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Journal articles on the topic 'Crohn's Diseases (CD)Bloating'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Priyanka, Bhandari* Rahul Chauhan Sachin Sajwan. "Botanical Remedies for Managing Inflammatory Bowel Diseases." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3168–81. https://doi.org/10.5281/zenodo.15462569.

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Millions of people worldwide suffer from inflammatory bowel disease (IBD), a chronic inflammatory gastrointestinal disorder that includes Crohn's disease and ulcerative colitis. Although the exact cause is unknown, a complex interaction of immunological, environmental, and genetic variables is believed to be responsible. The incidence of IBD has increased over the past century, especially in industrialized countries, most likely as a result of environmental factors such as food, antibiotic usage, and urbanization that cause imbalances in the gut microbiota. Stress and smoking are also recogniz

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Starz, Eliza, Karolina Wzorek, Marcin Folwarski, et al. "The Modification of the Gut Microbiota via Selected Specific Diets in Patients with Crohn’s Disease." Nutrients 13, no. 7 (2021): 2125. http://dx.doi.org/10.3390/nu13072125.

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Gastrointestinal symptoms in Crohn’s disease (CD) are common and affect the quality of life of patients; consequently, a growing number of studies have been published on diet interventions in this group. The role of the gut microbiota in the pathogenesis and the progression of inflammatory bowel diseases (IBD), including CD, has been widely discussed. Mainly, a decreased abundance of Firmicutes, species of the Bifidobacterium genus, and the Faecalibacterium prausnitzii species as well as a reduced general diversity have been described. In this review article, we summarize available data on the

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Kulygin, Yu A., and M. F. Osipenko. "Excessive bacterial growth syndrome in small intestine burdens the clinical picture of inflammatory bowel diseases." Experimental and Clinical Gastroenterology, no. 4 (July 26, 2023): 49–54. http://dx.doi.org/10.31146/1682-8658-ecg-212-4-49-54.

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Research objective: to study the frequency of small intestinal bacterial overgrowth (SIBO) and factors associated with it in patients with inflammatory bowel diseases (IBD). Materials and methods of the study: 152 patients with IBD (Crohn’s disease and ulcerative colitis) a hydrogen breathing test (HBT) with lactulose, performed by the “Gastro+” monitor using lactulose. In all patients, the characteristics of the course of IBD were evaluated, including 60 parameters: the time of diagnosis of IBD, the existing symptoms assessed by a visually analog scale (VAS), extra-intestinal manifestations,

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Vinni, E., K. Karaivazoglou, T. Lourida, et al. "P194 Alexithymia traits are associated with symptom severity and disease activity in IBD patients." Journal of Crohn's and Colitis 15, Supplement_1 (2021): S260. http://dx.doi.org/10.1093/ecco-jcc/jjab076.320.

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Abstract Background Alexithymic traits are quite prevalent in patients with inflammatory bowel diseases (IBD) and have been linked with a heightened psychological burden including anxiety, depression, somatization and obsessive-compulsive symptoms. However, there are limited data regarding the association of alexithymia with gastrointestinal symptom severity and disease activity. Methods The current study was conducted at the Division of Gastroenterology of the University Hospital of Patras, in Greece with the collaboration of the Department of Psychiatry. Adult IBD outpatients and healthy con

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Saunders, B., K. Lesack, R. Rosentreter, et al. "P771 Comparing obstructive symptoms and dietary restrictions with Crohn's disease stricture severity." Journal of Crohn's and Colitis 18, Supplement_1 (2024): i1439. http://dx.doi.org/10.1093/ecco-jcc/jjad212.0901.

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Abstract Background Stricturing Crohn’s Disease (CD) is characterized by bowel narrowing often leading to obstruction. Obstructive symptoms (OS) have been evaluated in patients with CD strictures using OS scores (STRIDENT). Clinical observations suggest that OS are generally associated with end-stage strictures requiring dietary restrictions and surgery. Evaluating the prevalence of symptoms in strictures is important as regulatory agencies require symptom response to therapies in trials. Intestinal ultrasound (IUS) accurately assesses CD strictures. IUS criteria for ileal strictures includes:

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Boscarelli, Alessandro, and Matteo Bramuzzo. "Pediatric stricturing Crohn's disease." World Journal of Gastroenterology 30, no. 12 (2024): 1651–54. http://dx.doi.org/10.3748/wjg.v30.i12.1651.

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Crohn’s disease (CD) is a chronic inflammatory disease of the digestive tract. The incidence of pediatric CD is increasing and is currently 2.5–11.4 per 100000 world-wide. Notably, approximately 25% of children with CD develop stricturing CD (SCD) that requires intervention. Symptomatic stricturing diseases refractory to pharmacological management frequently require non-pharmacological interventions. Non-pharmacological therapeutic strategies include endoscopic balloon dilatation, stricturoplasty, and surgical resection of the strictured segment. However, strictures tend to recur postoperative

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Khalaf, Asseel, Caroline L. Hoad, Alex Menys, et al. "Gastrointestinal peptides and small-bowel hypomotility are possible causes for fasting and postprandial symptoms in active Crohn's disease." American Journal of Clinical Nutrition 111, no. 1 (2019): 131–40. http://dx.doi.org/10.1093/ajcn/nqz240.

