheimer’s disease is a neurodegenerative disorder characterized by the accumulation of beta amyloid plaques (Aβ) which can induce neurite degeneration and progressive dementia. It has been identified that neuronal apoptosis is induced by binding of Aβ42 to pan neurotrophin receptor (p75NTR) and gave the possibility that beta amyloid oligomer is a ligand for p75NTR. However, the atomic contact point responsible for molecular interactions and conformational changes of the protein upon binding was not studied in detail. In view of this, we conducted a molecular docking and simulation study to i

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16

Parsons, Andrew. "CRDF Global." Impact 2017, no. 4 (2017): 64–65. http://dx.doi.org/10.21820/23987073.2017.4.64.

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Mungas, Greg S., and Christopher B. Dreyer. "Cavity Ringdown Spectroscopy in a Hollow Bragg Waveguide: Electromagnetic Theory and Modeling." Applied Spectroscopy 63, no. 11 (2009): 1262–75. http://dx.doi.org/10.1366/000370209789806957.

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Cavity ringdown spectroscopy (CRDS) is a gas sensing technique in which an optical cavity is formed by two or more highly reflective mirrors. Herein we present an overview and historical perspective of CRDS implementations that seek to reduce or eliminate some of the disadvantages of conventional CRDS by modifications to the ringdown cavity (RDC). The hollow waveguide (HWG) CRDS concept that we introduce in this paper reduces some of the disadvantages of conventional CRDS by utilizing a hollow waveguide as the RDC. We develop the basic mathematical theory and model for the HWG-CRDS concept and

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18

Białowiec, Andrzej, Monika Micuda, Antoni Szumny, Jacek Łyczko, and Jacek Koziel. "The Proof-of-the-Concept of Application of Pelletization for Mitigation of Volatile Organic Compounds Emissions from Carbonized Refuse-Derived Fuel." Materials 12, no. 10 (2019): 1692. http://dx.doi.org/10.3390/ma12101692.

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Waste can be effectively reused through the production of carbonized refuse-derived fuel (CRDF) that enables further energy recovery. Developing cleaner production of CRDF requires consideration of practical issues of storage and handling. Thus, it needs to be ensured that CRDF does not pose an excessive risk to humans and the ecosystem. Very few studies indicate a wide variety of volatile organic compounds (VOCs) are present in CRDF, some of which are toxic. During handling, storage, transportation, and use of VOC-rich CRDF, workers and end-users could be exposed to emissions that could pose

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Kim, Soo-Kyung, Yalu Chen, Ravinder Abrol, William A. Goddard, and Brian Guthrie. "Activation mechanism of the G protein-coupled sweet receptor heterodimer with sweeteners and allosteric agonists." Proceedings of the National Academy of Sciences 114, no. 10 (2017): 2568–73. http://dx.doi.org/10.1073/pnas.1700001114.

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The sweet taste in humans is mediated by the TAS1R2/TAS1R3 G protein-coupled receptor (GPCR), which belongs to the class C family that also includes the metabotropic glutamate and γ-aminobutyric acid receptors. We report here the predicted 3D structure of the full-length TAS1R2/TAS1R3 heterodimer, including the Venus Flytrap Domains (VFDs) [in the closed–open (co) active conformation], the cysteine-rich domains (CRDs), and the transmembrane domains (TMDs) at the TM56/TM56 interface. We observe that binding of agonists to VFD2 of TAS1R2 leads to major conformational changes to form a TM6/TM6 in

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Resta-Lenert, Silvia, Srustidhar Das, Surinder K. Batra, and Samuel B. Ho. "Muc17 protects intestinal epithelial cells from enteroinvasive E. coli infection by promoting epithelial barrier integrity." American Journal of Physiology-Gastrointestinal and Liver Physiology 300, no. 6 (2011): G1144—G1155. http://dx.doi.org/10.1152/ajpgi.00138.2010.

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The membrane-bound mucin MUC17 (mouse homolog Muc3) is highly expressed on the apical surface of intestinal epithelia and is thought to play a role in epithelial restitution and protection. Therefore, we hypothesized that MUC17 has a role in protection of the intestinal mucosa against luminal pathogens. Human intestinal cell lines were transfected by electroporation (Caco-2 and HT 29/19A) and by retroviral expression vector (LS174T, a cell line with high levels of MUC17 expression) using MUC17 siRNA. Transepithelial electrical resistance, permeability, tight-junction protein expression, adhesi

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Harris, N., M. Super, M. Rits, G. Chang, and RA Ezekowitz. "Characterization of the murine macrophage mannose receptor: demonstration that the downregulation of receptor expression mediated by interferon-gamma occurs at the level of transcription." Blood 80, no. 9 (1992): 2363–73. http://dx.doi.org/10.1182/blood.v80.9.2363.2363.

