Relevant bibliographies by topics / Crispa

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Crispa'

Author: Grafiati
Published: 4 June 2021
Last updated: 14 February 2022

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Journal articles on the topic "Crispa"

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Burri, Josef, and Bernhard Uehleke. "Tinospora crispa – Booraphed." Zeitschrift für Phytotherapie 40, no. 04 (2019): 170–71. http://dx.doi.org/10.1055/a-0986-8596.

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Maroyi, Alfred. "EUCLEA CRISPA: REVIEW OF ITS BOTANY, ETHNOMEDICINAL USES, AND PHARMACOLOGICAL PROPERTIES." Asian Journal of Pharmaceutical and Clinical Research 11, no. 10 (2018): 5. http://dx.doi.org/10.22159/ajpcr.2018.v11i10.25146.

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Euclea crispa is widely used as herbal medicine in southern Africa. This study was aimed at reviewing the botany, ethnomedicinal uses, and validated pharmacological properties of E. crispa. The literature search for information on ethnomedicinal uses and pharmacological activities of E. crispa was undertaken using databases such as web of science, BMC, science direct, elsevier, scopus, PubMed, and scielo. Other relevant literature sources included books, book chapters, websites, theses, conference papers, and other scientific publications. The extensive literature survey revealed that the bark, fruits, leaves, and roots of E. crispa are commonly used as herbal medicines for wounds, constipation, cough, stomach disorders, epilepsy, rheumatism, and diabetes. Pharmacological studies on E. crispa indicate that the species has amyloid β-peptide lowering effects, antibacterial, antidiarrheal, antifungal, and cell membrane disruption activities. E. crispa should be subjected to further scientific evaluations aimed at elucidating its chemical, pharmacological, and toxicological properties. Such detailed research should also include experimental animal studies, randomized clinical trials, and target-organ toxicity studies involving E. crispa extracts and its derivatives.
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Ceñal, Juan P., Oscar S. Giordano, Pedro C. Rossomando, and Carlos E. Tonn. "Neoclerodane Diterpenes fromBaccharis crispa." Journal of Natural Products 60, no. 5 (1997): 490–92. http://dx.doi.org/10.1021/np970003y.

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Nguyen, Tuan Pham, Lam Hong Bang, Tran Thi Bao Nguyen, and Tu Pham Nguyen. "BIOACTIVE COMPOUNDS ANALYSIS AND ANTIOXIDANT ACTIVITIES OF Tinospora crispa MIERS STEM EXTRACT." Scientific Journal of Tra Vinh University 1, no. 40 (2020): 58–69. http://dx.doi.org/10.35382/18594816.1.40.2020.617.

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The study was conducted to analyze some of the bioactive compounds and the antioxidant capacity of Tinospora crispa stem extract. Tinospora crispa stem extract is a prerequisite for the production of products capable of supporting and treating diseases. Tinospora crispa stem extract is made by immersion method withsolvents (water, ethanol 80o and methanol) and combined with ultrasound. Antioxidant activities were tested using DPPHmethods and phenolic, flavonoid, polysaccharide, tannin content were determined by the spectrophotometer method. The results showed that the moisture content was 61.09% and high extraction efficiency of Tinospora crispa stem were between 3.69% and 6.95% respectively. The extract of Tinospora crispa stem contains the presence of biological compounds such as alkaloids, flavonoids, saponin, steroids, tannins and phenols. The phenolic, flavonoid, polysaccharide and tannin content of Tinospora crispa stem were318.91 mg gallic acid/g dry; 36.71 mg quercetin/g dry; 10.38 mg GE/g dry and 38.42 mg tannic acid/g dry respectively. Tinospora crispa stem has antioxidant ability by DPPH method with IC50 value of water, ethanol 80o and methanol 113.69 mg/mg; 89.12 mg/mg; 62.19 mg/mg, respectively. Thus, the Tinospora crispastem extract had bioactive compounds and antioxidant activities, is a potential source of raw materials for research and applications.
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Farris, Emmanuele, Martino Orrù, Mariano Ucchesu, Arianna Amadori, Marco Porceddu, and Gianluigi Bacchetta. "Morpho-Colorimetric Characterization of the Sardinian Endemic Taxa of the Genus Anchusa L. by Seed Image Analysis." Plants 9, no. 10 (2020): 1321. http://dx.doi.org/10.3390/plants9101321.

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In this work, the seed morpho-colorimetric differentiation of the Sardinian endemic species of Anchusa (Boraginaceae) was evaluated. In Sardinia, the Anchusa genus includes the following seven taxa: A. capellii, A. crispa ssp. crispa, A. crispa ssp. maritima, A. formosa, A. littorea, A. montelinasana, and A. sardoa. Seed images were acquired using a flatbed scanner and analyzed using the free software package ImageJ. A total of 74 seed morpho-colorimetric features of 2692 seed lots of seven taxa of Anchusa belonging to 17 populations were extrapolated and used to build a database of seed size, shape, and color features. The data were statistically elaborated by the stepwise linear discriminant analysis (LDA) to compare and discriminate each accession and taxon. In addition, the seed morpho-colorimetric differences among coastal and mountainous taxa were evaluated. Considering the ecological conditions, the LDA was able to discriminate among the Anchusa taxa with a correct identification of 87.4% and 90.8% of specimens for mountainous and coastal plants, respectively. Moreover, the LDA of the 17 populations of Anchusa showed a low separation among species and populations within the coastal group, highlighting how the long-distance dispersal by flotation on the sea water surface and the pollination network may influence the similarity patterns observed. In addition, a misattribution was observed for A. crispa ssp. crispa, which was misclassified as A. crispa ssp. maritima in 14.1% of cases, while A. crispa ssp. maritima was misidentified as A. crispa ssp. crispa in 21.1% of cases, highlighting a close phenotypic relationship between these two taxa. The statistical results obtained through the seed image analysis showed that the morpho-colorimetric features of the seeds provide important information about the adaptation and evolution of Anchusa taxa in Sardinia.
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Albrahim, Tarfa, Moonerah M. Alnasser, Mashael R. Al-Anazi, Muneera D. ALKahtani, Saad Alkahtani, and Ahmed A. Al-Qahtani. "In Vitro Studies on the Immunomodulatory Effects of Pulicaria crispa Extract on Human THP-1 Monocytes." Oxidative Medicine and Cellular Longevity 2020 (September 26, 2020): 1–14. http://dx.doi.org/10.1155/2020/7574606.

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Background. Pulicaria crispa (P. crispa) is a plant from the Compositae family that exhibits antioxidant, anti-inflammatory, antibacterial, and cytotoxic activities. Objective. The current study aimed at investigating the immunomodulatory effects of P. crispa extract in lipopolysaccharide- (LPS-) stimulated human monocytic THP-1 cells. Methods. To induce macrophage differentiation, THP-1 cell lines were treated with phorbol-12-myristate 13-acetate, followed by exposure to LPS with or without 50 or 100 μg/ml of P. crispa extract. The following tests were employed to test the immunomodulatory effects of the extract: MTT assay, ELISA, Western blotting analysis, cell migration and phagocytosis assays, and Annexin V staining method. Results. Exposure to 100 μg/ml P. crispa extract significantly reduced THP-1 cell proliferation, migration, and phagocytosis (in LPS-stimulated cells, but not in unstimulated cells). Moreover, the extract alone significantly reduced the rate of THP-1 cell apoptosis, while it increased the rate of late apoptosis. Molecular investigations showed that treatment with P. crispa extract significantly upregulated the expression of ERK1, p-MAPK, P-P38, and Bcl2, while it significantly reduced the expression of ERK5, Bax, NF-κB, P-NF-κB, CCL1, CCL2, CCL5, CCL22, CXCL1, and CXCL10. Conclusion. Pulicaria crispa extract exhibited anti-inflammatory, antiproliferative, antimigratory, and antiphagocytic effects in LPS-stimulated THP-1 cells. Future studies should investigate these mechanisms in animal models with chronic inflammatory diseases.
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Pretorius, J. C., S. Magama, and P. C. Zietsman. "Purification and identification of antibacterial compounds from Euclea crispa subsp. crispa (Ebenaceae) leaves." South African Journal of Botany 69, no. 4 (2003): 579–86. http://dx.doi.org/10.1016/s0254-6299(15)30298-2.