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ABSTRACT Background Crohn's disease (CD) patients suffer postprandial aversive symptoms, which can lead to anorexia and malnutrition. Changes in the regulation of gut hormones and gut dysmotility are believed to play a role. Objectives This study aimed to investigate small-bowel motility and gut peptide responses to a standard test meal in CD by using MRI. Methods We studied 15 CD patients with active disease (age 36 ± 3 y; BMI 26 ± 1 kg/m 2) and 20 healthy volunteers (HVs; age 31 ± 3 years; BMI 24 ± 1 kg/m 2). They underwent baseline and postprandial MRI scans, symptom questionnaires, and blo

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Evers, Charles D., Aishwarya Ravindran, Frida Rosenblum, and Frederick Weber. "A Pelvic Mass in a Young Patient With Crohn's Disease." ACG Case Reports Journal 12, no. 3 (2025): e01627. https://doi.org/10.14309/crj.0000000000001627.

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ABSTRACT Castleman disease (CD) is a rare group of lymphoproliferative disorders subdivided based on clinical features. Although not fully understood, the pathogenesis of both CD and Crohn's disease involves a combination of immune dysregulation and infectious and environmental factors. Interleukin-6, a proinflammatory cytokine, is associated with both diseases and can serve as a common therapeutic target in CD. We report a rare case of coexisting unicentric Castleman disease in a young patient with Crohn's disease.

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Herfarth, Hans H. "Methotrexate for Inflammatory Bowel Diseases - New Developments." Digestive Diseases 34, no. 1-2 (2016): 140–46. http://dx.doi.org/10.1159/000443129.

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Methotrexate (MTX) is an established therapy for patients with steroid-dependent Crohn's disease (CD). MTX is also frequently used in combination with anti-TNF agents to suppress anti-drug antibody formation. It has been suggested in the past that MTX lacks any clinical effectiveness in patients with ulcerative colitis (UC); however, newer data at least partially contradict this assumption. The following review will discuss recent data for the use of MTX in CD, UC and in combination with anti-TNF agents.

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ZHARGALOVA, G. M., and P. V. SELIVERSTOV. "DIAGNOSTIC IMAGING IN CROHN'S DISEASE." AVICENNA BULLETIN 27, no. 2 (2025): 441–52. https://doi.org/10.25005/2074-0581-2025-27-2-441-452.

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Crohn's disease (CD) is an inflammatory bowel disease with an unknown etiology, and many authors suggest that its prevalence is steadily increasing worldwide. Among the various diagnostic methods available, ileocolonoscopy with biopsy is considered the "gold standard" for detecting intestinal diseases. However, since CD can affect any part of the gastrointestinal tract, this method has limitations. It cannot examine the proximal parts of the small intestine or evaluate all layers of the intestinal wall. Furthermore, this invasive procedure is often poorly tolerated by patients, making it less

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Uspensky, Yu P., Yu A. Fominykh, and A. A. Gnutov. "Oral lesions in Crohn's disease (clinical case)." Medical alphabet, no. 34 (January 18, 2024): 20–23. http://dx.doi.org/10.33667/2078-5631-2023-34-20-23.

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Crohn's disease is a chronic inflammatory bowel disease that can affect any part of the digestive tract from the mouth to the anus. Oral lesions in oral Crohn's disease are the most common extraintestinal manifestations of this disease and may reflect various pathogenic diseases. They can cause specific granulomatous inflammation in the oral mucosa, may be caused by malabsorption in patients, and also with side effects of CD drug therapy. In CD, several extraintestinal manifestations can also occur at the same time, and the appearance of one of them increases the likelihood of developing anoth

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Zhang, Shi-Yan, and Yin Lin. "Addressing diagnostic delays in inflammatory bowel diseases in Germany." World Journal of Gastroenterology 30, no. 41 (2024): 4484–89. http://dx.doi.org/10.3748/wjg.v30.i41.4484.

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Inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis, are chronic inflammatory conditions of the gastrointestinal tract that necessitate timely diagnosis to prevent complications and improve patient outcomes. Despite advancements in medical knowledge and diagnostic techniques, significant diagnostic delays persist, particularly in CD. The study by Blüthner et al , published in the World Journal of Gastroenterology , elucidates the diagnostic delays experienced by German patients with IBD and identifies key risk factors contributing to these delays.

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Cauchi, M., D. P. Fowler, C. Walton, et al. "Comparison of GC-MS, HPLC-MS and SIFT-MS in conjunction with multivariate classification for the diagnosis of Crohn's disease in urine." Analytical Methods 7, no. 19 (2015): 8379–85. http://dx.doi.org/10.1039/c5ay01322d.

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KOZALAK, Gül, Nazente ATCEKEN, and Rıza Köksal OZGUL. "IDENTIFICATION OF HUB GENES AND KEY PATHWAYS BETWEEN CELIAC AND CROHN'S DISEASES VIA BIOINFORMATICS TOOLS." Periódico Tchê Química 19, no. 41 (2022): 35–47. http://dx.doi.org/10.52571/ptq.v19.n41.2022.04_gul_pgs_35_47.pdf.

