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Journal articles on the topic 'Cross Croscamellose Sodium And Sodium Starch Glycolate'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Putra, Okta Nama, Ida Musfiroh, Sarah Elisa, et al. "Sodium Starch Glycolate (SSG) from Sago Starch (Metroxylon sago) as a Superdisintegrant: Synthesis and Characterization." Molecules 29, no. 1 (2023): 151. http://dx.doi.org/10.3390/molecules29010151.

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The characteristics of sago starch exhibit remarkable resemblances to those of cassava, potato, and maize starches. This review intends to discuss and summarize the synthesis and characterization of sodium starch glycolate (SSG) from sago starch as a superdisintegrant from published journals using keywords in PubMed, Scopus, and ScienceDirect databases by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020). There are many methods for synthesizing sodium starch glycolate (SSG). Other methods may include the aqueous, extrusion, organic solvent slurry, and dry methods

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2

Shahidulla, SM, and Tayyaba Jeelani. "Formulation and In-Vitro Evaluation of Taste Masked Fast Disintegrating Tablets of Labetalol Hydrochloride by Wet Granulation Technique." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 442–49. http://dx.doi.org/10.22270/jddt.v9i4-a.3506.

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Labetalol Hydrochloride is a β-blocker generally indicated for the treatment of hypertension, and it is extensively metabolized due to the hepatic metabolism. In the present work, an attempt was made to mask the taste by Solid Dispersion technique, with a formulation into Fast Disintegrating dosage form, using superdisintegrants such as Cross carmellose sodium (CCS), crospovidone (CP) and sodium starch glycolate (SSG). The complexes of Labetalol hydrochloride with HP-β-CD (1:3 ratio) were prepared by Co-precipitation method. Using the drug HP-β-CD complex, Fast Disintegrating tablets were prep

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3

K., Ramanji Reddy* Dr.Chandaka Madhu Dr. Mohammed Omar Sachin Vanji Ahirrao P.Jhansi Lakshmi. "FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF FEXOFENADINE HYDROCHLORIDE." Indo American Journal of Pharmaceutical Sciences 04, no. 09 (2017): 3230–42. https://doi.org/10.5281/zenodo.967492.

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In the present work, mouth dissolving tablets of fexofenadine HCl were designed with a view to enhance patient compliance by direct compression method. The present work studied the effect of superdisintegrants on release rate of fexofenadine HCl in the form of fast disintegrating tablet. For the present study range of superdisintegrants in their different concentrations, were used. The superdisintegrants used were Magnesium stearate, Microcrystalline Cellulose, Cross Povidone, Sodium Starch Glycolate,and Cross Carmellose Sodium. The blends were prepared by direct compression technique. The tab

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Nitalikar, Manoj M., and Dinesh M. Sakarkar. "Formulation development and characterization of fast disintegrating tablets of Nimesulide." Stamford Journal of Pharmaceutical Sciences 4, no. 2 (2012): 25–28. http://dx.doi.org/10.3329/sjps.v4i2.10436.

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An attempt was made to prepare fast dissolving tablets of anti-inflammatory drug Nimesulide preparing by direct compression method. The superdisintegrants Cross-carmellose and Sodium starch glycolate were used in different concentrations. Twelve formulations using those superdisintegrants at different concentration levels were prepared to access their efficiency and critical concentration level. Different evaluation parameters for tablet were studied. Tablets containing Cross-carmellose showed superior organoleptic properties and excellent in-vitro drug release as compared to other formulation

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5

Mengesha, Yohannes, Anteneh Belete, and Tsige Gebre-Mariam. "Preparation and Characterization of Carboxymethylated and Cross-Linked Enset Starch as a Disintegrant in Tablets." Ethiopian Pharmaceutical Journal 35, no. 2 (2020): 119–34. http://dx.doi.org/10.4314/epj.v35i2.5.

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Starch and modified starches have been commonly employed as excipient in pharmaceutical industry. The use of non-modified or “native” starch, However, is mostly confined due to limitation in several physicochemical properties. Cross-linked sodium carboxymethyl starch which is also known as sodium starch glycolate is extensively used in fast dissolving tablets to disperse the drugs within short span of time. In this study, enset starch was carboxymethylated and subsequently cross-linked. Carboxymethyl enset starch (CMES) was obtained by reacting enset starch and monochloroacetic acid (MCA) in t

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6

Polishetty, Saipriya* Mariyam Suryaprakash Reddy SK. Irfan Khan Afshan Urooj Dr. Y. Krishna Reddy Dr.K. N. V. Rao Dr. K. Rajeswar Dutt. "FORMULATION, OPTIMIZATION AND EVALUATION OF ESLICARBAZEPINE ACETATE." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 03 (2018): 1688–93. https://doi.org/10.5281/zenodo.1209355.