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Magama, S., J. C. Pretorius, P. C. Zietsman, and B. E. van Wyk. "Antimicrobial properties of extracts from Euclea crispa subsp. crispa (Ebenaceae) towards human pathogens." South African Journal of Botany 69, no. 2 (2003): 193–98. http://dx.doi.org/10.1016/s0254-6299(15)30345-8.

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Sainsbury, Frank, Alexander D. Tattersall, Michael J. Ambrose, Lynda Turner, T. H. Noel Ellis, and Julie M. I. Hofer. "A crispa null mutant facilitates identification of a crispa-like pseudogene in pea." Functional Plant Biology 33, no. 8 (2006): 757. http://dx.doi.org/10.1071/fp06090.

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The genomes of several legume species contain two Phantastica-like genes. Previous studies on leaf development have found that Phantastica confers leaf blade adaxial identity in plant species with simple leaves and leaflet adaxial identity in pea (Pisum sativum L.), a legume with compound leaves. Previous characterisation of the phantastica mutant of pea, crispa, showed it had radialised leaflets, but stipules were not radialised. This suggested either that mutation of a second redundant gene was required for radialisation of stipules, or, that a null mutation was required. Previously characterised crispa mutants may not have exhibited radialised stipules because they were weak alleles. In this work we show that pea has a second Phantastica-like gene, which lies on a different chromosome to Crispa. The second gene was found to be a pseudogene in several genotypes of pea, therefore it would not have a role in conferring stipule adaxial identity. A new deletion mutant, crispa-4 was identified. The mutant has radialised stipules and leaflets, showing that Crispa confers adaxial identity on both these organs in pea. The nucleotide sequence data reported here are in the EMBL and GenBank Nucleotide Databases under the accession numbers DQ486060 (JI 2822), DQ486061 (JI 15), DQ486062 (JI 281) and DQ486063 (JI 399).
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Zhang, Xin, Gao Chen, Weichang Gong, and Weibang Sun. "Buddleja caryopteridifolia (Scrophulariaceae), a species to be recognized based on morphology, floral scent and AFLP data." Phytotaxa 161, no. 3 (2014): 181. http://dx.doi.org/10.11646/phytotaxa.161.3.1.

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Buddleja caryopteridifolia was treated as a synonym of B. crispa in Flora of China. However, it was found that the two entities had different phenologies as well as morphology in the sympatric habitat investigated. Buddleja crispa flowers from mid-March to mid-May while B. caryopteridifolia blooms from early June to mid-September. In this study, the comprehensive comparative analyses of morphological traits, floral scent composition and amplified fragment length polymorphism (AFLP) data were utilized to determine whether B. caryopteridifolia should be recognized as a separate species. Among 13 morphological characters, all but calyx length were significantly different (all p<0.05, t-test) between the two species. Both cluster analysis and principal coordinates analysis (PCoA) of AFLP markers produced two distinct clusters for B. crispa and B. caryopteridifolia. The results of floral scent indicated several differences between B. crispa and B. caryopteridifolia. The main volatile compound of B. crispa was Benzaldehyde, while that of B. caryopteridifolia mostly consisted of trans-β-Ocimene. Therefore, all analyses supported the rehabilitation of B. caryopteridifolia as an independent species.
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Dissertations / Theses on the topic "Crispa"

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Noor, Hamdan H. M. "The hypoglycaemic and insulinotropic activity of Tinospora crispa extract." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236190.

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Santiago, Dimech Gustavo. "Avaliação toxicológica pré-clínica do extrato bruto da Mentha crispa." Universidade Federal de Pernambuco, 2003. https://repositorio.ufpe.br/handle/123456789/2164.

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Made available in DSpace on 2014-06-12T15:55:08Z (GMT). No. of bitstreams: 2 arquivo6208_1.pdf: 2490581 bytes, checksum: 6989208390577460190d50e96c0af7d2 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2003<br>Neste trabalho procuramos avaliar a segurança no uso do extrato bruto (EB) da Mentha crispa, único ingrediente ativo do Giamebil Plus®. Para tal, foram realizados estudos de toxicologia pré-clínica. O EB administrado em camundongos e ratos por via oral (0,1 a 2,0g/kg) não produziu alterações comportamentais em ambas as espécies, contudo, por via i.p. mostrou-se tóxico provocando a morte em camundongos e ratos respectivamente de 100 e 80% dos animais após 48h de observação. Em ratos, os valores estimados da DL50 (g/kg) de 24 horas por via i.p. foram 1,04 (0,98-1,09) e 0,63 (0,57-0,70) respectivamente para machos e fêmeas. Por via oral, não foi possível estimar a DL50, pois não observamos mortes, até 4,0g/kg. Nos estudos de fertilidade em ratos de ambos os sexos, o tratamento com EB (0,5 e 1,0g/kg, v.o.), durante 30 dias antes do acasalamento não induziu alterações nos parâmetros: relação prole/mãe; índices de fertilidade (relação de ratas prenhas por acasaladas); gestação (percentagem de fêmeas prenhas com fetos vivos); viabilidade (percentagem de sobrevida após quatro dias); lactação (percentagem de sobrevida após 28 dias) e o peso dos filhotes no 1o e 28o dia e proporção macho e fêmea. Da mesma forma, pela avaliação dos mesmos parâmetros anteriores, o tratamento, durante o período de gestação (cerca de 22 dias), não produziu alterações no desenvolvimento embrionário como também no período pós-natal. Em outro Protocolo, o tratamento com EB (0,5g/kg, v.o.) nas fases de fecundação (1o ao 7o dia), embriogênica (8o ao 14o dia) e fetal (15o ao 21o dia) não modificou o número de implantes e reabsorvições em relação ao grupo controle. Não foram observadas alterações nos pesos úmidos e na morfologia macroscópica do coração, fígado, baço, rim, cérebro, pulmão, glândula adrenal, ducto deferente, testículo, ovário e útero, após a administração prolongada por 30 dias com EB (1,0g/kg, v.o). Como também não ocorreram alterações na análise da microscópia e morfometria do coração, rim, córtex cerebral e genitálias acessórias. Os parâmetros bioquímicos e hematológicos após tratamento com EB (1,0g/kg, v.o.) por 30 dias, não foram alterados. O conjunto dos resultados permite concluir que o EB da Mentha crispa apresenta baixa toxicidade por via oral e não produz efeitos tóxicos sobre a reprodução em ratos
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Pereira, Charlane Kelly Souto. "Estudo da ação psicofarmacológica de Herissantia crispa (L.) Brizicky (Malvaceae)." Universidade Federal da Paraí­ba, 2009. http://tede.biblioteca.ufpb.br:8080/handle/tede/6761.

