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Journal articles on the topic 'Croscarmellose sodium and Sodium starch glycolate'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

K., Rekha Rani Y. Navya Reddy R. Mohana Priya G.Anusha and T. Spurthi. "FORMULATION AND EVALUATION OF ORAL DISINTEGRATION TABLETS OF OMEPRAZOLE." indo American Journal of Pharmaceutical Sciences 04, no. 05 (2017): 1391–97. https://doi.org/10.5281/zenodo.804918.

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Omeprazole fast disintegrating tablets were prepared by using different superdisintegrants like crospovidone, croscarmellose sodium and Sodium starch glycolate by direct compression. Precompression parameters were conducted for all formulations blend and were found to be satisfactory. The prepared tablets were evaluated for various parameters like content uniformity, hardness, friability, wetting time, water absorption ratio, disintegration time and In-vitro dissolution. The results indicated that the tablets complied with the official specifications. The disintegration studies shown that the

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Chandrasekar, R., Prudhvi Raj V, and Sameer Shaik. "Formulation Development and Invitro Evaluation of Gliclazide Pellets using Superdisintegrants by Extrusion Spheronization Technique." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 16, no. 1 (2023): 6266–80. http://dx.doi.org/10.37285/ijpsn.2023.16.1.2.

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Introduction: Gliclazide is a sulfonylurea derivative used for the treatment of type 2 Diabetes, it is an anti-diabetic drug it is marketed under the brand name Diamicron. It is taken orally and used when dietary changes, lack of exercise, and weight loss are not sufficient.  Aim: The principal objective of this work was to develop, formulate and evaluate the pellet formulations prepared with the incorporation of different super disintegrants in different ratios and in different combinations. In this research work, the drug gliclazide was chosen as a model drug and it was formulated into

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Obaidat, Aiman, та Rana Obaidat. "Development and evaluation of fast-dissolving tablets of meloxicam-β-cyclodextrin complex prepared by direct compression". Acta Pharmaceutica 61, № 1 (2011): 83–91. http://dx.doi.org/10.2478/v10007-011-0005-7.

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Development and evaluation of fast-dissolving tablets of meloxicam-β-cyclodextrin complex prepared by direct compressionThe aim of this study was to prepare fast-dissolving tablets of meloxicam after its complexation with β-cyclodextrin (β-CD) and to investigate the effect of using different superdisintegrants on the disintegration and release of meloxicam from the tablets. A complex of meloxicam with β-CD was prepared by spray drying and then compressed in the form of tablets utilizing the direct compression technique. Three superdisintegrants were employed at various levels - sodium starch g

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Noma, S. T., B. A. Tytler, A. K. Olowosulu, and Z. S. Yahaya. "Evaluation of the disintegrant property of co-processed sorghum starch-silicon dioxide excipient in chlorpheniramine orodispersible tablets." Journal of Basic and Social Pharmacy Research 1, no. 3 (2020): 1–10. http://dx.doi.org/10.52968/27452073.

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Background: Fast dissolving or orodispersible tablets are highly desirablein groups such as children, uncooperative, nauseated, or those on reduced water intake to ease the difficulties associated with swallowing the conventional solid dosage forms. Objectives: The work aimed to evaluate the disintegrant property of sorghum starch-silicon dioxide co-processed mixture in the formulation of chlorpheniramine orodispersible tablets. Method: Different batches of orodispersible tablets of chlorpheniramine maleate (4 mg) were prepared by direct compression method using Avicel® as a bulking agent and

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Pokhrel, Gopal, Ganga Kunwar, Jun Devi Rai, Sheela Thapa, Sudip Dhakal, and Prashant Basnet. "Formulation and in-vitro Evaluation of Oro-dispersible tablets of Indomethacin." Nepal Journal of Health Sciences 2, no. 1 (2022): 90–97. http://dx.doi.org/10.3126/njhs.v2i1.47172.

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Introduction: Oro-dispersible tablets are rapidly dissolved in saliva without the need for water and are beneficial for renal impaired, bedridden and psychiatric patients. Objective: The study aimed to formulate oro-dispersible tablets of indomethacin with reduced adverse effects, better patient compliance, faster action, and convenience for patients. Methods: Oro-dispersible tablets of indomethacin were prepared using three different super disintegrants; crospovidone, croscarmellose sodium and sodium starch glycolate with three different concentrations (2.5%, 5.2%, and 7.7%) by direct compres

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Elawni, Alaa E., Zuheir Osman, Mohammed Salih, Waleed Elballa, and Mohammed Shayoub. "Implementation and comparison of different taste masking techniques to design and assess dispersible tablet formulations." Journal of Applied Pharmaceutical Research 10, no. 4 (2022): 1–13. http://dx.doi.org/10.18231/j.joapr.2022.10.4.1.13.

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The objective of this study was to assess the efficacy of several taste-masking techniques and to study the impact of different formulation variables on the physicochemical properties of dispersible tablets containing Ranitidine as a model drug. Ranitidine powder was taste masked using various techniques. Factorial design (24) was applied to design the set of tablet formulations. The four factors implemented were the manufacturing method, filler type, superdisintegrant type and superdisintegrant concentration. Levels selected were direct compression and wet granulation for the manufacturing me

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Endang Diyah Ikasari. "Optimization Of Sodium Croscarmellose And Sodium Starch Glycolate In Orally Disintegrating Tablets (Odt) Acetosal." Media Farmasi Indonesia 20, no. 1 (2025): 15–23. https://doi.org/10.53359/mfi.v20i1.289.