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The present study aims at developing an Eslicarbazepine fast dissolving tablet formulation for the effctive treatment of Epilepsy. To provide the patient with the most convenient mode of administration, FDT’s will dissolve quickly. A Eslicarbazepine is absorbed to atleast 90% from the gut, independently of food intake. It is quickly metabolized to esclicarbazepine. So the present work was aimed at formulating fast dissolving tablet for Eslicarbazepine, total 6 formulations were developed by using synthetic superdisintigrants like cross caramellose sodium, Crosspovidone, sodium starch gly

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Kadu, B. M., S. Bhasme, R. D. Bawankar, and D. R. Mundhada. "Formulation and Evaluation of Rapimelt Tablet of Anti-Vertigo Drug (Lorazepam)." International Journal of PharmTech Research 13, no. 4 (2020): 341–49. http://dx.doi.org/10.20902/ijptr.2019.130405.

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A. Rapimelt tablet of Lorazepam was prepared by direct compression method using Indion 414, Cross Carmellose Sodium and sodium starch glycolate as superdisintegrants with aim to get rapid onset of action, improve bioavailability and to give pleasant taste and better mouth feel. The tablets prepared were evaluated for various parameters like various density parameters, thickness, hardness, friability, disintegration time, wetting time and invitro dissolution time and were found to be within limits as per Indian Pharmacopoeia. FT-IR spectra of physical mixture of Lorazepam with Indion 414showedr

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8

Y., Shiva Kumar* Dr.T. Mangilal Dr. M. Ravi Kumar J. Naveen. "PREPARATION AND EVALUATION OF TAPENTADOL MOUTH DISSOLVING TABLETS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 04 (2019): 8726–36. https://doi.org/10.5281/zenodo.2656643.

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<em>Mouth dissolving tablets are solid dosage forms containing tapentadol as active pharmaceutical ingredient which has analgesic effect, and has superdistegrants like croscarmellose sodium and starch glycolate which disintegrates fast usually less than 60 seconds without the need of water when placed on the tongue. To prepare and evaluate tapentadol mouth dissolving tablet by using direct compression method  and to determine the effect of formulation process and the excipients. Tapentadol MDT were formulated by using ingredients and superdisintegrants like sodium starch glycolate and cro

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Mane, Swapna, Ritesh Bathe, and Sandhyarani Awatade. "Formulation and Evaluation of Fast Disintegrating Tablets of Atenolol Using Natural and Synthetic Superdisintegrants." Journal of Drug Delivery and Therapeutics 9, no. 2-s (2019): 150–58. http://dx.doi.org/10.22270/jddt.v9i2-s.2476.

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Oral disintegrating tablet (ODT) is defined as “A solid dosage form containing medical substances or active ingredient which disintegrates rapidly usually within a matter of seconds when placed upon the tongue”. The aim of the present research is to formulate Atenolol fast disintegrating tablets. Atenolol is β1- cardio selective adrenergic receptor blocker, widely used in the treatment of hypertension, angina pectoris, arrhythmias and myocardial infarction. It works by slowing down the heart and reducing the work load of the heart. The conventional tablets of atenolol are reported to exhibit f

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10

Sharma, Mahavir K., Rupa Singh, Tejas K. Patel, Bhavik Jani, and Dhairyashri Kher. "Formulation and Evaluation of Mouth Dissolving Tablet of Biperiden HCL for Treatments of Parkinson’s Disease." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 04 (2023): 1533–37. http://dx.doi.org/10.25258/ijddt.13.4.63.

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Seven formulations were developed using superdisintegrating substances like sodium starch glycolate, crospovidone, and cross-carmellose sodium at different concentrations. Three batches were created by employing varying concentrations of the super disintegration approach, utilizing sodium starch glycolate as the superdisintegrating agent. The batches underwent evaluation regarding sensory characteristics, firmness, breakability, weight consistency, disintegration time in a simulated environment, time is taken for wetting, laboratory tests on drug release within a controlled environment, and as

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11

Ahmed, Shahriar, Mehrina Nazmi, Ikramul Hasan, Sabiha Sultana, Shimul Haldar, and Md Selim Reza. "Fexofenadine HCl Immediate Release Tablets: In vitro Characterization and Evaluation of Excipients." Bangladesh Pharmaceutical Journal 16, no. 1 (2013): 1–9. http://dx.doi.org/10.3329/bpj.v16i1.14483.

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Fexofenadine HCl immediate release tablets were designed to increase the dissolution rate by using superdisintegrants. Different formulations of Fexofenadine HCl were prepared by direct compression method. These formulations were evaluated for hardness, thickness, friability, weight variation, disintegration time, and in vitro dissolution study. The drug release from the formulations were studied according to USP specification (USP paddle method at 50 rpm for 60 minutes) maintaining the temperature to 37°C. Sodium starch glycolate, cross carmellose sodium, crospovidone (kollidon CL), ludiflash

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12

Jain, P., A. Mishra, and A. Pathak. "PREPARATION & EVALUATION OF ORODISPERSIBLE TABLET CONTAINING ASPIRIN BY SUBLIMATION METHOD." INDIAN DRUGS 52, no. 12 (2015): 60–62. http://dx.doi.org/10.53879/id.52.12.10465.

