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Dissertations / Theses on the topic 'Cross-coupling reactions'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Arismendi, Romero Graciela. "Paladium catalized cross-coupling reactions." Revista de Química, 2012. http://repositorio.pucp.edu.pe/index/handle/123456789/101014.

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El premio Nobel en Química de este año ha sido otorgado a los investigadores Richard Heck (EE.UU.), Ei-ichi Negishi (EE.UU.) y Akira Suzuki (Japón), por sus valiosos aportesen el desarrollo de un tipo específico de reacciones para la formación de enlaces C-C: “Reacciones de acoplamientocruzado catalizadas por paladio”. La creciente demanda de nuevas sustancias para el desarrollo de medicamentos, materiales y/o compuestos biológicamente activos ha hecho de este descubrimiento una importante herramienta para los químicos, dándoles la capacidad de atender estas necesidades con la creación de molé

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2

Moriwaki, Yuya. "Cross-Coupling Reactions in Flow Microreactor Systems." 京都大学 (Kyoto University), 2015. http://hdl.handle.net/2433/200446.

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3

Adams, Kirsty. "Metal catalysed cross-coupling reactions of heterocycles." Thesis, University of Huddersfield, 2013. http://eprints.hud.ac.uk/id/eprint/20889/.

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This report describes two methodology studies dedicated towards development of metal catalysed crosscoupling reactions in the synthesis of novel heterocyclic compounds. Firstly, a Heck-Mizoroki arylation reaction is reported for the direct functionalisation of tetrahydropyridines, towards the synthesis of kainoid analogues. Kainoids are a group of non-proteinogenic pyrrolidine dicarboxylic acids, which have attracted considerable interest because of their potent biological activity, including insecticidal, anthelmintic and neuroexcitatory properties. The ideal synthesis of kainoids would allow

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4

Black, Daniel. "Imines in copper-catalyzed cross-coupling reactions." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=102960.

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The purpose of this study was to develop new catalytic methods to mediate carbon-carbon bond forming reactions with imines under mild conditions and in a general manner. We found that copper catalysts were compatible in cross-coupling of a range of mild organometallic reagents, providing simple, efficient routes to alpha-substituted amides and amines.<br>Chapter 2 of this thesis describes a new copper-catalyzed multicomponent synthesis of alpha-substituted amides. This reaction was developed based upon previous work in this laboratory, which showed that palladium catalysts were competent in St

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5

Hall, Mark Andrew. "Iron-catalysed cross-coupling and reduction reactions." Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.551314.

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Iron nanoparticles of size 6-16 nm have been successfully prepared by the reduction of FeCb with 3-pentylmagnesium bromide in the presence of polyethylene glycol. These nanoparticles show excellent activity in the catalytic dehalogenation of a range of alkyl and aryl halides when used at 5 mol% loadings, if an excess of the Grignard is present to ensure the regeneration of the catalyst. Alkyl halides react to give mixtures of alkane, alkene and homocoupled products, with good selectivity of the alkane product being observed. Aryl halides undergo hydrodehalogenation cleanly and do not undergo h

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6

Zhou, Jianrong (Jianrong Steve). "Cross-coupling reactions of unactivated alkyl halides." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/33655.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2005.<br>Vita.<br>Includes bibliographical references.<br>My graduate research at MIT has been focused on the development of palladium- or nickel-catalyzed cross-coupling reactions using unactivated alkyl electrophiles (e.g., halides and sulfonates). Although aryl and alkenyl electrophiles have been commonly used in such processes, the utility of alkyl substrates has been underdeveloped, and merits further exploration. We have developed the first palladium-based catalyst that is effective for Negishi couplings of prima

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7

Hua, Xi Ye. "Expanding the Scope of Coupling Partners in Catalytic Cross-Coupling Reactions." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35521.

