Dissertations / Theses on the topic 'Creatura'
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Peters, Ana Paula. ""Nasce toda creatura com sua ventura"." reponame:Repositório Institucional da UFPR, 2013. http://hdl.handle.net/1884/33780.
Full textMastrodonato, Michela. "«Pietà per la creatura !» : Il sentimento del sacro nella poesia di Pier Paolo Pasolini." Thesis, Paris 4, 2013. http://www.theses.fr/2013PA040124.
Full textThe sense of a sacred vision deeply influences the poetry of Pasolini. This research paper confronts the fact that P. always saw himself as an atheist. It analyses his poetry in its chronological evolution, indicating how the first collections (La meglio gioventù and L’Usignolo della Chiesa Cattolica) are characterized by Christological visions and images. In Friuli, in a maternal landscape made up of “sacred appearances”, he discovers his homosexuality as a "guilty innocent", something not intentional and that prevents him from the communion with other creatures. For this sin, he asks to be heard, engaging in a biblical-theological dispute. His arrival in Rome opens a new phase: P. discovers the choral dimension of the Roman suburbs that breaks the previous isolation (Le ceneri di Gramsci). He stops asking for forgiveness and reviews the concept of sin that is not only internal, but also external, committed by the neo-capitalistic bourgeoisie who is both irreligious and “fascist”, preventing any single “creature” from being as it truly is. For every “creature”, unique and different from all the others, P. calls for mercy: «Pity the creature!» (La religione del mio tempo) and in the wake of the best humanistic tradition from Virgil to Dante onwards to Leopardi, he builds a sacred vision of reality which is inscribed into a philosophical horizon, not “creationist” but “creatural", in which God is felt rather than seen, like an eclipsed sun, a dimmed light whose source is impossible to see. A light which illuminates the last “creatures” (workers and all marginalized people), the incarnation of celestial dimension in human history (Trasumanar e organizzar)
Purser-Hallard, Philip. "The relationship between creator and creature in science fiction." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249858.
Full textRuiz, Quintana Ricardo. "NICOLÁS DE CUSA: LA CONCEPCIÓN DEL HOMBRE A PARTIR DE LO DIVINO." Tesis de Licenciatura, Universidad Autónoma del Estado de México, 2019. http://hdl.handle.net/20.500.11799/104478.
Full textVeniel, Jean-Claude. "Createurs, creatures et creation dans l'oeuvre de marcel ayme." Lille 3, 1988. http://www.theses.fr/1988LIL30012.
Full textMarcel ayme, an individualist, condemns all kinds of institutions and above all political ones, which exert their overwhelming power, depriving the individual of all freedom submerged as he is in the multitude. He rejects a materialistic civilization where man's soul vanishes and where the masks of social status are triumphant. Many a man, in his attempt to escape from a deceptive reality, indulges in imaginary paradises, in madness or death, since using the masks also impairs couple and family life. Therefore, the individual appears to be responsible for the pervading power of the mask. Indeed, he does not care much for truth which is as dangerous as lies. This stems from the fact that evil is, by nature, part of man as well as god and that sin is necessary for life. Thus, the writer invites us to accept creatures as they are and to remain hopeful. Throughout his spiritualistic quest, he throws off the yoke of reason, the legacy from the nineteenth century's intellectualism. He is urged to turn anew towards instinctive beliefs, the worship of the dead and of responsive gods. He endeavours to rediscover the roots of a faith which has never grown in him. His quest of god is the father's, it is that of his own identity which is reveales by the obsessional myth of twins. Because basic creativeness comes from the word which is god, its divine power wielded by the writer, leads him to find in himself the creator he was searching for, freer than god
Junior, Newton Ribeiro Rocha. "Creator and creature in William Gibson´s "Neuromancer": the promethean motif in science fiction." Universidade Federal de Minas Gerais, 2008. http://hdl.handle.net/1843/ECAP-7E2KKV.
Full textA busca humana do conhecimento é o núcleo principal do mito de Prometeus e da literatura de ficção científica (FC). A punição de Prometeus é um reflexo da natureza dupla do conhecimento: ele pode ser usado para o benefício ou a destruição da humanidade. A FC também lida com este tópico, representando a relação complexa entre a humanidade e o conhecimento através de várias formas: o encontro com culturas alienígenas, as conseqüências do desenvolvimento tecnológico e o confronto entre a civilização e suas criações. As obras de FC são representações contemporâneas do drama prometeico, especialmente nas narrativas que lidam com a relação entre criadores e criaturas. Esta relação é uma reação ao que Hans Blumenberg chama de absolutistmo da realidade, a crença da humanidade de que não pode controlar completamente as condições de sua existência. O drama do criador versus a criatura na FC evolve através de uma progressiva seleção de narrativas que procura dar ao mito de Prometeus uma interpretação final. Da monstruosa criatura do Frankenstein, de Mary Shelley até as inteligências artificiais com características divinas presentes em Neuromancer, de William Gibson, a relação entre o criador e criatura na FC desenvolveu-se em novas e complexas configurações. O subgênero cyberpunk da FC tenta superar a dicotomia entre o criador e a criatura através da humanização da criatura e da objetificação da identidade humana, sumarizada na figura do ciborgue. A literatura cyberpunk contemporânea unifica a humanidade e suas máquinas em uma existência pós-humana, na qual a diferença entre consciências orgânicas e artificiais são esquecidas. Assim, o mito de Prometeus se transforma em uma busca pela identidade de seres que são ao mesmo tempo criadores e criaturas.