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Abstract The macrophage mannose receptor (MMR) is a 175-Kd cell-surface transmembrane glycoprotein that is expressed on tissue macrophages where it functions both to mediate the uptake of mannose-rich glycoproteins and as a phagocytic receptor for bacteria, yeasts, and other pathogenic microorganisms. In this report we describe the cloning of the full-length cDNA of the mouse macrophage mannose receptor and we investigate the level at which interferon gamma (IFN-gamma) downregulates mannose receptor expression. The latter is a marker of the functional state of the cell as high levels are expre

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Harris, N., M. Super, M. Rits, G. Chang, and RA Ezekowitz. "Characterization of the murine macrophage mannose receptor: demonstration that the downregulation of receptor expression mediated by interferon-gamma occurs at the level of transcription." Blood 80, no. 9 (1992): 2363–73. http://dx.doi.org/10.1182/blood.v80.9.2363.bloodjournal8092363.

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The macrophage mannose receptor (MMR) is a 175-Kd cell-surface transmembrane glycoprotein that is expressed on tissue macrophages where it functions both to mediate the uptake of mannose-rich glycoproteins and as a phagocytic receptor for bacteria, yeasts, and other pathogenic microorganisms. In this report we describe the cloning of the full-length cDNA of the mouse macrophage mannose receptor and we investigate the level at which interferon gamma (IFN-gamma) downregulates mannose receptor expression. The latter is a marker of the functional state of the cell as high levels are expressed on r

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23

Abe, H. "Trace-moisture measurement using cavity ring-down spectroscopy at NMIJ." Journal of Physics: Conference Series 2439, no. 1 (2023): 012001. http://dx.doi.org/10.1088/1742-6596/2439/1/012001.

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Abstract Trace-moisture standards traceable to the International System of Units (SI) used for the performance test of trace-moisture analyzers and trace-moisture measurement systems based on cavity ring-down spectroscopy (CRDS) developed at the National Metrology Institute of Japan (NMIJ) are briefly reviewed. The magnetic-suspension-balance/diffusion-tube humidity generator, which was the first generator used for the trace-moisture standard developed at NMIJ, is presented. Three measurement systems based on CRDS, which are wavelength-meter-controlled CRDS, dual-laser CRDS, and miniaturized C

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Long, Jin Ming, Quan Bin Liu, Kun Yu Zhao, Qi Long Yong, and Jie Su. "Effect of Cl^- Content, pH Value and CO₂ on Electrochemical Corrosion Features of Cr15 Super Martensitic Stainless Steel." Advanced Materials Research 738 (August 2013): 92–96. http://dx.doi.org/10.4028/www.scientific.net/amr.738.92.

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The corrosion behavior of a Cr15 super martensitic stainless steel (Cr15 SMSS) was investigated in NaCl solutions by means of potentiodynamic polarization and electrochemical impedance spectroscopy (EIS). Effects of Cl-content, pH value and saturated CO2on corrosion were sdudied. It was found that the parameters of maintaining passivity current density (ip), the critical pitting potential (Eb) and charge transfer resistance (Rt) of Cr15 SMSS varied widely under different conditions. The corrosion resistance of Cr15 SMSS decrease with increasing Cl-concentration and lowering pH value. Bothipand

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Białowiec, Andrzej, Monika Micuda, Antoni Szumny, Jacek Łyczko, and Jacek Koziel. "Waste to Carbon: Influence of Structural Modification on VOC Emission Kinetics from Stored Carbonized Refuse-Derived Fuel." Sustainability 11, no. 3 (2019): 935. http://dx.doi.org/10.3390/su11030935.