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Carbon-carbon (C-C) bond formation is among the most important processes in organic chemistry. Transition metal catalyzed C-C bond formation is an active research area that shows great potential due to high selectivity and relatively mild conditions. In Chapter 1, a new reaction for direct acylation of aryl halides is discussed. Specifically, the catalytic reaction between aryl halides/pseudohalides and aldehydes is explored. The choice of ligand, base, solvent, temperature, catalyst and substrates are important factors for optimizing this catalytic reaction. The various combinations of all

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8

García, Melchor Maximiliano. "Theoretical Study on Pd-catalyzed Cross-Coupling Reactions." Doctoral thesis, Universitat Autònoma de Barcelona, 2012. http://hdl.handle.net/10803/96827.

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D’ençà el seu descobriment, fa ja prop de tres dècades, les reaccions d’acoblament creuat C-C catalitzades per Pd han esdevingut una de les transformacions més poderoses dins la química organometàl·lica. De fet, tres dels desenvolupadors de les reaccions d’acoblament més emprades (reaccions de Heck, Suzuki i Negishi) van ésser guardonats l'any 2010 amb el premi Nobel de Química. El mecanisme general de les reaccions d'acoblament creuat C-C consisteix en tres etapes: addició oxidant, transmetal·lació, i eliminació reductiva. La millora d’una reacció comporta el coneixement profund del seu mecan

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9

Munday, Rachel Hannah. "Vinyldimethylphenylsilanes as latent partners in cross-coupling reactions." Thesis, University of Nottingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430546.

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10

Zhang, Liang. "Catalytic Conjunctive Cross-Coupling and Catalytic Diboration Reactions." Thesis, Boston College, 2017. http://hdl.handle.net/2345/bc-ir:107561.

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Thesis advisor: James P. Morken<br>This dissertation will present four main projects focused on stereoselective construction of borylated compounds as well as their applications in asymmetric syntheses. The first two projects describe the development of a catalytic conjunctive cross-coupling reaction. By merging three simple starting materials, an organolithium reagent, an organoboronate, and an organic electrophile, a synthetically valuable secondary boronate is furnished by the conjunctive cross-coupling in an efficient and enantioselective fashion. Next, this strategy is expanded to synthes

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11

Siddle, James Spencer. "Metal-catalysed cross-coupling reactions of nitrogen heterocycles." Thesis, Durham University, 2010. http://etheses.dur.ac.uk/617/.

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Described herein are copper-catalysed N-C heteroarylations of benzimidazole, 1-methylbenzimidazolone, imidazole and pyrrole. The products of these reactions then undergo palladium-catalysed C-C cross-couplings with aryl or heteroarylboronic acids under Suzuki-Miyaura conditions to provide a rapid entry to tris(hetero)aryl scaffolds comprising two or three N-heterocyclic rings. The sequential N-C and C-C couplings can be performed in a one-pot process. 1,5-Di(hetero)arylated-pyridin-2(1H)-one derivatives have been synthesised in good yields starting from (2-fluoro-5-pyridyl)boronic acid. The se

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12

Parry, Paul Richard. "New pyridylboronic acids and their cross-coupling reactions." Thesis, Durham University, 2003. http://etheses.dur.ac.uk/3705/.

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The novel substituted pyridylboronic acids 2-bromo-5-pyridylboronic acid 92, 3-hromo-5- pyridylboronic acid 97, 2-chloro-5-pyridylboronic acid 103, 2-fluoro-5- pyridylboronic acid 108, 2-methoxy-5-pyridylboronic acid 123, 2-ethoxy-5- pyridylboronic acid 125, 2-medioxy-3-pyridylboronic acid 131, 3-bromo-6-methoxy-4- pyridylboronic acid 134, 3-chloro-6-methoxy-4-pyridylboronic acid 137 and 3-hromo-6- ethoxy-4-pyridylboronic acid 138 have been synthesised and shown to undergo palladium-catalysed Suzuki cross-coupling reactions with a vast variety of heteroaryl bromides to yield novel heteroarylpy

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13

Pye, Dominic Richard. "Improved and new iron-catalysed cross-coupling reactions." Thesis, University of Bristol, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.687060.