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Orodispersible tablets are uncoated tablets which when taken into the mouth, get easily dispersed within 3 min before swallowing. they are also known as orally disintegrating tablets, mouth-dissolving tablets, rapid dissolving tablets fast-disintegrating tablets, fast-dissolving tablets. In this work, sublimation process was used to prepare orodispersible tablets of aspirin by formulating various batches using different concentration of sodium starch glycolate, camphor and cross povidone. An effort was made by using two modes, first, to increase water uptake for the fast dispersion by creating

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13

Lakshmi, P. K., D. Lavanya, and M. M. Husnien Ali. "Effect of synthetic super disintegrants and natural polymers in the preparation of donepezil hydrochloride fast disintegration films." International Current Pharmaceutical Journal 3, no. 3 (2014): 243–46. http://dx.doi.org/10.3329/icpj.v3i3.17892.

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The main aim of the present research was to develop a fast dissolving oral polymeric film with good mechanical properties, faster disintegration and dissolution when placed on tongue. Donepezil hydrochloride (DPH) is prescribed in the treatment of mild to moderate Alzheimers disease (AD). The polymers selected for preparing films were sodium alginate (SA), poly vinyl alcohol (PVA) and guar gum (GG). Three batches of films were prepared by solvent casting method with sodium alginate, sodium alginate & PVA and with the combination of sodium alginate & guar gum. From these three batches,

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14

Nandi, U., M. Dahiya, A. Prakash, R. Kumar, and G. N. Singh. "COMPATIBILITY STUDY OF ALOGLIPTIN BENZOATE WITH WIDELY USED PHARMACEUTICAL EXCIPIENTS FOR SOLID DOSAGE FORM." INDIAN DRUGS 55, no. 02 (2018): 20–26. http://dx.doi.org/10.53879/id.55.02.10907.

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Alogliptin is a new dipeptidyl peptidase-4 (DPP-4) inhibitor for oral diabetes care. The present study aims to evaluate the compatibility of alogliptin benzoate with the extensively used pharmaceutical excipients for solid dosage form. This can be achieved by applying Differential Scanning Calorimetry (DSC) and Thermal Gravimetric Analysis (TGA) techniques together with Fourier-Transform Infrared spectroscopy (FT-IR) as paired technique to aid in the interpretation of outcome. Chosen excipients were Cross carmellose sodium, microcrystalline cellulose, magnesium stearate, sodium starch glycolat

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15

Prasad, Garrepally. "Formulation and In Vitro Evaluation of Fast Dissolving Tablets for Albendazole." Journal of Clinical and Medical Case Reports and Reviews 1, no. 1 (2021): 1–3. http://dx.doi.org/10.59468/2837-469x/003.

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The present work is to study the effect of various superdisintegrants on drug (Albendazole) by direct compression methods. The tablets were prepared by four super disintegrants, e.g; sodium starch glycolate, cross carmellose, cross povidone and L- subsituated hydroxyl propyl cellulose. The blend was examined for angle of repose, bulk density, tapped density, compressibility index, and hausner ratio. The tablets were evaluated for hardness, drug content and friability were found satisfactory. Albendazole is a bitter in taste. To prevent bitter taste of the drug formulated with a sweetener (Aspa

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16

Sunand, K., V. Sandhya, A. Swapna, K. Prasanth, A. Vijaya, and J. Geetha. "Formulation Design and in Vitro Evaluation of Oral Disintegrating Tablets of Selegiline." INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH 2, no. 04 (2017): 107–13. http://dx.doi.org/10.21477/ijapsr.v2i04.9603.

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In the present work, an attempt has been made to develop fast disintegrating tablets of Selegiline, were as sodium starch glycolate, cross povidone and cross carmellose sodium were employed as super disintegrating agents to enhance the solubility and dissolution rate of drug molecule. Formulations were prepared by direct compression method using 6mm punch on 8 station rotary tablet punching machine. The blend of all the formulations showed good flow properties such as angle of repose, bulk density and tapped density. The prepared tablets have shown good post compression parameters and they pas

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Kute, S. Shivaji*1 Sonwane Sonali S*2 Jadhav Vaibhav A2. "Super Disintegrants: An Overview." International Journal in Pharmaceutical Sciences 2, no. 1 (2024): 77–89. https://doi.org/10.5281/zenodo.10464297.

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Disintegrants play a crucial role as excipients in solid oral formulations. In immediate release and oral dispersible tablet formulations, super disintegrants like croscarmellose sodium, sodium starch glycolate, crospovidone, and polacrilin potassium are added in small quantities to counteract the effects of compression and binder after administration. The hygroscopic nature of these super disintegrants facilitates the penetration of water into the tablet matrix, while their cross-linkage reduces solubility in water. This article provides an overview of various factors that can influence the f

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18

Rathore, Divya, Vikas Jain, and Narendra Gehlod. "FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF ACECLOFENAC USING NATURAL SUPERDISINTEGRANT." International Journal of Pharmaceutical Sciences and Medicine 7, no. 10 (2022): 39–64. http://dx.doi.org/10.47760/ijpsm.2022.v07i10.004.

