Relevant bibliographies by topics / Crohn's disease ; inflammatory bowel diseases / Dissertations / Theses
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Dissertations / Theses on the topic 'Crohn's disease ; inflammatory bowel diseases'

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Published: 4 June 2021
Last updated: 10 February 2022

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1

Phillips, Anne Mairead. "Investigation of the phenotypic and genotypic determinants of disease susceptibility and progression in Crohn's Disease." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/9473.

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The inflammatory bowel diseases (IBD), encompassing Crohn’s disease (CD) and ulcerative colitis (UC), are chronic inflammatory disorders of the gastrointestinal tract. Their aetiology is not fully understood but is thought to be a combination of the effect of environmental factors in a genetically susceptible person. The work presented is an examination of the phenotypic characteristics of CD in the Scottish population, and an investigation into genetic factors that may influence susceptibility and progression. An IBD cohort from Dundee was recruited (CD=367, UC=265), and extensive phenotypic
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2

Collins, Carole Elizabeth. "Platelet dysfunction in inflammatory bowel disease." Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362539.

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3

Rankin, B. J. "Colonic mucus in inflammatory bowel disease." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320821.

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4

Gerasimidis, Konstantinos. "Nutritional aspects and gut microbiota in paediatric inflammatory bowel disease." Thesis, Thesis restricted. Connect to e-thesis to view abstract, 2009. http://theses.gla.ac.uk/826/.

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Thesis (Ph.D.) - University of Glasgow, 2009.<br>Ph.D. thesis submitted to the Division of Developmental Medicine, Faculty of Medicine, University of Glasgow, 2009. Includes bibliographical references. Print version also available.
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5

Cotterill, Lynn. "Inflammatory bowel disease genetics." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/inflammatory-bowel-disease-genetics(daae1a60-2790-4280-b7d5-ac5ec7533c7c).html.

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Inflammatory bowel disease (IBD), which includes the subtypes Crohn's disease (CD) and ulcerative colitis (UC), is a common disease particularly in the Western world. IBD is characterised by inflammation of the small intestine and/or colon. The two subtypes affect different gut locations but both show an increased intestinal permeability or the 'leaky gut syndrome'. This led to the hypothesis that tight junction (TJ) proteins expressed in the epithelium may affect the intestinal permeability as a cause or effect of IBD.Initially, variants in the CARD15, IL23R and ATG16L1 genes, previously asso
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6

Kamperidis, Nikolaos. "Nutrient effects in inflammatory bowel disease." Thesis, Queen Mary, University of London, 2016. http://qmro.qmul.ac.uk/xmlui/handle/123456789/23488.

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Background: Not only does IBD lead to nutritional deficiencies, but also nutrients influence its pathophysiology: exclusive enteral nutrition (EEN) is an effective primary treatment in Crohn's disease; and vitamin D (VitD) is involved in its pathogenesis and course. Aims: We hypothesised that nutrients impact on the course of IBD. We therefore studied the effect of EEN i) on long term clinical course in children; ii) on CD58, a costimulatory molecule at the intestinal epithelial cell (IEC) lines, iii) adults with Crohn's disease. We examined the possible effect of serum vitamin D levels on the
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7

Baker, John Summers. "The function of innate immune genes in Crohn's disease." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.560924.

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Crohn's Disease (CD) is a debilitating condition characterised by chronic intermittent intestinal inflammation. More than 90 genetic polymorphisms are associated with CD susceptibility, including several in genes of the innate immune system. Here I present a series of experiments designed to enhance our knowledge of the roles of CD-associated polymorphisms in pathogenesis. Many therapeutic regimens are employed in CD treatment, but patients' responses to treatment and disease progression vary widely. There is great interest in studying whether analysis of patients' genotype at CD-associated po
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8

Johnston, Colette. "Metabolomic profiling in inflammatory bowel disease." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/metabolomic-profiling-in-inflammatory-bowel-disease(1eb7a48f-af12-4bd2-8497-ebad4eae0e4e).html.

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Introduction: Inflammatory bowel disease is a common, complex relapsing disorder characterised by immune dysregulation, altered intestinal permeability and microbial insult. Limited knowledge is available regarding the metabolic changes observed during progression of the disease, and limited biomarkers of disease available that have been validated and shown to be of sound clinical value. Aim of Study: A two stage metabolomics approach was adopted to determine if metabolic signature profiles, could distinguish inflammatory bowel disease Crohn’s disease (CD) patients from ulcerative colitis (UC)
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9

Simmons, Jonathan David. "Candidate genes in inflammatory bowel disease - defining susceptibility, disease phenotype and long term outcome." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249575.

