Academic literature on the topic 'Cronobiologia'
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Journal articles on the topic "Cronobiologia"
Oliveira Bianchi, Larissa Renata. "Análise cienciométrica de artigos publicados na Scielo sobre o tema cronobiologia e depressão sazonal." Arquivos do Museu Dinâmico Interdisciplinar 19, no. 2-3 (June 13, 2016): 18. http://dx.doi.org/10.4025/arqmudi.v19i2-3.28652.
Full textRizzutti, Sueli, Mauro Muszkat, and Carlos José Reis de Campos. "Cronobiologia e Epilepsias." Revista Neurociências 7, no. 2 (April 30, 1999): 69–72. http://dx.doi.org/10.34024/rnc.1999.v7.8961.
Full textSantos, Mónica, and Armando Almeida. "Cronobiologia aplicada à saúde laboral." Revista Portuguesa de Saúde Ocupacional 1 (June 30, 2016): S153—S157. http://dx.doi.org/10.31252/rpso.17.03.2016/2.
Full textAlmondes, Katie Moraes de. "Psicologia da saúde e cronobiologia: diálogo possível?" Psicologia: Ciência e Profissão 33, no. 3 (2013): 646–55. http://dx.doi.org/10.1590/s1414-98932013000300010.
Full textSantos, Mónica, and Armando Almeida. "Cronobiologia aplicada à alimentação, em contexto laboral." Revista Portuguesa de Saúde Ocupacional I (June 30, 2016): S158—S160. http://dx.doi.org/10.31252/rpso.24.05.2016.
Full textMoreno, Claudia Roberta de Castro, Lúcia Rotenberg, Fernando Mazzilli Louzada, Frida Marina Fischer, and Luiz Menna-Barreto. "Medicina da noite: da Cronobiologia à prática clínica." Cadernos de Saúde Pública 24, no. 10 (October 2008): 2453–54. http://dx.doi.org/10.1590/s0102-311x2008001000029.
Full textSilva, Breno Márcio Bottino de Melo, Júlia Ferreira Vieira, Thais Bruna Melo Sousa, and José Carlos Pires Souza. "Cronobiologia do transtorno afetivo bipolar: uma revisão narrativa." Debates em Psiquiatria 12 (July 18, 2022): 1–22. http://dx.doi.org/10.25118/2763-9037.2022.v12.288.
Full textSalles, Ivan S., and Marcos S. Buckeridge. "Cronobiologia vegetal: aspectos fisiológicos de um relógio verde." Revista da Biologia 9, no. 3 (December 2012): 45–49. http://dx.doi.org/10.7594/revbio.09.03.08.
Full textPizzolito, Bianca Araujo, and Edmur Antonio Stoppa. "Cronobiologia e suas Influências nas Vivências de Lazer." Revista Turismo em Análise 23, no. 1 (April 17, 2012): 78. http://dx.doi.org/10.11606/issn.1984-4867.v23i1p78-103.
Full textMenna-Barreto, Luiz, and Cláudia Espírito-Santo. "Tempo e democracia: uma proposta de aproximação do pensamento de Paulo Freire com a Cronobiologia." Revista Estudos Culturais, no. 5 (June 2, 2020): 83–101. http://dx.doi.org/10.11606/issn.2446-7693i5p83-101.
Full textDissertations / Theses on the topic "Cronobiologia"
Andreoli, Carla Parada Pazinatto 1959. "Desempenho academico dos alunos do turno noturno e suas relações com o ciclo vigilia-sono e cronotipo." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311334.