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Acetosal is a drug that is included in the NSAID class which has anticoagulant properties. Acetosal has low bioavailability due to first-pass effect metabolism, so it is formulated in ODT form to increase the bioavailability of acetosal. This research aims to determine the effect of croscarmellose sodium and sodium starch glycolate concentrations as superdisintegrants on the physical characteristics of acetosal ODT and to determine the concentrations of croscarmellose sodium and sodium starch glycolate as superdisintegrants that produce acetosal ODT with optimum physical characteristics. The r

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Shahidulla, SM, and Tayyaba Jeelani. "Formulation and In-Vitro Evaluation of Taste Masked Fast Disintegrating Tablets of Labetalol Hydrochloride by Wet Granulation Technique." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 442–49. http://dx.doi.org/10.22270/jddt.v9i4-a.3506.

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Labetalol Hydrochloride is a β-blocker generally indicated for the treatment of hypertension, and it is extensively metabolized due to the hepatic metabolism. In the present work, an attempt was made to mask the taste by Solid Dispersion technique, with a formulation into Fast Disintegrating dosage form, using superdisintegrants such as Cross carmellose sodium (CCS), crospovidone (CP) and sodium starch glycolate (SSG). The complexes of Labetalol hydrochloride with HP-β-CD (1:3 ratio) were prepared by Co-precipitation method. Using the drug HP-β-CD complex, Fast Disintegrating tablets were prep

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Sujit, S. Shinde* Madan k. Shinde Avinash A. Bhagat Sachitanand Balaji Biradar. "Formulation And Evaluation Of Fast Dissolving Sodium Diclofenac Sodium Tablet." International Journal in Pharmaceutical Sciences 2, no. 5 (2024): 1761–74. https://doi.org/10.5281/zenodo.11400826.

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The present study was aimed to formulate, evaluate, and optimize a tablet that disintegrates and dissolved rapidly toshow a rapid onset action. Diclofenac sodium, non-steroidal- inflammatory, analgesic, and pyretic properties were selected asa model drug. Diclofenac sodium is among the most extensivelyused Non-steroidal anti-inflammatory drugs, employed inmucosal skeletal complaints, especially arthritis. In the present study, an attempt has been made to prepare fast dissolvingtablets of diclofenac sodium using super disintegrants like sodium starch Glycolate, Croscarmellose sodium, Crospovido

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Shinkar, Dattatraya M., Pooja S. Aher, Parag D. Kothawade, and Avish D. Maru. "FORMULATION AND IN VITRO EVALUATION OF FAST DISSOLVING TABLET OF VERAPAMIL HYDROCHLORIDE." International Journal of Pharmacy and Pharmaceutical Sciences 10, no. 10 (2018): 93. http://dx.doi.org/10.22159/ijpps.2018v10i10.28714.

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Objective: The main objective of this research work was to formulate and evaluate fast dissolving tablet of verapamil hydrochloride for the treatment of hypertension.Methods: In this study, fast dissolving tablet were prepared by wet granulation method by using croscarmellose sodium and sodium starch glycolate as superdisintegrants in the concentration of 2%, 4%, and 6%. Polyvinyl pyrollidone K30 is used as a binder. The designed tablets were subjected to various assessment parameters like friability test, hardness test, disintegration test, wetting time, in vitro drug release and drug content

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ÇOMOĞLU, Tansel. "FARKLI SÜPER DAĞITICILARIN KETOPROFEN İÇEREN AĞIZDA DAĞILAN TABLETLERİN İN VİTRO KARAKTERİZASYON PARAMETRELERİ ÜZERİNDEKİ ETKİSİNİN DEĞERLENDİRİLMESİ." Ankara Universitesi Eczacilik Fakultesi Dergisi 48, no. 2 (2024): 10. http://dx.doi.org/10.33483/jfpau.1425266.

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Objective: Orally Disintegrating Tablets (ODTs) have revolutionized pharmaceutical drug delivery, offering a patient-friendly alternative for those struggling with conventional tablet swallowing. This study delves into the impact of superdisintegrants (crospovidone, sodium starch glycolate, and croscarmellose sodium) on the in vitro characterization of Ketoprofen-containing ODTs. ODTs are designed to rapidly disintegrate in the oral cavity without water, enhancing patient compliance, ensuring faster therapeutic onset, and providing convenience. Material and Method: The micromeritic properties

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Rao, N. G. Raghavendra, Tarun Patel, and Rathan Kumar. "Development of Fast Dissolving Carbamazepine Tablets: Effect of Functionality of Superdisintegrants." International Journal of Pharmaceutical Sciences and Nanotechnology 3, no. 1 (2010): 824–33. http://dx.doi.org/10.37285/ijpsn.2010.3.1.5.