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Made available in DSpace on 2015-05-14T12:59:45Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 884408 bytes, checksum: 448afd42d1cb8f67ef7beee9503e0735 (MD5) Previous issue date: 2009-11-11<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Herissantia crispa (L.) Brizicky popularly know as malvaísco is a plant which belongs to the Malvaceae family. There aren t many reports about H. crispa, however, steroids, flavonoids and glycosidic flavonoids with pharmacological activity have been isolated from this species. Other species of Malvaceae have been used in traditional medicine and many studies have shown activities such as anti-inflammatory, antinociceptive, diuretic and others. The aim of this work was to evaluate a possible psychopharmacological activity of H. crispa ethanolic crude extract (EEHc) performing a central nervous system (CNS) investigation in mice. Initially, behavioral pharmacological screening was performed to assess the possible effect of EEHc on the nervous system. Some behavioral changes were observed similar to that of CNS depressant drugs in treated mice. No death was observed 72 hours after treatment with EEHc, nor toxic signs on the highest dose (2000 mg/Kg, i.p.). Therefore we established the doses 500 or 800 mg/kg to perform the pharmacological tests. None of the two doses reduced the time of permanence of mice on a rota-rod revolving bar. On the open-field test, both doses of EEHc significantly reduced ambulation, rearing and defecation, suggesting a profile that resembles hypnotic-sedative drugs. The EEHc treatment did not affect grooming. There were no differences between the control group and the EEHc treated groups when mice were tested for differences in anxiety-related behavior on the elevated plus maze or electroshock- induced tonic convulsions triggered by auricular shock, suggesting that EEHc does not have anxiolytic or anticonvulsant effects. Both doses of EEHc significantly increased the duration of sleeping time induced by sodium thiopental but failed to increase the latency of thiopental-induced hypnosis. Regarding the antinociceptive tests, EEHc significantly reduced acetic acid-induced abdominal writhes in a non dose-dependent manner. EEHc at 500 mg/kg also significantly reduced the hot-plate latency time only 60 minutes after treatment. In the formalin test, EEHc at 500 mg/kg was only able to reduce licking paw time in the first phase of the test. EEHc at the dose of 800 mg/kg reduced licking paw time the first and second phases. These results support the evidence of a central antinociceptive action. In order to confirm the central antinociceptive activity of EEHc, mice were treated with naloxona, an opioid antagonist, and them submitted to formalin test. Since the effect of the EEHc was not reverted by naloxone is excluded the participation of the opioid system in the mechanism of this activity. Therefore, an results suggest that EEHc presented evidences a sedativehypnotic drug profile with central non-opioid antinociceptive activity.<br>A espécie Herissantia crispa (L.) Brizicky, popularmente conhecida como malvaísco, é uma planta pertencente à família Malvaceae. Não há muitos relatos sobre H. crispa na literatura, no entanto, esteróides, flavonóides e glicosídeos flavonoídicos com atividades comprovadas foram isolados desta planta. Outras espécies da família Malvaceae são usadas na medicina tradicional e estudos comprovaram atividades anti-inflamatórias, antinociceptivas, diuréticas, entre outras. O objetivo do presente trabalho foi avaliar as possíveis ações psicofarmacológicas do extrato etanólico de Herissantia crispa (EEHc), pela investigação de seus efeitos no sistema nervoso central (SNC), em camundongos. Inicialmente, foi realizada a triagem farmacológica comportamental, para verificar o possível efeito do EEHc no sistema nervoso. Algumas alterações comportamentais semelhantes às de drogas depressoras do SNC foram observadas nos camundongos tratados, tais como, redução da ambulação e pequeno grau de ptose. Nas 72 horas seguintes não houve morte dos animais, nem presença de sinais tóxicos na maior dose possível (2000 mg/kg i.p), sendo estabelecidas as doses de 500 e 800 mg/kg para os testes subsequentes. Nenhuma das doses testadas do EEHc diminuíram o tempo de permanência dos animais na barra giratória no teste do rota-rod. No teste do campo aberto, as duas doses testadas do EEHc diminuíram significativamente a ambulação, o comportamento de levantar e a defecação, sugerindo perfil semelhante ao de drogas sedativo-hipnóticas. O comportamento de autolimpeza não foi alterado por nenhuma dose. O tratamento dos animais com o EEHc nas doses testadas não alteraram seu comportamento no teste do labirinto em cruz elevado e também não protegeram os animais contra as convulsões induzidas pelo eletrochoque auricular, descartando-se os efeitos ansiolítico e anticonvulsivante, respectivamente. As doses de 500 e 800 mg/kg do EEHc induziram significante potencialização do tempo do sono induzido pelo tiopental, no entanto, não alteraram a latência de indução do sono, característica semelhante à de drogas sedativa-hipnóticas. Na avaliação da atividade antinociceptiva, o EEHC reduziu significativamente o número de contorções abdominais, evidenciando atividade antinociceptiva. Tal efeito não foi dose dependente, pois foi mais pronunciado na dose de 500mg/kg do que na dose de 800mg/kg. No teste da placa quente o EEHc aumentou o tempo de latência ao estímulo térmico apenas na dose de 500 mg/kg, 60 minutos após o tratamento. No teste da formalina, o EEHc na dose de 500 mk/kg só foi capaz de reduzir o tempo de lambida na primeira fase do teste, mas a dose de 800 mg/kg reduziu o tempo de lambida da pata na primeira e segunda fase do teste , confirmando assim o efeito antinociceptivo de ação central. Para detalhar essa atividade antinociceptiva, realizou-se o teste da formalina submetendo os animais a um tratamento prévio com a naloxona, um antagonista opióide, no entanto, o efeito antinociceptivo não foi revertido, excluindo assim a participação do sistema opióide no mecanismo desta atividade. Portanto, baseado nos resultados obtidos no presente estudo, o EEHC apresentou características de drogas com perfil sedativo-hipnótico e atividade antinociceptiva central, sem participação do sistema opióide.
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Kimura, Takashi. "Studies on pharmacological activities of the cauliflower mushroom Sparassis crispa." Kyoto University, 2013. http://hdl.handle.net/2433/180630.

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Tattersall, Alexander. "The role of CRISPA in pea compound leaf initiation and elaboration." Thesis, University of East Anglia, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399816.