Sonoquie, Neesa. "Lucky Creature." PDXScholar, 2013. https://pdxscholar.library.pdx.edu/open_access_etds/1013.
Full textFlouton, Emily Suzanne. "Creature of Detours." PDXScholar, 2018. https://pdxscholar.library.pdx.edu/open_access_etds/4561.
Full textHarley, James. "Analysis of Cantico delle Creature." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=41606.
Full textMueller, Johanna. "Creature alterations, myth & transformations." Fairfax, VA : George Mason University, 2009. http://hdl.handle.net/1920/4568.
Full textVita: p. 72. Thesis director: Helen Frederick. Submitted in partial fulfillment of the requirements for the degree of Master of Fine Arts in Art and Visual Technology. Title from PDF t.p. (viewed Oct. 11, 2009). Includes bibliographical references (p. 69-71). Also issued in print.
Angle, Colin M. (Colin McKay). "Design of an artificial creature." Thesis, Massachusetts Institute of Technology, 1991. http://hdl.handle.net/1721.1/13947.
Full textBober, Nicholas Bradburn. "This Creature, Bride of Christ." Thesis, University of North Texas, 2010. https://digital.library.unt.edu/ark:/67531/metadc28395/.
Full textMcCormick, Gordon. "Hospital: A Creature of Duality." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3392.
Full textWightman, Shaun. "PITIFUL CREATURES." Master's thesis, University of Central Florida, 2008. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4188.
Full textM.F.A.
Department of Art
Arts and Humanities
Studio Art and the Computer MFA
McRae, Madalyn Dawn. "Pop Creatures." BYU ScholarsArchive, 2020. https://scholarsarchive.byu.edu/etd/8752.
Full textAlison, Cheryl. "Creatures of Habit." Thesis, Tufts University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3624685.
Full textThis dissertation contends that the kinds of consistency composition both affords and demands in order to hold together as a composition have a special location within European and American late modernism. In the decades surrounding the Second World War, artists acknowledged that art needed to let in disorder to reflect lived experience; yet, it still had to cohere in order to be recognizable as art, or a form of presentation. Paying attention to how diverse late modernist artists were thus creatively challenged, I argue that their works of art demonstrate historically located and informed compositional conservatism, or formal rigidity. Making the case for the breadth of composition's organizing force during the period, I focus on a different artist and disciplinary area in each of three chapters: Francis Bacon's oil paintings, Samuel Beckett's dramatic and theatrical work in Endgame, and Ralph Ellison's novelistic efforts in Invisible Man and his unfinished second manuscript.
Late modernist artwork exercises formal control in ways extreme enough to be called violent. But if "violence" signifies here how formal control stringently orders components (and excludes others) to bring them into line with composition's demands, this formal signification hardly removes such violence from having lived consequences. More, such components' failure to fall into line, or the artist's failure to accomplish such organization, can itself have unfortunate repercussions. Building on Gilles Deleuze and Félix Guattari's art theory, which lays the groundwork for aligning apparently dissimilar compositions, I argue that in Bacon, Beckett, and Ellison, compositional force operates in ways shared by larger physical and psychological arrangements. I show how not just home or domestic spaces, but also national and political structures, including, e.g., those defining German fascism, partake in composition's formational activities. Making use of conceptual apparatuses that extend beyond Deleuzoguattarian theory to include psychoanalysis and Frankfurt School theorists, this dissertation examines how the violence (and pleasure) of form variously subtends the period's configurations.
Galdos, Gonzalo. "La tensión creativa." Universidad Peruana de Ciencias Aplicadas (UPC), 2013. http://hdl.handle.net/10757/285407.
Full textSharpe, Lynne. "Creatures like us?" Thesis, University of Wales Trinity Saint David, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.683188.
Full textRich, Coralmarie Louise. "Creator Unknown." Kent State University Honors College / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1305121478.
Full textConnell, Jonathan H. "A colony architecture for an artificial creature." Thesis, Massachusetts Institute of Technology, 1989. http://hdl.handle.net/1721.1/111562.
Full textIncludes bibliographical references (leaves 168-172).
by Jonathan Hudson Connell.
Ph.D.
Foreman, Elizabeth Wolf Susan R. "Focusing respect on creatures." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,1726.
Full textTitle from electronic title page (viewed Sep. 16, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Philosophy." Discipline: Philosophy; Department/School: Philosophy.
Giragosian, Sarah. "Queer creatures, queer times." Thesis, State University of New York at Albany, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3633190.
Full textQueer Creatures, Queer Times makes a critical intervention in queer theory and queer poetics through a combination of critical and creative approaches to explore how posthumanist thought and animal studies might correct a blindspot in current critical work on queer experience and texts. Queer theory tends to neglect non/human subjects, yet an ecological and posthumanist critique helps to trouble its humanist bias as well as its overly neat ties to constructivist and performative notions of selfhood. I argue that modern lyric poetry, in emergence during the cultural transmission of Darwinian precepts and the social invention of the homosexual, is uniquely situated to challenge the exclusivist principles that underlie specieisim, Social Darwinism, and heterosexism. While queer theory tends to overlook evolution in the construction of subjectivity and sexuality, I posit that such tendencies diminish opportunities for thinking through non-coherent selfhood and the radical contingency of beings upon other life forms. Accompanying my critical essays on three modernist queer poets, Djuna Barnes, Elizabeth Bishop, and Marianne Moore, are my poetics essay entitled "Towards a Poetics of the Animal" and my poetry manuscript Queer Fish. Both poetic texts explore non-dominant forms of queer relation between animals and humans.