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Background: Chronic inflammatory diseases are the long-term response of the organism to any stimulus. Crohn's (CD) and Celiac (CeD) diseases are among chronic inflammatory diseases, and both cause chronic inflammation in the intestines. Both diseases are caused by polygenic, environmental, and lifestyle risk factors. Inflammation can perpetuate disease and cause it to become chronic. For this reason, CD and CeD that choose the intestine as the target organ may trigger each other. Although the relationship between these diseases is widely mentioned in the literature, scanty knowledge and resear

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Ruchkina, Irina N., Oleg V. Knyazev, Alina A. Kieva, et al. "Combination of Crohn's disease and intestinal tuberculosis. Clinical observation." Terapevticheskii arkhiv 96, no. 12 (2024): 1245–52. https://doi.org/10.26442/00403660.2024.12.203115.

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According to WHO, extrapulmonary forms of tuberculosis (TB) account for 10–15% of the total number of tuberculosis cases worldwide. Crohn's disease (CD) and intestinal tuberculosis have similar clinical, endoscopic and morphological manifestations in many ways. In all cases, when detecting intestinal CD, it is necessary to exclude tuberculosis infection in biopsies using PCR diagnostics. The risk of developing various forms of TB increases with pathogenetic immunosuppressive therapy for inflammatory bowel diseases. A clinical case of a rare combination of the intestinal form of TB and CD is pr

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Lourenço, Lourdes da Cruz Balta, Ana Sofia Barroso Frattini Ramos, Larissa Lorraine Meiado Bochini, et al. "CROHN'S DISEASE AND OSTEOPOROSIS: RISK FACTORS, DIAGNOSIS AND CLINICAL TREATMENT." Brazilian Journal of Implantology and Health Sciences 6, no. 8 (2024): 1133–45. http://dx.doi.org/10.36557/2674-8169.2024v6n8p1133-1145.

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Crohn's disease (CD) is a chronic inflammatory bowel disease that affects any part of the gastrointestinal tract. Osteoporosis, in turn, is a skeletal disease characterized by decreased bone mass and deterioration of bone microarchitecture, increasing the risk of fractures. The association between these two diseases has been increasingly investigated, with evidence suggesting that patients with CD are at increased risk of developing osteoporosis. This comorbidity can be attributed to several factors, including corticosteroid use, nutrient malabsorption, chronic inflammation, and hormonal dysfu

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Fayadh Sameer, Adnan, Abed Hassan Barraj, and Hayder Jamaal Mahmood. "NOD1/CARD4(G796A) and NOD2/CARD15(R702W, G908R and L1007fsinC) polymorphisms associated with Crohn's disease in Iraqi patients." Bionatura 7, no. 3 (2022): 1–8. http://dx.doi.org/10.21931/rb/2022.07.03.38.

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Inflammatory bowel disease (IBD) applies to two main forms of chronic relapsing inflammatory intestinal disorders: Crohn's disease (CD), Ulcerative colitis (UC). CD requires an irregular immune reaction that induces intense inflammation. The cause of CD disease is not yet fully known; previous research, however, indicated inflammation of the intestines elevated or continues due to inappropriate immune responses due to associations between genetic factors, intestinal microbiota, and environmental factors contributing to the production of IBD. This study aimed to investigate predisposing genes,

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Ma, Yimin, Duanming Zhuang, and Zhenguo Qiao. "Dual threat of comorbidity of celiac disease and systemic lupus erythematosus." Journal of International Medical Research 49, no. 5 (2021): 030006052110122. http://dx.doi.org/10.1177/03000605211012258.

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Celiac disease (CD) is a chronic immune-mediated intestinal disease that is characterized by production of autoantibodies directed against the small intestine. The main clinical manifestations of CD are typically defined as those related to indigestion and malabsorption. These manifestations include unexplained diarrhea or constipation, abdominal pain, bloating, weight loss, anemia, failure-to-thrive in children, and decreased bone density. Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by heterogeneous clinical manifestations, which may also involve the gastrointest

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Alves, Marcos Gondim Rocha, Ivana Freitas Afonso, Arianne Louise Campelo Naia de Araujo, et al. "Crohn's Disease: advantages of the Konos-S surgical technique." Research, Society and Development 11, no. 6 (2022): e7911628803. http://dx.doi.org/10.33448/rsd-v11i6.28803.

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Introduction: Crohn's Disease (CD) belongs to the group of diseases called Inflammatory Bowel Diseases (IBD). CD is an inflammatory disease characterized by idiopathic, local and chronic nonspecific inflammation, currently the real cause is still unknown. The recurrence of anastomosis after intestinal resection is one of the most significant problems in the management of CD, recently a new surgical technique was described and used to reduce recurrence, the Konos-S technique described by Konos et al. (2011). Objective: To carry out a systematic review of the literature to describe Crohn's disea

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Dragašević, Sanja, Milica Stojković-Lalošević, Andreja Nikolić, Nikola Panić, and Vladimir Milivojević. "Is fecal calprotectin a dependable indicator of activity in inflammatory bowel diseases?" Medicinska istrazivanja 56, no. 4 (2023): 35–40. http://dx.doi.org/10.5937/medi56-46194.