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The torrefaction of municipal solid waste is one of the solutions related to the Waste to Carbon concept, where high-quality fuel—carbonized refuse-derived fuel (CRDF)—is produced. An identified potential problem is the emission of volatile organic compounds (VOCs) during CRDF storage. Kinetic emission parameters have not yet been determined. It was also shown that CRDF can be pelletized for energy densification and reduced volume during storage and transportation. Thus, our working hypothesis was that structural modification (via pelletization) might mitigate VOC emissions and influence emiss

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Luyten, Tom, Susy Braun, Susan van Hooren, and Luc de Witte. "How groups of nursing home residents respond to “the CRDL”: a pilot study." Journal of Enabling Technologies 12, no. 4 (2018): 145–54. http://dx.doi.org/10.1108/jet-05-2018-0025.

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Purpose The purpose of this paper is to describe whether and how groups of nursing home residents respond to the interactive device “the CRDL”. The CRDL can translate touches between people into sounds. It recognises the type of touch and adjusts the produced sound accordingly. Design/methodology/approach This was as an observational explorative study. Responses were coded and analysed using an existing theoretical framework. Findings The CRDL creates an atmosphere of playfulness and curiosity. It lowers the threshold to touch, provides an incentive to touch and encourages experimentation with

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27

Waidner, Barbara, Klaus Melchers, Igor Ivanov, et al. "Identification by RNA Profiling and Mutational Analysis of the Novel Copper Resistance Determinants CrdA (HP1326), CrdB (HP1327), and CzcB (HP1328) in Helicobacter pylori." Journal of Bacteriology 184, no. 23 (2002): 6700–6708. http://dx.doi.org/10.1128/jb.184.23.6700-6708.2002.

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ABSTRACT Mechanisms involved in maintaining cytoplasmic metal ion homeostasis play a central role in the adaptation of Helicobacter pylori to the changing gastric environment. An investigation of the global regulatory responses to copper ions by using RNA profiling with a threshold factor of 4.0 revealed that copper induces transcription of 19 H. pylori genes and that only the ferritin gene pfr is repressed. The 57-fold copper induction identified the HP1326 gene encoding an H. pylori-specific protein as a candidate for a novel copper resistance determinant. The HP1326 gene is expressed as a m

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Białowiec, Andrzej, Monika Micuda, and Jacek Koziel. "Waste to Carbon: Densification of Torrefied Refuse-Derived Fuel." Energies 11, no. 11 (2018): 3233. http://dx.doi.org/10.3390/en11113233.

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In this work, for the first time, the feasibility of obtaining carbonized refuse-derived fuel (CRDF) pelletization from municipal solid waste (MSW) was shown. Production of CRDF by torrefaction of MSW could be the future of recycling technology. The objective was to determine the applied pressure needed to produce CRDF pellets with compressive strength (CS) comparable to conventional biomass pellets. Also, the hypothesis that a binder (water glass (WG)) applied to CRDF as a coating can improve CS was tested. The pelletizing was based on the lab-scale production of CRDF pellets with pressure ra

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Klenk, Juergen, Dina Mikdadi, Bhavani Singh, et al. "Abstract 1084: Analyzing artificial intelligence (AI) policy for cancer research data programs." Cancer Research 85, no. 8_Supplement_1 (2025): 1084. https://doi.org/10.1158/1538-7445.am2025-1084.

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Abstract Purpose: The National Cancer Institute’s (NCI) Cancer Research Data Commons (CRDC) supports the cancer research community by providing cloud-based, secure storage and analytic tools for multiple cancer data types (e.g., genomic, proteomic, imaging, and clinical trial data). CRDC is beginning to integrate artificial intelligence (AI) solutions, such as using AI to annotate medical images and making AI models and resources available for cancer researchers. As AI policies emerge, CRDC must track relevant guidelines to determine how AI can safely and compliantly unlock value for researche

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Saad Muofaq Al-Tamimi, Abtisam Jawad Ali, and Rawah A. Faraj. "The Impact of Two Types of Mycoplasma gallisepticum Vaccines on Broiler Chicken Respiratory System." University of Thi-Qar Journal of agricultural research 12, no. 2 (2023): 131–42. http://dx.doi.org/10.54174/utjagr.v12i2.273.