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10

Thompson, Nicholas Paul. "An epidemiological assessment of early risk factors for Crohn's disease." Thesis, Queen Mary, University of London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309308.

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11

Kalla, Rahul. "Biomarker discovery in inflammatory bowel diseases." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31040.

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There is an unmet need for novel biomarker discovery in Inflammatory Bowel Diseases (IBD) to aid clinical management in several clinical settings including diagnosis and prognosis. With an ever-advancing repertoire of biological therapies on the horizon, it is important to personalise treatments at an early stage. The aim of this thesis is to explore the clinical utility of novel blood-based biomarkers in diagnosis, disease classification and prognosis in 2 cohorts: newly diagnosed IBD and acute severe colitis. Investigating the circulating methylome, 290 probes exhibited Holm significant IBD-
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12

de, Lange Katrina Melanie. "Understanding inflammatory bowel disease using high-throughput sequencing." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/265370.

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For over two decades, the study of genetics has been making significant progress towards understanding the causes of common disease. Across a wide range of complex disorders there have been hundreds of associated loci identified, largely driven by common genetic variation. Now, with the advent of next-generation sequencing technology, we are able to interrogate rare and low frequency variation in a high throughput manner for the first time. This provides an exciting opportunity to investigate the role of rarer variation in complex disease risk on a genome-wide scale, potentially o↵ering novel
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13

Mottawea, Walid Abd El-Fattah El-Sayed. "Microbiota-Host Symbiosis In First-Onset Pediatric Inflammatory Bowel Disease." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32125.

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In recent years, the association between inflammatory bowel diseases (IBDs) and gut microbiota has been extensively studied in adults using post-treatment cohorts of patients. However, microbial composition and functional interplay between host genetics and microorganisms in newly diagnosed early IBD onset remain poorly defined. Using colonoscopic mucosal washes to collect mucosal-luminal microbiota from different intestinal locations, we studied the gut microbiome in a large number of children with either Crohn’s disease (CD) or ulcerative colitis (UC). Although no significant difference in t
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14

Ventham, Nicholas Toby. "Epigenetic biomarker discovery in inflammatory bowel disease : unearthing clues for disease pathogenesis?" Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/23608.

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Epigenetic alterations including DNA methylation and microRNAs may provide important insights into gene-environment interaction in complex immune diseases such as inflammatory bowel disease (IBD). An integrative genome-wide approach was used to analyse whole blood genetic, DNA methylation and gene expression data in 240 newly diagnosed IBD patients and 190 controls. Using the Illumina 450k array, differences in whole blood DNA methylation were observed in IBD cases versus controls including 439 differentially methylated positions (DMPs) and 5 differentially methylated regions (DMRs). The top D
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15

Ellis, Richard David. "Activation of the transcription factor nuclear factor kappa B in Crohn's disease." Thesis, King's College London (University of London), 2000. https://kclpure.kcl.ac.uk/portal/en/theses/activation-of-the-transcription-factor-nuclear-factor-kappa-b-in-crohns-disease(392a2a2a-0fbd-4cfd-b037-5a0d07d5bc5e).html.

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16

Barahona, Megan. "Nutrition and Inflammatory Bowel Disease| A curriculum for patients with Crohn's disease and ulcerative colitis." Thesis, California State University, Long Beach, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10142988.

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<p> Targeted nutrition therapy aimed at reducing inflammation through diet is highly underutilized in the standard treatment of Inflammatory Bowel Disease (IBD). Therefore, the purpose of this directed project was to develop a nutrition curriculum for patients diagnosed with IBD. Specifically, the curriculum consists of five 30-minute PowerPoint presentations with corresponding lesson plans and topic-specific activities and provides specific nutrition recommendations for reducing inflammation and maintaining remission of IBD. </p><p> An expert panel comprised of two registered dietitians and
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17

Loughlin, Mark. "Characterisation and study of unclassified bacteria cultured from inflammatory bowel disease tissues." Thesis, St George's, University of London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297208.

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18

Salim, Sa'ad Yislam. "Mucosal dendritic cells in inflammatory bowel disease." Doctoral thesis, Linköpings universitet, Kirurgi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-52234.