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Introduction/Aim: Fecal calprotectin (FCP) is an S100 protein bio-marker used in diagnostic and monitoring algorithms of inflammato-ry bowel diseases (IBD). The role of FCP is established in differentiating inflammatory from functional bowel diseases, predicting relapse of IBD, and monitoring response to IBD therapy. The therapeutic strategy "treat-to-target" includes the normalization of laboratory biomarkers including FCP to attain mucosal healing (MH) as a result of effective Crohn's disease (CD) and ulcerative colitis (UC) treatment. Our research aimed to assess the relationship of FCP val

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Alekseeva, A. A., O. P. Alekseeva, and S. V. Krishtopenko. "Constructing the function of prednisone efficacy for the treatment of inflammatory bowel diseases based on a clinical model." Clinical pharmacology and therapy 33, no. 2 (2022): 32–36. http://dx.doi.org/10.32756/0869-5490-2022-2-32-36.

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Kafe, Fadhela Nafaa, Essam Mohammed Abdullah, and Issam Abdulkriam Selman. "Study the Association of IL-18 on Crohn'S Disease in Iraq Population." Journal of Pioneering Medical Science 12, no. 4 (2023): 21–24. http://dx.doi.org/10.61091/jpms20231245.

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Crohn's disease (CD) is an inflammatory bowel illness that can affect any portion of the GI tract, including the colon. The CD is caused by an abnormal immune response to microbiota in the gastrointestinal system, and it can develop in those genetically predisposed to it. Inflammatory bowel disease, on the other hand, is well-acknowledged to be a complex condition in which intrinsic genetic factors may play a role. Cytokine genes are thought to be crucial in inflammatory bowel disease. Interleukin 18, a newly discovered proinflammatory cytokine, has lately been related to CD and other inflamma

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Majsiak, Emilia, Magdalena Choina, Alastair M. Gray, Mariusz Wysokiński, and Bożena Cukrowska. "Clinical Manifestation and Diagnostic Process of Celiac Disease in Poland—Comparison of Pediatric and Adult Patients in Retrospective Study." Nutrients 14, no. 3 (2022): 491. http://dx.doi.org/10.3390/nu14030491.

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The diagnosis of celiac disease (CD) may be delayed due to non-specific clinical symptoms. The aim of the study was to evaluate the clinical manifestation and diagnostic process of CD in Polish children and adults. Methods: The members of the Polish Coeliac Society (n = 2500) were asked to complete a questionnaire on socio-demographic factors, clinical and diagnostic aspects of CD. The analysis was based on 796 responses from patients with confirmed CD diagnosis, and included 224 (28.1%) children and 572 (71.9%) adults. Results: The mean duration of symptoms prior to CD diagnosis in children w

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Fayadh Sameer, Adnan. "Investigation of Crohn's Disease by Immunohistochemistry Technique in Iraqi Patients." Bionatura 8, no. 2 (2023): 1–12. http://dx.doi.org/10.21931/10.2931/rb/2023.08.02.2.

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Crohn's disease (CD) is one of the most common IBD types. CD necessitates an erratic immune response. Previous research has shown that inflammation of the intestines is elevated or continues due to inappropriate immune responses that result from the relationships between environmental factors, intestinal microbiota, and genetic factors. Induces intense transmural inflammation. This study aimed to investigate (i) CD detection by Histopathology and Immunohistochemistry (IHC) Markers that are Mycobacterium avium subspecies paratuberculosis MAP antibody and TWEAK/Fn14 antibody and their associatio

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Zabot, Gilmara Pandolfo, Maria Gabriela Perera, Cíntia Ribeiro Pinheiro, et al. "Clinical Profile of Patients with Inflammatory Bowel Diseases in a Private Service." Journal of Coloproctology 44, no. 03 (2024): e151-e155. http://dx.doi.org/10.1055/s-0044-1789195.

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AbstractInflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory conditions affecting the digestive tract. This study examines 188 IBD patients in a private healthcare service in Canoas/RS, Brazil, aiming to understand their clinical profiles.Most patients were young adults, primarily white, with more women affected. Both CD and UC patients commonly experienced diarrhea, but blood in stools was more prevalent in UC. CD mostly affected the small intestine, while UC involved the rectum or extended through the colon. The diagnosis was

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Thaver, Danyal, and Mirza Beg. "Pulmonary Crohn's Disease in Down Syndrome: A Link or Linkage Problem." Case Reports in Gastroenterology 10, no. 2 (2016): 206–11. http://dx.doi.org/10.1159/000445975.

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Crohn’s disease (CD) is an autoimmune inflammatory disorder that primarily affects the gastrointestinal tract. It may have pulmonary involvement, which has been rarely reported in pediatric patients. Down syndrome (DS) has been associated with increased frequency of autoimmune diseases. However, associations between CD and DS have been rarely reported. We present the case of a 5-year-old girl with known DS and a history of chronic intermittent abdominal pain who presented with persistent pneumonia. Her workup included a chest computed tomography (CT) scan that showed multiple noncalcified pulm

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Chaimae, Abdouh, Salihoun Mouna, Serraj Ilham, Acharki Mohamed, and Kabbaj Nawal. "Indications and Results of Endoanal Ultrasonography in Anal Pathology." Saudi Journal of Medical and Pharmaceutical Sciences 9, no. 07 (2023): 501–4. http://dx.doi.org/10.36348/sjmps.2023.v09i07.021.