Full textDissertação (mestrado) - Universidade EStadual de Campinas, Faculdade de Ciencias Medicas
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Resumo: Este estudo analisou o desempenho acadêmico, padrão de sono e o cronótipo dos estudantes universitários do turno matutino e noturno. Participaram dessa pesquisa, alunos do Curso de Graduação de Tecnologia em Estética, num total de (n=139), com média de idade de 23,59. Foram utilizados três questionários: a- um para coleta de informações pessoais e profissionais; b - outro para avaliação do ciclo vigília-sono (diário de sono); c- e o Cronótipo, Questionário de Horne e Ostberg (1976). Verificou-se, por meio do diário de sono, as características individuais e os hábitos de sono, correlacionando com o cronótipo e desempenho escolar. Os resultados da análise dos padrões de sono entre as turmas do matutino e noturno, mostraram dados estatisticamente significativos (teste de Mann-Whitney )para as variáveis hora de deitar (p< 0,001), para a hora de dormir (p< 0,001) e para a hora de acordar (p< 0,001) e duração de cochilo com (p =0,009) Quanto à avaliação dos cronótipos, observou-se que, no turno matutino, 15,09% são do cronotipo matutino, 24,53%, tipo vespertino e 60,38%, para o indiferente. Os resultados quanto às variáveis cronótipo e idade mostraram valores significativos (teste Qui-Quadrado), os sujeitos na faixa etária de ? 30 anos são alunos de cronótipo matutino, destes, 52,38% financiam seus próprios estudos, 81,82% trabalham fora, estudam no turno matutino e demonstraram melhor desempenho acadêmico com (p=0,005) Teste de Kruskal-Wallis. Constatou-se pelo coeficiente de correlação de Spearman, que houve valor significativo para a hora de acordar e nota do SPA (r = - 0,217; p= 0,013). Este dado demonstra que, quanto mais tarde a hora de acordar, menor o desempenho acadêmico, podendo sugerir que existe uma relação com o tempo total do sono noturno
Abstract: This study it analyzed the academic performance, standard of sleep and cronotype of the university students of the morning and nocturnal turn. They had participated of this research, pupils of the course of graduation of Technology in Aesthetic, a total of (n=139), with average of age of 23,59. Three questionnaires had been used: to one for collection of personal and professional information; b - another one for evaluation of the sleep-wake cycle (daily of sleep); c- the cronotype, Questionnaire of Horne and Ostberg (1976). It was verified by means of daily of sleep the individual characteristics and the habits of sleep, correlating with cronotype and pertaining to school performance. The results of the analysis of the sleep standards enter the groups of the day and nocturnal, they had shown statistical given significant (test of Mann-Whitney) for the variable hour to lie down (p< 0,001), for the hour to sleep (p< 0,001) and for the hour to wake up (p< 0,001) and duration of nap with (p =0,009) How much to the evaluation of the cronotype, observed that in day turn 15.09% they are of cronotype morning, 24.53% evening type and 60.38% for the indifferent one. The results how much the variable cronotype and age had shown significant values (Qui-Square test), the citizens in the etaria band of ? 30 years are pupils of cronotype morning, of these 52.38% they finance its proper studies, 81.82% work outside study in the morning turn and had better demonstrated academic performance with (p=0,005) Test of Kruskal- Wallis. It was evidenced for (coefficient of correlation of Spearman), that it had significant value for the hour to wake up and notices of the SPA (r = - 0,217; p= 0,013), given that it demonstrates that the more late the hour to wake up, minor the academic performance, being able to suggest that a relation exists with the total time of nocturnal sleep
Mestrado
Enfermagem e Trabalho
Mestre em Enfermagem
Ochiai, Angela Megumi. "Influências do meio ambiente no parto." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/7/7136/tde-08052009-105241/.
Full textBackground: lunar and environmental influences in vaginal delivery remain unclear. We assessed extrinsic influence in obstetric events. Methods: in a secondary line hospital, located in São Paulo city, Brazil, we selected 1,826 days, in which occurred 17,417 admissions for obstetric labor, and we studied influence of air temperature, atmospheric pressure, tides range, and lunar phases in incidence of excess of obstetric labor, defined as more than 9 admissions per day. Z score (standard deviation from mean) of each variable was calculated, and diary difference to indicate increase or decrease was assessed by logistic regression for prediction of admission excess. Two-side P< 0.05 was considered significant. Results: predictors of admission excess were increase of temperature (relative risk: 1.742, P=0.045), and decrease of atmospheric pressure (relative risk: 1.269, p=0.029). Increase of tides range was associated with lower probability of admission excess (relative risk: 0.762, P=0.030). Lunar phases was not predictor of admission excess (P=0,339). Conclusion: By multivariate analysis, increase of temperature and decrease of atmospheric pressure predicted occurrence of excess of obstetric labor admission, and increase of tidal range, as lunar gravitational force measurement, predicted lower probability of admission excess
Campos, EugÃnio de Moura. "Perfil cognitivo, ritmo e padrÃes do sono em pacientes portadores de esquizofrenia." Universidade Federal do CearÃ, 2007. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=2710.