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Iron-catalysed cross-coupling chemistry is undergoing a renaissance due advantages in cost, toxicity and abundance compared to traditional cross-coupling catalysts. In Chapter 2 it is shown that expensive, synthetically challenging bis-phosphines used in the iron-catalysed cross-coupling of alkyl halides and arylboronic acid pinacol esters can be replaced in many cases with simple iron salts in phosphine-free procedures. More challenging substrates require the use of cheap, widely available bis-phosphines such as dppe (l,2-bis(diphenylphosphino)ethane) or dppp (1,3- bis(diphenylphosphino)propa

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14

Masson-Makdissi, Jeanne. "Controlling Selectivity in Cross-Coupling Reactions with Ester Electrophiles." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/38398.

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First popularized in the 1970s, transition metal-catalyzed cross-couplings now constitute staple reactions for the formation of carbon-carbon and carbon-heteroatom bonds. Recent endeavours in the field have been invested towards expanding the range of compatible coupling partners, with the aim of accessing complex molecules from simple, widely available starting materials. Notably, esters represent an attractive class of alternative coupling partners compared to traditional aryl halides, due to their ubiquity and robustness. Moreover, different cleavage modes can be accessed with esters. Which

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15

Woods, Tom MacDonald. "Phosphinates as new electrophilic reagents for cross-coupling reactions." Thesis, Durham University, 2008. http://etheses.dur.ac.uk/2130/.

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Activated esters, e.g. triflates, sulfonates, nonaflates and phosphates are excellent electrophiles for a variety of cross-coupling reactions. However, other phosphorus-based esters have received little attention in these protocols. This thesis discusses the synthesis and cross-coupling chemistry of vinyl phosphinates, a new class of electrophilic species. A simple model vinyl phosphinate, N-(tert-butyloxycarbonyl)-4,5,6,7-tetrahydro-1H-azepin-2-yl-diphenylphosphinate, was prepared in excellent yield from commercially available caprolactam. A screening study identified Suzuki cross-coupling co

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16

Ellis, Peter J. "Mechanistic studies of cross-coupling reactions using Pd nanoparticles." Thesis, University of York, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.516508.

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17

Nunn, Joshua. "Insights into cross-coupling reactions using cheaper metal catalysts." Thesis, University of Bristol, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.687059.

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The mechanisms of a range of cross-coupling reactions catalysed by cheaper metal catalysts have been investigated in detail using a combination of spectroscopic techniques and computational modelling. For iron-catalysed Negishi cross-coupling reactions supported by phosphine ligands, it is shown that the iron(II) pre-catalysts are reduced in situ to iron(I), which is found to be the only kinetically relevant oxidation state. The characterisation of a range of relevant low-spin iron(l) phosphine complexes has allowed the study of the mechanism in significantly greater detail than before via dir

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18

Ben, Halima Taoufik. "Engaging Esters as Cross-Coupling Electrophiles." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39493.

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Cross-coupling reactions, where a transition metal catalyst facilitates the formation of a new carbon-carbon or carbon-heteroatom bond between two coupling partners, has become one of the most widely used, reliable, and robust family of transformations for the construction of molecules. The Nobel Prize was awarded to pioneers in this field who primarily used aryl iodides, bromides, and triflates as electrophilic coupling partners. The expansion of the reaction scope to non-traditional electrophiles is an ongoing challenge to enable an even greater number of useful products to be made from simp

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19

Kienle, Marcel. "Oxidative and Transition-Metal Catalyzed Cross-Coupling Reactions, Preparation and Coupling of S-Heterocycles." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-113699.

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20

Sun, Shangzheng. "Building up molecular complexity by Ni-catalyzed cross-coupling reactions." Doctoral thesis, Universitat Rovira i Virgili, 2020. http://hdl.handle.net/10803/670603.