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Anal disease encompasses a diverse array of disorders, including conditions such as sphincter defects, anorectal fistulas and abscesses, unexplained chronic anal pain. The objective of this study is to assess the diagnostic value of endoscopic ultrasound (EUS) in the context of anal diseases. A total of 58 patients who benefited from an EUS, over a period between January 2018 and april 2023. Mean age was 43,4 years with a sex ratio (M: F) of 0.4. The main indication for EUS is dominated by fecal incontinence (FI) in 53% of patients, followed by the anoperineal manifestations of Crohn's disease

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Subramanian, Sreedhar, Carol L. Roberts, C. Anthony Hart, et al. "Replication of Colonic Crohn's Disease Mucosal Escherichia coli Isolates within Macrophages and Their Susceptibility to Antibiotics." Antimicrobial Agents and Chemotherapy 52, no. 2 (2007): 427–34. http://dx.doi.org/10.1128/aac.00375-07.

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ABSTRACT There is increasing evidence that Escherichia coli organisms are important in Crohn's disease (CD) pathogenesis. In CD tissue they are found within macrophages, and the adherent-invasive CD ileal E. coli isolate LF82 can replicate inside macrophage phagolysosomes. This study investigates replication and antibiotic susceptibility of CD colonic E. coli isolates inside macrophages. Replication of CD colonic E. coli within J774-A1 murine macrophages and human monocyte-derived macrophages (HMDM) was assessed by culture and lysis after gentamicin killing of noninternalized bacteria and veri

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Yunusova, R. D., I. N. Usmanova, I. A. Lakman, A. N. Ishmukhametova, A. P. Akopyan, and E. A. Gaisina. "Correlation between dental symptoms and functional and clinical manifestations of Crohn's disease and ulcerative colitis." Perm Medical Journal 41, no. 4 (2024): 5–15. http://dx.doi.org/10.17816/pmj4145-15.

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Objective. To analyze the correlation between dental symptoms and clinical and functional manifestations of Crohn's disease (CD) and ulcerative colitis (UC). Materials and methods. A prospective, observational, longitudinal clinical study of 70 patients with verified inflammatory bowel diseases, i.e. Crohn's disease and ulcerative colitis, has been performed. For an in-depth assessment of the oral mucosa (OM) and red lip border (RLB) condition in patients with these systemic diseases, a complete dental examination has been carried out. The validated questionnaire "7´7" was used to objectify th

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Flores, C., R. K. Souza, L. R. De Bona, et al. "P213 High prevalence and risk factors for nonalcoholic fatty liver disease in patients with Crohn's disease." Journal of Crohn's and Colitis 17, Supplement_1 (2023): i364—i365. http://dx.doi.org/10.1093/ecco-jcc/jjac190.0343.

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Abstract Background Prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) is increasing in patients with Inflammatory Bowel Disease (IBD), particularly Crohn's Disease (CD). Despite this, the mechanisms and risk factors of NAFLD in IBD are still poorly understood and controversial. The aim of this study was to assess the prevalence and risk factors for NAFLD in patients with CD. Methods Prospective study conducted among consecutive patients with CD and treated at the Inflammatory Bowel Diseases outpatient clinic at University Hospital between July 2021 and May 2022. Demographic, anthropometr

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Dionne, Serge, Carl-Frederic Duchatelier, and Ernest G. Seidman. "The influence of vitamin D on M1 and M2 macrophages in patients with Crohn's disease." Innate Immunity 23, no. 6 (2017): 557–65. http://dx.doi.org/10.1177/1753425917721965.

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Defective bacterial clearance by macrophages plays an important role in Crohn’s disease (CD). Phenotypes and functions of inflammatory M1 and anti-inflammatory M2 have not been studied in CD. Vitamin D supplementation reduces the severity of CD by unclear mechanisms. We studied macrophage characteristics in CD and controls and the effects of 1,25 vitamin D (1,25D). PBMC were isolated from CD patients and controls. M1 and M2 were generated by culturing of monocytes with GM-CSF and M-CSF, respectively. CD M1 and M2 showed normal phagocytosis and chemotaxis to CCL2 and fMLP. LPS-induced productio

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Kiliç, V., F. Kivrakoglu, M. Ergin, H. Kucuk, and I. Yuksel. "P302 Diagnostic Delayed is Associated with a Poor Prognosis in Patients with Crohn's Disease." Journal of Crohn's and Colitis 18, Supplement_1 (2024): i678. http://dx.doi.org/10.1093/ecco-jcc/jjad212.0432.

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Abstract Background The studies show that diagnostic delay, especially in Crohn’s disease (CD), is associated with a higher risk of complications and major surgery. We aimed to investigate timing of the diagnostic delay (DD) and its impact on the CD outcomes. Methods We retrospectively evaluated demographic and clinical features of CD patients between June 1993 and October 2023. Diagnostic delay was defined as the time interval from the onset of the first symptoms to the making of the CD diagnosis. The first CD related symptoms were evaluated by a review of the physician’s notes and medical re

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Abdulganieva, D. I., A. L. Bakulev, E. А. Belousova, et al. "Draft interdisciplinary guidelines for diagnosis, methods for estimation of the degree of activity, for evaluation of therapeutic efficacy, and for use of biological agents in patients with concomitant immunoinflammatory diseases (psoriasis, psoriatic arthritis, Crohn's disease)." Modern Rheumatology Journal 12, no. 3 (2018): 4–18. http://dx.doi.org/10.14412/1996-7012-2018-3-4-18.

