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1

Arnott, I. D. R. "Crohn's disease or Crohn's diseases?" Gut 52, no. 4 (April 1, 2003): 460–61. http://dx.doi.org/10.1136/gut.52.4.460.

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2

Haubich, William S. "Crohn of Crohn's disease." Gastroenterology 116, no. 5 (May 1999): 1034. http://dx.doi.org/10.1016/s0016-5085(99)70056-9.

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3

Catalin, Popescu Razvan, Leopa Nicoleta, Micu Luminita Gentiana, Costea Daniel Ovidiu, Olteanu Cornelia Minodora, Ciobanu Florin, and Dumitru Andrei. "Colon Cancer in Patients with Crohn’s Disease and Diabetes Mellitus." ARS Medica Tomitana 26, no. 3 (August 1, 2020): 150–53. http://dx.doi.org/10.2478/arsm-2020-0030.

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Abstract Introduction: Diabetes mellitus and colorectal cancer are diseases with an increasing impact on the population. Colorectal cancer is a well-recognized complication of inflammatory bowel diseases, such as ulcerative colitis and Crohn’s colitis. Here we describe an unusual case of diabetes mellitus, Crohn`s colitis-associated cancer. Case report: We report the case of a 49-year-old woman, known with Crohn's disease and diabetes, who developed a transverse colon adenocarcinoma associated with multiple outbreaks of high-grade or low-grade intraepithelial dysplasia/neoplasia, for which a subtotal proctocolectomy with ileorecto-anastomosis with “J” pouch it was made. Conclusions: The risk of colonic carcinoma in Crohn's disease is increasing. An association of colorectal cancer with diabet mellitus and inflammatory bowel disease has been established. From diagnosis to treatment the management of these cases can be difficult and challenging.
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4

Ainley, C. C., J. Cason, L. K. Carlsson, B. M. Slavin, and R. P. H. Thompson. "Zinc status in inflammatory bowel disease." Clinical Science 75, no. 3 (September 1, 1988): 277–83. http://dx.doi.org/10.1042/cs0750277.

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1. The zinc contents of plasma, erythrocytes, polymorphonuclear leucocytes and mononuclear leucocytes from 18 normal control subjects, 31 patients with Crohn's disease and 15 patients with ulcerative colitis were measured. 2. Plasma zinc levels were low in Crohn's disease, particularly in malnourished patients, and related to plasma albumin concentrations, but were normal in ulcerative colitis. 3. Erythrocyte zinc levels were normal in both Crohn's disease and ulcerative colitis. 4. Mean polymorphonuclear leucocyte zinc levels were normal in Crohn‘s disease and ulcerative colitis. Ten per cent of Crohn's disease patients had subnormal levels, which were associated with inactive disease, while 10% had elevated levels, which were associated with active disease. Seven per cent of ulcerative colitis patients had subnormal levels. Mononuclear leucocyte zinc levels were normal in Crohn's disease and in ulcerative colitis. 5. Tissue zinc depletion occurs in only a few patients with Crohn's disease and ulcerative colitis.
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5

Rożalski, Michał. "Extraintestinal Crohn's disease (metastatic Crohn's disease)." Dermatology Review 5 (2014): 418–22. http://dx.doi.org/10.5114/dr.2014.46074.

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6

Sachdev, Ritu, and David R. Cave. "When Is Crohn's Disease Crohn's Disease?" Inflammatory Bowel Diseases 10, no. 1 (January 2004): 63. http://dx.doi.org/10.1097/00054725-200401000-00012.

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7

Nurul Utami, Herdiana, Ira Munirah, Latifah Mukhlisatunnafsi, Marwa Zileikhadira Manzalina, Yusra Pintaningrum, and Jaini Rahma. "CROHN DISEASE: Patofisiologi, Diagnosis, dan Penatalaksanaan." Lombok Medical Journal 2, no. 1 (May 15, 2023): 5–13. http://dx.doi.org/10.29303/lmj.v2i1.2340.