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Carbamazepine, a dibenzapine derivative with structure resembling that of tricyclic antidepressants, is used in the treatment of epilepsy. The major problem of this drug is very low solubility in biological fluids and poor bioavailability after oral administration. Carbamazepine fast dissolving tablets (FDT) have been prepared by direct compression method. Effects of superdisintegrants (such as croscarmellose sodium, crospovidone and sodium starch glycolate) on wetting time, disintegrating time, drug content, in vitro release, and stability parameters have been studied. The prepared tablets we

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Nzekwe, M. U., A. K. Olowosulu, Y. E. Apeji, and T. O. Olurishe. "EVALUATION OF THE EFFECT OF VARIOUS SUPERDISINTEGRANTS ON THE DRUG RELEASE PROFILE OF OMEPRAZOLE CORE TABLETS." Archives of Pharmaceutical Sciences and Biotechnology Journal 4, no. 2 (2025): 48–57. https://doi.org/10.47514/apsbj.2024.4.2.005.

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Background: Superdisintegrants play a crucial role in enhancing tablet disintegration and, consequently, drug release. Omeprazole, a proton pump inhibitor used in treating gastroesophageal reflux disease (GERD), will benefit from rapid disintegration and dissolution to ensure prompt therapeutic action. Aim: The study investigated the influence of three distinct superdisintegrants—croscarmellose sodium, sodium starch glycolate, and crospovidone—on the physical and functional properties of omeprazole core tablets. Methods: Tablets were formulated with varying concentrations of each superdisinteg

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Choudhury, Priyanka, Pulak Deb, and Suvakanta Dash. "FORMULATION AND STATISTICAL OPTIMIZATION OF BILAYER SUBLINGUAL TABLETS OF LEVOCETIRIZINE HYDROCHLORIDE AND AMBROXOL HYDROCHLORIDE." Asian Journal of Pharmaceutical and Clinical Research 9, no. 5 (2016): 228. http://dx.doi.org/10.22159/ajpcr.2016.v9i5.13343.

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ABSTRACTObjective: The aim of the present study is to formulate and optimize bilayer sublingual tablets of Levocetrizine hydrochloride and Ambroxolhydrochloride using a 2 response surface methodology employing design expert-10.0. Sodium starch glycolate and Camphor were selected asindependent variables while disintegration time (sec) and water absorption ratio (%) were considered as responses. 3Methods: The bilayer sublingual tablets were prepared by direct compression and evaluated for various evaluation parameters including hardness,thickness, friability, drug content uniformity, wetting tim

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Naji, Ghada Hamid, Worood Hameed Al-Zheery, and Noor Yousif Fareed. "DESIGN AND IN VITRO EVALUATION OF ACRIVASTINE AS ORODISPERSIBLE TABLET USING DIRECT COMPRESSION METHOD." Wiadomości Lekarskie 76, no. 1 (2023): 170–74. http://dx.doi.org/10.36740/wlek202301123.

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The aim: This study aimed to develop mouth-dissolving tablets of Acrivastine, an antihistamine medication, in order to increase its oral bioavailability. Materials and methods: Different super disintegrants, such as crospovidone, croscarmellose sodium, and sodium starch glycolate, were used to make Acrivastine oral dispersible tablets (ODTs). These super disintegrants were utilized in various concentrations. The formulation (F3) with 6% w/w crospovidone had a fast disintegration time (less than 30 seconds) and practically total drug release within 10 minutes. All of the formulations were made

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Divya, B., J. Sreekanth, and D. Satyavati. "Development of Extended Release Formulations of Ilaprazole Tablets." Journal of Drug Delivery and Therapeutics 9, no. 3 (2019): 8–12. http://dx.doi.org/10.22270/jddt.v9i3.2811.

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Extended release products are designed to release their medication in a controlled manner at a predetermined rate, duration, and location to achieve and maintain optimum therapeutic blood levels of a drug. The objective of the study is to formulate and evaluate Ilaprazole Controlled release tablets comparable to the innovator product. F1-F9 formulations were prepared using varying concentrations of super disintegrates like Crospovidone, Croscarmellose sodium and Sodium starch glycolate in different concentrations. Based on the hardness, friability, weight variation, drug content, F6 formulatio

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Kumar, Y. Shravan, Prashanthi Patel, Sravanthi Ch, and Rashmi B. "Formulation and Evaluation of Taste Masked Oral Disintegrating Tablets of Aripiprazole." International Journal of Pharmaceutical Sciences and Nanotechnology 8, no. 1 (2015): 2723–34. http://dx.doi.org/10.37285/ijpsn.2015.8.1.4.

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 Aripiprazole is an atypical antipsychotic agent used for treatment of schizophrenia, bipolar disorder and major depressive disorders. In the present work, oral disintegrating tablets of aripiprazole were developed to enhance the patient compliance and provide rapid onset of action. The efficacy of aripiprazole is mediated through a combination of partial agonist activity at dopamine D2 and serotonin 5HT-1A receptors and antagonist activity at 5HT-2A receptors. It has a bitter taste and poor-solubility in water. Thus, the main objective of the study is to formulate taste masked oral disi

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Faroongsarng, Damrongsak, and Garnet E. Peck. "Thermal porosity analysis of croscarmellose sodium and sodium starch glycolate by differential scanning calorimetry." AAPS PharmSciTech 4, no. 4 (2003): 531–38. http://dx.doi.org/10.1208/pt040467.

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Priya, V. A. Vamshi, G. Chandra Sekhara Rao, D. Srinivas Reddy, and V. Prabhakar Reddy. "The Effect of Different Superdisintegrants and their Concentrations on the Dissolution of Topiramate Immediate Release Tablets." International Journal of Pharmaceutical Sciences and Nanotechnology 2, no. 2 (2009): 531–5366. http://dx.doi.org/10.37285/ijpsn.2009.2.2.6.