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This study aimed to evaluate the effect of vaccinating 1-day-old broilerchicks with two commercial vaccines such as live chronic respiratorydisease F strain (CRDF) and killed Mycoplasma gallisepticum (MG)vaccines on the respiratory system. For this purpose, one-day-old broilerchicks (n=120) were randomly divided into four groups; (n=30 birdseach). All groups were treated as followed: G1(CRDF): chicks werevaccinated with live CRDF vaccine (eye drop one drop 0.03ml/dose/10 5 ),G2 (killed MG): chicks were vaccinated with killed MG vaccine injectionwith 0.3ml s.c /3 x10 10 C.F.U/ml), G3: chicks we

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Guo, Dan, Ke Huang, Xiaolong Guan, et al. "Association between chronic respiratory diseases and frailty in Chinese elderly: a population-based longitudinal study." BMJ Open Respiratory Research 12, no. 1 (2025): e002171. https://doi.org/10.1136/bmjresp-2023-002171.

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BackgroundChronic respiratory diseases (CRDs) have been shown to be associated with frailty, but these findings have not yet reached a consensus. The aim of this study was to investigate the association between CRDs and frailty in the elderly using a nationally representative data from China.MethodsData from the China Health and Retirement Longitudinal Study (CHARLS) were analysed, including 3309 frailty-free participants followed for three waves from 2011. Frailty was assessed using the physical frailty phenotype scale, and CRDs were conformed by self-reported physician diagnoses. Cox proport

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Zhang, Jing, Xiaoyong Jiang, Han Gao, et al. "Structural Basis of a Novel Agonistic Anti-OX40 Antibody." Biomolecules 12, no. 9 (2022): 1209. http://dx.doi.org/10.3390/biom12091209.

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Agonistic antibodies targeting co-stimulating receptor OX40 on T cells are considered as important as (or complementary to) the immune checkpoint blockers in cancer treatment. However, none of these agonistic antibodies have reached the late stage of clinical development partially due to the lack of intrinsic potency with the correlation between binding epitope and activity of the antibody not well understood. Here, we identified a novel anti-OX40 agonistic antibody DF004, which stimulated the proliferation of human CD4+ T cells in vitro and inhibited tumor growth in a mouse model. Our crystal

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Bertsova, Y. V., M. V. Serebryakova, V. A. Anashkin, A. A. Baykov, and A. V. Bogachev. "A REDOX-REGULATED, HETERODIMERIC NADH:CINNAMATE REDUCTASE IN Vibrio ruber." Биохимия 89, no. 2 (2024): 261–78. http://dx.doi.org/10.31857/s0320972524020053ncwtx.

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Genes of putative reductases of α,β-unsaturated carboxylic acids are abundant among anaerobic and facultatively anaerobic microorganisms, yet substrate specificity has been experimentally verified for few encoded proteins. Here, we co-produced in Escherichia coli a heterodimeric protein of the facultatively anaerobic marine bacterium Vibrio ruber (GenBank SJN56019 and SJN56021; annotated as NADPH azoreductase and urocanate reductase, respectively) with Vibrio cholerae flavin transferase. The isolated protein (named Crd) consists of the sjn56021-encoded subunit CrdB (NADH:flavin, FAD binding 2,

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Weldemichael, Dawit A., and George T. Grossberg. "Circadian Rhythm Disturbances in Patients with Alzheimer's Disease: A Review." International Journal of Alzheimer's Disease 2010 (2010): 1–9. http://dx.doi.org/10.4061/2010/716453.

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Circadian Rhythm Disturbances (CRDs) affect as many as a quarter of Alzheimer's disease (AD) patients during some stage of their illness. Alterations in the suprachiasmatic nucleus and melatonin secretion are the major factors linked with the cause of CRDs. As a result, the normal physiology of sleep, the biological clock, and core body temperature are affected. This paper systematically discusses some of the causative factors, typical symptoms, and treatment options for CRDs in patients with AD. This paper also emphasizes the implementation of behavioral and environmental therapies before emb

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Johnson, Christopher M. "Use of the Continuous Response Digital Interface in the Evaluation of Live Musical Performance." Journal of Educational Technology Systems 20, no. 4 (1992): 261–71. http://dx.doi.org/10.2190/d6w9-n608-p8vt-419t.

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The present study was designed to assess the usefulness of the Continuous Response Digital Interface (CDRI) as a tool for assessing student performance in a field setting. Judges evaluated musical performance at a regional band festival using the conventional means of a musical score and orally taped comments, but also used a CRDI device to record ongoing assessment levels. CRDI dials were manipulated on a clockwise/counter-clockwise 250 degree continuum which recorded data, via a computer, three times per second. All three adjudicators indicated that the CRDI did not distract from any other a

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Fukuda, Yosuke, Tetsuya Homma, Shintaro Suzuki, et al. "High burden of Aspergillus fumigatus infection among chronic respiratory diseases." Chronic Respiratory Disease 15, no. 3 (2018): 279–85. http://dx.doi.org/10.1177/1479972318761654.