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Teles, NaracÃlia Sousa Barbosa. "AvaliaÃÃo da eficÃcia terapÃutica da Mentha crispa no tratamento da giardÃase." Universidade Federal do CearÃ, 2008. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=2443.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>Giardia lamblia infection is endemic in lots of parts of the world. It is estimated that around 200 million of people are parasitized every year, being the disease an important reason for morbidity in the entire world. Current treatment for Giardia infection in humans involves the use of lots of medication. Phitotherapics formulated with Mentha crispa has been used also as giardicides, however its efficacy was not yet established. Hence, the aim of the present study was to evaluate the therapeutic efficacy of Mentha crispa in giardiasis. Initially the research constituted a transversal study for selection of subjects with giardiasis, as well as for determination of prevalence of the main intestinal parasitosis. Afterwards it was realized a double-blind, randomized clinical trial with active control to verify the therapeutic efficacy of Mentha crispa in giardiasis. Coprological samples of 1622 patients from both sexes and 5-year old minimum age were collected for the period May, 2005 to May, 2007 for serial coproscopy examination. It was selected 96 patients with Giardia lamblia who were randomly distributed into two groups: Secnidazol, constituted by 50 patients, who were treated with 2 g of secnidazol (SecnidalÂ); and Mentha crispa, constituted by 46 subjects treated with 24 mg of Mentha crispa (GiamebilÂ). Treatments were administrated in a single dose orally. After 7 days, cure was evaluated by immunoenzymatic assay (ELISA) in a freshly fecal sample. In addition, subjects were asked for possible side effects, and they answered a questionnaire about hidrosanitary and socioeconomics aspects. Transversal study results showed 47.78% of prevalence of enteroparasitosis in general. More prevalent protozoa were: Endolimax nana (20.47%), Entamoeba coli (18.56%), Giardia lamblia (7.83%), and Entamoeba histolytica (2.22%). Among helminthes, the most prevalent were: Ascaris lumbricoides (10.36%) and Trichocephalus trichiurus (2.59%). During the analysis of the clinical trial, it was found that the cure rate observed in the Secnidazol group (84.00%) was significantly higher (P = 0.0002) than that observed in Mentha crispa group (47.83%). The medications were well tolerated once it was observed only three low intensity adverse events. It was verified that the occurrence of abdominal pain was significantly higher in Mentha crispa group. However, the report of metallic taste was significantly higher in Secnidazol group. On the other side, the occurrence of nausea did not differ significantly between the groups. The data from socioeconomic questionnaire corroborated the relation between poverty, low schoolarity, absence of sanitation, and the occurrence of Giardia lamblia infection. It follows therefore that, at the dose used, the giardicide effect of Mentha crispa is lower than the secnidazol.<br>A infecÃÃo por Giardia lamblia à endÃmica em vÃrias partes do mundo. Estima-se que em torno de 200 milhÃes de pessoas sÃo parasitadas anualmente, sendo a doenÃa uma importante causa de morbidade em todo o mundo. O tratamento atual da giardÃase compreende o uso de vÃrios fÃrmacos. FitoterÃpicos formulados com Mentha crispa tambÃm tÃm sido empregados como giardicidas, porÃm a sua eficÃcia ainda nÃo foi totalmente estabelecida. Assim, o objetivo do presente estudo foi avaliar a eficÃcia terapÃutica da Mentha crispa na giardÃase. A pesquisa consistiu, inicialmente, de um estudo transversal para seleÃÃo dos sujeitos portadores de giardÃase, bem como para a determinaÃÃo da prevalÃncia das principais parasitoses intestinais. Em seguida, realizou-se um ensaio clÃnico randomizado, duplo-cego, em paralelo, com controle ativo, para verificar a eficÃcia terapÃutica da Mentha crispa na giardÃase. Amostras coprolÃgicas de 1622 pacientes, de ambos os sexos e com idade mÃnima de cinco anos, foram coletadas no perÃodo de maio de 2005 a maio de 2007 para exame coproscÃpico seriado. Selecionaram-se 96 pacientes portadores de Giardia lamblia, os quais foram distribuÃdos de forma aleatÃria em dois grupos: Secnidazol, constituÃdo de 50 pacientes tratados com 2 g de secnidazol (SecnidalÂ); e Mentha crispa, composto por 46 pacientes medicados com 24 mg de Mentha crispa (GiamebilÂ). Os tratamentos foram administrados por via oral e em dose Ãnica. ApÃs 7 dias, avaliou-se a cura atravÃs do ensaio imunoenzimÃtico (Elisa) em uma amostra fecal fresca. Adicionalmente, os sujeitos foram questionados acerca de possÃveis efeitos adversos e responderam a um questionÃrio abordando aspectos socioeconÃmicos e hidrossanitÃrios. Os resultados do estudo transversal mostraram que a prevalÃncia das enteroparasitoses em geral foi de 47,78%. Os protozoÃrios mais prevalentes foram: Endolimax nana (20,47%), Entamoeba coli (18,56%), Giardia lamblia (7,83%) e Entamoeba histolytica (2,22%). Entre os helmintos, os mais prevalentes foram: Ascaris lumbricoides (10,36%) e Trichocephalus trichiurus (2,59%). Um total de 96 pacientes completaram o ensaio clinico, 50 no grupoSecnidazol e 46 no grupo Mentha crispa. Na anÃlise dos dados do ensaio clÃnico, constatou-se que a taxa de cura observada no grupo Secnidazol (84,00%) foi significantemente maior (P = 0,0002) que a verificada no grupo Mentha crispa (47,83%). As medicaÃÃes foram bem toleradas uma vez que foram observados apenas trÃs eventos adversos de intensidade leve. Verificou-se que a ocorrÃncia de dor abdominal foi significantemente maior no grupo Mentha crispa. Todavia, o relato de gosto metÃlico foi significantemente maior no grupo Secnidazol. Por outro lado, a ocorrÃncia de nÃusea nÃo diferiu significantemente entre os grupos. Os dados do questionÃrio socioeconÃmico, por sua vez, corroboraram a Ãntima relaÃÃo entre pobreza, baixa escolaridade e falta de saneamento e a ocorrÃncia de infecÃÃo por Giardia lamblia. Conclui-se, pois, que, na dose empregada, o efeito giardicida da Mentha crispa à inferior ao do secnidazol.
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Carvalho, Evelise Leis. "Genomas acessórios da alga Antártica Prasiola Crispa: inferências estruturais e filogenéticas." Universidade Federal do Pampa, 2015. http://dspace.unipampa.edu.br:8080/xmlui/handle/riu/614.

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Submitted by Ana Damasceno (ana.damasceno@unipampa.edu.br) on 2016-11-07T16:30:36Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Dissertação - Evelise Carvalho.pdf: 2321912 bytes, checksum: 3957e800afc8b54ee2d2bc427c9dffd6 (MD5)<br>Made available in DSpace on 2016-11-07T16:30:36Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Dissertação - Evelise Carvalho.pdf: 2321912 bytes, checksum: 3957e800afc8b54ee2d2bc427c9dffd6 (MD5) Previous issue date: 2015-05-19<br>Algas verdes da classe Trebouxiphyceae estão entre os organismos presentes no continente Antártico, onde a espécie mais relatada é a macroalga verde Prasiola crispa (Lightfoot) Kützing. Considerada um organismo extremófilo, pois se desenvolve com muito sucesso no habitat extremo da Antártica, ainda são raros na literatura dados moleculares sobre esta espécie, o que impede uma avaliação sobre sua taxonomia e posição filogenética. Com o advento das tecnologias de sequenciamento de nova geração, os genomas de organelas tornaram-se uma grande ferramenta para estudos de filogenia, pois fornecem inúmeros dados filogenéticos, sequências de proteínas e nucleotídeos e também informações sobre conteúdo gênico e arquitetura. Neste trabalho, foi determinada a sequência dos genomas do cloroplasto (cpDNA) e mitocondrial (mtDNA) de P. crispa, com o intuito de inferir as relações evolutivas deste organismos com outras espécies de plantas verdes, bem como uma análise estrutural. Os genomas plastidial e mitocondrial foram sequenciados por Macrogen Service (SolexaIllumina Hi-Seq 2500). A montagem, anotação, alinhamento, construção da filogenia e análise sintênica foram realizados in silico com softwares específicos. O cpDNA e mtDNA P. crispa apresentam 196.502 pb e 89.819 pb, respectivamente. Estes genomas acessórios apresentam 21 genes putativos relacionados com a fotossíntese e 18 genes relacionados com o metabolismo oxidativo. A análise filogenômica baseada no cpDNA demonstrou que P. crispa agrupou com alga trebouxiophyceae Prasiolopsis sp. formando o clado Prasiola juntamente com Stichococcus bacilaris. Nossos resultados para filogenômica embasada no mtDNA revelam que P. crispa agrupa com as outras espécies da classe Trebouxiphyceae. A análise de sintenia do cpDNA e mtDNA de P. crispa com a espécies de plantas verdes relacionadas evolutivamente demonstram que estes organismos apresentam poucos blocos gênicos sintênicos. Este trabalho pioneiro com a alga P. crispa, demonstra que os genomas acessórios suprem uma gama de dados moleculares que podem ser utilizados para estudos filogenômicos. Além disto, as informações geradas a partir do sequenciamento do cpDNA e mtDNA de P. crispa fornecem um aporte para estudos futuros mais aprofundados<br>Green algae from Trebouxiophyceae class are among the organisms in the Antarctic continent, where the most reported species is the green macroalga Prasiola crispa (Lightfoot) Kützing. This algae is considered an extremophile organism because develops successfully in the harsh Antarctic habitat, however studies reporting molecular data of this species are still lacking in the literature, which prevents an assessment of their correct taxonomy and phylogenetic position. With the advent of next generation sequencing technologies, it because easier to obtain molecular information as for example from organelle genomes making them a great tool for taxonomic studies because they provide a great number of, phylogenetic data, nucleotides, protein sequences, gene content and architecture information. In this study, we determined the sequence of the chloroplast (cpDNA) and mitochondrial (mtDNA) genome of P. crispa in order to infer the evolutionary relationships of the organisms with other species of green plants, as well as a structural analysis. Plastid and mitochondrial genome was sequenced by Macrogen Service (Illumina Solexa Hi-Seq 2500). The genome assembly, annotation, sequences alignment, phylogeny construction, and structural analyses were performed in silico with specific softwares. Plastid and Mitochondrial genomes have a total length of 196,502 bp and 89,819 bp, respectively. These genomes presented 21 putative photosynthesis related genes and 18 oxidative metabolism related genes, respectively. Phylogenetic analysis based on the cpDNA demonstrated that P. crispa grouped with Trebouxiophyceae algae Prasiolopsis sp. forming the Prasiola clade along with Stichococcus bacilaris. Our results for phylogenetic analysis grounded in mtDNA show that P. crispa groups with other species of Trebouxiphyceaen alga. Synteny analysis of P. crispa cpDNA and mtDNA with evolutionarily related species of green plants shows that these organisms have few syntenic gene blocks. This pioneering work with P. crispa provided the accessories genomes which suppled a range of molecular data that can be employed to taxonomic studies. In addition, the information generated from the sequencing of cpDNA and mtDNA of P. crispa provide a contribution for further studies.
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8

Teles, Naracélia Sousa Barbosa. "Avaliação da eficácia terapêutica da mentha crispa no tratamento da giardíase." reponame:Repositório Institucional da UFC, 2008. http://www.repositorio.ufc.br/handle/riufc/2594.