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ABSTRAK Penyakit Crohn adalah kondisi radang usus idiopatik kronis, ditandai dengan lesi, yang dapat memengaruhi seluruh saluran cerna mulai dari mulut hingga anus. Insiden tahunan penyakit crohn mencapai 3 hingga 20 kasus per 100.000 dengan usia rata-rata 30 tahun. Patofisiologi penyakit crohn didasarkan pada peradangan jaringan oleh respons imun yang tidak dapat dikendalikan terhadap antigen bakteri. Penegakan diagnosis dengan Computed tomography (CT), magnetic resonance imaging (MRI), dan ultrasonografi menjadi standar diagnosis dari penyakit crohn. Prognosis dari penyakit crohn ini tergantung dari komplikasi yang muncul seperti fistula dan bowel obstruction usus serta kondisi remisi dari pasien, ataupun tingkat respon tiap pasien terhadap pengobatan sehingga dalam menangani penyakit crohn adalah mengobati kondisi peradangan aktif hingga cepat mengalami remisi dan mempertahankannya selama mungkin. Kata Kunci: crohn disease; patofisiologi; diagnosis; penatalaksanaan; prognosis ABSTRACT Crohn's disease is a chronic idiopathic inflammatory bowel condition, characterized by lesions, which can affect the entire gastrointestinal tract from the mouth to the anus. The annual incidence of Crohn's disease is 3 to 20 cases per 100,000 with a median age of 30 years. The pathophysiology of Crohn's disease is based on tissue inflammation by an uncontrollable immune response to bacterial antigens. Computed tomography (CT), magnetic resonance imaging (MRI), and ultrasonography have become the standard for the diagnosis of Crohn's disease. The prognosis of Crohn's disease depends on complications such as enteric fistula and intestinal neoplasia and the condition of remission of the patient, or the level of response of each patient to treatment so that in treating Crohn's disease is to treat the active inflammatory condition until it goes into remission quickly and maintain it as long as possible. Keyword: crohn disease; pathophysiology; diagnosis; treatment; prognosis
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8

Karateke, Faruk, Ebru Menekşe, Koray Das, Sefa Ozyazici, and Pelin Demirtürk. "Isolated Duodenal Crohn's Disease: A Case Report and a Review of the Surgical Management." Case Reports in Surgery 2013 (2013): 1–3. http://dx.doi.org/10.1155/2013/421961.

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Crohn's disease may affect any segment of the gastrointestinal tract; however, isolated duodenal involvement is rather rare. It still remains a complex clinical entity with a controversial management of the disease. Initially, patients with duodenal Crohn' s disease (DCD) are managed with a combination of antiacid and immunosuppressive therapy. However, medical treatment fails in the majority of DCD patients, and surgical intervention is required in case of complicated disease. Options for surgical management of complicated DCD include bypass, resection, or stricturoplasty procedures. In this paper, we reported a 33-year-old male patient, who was diagnosed with isolated duodenal Crohn’s diseases, and reviewed the surgical options in the literature.
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9

Pal, Anirban. "Crohn's disease." InnovAiT: Education and inspiration for general practice 7, no. 1 (November 20, 2013): 43–54. http://dx.doi.org/10.1177/1755738013512118.

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10

Brinberg, Don E., and Barbara E. Berkeley. "Crohn's disease." Postgraduate Medicine 86, no. 5 (October 1989): 257–65. http://dx.doi.org/10.1080/00325481.1989.11704450.

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11

de Saussure, Philippe, and Claudio Soravia. "Crohn's Disease." New England Journal of Medicine 352, no. 21 (May 26, 2005): 2222. http://dx.doi.org/10.1056/nejmicm041035.

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12

&NA;. "Crohn's disease." Diseases of the Colon & Rectum 52, no. 1 (January 2009): 180–81. http://dx.doi.org/10.1097/01.dcr.0000345742.94130.36.

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13

&NA;. "Crohn's disease." Diseases of the Colon & Rectum 52, no. 4 (April 2009): 762. http://dx.doi.org/10.1097/01.dcr.0000345772.48389.45.

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14

Hampson, S. J. "Crohn's Disease?" Scottish Medical Journal 33, no. 1 (February 1988): 216–17. http://dx.doi.org/10.1177/003693308803300114.