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Crohn's disease, a chronic inflammation of the bowel, is a multi-factorial condition where uncontrolled immune responses to luminal bacteria occur in genetically predisposed individuals. The first observable clinical signs are small ulcers that form at a specialised form of epithelium, follicle-associated epithelium (FAB). The FAB covers immune inductive sites, Peyer's patches, which function primarily as sensory areas that sample the externaI gut environment. Dendritic cells are one of the key cells that are involved in sensing luminal contents and orchestrating the gut immune system. The mai
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19

Boyapati, Ray Kiran. "Mitochondrial damage-associated molecular patterns (DAMPs) in inflammatory bowel disease." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/33169.

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Background The inflammatory bowel diseases (IBD) ulcerative colitis (UC) and Crohn's disease (CD) are chronic relapsing inflammatory disorders which have a rising incidence and cause significant morbidity. There are currently several treatment options with many more in the drug pipeline, but there are a lack of accurate biomarkers for decisions on treatment choice, assessment of disease activity and prognostication. There is a growing interest and desire for personalised or 'precision' medicine in IBD where novel biomarkers may help individualise IBD care in terms of diagnosis, choice of thera
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20

Bresso, Francesca. "Genetic and molecular determinants in inflammatory bowel disease /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-982-3/.

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21

Halfvarson, Jonas. "Inflammatory bowel disease in twins : studies of genetics and environmental factors /." Linköping : Univ, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/med909s.pdf.

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22

Schoultz, Mariyana. "The use of mindfulness-based cognitive therapy for patients with inflammatory bowel disease." Thesis, University of Stirling, 2016. http://hdl.handle.net/1893/23931.

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Background: Inflammatory Bowel Disease (IBD) is a group of chronic gastrointestinal diseases with a relapsing nature. The two main types are Crohn’s disease (CD) and ulcerative colitis (UC). Both CD and UC patients experience very similar and distressing symptoms: acute abdominal pain, vomiting, malnutrition, fever, fatigue, diarrhoea and rectal bleeding. These symptoms are disabling and have a severe impact on physical and psychosocial wellbeing. Around 30% of patients suffer from moderate to severe psychological distress and have difficulties coping with the illness even in remission. Howeve
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23

Adams, Leanne M. "MOLECULAR TYPING OF MYCOBACTERIAL ISOLATES CULTURED FROM THE TISSUE OF INFLAMMATORY BOWEL DISEASE (CROHN'S DISEASE) PATIENTS." Master's thesis, University of Central Florida, 2004. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4450.

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The role of Mycobacterium avium subsp paratuberculosis (MAP) in the etiology and pathogenesis of inflammatory bowel disease (IBD) including Crohn's Disease (CD), has been investigated. The fastidious characteristics and cross reactivity of MAP with other members in Mycobacteria have produced significant challenges in their detection and identification. In this two year pilot study, an array of three PCR molecular assays based on the detection of sequences from the16S rRNA, IS1245, and IS900 genes, belonging to members of the MAC, have been developed and optimized into a common protocol to be u
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24

Wahed, Mahmood. "Psychological stress and its therapeutical implications in inflammatory bowel disease." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8724.

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There is increasing evidence that psychological stress and associated mood disorders are linked with, and can adversely affect the course of inflammatory bowel disease (IBD). Stress is perceived to be relieved by smokers, and this, like a lack of knowledge about its adverse effects, and nicotine dependence, could contribute to continued smoking by patients with Crohn’s disease (CD). Stress has previously been shown to influence disease course in patients with inactive ulcerative colitis (UC) but its influence in acute severe UC is not known. Emerging trial evidence supports the suggestion that
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25

Thomas, Gillian B. "The place of counselling in the care of people affected by inflammatory bowel disease." Thesis, University of Reading, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337667.

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26

Keita, Åsa. "Barrier function of the follicle-associated epithelium in stress and Crohn's disease /." Linköping : Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-9271.

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27

Henderson, Paul. "Paediatric inflammatory bowel disease : bench to bedside and nationwide : a detailed analysis of Scottish children with IBD." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/12235.

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The inflammatory bowel diseases (IBDs) are a group of chronic conditions affecting the gastrointestinal tract, often presenting with non-specific clinical features such as abdominal pain, weight loss and diarrhoea. Approximately 25% of patients are diagnosed with IBD in childhood. For epidemiological studies, previously collected (1990-1995) and original (2003-2008) Scottish incidence data were used to determine national trends in newly diagnosed paediatric IBD (PIBD). A smaller, geographically defined, prospective 14-year cohort (1997- 2011) in South-East Scotland (SES) was used to assess reg
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28

Yang, ShinChieh. "POSSIBLE USE OF P20 ANTIGEN IN SERODIAGNOSIS OF INFLAMMATORY BOWEL DISEASE." Master's thesis, University of Central Florida, 2004. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4364.