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On contact with saliva, FDTs (Fast dissolving tablets) which are designed to disintegrate rapidly, enables tremendous oral administration without contact with water. Also chewing these formulations produces an increased convenience and ease of administration with a significant potential efficacy to improve the patient compliance, predominantly in certain populations who were facing difficulties for swallowing the conventional solid oral dosage forms. In our present study, the effect of a natural superdisintegrant namely, Fenugreek and some synthetic superdisintegrants such as SSG (Sodium Starc

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Mr.A.Anka, Rao* B. Ramya M.V.L.Bhavani P.Ramesh A.Praveen Kumar V.Vasu Naik Dr. A.Seetha Devi. "FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF METOPROLOL SUCCINATE." iajps,csk publications 04, no. 04 (2017): 866–71. https://doi.org/10.5281/zenodo.556113.

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In the present work efforts have been made to develop fast dissolving tablets of Metoprolol succinate using direct compression technique involving super disintegrants like cross povidone, sodium starch glycolate. The pre compression parameters like angle of repose, bulk density, true density, compressibility index are within the IP limit. The post compression parameters are acceptable and within the IP limit. In-vitro drug release at for all the formulations was found to be 95 to 99% and was satisfactory. The optimized formulation (F6,10%cross povidone) of drug release was found to be is 99% a

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Siddheshwar, Suhas Shivaji, Asmita Bhausaheb Ghorpade, Someshwar Dattatraya Mankar, and Santosh Bhausaheb Dighe. "Formulation and Drug Release Study of Rivaroxaban Oral Disintegrating Tablets Using Various Super-Disintegrants." International Journal of Experimental Research and Review 36 (December 30, 2023): 147–55. http://dx.doi.org/10.52756/ijerr.2023.v36.014.

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This study aims to improve Rivaroxaban's solubility, dissolution, and bioavailability. Orally disintegrating tablets (ODTs) made with super-disintegrants like crospovidone, sodium starch glycolate, and cross-carmellose sodium will do this. Tablet preparation used direct compression and formulation optimization with design expert software. After a thorough factorial design and evaluation of pre- and post-compression parameters, the F3 batch, which contained Rivaroxaban (7.97%), Crospovidone (3.59%), Croscarmellose sodium (5.18%), Sodium Starch Glycolate (5.18%), Lactose Anhydrous (31.08%), Mann

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Abraham, Anuji, Dolapo Olusanmi, Andrew J. Ilott, et al. "Correlation of Phosphorus Cross-Linking to Hydration Rates in Sodium Starch Glycolate Tablet Disintegrants Using MRI." Journal of Pharmaceutical Sciences 105, no. 6 (2016): 1907–13. http://dx.doi.org/10.1016/j.xphs.2016.03.025.

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Yadav, Somdutt, Naresh Kalra, and Pankaj Arora. "Formulation and Optimization of Fast Dissolving Tablets of Zidovudine." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 03 (2024): 1393–400. http://dx.doi.org/10.25258/ijpqa.15.3.47.

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Fast-dissolving tablets (FDTs) have emerged as a prominent alternative to conventional oral dosage forms, particularly for drugs requiring rapid onset of action. This study aims to formulate and optimize fast-dissolving tablets of zidovudine, an antiretroviral medication used in the treatment of HIV/AIDS. The primary objective was to enhance patient compliance by ensuring the tablet disintegrates and dissolves quickly in the oral cavity without the need for water. Using various superdisintegrants like sodium starch glycolate and cross-carmellose sodium into, multiple formulations were prepared

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23

B. H. Al-Khedairy, Eman. "Effect of Additives on the Solubility and Dissolution of Piroxicam From Prepared Hard Gelatin Capsule." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 21, no. 1 (2017): 117–22. http://dx.doi.org/10.31351/vol21iss1pp117-122.

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Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) used in the treatment of musculo-skeletal and joint disorders. The problem with this drug is its poor solubility in water and hence poor bioavailability after oral administration. In order to improve its solubility and dissolution behavior, hydrophilic additives such as starch, lactose, superdisintegrants including crospovidone (C.P), cross carmellose sodium (CCS), and sodium starch glycolate (SSG) were physically dry mixed with the drug by simple trituration. The improvement in the solubility in 0.1 N HCl was obtained as the amount o

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24

Ansari, Mohd Razi, Sumer Singh, M. A. Quazi, Yaasir Ahmed Ansari, and Jameel Abbas. "Formulation, Evaluation and Optimization of Orodispersible Tablets of Naproxen sodium by using Superdisintegrant." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 462–68. http://dx.doi.org/10.22270/jddt.v9i4-s.3361.

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Among the different type of route of administration oral route for drug administration is most common route in which Orodispersible tablet is preferred for the patient which are unconscious, week or for immediate control. The tablet gets dispersed in mouth cavity without water, present study deals with formulation of Naproxen sodium mouth dissolving tablets using super disintegrants. Naproxen sodium is analgesic and NSAID, used for the treatment of pain and inflammation caused by different condition such as osteoarthritis, rheumatoid arthritis and menstrual cramps. However gastric discomfort c

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25

Narasaiah, V. L., Ch Praneetha, P. Mallika, K. Pullamma, S. Shilpa, and P. V. V. Ramakrishna. "DESIGN AND CHARACTERIZATION OF ACECLOFENAC FAST DISSOLVING TABLETS USING SUPER DISINTEGRATING AGENTS." INDIAN DRUGS 51, no. 01 (2014): 34–40. http://dx.doi.org/10.53879/id.51.01.p0034.