Needham, Sarah Jane. "Creatures, fabrics and minerals." Thesis, University of Liverpool, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426129.
Full textAlberto, Jimenez Cisneros Luis, and Denegri Alvarez Calderon Paola. "Fotografía Creativa-DG15-201701." Universidad Peruana de Ciencias Aplicadas (UPC), 2017. http://hdl.handle.net/10757/635520.
Full textAlberto, Jimenez Cisneros Luis. "Fotografía Creativa-DG15-201802." Universidad Peruana de Ciencias Aplicadas (UPC), 2018. http://hdl.handle.net/10757/635522.
Full textAlberto, Jimenez Cisneros Luis. "Fotografía Creativa-DG15-201401." Universidad Peruana de Ciencias Aplicadas (UPC), 2014. http://hdl.handle.net/10757/635518.
Full textAlberto, Jimenez Cisneros Luis. "Fotografía Creativa-DG15-201501." Universidad Peruana de Ciencias Aplicadas (UPC), 2015. http://hdl.handle.net/10757/635519.
Full textAlberto, Jimenez Cisneros Luis. "Fotografía Creativa-DG15-201702." Universidad Peruana de Ciencias Aplicadas (UPC), 2017. http://hdl.handle.net/10757/635521.
Full textAlexis, Hosoya Komatsudani Aaron, Gonzalez Meneses Jana, Jimenez Cisneros Luis Alberto, and Guerra Rivero Renzo. "Fotografía Creativa-DG15-201901." Universidad Peruana de Ciencias Aplicadas (UPC), 2019. http://hdl.handle.net/10757/635523.
Full textAertsen, Johannes Adrianus. "Nature and creature : Thomas Aquinas's way of thought /." Leiden ; New York ; Köln : E. J. Brill, 1988. http://catalogue.bnf.fr/ark:/12148/cb34951252j.
Full textWebb, Kathleen. "Creature of the Night: The Changing Image of Dracula." Miami University Honors Theses / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=muhonors1110919620.
Full textBurris, Andrea. "Creature comforts : an exploration of comfort in the home." Thesis, Loughborough University, 2014. https://dspace.lboro.ac.uk/2134/16314.
Full textLucas, Sátiro María Angélica. "Pedagogía para una ciudadanía creativa." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/96169.
Full textThis is a Thesis by Publication which seeks to provide a themed unit of ten articles published in referred books and journals as well as two books which result from investigation. These texts which have been published in five countries (Spain, Brazil, Mexico, Argentina and Guatemala) are evidence of a trajectory of research effort that commenced in the 1980’s. The issue which provoked this investigation was the question of creative capacity and its ethical, social and civic potential, applied to education in its broadest sense. Over the years a praxis, which has proposed various practices and ideas, has been created around the possible relationships between these thematic areas. The texts of this compendium represent thoughtful opinions about this praxis and were published between 2002 and 2012. This Thesis proposes pedagogy for the development of creative citizens. It seeks to develop resourceful individuals and groups, capable of creating original "products" through imaginative process in order to create societies which are prepared to face the challenges of the XXI century. It is based on the principle that nobody is taught to be a creative citizen, rather the conditions can be provided to allow them to learn to become one. For this the issue of systemic interaction between the following four basic elements is raised: the person, the process, the environment and the creative product. From this perspective is it the educational field that has the opportunity to favour the emergence of creative citizens. That is, it is the educational environment that encourages individuals and collectives to become enabled to use social evolution against current challenges. This process can become evident as actions and interactions that are coherent with a way of being and thinking on citizenship are favoured (creative ethos). So, the thematically unifying element of this compendium is an understanding of education as a systemic creative process. This Thesis is accompanied by the Ciudadanía Creativa website (www.crearmundos.net/tesis) where the elements of the compendium are expanded with quantitative and qualitative evidence of the projects quoted in the articles.
Burris, Sarah M. "Creatures series of sculptural costumes /." [Kent, Ohio] : Kent State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1227280056.
Full textTitle from PDF t.p. (viewed Jan. 5, 2010). Advisor: Paul O'Keeffe. Keywords: sculpture, performance, fabric, beauty, sewing, feminine. Includes bibliographical references (p. 28).
Burris, Sarah Mittiga. "Creatures: Series of Sculptural Costumes." Kent State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=kent1227280056.
Full textKeable, Penelope Susan. "Creators, Creatures and Victim-Survivors: Word, Silence and Some Humane Voices of Self-Determination from the Wycliffe Bible of 1388 to the United Nations World Conference on Human Rights 1993." University of Sydney, Religion, 1995. http://hdl.handle.net/2123/407.
Full textYohanan, Steven John. "The Haptic Creature : social human-robot interaction through affective touch." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43144.
Full textMorgan, Matt. "CREATURE COMFORT: ANTHROPOMORPHISM, SEXUALITY, AND REVITALIZATION IN THE FURRY FANDOM." MSSTATE, 2008. http://sun.library.msstate.edu/ETD-db/theses/available/etd-04042008-164344/.
Full textRay, Corey Carpenter. "Understanding the ancient Egyptians : an examination of living creature hieroglyphs." Thesis, Stellenbosch : Stellenbosch University, 1999. http://hdl.handle.net/10019.1/51538.