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En línia amb la investigació desenvolupada al nostre grup basada en l’elaboració de noves reaccions d’acoblament creuat, hem decidit centrar la tesis doctoral en l’estudi de la formació de nous enllaços Csp3–Csp3, utilitzant reaccions d’acoblament creuat reductores catalitzades per níquel. Al primer capítol, els nostres esforços es centren en la preparació d’una nova metodologia basada en l’alquilació reductiva de a-haloboronats, utilitzant com a matèria prima olefines no activades. Aquest nou protocol, quimio- i regioselectiu, permet l’incorporació d’un fragment alquílic-boronat a olefin

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21

Jensen, Anne Eeg. "Transition metal-catalyzed cross-coupling reactions of functionalized organometallic reagents." Diss., lmu, 2001. http://nbn-resolving.de/urn:nbn:de:bvb:19-2331.

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22

Hammann, Jeffrey [Verfasser], and Paul [Akademischer Betreuer] Knochel. "Cobalt-catalyzed cross-coupling reactions / Jeffrey Hammann ; Betreuer: Paul Knochel." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1130587401/34.

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23

Andrews, Philip Ian. "New organometallic strategies for conjugate addition and cross-coupling reactions." Thesis, University of Nottingham, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.606337.

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Enamine N-oxides have been reported only a very few times in the literature. Investigation into their reactivity has revealed that treatment with catecholborane can generate amines via an electrophilic iminium species, which provides evidence for a proposed reverse polarity reactivity, with respect to existing l,4-additions to nitro alkenes. Deprotonation at the a-carbon of enamine N-oxide double bonds has also been accomplished by 'BuLi, with deprotonation occurring fully after 5 min. Using methodology developed within the group, a novel enamine N-oxide has been synthesised in good yield, alt

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24

O'Brien, Harry. "Advances in iron-catalysed cross-coupling reactions : methodology and mechanism." Thesis, University of Bristol, 2018. http://hdl.handle.net/1983/84e24322-d526-4169-9ed4-e7a2fb2d710a.

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The replacement of noble metals with cheap, sustainable and non-toxic iron as catalysts for cross coupling reactions continues unabated. The significant advancement in methodology has been accompanied by elegant mechanistic studies; vital for further reaction development. Amongst this success, the development of reactions which work with milder coupling partners is paramount. Organoboron reagents are particularly useful, and accordingly there has been great progress in the development of iron-catalysed Suzuki cross-coupling reactions. However, the cross-coupling between an aryl halide and aryl

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25

Ruiz-Castillo, Paula. "Palladium-catalyzed C-N and C-O cross-coupling reactions." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/105048.

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Thesis: Ph. D. in Organic Chemistry, Massachusetts Institute of Technology, Department of Chemistry, 2016.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 375-410).<br>Chapter 1: This chapter describes a general method for the of the Pd-catalyzed N-arylation of hindered [alpha],[alpha],[alpha]-trisubstituted primary amines. The reaction utilized catalysts based on two biaryl phosphine ligands, which were developed via kinetics-based mechanistic analysis and rational design. These studies led to the first example of catalyst based on a hybrid (alkyl)aryl b

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26

Chae, Junghyun 1973. "Development and application of transition metal-catalyzed cross-coupling reactions." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/17735.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2004.<br>Includes bibliographical references.<br>Chapter 1. PALLADIUM-CATALYZED REGIOSELECTIVE HYDRODEBROMINATION OF DIBROMOINDOLES A novel approach to the selective preparation of 4-bromoindoles has been developed via a Pd-catalyzed reaction. A variety of 4,6-dibromoindoles, which are prepared via Cu-catalyzed chemoselective C-N bond-forming reaction and subsequent Fischer indole cyclization, are transformed to 4-bromoindoles with high regioselectivity using a catalytic Pd(OAc)2/rac-BINAP system. This new method allow

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Sherborne, Grant John. "Catalyst deactivation in copper-catalysed C-N cross-coupling reactions." Thesis, University of Leeds, 2017. http://etheses.whiterose.ac.uk/17595/.