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The aim of this project was to develop fast dissolving tablets (FDT) of aceclofenac by wet granulation using super disintegrating agents such as cross carmellose sodium (CCS), Crospovidone (CP) and sodium starch glycolate (SSG) were formulated and evaluated. The tablets evaluated for thickness, hardness, friability weight variation, drug content, water absorption ratio, wetting time, disintegration time and in vitro dissolution studies. The in vitro release studies were conducted in pH 7.4 phosphate buffer. Different release models like zero order, first order, Higuchi and Korsmeyer-Peppas wer

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26

R, Hemraj, and Dilip Agarwal. "Formulation and Evaluation of meclofenamate fast dissolving tablet." Asian Journal of Pharmaceutical Research and Development 10, no. 2 (2022): 138–45. http://dx.doi.org/10.22270/ajprd.v10i2.1044.

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The study of this work was to use a swellable polymer chosen among superdisintegrants, for improving the dissolution rate of a sparingly soluble drug, loaded on its surface. Meclofenamate, which has very low water solubility, was chosen as a model drug, while cross linked sodium carboxymethyl cellulose (Ac-Di-Sol) was chosen as the swellable polymer. The Drug Polymer systems were prepared using direct compression method.The results of the dissolution tests showed that the dissolution rate of Meclofenamate from the systems prepared increase, particularly in the case of the preparation composed

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Dr., Dilip Agrawal, Ashok Kumar Sharma Mr., Rakesh Goyal Dr., Mukesh Bansal Dr., Mohit Khandelwal Mr., and Shaneza Aman Ms. "DEVELOPMENT AND EVALUATION OF FAST DISSOLVING TABLET OF ETORICOXIB BY USING NATURAL SUPERDISINTEGRANT (FENUGREEK POWDER)." International Journal of Current Pharmaceutical Review and Research 12, no. 4 (2020): 01–08. https://doi.org/10.5281/zenodo.12667356.

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The demands for fast dissolving tablets have received ever increasing day by day during thelast two decade. In the proposed present project study, the effect of natural Superdisintegrantswas compared with synthetic Super disintegrants and conventional Super disintegrants in theof fast dissolving tablet formulation of Etoricoxib. Etoricoxib NSAID is used for thetreatment of mild to moderate pain in various conditions like (osteoarthritis) and reducingpain, swelling, and joint stiffness caused with rheumatoid arthritis. In the present work 9formulations of FDT (Fast dissolving tablet) of Etorico

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Rayakwar, Neetesh, and Yuvraj Singh Dangi. "Development and characterization of controlled release bilayered tablets of Citicoline sodium." Journal of Drug Delivery and Therapeutics 9, no. 2-s (2019): 125–31. http://dx.doi.org/10.22270/jddt.v9i2-s.2471.

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Objectives: The aim of present investigation was formulation development and evaluation of bi-layer tablets of citicoline sodium. Materials and Methods: An aqueous granulation process was adopted to formulate citicoline sodium (CTS) bilayer tablets. Wet granulation method has been utilized for the formulation of bilayer CTS tablet. Citicoline sodium, microcrystalline cellulose (pH 101 & 102), HPMC K4, K15, K-100, PVP K-30, Magnesium stearate, cross-carmellose sodium, sodium starch glycolate and red oxide were used for preparation. Pre-formulation studies of citicoline sodium and drug excip

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CHOURSIYA, ARTI, and DEEPIKA PANDIT. "FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF LANSOPRAZOLE BY SOLUBILITY ENHANCEMENT TECHNIQUE." Current Research in Pharmaceutical Sciences 11, no. 2 (2021): 54–64. http://dx.doi.org/10.24092/crps.2021.110203.

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The present study was focused on preparation and evaluation of Lanzoprazole fast dissolving tablets. Lansoprazole (LAN) is a proton pump inhibitor drug and used for the treatment of gastric ulcer. Lansoprazole is acid labile drug and to avoid the acidic pH of the stomach LAN is formulated as oral fast dissolving tablets. Lansoprazole is the class II drug of the BCS classification and has a low aqueous solubility. Hence, to improve the solubility of the drug we have prepared Lansoprazole solid dispersion with poly ethylene glycol and complex with β cyclodextrin. Fast Dissolving tablets of LAN w

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Singh, Harmanpreet, Pooja Jaiswal, Suksham Gupta, and Simerjit Singh. "FORMULATION OF RIZATRIPTAN BENZOATE SUBLINGUAL TABLETS PREPARED BY DIRECT COMPRESSION WITH DIFFERENT BIOADHESIVE POLYMER: IN VITRO AND EX VIVO EVALUATION." Asian Journal of Pharmaceutical and Clinical Research 10, no. 16 (2017): 36. http://dx.doi.org/10.22159/ajpcr.2017.v10s4.21334.