Full textClinical characteristics and symptom severity are heterogeneous in schizophrenia making the course and outcome less predictable. Sleep disturbances have been frequently described in association with this illness and may have deleterious effect on functional abilities. A few studies have described circadian changes in schizophrenia and some suggest a relationship between circadian alterations and poor performance after neuropsychological tests. Previously, it has been shown that patients with schizophrenia have impairment of verbal and visual-spatial working memory. However, many of these tests are laborious, complicated and time consuming. The utility of the several available neuropsychological tests in schizophrenia is not yet totally clarified. We have aimed to study sleep alterations, morning-evening preference, neurognitive function and their relationship with clinical variables. This is a cross-sectional study of patients with schizophrenia on use of conventional or atypical antipsychotic regarding functional abilities, sleep alterations and cognitive function. Assessment procedures involved the use of the Global Assessment of Functioning (GAF) Scale, Cumulative Illness Rating Scale (CIRS), Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), Horne e Ãstberg questionnaire, and a neuropsychological battery that included the WAIS Digit Span Forward and Backward, Corsi block-tapping task (Forward and Backward), Stroop Color Word Interference Test and the Phonemic Verbal Fluency Test. We studied 82 patients (51.2% male) aged 17 to 59 years (35.2Â10.4). Twenty-two were using conventional antipsychotic, 30 olanzapine and 30 risperidone. Poor sleep quality (PSQI>6) was observed in 41 subjects (50%) and excessive daytime sleepiness (ESE≥10) in 20 (24.4%). Female gender was associated with poor sleep quality (P=0.01). A trend of association between quality of sleep and GAF was observed (P=0.07). Worse disability, as evaluated by GAF, was associated with age, reduced number of school years and greater comorbidity severity. In relation to morning-evening preference, eight patients (9.8%) were definitely evening, 39 (47.6%) were moderately evening 33 (40.2%) were indifferent, 2 (2.4%) were moderately morning and none were definitely morning type. Younger patients and of male gender showed more evening preference (F= 6.32; P= 0.01) similar to previous reports in the literature. Frequent comorbidities were related to osteoarticular complaints, psychological symptoms, and metabolic alterations. Neuropsychological tests were altered in the vast majority of patients with values below 80% of historical normal values. The Stroop test was associated with GAF after controlling for age and school years (F= 6.43; P= 0.001). The Digit Span Backward was associated with GAF after controlling for gender, school years and type of antipsychotic (F= 4.76; P= 0.003). The Corsi block-tapping task Forward was associated with GAF after controlling for gender (F= 3.68; P= 0.01). The Corsi block-tapping task Backward was associated with GAF after controlling for gender, number of school years and type of antipsychotic (F=3.03; P= 0.02). The Stroop and Digit Span Backward were best associated with functional ability followed by the Corsi block-tapping task (Forward and Backward). A correlation between female gender and visual-spatial memory as evaluated by the Corsi Block-tapping Task Backward was observed. In conclusion, poor sleep quality is common and more present in women with schizophrenia. A trend between poor sleep quality and functional disability was observed. In general, an evening preference was predominant. Neurocognitive tests were altered in the majority of cases. The Stroop and Digit Span Indirect, two quick and easy to perform tests that evaluate working memory, were those that presented the greater association with global functional ability
Alam, Marilene Farias. "A relevância da cronobiologia no processo saúde-doença : relação do cronotipo com o estilo de vida e saúde." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/56686.