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Crohn's disease (CD) is an idiopathic, chronic, relapsing inflammatory disorder, which is most commonly involved terminal ileum and colon. The incidence and prevalence of CD has dramatically increased during the last 50 years; however, the etiology and mechanism of this disorder remain unveiled. Besides genetic susceptibility, recent integrated researches investigated the role of environmental triggers such as microflora, measles viruses and mycobacteria in the pathogenesis of CD. The association between M. avium subsp paratuberculosis (MAP) and CD has been heightened because of clinical resem
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29

Flood, Lars. "Glucocorticosteroid therapy and steroid resistance in inflammatory bowel disease /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-020-6/.

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30

Soroosh, Artin. "The Role of KIAA1199 in Crohn's Disease." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1396386453.

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31

Bloom, Stuart. "Adhesion molecules in the gastrointestinal tract : a search for cell surface molecules upregulated in inflammatory bowel disease." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239338.

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32

Oxelmark, Lena. "Quality of life in inflammatory bowel diseases: aspects on interventions and unconventional treatments /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-655-7/.

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33

Abujamel, Turki. "Characterization of Gut Butyrate Producers and Plasmidome in First-onset Pediatric Inflammatory Bowel Disease." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34271.

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Inflammatory bowel disease (IBD) is a growing disorder with unknown etiology. However, increasing evidence strongly highlights the role of gut microbiota with possible involvement of microbial plasmidome in the inflammatory process. Although the composition of the gut microbiota has been extensively studied, important functional groups such as butyrate producers remain poorly characterized, particularly in pediatric IBD. Furthermore, evaluation of the gut plasmidome in healthy and IBD children is missing. In this study, we used molecular techniques involving quantitative PCR (qPCR) and next-ge
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34

Lundberg, Sofie. "Nitric oxide and evaluation of different treatments in experimental colitis and inflammatory bowel disease /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-930-0/.

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35

Sjöberg, Daniel. "The Inflammatory Bowel Disease Cohort of the Uppsala Region (ICURE) : Epidemiology and Complications." Doctoral thesis, Uppsala universitet, Gastroenterologi/hepatologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-241584.

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The overall aims of this thesis were to investigate the incidence of inflammatory bowel disease in the Uppsala Region of Sweden, to study the clinical course and the impact of the disease with regards to complications. Patients in Uppsala County were included in the study from the 1st of January 2005 and patients in Falun, Eskilstuna and Åland counties from the 1st of January 2007. The study was closed for all centres on the 31st of December 2009. Mean population in the study region was 305,381 in 2005–2006 and 642,117 in 2007–2009. The mean incidence for ulcerative colitis (UC) during the tim
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36

Hernández, Teruel Adrián. "Smart drug delivery systems designed to improve Inflammatory Bowel Disease therapy." Doctoral thesis, Universitat Politècnica de València, 2019. http://hdl.handle.net/10251/129863.

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[ES] La presente tesis doctoral titulada "Sistemas de liberacio'n controlada de fa'rmacos diseñados para mejorar el tratamiento de Enfermedad Inflamatoria Intestinal" se centra en el diseño, preparación, caracterización y evaluación in vivo de distintos sistemas de liberación controlada de fármacos en colon (CDDS, por sus siglas en inglés) utilizando como soporte micropartículas de silice mesoporosa, funcionalizadas con puertas moleculares. En conclusión, los estudios realizados demuestran que los materiales de silice mesoporosa, en combinación con puertas moleculares sensibles a estímulos es
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37

Martinsson, Sandra, and Dijana Slijepcevic. "Att leva med en inflammatorisk tarmsjukdom." Thesis, Högskolan Väst, Institutionen för omvårdnad, hälsa och kultur, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-5440.

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Background: Inflammatory bowel disease (IBD) is an umbrella term for ulcerative colitis and Crohn's disease. These are characterized by a chronic inflammation of the intestinal mucosa. Living with chronic illness meant that life changed significantly. Quality of life was affected for these individuals and was stressful in their lives.   Aim: The aim was to describe the experiences of living with inflammatory bowel disease.   Method: A qualitative literature review was chosen to analyze articles that were related to the aim of this study.   Results: Based on the chosen articles five themes were
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38

Almeida, Ana Cristina Alves de 1982. "Avaliação do efeito do alcaloide índigo em modelos experimentais de colite." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/315768.