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15

Jewell, Derek P. "Crohn's Disease." Medicine 31, no. 2 (February 2003): 76–81. http://dx.doi.org/10.1383/medc.31.2.76.28609.

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16

Folwaczny, Christian, Jürgen Glas, and Helga-Paula Török. "Crohn's disease." European Journal of Gastroenterology & Hepatology 15, no. 6 (June 2003): 621–26. http://dx.doi.org/10.1097/00042737-200306000-00007.

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17

Fellermann, Klaus, Jan Wehkamp, Klaus R. Herrlinger, and Eduard F. Stange. "Crohn's disease." European Journal of Gastroenterology & Hepatology 15, no. 6 (June 2003): 627–34. http://dx.doi.org/10.1097/00042737-200306000-00008.

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18

Ballester Ferré, María Pilar, Marta Maia Boscá-Watts, and Miguel Mínguez Pérez. "Crohn's disease." Medicina Clínica (English Edition) 151, no. 1 (July 2018): 26–33. http://dx.doi.org/10.1016/j.medcle.2018.05.006.

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19

Jewell, Derek P. "Crohn's disease." Medicine 35, no. 5 (May 2007): 283–89. http://dx.doi.org/10.1016/j.mpmed.2007.02.001.

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20

Hart, Ailsa L., and Siew C. Ng. "Crohn's disease." Medicine 43, no. 5 (May 2015): 282–90. http://dx.doi.org/10.1016/j.mpmed.2015.02.006.

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21

Mak, Wing Yan, Ailsa L. Hart, and Siew C. Ng. "Crohn's disease." Medicine 47, no. 6 (June 2019): 377–87. http://dx.doi.org/10.1016/j.mpmed.2019.03.007.

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22

Shanahan, Fergus. "Crohn's disease." Lancet 359, no. 9300 (January 2002): 62–69. http://dx.doi.org/10.1016/s0140-6736(02)07284-7.

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23

Wexner, Steven. "Crohn's Disease." Clinics in Colon and Rectal Surgery 20, no. 4 (November 2007): 267–68. http://dx.doi.org/10.1055/s-2007-991025.

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24

Loftus, Edward V. "Crohn's Disease." Gastroenterology Clinics of North America 46, no. 3 (September 2017): i. http://dx.doi.org/10.1016/s0889-8553(17)30073-0.

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25

Torres, Joana, Saurabh Mehandru, Jean-Frédéric Colombel, and Laurent Peyrin-Biroulet. "Crohn's disease." Lancet 389, no. 10080 (April 2017): 1741–55. http://dx.doi.org/10.1016/s0140-6736(16)31711-1.

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26

Block, George E., Fabrizio Michelassi, Masanori Tanaka, Robert H. Riddell, and Stephen B. Hanauer. "Crohn's disease." Current Problems in Surgery 30, no. 2 (February 1993): 183–265. http://dx.doi.org/10.1016/0011-3840(93)90035-f.

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27

Leikin, Jerrold B. "Crohn's disease." Disease-a-Month 64, no. 2 (February 2018): 19. http://dx.doi.org/10.1016/j.disamonth.2017.07.002.

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28

Baumgart, Daniel C., and William J. Sandborn. "Crohn's disease." Lancet 380, no. 9853 (November 2012): 1590–605. http://dx.doi.org/10.1016/s0140-6736(12)60026-9.

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29

Wang, Ming-Hsi, and Michael F. Picco. "Crohn's Disease." Gastroenterology Clinics of North America 46, no. 3 (September 2017): 449–61. http://dx.doi.org/10.1016/j.gtc.2017.05.002.

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30

Sjödahl, Rune, and Gunnar Järnerot. "Crohn's disease." European Journal of Surgery 164, no. 12 (November 27, 2003): 883–86. http://dx.doi.org/10.1080/110241598750005020.

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31

Kalla, R., N. T. Ventham, J. Satsangi, and I. D. R. Arnott. "Crohn's disease." BMJ 349, no. 19 13 (November 19, 2014): g6670. http://dx.doi.org/10.1136/bmj.g6670.