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This thesis details research into the mechanism of the copper-catalysed cross-coupling reaction, with a focus on the N-arylation of secondary amines and amides (Ullmann-Goldberg reaction). Issues limiting the application of the Ullmann-Goldberg reaction on industrial scale are uncovered and understood from a mechanistic point of view, to provide a platform for more efficient copper catalysts. In situ kinetic monitoring using 1H NMR spectroscopy is used to understand the role of each key component in the N-arylation of piperidine using a copper catalyst in a fully homogeneous system. Key roles

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28

Sharma, Mahima. "Design of artificial metalloenzymes for C-C cross-coupling reactions." Thesis, University of Oxford, 2014. https://ora.ox.ac.uk/objects/uuid:8756ddda-60b7-45a6-9590-56eabf11f260.

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Artificial metalloenzymes enable several non-natural chemical transformations by hosting a metal catalyst and providing activating microenvironments to the metal. New strategies to combine the complementary features of enzyme and transition metal catalysis are crucial for exploiting the pre-evolved selectivities of enzymes in chemical synthesis. In order to exploit the inherent selectivity of a serine protease Subtilisin (SBL) for C-C crosscoupling reactions, the interplay of natural substrate binding pockets and the nucleophilic machinery of the enzyme with the metal catalyst was central to o

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29

Lima, Fabio. "Photoredox C-C cross-coupling reactions using boronic acid derivatives." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/274928.

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In recent years, photoredox catalysis emerged as a privileged tool for small molecules activation via single-electron transfer mechanisms. Despite their ubiquity as reagents in organic synthesis, the use of boronic acid derivatives to generate carbon-centred radicals remains elusive. This dissertation explores the utilisation of photoredox catalysis to generate carbon radicals from boronic acid derivatives and subsequently engage them in C–C cross-coupling reactions. In the first chapter, an introduction to photoredox catalysis and organoboron reagents is provided, as well as a discussion on t

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30

Dunet, Guillaume. "Preparation and Reactions of Allylic Zinc Reagents and Transition Metal-Catalyzed Cross-Coupling Reactions." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-78249.

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31

Blaisdell, Thomas Powers. "New Strategies for Hydroxyl-Directed Organic Reactions." Thesis, Boston College, 2015. http://hdl.handle.net/2345/bc-ir:104626.

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Thesis advisor: Kian L. Tan<br>Thesis advisor: James P. Morken<br>Described herein are four different research projects spanning over two different research groups. The first two projects describe the development and application of scaffolding catalysts for the (1) site-selective silylation of ribonucleosides and (2) the distal and diastereoselective hydroformylation of homoallylic alcohols. These projects emphasize the effectiveness of scaffolding catalysts to bind a hydroxyl-containing substrate and control the site- or regioselectivity of a reaction using said substrate. The third project d

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32

Serra, Parareda Jordi. "Gold complexes for homogeneous cross-coupling catalysis and migratory insertion reactions." Doctoral thesis, Universitat de Girona, 2018. http://hdl.handle.net/10803/664428.

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Most of the different homogeneous reactions catalyzed by gold have been developed in the past fifteen years and stem from the ability of both Au(I) and Au(III) complexes to coordinate and activate multiple carbon-carbon bonds. However, the high ionization potential of gold has long hindered Au(I)/Au(III) catalytic cycles under homogeneous conditions, an underdeveloped field compared to classical cross-coupling methodologies. Although direct evidence for the main elementary steps of organometallic chemistry has been obtained very recently, their scope is still limited and much remains to be don

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33

Yin, Lunxiang. "Synthesis of new calcineurin inhibitors via Pd-catalyzed cross coupling reactions." Doctoral thesis, [S.l. : s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=975817868.

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34

Marziale, Alexander [Verfasser]. "Palladium complexes for cross-coupling reactions in aqueous media / Alexander Marziale." München : Verlag Dr. Hut, 2011. http://d-nb.info/1013526619/34.

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35

Muñoz, Torres David [Verfasser]. "Molecular Rods and Stars through Cross-Coupling Reactions / David Muñoz Torres." München : Verlag Dr. Hut, 2013. http://d-nb.info/1037287061/34.