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TELES, Naracélia Sousa Barbosa. Avaliação da Eficácia terapêutica da mentha crispa no tratamento da giardíase. 2008. 163 f. Dissertação (Mestrado em Farmacologia) - Universidade Federal do Ceará. Faculdade de Medicina, Fortaleza, 2008.<br>Submitted by denise santos (denise.santos@ufc.br) on 2012-05-07T16:26:22Z No. of bitstreams: 1 2008_dis_nsbteles.pdf: 2222125 bytes, checksum: 34ba0d1584c701ada0b561143e7bd790 (MD5)<br>Approved for entry into archive by Eliene Nascimento(elienegvn@hotmail.com) on 2012-05-08T16:54:19Z (GMT) No. of bitstreams: 1 2008_dis_nsbteles.pdf: 2222125 bytes, checksum: 34ba0d1584c701ada0b561143e7bd790 (MD5)<br>Made available in DSpace on 2012-05-08T16:54:19Z (GMT). No. of bitstreams: 1 2008_dis_nsbteles.pdf: 2222125 bytes, checksum: 34ba0d1584c701ada0b561143e7bd790 (MD5) Previous issue date: 2008<br>Giardia lamblia infection is endemic in lots of parts of the world. It is estimated that around 200 million of people are parasitized every year, being the disease an important reason for morbidity in the entire world. Current treatment for Giardia infection in humans involves the use of lots of medication. Phitotherapics formulated with Mentha crispa has been used also as giardicides, however its efficacy was not yet established. Hence, the aim of the present study was to evaluate the therapeutic efficacy of Mentha crispa in giardiasis. Initially the research constituted a transversal study for selection of subjects with giardiasis, as well as for determination of prevalence of the main intestinal parasitosis. Afterwards it was realized a double-blind, randomized clinical trial with active control to verify the therapeutic efficacy of Mentha crispa in giardiasis. Coprological samples of 1622 patients from both sexes and 5-year old minimum age were collected for the period May, 2005 to May, 2007 for serial coproscopy examination. It was selected 96 patients with Giardia lamblia who were randomly distributed into two groups: Secnidazol, constituted by 50 patients, who were treated with 2 g of secnidazol (Secnidal®); and Mentha crispa, constituted by 46 subjects treated with 24 mg of Mentha crispa (Giamebil®). Treatments were administrated in a single dose orally. After 7 days, cure was evaluated by immunoenzymatic assay (ELISA) in a freshly fecal sample. In addition, subjects were asked for possible side effects, and they answered a questionnaire about hidrosanitary and socioeconomics aspects. Transversal study results showed 47.78% of prevalence of enteroparasitosis in general. More prevalent protozoa were: Endolimax nana (20.47%), Entamoeba coli (18.56%), Giardia lamblia (7.83%), and Entamoeba histolytica (2.22%). Among helminthes, the most prevalent were: Ascaris lumbricoides (10.36%) and Trichocephalus trichiurus (2.59%). During the analysis of the clinical trial, it was found that the cure rate observed in the Secnidazol group (84.00%) was significantly higher (P = 0.0002) than that observed in Mentha crispa group (47.83%). The medications were well tolerated once it was observed only three low intensity adverse events. It was verified that the occurrence of abdominal pain was significantly higher in Mentha crispa group. However, the report of metallic taste was significantly higher in Secnidazol group. On the other side, the occurrence of nausea did not differ significantly between the groups. The data from socioeconomic questionnaire corroborated the relation between poverty, low schoolarity, absence of sanitation, and the occurrence of Giardia lamblia infection. It follows therefore that, at the dose used, the giardicide effect of Mentha crispa is lower than the secnidazol.<br>A infecção por Giardia lamblia é endêmica em várias partes do mundo. Estima-se que em torno de 200 milhões de pessoas são parasitadas anualmente, sendo a doença uma importante causa de morbidade em todo o mundo. O tratamento atual da giardíase compreende o uso de vários fármacos. Fitoterápicos formulados com Mentha crispa também têm sido empregados como giardicidas, porém a sua eficácia ainda não foi totalmente estabelecida. Assim, o objetivo do presente estudo foi avaliar a eficácia terapêutica da Mentha crispa na giardíase. A pesquisa consistiu, inicialmente, de um estudo transversal para seleção dos sujeitos portadores de giardíase, bem como para a determinação da prevalência das principais parasitoses intestinais. Em seguida, realizou-se um ensaio clínico randomizado, duplo-cego, em paralelo, com controle ativo, para verificar a eficácia terapêutica da Mentha crispa na giardíase. Amostras coprológicas de 1622 pacientes, de ambos os sexos e com idade mínima de cinco anos, foram coletadas no período de maio de 2005 a maio de 2007 para exame coproscópico seriado. Selecionaram-se 96 pacientes portadores de Giardia lamblia, os quais foram distribuídos de forma aleatória em dois grupos: Secnidazol, constituído de 50 pacientes tratados com 2 g de secnidazol (Secnidal®); e Mentha crispa, composto por 46 pacientes medicados com 24 mg de Mentha crispa (Giamebil®). Os tratamentos foram administrados por via oral e em dose única. Após 7 dias, avaliou-se a cura através do ensaio imunoenzimático (Elisa) em uma amostra fecal fresca. Adicionalmente, os sujeitos foram questionados acerca de possíveis efeitos adversos e responderam a um questionário abordando aspectos socioeconômicos e hidrossanitários. Os resultados do estudo transversal mostraram que a prevalência das enteroparasitoses em geral foi de 47,78%. Os protozoários mais prevalentes foram: Endolimax nana (20,47%), Entamoeba coli (18,56%), Giardia lamblia (7,83%) e Entamoeba histolytica (2,22%). Entre os helmintos, os mais prevalentes foram: Ascaris lumbricoides (10,36%) e Trichocephalus trichiurus (2,59%). Um total de 96 pacientes completaram o ensaio clinico, 50 no grupoSecnidazol e 46 no grupo Mentha crispa. Na análise dos dados do ensaio clínico, constatou-se que a taxa de cura observada no grupo Secnidazol (84,00%) foi significantemente maior (P = 0,0002) que a verificada no grupo Mentha crispa (47,83%). As medicações foram bem toleradas uma vez que foram observados apenas três eventos adversos de intensidade leve. Verificou-se que a ocorrência de dor abdominal foi significantemente maior no grupo Mentha crispa. Todavia, o relato de gosto metálico foi significantemente maior no grupo Secnidazol. Por outro lado, a ocorrência de náusea não diferiu significantemente entre os grupos. Os dados do questionário socioeconômico, por sua vez, corroboraram a íntima relação entre pobreza, baixa escolaridade e falta de saneamento e a ocorrência de infecção por Giardia lamblia. Conclui-se, pois, que, na dose empregada, o efeito giardicida da Mentha crispa é inferior ao do secnidazol.
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9