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32

Shenker, Natalie, Ioannis Nikolopoulos, and Vanash Patel. "Crohn's Disease." Annals of The Royal College of Surgeons of England 89, no. 4 (May 2007): 446–47. http://dx.doi.org/10.1308/rcsann.2007.89.4.446.

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33

Murch, S., and J. A. Walker-Smith. "Crohn's disease." Archives of Disease in Childhood 66, no. 4 (April 1, 1991): 561. http://dx.doi.org/10.1136/adc.66.4.561-a.

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34

James, S. P., W. Strober, T. C. Quinn, and S. H. Danovitch. "Crohn's disease." Digestive Diseases and Sciences 32, no. 11 (November 1987): 1297–310. http://dx.doi.org/10.1007/bf01296381.

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35

KONO, Yoshiaki, Taketo KATSUKI, Kuniharu SAKIHAMA, Hideo YAMANARI, Hidehito NAGATOMO, Hisashi TANIKAWA, and Akira ISHIHARA. "Rectal Crohn's disease and an appendical Crohn's disease." Japanese Journal of Gastroenterological Surgery 21, no. 8 (1988): 2192–95. http://dx.doi.org/10.5833/jjgs.21.2192.

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36

Lightner, Amy L. "Challenges in Crohn's disease: Complex perianal Crohn's disease." Seminars in Colon and Rectal Surgery 31, no. 2 (June 2020): 100747. http://dx.doi.org/10.1016/j.scrs.2020.100747.

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37

Bales, Gregory T., Francis H. Straus, II, and Glenn S. Gerber. "Crohn's Disease and Urinary Bladder Mass." Diagnostic and Therapeutic Endoscopy 1, no. 4 (January 1, 1995): 233–36. http://dx.doi.org/10.1155/dte.1.233.

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The presence of a bladder mass in a patient with inflammatory bowel disease poses a diagnostic dilemma. We present the case of a 26-year-old male with a bladder mass who had not previously been diagnosed with Crohn's disease. Initial biopsies of the bladder mass were consistent with inflammatory changes, but superficial transitional cell carcinoma could not be reliably excluded. Subsequent evaluation confirmed the presence of Crohn's disease with bladder involvement, and the patient underwent bowel resection and partial cystectomy. Pathologic evaluation demonstrated Crohn’s disease and no evidence of malignancy. Accurate differentiation of benign and malignant bladder masses in patients with inflammatory bowel disease may be difficult and requires cooperation between pathologists and clinicians.
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38

Guetarni, Hassina, and Meriem Aissou. "Crohn's Disease: Retrospective Study In Algerian Patients." RADS Journal of Biological Research & Applied Sciences 13, no. 2 (December 31, 2022): 134–47. http://dx.doi.org/10.37962/jbas.v13i2.565.

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Background: Inflammatory disease of Crohn affects the entire digestive tract, with extra-intestinal manifestations and immune disorders. Objectives: This work aims to represent the histopathological aspects of Crohn‘s disease and the establishment of pathogenic bacteria as causal agents. Methodology: The histopathological aspects of the disease were studied on a colonic resection specimen and on intestinal biopsies with colorations topographic staining. Pathogenic bacteria responsible for Crohn‘s disease have also been isolated and identified. The study is continued to establish a correlation between the disease and exposure to infections by unusual bacteria, particularly pathogens (Salmonella, Shigella, Streptococcus pyogenes, Klebsiella). Results : The macroscopic appearance of the disease presented transmural involvement and can be complicated by abscesses and fistulas, microscopic appearance indicated the infiltrate of inflammatory cells (lymphocytes, plasma and cells) and lymphoid follicles after topographic staining. Crohn’s disease is an idiopathic disease, it is assumed that it is a deregulation of the immune system due to an infectious agent in genetically predisposed people. In our work, we studied the microbiota of intestine and stool of Crohn’s patients in which we found certain bacteria including Proteus mirabilis with a predominance of E. coli. Other pathogenic bacteria were found like Salmonella spp., Shigella spp., Klebsiella spp. and Streptococcus pyogenes. Two cases which tested positive on Ziehl Neelsen stain represented Mycobacterium avium paratuberculosis. Conclusion: The histopathological aspect of CD can be better visualized and identified on surgical specimens than on endoscopic biopsies, which helps to monitor the evolution of the disease and must be accompanied by clinical, serological and radiological exploration.
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39

Shadrin, O. G., V. P. Misnyk, T. L. Marushko, and R. V. Mostovenko. "Crohn’s disease in young children. Difficult path to diagnosis." Modern pediatrics. Ukraine, no. 3(131) (April 28, 2023): 111–20. http://dx.doi.org/10.15574/sp.2023.131.111.