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Due to that one patient may be at high risk for developing several immunoinflammatory diseases (psoriasis, psoriatic arthritis (PsA), and Crohn's disease (CD)), their early diagnosis and adequate therapy are extremely relevant. The Interdisciplinary Working Group that includes experts in rheumatology, gastroenterology and dermatology has developed draft guidelines for early diagnosis, methods for activity assessments and for indications for the use of biological agents in patients with concomitant immunoinflammatory diseases (psoriasis, PsA, and CD). In accordance with the decision adopted by

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Kamalova, Aelita A., Marina A. Khanafina, and Galina A. Garina. "Clinical and Diagnostic Value of Inflammatory Bowel Diseases' Serological Markers in Children (Literature Review)." Pediatric pharmacology 20, no. 4 (2023): 309–17. http://dx.doi.org/10.15690/pf.v20i4.2605.

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The prevalence of inflammatory bowel diseases (IBD) is increasing worldwide. Crohn's disease (CD) and ulcerative colitis (UC) are characterized by chronic progressive course, high frequency of complications, and high risk of surgical treatment. Up to 50% of CD patients die due to its complications, and quarter of these patients require at least one surgery during their lifetime. IBD patients have 8 times higher risk of colorectal and small intestine cancer. IBD diagnosis can be established during childhood in 25% of cases. Early intensified therapy of individual patient groups could significan

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Semikina, E. L., V. S. Tsvetkova, A. S. Potapov, et al. "Diagnostic value of platelet count and platelet indices in assessing inflammatory bowel disease activity in children." Voprosy detskoj dietologii 19, no. 3 (2021): 26–36. http://dx.doi.org/10.20953/1727-5784-2021-3-26-36.

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Objective. To analyze the connection between the complex of platelet indices in complete blood count test with the clinical and endoscopic activity scores for Crohn's disease (CD) and ulcerative colitis (UC) in pediatric patients and to determine their most informative threshold values. Patients and methods. In this study, 370 children aged 5 to 18 years with diagnosed CD (n = 150) and UC (n = 220) were examined. The clinical activity of UC was assessed according to PUCAI, CD – according to PCDAI; the assessment of endoscopic activity in children with UC was carried out according to UCEIS and

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Akhrieva, Kh M., A. S. Tertychnyy, N. V. Pachuashvili, and N. S. Marenich. "Atypical «overlapping» variants of inflammatory bowel diseases." Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH) 14, no. 4 (2024): 6–13. http://dx.doi.org/10.20340/vmi-rvz.2024.4.morph.1.

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Objective: to analyze the challenges associated with the morphological interpretation of histological specimens that simultaneously exhibit characteristic histological features of both ulcerative colitis (UC) with features of Crohn's disease (CD), and CD with features resembling UC (so-called " overlapping " forms).Object and methods. Between 2019 and 2024, UC was diagnosed in 180 patients and CD in 120 patients. The average age of the patients was 48 ± 6 years. Diagnoses were established based on a combination of clinical-laboratory, endoscopic, and morphological data. A search was conducted

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Alekseieva, Y., O. Synoverska, Z. Vovk, T. Berezna, and V. Voloshynovych. "DESCRIPTION OF A CLINICAL CASE OF CROHN'S DISEASE IN A CHILD WITH ATYPICAL DISEASE MANIFESTATION." Neonatology, Surgery and Perinatal Medicine 15, no. 2(56) (2025): 224–28. https://doi.org/10.24061/2413-4260.xv.2.56.2025.32.

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The global incidence of chronic bowel diseases in pediatric patients is steadily increasing, with ulcerative colitis and Crohn’s disease (CD) representing the most severe forms. Inflammatory bowel diseases in children are characterized by higher disease activity, a greater frequency of complications, involvement of extraintestinal organs and systems in the pathological process, and reduced responsiveness to therapy. These conditions adversely affect the child’s growth and development, leading to malnutrition, impaired psychosocial functioning, and diminished adaptive capacity in both physical

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Jakubowska, Katarzyna, I. Backiel, L. Kańczuga-Koda, K. Bobel, S. Sulkowski, and M. Koda. "Infiltration of CD138-positive plasma cells in endoscopic material from patients with inflammatory bowel diseases." Progress in Health Sciences 14, no. 2 (2024): 53–61. https://doi.org/10.5604/01.3001.0054.9112.

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Introduction: CD138 (syndecan-1) expression hasbeen confirmed in plasma cells and normal tissues,particularly in epithelial cell types. As a cell surfaceprotein, CD138 regulates cell-cell and cell-matrixinteractions. CD138 may also regulate cellproliferation, migration, and cytoskeletal organiza-tion. In addition, positive CD138 plasma cells canalso be detected with extreme infiltration ininflammatory diseases such as chronic endometritis.Purpose: Investigation of the prognosticsignificance of the infiltration of CD 138 plasmacells in endoscopic material from patients withulcerative colitis (U

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Bourgonje, A. R., N. V. Hörstke, M. Fehringer, G. Innocenti, and T. Vogl. "DOP27 Systemic antibody responses against gut microbiota flagellins implicate shared and divergent immune reactivity in Crohn's Disease and chronic fatigue syndrome." Journal of Crohn's and Colitis 18, Supplement_1 (2024): i122. http://dx.doi.org/10.1093/ecco-jcc/jjad212.0067.