Full textENGLISH ABSTRACT: In this thesis an exploration is made into whether or not hieroglyphs reflect ideas of the ancient Egyptians themselves. By examining "living creature" hieroglyphs one may contemplate why the ancient Egyptian chose a particular manner of depiction. The manner of depiction can then be examined insofar as what ideas they may reflect. In this way study into other groups of signs such as those of the environment may be used to further illuminate the lives and our understanding of the ancient Egyptian(s). This thesis begins with an examination of both the problem inherent in such a task and an overview of some of the "processes" involved. By understanding that a reconstructed reality, that of the hieroglyph, reflects both real and perceived characteristics represented in glyphic form, one may seek out the mental impressions considered relevant to the people themselves. Next the role literacy played and still plays is discussed. This discussion includes a brief historical overview of both the history of decipherment and the "language" of the ancient Egyptians. The importance of "writing", artistic in nature in Egypt in regards to hieroglyphs, is then discussed as it relates to its use as symbol. Hieroglyphs are then discussed in their role as art, communication, and language emphasizing the multitudinous role(s) which they served. The importance is thus reiterated that hieroglyphs served as a communication of ideas to both the literate and the "illiterate" in at least a menial manner. After providing a "background" context of both the world and time of hieroglyphs and their subsequent "understanding" and interpretation, there is an analysis of the hieroglyphs for living creatures including the following Gardiner groupings: (1) mammals, (2) birds, (3) amphibians and reptiles, (4) fish, (5) invertebrates and lesser animals. The signs are examined in regards to their function and variations followed by some observations and comments related to the "structure" and perspective of the sign itself. Summary observations and comments are then made about each group. The thesis is then brought full circle by examining the implications of what hieroglyphs can tell us about the ancient Egyptians, via the perceptive and communicative role which they played. By understanding hieroglyphs as "fingerprints" of/from the mind of the people and subsequently their culture, this framework may provide a new mechanism into understanding the Egyptian via their own visualization and perceptive nature. A case is then proposed that this new "mechanism", if it is indeed considered feasible, can be applied to not only the physical world consisting of nature such as the environment, but also to groups which depict manmade objects.
AFRIKAANSE OPSOMMING: In hierdie tesis is die moontlikheid ondersoek dat hierogliewe iets van die ideewereld van die antieke Egiptenare reflekteer. In die bestudering van "lewende wese" hierogliewe kom vrae op soos waarom die antieke Egiptenare juis 'n spesifieke vorm van voorsteIIing verkies het. Die vorm van voorsteIIing kan dan bestudeer word vir die idees wat dit moontlik mag reflekteer. Ander groepe/velde van tekens, soos die van die breër omgewing, kan gebruik word om verdere lig te werp op die lewe van die antieke Egiptenaar(e) en ons verstaan daarvan. Die tesis begin met 'n bestudering van die inherente probleme in die aanpak van so 'n taak en 'n oorsig oor sommige van die "prosesse" daarby betrokke. By die verstaan van die hieroglief as 'n gekonstrueerde realiteit, wat weklike sowel as afgeleide eienskappe reflekteer, ontdek die ondersoeker daarvan iets van die persoonlike/kulturele indrukke wat deur hierdie groep mense as relevant ervaar is. In die volgende afdeling kom die rol van geletterdheid aan die beurt. Hierdie bespreking sluit 'n bondige historiese oorsig oor die geskiedenis van ontsyfering asook die taal van die Egiptenare in. Die belang van die "skryfkuns" en veral die kunsaard daarvan in die Egiptiese hierogliewe word vervolgens bespreek. Dit is veraI waar soos dit in verhouding staan met die gebruik daarvan as simbool. Die veelsydige rol(le) en belang van hierogliewe in die kuns, kommunikasie en taal word dan ondersoek en bespreek. Die klem word daarop gelê dat hierogliewe as die kommunikasie van idees aan beide die geletterde en "ongeletterde" dien. Nadat 'n agtergrondkonteks van die wereld en tyd van die hierogliewe en die daaruitvloeiende "verstaan" en interpretasie daarvan gegee is, word 'n analise van die "lewende wese" hierogliewe gedoen. Dit sluit die volgende groeperinge van Gardiner in: (1) soogdiere, (2) voels, (3) amfibiee en reptiele, (4) visse, (5) invertebrata en kleiner diere. Hierdie hierogliewe word ondersoek in terme van hulle funksie en variasies, gevolg deur waarnemings en opmerkings aangaande die "struktuur" en die perspektief van die teken. Opsommende observasies en enkele opmerkings oor elke groep volg daarna. Die tesis word afgerond met 'n ondersoek na die implikasies van wat ons kan wys word uit die hierogliewe aangaande die antieke Egiptenare, via die perspektiwiese en kommunikatiewe rol wat dit vervuI. Deur hierogliewe te verstaan as die "vingerafdrukke" van die begrip van hierdie mense kan hierdie raamwerk 'n nuwe meganisme in die verstaan van die Egiptenaar via die visualisasie en waarneembare aard daarvan, vorm. 'n Voorstel word gemaak dat hierdie nuwe "meganisme", indien dit uitvoerbaar is, toegepas kan word, nie net op die hierogliewe van die fisiese wereld bestaande uit die natuur en die omgewing nie, maar ook op hierogliewe wat mensgemaakte voorwerpe voorstel.
SALES, MARIA LEILA. "REFUGE, ADDRESS UNFINISHED CREATURE: RECOGNITION AND RIGHTS OF DISPLACED PEOPLE." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2013. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=23901@1.