Full textIndividuals differ in their preferences to allocate the time periods of sleep and activity. These inter-individual differences are due partly to the biological clock that controls functions related to gene expression, hormone secretion, body temperature, cognitive and behavioral functions such as sleep-wake cycle. This chronobiological study aimed to evaluate a sample of university students in southern Brazil, the distribution of chronotypes and to study the relationship between chronotype and the following variables: mid- sleep on free days and days of activity (study), and to assess the internal consistency, reliability and agreement between the Munich Chronotype Questionnaire (MCTQ) and the Morningness/Eveningness Questionnaire (MEQ) of Horne and Östberg (HO) to identify chronotypes. By discriminant analysis of sleep parameters for the evening chronotype highlights the importance of obtaining easier predictors to the evening typology since such characteristic has been associated with some risks of mental and behavioral disorders.Two hundred and forty four undergraduate students (59.0% women), 17- 35 years old, were assessed in a cross-sectional study. The Munich ChronoType Questionnaire (MCTQ) was used to evaluate sleep parameters on free days and work days and the Morningness/Eveningness Questionnaire (MEQ) to assess chronotypes. The data were analyzed by the Receiver Operating Characteristic (ROC) curve and a discriminant analysis. The variables that presented the highest discriminant coefficients were mid-sleep on free days (0.89) and sleep onset on free days (0.86). Testing the diagnostic values of mid-sleep phase to identify eveningtype it was observed that the area under the ROC curve was 76%. This study showed a good sensitivity and specificity to identify the evening chronotype with these sleep parameters. We conclude that these parameters are useful to identify evening typology and can be used both to research purposes and clinical practice.
Oda, Gisele Akemi. "Ritmos Biológicos Observados em Insetos Cavernícolas." Universidade de São Paulo, 1997. http://www.teses.usp.br/teses/disponiveis/43/43131/tde-06122013-161839/.
Full textIn this work, we constructed Phase Resetting Curves (PRC) of the infradian biological rhythms of the cave insects Folsomia candida. We used temperature pulses to reset the phases of these rhythms, since the insects are blind. We obtained PRCs with delays only, of the topological Type 1, for the three different pulse durations. This is an unusual behavior, considering the typical responses of the limit-cycle oscillators associated to the majority of the biological rhythms. The dimension of an oscillator determines the PRC types that a system, submitted to pulses at different phases, can present. Simple clocks are associated to a sequence of discrete linked events, each event leading to the next and playing a functional role in generating the rhythmicity. They are unidimensional systems and can\'t present Type O PRCs and singularities, as the two-dimensional limit cycles. Based on the properties of the experimental curves and knowing the phisiological bases of these insect rhythms, we propose a simple clock model for the infradian rhythms studied here.
Umemura, Guilherme Silva. "Análise da ritmicidade circadiana nas transições do horário de verão." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/47/47135/tde-03062015-160918/.
Full textNot informed by the author
Canal, Corretger Maria Mercè. "Efecte de les condicions ambientals en el desenvolupament dels ritmes circadiaris." Doctoral thesis, Universitat de Barcelona, 2001. http://hdl.handle.net/10803/3014.
Full textEl treball s'ha estructurat en dues parts: la primera on s'ha estudiat, en animals sans, els efectes de les condicions ambientals rebudes durant les primeres setmanes de vida en el desenvolupament i funcionalitat del sistema circadiari, i una segona on s'ha treballat amb rates hipertenses de la soca TGR(mREN2)27, amb la mateixa finalitat.
Valentinuzzi, Veronica Sandra. "Modelação temporal de processos de aprendizagem : Implicações praticas e teoricas." [s.n.], 1999. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314121.