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Aspergillus fumigatus (AF) is a ubiquitous fungus in our environment and causes severe airway disorders. Chronic respiratory diseases (CRDs) are a series of chronic airway and lung diseases. Although both are chronic disorders, however, the relationships between AF and CRDs are still unclear. Therefore, we examined 104 Aspergillus species (spp.) isolated samples in our hospital during three consecutive years to further elucidate the relationships between Aspergillus spp. and CRDs. Based on sample isolates, we then grouped these into two groups, AF and non-AF, to retrospectively analyse the cli

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Klenk, Juergen, Dina Mikdadi, Chelsea Owens, et al. "Abstract 3568: Managing large-scale cancer research data programs." Cancer Research 84, no. 6_Supplement (2024): 3568. http://dx.doi.org/10.1158/1538-7445.am2024-3568.

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Abstract Purpose: The National Cancer Institute’s (NCI’s) Cancer Research Data Commons (CRDC) is a data ecosystem for the cancer research community that provides cloud-based, secure storage and analytic tools for many cancer data types, including genomic, proteomic, imaging, and clinical data. CRDC requires a carefully designed, federated data governance framework to enable CRDC’s goals to sustain a collaborative data environment where researchers can access timely, accurate, and relevant cancer data. Methods: In 2023, CRDC chartered a Data Governance Framework of Committees and Working Groups

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Gomez-Pelaez, Angel J., Ramon Ramos, Emilio Cuevas, Vanessa Gomez-Trueba, and Enrique Reyes. "Atmospheric CO<sub>2</sub>, CH<sub>4</sub>, and CO with the CRDS technique at the Izaña Global GAW station: instrumental tests, developments, and first measurement results." Atmospheric Measurement Techniques 12, no. 4 (2019): 2043–66. http://dx.doi.org/10.5194/amt-12-2043-2019.

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Abstract. At the end of 2015, a CO2/CH4/CO cavity ring-down spectrometer (CRDS) was installed at the Izaña Global Atmosphere Watch (GAW) station (Tenerife, Spain) to improve the Izaña Greenhouse Gases GAW Measurement Programme, and to guarantee the renewal of the instrumentation and the long-term maintenance of this program. We present the results of the CRDS acceptance tests, the raw data processing scheme applied, and the response functions used. Also, the calibration results, the implemented water vapor correction, the target gas injection statistics, the ambient measurements performed from

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Laohasiriwong, Wongsa, Nattapong Puttanapong, and Amornrat Luenam. "A comparison of spatial heterogeneity with local cluster detection methods for chronic respiratory diseases in Thailand." F1000Research 6 (October 9, 2017): 1819. http://dx.doi.org/10.12688/f1000research.12128.1.

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Background: The Centers for Disease Control and Prevention reported that deaths from chronic respiratory diseases (CRDs) in Thailand increased by almost 13% in 2010, along with an increased burden related to the disease. Evaluating the geographical heterogeneity of CRDs is important for surveillance. Previous studies have indicated that socioeconomic status has an effect on disease, and that this can be measured with variables such as night-time lights (NTLs) and industrial density (ID). However, there is no understanding of how NTLs and ID correlate with CRDs. We compared spatial heterogeneit

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Laohasiriwong, Wongsa, Nattapong Puttanapong, and Amornrat Luenam. "A comparison of spatial heterogeneity with local cluster detection methods for chronic respiratory diseases in Thailand." F1000Research 6 (March 6, 2018): 1819. http://dx.doi.org/10.12688/f1000research.12128.2.

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Background: The Centers for Disease Control and Prevention reported that deaths from chronic respiratory diseases (CRDs) in Thailand increased by almost 13% in 2010, along with an increased burden related to the disease. Evaluating the geographical heterogeneity of CRDs is important for surveillance. Previous studies have indicated that socioeconomic status has an effect on disease, and that this can be measured with variables such as night-time lights (NTLs) and industrial density (ID). However, there is no understanding of how NTLs and ID correlate with CRDs. We compared spatial heterogeneit

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Kyriacou, Helen M., Katie E. Steen, Ahmed Raza, et al. "In Vitro Inhibition of Plasmodium falciparum Rosette Formation by Curdlan Sulfate." Antimicrobial Agents and Chemotherapy 51, no. 4 (2007): 1321–26. http://dx.doi.org/10.1128/aac.01216-06.