Full textCOORDENAÇÃO DE APERFEIÇOAMENTO DO PESSOAL DE ENSINO SUPERIOR
PROGRAMA DE SUPORTE À PÓS-GRADUAÇÃO DE INSTS. DE ENSINO
O presente texto tem como objetivo relatar o universo do refúgio na cidade do Rio de Janeiro; analisando os fatores socioeconômicos e culturais que permeiam o movimento de entrada e permanência dessa população no município. Aborda principalmente questões relativas aos direitos humanos, problematizando ao mesmo tempo, sua existência por vezes abstrata, fator que dificulta a inserção dos deslocados na sociedade, aumentando com isso, as fraturas existentes entre eles e o Estado-Nação. Fez-se uma tentativa no sentido de compreender quais os lugares ocupados pelos deslocados nessa nova territorialidade em que se privilegia o fim das limitações comerciais e econômicas, garantindo livre fluxo de capitais em detrimento do próprio fluxo da vida humana.
This text is intended to provide a report on the refuges universe in Rio de Janeiro by analyzing social, economic and cultural aspects which permeate the motion and permanence of this population. It approaches questions concerning the human rights, arguing at the same time its own existence, sometimes abstract, which makes difficult the social insertion of the refugees and increases the rupture between this social group and the state-nation. There was an attempt to understand the places occupied by the refugees in this new territoriality where the end of commercial and economic limitations and the free flow of capital is encouraged rather of the flow of human life.
Brostow, Gabriel Julian. "Novel Skeletal Representation for Articulated Creatures." Diss., Georgia Institute of Technology, 2004. http://hdl.handle.net/1853/5236.
Full textSolomon, Gabriel Jerome. "Computer animation of multi-legged creatures." Thesis, Georgia Institute of Technology, 1993. http://hdl.handle.net/1853/9192.
Full textBainbridge, Christopher James. "Digital control networks for virtual creatures." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4812.
Full textCaminati, Angela. "La metafora: forma creativa di razionalità." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/11358/.
Full textCunha, Maurício Peña. "Efeito antidepressivo e neuroprotetor da creatina." reponame:Repositório Institucional da UFSC, 2013. https://repositorio.ufsc.br/handle/123456789/107086.
Full textMade available in DSpace on 2013-12-05T23:10:39Z (GMT). No. of bitstreams: 1 320906.pdf: 3852058 bytes, checksum: f76b24f3a609281787c0890e932c2090 (MD5) Previous issue date: 2013
A creatina modula a bioenergética celular e apresenta efeito antiexcitotóxico, antioxidante e apresenta propriedades neuroprotetora e antidepressiva, no entanto, os mecanismos intracelulares responsáveis por esses efeitos ainda não estão bem estabelecidos. No primeiro captítulo desta tese foi analisado o efeito da administração de creatina (p.o.) em camundongos no teste de suspensão pela cauda (TSC), um teste preditivo de atividade antidepressiva. Além disso, foi avaliado o envolvimento dos sistemas de neurotransmissão dopaminérgico, serotonérgico, noradrenérgico, glutamatérgico, bem como as vias de sinalização intracelular mediadas por L-arginina/óxido nítrico (ON), proteína cinase A (PKA), proteína cinase C (PKC), cinase da cinase ativada por mitógenos (MEK)/cinase ativada por estímulos extracelulares (ERK) 1/2, cinase dependente de Ca2+/calmodulina (CaMK-2), fosfatidilinositol 3 cinase (PI3K)/proteína cinase B (AKT), glicogênio sintase cinase 3ß (GSK-3ß), proteína alvo da rapamicina em mamíferos (mTOR) e hemeoxigenase-1 (HO-1) implicadas no efeito antidepressivo da creatina no TSC. A administração de creatina (0,1-1000 mg/kg) reduziu o tempo de imobilidade em camundongos submetidos ao TSC, sem alterar a atividade locomotora. O efeito anti-imobilidade promovido pela administração de creatina no TSC foi bloqueado pelo pré-tratamento dos camundongos com ?-clorofenilalanina metil éster (PCPA; 100 mg/kg, i.p., por 4 dias consecutivos, inibidor da síntese de serotonina (5-HT)), a-metil-?