Full textTese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia
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Resumo: Estudos da variação temporal de processos de aprendizagem e memória são relativamente escassos e inconsistentes, fundamentalmente, devido à falta de uma padronização dos métodos utilizados e especificação dos tipos de controles necessários, que permitam isolar componentes temporais endógenos da aprendizagem propriamente dita. Assim, no presente trabalho discutimos as dificuldades deste tipo de estudo e sugerimos estratégias que poderiam ajudar a controlar alguns dos fatores mascaradores. Foram realizados três estudos tentando aplicar algumas destas estratégias. No primeiro, analisamos o efeito da hora do dia na habituação a um contexto novo em camundongos, quantificando o comportamento ambulatório por meio de observação direta. Em condições de claroescuro um ritmo diurno foi detectado, porém nenhum efeito temporal foi observado em animais submetidos a um fotoperíodo esqueleto, situação em que se evita os efeitos mascaradores de um ciclo claro-escuro. Estes resultados demonstram que o ciclo de iluminação pode alterar significativamente a resposta a um contexto, reafirmando a necessidade de um controle preciso desta condição externa. Em estudos de ritmicidade de aprendizagem, devido à elevada freqüência de amostragem necessária e à necessidade de testes em horários pouco convenientes, a automatização da medida comportamental resulta indispensável. Assim, no segundo estudo foi validado um equipamento computadorizado para a medida do comportamento de imobilização em situações de condicionamento aversivo. As medidas comportamentais obtidas por este método automático mostraram uma elevada correlação com as medidas obtidas por observação direta. Conseqüentemente, este sistema foi utilizado no terceiro estudo onde se analisou o condicionamento aversivo durante as fases de atividade e de inatividade de camundongos submetidos a um fotoperíodo esqueleto. Uma diferença significativa entre os testes matutinos e os testes vespertinos foi detectada na expressão e extinção do condicionamento aversivo a um contexto, enquanto que nenhum efeito temporal foi observado no condicionamento aversivo a um som. O fato de que estes dois tipos de aprendizagens envolvem estruturas neurais diferentes sugere que o relógio biológico estaria tendo um efeito modulatório nas vias responsáveis pelo condicionamento a um contexto
Abstract: Studies that analyze a temporal variation in learning and memory processes are relatively scattered and inconsistent, mainly due to the lack of systematic methods and specifications of the necessary controls that would allow the dissection of a temporal component in the learning process per se. Here we analyze the difficulties of this kind of study and suggest a few strategies that could help control some of the masking factors. Three studies were performed applying some of these strategies. In the first study we analyzed habituation to a novel environment in mice by quantifying ambulation in an open field through direct observation. Mice submitted to a light-dark cycle showed a diurnal rhythm in learning however, no temporal effect was observed in animals submitted to a skeleton photoperiod (tw015-minute bright light pulses separated by 12 h of green dim light). Under these conditions the masking effects of a light-dark cyc1e are avoided. These results demonstrate that the response to a novel environment is strongly affected by the illumination cycle, thus reinforcing the need for precise control and specification of this condition. When analyzing learning at different times of the day automation of behavioral sCO1:ing becomes essential due to the need for high frequency in data collection and testing which occurs around the clock. Therefore, a second study was performed where a computer-assisted system for scoring freezing behavior in mice during fear conditioning situations was validated. The computer measures obtained during fear conditioning tests showed high correlations with hand-scored freezing. Consequently, this data collection system was used in a third study where fear conditioning was analyzed during the active and inactive phases of mice submitted to a skeleton photoperiod. A significant difference in the expression and extinction rate of context-dependent fear conditioning was observed between mice trained and tested in the morning versus the evening. In contrast, no diurnal rhythm was detected for tone-cued fear conditioning. The biological clock may have a modulating effect on the hippocampal-dependent pathway which underlies context fear conditioning and no effect on the hippocampal-independent pathway underlying tone-fear conditioning
Doutorado
Fisiologia
Doutor em Ciências Biológicas
Santos, Ivan Salles. "Coordenação temporal da relação fonte dreno em plântulas de jatobá (Hymenaea courbaril L.)." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/41/41132/tde-24042012-083753/.