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Inflammatory bowel diseases (IBD) is a group of chronic diseases characterized by destructive non-specific immune inflammation of the intestinal wall. The main forms include Crohn's disease and ulcerative colitis. Currently, Crohn's disease is one of the most urgent problems of children's gastroenterology, which is due to the annual increase in morbidity, "rejuvenation" of the pathological process, difficulties of diagnosis treatment, and high risk in developing of complications. IBDs with very early onset of manifestation have an atypical or erased clinical picture, which makes timely diagnosis in this age group of patients much more difficult. Purpose - to describe own clinical observation of a case of Crohn's disease with a very early onset. Clinical case. Was presented an observation of a patient of 2 years and 7 months old with Crohn’s disease the feature of which was a severe course with pronounced lesion of the gastrointestinal tract. The results of clinical data, laboratory, instrumental and histological methods of research, the complex stages of diagnosing of Crohn’s disease, as well as the issues of the patient’s treatment were discussed. The peculiarity of the described case was the early onset of the disease, continuously relapsing course, frequent acute respiratory diseases accompanied with diarrheal syndrome, absence of some specific complaints and changes in biochemical and immunological tests, corticosteroid dependence and severe extraintestinal manifestations of Crohn’s disease (anemia of a mixed nature). The diagnosis of Crohn’s disease was made at the age of 1year and 9 months (1 year and 4 months after the appearance of the first symptoms), which was confirmed a year later after a repeat examination. Late diagnosis was caused by the variety of clinical manifestations, absence of clear symptoms of the disease at the first stages of observation. The research was carried out in accordance with the principles of the Declaration of Helsinki, informed consent of the child's parents was obtained for the research. No conflict of interests was declared by the authors.
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40

Eagle, Kim, John M. Carethers, and W. Michael McDonnell. "Manifestations of Crohn's Disease -- Extraintestinal Manifestations of Crohn's Disease." New England Journal of Medicine 330, no. 26 (June 30, 1994): 1870. http://dx.doi.org/10.1056/nejm199406303302607.

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41

Yamamoto, Takayuki, Antonino Spinelli, and Paulo Gustavo Kotze. "Challenges in Crohn's disease: Crohn's disease involving the duodenum." Seminars in Colon and Rectal Surgery 31, no. 2 (June 2020): 100745. http://dx.doi.org/10.1016/j.scrs.2020.100745.

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42

Fantodji, C., M. C. Rousseau, B. Nicolau, S. Madathil, A. Benedetti, and P. Jantchou. "DOP24 Early life exposures and risk for inflammatory bowel disease: a nested case-control study in Quebec, Canada." Journal of Crohn's and Colitis 17, Supplement_1 (January 30, 2023): i88. http://dx.doi.org/10.1093/ecco-jcc/jjac190.0064.