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36

Dahadha, Adnan [Verfasser], Wolfgang [Akademischer Betreuer] Imhof, and Matthias [Akademischer Betreuer] Westerhausen. "Catalytic cross coupling reactions / Adnan Dahadha. Gutachter: Wolfgang Imhof ; Matthias Westerhausen." Jena : Thüringer Universitäts- und Landesbibliothek Jena, 2012. http://d-nb.info/1024080420/34.

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Smith, Paul James. "Palladium catalysed Suzuki cross-coupling reactions in ambient temperature ionic liquids." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405785.

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Gallop, Christopher W. D. "N-heterocyclic carbene-palladium and -copper complexes in cross-coupling reactions." Thesis, University of Sussex, 2015. http://sro.sussex.ac.uk/id/eprint/54338/.

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Chapter 1 gives the reader a background on cross-coupling reactions, in particular palladium mediated couplings. Furthermore the importance of ligands, including phosphines and N-heterocyclic carbenes (NHC), in such cross-coupling reactions is explored. Chapter 2 provides a background to the reductive lithiation of phosphines, followed by an account of our investigation of BINAP functionalisation by means of reductive elimination.1 The reaction was examined by experimental means and through the use of density functional theory to predict 31P NMR chemical shifts. Chapter 3 provides background o

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39

Bae, Jin-Young. "Aryl mesylates in nickel (0) catalyzed homo- and cross coupling reactions." Case Western Reserve University School of Graduate Studies / OhioLINK, 1995. http://rave.ohiolink.edu/etdc/view?acc_num=case1058375395.

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40

Marset, Xavier. "Deep Eutectic Solvents: À la Carte Solvents for Cross-Coupling Reactions." Doctoral thesis, Universidad de Alicante, 2019. http://hdl.handle.net/10045/95790.

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En la presente memoria se describe el uso de líquidos eutécticos sostenibles (DESs en inglés) como medios de reacción, empleando diferentes catalizadores metálicos para llevar a cabo la síntesis de compuestos orgánicos de interés en química orgánica. En el Primer Capítulo se detalla el uso de un catalizador heterogéneo de cobre soportado sobre magnetita en el acoplamiento cruzado deshidrogenante de tetrahidroisoquinolinas en mezclas eutécticas. En el Segundo Capítulo se pormenoriza sobre la síntesis de un complejo tipo pinza de paladio y su empleo en la reacción de acoplamiento

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41

Chamoin, Sylvie. "Aryl-aryl Stille and Suzuzi-Miyaura cross-coupling reactions on solid support." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0022/NQ51184.pdf.

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42

Teverovskiy, Georgiy. "Development of novel transition metal-catalyzed cross-coupling reactions and applications thereof." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/82322.

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Thesis (Ph. D. in Organic Chemistry)--Massachusetts Institute of Technology, Dept. of Chemistry, 2013.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Chapter 1 The first example of Pd(0)/(II) catalyzed fluorination of aryl bromides is reported herein. Based on these data, an analogous method was developed for the fluorination of aryl triflates. The reaction proceeds under mild conditions and represents the first report of reductive elimination from a Pd(II) center of a C-F bond. Chapter 2 Herein we report the first example of a Pd-catalyzed synthesis of ary

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Fors, Brett P. "Development and Applications of Pd Catalysts for C-N Cross-Coupling Reactions." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/65265.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2011.<br>Vita. Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Chapter 1 A procedure for forming a highly active Pd(0) catalyst from Pd(OAc) 2, water, and biarylphosphine ligands has been developed. This protocol generates a catalyst system, which exhibits excellent reactivity and efficiency in the coupling of a variety of amides and anilines with aryl chlorides. Chapter 2 A new class of one-component Pd precatalysts bearing biarylphosphine ligands is described. These precatalysts are a

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Yang, Yuan. "Graphene as a Solid-state Ligand for Palladium Catalyzed Cross-coupling Reactions." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5488.