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ABSTRACT Spontaneous binding of infected erythrocytes to uninfected erythrocytes to form rosettes is a property of some strains of Plasmodium falciparum that is linked to severe complications of malaria. Curdlan sulfate (CRDS) is a sulfated glycoconjugate compound that is chemically similar to known rosette-inhibiting drugs such as heparin. CRDS has previously been shown to have antimalarial activity in vitro and is safe for clinical use. Here we show that CRDS at therapeutic levels (10 to 100 μg/ml) significantly reduces rosette formation in vitro in seven P. falciparum laboratory strains and

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Mohaghegh, Fatemeh, Mina Saber, Parvin Rajabi, and Haniyeh Sohrabi. "Cutaneous Rosai-Dorfman Disease: A Report of 2 Cases and a Review of Recent Literature (2018–2023)." Case Reports in Dermatology 17, no. 1 (2025): 204–23. https://doi.org/10.1159/000546382.

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Introduction: Rosai-Dorfman disease (RDD) is a rare, benign histiocytic disorder that can present as isolated cutaneous RDD (CRDD), often mimicking other dermatologic conditions and complicating diagnosis. Case Presentation: We report two cases of CRDD: one with palms and soles involvement, and another as an exophytic facial mass, initially misdiagnosed and unsuccessfully treated. Dermoscopy revealed distinctive features, including yellow ovoid structures, linear vessels, and cotton-like white globules. Histopathological and immunohistochemical analyses confirmed CRDD with histiocytic infiltra

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Białowiec, Andrzej, Monika Micuda, Antoni Szumny, Jacek Łyczko, and Jacek Koziel. "Quantification of VOC Emissions from Carbonized Refuse-Derived Fuel Using Solid-Phase Microextraction and Gas Chromatography-Mass Spectrometry." Molecules 23, no. 12 (2018): 3208. http://dx.doi.org/10.3390/molecules23123208.

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In this work, for the first time, the volatile organic compound (VOC) emissions from carbonized refuse-derived fuel (CRDF) were quantified on a laboratory scale. The analyzed CRDF was generated from the torrefaction of municipal waste. Headspace solid-phase microextraction (SPME) and gas chromatography-mass spectrometry (GC-MS) was used to identify 84 VOCs, including many that are toxic, e.g., derivatives of benzene or toluene. The highest emissions were measured for nonanal, octanal, and heptanal. The top 10 most emitted VOCs contributed to almost 65% of the total emissions. The VOC mixture e

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Porretta, Alessandra P., Etienne Pruvot, and Zahurul A. Bhuiyan. "Calcium Release Deficiency Syndrome (CRDS): Rethinking “Atypical” Catecholaminergic Polymorphic Ventricular Tachycardia." Cardiogenetics 14, no. 4 (2024): 211–20. http://dx.doi.org/10.3390/cardiogenetics14040017.

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Since the first description of catecholaminergic polymorphic ventricular tachycardia (CPVT) in the 1970s, new insights have progressively unraveled the understanding of this inherited arrhythmia syndrome. The identification of new distinct clinical entities related to RYR2, the gene encoding the cardiac ryanodine receptor, has allowed significant refinement in the diagnosis of previously labeled “atypical” CPVT cases. Among RYR2-ryanodinopathies, the characterization of calcium release deficiency syndrome (CRDS) is still in its infancy and represents a diagnostic challenge due to the need for

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Liu, Zhilong, Tongxi Li, Zhifeng Zhu, Minggang Li, Changhua Nie, and Zhangchun Tang. "Noise Reduction Method for the Vibration Signal of Reactor CRDM Based on CEEMDAACN-SK." Electronics 12, no. 22 (2023): 4681. http://dx.doi.org/10.3390/electronics12224681.