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Abstract Background Patients with Crohn’s disease (CD) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) exhibit elevated antibody responses against gut microbiota flagellins. However, flagellin-specific antibody repertoires and functional roles in the diseases remain incompletely understood. Bacterial flagellins can be categorized into three types depending on their interaction with toll-like receptor 5 (TLR5): (1) "stimulator" and (2) "silent" flagellins, binding TLR5 through a conserved N-terminal motif, with only stimulators activating TLR5 due to a specific C-terminal domain

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Wei, Bo, Tiffany Huang, Harnisha Dalwadi, Christopher L. Sutton, David Bruckner, and Jonathan Braun. "Pseudomonas fluorescens Encodes the Crohn's Disease-Associated I2 Sequence and T-Cell Superantigen." Infection and Immunity 70, no. 12 (2002): 6567–75. http://dx.doi.org/10.1128/iai.70.12.6567-6575.2002.

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ABSTRACT Commensal bacteria have emerged as an important disease factor in human Crohn's disease (CD) and murine inflammatory bowel disease (IBD) models. We recently isolated I2, a novel gene segment of microbial origin that is associated with human CD and that encodes a T-cell superantigen. To identify the I2 microorganism, BLAST analysis was used to identify a microbial homologue, PA2885, a novel open reading frame (ORF) in the Pseudomonas aeruginosa genome. PCR and Southern analysis identified Pseudomonas fluorescens as the originating species of I2, with homologues detectable in 3 of 13 ot

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Danilova, N. A., S. R. Abdulkhakov, T. V. Grigoryeva, et al. "Markers of dysbiosis in patients with ulcerative colitis and Crohn's disease." Terapevticheskii arkhiv 91, no. 4 (2019): 13–20. http://dx.doi.org/10.26442/00403660.2019.04.000211.

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The results of recent studies indicate a significant role of gut microbiota in the pathogenesis of inflammatory bowel diseases (IBD). The aim of the study was to study the taxonomic and functional composition of the gut microbiota in ulcerative colitis (UC) and Crohn's disease (CD) patients to identify key markers of dysbiosis in IBD. Materials and methods. Fecal samples obtained from 95 IBD patients (78 UC and 17 CD) as well as 96 healthy volunteers were used for whole-genome sequencing carried out on the SOLiD 5500 W platform. Taxonomic profiling was performed by aligning the reeds, not mape

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Muslim, Saniya, and Meenu Bagarhatta. "Intestinal Tuberculosis versus Crohn's Disease: Evaluating the Role of Computed Tomography Enterography in Differentiating the Two." Journal of Gastrointestinal and Abdominal Radiology 02, no. 02 (2019): 116–25. http://dx.doi.org/10.1055/s-0039-1691847.

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AbstractIntestinal tuberculosis (ITB) and Crohn's disease (CD) are chronic inflammatory bowel disorders that are frequently misdiagnosed due to overlapping clinical, radiologic, endoscopic, and histologic resemblance. Recent trends indicate a change in the epidemiology of inflammatory bowel diseases, with previously low-incidence areas now reporting a continuous rise in incidence. The rising incidence of CD in countries such as India where TB continues to be endemic has made the differentiation of these two disorders a diagnostic challenge. Misdiagnosis leads to delays in initiating effective

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Gondim, Francisco de Assis Aquino, Gisele Ramos de Oliveira, Benedito Cadorno V. Teles, Marcellus H. L. P. Souza, Lucia L. B. C. Braga, and Erick L. Messias. "A Case-Control study of the prevalence of neurological diseases in inflammatory bowel disease (IBD)." Arquivos de Neuro-Psiquiatria 73, no. 2 (2015): 119–24. http://dx.doi.org/10.1590/0004-282x20140223.

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Neurological diseases are common in inflammatory bowel disease (IBD) patients, but their exact prevalence is unknown. Method We prospectively evaluated the presence of neurological disorders in 121 patients with IBD [51 with Crohn's disease (CD) and 70 with ulcerative colitis (UC)] and 50 controls (gastritis and dyspepsia) over 3 years. Results Our standard neurological evaluation (that included electrodiagnostic testing) revealed that CD patients were 7.4 times more likely to develop large-fiber neuropathy than controls (p = 0.045), 7.1 times more likely to develop any type of neuromuscular c

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Komine-Aizawa, Shihoko, Hideki Masuda, Takerou Mazaki, Motomi Shiono, Satoshi Hayakawa, and Tadatoshi Takayama. "Plasma Osteopontin Predicts Inflammatory Bowel Disease Activities." International Surgery 100, no. 1 (2015): 38–43. http://dx.doi.org/10.9738/intsurg-d-13-00160.1.

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Abstract A glycoprotein osteopontin (OPN) is involved in inflammatory diseases, but its roles in inflammatory bowel disease (IBD) are controversial. To analyze the involvement of the systemic immune response, we simultaneously examined plasma OPN levels and 17 cytokines. This study included 24 ulcerative colitis (UC) patients, 17 Crohn's disease (CD) patients, and 23 normal controls. Clinical parameters were also examined. The plasma OPN levels of the UC and CD patients were significantly higher than those of the normal controls and correlated significantly with their clinical activity indices

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Ibraheem, Zahraa F., and Hanan Y. Muhsin. "Roles of Il-36 in the Pathogenesis of Inflammatory Bowel Disease in a Sample of Iraqi Patients." Pakistan Journal of Medical and Health Sciences 16, no. 6 (2022): 548–51. http://dx.doi.org/10.53350/pjmhs22166548.