-tirosina (AMPT; 100 mg/kg, i.p., inibidor da enzima tirosina hidroxilase), haloperidol (0,2 mg/kg, i.p., antagonista não seletivo de receptores dopaminérgicos), SCH23390 (0,05 mg/kg, s.c., antagonista de receptores dopaminérgicos D1), sulpirida (50 mg/kg, i.p., antagonista de receptores dopaminérgicos D2), prazosina (1 mg/kg, i.p., antagonista de receptores a1-adrenérgicos), N-metil-D-aspartato (NMDA) (0,1 pmol/sítio, i.c.v.), D-serina (30 µg/sítio, i.c.v., agonista do sítio da glicina do receptor NMDA), arcaína (1 mg/kg, i.p., antagonista do sítio das poliaminas dos receptores NMDA), L-arginina (750 mg/kg, i.p., precursor de ON), SNAP (25 µg/site, i.c.v, doador de ON), 7-nitroindazol (25 mg/kg, i.p., inibidor da enzima óxido nítrico sintase neuronal), H-89 (1 µg/sítio, i.c.v., inibidor de PKA), KN-62 (1 µg/sítio, i.c.v., inibidor de CaMK-2), queleritrina (1 µg/site, i.c.v., inibidor de PKC), U0126 (5 µg/sítio, i.c.v., inibidor de MEK1/2), PD09058 (5 µg/sítio, inibidor da MEK1/2), LY294002 (10 nmol/sítio, i.c.v., inibidor de PI3K), wortmanina (0,1 µg/sítio, inibidor de PI3K), rapamicina (0,2 nmol/sítio, i.c.v., inibidor de mTOR), protoporfirina de zinco (10 µg/sítio, i.c.v., inibidor da enzima heme oxigenase-1). Alémdisso, creatina (0,01 mg/kg, dose sub-efetiva) em combinação com doses sub-efetivas de SKF38393 (0,1 mg/kg, s.c., agonista de receptores dopaminérgicos D1), apomorfina (0,5 mg/kg, ip, agonista preferencial de receptores dopaminérgicos D2), fenilefrina (0,4 µg/sítio, i.c.v., agonista de receptores a1-adrenérgico), WAY100635 (0,1 mg/kg, s.c., antagonista seletivo de receptores 5-HT1A), 8-OH-DPAT (0,1 mg/kg, i.p., agonista de receptores 5-HT1A), fluoxetina (5 mg/kg, p.o., antidepressivo inibidor da recaptação de serotonina (ISRS)), paroxetina (0,1 mg/kg, p.o., ISRS), citalopram (0,1mg/kg, p.o., ISRS), sertralina (3 mg/kg, p.o., ISRS), amitriptilina (1 mg/kg, p.o., antidepressivo tricíclico), imipramina (0,1 mg/kg, p.o., antidepressivo tricíclico), reboxetina (2 mg/kg, p.o., antidepressivo inibidor seletivo da recaptação de noradrenalina, ISRN), bupropiona (1 mg/kg, p.o., antidepressivo inibidor da recaptação de dopamina e noradrenalina), MK-801 (0,01 mg/kg, p.o., antagonista de receptores de NMDA), cetamina (0,1 mg/kg, i.p., antagonista de receptores NMDA), AR-A014418 (0,01 µg/sítio, i.c.v., inibidor seletivo da enzima GSK-3ß), cloreto de lítio (10 mg/kg, p.o., inibidor não seletivo da enzima GSK-3ß), protoporfirina de cobalto (0,01 µg/sítio, i.c.v., indutor da expressão de HO-1) reduziu o tempo de imobilidade no TSC, em comparação com qualquer um dos fármacos administrados isoladamente. Este conjunto de resultados sugere que o efeito antidepressivo da creatina no TSC seja mediado por uma ativação de receptores dopaminérgicos D1 e D2, bem como dos receptores 5-HT1A e a1-adrenérgico, e uma inativação de receptores glutamatérgicos NMDA, além de envolver a ativação de PKA, PKC, MEK1/2, PI3K/AKT, mTOR, HO-1 e uma inibição de GSK-3ß. Tendo em vista que existe uma grande comorbidade entre a depressão e a doença de Parkinson (DP), e sabendo que antidepressivos de distintas classes protegem da morte celular induzida por toxinas dopaminérgicas, como a 6-OHDA, o segundo capítulo desta tese investigou o efeito neuroprotetor da creatina frente a morte celular induzida pela toxina dopaminérgica 6-OHDA. Esta diminuiu a viabilidade de células de neuroblastoma humano SH-SY5Y, bem como de fatias de estriado cerebral de ratos. A creatina apresentou um efeito protetor contra a toxicidade induzida por 6-OHDA (10?5000 µM) em células SH-SY5Y e este efeito foi revertido por diferentes inibidores de cinases: LY294002 (10 µM), KN-93 (1 µM, inibidor de CaMK-2), H-89 (2 µM), PD98059 (10 µM) e queleritrina (0,1 µM). Além disso, 6-OHDA reduziu a fosforilação de GSK-3ß (Ser9) em células SH-SY5Y e a incubação com creatina reverteu este efeito. Ainda, 6-OHDA (50-300 µM) reduziu a viabilidade celular em fatias de estriado de ratos e creatina ou fosfocreatina (2,5-10 mM) reverteueste efeito. Ainda, verificamos que 6-OHDA aumenta a produção de espécies reativas de oxigênio e induz uma diminuição na fosforilação de AKT (Ser473) e GSK-3ß (Ser9) em fatias de estriado de ratos, sendo que a creatina ou fosfocreatina (5 mM) reverteu este efeito. O inibidor da PI3K LY294002 (30 µM) reverteu o efeito da creatina e da fosfocreatina sobre a viabilidade celular e produção de espécies reativas de oxigênio em fatias de estriado expostas a 6-OHDA. Além disso, 6-OHDA diminuiu o imunoconteúdo de tirosina hidroxilase e creatina ou fosfocreatina reverteu este efeito. O efeito protetor de creatina ou fosfocreatina na modulação do imunoconteúdo de tirosina hidroxilase em fatias de estriado de ratos expostas a 6-OHDA parece ser dependente da ativação da via de sinalização intracelular PI3K/AKT, uma vez que LY294002 (30 µM) reverteu este efeito. Este segundo conjunto de resultados sugere que a creatina apresenta efeito neuroprotetor frente à morte celular induzida por 6-OHDA e este efeito parece ser devido a propriedades antioxidantes e ativação das vias de sinalização intracelular mediadas por PKA, PKC, MEK1/2, PI3K/AKT e uma inibição de GSK-3ß. Esta tese sugere que a creatina pode ser uma nova alternativa terapêutica para o tratamento da depressão e da DP.