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The reactor control rod drive mechanism (CRDM) controls the startup, shutdown and power of the reactor; it is one of the key pieces of equipment to ensure the normal operation of the reactor. CRDM is complex, mainly composed of stator, rotor, bearing, roller, etc. The characteristic analysis of the vibration monitoring signal is one of the important methods of the CRDM state evaluation. In view of the characteristics of large noise interference and the difficulty in analyzing the vibration monitoring signal of CRDM, this paper proposes a noise reduction method for the vibration signal of CRDM

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Branschädel, Marcus, Andrew Aird, Andrea Zappe, Carsten Tietz, Anja Krippner-Heidenreich, and Peter Scheurich. "Dual function of cysteine rich domain (CRD) 1 of TNF receptor type 1: Conformational stabilization of CRD2 and control of receptor responsiveness." Cellular Signalling 22, no. 3 (2010): 404–14. http://dx.doi.org/10.1016/j.cellsig.2009.10.011.

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Li, Weijiao, Yunpeng Wang, and Jingxue Yang. "Cloudy Region Drought Index (CRDI) Based on Long-Time-Series Cloud Optical Thickness (COT) and Vegetation Conditions Index (VCI): A Case Study in Guangdong, South Eastern China." Remote Sensing 12, no. 21 (2020): 3641. http://dx.doi.org/10.3390/rs12213641.

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Widespread and long-lasting drought disasters can aggravate environmental degradation. They can lead to significant economic losses and even affect social stability. The existing drought index mostly chose arid and semi-arid regions as study areas, because cloudy weather in humid and semi-humid regions hindered the satellite in its attempts to obtain the surface reflectivity. In order to solve this problem, a cloudy region drought index (CRDI) is proposed to estimate the drought of the clouded pixels. Due to the cumulative effect of drought, the antecedent drought index (ADI) has a certain imp

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Фечан, А. В., та Д. П. Кушнірук. "Оцінювання ефективності застосування CRDT-технологій у системах моніторингу інтернету речей". Scientific Bulletin of UNFU 34, № 4 (2024): 86–92. http://dx.doi.org/10.36930/40340411.

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Оцінено ефективність використання конфлікт-вільних реплікаційних структур даних CRDT (англ. Conflict-free Replicated Data Types), для забезпечення узгодженості та цілісності даних у системах моніторингу Інтернету речей (IoT). Виклики, пов'язані з моніторингом великої кількості розподілених IoT-пристроїв, вимагають ефективного управління даними, тому це дослідження розглядає технологію CRDT як альтернативу, що може спрощувати цей процес. CRDT-структури – це розподілені типи даних, які забезпечують сильну кінцеву узгодженість (англ. Strong Eventual Consistency, SEC), а також мають такі властивос

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Posa, Andreas, Izabela Niśkiewicz, Alexander Emmer, Frank Hanisch, and Malte E. Kornhuber. "Complex Repetitive Discharges: A Sign of Motor Axonal Reinnervation?" Brain Sciences 10, no. 6 (2020): 349. http://dx.doi.org/10.3390/brainsci10060349.

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Complex repetitive discharges (CRDs) are poorly understood phenomena in needle electromyography (EMG) recordings. The data presented here suggest that CRDs may mainly be a sign of motor unit reinnervation. EMG “video” data of 108 CRDs from neurogenic (ND, n = 39) and myogenic (MD, n = 14) disorders were retrospectively analyzed for cycle duration, potential-free time intervals, spike components (SC), maximum amplitudes, blockade, and increased jitter. CRD-SC in ND disorders (9.3 ± 7.8) outnumbered those in MD disorders (6.3 ± 6.2). The CRD cycle duration was correlated with SC and silent perio

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Mantha, Madhavi, Kevin M. Kubachka, John R. Urban, et al. "Economically Motivated Adulteration of Lemon Juice: Cavity Ring Down Spectroscopy in Comparison with Isotope Ratio Mass Spectrometry: Round-Robin Study." Journal of AOAC INTERNATIONAL 102, no. 5 (2019): 1544–51. http://dx.doi.org/10.1093/jaoac/102.5.1544.

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Abstract Background: Economically motivated adulteration (EMA) of foods has become an increasing concern in recent years, with lemon juice as a popular target. Objective and Method: In this work, an optimized preparation procedure for the isolation of citric acid from lemon juice was validated using elemental analyzer-isotope ratio MS (EA-IRMS) to detect adulteration with exogenous citric acid. Additionally, 69 imported lemon juice samples were evaluated using combustion module-cavity ring down spectrometry (CM-CRDS) and compared with the well-established EA-IRMS. Equivalency of CM-CRDS to EA-

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