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Palladium-catalyzed carbon-carbon cross-coupling reactions have emerged a broadly useful, selective and widely applicable method to synthesize pharmaceutical active ingredients. As currently practiced in the pharmaceutical industry, homogeneous Pd catalysts are typically used in cross-coupling reactions. The rational development of heterogeneous catalysts for cross-coupling reactions is critical for overcoming the major drawbacks of homogeneous catalysis including difficulties in the separation, purification, and quality control process in drug production. In order to apply heterogeneous catal

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Agata, Ryosuke. "Development of Iron-Catalyzed Selective Cross-Coupling Reactions toward Natural Product Synthesis." Kyoto University, 2019. http://hdl.handle.net/2433/242522.

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Brinkley, Kendra W. "The Synthesis of Solid Supported Palladium Nanoparticles: Effective Catalysts for Batch and Continuous Cross Coupling Reactions." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3959.

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Catalysis is one of the pillars of the chemical industry. While the use of catalyst is typically recognized in the automobile industry, their impact is more widespread as; catalysts are used in the synthesis of 80% of the US commercial chemicals. Despite the improved selectivity provided by catalyst, process inefficiencies still threaten the sustainability of a number of synthesis methods, especially in the pharmaceutical industry. Recyclable solid supported catalysts offer a unique opportunity to address these inefficiencies. Such systems coupled with continuous synthesis techniques, have the

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Lakó, Ágnes. "Towards Nickel Boride Catalyzed C-C Coupling Reactions." Thesis, KTH, Skolan för kemivetenskap (CHE), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-216398.

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This thesis focuses on the study of nickel boride as a catalyst in various coupling reactions. The nickel boride catalyst was investigated in three different coupling reactions, the experiments aimed at understanding the activity and catalytic properties of nickel boride. We successfully synthetized the nickel boride catalyst, alongside with the cobalt and iron boride. Different methods of preparation were compared and we concluded, that the differences in the preparation, such as solvent and atmosphere, influence the activity of the catalyst in coupling reactions. We found that the most suita

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Livendahl, Madeleine. "Mechanistic studies on gold mediated cross-coupling reactions and total synthesis of (_+ )-epiglobulol." Doctoral thesis, Universitat Rovira i Virgili, 2013. http://hdl.handle.net/10803/126532.

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Tras la activación con complejos catiónicos de oro(I), los 1,6-eninos conteniendo alcoholes o éteres se pueden atrapar intra- o intermolecularmente con alquenos o éteres bencílicos. Esta reacción estereospecífica da lugar a compuestos tricíclicos relacionados con los sesquiterpenos 4-epiglobulol y 4-aromadendreno. La síntesis racémica del 4-epiglobulol se comenzó a partir del geranyl acetona que es comercial. Hemos cumplido la síntesis total del producto natural (±)-epiglobulol en 5 pasos con un rendimiento total de 16%.Hemos investigado el acoplamiento C-C mediado por oro, mostrando que en

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Karabiyikoglu, Sedef. "Synthesis Of Ferrocenyl Substituted Pyrazoles By Sonogashira And Suzuki-miyaura Cross-coupling Reactions." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/3/12612139/index.pdf.

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Pyrazoles constitute one of the most important classes of heterocyclic compounds due to their interesting chemical and biochemical features. Researchers have studied many pyrazole containing structures for almost over a century in order to investigate the various biological activities possessed by these molecules. A new and important trend in these studies is to produce ferrocenyl substituted pyrazoles since ferrocene attracts considerable interest in the research field of organometallic and bioorganometallic chemistry because of its valuable chemical characteristics like high stability, low t

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Leslie, Wendy. "Cross-coupling reactions in the development of new luminescent iridium bis-terpyridyl complexes." Thesis, Durham University, 2003. http://etheses.dur.ac.uk/3736/.

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Luminescent complexes of 2(^nd) and 3(^rd) row transition metal ions with polypyridyl ligands are of growing interest as molecular luminescent sensors. The long luminescence lifetime of iridium (III) bis-terpyridine, [Ir(tpy)(_2)](^3+), makes it and its derivatives of particular interest, but the further development of such compounds requires improved synthetic routes as well as a greater understanding of their photophysical properties. The palladium-catalysed Suzuki cross-coupling methodology has been investigated as a means for the preparation of 4'-aryl and biaryl substituted 2, 2': 6', 2"-

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