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The purpose of this study was to investigate the efficiency of superdisintegrants: sodium starch glycolate, croscarmellose sodium and crospovidone in promoting tablet disintegration and drug dissolution of Topiramate immediate release tablets. The efficiency of superdisintegrants was tested, by considering four concentrations, viz., like 2%, 3%, 4% and 5% in the formulations. The dissolution was carried out in USP apparatus II at 50 rpm with distilled water as a dissolution medium. The dissolution rate of the model drug topiramate was found highly dependent on the tablet disintegration, on the

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Sandeep, D. S., R. Narayana Charyulu, and Prashant Nayak. "COMPARATIVE STUDY OF SUPERDISINTEGRANTS USING ANTIEMETIC DRUG AS A MODEL." Journal of Health and Allied Sciences NU 05, no. 01 (2015): 040–44. http://dx.doi.org/10.1055/s-0040-1703861.

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AbstractIn the present investigation comparison of three different superdisintegrants was carried out by formulating orally disintegrating tablets. Promethazine HCl was used as model drug which is an antiemetic drug. Sodium starch glycolate, croscarmellose and crospovidone were selected as superdisintegrants and each one was used in three different concentrations (2%, 3.5% and 5%). The drug-polymer compatibility was ruled out by FTIR studies. A total of nine formulations (PF1-PF9) were made by direct compression. All prepared formulations were evaluated for weight variation, hardness, friabili

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Bindal, Rishabh, and Arpna Indurkhya. "Formulation and Evaluation of Ketorolac Tromethamine Mouth Dissolving Tablets." Journal of Drug Delivery and Therapeutics 11, no. 1 (2021): 60–64. http://dx.doi.org/10.22270/jddt.v11i1.4502.

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Due to more versatility and comfort, mouth dissolving tablets are the most advanced type of oral solid dosage forms. Compared to conventional tablets, it increases the effectiveness of APIs by dissolving within a minute in the oral cavity after contact with less saliva, without chewing and without the need for water for administration. Mouth Dissolving Tablets of Ketorolac tromethamine were prepared by direct compression method using various superdisintegrants like crospovidone, Croscarmellose sodium, and Sodium starch glycolate in different concentrations. Prepared tablets were evaluated for

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Y., Shiva Kumar* Dr.T. Mangilal Dr. M. Ravi Kumar J. Naveen. "PREPARATION AND EVALUATION OF TAPENTADOL MOUTH DISSOLVING TABLETS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 04 (2019): 8726–36. https://doi.org/10.5281/zenodo.2656643.

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<em>Mouth dissolving tablets are solid dosage forms containing tapentadol as active pharmaceutical ingredient which has analgesic effect, and has superdistegrants like croscarmellose sodium and starch glycolate which disintegrates fast usually less than 60 seconds without the need of water when placed on the tongue. To prepare and evaluate tapentadol mouth dissolving tablet by using direct compression method  and to determine the effect of formulation process and the excipients. Tapentadol MDT were formulated by using ingredients and superdisintegrants like sodium starch glycolate and cro

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Siva, Sindhura.P, and Duraivel.S. "Formulation and Evaluation of Gastroretentive Dosage form of Ciprofloxacin Hydrochloride." International Journal of Current Pharmaceutical Review and Research 3, no. 4 (2013): 105–9. https://doi.org/10.5281/zenodo.12691260.

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The present study aims at developing a Gastroretentive swellable and floating matrix tablet formulation ofciprofloxacin hydrochloride for the effective treatment of infections caused by susceptible organisms.Ciprofloxacin hydrochloride is a fluoroquinoline antibiotic drug. Ciprofloxacin HCl is more stable in acidicmedium and it has a narrow absorption window which is sited at stomach and proximal portions of the smallintestine, so it fulfils the required criteria for selection of drug for Gastroretentive dosage form. CiprofloxacinHCl Gastroretentive tablets were formulated by using wet granula

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Berardi, Alberto, Pauline H. M. Janssen, and Bastiaan H. J. Dickhoff. "Technical insight into potential functional-related characteristics (FRCs) of sodium starch glycolate, croscarmellose sodium and crospovidone." Journal of Drug Delivery Science and Technology 70 (April 2022): 103261. http://dx.doi.org/10.1016/j.jddst.2022.103261.

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Yaakub, Nur Ashikin, Mohd Shamsul Anuar, and Suraya Mohd Tahir. "Compaction behaviour and mechanical strength of lactose-sodium starch glycolate and lactose-croscarmellose sodium binary tablets." IOP Conference Series: Materials Science and Engineering 342 (April 2018): 012026. http://dx.doi.org/10.1088/1757-899x/342/1/012026.

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INDURKHYA, ARPNA, MAHENDRA PATEL, and MASHEER AHMED KHAN. "DEVELOPMENT AND CHARACTERIZATION OF TRANDOLAPRIL IMMEDIATE RELEASE TABLETS USING DIFFERENT SUPERDISINTEGRATING AGENTS." Current Research in Pharmaceutical Sciences 13, no. 1 (2023): 70–77. http://dx.doi.org/10.24092/crps.2023.130106.