Full textJatobá seedlings have large amounts of carbon reserves in the form of wall constituent polysaccharides, present in their cotyledons. These reserves are initially used in the expansion of the eophylls. After this stage, the seedlings have two sources of carbon, the reserves (which are not fully degraded yet) and autotrophic (understood as photosynthesis) (Santos and Buckeridge, 2004). The constant conditions allowed us to conclude that most of the parameters involved in the photosynthesis process are circadian controlled. This control mechanism has at least two independent oscillatory systems, which are coupled when under the influence of an environmental cycle. The nature of the temporal control of the reserves degradation is yet unclear. Although, evidences are that it\'s being controlled by an endogenous component. We were able to identify, in some cases, a strong influence of the environment, acting directly on the expression of some variables (such as chlorophyll concentration). Finally, we draw a general picture of the temporal control mechanism involved in the source-sink balance (during the establishment phase of this species), in which we were able to integrate all our data and therefore, identify some important control mechanisms involved
Sabino, Flávia Cal [UNIFESP]. "Caracterização molecular do gene Per3 em primatas: foco no sagüi (Callithrix jacchus)." Universidade Federal de São Paulo (UNIFESP), 2009. http://repositorio.unifesp.br/handle/11600/9192.
Full textAssociação Fundo de Incentivo à Psicofarmacologia (AFIP)
Centros de Pesquisa, Inovação e Difusão (CEPID/FAPESP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Os genes Periods (Per1-3) são importantes na geração da ritmicidade circadiana. Mutações nestes genes têm fortes efeitos sobre o ritmo circadiano e estão associados com distúrbios de sono em humanos. Dentre estes genes, o Per3 tem uma característica peculiar, a presença de uma repetição em tandem de número variável na região codificadora. Esta repetição em tandem está associada com o cronotipo (matutino / vespertino), com Síndrome da fase atrasada e homeostase do sono. Sabe-se que o tamanho dessas repetições em tandem varia entre espécies diferentes, sendo que cada repetição tem o tamanho de 54 nucleotídeos. No genoma de sagüi (Callithrix jacchus), esta região possui sete repetições, enquanto que em outros primatas, esta mesma região possui diferentes tamanhos e pode variar de três a cinco repetições. A caracterização e anotação do gene Per3 em outros primatas (como em Homo sapiens) já é bem conhecida, entretanto, tem-se a falta de caracterização e anotação completa do gene Period3 em Callithrix jacchus. Dado o cenário e fatores descritos, e considerando o organismo sagüi um primata de interesse para uso como organismo modelo em diversos estudos na área de ritmos biológicos, apresenta-se neste projeto a caracterização completa do gene Per3 em Callithrix jacchus. Nesta caracterização inclui: a definição de regiões de éxons e regiões de íntrons, pesquisa de polimorfismo, análise de neutralidade, identificação e análise de elementos transponíveis e RNA não-codificante, e comparação do comprimento da região de repetição em tandem entre os primatas do novo mundo. O gene Per3 em sagüi tem 74.739 pares de basess e tem uma pontuação de alinhamento de 77, quando alinhada com a seqüência do gene humano, e 97, quando alinhada com a seqüência de sagüi disponível na plataforma da Universidade da Califórnia Santa Cruz. Há três ilhas CpG e 20 sítios de ligação de fatores de transcrição, identificadas por análises in silico, na região promotora deste gene em sagüi. Ainda foram identificadas 115 inserções de elementos transponíveis no gene Per3, sendo os Long interspersed nuclear elements e os Short interspersed nuclear elements as classes dominantes. Sobre RNA não codificantes foram obtidos 102 possíveis candidatos por meio da predição feita via técnicas de bioinformática que usam a abordagem de análise comparativa com outros primatas. Na região da repetição em tandem, foram encontrados cinco polimorfismos de nucleotídeo único e quatro destes são não-sinônimos. Quando esta região de repetição foi examinada para se verificar polimorfismos de comprimento, apenas um sagüi (em oitenta) apresentou heterozigozidade (sete e seis repetições). Nenhuma repetição em tandem foi encontrada em mamíferos não-primatas. Em primatas do novo mundo existem variações no comprimento desta região de repetição que vão de duas a onze repetições. O seqüenciamento e caracterização do gene Per3 em sagüi permitirá a diversos outros futuros estudos comportamentais usando este animal como organismo modelo.