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Orientador: Alba Regina Monteiro Souza Brito<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-26T17:16:46Z (GMT). No. of bitstreams: 1 Almeida_AnaCristinaAlvesde_D.pdf: 2447485 bytes, checksum: 029d5569d7c4d1eaaffa8f4a530937dd (MD5) Previous issue date: 2015<br>Resumo: A Doença Inflamatória Intestinal (DII), que compreende a Doença de Crohn (DC) e a Retocolite Ulcerativa (RCU), é marcada por resposta inflamatória exacerbada a componentes da microbiota, com danos à mucosa do cólon. O tratamento de DII envolve drogas ineficaz
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39

Walmsley, Russell Stuart. "Studies of the prevalence and the clinical and pathological relevance of anti-bactericidal/permeability-increasing protein autoantibodies in inflammatory bowel disease and primary sclerosing cholangitis." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311380.

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40

Fanokhyar, Forough. "An epidemiological study of inflammatory bowel disease : (incidence, mortality, short-term and long-term prognosis in three centres in England during the years 1977-93)." Thesis, University of Wolverhampton, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321594.

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Both ulcerative colitis and Crohn's disease are chronic disorders of unknown aetiology. The purpose of this study was to map the incidence and current natural history of both diseases so that this knowledge might assist in the better management of patients. The study is of a cohort of 723 patients with inflammatory bowel disease diagnosed in Wolverhampton, Salisbury and Swindon between 1977-86 and followed up prospectively until 31st December 1993. The incidence, mortality, survival and short-term prognosis in relation to age, sex, length of history, severity and extent of disease were analyse
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Sabe, Victor T. "The association between environmental exposures during childhood and the subsequent development of crohn's disease in the Western Cape." Thesis, University of the Western Cape, 2015. http://hdl.handle.net/11394/5341.

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Magister Scientiae (Medical Bioscience) - MSc(MBS)<br>Background: A subtype of inflammatory bowel disease, Crohn’s disease is thought to represent a complex interaction between environmental factors, a defective immune system, the gastrointestinal microbiome and genetic susceptibility. Aim: The focus of this study was to investigate the association between environmental exposures during childhood and the subsequent development of Crohn’s disease, thus the two primary aims were to: 1) conduct a systematic review of the literature evaluating environmental risk factors during childhood, defined
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Coppi, Luciane Cristina. "Avaliação da atividade de eosinofilos perifericos em pacientes com doenças inflamatorias intestinais." [s.n.], 2004. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310036.

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Orientador: Jose Geraldo P. Ferraz<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-06T17:03:45Z (GMT). No. of bitstreams: 1 Coppi_LucianeCristina_D.pdf: 5991264 bytes, checksum: bbcad7dd36b02092b27ac1c30b751988 (MD5) Previous issue date: 2004<br>Resumo: Os eosinófilos estão envolvidos na patogênese de várias doenças inflamatórias crônicas? incluindo doenças inflamatórias intestinais (Dll)? como doença de Crohn (DC) e retocolite ulcerativa inespecífica (RCVI). No entanto? ainda é desconhecido como os eosinófilos con
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43

Honzawa, Yusuke. "Involvement of interleukin-17A-induced expression of heat shock protein 47 in intestinal fibrosis in Crohn's disease." Kyoto University, 2014. http://hdl.handle.net/2433/189671.

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44

Veny, Alvarez-Ossorio Marisol. "Nous mediadors de la resposta T efectora en la malaltia inflamatòria intestinal." Doctoral thesis, Universitat de Barcelona, 2010. http://hdl.handle.net/10803/37032.

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La malaltia de Crohn és una malaltia inflamatòria intestinal de base immunitària. L’etiologia de la malaltia és desconeguda, encara que en general s’admet la següent definició: la malaltia és conseqüència d’una desregulació de la resposta immunitària en front als antígens comuns de la flora bacteriana intestinal en individus genèticament susceptibles. Un component important de la desregulació immunitària es la hiperactivació dels limfòcits T que es dóna en aquesta i altres malalties de tipus autoimmunitari, i en les que tradicionalment s’ha atribuït una major presència i producció de citoc
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Antunes, Carla Valéria de Alvarenga. "Anemia nas doenças inflamatórias intestinais: prevalência e fatores de risco." Universidade Federal de Juiz de Fora, 2014. https://repositorio.ufjf.br/jspui/handle/ufjf/461.