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A potent non-sulfhydryl prodrug, trandolapril is transformed into the active substance, trandolaprilat, in the liver. For obese individuals with mild-to-moderate essential hypertension, Trandolapril is effective and safe. The elimination t1/2 of trandolapril and trandolaprilat are approximately 6 hours and 16–24 hours, respectively. The goal of present work is to develop the Trandolapril immediate release tablet using various superdisintegrants. Crospovidone, Sodium starch glycolate and Croscarmellose sodium in concentrations of 2%, 4%, and 6% were used as superdisintegrating agents for the op

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Yousaf, Abid, Faiza Naheed, Yasser Shahzad, Talib Hussain, and Tariq Mahmood. "Influence of sodium starch glycolate, croscarmellose sodium and crospovidone on disintegration and dissolution of stevia-loaded tablets." Polymers in Medicine 49, no. 1 (2019): 19–26. http://dx.doi.org/10.17219/pim/111516.

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Ayyappan, T., C. Poojitha, and T. Vetrichelvan. "Formulation design, optimization & in vitro evaluation of novel orodissolving tablets of efavirenz for hiv infections." Bangladesh Journal of Scientific and Industrial Research 49, no. 3 (2015): 173–80. http://dx.doi.org/10.3329/bjsir.v49i3.22131.

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In the present work, orodissolving tablets of Efavirenz were prepared by direct compression method with a view to enhance patient compliance. A 23 full factorial design was applied to investigate the combined effect of three formulation variables. Amount of crospovidone, croscarmellose sodium and sodium starch glycolate were used as superdisintegrant material along with direct compressible mannitol to enhance mouth feel. The prepared batches of tablets were evaluated for hardness, friability, weight variation, disintegration time, wetting time, drug content and in-vitro dissolution studies. Ba

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Jagdale, Swati Changdeo, Vinayak Narhari Jadhav, Aniruddha Rajaram Chabukswar, and Bhanudas Shankar Kuchekar. "Solubility enhancement, physicochemical characterization and formulation of fast-dissolving tablet of nifedipine-betacyclodextrin complexes." Brazilian Journal of Pharmaceutical Sciences 48, no. 1 (2012): 131–45. http://dx.doi.org/10.1590/s1984-82502012000100015.

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The main objective of the study was to enhance the dissolution of nifedipine, a poorly water soluble drug by betacyclodextrin complexation and to study the effect of the preparation method on the in vitro dissolution profile. The stoichiometric ratio determined by phase solubility analysis for inclusion complexation of nifedipine with β-cyclodextrin was 1:1. Binary complex was prepared by different methods and was further characterized using XRD, DSC and FT-IR. A saturation solubility study was carried out to evaluate the increase in solubility of nifedipine. The optimized complex was formulat

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Siddheshwar, Suhas Shivaji, Asmita Bhausaheb Ghorpade, Someshwar Dattatraya Mankar, and Santosh Bhausaheb Dighe. "Formulation and Drug Release Study of Rivaroxaban Oral Disintegrating Tablets Using Various Super-Disintegrants." International Journal of Experimental Research and Review 36 (December 30, 2023): 147–55. http://dx.doi.org/10.52756/ijerr.2023.v36.014.

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This study aims to improve Rivaroxaban's solubility, dissolution, and bioavailability. Orally disintegrating tablets (ODTs) made with super-disintegrants like crospovidone, sodium starch glycolate, and cross-carmellose sodium will do this. Tablet preparation used direct compression and formulation optimization with design expert software. After a thorough factorial design and evaluation of pre- and post-compression parameters, the F3 batch, which contained Rivaroxaban (7.97%), Crospovidone (3.59%), Croscarmellose sodium (5.18%), Sodium Starch Glycolate (5.18%), Lactose Anhydrous (31.08%), Mann

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S. Jabbar, Mohammed, and Yehia I. Khalil. "Formulation of Metoprolol Bilayer Tablets as an Oral Modified Release Dosage Form." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 19, no. 1 (2017): 21–30. http://dx.doi.org/10.31351/vol19iss1pp21-30.

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Metoprolol is a Î²1 adrenergic blocker used in treatment of heart diseases. Metoprolol (100mg) tablets was formulated as a modified release oral system utilizing the concept of bilayer system, first layer contained (30mg) as immediate release and the other (70mg) in the sustained release matrix. The immediate release layer consisted of lactose or microcrystalline cellulose as diluents with sodium starch glycolate or sodium croscarmellose as disintegrants. The result showed that the layer contains microcrystalline cellulose and 2% sodium starch glycolate gave disintegration time similar to that

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Thulluru, Ashok, Veeravalli Kumar Sai, Pavan Kumar M, and Roshitha B. "EFFECT OF EFFERVESCENCE IN COMBINATION WITH SUPERDISINTEGRANTS IN THE FORMULATION OF PROPRANOLOL HCL ORAL DISINTEGRATING TABLETS." Asian Journal of Pharmaceutical and Clinical Research 10, no. 3 (2017): 227. http://dx.doi.org/10.22159/ajpcr.2017.v10i3.16096.