Abstract : Creatine modulates cellular bioenergetics and presents antiexcitotoxic, antioxidant, neuroprotective and antidepressant properties; however, the intracellular mechanisms responsible for these effects are not well established. In the first chapter of this thesis, the effect of creatine administration (p.o.) in the mouse tail suspension test (TST), a test predictive of antidepressant activity, was investigated. In addition, the possible involvement of neurotransmission systems (dopaminergic, serotonergic, noradrenergic and glutamatergic), and the intracellular signaling pathways mediated by L-arginine/nitric oxide (NO), protein kinase A (PKA), protein kinase C (PKC), mitogen-activated protein kinase kinase 1/2 (MEK 1/2)/ extracellular-signal-regulated kinase 1/2 (ERK 1/2), Ca2+/calmodulin-dependent protein kinase-2 (CaMK-2), phosphatidylinositide 3-kinase (PI3K)/protein kinase B (AKT), glycogen synthase kinase-3ß (GSK-3ß), mammalian target of rapamycin (mTOR) and heme oxygenase-1 (HO-1) in the antidepressant-like effect of creatine in the TST was evaluated. The administration of creatine (0.1-1000 mg/kg) reduced the immobility time in mice submitted to the TST, without changing locomotor activity. The anti-immobility effect of creatine in the TST was blocked by pretreatment of mice with p-chlorophenylalanine methyl ester (PCPA; 100 mg/kg, i.p., for 4 consecutive days, inhibitor of serotonin (5-HT) synthesis), a-methyl-p-tyrosine (AMPT, 100 mg/kg, i.p., inhibitor of tyrosine hydroxylase), haloperidol (0.2 mg/kg, i.p., non-selective dopamine receptor antagonist), SCH23390 (0.05 mg/kg, s.c., dopamine D1 receptor antagonist), sulpiride (50 mg/kg, i.p., dopamine D2 receptor antagonist), prazosin (1 mg/kg, i.p., a1-adrenoceptor antagonist), NMDA (0.1 pmol/site, i.c.v.), D-serine (30 µg/site, i.c.v., agonist of the glycine site of the NMDA receptor), arcaine (1 mg/kg, i.p., antagonist of the polyamine site of the NMDA receptor), L- arginine (750 mg/kg, i.p., a precursor of nitric oxide, NO), SNAP (25 µg/site, i.c.v., NO donor), 7-nitroindazole (25 mg/kg, i.p., inhibitor of neuronal nitric oxide synthase), H-89 (1 µg/site, i.c.v., PKA inhibitor), KN-62 (1 µg/site, i.c.v., CaMK-2 inhibitor), chelerythrine (1 µg/site, i.c.v., PKC inhibitor), U0126 (5 µg/site, i.c.v., MEK1/2 inhibitor), PD09058 (5 µg/site, MEK1/2 inhibitor), LY294002 (10 nmol/site, i.c.v., PI3K inhibitor), wortmannin (0.1 µg/site, PI3K inhibitor), rapamycin (0.2 nmol/site, i.c.v., mTOR inhibitor), zinc protoporphyrin (10 µg/site, i.c.v., HO-1 inhibitor). Furthermore, creatine (0.01 mg/kg, sub-effective dose) in combination with sub-effective doses of SKF38393 (0.1 mg/kg s.c., dopamine D1 receptor agonist), apomorphine(0.5 mg/kg, i.p., preferential agonist of dopamine D2 receptor), phenylephrine (0.4 mg/site, i.c.v., a1-adrenoceptor agonist), WAY100635 (0.1 mg/kg, s.c., a selective 5-HT1A receptor antagonist) 8-OH-DPAT (0.1 mg/kg, i.p., a selective 5-HT1A receptor agonist), fluoxetine (5mg/kg, p.o., selective serotonin reuptake inhibitor (SSRI)), paroxetine (0.1 mg/kg, p.o., SSRI), citalopram (0.1 mg/kg, p.o., SSRI), sertraline (3 mg/kg, p.o., SSRI), amitriptyline (1 mg/kg p.o., tricyclic antidepressant), imipramine (0.1 mg/kg, p.o., tricyclic antidepressant), reboxetine (2 mg/kg, p.o., selective noradrenaline reuptake inhibitor), bupropion (1 mg/kg, p.o., dopamine and noradrenaline reuptake inhibitor), MK-801 (0.01 mg/kg, p.o., NMDA receptor antagonist) ketamine (0.1 mg/kg, i.p., NMDA receptor antagonist), AR-A014418 (0.01/site, i.c.v., GSK-3ß inhibitor), lithium chloride (10 mg/kg, p.o., non-selective GSK-3ß inhibitor), cobalt protoporphyrin (0.01 µg/site, i.c.v., inducer of HO-1 expression) decreased the immobility time in the TST as compared to either drug administered alone. This set of results suggest that the antidepressant-like effect of creatine in the TST is mediated by the activation of dopamine D1 and D2 receptors, 5-HT1A receptors, and a1-adrenoceptors as well as an inactivation of NMDA receptors. Moreover, this set of results also indicates that activation of PKA, PKC, MEK1/2, PI3K/AKT, mTOR, HO-1 and inhibition of GSK-3ß are involved in the antidepressant-like effect of creatine in the TST. Considering: i) the high depression and Parkinson's disease comorbidity; ii) antidepressants of different classes protect the cell death induced by dopaminergic toxins, such as 6-OHDA, the second chapter of this thesis also evaluated the neuroprotective effect of creatine against cell death induced by the dopaminergic toxin 6-OHDA. We demonstrated that 6-OHDA decreased the cell viability of human neuroblastoma cells SH-SY5Y, as well as rat striatal slices. Creatine protected against the toxicity induced by 6-OHDA (10-5000 mM) in SH-SY5Y cells and this effect was reversed by different kinase inhibitors: LY294002 (10 µM), KN-93 (1 µM, CaMK-2 inhibitor), H-89 (2 µM), PD98059 (10 µM) and chelerythrine (0.1 µM). Furthermore, 6-OHDA reduced phosphorylation of GSK-3ß (Ser9) in SH-SY5Y cells and creatine (10 µM) reversed this effect. Also, 6-OHDA (50-300 µM) reduced cell viability and increased the production of reactive oxygen species in rat striatal slices and creatine or phosphocreatine (2.5-10 mM) reversed this effect. We also find that 6-OHDA decreased