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Submitted by Renata Lopes (renatasil82@gmail.com) on 2016-01-21T16:51:59Z No. of bitstreams: 1 carlavaleriadealvarengaantunes.pdf: 1487917 bytes, checksum: c0d630797135f7fb32b18c3ae9000d7c (MD5)<br>Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2016-01-25T18:46:52Z (GMT) No. of bitstreams: 1 carlavaleriadealvarengaantunes.pdf: 1487917 bytes, checksum: c0d630797135f7fb32b18c3ae9000d7c (MD5)<br>Made available in DSpace on 2016-01-25T18:46:52Z (GMT). No. of bitstreams: 1 carlavaleriadealvarengaantunes.pdf: 1487917 bytes, checksum: c0d630797135f7fb32b18c3
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Trauernicht, Anna. "Genetic Variation in Janus Associated Kinase 2 and Signal Transducers and Activators of Transcription 3 is Associated with Granulocyte-Macrophage Colony Stimulating Factor Auto-antibodies in Pediatric Crohn’s Disease." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1321370394.

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47

Ambrose, Timothy James William. "Serine hydrolase activity and roles for monoacylglycerol lipase in innate immunity and intestinal inflammation." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:f7a12796-ae8f-4121-ab1a-26778261ac78.

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Detection of evolutionarily conserved pathogen motifs by pattern recognition receptors (PRRs), particularly on dendritic cells (DCs), is crucial for adequate immune responses. Defects in DC function are known to be associated with inflammatory bowel disease (IBD). The endocannabinoid system (ECS) is the system through which exocannabinoids such as Δ<sup>9</sup>-tetrahydrocannabinol and cannabidiol signal. Regarding inflammation, cannabinoids generally exert anti-inflammatory effects, including on experimental colitis. However, most work has been performed in animal models and less is known abo
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48

Johansson, Amanda, and Johanna Modin. "Livet som kroniskt sjuk : Unga kvinnors erfarenheter av att leva med en inflammatorisk tarmsjukdom. En kvalitativ studie av bloggar." Thesis, Högskolan i Skövde, Institutionen för hälsa och lärande, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-12173.

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Bakgrund: Majoriteten av de som drabbas av inflammatorisk tarmsjukdom är kvinnor. Att drabbas vid ung ålder kan öka problematiken. Det finns luckor i forskningen om de psykosociala faktorernas inverkan. Kronisk sjukdom skapar ofta lidande och för att kunna hantera det på ett värdigt sätt krävs kunskap och förståelse. Patienternas erfarenheter om sin sjukdom genererar en bättre inblick och ökad förståelse för sjuksköterskan. Kunskapen hjälper sjuksköterskor att erbjuda god vård för att patienten ska kunna uppleva en så bra livskvalité som möjligt. Syfte: Syftet med denna studie var att belysa u
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49

MacDonald, Erika. "Exploration of Post-market Evidence of Effectiveness and Safety of TNF-alpha Inhibitors in Crohn’s and Colitis." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/33416.

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The objectives of this thesis were to synthesize existing RCT evidence and post-market observational evidence of TNF-α inhibitors in IBD. Two separate systematic reviews were performed: an overview of systematic reviews of RCTs, and a systematic review of post-market observational studies of TNF-α inhibitors in Crohn’s disease and ulcerative colitis. The overview of systematic reviews included 37 studies. RCT evidence demonstrated superiority of all agents to placebo in Crohn’s disease and ulcerative colitis, with no increased risk of malignancy or serious adverse events. Network meta-analyses
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50

Keita, Åsa. "Barrier function of the Follicle-Associated Epithelium in Stress and Crohn's disease." Doctoral thesis, Linköpings universitet, Kirurgi, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-9271.

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Crohns sjukdom är en kronisk inflammatorisk tarmsjukdom av okänd orsak. Det tidigaste tecknet på Crohns sjukdom är mikroskopiska sår i det s.k. follikelassocierade epitelet (FAE) som täcker ansamlingar av immunceller i tarmen. FAE är specialiserat för att fånga innehåll från tarmen och transportera det till underliggande immunvävnad. Denna funktion är viktig för att inducera skyddande immunsvar, men den utgör också en ingångsväg för sjukdomsalstrande bakterier. Crohns sjukdom är associerat med ett kraftigt ökat immunsvar mot bakterier, och sjukdomsförloppet kan ändras av stress. Det övergripan
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