The Periods genes (Per1-3) are important in the generation of circadian rhythms. Mutations in these genes have strong effects on the circadian rhythm and are associated with sleep disorders in humans. Among these genes, Per3 has a special feature, the presence of a variable number in tandem repeat in the coding region. This repeat in tandem is associated with diurnal preference (morning / afternoon), with DSPS and sleep homeostasis. It is known that the length of these repeats in tandem varies among different species; being that the length of each repetition is 54 nucleotides. In the genome of marmosets (Callithrix jacchus), this region has seven repeats, whereas in other primates, this same region has different lengths and can vary from three to five repetitions. The characterization and annotation of Per3 gene in other primates (as in Homo sapiens) is already well known, however, there has been a lack of characterization and annotation of the Period3 in Callithrix jacchus. In this scenario and considering marmoset as a primate of interest for use as a model organism in several studies in the field of biological rhythms, this project presents a complete characterization of Per3 gene in Callithrix jacchus. In this characterization was included: the definition of exons´ and introns´ regions, the search for polymorphism, the analysis of neutrality, the identification and analysis of transposable elements and non-coding RNA, and comparing the length of the variable number in tandem repeat between New World primates. The Per3 in marmoset has 74,739 base pairs and has an alignment score of 77, when aligned with the sequence of the human gene, and 97, when aligned with the sequence of marmoset available on the platform of the University of California Santa Cruz. Three CpG islands and 20 transcription factors binding sites were identified, by in silico analysis, in the promoter region of this gene in the marmoset. Were also identified 115 insertions of transposable elements in Per3 gene, and the long interspersed nuclear elements and short interspersed nuclear elements of the dominant classes. About non-coding RNA, 102 possible candidates were obtained through the prediction via bioinformatics techniques that use the analysis approach of comparison with other primates. In the region of repeat in tandem, were found five single nucleotide polymorphisms and four of these are non-synonymous. When this region of repeat was examined to verify the polymorphism length, only one marmoset (in eighty) showed to be heterozygous (seven and six replicates). No variable number repeat in tandem was found in non-primate mammals. In the new world primates there are variations in the length of this repeat region, ranging from two to eleven repeats. The sequencing and characterization of the gene Per3 in marmoset will allow several other future behavioral studies using this animal as a model organism.
FAPESP: 04/15837-4
CEPID/FAPESP: 98/143003-3
TEDE
BV UNIFESP: Teses e dissertações
Books on the topic "Cronobiologia"
Rose, Kenneth Jon. El cuerpo humano: Una ma quina precisa. Me xico: Editorial Limusa, 1992.
Find full textNoguera, Antoni Díez i. Los ritmos de la vida: Cómo la cronobiología nos ayuda a vivir mejor. Barcelona, Spain: Universtitat de Barcelona, 2015.
Find full textMohammad, Shafii, and Shafii Sharon Lee, eds. Melatonin in psychiatric and neoplastic disorders. Washington, DC: American Psychiatric Press, 1998.
Find full textIvanov, Lucian, and Nicolae Ivanov. Cronobiologia Pentru Toți. Independently Published, 2021.
Find full textCapone, Domenico, José Manoel Jansen, Agnaldo José Lopes, Ursula Jansen, and Teresinha Yoshiko Maeda. Medicina Da Noite: Da Cronobiologia à Prática Clínica. Fundacao Oswaldo Cruz, 2007.
Find full textP, Cardinali Daniel, Jordá Catalá Juan J, and Sánchez Barceló Emilio J, eds. Introducción a la cronobiología: Fisiología de los ritmos biológicos. [Cantabria]: Universidad de Cantabria, 1994.
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Alves, Bruna Heloysa, Felício de Freitas Netto, Mariane Marcelino Fernandes, Ana Letícia Grigol Dias, and Fabiana Postiglione Mansani. "AVALIAÇÃO DA QUALIDADE DE VIDA ASSOCIADA À CRONOBIOLOGIA EM TRABALHADORES DE TURNO DE UM HOSPITAL UNIVERSITÁRIO DOS CAMPOS GERAIS." In As Ciências Biológicas e a Interface com vários Saberes 2, 109–20. Atena Editora, 2020. http://dx.doi.org/10.22533/at.ed.38220021010.
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