Cavalcanti, PacÃfica Pinheiro. "Estudo comparativo, randomizado para avaliar a eficÃcia terapÃutica da Mentha crispa e do secnidazol no tratamento da tricomonÃase." Universidade Federal do CearÃ, 2010. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=4054.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>TricomonÃase à a doenÃa sexualmente transmissÃvel nÃo-viral mais comum no mundo. O tratamento atual dessa patologia compreende o uso de vÃrios fÃrmacos, inclusive fitoterÃpicos formulados com Mentha crispa tambÃm tÃm sido empregados como antiprotozoÃrios. O objetivo desse estudo foi avaliar a eficÃcia terapÃutica e a seguranÃa do fitoterÃpico contendo Mentha crispa (GiamebilÂ) em pacientes com tricomonÃase vaginal. O estudo realizado foi um ensaio clÃnico do tipo randomizado, paralelo e aberto com 60 voluntÃrias do sexo feminino, sendo 35 procedentes de Fortaleza/Cearà e 25 da cidade de Sinop/Mato Grosso, que apresentaram exame parasitolÃgico positivo da secreÃÃo vaginal para tricomonÃase. As pacientes foram distribuÃdas aleatoriamente em dois grupos de tratamento, o grupo Mentha crispa e o grupo Secnidazol, ambos compostos de 30 voluntÃrias, os quais foram administrados por via oral, respectivamente, 2 comprimidos de 12 mg de Giamebil e 2 comprimidos de 1000 mg de SecnidalÂ, em dose Ãnica. O ensaio clÃnico foi constituÃdo de trÃs etapas: prÃ-tratamento, tratamento e pÃs-tratamento. Ao nÃvel de significÃncia de 5%, nÃo se constatou diferenÃa estatÃstica entre os grupos (P=0,6120), pois a proporÃÃo de voluntÃrias com ausÃncia de T.vaginalis no grupo Secnidazol foi de 96,67% e a verificada no grupo Mentha crispa foi de 90,00%. Os desfechos secundÃrios para a avaliaÃÃo da eficÃcia da Mentha crispa no tratamento da tricomonÃase foram a melhora das queixas clÃnicas: corrimento vaginal, odor desagradÃvel, ardor genital, disÃria, dispareunia, prurido e dor pÃlvica. NÃo foi demonstrada diferenÃa estatisticamente significante (P=0,4583) entre os tratamentos em relaÃÃo à proporÃÃo de pacientes que relataram ausÃncia dessas queixas. Os medicamentos foram considerados bem tolerados, pois nenhuma voluntÃria necessitou intervenÃÃo farmacolÃgica adicional no intuito de controlar ou debelar tal desconforto. Portanto, os eventos adversos foram avaliados como sendo de intensidade leve, manifestando-se uma Ãnica vez e com remissÃo espontÃnea. Entretanto, os efeitos adversos foram significativamente maiores (P = 0,0006) no grupo Secnidazol (66,67%) do que os verificados no grupo Mentha crispa (20,00%). Os eventos adversos relatados pelas voluntÃrias do grupo Secnidazol foram: nÃusea (16,67%), odor desagradÃvel na urina (3,33%) e gosto metÃlico, sendo que esse citado por 50% das pacientes evidenciou diferenÃa estatisticamente significante entre os grupos de tratamento (P <0,001). Os eventos referidos pelas voluntÃrias do grupo Mentha crispa foram: epigastralgia, nÃusea, vÃmito e cefalÃia referidos por 3,33%, enquanto gosto desagradÃvel foi mencionado por 6,67%. Nenhum sinal de toxicidade clÃnica foi observado no perÃodo de tratamento. O presente ensaio clÃnico concluiu que o fitoterÃpico contendo Mentha crispa apresentou eficÃcia terapÃutica e seguranÃa quando empregado por via oral na dose Ãnica de 24mg, apresentando-se como uma alternativa terapÃutica segura, eficaz, acessÃvel e de qualidade para o tratatamento de pacientes com tricomonÃase.<br>Trichomoniasis is a non-viral sexually transmitted disease most common in the world. The current treatment of this disease includes the use of several drugs, including herbal remedies formulated with Mentha crispa have also been used as protozoan The aim of this study was to evaluate the efficacy and safety of herbal medicine containing Mentha crispa in patients with vaginal trichomoniasis. The study was a randomized clinical trial, parallel and opened. It included 60 female volunteers, 35 from Fortaleza - Ceara and 25 from Sinop - Mato Grosso, who had stool examination of vaginal discharge positive for trichomoniasis. Patients were randomly distributed in two treatment groups, the Mentha crispa group and the Secnidazole group. Both groups were composed of 30 volunteers, in which, respectively, 2 tablets of 12 mg of herbal Giamebil and 2 tablets 1000mg Secnidal  were orally administered in single dose. The clinical trial consisted of three steps: pretreatment, treatment and post-treatment. To significance level of 5%, no difference was found between the groups (P = 0.6120), because the proportion of volunteers with no T.vaginalis in the Secnidazole group was 96.67% and the proportion found in the Mentha crispa group was 90.00%. Secondary endpoints for the evaluation of the effectiveness of Mentha crispa in the treatment of trichomoniasis were the improvement of clinical complaints: vaginal discharge, unpleasant odor, genital burning, dysuria, dyspareunia, pelvic pain and itching. It has not been demonstrated statistically significant difference (P = 0 , 4583) between the treatments in the proportion of patients who reported no such complaints. The drugs were considered well tolerated, as no voluntary needed additional pharmacological intervention in order to control or eradicate such discomfort. Therefore, adverse events were assessed as being mild, manifesting itself only once and having spontaneous remission. However, adverse effects were significantly higher (P = 0.0006) in the Secnidazole group (66.67%) than those found in the Mentha crispa group (20.00%). Adverse events reported by volunteers Secnidazole group were nausea (16.67%), the unpleasant odor in the urine (3.33%) and metallic taste, that was cited by 50% of patients and it showed a statistically significant difference between the treatment groups (P <0.001). The referred events by the volunteers of the Mentha crispa group were: epigastric pain, nausea, vomiting and headache reported by 3.33%, while unpleasant taste was mentioned by 6.67%. No signs of clinical toxicity was observed during treatment. This trial concluded that the herbal medicine containing Mentha crispa showed efficacy and safety when used orally at a dose of 24mg, presenting itself as an alternative therapy safe, effective, accessible and with quality for treatment in patients with trichomoniasis.
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Pereira, Charlane Kelly Souto. "Atividade antinociceptiva e anti-inflamatória de Herissantia crispa (L.) Brizicky em camundongos." Universidade Federal da Paraí­ba, 2013. http://tede.biblioteca.ufpb.br:8080/handle/tede/6820.