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ABSTRACTObjective: The current research work is intended to formulate propranolol HCl (PLH) as orally disintegrating tablet (ODT). It is also intending to checkthe superiority in a combination of superdisintegrants and effervescent mixture than the use of superdisintegrants alone by a direct compressiontechnique. To fasten the onset of action and thereby enhancing the bioavailability of PLH in comparison to its conventional tablets.Methods: Standard calibration curve of PLH was obtained in pH 6.8 phosphate buffer by spectrophotometric method, drug-excipient compatibilitystudies were carried by

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Moghal, Md Mizanur Rahman, Sujit Chandra Mazumder, Dilshad Noor Lira, and Abu Shara Shamsur Rouf. "Fabrication and in vitro Evaluation of Allopurinol Fast Dissolving Tablets Using Croscarmellose Sodium, Sodium Starch Glycolate and Crospovidone as Superdisintegrants." Dhaka University Journal of Pharmaceutical Sciences 15, no. 1 (2016): 73–81. http://dx.doi.org/10.3329/dujps.v15i1.29199.

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The main objective of the study was to formulate fast dissolving tablets of allopurinol to achieve better dissolution rate and further improving the bioavailability to provide a quick onset of action. Nine formulations of fast dissolving tablets of allopurinol were prepared by direct compression technique using croscarmellose sodium (Group A), sodium starch glycolate (Group B) and crospovidone (Group C) as superdisintegrants in different concentrations. All formulations showed satisfactory mechanical strength, uniform weight & drug content, and lesser wetting time & dispersion time. In

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Shobana, K. "FORMULATION AND EVALUATION OF PIROXICAM FAST DISSOLVING TABLETS." Journal of Medical pharmaceutical and allied sciences 10, no. 3 (2021): 2804–8. http://dx.doi.org/10.22270/jmpas.v10i3.1064.

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Piroxicam is an analgesic, antipyretic and anti-inflammatory effects drugs, used to reduce pain, swelling joint stiffness from osteoarthritis, rheumatoid arthritis and by inhibiting prostaglandin synthetase. In the research work, seven formulations (F1 to F7) were prepared direct compression method by using 3 superdisintegrants namely Crospovidone, Crosscarmellose sodium and Sodium starch glycolate in two ratio (1:0.5 and 1:1) and F7 (without superdisintegrant). All the formulations evaluated various post compression parameters thickness, weight variation, disintegration time, hardness, friabi

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Parveen, Sadia, Ravindra Pal Singh, Arsh Chanana, and Gulshan Rathore. "Revolutionizing Apixaban Release: Exploring Wet Granulation and Superdisintegrant Synergy for Improved Delivery Profiles." International Journal of Biochemistry Research & Review 33, no. 4 (2024): 1–10. http://dx.doi.org/10.9734/ijbcrr/2024/v33i4865.

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The aim of the present research was to formulate and evaluate immediate release tablet of apixaban. In this research study, we are formulating apixaban by wet granulation method. Previously research has been conducted based on dry granulation and direct compression methods. The proposed wet granulation method has several advantages in terms of feasibility and cost effectiveness. The present formulation comprises of comparative evaluation between disintegrants such as sodium starch glycolate (SSG), and croscarmellose sodium (CCS), among which CCS was found to have optimum results. Superdi

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P., Vijayanand, Sridevi P., and Bhagavan Raju M. "DEVELOPMENT AND OPTIMIZATION OF ORODISPERSIBLE TABLETS OF CARVEDILOL BY COMBINATION OF SUPER-DISINTEGRANTS ADDITION AND SUBLIMATION TECHNIQUES." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 7 (2017): 155. http://dx.doi.org/10.22159/ijpps.2017v9i7.19161.

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Objective: Objective of the present research work was to prepare orodispersible tablets of carvedilol (CDL) for dysphagic patients.Methods: Carvedilol, an anti-hypertensive drug, was chosen as a model drug in this study. Orodispersible tablets of carvedilol were prepared using different super-disintegrating agents such as crospovidone, croscarmellose sodium and sodium starch glycolate at different concentrations. The best formulation was selected based on disintegration and dissolution profile that was further taken for sublimation studies using camphor, menthol and thymol. Drug-excipients int

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Pradyumna Chaudhari, Shanti Saran Koiri, Ashish Lamsal, and Roshan Kumar Mehta. "Formulation and Evaluation of Fast Disintegrating Tablet of Salbutamol Sulphate." Journal of Universal College of Medical Sciences 12, no. 02 (2024): 29–33. http://dx.doi.org/10.3126/jucms.v12i02.69619.

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INTRODUCTION When put on the tongue, fast dissolving tablets immediately dissolve, often in a matter of seconds. They do not need any additional water to make them easier to swallow. Salbutamol sulphate fast disintegrating tablets have a higher bioavailability and dissolving rate. MATERIAL AND METHODS This experimental study was conducted in the Pharmaceutic laboratory of Department of Pharmacy at Universal College of Medical Sciences, Bhairahawa, Nepal from February 2022 to July 2022. A tablet was created utilizing the direct compression method employing mannitol as a diluent and various quan

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Kute, S. Shivaji*1 Sonwane Sonali S*2 Jadhav Vaibhav A2. "Super Disintegrants: An Overview." International Journal in Pharmaceutical Sciences 2, no. 1 (2024): 77–89. https://doi.org/10.5281/zenodo.10464297.