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Objective: The current investigation deals with formulation and evaluation of fast disintegrating sublingual tablets of rizatriptan benzoate (RTB) to produce its intended therapeutic effect for acute treatment of migraine. When the drug is given by sublingual route, it overcomes the first pass metabolism and quick entry of drug in systemic circulation is obtained. It would result in fast pharmacological response hence faster relief from migraine which is an important criterion in migraine therapy.Methods: In this study, RTB sublingual tablets were prepared using direct compression process usin

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Solanki, Nimisha, Arpit Gawshinde, Komal Tikariya, Dharmendra Solanki, and Umesh K. Atneriya. "Formulation and Evaluation of Oral Dispersible Tablet of Poorly Water-Soluble Drug ‘Glimepiride’ by Using Solubility Enhancement Technique." International Journal of Pharmaceutical Sciences and Medicine 9, no. 1 (2024): 62–72. http://dx.doi.org/10.47760/ijpsm.2024.v09i01.005.

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The present study is regarding Glimepiride (GMP) is poorly water-soluble drug. According to the BCS, Glimepiride undergoes Class II - High Permeability and Low Solubility. The objective of the research project is to enhance the solubility of Glimepiride by using solubility enhancement techniques. The endeavor is to improve its solubility by using super disintegrating agent to enhance the ability of disintegration of Oro dispersible tablet. To enhance of solubility of GMP, our select the method i.e. solid dispersion technique because Solid dispersion is an effective way of improving the dissolu

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Avinash, B. Darekar, N. Jadhav Sonali, and B. Saudaga Ravindra. "Design Development and Evaluation of Bilayer Tablet Using Eprosartan Mesylate for the Treatment of Hypertension." International Journal of Current Pharmaceutical Review and Research 8, no. 4 (2017): 328–37. https://doi.org/10.5281/zenodo.12674990.

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The aim of present study is to formulate Eprosartan Mesylate sustained release (SR) and immediate release (IR) bilayertablet by different concentration of Hydroxypropyl methylcellulose (HPMC) and HPMC K 100 M to control the releasepattern. The sustained release layer of Eprosartan Mesylate was prepared by using different grades of HPMC like, HPMCK-100, HPMC along with other excipients by direct compression technique. The immediate release layer of EprosartanMesylate was prepared by Cross carmellose sodium and Sodium starch glycolate by direct compression technique. Thepowders were evaluated fo

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Rony, Farzana Khan, Jonathan Appiah, Asmaa Alawbali, Distinee Clay, Shamsuddin Ilias, and Mohammad A. Azad. "Evaluating Swellable Cross-Linked Biopolymer Impact on Ink Rheology and Mechanical Properties of Drug-Contained 3D-Printed Thin Film." Pharmaceutics 17, no. 2 (2025): 183. https://doi.org/10.3390/pharmaceutics17020183.

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Background/Objectives: Interest in 3D printing oral thin films (OTFs) has increased substantially. The challenge of 3D printing is film printability, which is strongly affected by the rheological properties of the ink and having suitable mechanical properties. This research assesses the suitability of sodium starch glycolate (SSG), a swellable cross-linked biopolymer, on ink rheology and the film’s mechanical properties. Methods: A water-based ink comprising sodium alginate (SA), the drug fenofibrate (FNB), SSG, glycerin, and polyvinylpyrrolidone (PVP) was formulated, and its rheology was asse

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Siddhanshu, Jain, Khandelwal Mohit, Agrawal Dilip, and Goyal Rakesh. "DESIGN, DEVELOPMENT AND EVALUATION OF FAST DISSOLVING TABLET OF TIZANIDINE USING FENUGREEK SEED MUCILAGE." International Journal of Current Pharmaceutical Review and Research 14, no. 03 (2022): 108–12. https://doi.org/10.5281/zenodo.12658808.

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The demands for fast dissolving tablets have received ever increasing day by day during thelast decade. In the present projected study, the effect of natural superdisintegrant wascompared with synthetic super disintegrants and conventional super disintegrants in the offast dissolving tablet formulation of tizanidine Hcl. Tizanidine Hcl is a potent muscle relaxantwhich management of increased muscle tone associated with spasticity. In the present work12 formulations of FDT (Fast dissolving tablet) of tizanidine were prepared by using isolatedmucilage of fenugreek seed was evaluated and compiles

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Shakkarwal, Mahipal, Dr Mukesh Sharma, Dr Ram Garg, Shankar Lal Soni, Gopal Kumar Paswan, and Umansh Naryan. "DEVELOPMENT, FORMULATION AND EVALUATION OF MECLOFENAMATE FAST DISSOLVING TABLETS." Journal of Biomedical and Pharmaceutical Research 10, no. 1 (2021): 59–67. http://dx.doi.org/10.32553/jbpr.v10i1.838.