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Abstract Background Early childhood is an important period for the establishment of gut microbiota. Most early life risks or protective factors for inflammatory bowel disease are likely to act through an effect on the gut microbiota. The aim of this study was to estimate the associations between exposures in infancy (birth until 3 years of age) such as breastfeeding, antibiotic treatment, presence of domestic pets, and passive smoking, and the occurrence of inflammatory bowel diseases. Methods This case-control study was nested within the Quebec Birth Cohort on Immunity and Health. Cases and controls were identified among persons born in Quebec in 1970-1974 based on their health services from 1983 to 2014 using validated algorithms. All cases and randomly selected controls were invited to participate in a web or telephone questionnaire. Participation rates were 47% among controls (n=946), and respectively 52% (n=1212) and 55% (n=570) among cases of Crohn’s disease and ulcerative colitis. Logistic regression models were used to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI), separately for Crohn's disease and ulcerative colitis. Each exposure was analyzed in a multiple regression model adjusted for relevant covariates identified with a directed acyclic graph. Results Adjusting for perinatal and sociodemographic characteristics, the risk for Crohn's disease or ulcerative colitis did not differ in subjects who were exclusively breastfed compared to non-breastfed subjects. Partial breastfeeding (breastfeeding combined with infant formula) was not associated with Crohn’s disease (OR=1.03, 95% CI: 0.76-1.40), but an increase in the odds of ulcerative colitis (OR=1.40, 95% CI: 0.99-1.99) was observed as compared with no breastfeeding. Early introduction of solid foods was associated with higher odds of Crohn's disease (introduction at 3-6 months compared with >6 months: OR=1.35; 95% CI: 1.05-1.78), but not of ulcerative colitis (OR=1.06; 95% CI: 0.77-1.46). Antibiotic use and the presence of domestic pets were not associated with either Crohn's disease or ulcerative colitis. Passive smoking was associated with increased odds of Crohn’s disease (OR=1.23; 95% CI: 1.00-1.51), but not ulcerative colitis (OR=0.96; 95% CI: 0.75-1.22). Conclusion Differences were noticed in early childhood risk factors for Crohn’s disease and ulcerative colitis. Early introduction of solid foods and passive smoking increased the risk of Crohn's disease, whereas there was a trend of increased risk of ulcerative colitis with partial as compared with no breastfeeding. The results for partial breastfeeding and early introduction of solid foods are novel and will require further investigation.
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43

Cohen, Zane, and Robin S. McLeod. "Perianal Crohn's Disease." Gastroenterology Clinics of North America 16, no. 1 (March 1987): 175–89. http://dx.doi.org/10.1016/s0889-8553(21)00488-x.

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44

Ford, Molly M. "Crohn's Disease Obstructions." Clinics in Colon and Rectal Surgery 34, no. 04 (July 2021): 227–32. http://dx.doi.org/10.1055/s-0041-1729926.

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AbstractObstruction from stricturing Crohn's disease remains one of the most common reasons for intervention. Acute inflammation is often responsive to medications, but chronic fibrosis is unlikely to respond and will generally go on to require additional treatment. Newer methods, such as endoscopic balloon dilation, are gaining grounds in strictures that are amenable, but with high recurrence and strictures that may not be endoscopically accessible, surgery still plays a key role in the treatment of obstructing Crohn's disease.
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45

BUCKLEY, C., A. H. M. BAYOUMI, and I. SARKANY. "Metastatic Crohn's disease." Clinical and Experimental Dermatology 15, no. 2 (March 1990): 131–33. http://dx.doi.org/10.1111/j.1365-2230.1990.tb02049.x.

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46

Sanchez, William, and Edward V. Loftus. "Fistulizing Crohn's Disease." New England Journal of Medicine 347, no. 6 (August 8, 2002): 416. http://dx.doi.org/10.1056/nejmicm010427.

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47

Present, Daniel H. "Gastroduodenal Crohn's Disease." Inflammatory Bowel Diseases 9, no. 2 (March 2003): 131. http://dx.doi.org/10.1097/00054725-200303000-00010.

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48

Kefalas, Costas H. "Gastroduodenal Crohn's Disease." Baylor University Medical Center Proceedings 16, no. 2 (April 2003): 147–51. http://dx.doi.org/10.1080/08998280.2003.11927896.

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49

Morales, Maria Susana, Mario Marini, Mirta Caminero, and Patricia Caglio. "Perianal Crohn's disease." International Journal of Dermatology 39, no. 8 (August 2000): 616–18. http://dx.doi.org/10.1046/j.1365-4362.2000.00022.x.

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50

Meurman, Jukka H. "CROHN'S DISEASE REVISITED." Journal of the American Dental Association 128, no. 6 (June 1997): 694. http://dx.doi.org/10.14219/jada.archive.1997.0277.

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