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Background: IBD (Inflammatory bowel disease) is a chronic inflammatory condition that affects the intestines., in which cytokines are thought to have a role in the etiology and pathophysiology. IBD is divided into two types: Ulcerative Colitis (UC), and Crohn's Disease (CD). Aim of the study: The current study examined the level of, IL-36 in the blood of sixty IBD Iraqi patients (30 CD, 30 UC, and 30 HC). The concentrations were correlated with Age, age at onset, body mass index (BMI), cigarette-smoking status, disease duration, gender, symptoms, and extra-intestinal features. Result: The find

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Carvalho, Isabel Azevedo, David Germano Gonçalves Schwarz, Pricila Aparecida Grasse Pietralonga, et al. "Presence of Mycobacterium avium subsp. paratuberculosis (MAP) in Brazilian patients with inflammatory bowel diseases and in controls." Sao Paulo Medical Journal 134, no. 1 (2015): 13–19. http://dx.doi.org/10.1590/1516-3180.2014.8251809.

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CONTEXT AND OBJECTIVE: Mycobacterium avium subsp. paratuberculosis (MAP) has attracted the interest of researchers because of similarities between paratuberculosis and Crohn's disease (CD). The aim of this study was to evaluate the frequency of MAP through cultures, histology and polymerase chain reaction (PCR) on intestinal biopsies from Brazilian CD patients. Quantitative real time PCR (qRT-PCR) was performed on positive samples. DESIGN AND SETTING: Analytical cross-sectional study with control group at two federal universities. METHODS: Fresh samples were collected from 25 patients; five wi

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Bakhodirovna, Salimova Nigora. "THE PATHOPHYSIOLOGY OF ULCERATIVE COLITIS. THE CURRENT STATE OF THE PROBLEM OF ETIOLOGY, EARLY DIAGNOSIS AND TREATMENT." European Journal of Contemporary Business Law & Technology: Cyber Law, Blockchain, and Legal Innovations 1, no. 8 (2024): 73–78. https://doi.org/10.61796/ejcblt.v1i8.946.

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General Background: Ulcerative colitis (UC) and Crohn's disease (CD) are chronic inflammatory bowel diseases that significantly impact patients' quality of life and present substantial healthcare challenges globally. Specific Background: This review provides a comprehensive analysis of contemporary literature regarding the etiology, pathophysiology, diagnosis, and treatment of UC and CD. It highlights the prevalence of these conditions both worldwide and specifically in Uzbekistan, emphasizing their clinical significance. Knowledge Gap: Despite advancements in understanding these diseases, cha

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Будзинская, А. А., Е. А. Белоусова, С. Г. Терещенко, and А. В. Левитская. "ULCERATIVE COLITIS AND CROHN'S DISEASE: PROBLEMS OF DIFFERENTIAL DIAGNOSIS." University therapeutic journal 5, no. 3 (2023): 31–40. http://dx.doi.org/10.56871/utj.2023.92.54.003.

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Воспалительные заболевания кишечника (ВЗК) — язвенный колит (ЯК) и болезнь Крона (БК) — заболевания с неизвестной этиологией и тяжелым рецидивирующим течением. Первым этапом обследования больных с подозрением на ВЗК является дифференциальная диагностика с колитами различной этиологии, а также между ЯК и БК. Описываются различные эндоскопические, гистологические, клинические и рентгенологические признаки каждого из ВЗК. Язвенный колит характеризуется поражением только толстой кишки и явлениями ретроградного илеита при вовлечении в процесс восходящей кишки, диффузным поражением сегмента, обязате

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Maev, Igor V., Igor G. Bakulin, Maria I. Skalinskaya, and Ekaterina V. Skazyvaeva. "Inflammatory bowel diseases: Transformation of representations. A review." Terapevticheskii arkhiv 95, no. 12 (2023): 1064–74. http://dx.doi.org/10.26442/00403660.2023.12.202507.

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The global burden of inflammatory bowel disease (IBD) is currently significant and continues to grow due to the increasing prevalence of ulcerative colitis (UC) and Crohn's disease (CD), the increasing costs of diagnosis and treatment, and the high level of disability in patients with this disease. Categories, which leads to the search for risk factors and predictors of aggressive course and extraintestinal manifestations. According to the latest data, the prevalence of UC in Russia is 16.6 per 100 000 population, the annual registered increase is 11.3%; the prevalence of CD is 5.6 per 100 000

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Shapina, M. V., B. A. Nanaeva, and A. V. Vardanyan. "EFFICACY AND SAFETY OF USTEKINUMAB FOR CROHN’S DISEASE (review." Koloproktologia 18, no. 3(69) (2019): 119–30. http://dx.doi.org/10.33878/2073-7556-2019-18-3-119-130.

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Crohn's disease (CD) is a chronic autoimmune disease of the gastrointestinal tract, which mainly affects young people of productive age. Until now, patients with this disease cannot be cured with by conservative therapy or surgery. The effectiveness of drugs for CD is limited, and their use is often accompanied by adverse events. All this creates a need for new drugs, fundamentally different in the action, with high efficiency and a good safety profile. The review is dedicated to a new biological agent for the treatment of CD blocking interleukins 12 and 23, which are involved in the pathogene

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