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Made available in DSpace on 2015-05-14T13:00:02Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 1186433 bytes, checksum: a2657e7816d226f92f3431c0227b0dbc (MD5) Previous issue date: 2013-09-09<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>The Herissantia crispa (L.) Brizicky (Malvaceae), is composed of substances that have proven activities, such as anti-inflammatory, antinociceptive and antioxidant. There are few reports in the literature of this plant, but previous studies have determined, that H.crispa characteristics of drugs with antinociceptive and sedative-hypnotic profile. The aim of this study was to evaluate the antinociceptive effect of H. crispa, using the ethyl acetate phase from H. crispa (FAEHc), hydroalcoholic phase (FHAHc) and two flavonoids isolated from this plant (tiliroside and lespedin), as well as the possible mechanisms involved in this activity and the anti-inflammatory effect. To determine the antinociceptive mechanisms of action and the anti-inflammatory activity only FAEHc was used. The experiments conducted in mice demonstrate that FAEHc, FHAHc and flavonóides, injected via i.p., promoted significantly antinociception in the formalin test, and also showed a significantly reduction in the glutamate-induced nociception. The antinociception produced by FAEHc was significantly reversed by pretreatment of animals with caffeine, atropine or L-arginine suggesting involvement of adenosinergic, muscarinic and oxidonitrergic systems, respectively. However, FAEHc antinociceptive response was not blocked when animals were pretreated with naloxone, yohimbine and glibenclamide, indicating that FAEHc probably is not acting through these pathways. The treatment of animals with FAEHc promoted significant reduction of the paw edema induced by carrageenan in the first 48 hours of the test. Furthermore, FAEHc significantly decreased leukocyte migration, particularly the influx of neutrophils, and the levels of TNF-α and IL-1β in the model of peritonitis induced by carrageenan. Considering the results obtained in this study, is evident that FAEHc, FHAHc and flavonoids lespedin and tiliroside, chemical markers of this plant, have antinociceptive activity, but this effect cannot be attributed only to the markers, since the effect was lower than that shown by the phases and the crude extract. Also, the antinociception induced by FAEHc possibly involves activation of adenosine and muscarinic receptors as well as the nitric oxide pathway. Furthermore, FAEHc is capable of promoting a reduction of inflammation, and this effect is related to the reduction of leukocyte influx to the site of inflammation that could be attributed to inhibiting of the production of TNF-α and IL-1β<br>A Herissantia crispa (L.) Brizicky (Malvaceae), é composta por substâncias que apresentam atividades anti-inflamatória, antinociceptiva e antioxidante comprovadas. Há poucos relatos desta planta na literatura, mas já foi determinado, em estudos anteriores, que H. crispa apresenta características de fármacos com perfil sedativo-hipnótico e antinociceptivo. O objetivo do presente trabalho foi avaliar o efeito antinociceptivo da H. crispa, utilizando a fase acetato de etila da H. crispa (FAEHc), a fase hidroalcoólica (FHAHc) e dois flavonóides isolados desta planta (tilirosídeo e lespedina), assim como, os possíveis mecanismos de ação envolvidos nesta atividade, além do efeito anti-inflamatório. Para a determinação dos mecanismos de ação antinociceptivos e da atividade anti-inflamatória usou-se apenas a FAEHc. Os experimentos realizados em camundongos demonstram que a FAEHc, a FHAHc e os flavonóides administrados por via i.p., promoveram antinocicepção significativa no teste da formalina, porém, este efeito foi mais pronunciado com a FAEHc, que também mostrou significativa redução na nocicepção induzida pelo glutamato. A antinocicepção produzida pela FAEHc foi significativamente revertida pelo pré-tratamento dos animais com cafeína, atropina e L-arginina sugerindo envolvimento dos sistemas adenosinérgico, muscarínico e oxidonitrérgico, respectivamente. Contudo, a resposta antinociceptiva da FAEHc não foi bloqueada quando os animais foram pré-tratados com naloxona, ioimbina e glibenclamida, indicando que a FAEHc provavelmente não atua por essas vias. O tratamento dos animais com a FAEHc promoveu significante redução do edema de pata induzido pela carragenina nas primeiras 48 horas do teste. Além disso, a FAEHc diminuiu significativamente a migração leucocitária, particularmente o influxo de neutrófilos, e os níveis das citocinas TNF-α e IL-1β no modelo da peritonite induzida por carragenina. Considerando os resultados obtidos no presente trabalho, fica evidente que a FAEHc, a FHAHc e os flavonóides lespedina e tilirosídeo, marcadores químicos desta planta, apresentam atividade antinociceptiva, porém não se pode atribuir tal efeito exclusivamente aos marcadores, uma vez que o efeito apresentado foi inferior ao apresentado pelas fases e extrato bruto. E a antinocicepção induzida pela FAEHc possivelmente envolve ativação de receptores adenosinérgicos, de receptores muscarínicos e a via que envolve o óxido nítrico. Além disso, a FAEHc é capaz de promover controle da inflamação, e esse efeito está relacionado com a redução do influxo de leucócitos para o local da inflamação que pode ser atribuída a inibição da produção das citocinas TNF-α e IL-1β
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Books on the topic "Crispa"

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Jacob, Andreas. Physiologie und Ultrastruktur der antarktischen Grünalge Prasiola crispa ssp. antarctica unter osmotischem Stress und Austrocknung =: Physiology and ultrastructure of the Antarctic green alga Prasiola crispa ssp. antarctica subjected to osmotic stress and desiccation. Alfred-Wegener-Institut für Polar-und Meeresforschung, 1992.

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Jacob, Andreas. Physiologie und Ultrastruktur der antarktischen Grünalge Prasiola crispa ssp. antarctica unter osmotischem Stress und Austrocknung =: Physiology and ultrastructure of the Antarctic green alga Prasiola crispa ssp. antarctica subjected to osmotic stress and desiccation. Alfred-Wegener-Institut für Polar- und Meeresforschung, 1992.

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Robb, Lindsay. The potential for the use of green alder (Alnus viridis ssp. crispa (Ait.) turrill) in the revegetation of the Sudbury, Ontario Barrens. Laurentian University, Department of Biology, 2001.

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Adnan, Adek Zambrud. Pemeriksaan efek antimalaria tinokrisposid, senyawa furanoditerpen glikosida baru dari Tinospora crispa Miers (Brotowali): Tahun I, percobaan secara in vitro, th. II, percobaan secara in vivo : laporan penelitian. Departemen Pendidikan dan Kebudayaan, Lembaga Penelitian, Universitas Andalas, 1997.

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Crippa, Roberto. Crippa. Galleria Il castello, 2000.

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Romano, Sergio. Crispi. Bompiani, 1986.

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Lundgren, Magnus, Emmanuelle Charpentier, and Peter C. Fineran, eds. CRISPR. Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2687-9.

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Crisp. NeWest, 2010.

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Roberto, Crippa. Roberto Crippa. Mazzotta, 1999.

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Francesco Crispi. Flaccovio, 2012.

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Book chapters on the topic "Crispa"

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Azimova, Shakhnoza S., and Anna I. Glushenkova. "Malva crispa L." In Lipids, Lipophilic Components and Essential Oils from Plant Sources. Springer London, 2012. http://dx.doi.org/10.1007/978-0-85729-323-7_2048.

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Lim, T. K. "Ribes uva-crispa." In Edible Medicinal And Non-Medicinal Plants. Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-94-007-4053-2_6.

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Khare, C. P. "Leea crispa Linn." In Indian Medicinal Plants. Springer New York, 2007. http://dx.doi.org/10.1007/978-0-387-70638-2_894.

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Azimova, Shakhnoza S., and Anna I. Glushenkova. "Monardella crispa Elmer." In Lipids, Lipophilic Components and Essential Oils from Plant Sources. Springer London, 2012. http://dx.doi.org/10.1007/978-0-85729-323-7_1388.

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Welander, M. "Gooseberry [Ribes uva-crispa (grossularia)]." In Crops II. Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73520-2_6.

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Dapar, Mark Lloyd Granaderos. "Tinospora crispa (L.) Hook.f. & Thomson Menispermaceae." In Ethnobotany of Mountain Regions. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-14116-5_97-1.

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Dapar, Mark Lloyd Granaderos. "Tinospora crispa (L.) Hook.f. & Thomson Menispermaceae." In Ethnobotany of Mountain Regions. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-38389-3_97.

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Khare, C. P. "Tinospora crispa Linn. Miers ex Hook. f. Thoms." In Indian Medicinal Plants. Springer New York, 2007. http://dx.doi.org/10.1007/978-0-387-70638-2_1640.

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Batsatsashvili, Ketevan, Naiba Mehdiyeva, George Fayvush, et al. "Ribes alpinum L. Ribes orientale Desf. Ribes petraeum Wulfen Ribes uva-crispa L. Grossulariaceae." In European Ethnobotany. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-50009-6_59-1.

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Batsatsashvili, Ketevan, Naiba P. Mehdiyeva, George Fayvush, et al. "Ribes alpinum L. Ribes orientale Desf. Ribes petraeum Wulfen Ribes uva-crispa L. Grossulariaceae." In European Ethnobotany. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-49412-8_59.