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The demands for fast dissolving tablets have received ever increasing day by day during the last 10-15 years for the onset of action. In the present study, the effect of superdisintegrant was compared with synthetic super disintegrants and other conventional super disintegrants in the of fast dissolving tablet formulation of Meclofenamate. Meclofenamate is an antihypertensive drug and in case of hypertension immediate treatment is required so the proposed investigation is totally based to provide the suitable treatment for hypertension. In the present work 9 formulations of Fast di

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Siham, Al-Khalidi S. "The effect of some excipients on the formulation of norfloxacin 400mg tablets." Al Mustansiriyah Journal of Pharmaceutical Sciences 1, no. 1 (2004): 14–25. http://dx.doi.org/10.32947/ajps.v1i1.441.

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Norfloxacin a synthetic, broad-spectrum quinolone carboxylic acid derivative, active against Gram negative & Gram-positive bacteria. Used clinically in the treatment of acute and chronic urinary tract infections, cystitis ,urethritis, pyelonephritis, prostatitis& gastroenteritis . This study is concerned with the formulation of 400mg Norfloxacin coated tablets with 710mg weight, 12mm in diameter, less than 10minutes disintegration time, & less than 1 % friability. Many trials were made to prepare a satisfactory tablet formula for the drug by using wet-granulation method with variou

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Arunkumar, Selvi, L. Srinivas, D. Satyavati, and C. Emmanuel. "Comparative Study of Antihypertensive Drugs Amlodipine Besylate /Metoprolol Succinate and Nebivolol Hydrochloride /Valsartan Combinations in Bilayer Tablets." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 529–39. http://dx.doi.org/10.22270/jddt.v9i4-s.3214.

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The present research is an approach to develop a formulation platform that shall help in minimizing the time and effort taken to develop a drug delivery system. Taking bilayer tablet technology as a representation for drug delivery system, well accepted antihypertensive drugs, Amlodipine besylate and Metoprolol succinate were considered as model drugs for the study. Initially the process variables like concentration of the disintegrants, Sodium starch Glycolate and cross carmellose sodium, Polymers HPMC K100M and K4M were standardized with these drugs so that the incorporation of a new combina

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Dr. Usha D S, Jadav Prakruti Kishorchandra, Dr. V. Antony Asir Daniel, et al. "Formulation And Evaluation Of Fast Disintegrating Tablets Of Herbal Powder Extracts For Headache." International Journal of Environmental Sciences 11, no. 9s (2025): 924–34. https://doi.org/10.64252/2ytpqg04.

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Oral medication administration is perhaps the most common method of the dosage form. Researchers have been encouraged by recent technological advancements to produce Fast disintegrating tablets (FDTs) to enhance patient compliance and accessibility. The study was designed to evaluate the composition and efficacy of herbal fast disintegrating tablets for headache care. Herbal powder extracts of Salix alba L (White Willow bark), Tinospora cordifolia (Guduchi), Achyranthes aspera (Latjira), Cyprus rotundus (Nagarmotha), and Withania somnifera (Ashwagandha) are produced and processed into fast dis

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Mohammad Gufran, Mohammad Faizan, Sailesh Kumar Ghatuary, Reena Shende, Prabhat Kumar Jain, and Geeta Parkhe. "Formulation, Development and Evaluation of Bilayer Floating Tablet of Gemfibrozil." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 574–78. http://dx.doi.org/10.22270/jddt.v9i4-s.3401.

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Formulation development is an important part of drug design and development. Bioavailability and bioequivalence are totally dependent on formulation development. Now-a-days formulation development is done by following QbD (Quality by Design).The aim of present study is to formulate Gemfibrozil (Gem) sustained release (SR) and immediate release (IR) bilayer tablet by different concentration of Hydroxypropyl methylcellulose (HPMC) and HPMC K 100 M to control the release pattern. The sustained release layer of Gem was prepared by using different grades of HPMC like, HPMC K-15, HPMC K-4 along with

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Anusha, Pashikanti Sai, and Dr M. Sunitha Reddy. "Formulation and Evaluation of Rosuvastatin Calcium Immediate Release Tablets Using Beta Cyclodextrin." Saudi Journal of Medical and Pharmaceutical Sciences 8, no. 10 (2022): 511–17. http://dx.doi.org/10.36348/sjmps.2022.v08i10.004.

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In order to treat Hyperlipidaemia, Rosuvastatin, a Dyslipidaemia drug, inhibits the HMG-CoA reductase enzyme. However, the calcium form of Rosuvastatin (RST) has low bioavailability, undesirable dissolving characteristics, and issues with absorption. Thus objective of the study is to increase the solubility and dissolution rate of Rosuvastatin calcium a poorly water-soluble 3-hydroxy 3-methyl glutaryl CoA (HMG-CoA) Reductase inhibitor through inclusion Complexation with β-cyclodextrin (β-CD). Therefore, the goal of the current study was to create a Rosuvastatin tablet formulation for oral diss

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M., Anusha, Varun Raj S., Krishna Srewe P.V., Divya Deepthi N., Evanjiline Ch., and Roopa Koteswari Ch. "Formulation and Development of Rosuvastatin Fast Dissloving Tablets using Natural Super Disintegrates." Research & Review: Drugs and Drugs Development 1, no. 2 (2019): 61–77. https://doi.org/10.5281/zenodo.3271091.