the phosphorylation of AKT (Ser473) and GSK-3ß (Ser9) in rat striatal slices and creatine or phosphocreatine reversed this effect. The PI3K inhibitor LY294002 (30 mM) reversed the protective effect of creatine or phosphocreatine against cell viability and production of reactive oxygenspecies in striatal slices exposed to 6-OHDA. Furthermore, 6-OHDA decreased the tyrosine hydroxylase immunocontent and phosphocreatine or creatine reversed this effect. The effect of creatine or phosphocreatine on the modulation of tyrosine hydroxylase immunocontent in rat striatal slices exposed to 6-OHDA could be dependent on the activation of the intracellular signaling pathway mediated by PI3K/AKT, since LY294002 (30 mM) reversed this effect. This second set of data suggests that creatine has neuroprotective effect against cell death induced by 6-OHDA and this effect could be due to the antioxidant properties and activation of intracellular signaling pathways mediated by PKA, PKC, MEK1/2, PI3K/AKT and an inhibition of GSK-3ß. This thesis suggests that creatine may be a novel therapeutic alternative for the treatment of depression and Parkinson's disease.
Richard, du Perron Stéphane. "Le symbolisme du dieu-createur potier." Paris 4, 1987. http://www.theses.fr/1987PA040025.
Full textThe symbol of potter-god, studied in its ancient mythological manifestations (antic civilisations of mesopotamia, egypt and israel) and in its modern literary extensions, may make evident a disregarded symbolicscheme, wich is expressed by a collection of materials, a combination of gestures and relations woven by the divine modellers at the very moment of creation. The extent of that image, in the variety of its expressions, is the source of its remarkable universalism
Barrera, Verdugo Daniela, Marambio Lorena Jara, Albarrán Cristina Reyes, and Piccardo Alejandro Vásquez. "Un análisis de la contabilidad creativa." Tesis, Universidad de Chile, 2003. http://www.repositorio.uchile.cl/handle/2250/111516.
Full textEl presente trabajo se propone analizar el fenómeno conocido como “Contabilidad Creativa”, que estuvo presente durante largo tiempo desde el conocimiento público de los llamados escándalos financieros, en donde grandes empresas se vieron involucradas en irregularidades en su contabilidad. Con ello se pretende retomar el tema en nuestro país, por cuanto ha pasado un poco al olvido por parte de la opinión pública, no así para las empresas ya que han debido preocuparse por las nuevas normativas que las afectan. La mayoría de los usuarios de la contabilidad están convencidos de que tiende a ser una materia exacta, es decir, que refleja fielmente una imagen de la realidad. Sin embargo, los principios y normas contables existentes permiten elegir entre diversas alternativas, lo que posibilita elegir la más conveniente y que proyecte lo que se desea y es aquí donde aparece la llamada Contabilidad Creativa, que se utiliza comúnmente para describir el proceso mediante el cuál los contadores utilizan su conocimiento de las normas contables para manipular las cifras incluidas en las cuentas de una empresa, aprovechándose de los vacíos de la normativa existente, y de las posibles elecciones entre diferentes prácticas de valoración que ésta ofrece.
Figueroa, Diego, and Keating Eduardo Vea. "El renacimiento de la independencia creativa." Universidad Peruana de Ciencias Aplicadas (UPC), 2021. http://hdl.handle.net/10757/657674.
Full textEngdahl, Erica. "The foulest creatures that walk this earth : J.K. Rowling's Magical Creatures as Metaphors for Difficulties for Teenagers." Thesis, Växjö University, School of Humanities, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:vxu:diva-2553.
Full textIn this essay I discuss the magical creatures in the Harry Potter series; not the complete series but Harry Potter and the Chamber of Secrets, Harry Potter and the Prisoner of Azkaban and Harry Potter and the Goblet of Fire. Many scholars say that the Harry Potter novels are didactic, moralist books in different ways. What I investigate is if the magical creatures in the novels can be read as metaphors for issues that the teenage reader finds difficult to deal with and if they could also offer ways to help. More specifically I look at the giant and the werewolf as metaphors for separate types of outsiders who have to try to handle the prejudice of others; one being strange because of genes and one because of an illness. I also look at the house-elf as a metaphor for various oppressive situations one can encounter as a child and also for how to cope with change. In connection to the house-elves I also discuss racism and social class. The last two creatures I investigate are the Dementor as a metaphor for depression and the Boggart as a symbol for fear. My conclusion is that one can read these creatures as symbols or metaphors for difficulties for teenagers in various ways and that these interpretations almost always also offer a way to handle said difficulty.
Stigenberg, Julia. "Hidden Creatures – systematics of the Euphorinae (Hymenoptera)." Doctoral thesis, Stockholms universitet, Zoologiska institutionen, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-87904.
Full textAt the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 3: In press. Paper 4: Manuscript.