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Conference papers on the topic "Crispa"

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Masuoka, T., T. Kawakami, T. Kiyoshima, et al. "Effect of pulsed discharges on mycelium growth of Sparassis crispa." In 2015 IEEE Pulsed Power Conference (PPC). IEEE, 2015. http://dx.doi.org/10.1109/ppc.2015.7296869.

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Muslimin, Lucia, Nurul Rezqi Hazrah, and Abdul Wahid Jamaluddin. "Sensitivity test of Escherichia coli againts extract of Tinospora crispa." In 1st International Conference in One Health (ICOH 2017). Atlantis Press, 2018. http://dx.doi.org/10.2991/icoh-17.2018.21.

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Musa, Weny A. J., Suleman Duengo, and Ahmad Kadir Kilo. "Campesterol compound from Methanol Fraction of Brotowali (Tinospora crispa) Stem Bark." In Proceedings of the National Seminar on Chemistry 2019 (SNK-19). Atlantis Press, 2019. http://dx.doi.org/10.2991/snk-19.2019.23.

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Erza, Nurul Nadifa, Fajriati Zulfa, and Yuni Setyaningsih. "Antifungal Test of the Ethanol Extract of Brotowali Stem (Tinospora Crispa) on the Growth of Trichophyton Rubrum in Vitro." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.05.02.

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ABSTRACT Background: Trichophyton rubrum is an infectious dermatophyte fungus which is the most common cause of dermatophytosis. Fungal resistance and the side effects of therapy are problems of antifungal agents. Phytochemical test of brotowali stem extract (Tinospora crispa) consist of flavonoids, phenols and triterpenoids which have antifungal effects. This study aimed to examine the effectiveness of brotowali stem extract (Tinospora crispa) as antifungal agent towards the growth of Trichophyton rubrum in vitro using agar well diffusion method. Subjects and Method: This was an experimental study using brotowali stem extract with concentration of 10%, 12,5%, 25%, 30%, 40%, 50%, 60%, 75%, and 100%. The dependent variable was Trichophyton rubrum growth. The independent variable was brotowali stem extract (Tinospora crispa). The data were obtained from the inhibition zone showed in agar well diffusion method in Sabouraud Dextrose Agar media. The data were analyzed using Kruskal-Wallis test. Results: The average diameter of inhibition zone of each variance (10%, 12,5%, 25%, 30%, 40%, 50%, 60%, 75%, and 100%) were 2.167 mm, 6.367 mm, 7.0 mm, 10.67 mm, 119 mm, 13.07 mm, 15.8 mm, 17.96 mm dan 17.13 mm, respectively, and they were statistically significant (p= 0.001). Conclusion: Brotowali stem extract has weak antifungal effectiveness at concentration 10%, 12,5%, 25%, intermediate antifungal effectiveness at concentration 30% and strong antifungal effectiveness at concentration 40%, 50%, 60%, 75% and 100%. Keywords: antifungal, brotowali stem, well diffusion, Trichophyton rubrum Correspondence: Fajriati Zulfa. Faculty of Medicine, Universitas Pembangunan Nasional ‘Veteran’ Jakarta. Jl. RS Fatmawati, Pondok Labu, Jakarta Selatan 12450, Telp. (021) 7656971. Email: nurulnerza@gmail.com DOI: https://doi.org/10.26911/the7thicph.05.02
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Hyun, TK, and H. Ju. "Variation of bioactive principles in different varieties of Perilla frutescens var. crispa." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3400113.

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Калина, Р. С., И. Н. Гладких, С. Пеньёр та ін. "Нейротоксины актинии Heteractis crispa : влияние на процессы активации и инактивации NaV каналов". У Актуальные проблемы химии и биологии. Федеральное государственное бюджетное учреждение науки Тихоокеанский институт биоорганической химии им. Г.Б. Елякова Дальневосточного отделения Российской академии наук, 2020. http://dx.doi.org/10.47471/17_2020_09_07_10_9.

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Zemiani, Adriana, Maria Tereza Betin, Marcelo Hidemassa Anami, and Alessandra Furtado da Silva. "AVALIAÇÃO DO DESENVOLVIMENTO DE Mentha Crispa L. CULTIVADA EM SOLO CONTAMINADO COM CÁDMIO." In IX SBEA + XV ENEEAmb + III FLES. Editora Blucher, 2017. http://dx.doi.org/10.5151/xveneeamb-030.

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Кветкина, А. Н., Л. А. Калужский, Е. А. Пислягин та ін. "Взаимодействие с сериновыми протеазами и нейропротективная активность IQ пептидов Кунитц-типа актинии Heteractis crispa". У Актуальные проблемы химии и биологии. Федеральное государственное бюджетное учреждение науки Тихоокеанский институт биоорганической химии им. Г.Б. Елякова Дальневосточного отделения Российской академии наук, 2020. http://dx.doi.org/10.47471/17_2020_09_07_10_11.

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Cotlet, Mircea, Satoshi Habuchi, Jennifer E. Whitier, et al. "Single molecule spectroscopic characterization of a far-red fluorescent protein (HcRed) from the Anthozoa coral Heteractis crispa." In Biomedical Optics 2006, edited by Alexander P. Savitsky and Rebekka Wachter. SPIE, 2006. http://dx.doi.org/10.1117/12.646811.

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Sina, Ibnu, Silviana Simbolon, Moh Sutoro, Sugiyarto Sugiyarto, and Alimah Ahmad. "Assessments: Toxicity Efficacy of Tinospora Crispa (Family: Menispermaceae) Against Macrotermes Gilvus (Family: Termitidae) in Oil Palm Plantation." In Proceedings of the 1st International Conference on Economics Engineering and Social Science, InCEESS 2020, 17-18 July, Bekasi, Indonesia. EAI, 2021. http://dx.doi.org/10.4108/eai.17-7-2020.2302970.

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Reports on the topic "Crispa"

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Pollack, Harold A., and Amy C. Watson. From Crisis to Care: Improved Second Response to Mental Health Crises. Milbank Memorial Fund, 2020. http://dx.doi.org/10.1599/mqop.2020.1203.

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Aguiar, Mark, Manuel Amador, Emmanuel Farhi, and Gita Gopinath. Crisis and Commitment: Inflation Credibility and the Vulnerability to Sovereign Debt Crises. National Bureau of Economic Research, 2013. http://dx.doi.org/10.3386/w19516.

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Bordo, Michael, and Harold James. The European Crisis in the Context of the History of Previous Financial Crises. National Bureau of Economic Research, 2013. http://dx.doi.org/10.3386/w19112.

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Kennedy, Adam, and Danielle Resnick. Governing a crisis and crises of governance: The political dimensions of COVID-19. International Food Policy Research Institute, 2021. http://dx.doi.org/10.2499/p15738coll2.134324.

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Sandleris, Guido, and Mark L. J. Wright. The Costs of Financial Crises: Resource Misallocation, Productivity and Welfare in the 2001 Argentine Crisis. National Bureau of Economic Research, 2011. http://dx.doi.org/10.3386/w17552.

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Matthew Fischer, Matthew Fischer. CRISPR Cas9 testing model. Experiment, 2018. http://dx.doi.org/10.18258/11380.

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Kang, Jiyun, Woo Jin Choi, and Tiffani Slaten. Felt Betrayed or Resisted? The Impact of Pre-Crisis CSR Reputation on Consumer Reactions to Brand Crises. Iowa State University. Library, 2019. http://dx.doi.org/10.31274/itaa.8234.

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Chang, Roberto. Financial Crises and Political Crises. National Bureau of Economic Research, 2005. http://dx.doi.org/10.3386/w11779.

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Frankel, Jeffrey, and George Saravelos. Are Leading Indicators of Financial Crises Useful for Assessing Country Vulnerability? Evidence from the 2008-09 Global Crisis. National Bureau of Economic Research, 2010. http://dx.doi.org/10.3386/w16047.

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Storck, Brian W. The Coming Crisis in Crisis Planning. Defense Technical Information Center, 2000. http://dx.doi.org/10.21236/ada381620.

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