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Disintegrants play a crucial role as excipients in solid oral formulations. In immediate release and oral dispersible tablet formulations, super disintegrants like croscarmellose sodium, sodium starch glycolate, crospovidone, and polacrilin potassium are added in small quantities to counteract the effects of compression and binder after administration. The hygroscopic nature of these super disintegrants facilitates the penetration of water into the tablet matrix, while their cross-linkage reduces solubility in water. This article provides an overview of various factors that can influence the f

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R, Kundharaju, and Kumar CSP. "Formulation and Selection of Immediate Release Layer for Designing the Paracetamol Sustained Release Tablets Based on In vitro Profile." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 04 (2024): 1090–98. https://doi.org/10.25258/ijddt.14.4.47.

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This study focused on designing paracetamol immediate release (IR) layers using three disintegrants- Banana starch (BS), Sodium starch glycolate (SSG), and Croscarmellose sodium (CCS)- at concentrations of 2%, 4%, 6%, and 8% (w/w).A total of 24 formulations are prepared: 12 via direct compression (IL1-IL12) and 12 via wet granulation (IL13-IL24). Pre-compression properties (bulk density: 0.45-0.48 g/cm3, tapped density: 0.55-0.60 g/cm3, Carr’s index: 11.8%-20%, Hausner’s ratio: 1.22-1.25) and post-compression parameters (weight variation: 0.9%-1.6%, hardness: 5.45-5.6kg/cm2, friability: 0.1%-0

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Donthu Raj Kiran, Sai Sravanthi T, Ramakrishnan V та Naveen P. "Utilization and analyzation of pregabalin tablets for easy dissolving for diabatic neuropathy treatment using simple γ-amino butyric corrosive". International Journal of Research in Pharmaceutical Sciences 11, SPL4 (2020): 450–56. http://dx.doi.org/10.26452/ijrps.v11ispl4.3881.

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Pregabalin (PRE) has been considered as a basic simple of γ-aminobutyric corrosive, which is utilized to treat unmanageable incomplete seizures, diabetic neuropathy, post-remedial neuralgia, and social tension problems. Its fundamental site of activity has all the earmarks of being the α2-δ subunit of the voltage-subordinate calcium channels that are broadly dispersed all through the fringe and focal sensory system. The idea of detailing quick tablets dissolving comprising of PRE delivers a reasonable & commonsense methodology in the wanted goal of quicker crumbling & disintegration at

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Ramana, B. V., C. Triveni, G. Nagarajan, and T. E. G. K. Murthy. "DESIGN DEVELOPMENT AND EVALUATION OF FAST DISSOLVING ORAL FILMS OF RANITIDINE HYDROCHLORIDE." INDIAN DRUGS 51, no. 06 (2014): 27–36. http://dx.doi.org/10.53879/id.51.06.10097.

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The aim of this study was to develop an innovative fast dissolving oral film of Ranitidine HCl based on polymers such as Hydroxy Propyl Methyl Cellulose-E6, Hypromellose-E3 LV, and Polyvinyl alcohol. Trials on various concentrations of polymers were conducted in order to optimize polymer concentration and develop the films with best suitability and acceptability. The various concentrations of super disintegrating agents like Crospovidone, Croscarmellose sodium and Sodium Starch Glycolate were evaluated. The fast dissolving oral films were characterized for weight, thickness, folding endurance,

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Kumar, S., J. V. Kumar, and P. Singhal. "FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF LORATADINE SOLID DISPERSION USING SUPER DISINTEGRANTS." INDIAN DRUGS 56, no. 08 (2019): 84–87. http://dx.doi.org/10.53879/id.56.08.11304.

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The aim of the present investigation was to prepare solid dispersion (SD) of the water insoluble drug. Loratadine using super disintegrants as carrier and formulate it as fast dissolving tablets (FDTs) with an objective to improve solubility and enhance dissolution of drug. The SD’s of the drug were prepared by melt dispersion technique using polyethylene glycol (PEG) 6000 in diferent ratios 1 : 2.5, 1 : 5 and 1 : 7.5. The prepared SD formulations were characterized for equilibrium solubility, Fourier Transform Infrared spectroscopy (FTIR) and in vitro dissolution study. The batch containing S

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Ryakala, Harika, S. Dineshmohan, Alluri Ramesh, and V. R. M. Gupta. "Formulation and In Vitro Evaluation of Bilayer Tablets of Nebivolol Hydrochloride and Nateglinide for the Treatment of Diabetes and Hypertension." Journal of Drug Delivery 2015 (January 14, 2015): 1–14. http://dx.doi.org/10.1155/2015/827859.

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Diabetes mellitus (DM) and hypertension are two common diseases that often coexist. The most common cause of death in the diabetic patient is heart disease. In the present investigation we combine Nebivolol and Nateglinide for better patient compliance. IR layer was formulated using various superdisintegrants like Crospovidone, Croscarmellose sodium, and sodium starch glycolate and SR layer was formulated using polymers and gums like HPMC E15, ethyl cellulose, Gaur gum, and Xanthan gum. The disintegration and dissolution study of both layers showed that inclusion of surfactant (sodium lauryl s

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Sirisha, Yella, Gopala Krishna Murthy T E, and Avanapu Srinivasa Rao. "EFFECT OF FORMULATION FACTORS ON ORODISPERSIBLE TRIPTAN FORMULATIONS – NOVEL APPROACH IN TREATMENT OF MIGRAINE." Asian Journal of Pharmaceutical and Clinical Research 11, no. 3 (2018): 212. http://dx.doi.org/10.22159/ajpcr.2018.v11i3.23401.

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Objective: The present research work is an attempt to determine the effect of various diluents and superdisintegrants on drug release of eletriptan orodispersible tablets and designs an optimized formulation using 22 factorial design. Further, evaluate the tablets for various pre-compression and post-compression parameters.Methods: The drug excipient compatibility study was conducted by infrared spectroscopy, differential scanning colorimetry and X-ray diffraction studies were conducted to test the purity of the drug. The tablets were formulated by direct compression method using spray dried l

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H. Tizkam, Hussam, Alaa A. Abdul Rassol, and Ahmed A. Hussain. "Preparation of a New Dosage Form of Metoclopramide Hydrochloride as Orodispersible Tablet." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 18, no. 1 (2017): 38–48. http://dx.doi.org/10.31351/vol18iss1pp38-48.

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Metoclopramide HCl (MTB) is a potent antiemetic drug used for the treatment of nausea and vomiting. Many trials were made to prepare a satisfactory MTB orodispersible tablet using direct compression method.Various super disintegrants were used in this study which are croscarmellose sodium (CCS), sodium starch glycolate (SSG) and crospovidone (CP). The latter was the best in terms of showing the fastest disintegration time in the mouth.Among the different diluents utilized, it was found that a combination of microcrystalline cellulose PH101 (MCC 101), mannitol, dicalcium phosphate dihydrate (DP

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Fahmansyah, Lingga Pratama, Agus S, and Suparman. "REVIEW : OF SUPERDISINTEGRANT INGREDIENTS IN FAST DISINTEGRANT TABLET TABLET PREPARATIONS." Medical Sains : Jurnal Ilmiah Kefarmasian 9, no. 3 (2024): 857–76. http://dx.doi.org/10.37874/ms.v9i3.1292.

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This study aimed to evaluate the potential of synthetic and natural disintegrating agents in fast-disintegrating tablet (FDT) formulations. The methodology used includes a comprehensive literature review on the definition, characteristics, working mechanisms, and applications of super disintegrants in the manufacture of FDTs. The results of the study showed that super disintegrants play an important role in facilitating rapid disintegration of tablets. Synthetic super disintegrants such as crospovidone, croscarmellose sodium, and sodium starch glycolate have the advantage of lower concentratio

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Gaikwad, Bhavna B., Bhushan R. Rane, and Ashish S. Jain. "Formulation and Evaluation of Orodispersible Tablet of Sulindac." European Journal of Pharmaceutical Research 2, no. 3 (2022): 11–19. http://dx.doi.org/10.24018/ejpharma.2022.2.3.41.

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Oral administration of dosage form is the most recommended mode of administration, because of its self-medication, accurate dose of the drug, and ease of administration. However, trouble swallowing in geriatric patients is one major negative of this route, which can mentally disrupt patients. The goal of this study was to use the direct compression method to make orodispersible tablets of sulindac utilizing various doses of super disintegrant agents such as Sodium starch glycolate Crospovidone and Croscarmellose sodium. Three distinct super disintegrants were used to create nine formulations w

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B, Archana, Abubakar Sadiq, Anitha Mahadev, and Maleka Begum. "Formulation and evaluation of irbesartan fast disintegrating tablets by direct compression technique." International Journal of Clinical Pharmacokinetics and Medical Sciences 3, no. 2 (2023): 72–79. http://dx.doi.org/10.26452/ijcpms.v3i2.530.

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The main objective of the present study is to develop a pharmaceutically stable, cost effective & quality improved robust formulation. The main aim of the present work is to formulate & evaluate Irbesartan fast disintegrating tablets by using pH 6.8 phosphate buffer as a dissolution medium, USP II paddle method. The superdisintegrants sodium starch glycolate, croscarmellose sodium, and crospovidone were used in the current work to generate a total of six distinct formulations employing the direct compression method. Irbesartan, an angiotensin receptor blocker, has a role in the treatme

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Hiremath, S. P., and Chidambar Makanapur. "FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF A MODEL ANTI-HYPERTENSIVE DRUG." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 10 (2017): 34. http://dx.doi.org/10.22159/ijpps.2017v9i11.18967.

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Objective: The rationale of the current work was to formulate and evaluate orodispersible tablets by direct compression technique with a vision to augment patient compliance and rapid onset of action.Methods: Nine orodispersible formulations of propranolol were formulated by direct compression method using sodium starch glycolate, crospovidone and croscarmellose sodium as the super disintegrants. The prepared formulations were evaluated for wetting time, drug content, in vitro disintegration time, dispersion time, dissolution time and also projected to kinetic treatment to know the pattern of

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Ashwini, Warnkar* Dr. M. A. Channawar Dr. A. V. Chandewar Anjali Bhansali Anisha Kohale Gaurav Magar. "Design, Development and In-Vitro Characterization of Rapidly Disintegrating Oral Solid Dosage Form." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4731–49. https://doi.org/10.5281/zenodo.15545054.

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The objective of the present study was to design, develop, and evaluate rapidly disintegrating oral films (RDOFs) of Ketorolac Tromethamine for effective pain management, especially in patients with swallowing difficulties. Oral films offer a convenient and patient-friendly alternative to traditional solid dosage forms due to their rapid disintegration and absorption through the oral mucosa. Ketorolac Tromethamine, a potent non-steroidal anti-inflammatory drug (NSAID), was selected as the active pharmaceutical ingredient due to its rapid onset of action. Various film-forming polymers such as H

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