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<em>Rosuvastatin is in category of the drug class. It is used to treat high cholesterol and to block cardiovascular disease. The main aim of this study is to develop oral dispersible tablets of Rosuvastatin using different types of super disintegrates to enhance the disintegration and dissolution of Rosuvastatin to improve bioavailability of the drug. Many trials were made to prepare a satisfactory rosuvastatin oral dispersible tablet using direct compression and wet granulation method. Formulate tablets were examine with different parameters such as weight variation, hardness, friability, wet

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Hiral, Chavda D., Sonpal N. Rakshit, Paresh Prajapati A, and Madhabhai M. Patel. "Formulation and Evaluation of Modified Pulsincap as Pulsatile Drug Delivery System for Treatment of Rheumatoid Arthritis." International Journal of Pharmaceutical Sciences and Nanotechnology 9, no. 5 (2016): 3476–87. http://dx.doi.org/10.37285/ijpsn.2016.9.5.5.

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The aim of the present study was to design and evaluate a modified pulsincap pulsatile drug delivery system of etodolac for treatment of rheumatoid arthritis. Capsule body was made water insoluble by cross linking with formaldehyde vapour. It was filled with drug, osmogen NaCl and super disintegrant sodium starch glycolate to expel the drug after predetermined lag time. A hydro gel plug made of HPMC K4M was placed in the capsule body to achieve desired drug release after lag time for chronotherapy of rheumatoid arthritis. Untreated cap was then fitted to the treated body was sealed. Entire uni

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K., L. Deepthi*1 B. Chatrapathi R. Bhaskar B. Jairam L. Gagan Kumar. "FORMULATION AND INVITRO EVALUATION OF MOUTH DISINTEGRATING TABLETS OF MONTELUKAST AND DESLORATADINE." November 30, 2018. https://doi.org/10.5281/zenodo.2530464.

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Montelukast sodium is a leukotriene receptor antagonist, used in the treatment of asthma and Desloratadine is a drug used to treat allergies. The combination formulation is used for the treatment of allergic rhinitis, chronic urticaria. The aim of the present study is to Formulate and evaluate the oral disintegrating tablets of Montelukast sodium and Desloratadine. ODTs were prepared by direct compression method and by using crospovidone, croscarmellose sodium and sodium starch glycollate as superdisintegrants which disintegrates in matter of seconds in the oral cavity, thereby reducing the ti

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Hadia, Huma Niranjan Panda* Vurathi Sreenivasulu L.Rajesh Patro. "FORMULATION DEVELOPMENT AND EVALUATION OF ORODISPERSIBLE TABLETS OF FEXOFENADINE BY USING COMBINATIONS OF SUPERDISINTEGRANTS." May 25, 2023. https://doi.org/10.5281/zenodo.7968928.

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<em>Fexofenadine is prescribed for the treatment of allergy symptoms in males. The liver plays a crucial role in fexofenadine's metabolism. Orodispersible tablets, which are not metabolised in the stomach, were a good choice of dosage form to counteract these limitations. With the goal of achieving rapid disintegration when held beneath the tongue and facilitating direct absorption of the active ingredient by the oral mucosa, the present study sought to design and develop a Fexofenadine Orodispersible Tablet using Croscarmellose Sodium, Cross povidone, and Sodium starch Glycolate as superd

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-, Mahesh Dilip Mane, Nilesh Shashikant Patole -, and Vetal Nana Kodlkar -. "Studies on Formulation and Evaluation of Inlay Tablet for Delivery of an Antidiabetic Drug." International Journal For Multidisciplinary Research 7, no. 1 (2025). https://doi.org/10.36948/ijfmr.2025.v07i01.35827.

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The main objective of the present research work was to develop a inlay tablet containing immediate release core tablet of Glyburide and sustained release cup portion of Metformin Hydrochloride, which is used as an Anti-hyperglycemic agent. Metformin Hydrochloride has biological half-life nearly about 6 hours, so an attempt was made in the direction of preparation and optimization of a combination of sustained release and immediate release in a single tablet. Hydroxy propyl methyl cellulose K100 and Hydroxy propyl methyl cellulose K4M were used as retarding materials and in immediate release so

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R., Rama S. Chithambara Bharathy. "New Oscillation Criteria for Second Order Functional Differential Equations with Several Sublinear Neutral Terms." March 31, 2025. https://doi.org/10.5281/zenodo.15115582.

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With multiple properties to offer a means of a successful drug delivery system, the bilayer tablet represents a new era in the successful development of sustained release drug delivery systems. Bi-layer tablets can be used for both two types of release, where the first layer is an immediate release dose and the second layer is a maintenance dose, as well as for the sequential release of two medications in combination. So, in this current research work an attempt has been made to design floating bilayered tablets using Omeprazole in the immediate layer and Clarithr

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Jyothirmayi, Pasam, Arigela Bharathi, and D. Rama Sekhara Reddy. "Design, Formulation, Evaluation and Statistical Optimization of Coated Floating Pulsatile Tablets for Modified Chronopharmacotherapy of Rheumatoid Arthritis." Research Journal of Pharmacy and Technology, October 18, 2024, 5491–98. https://doi.org/10.52711/0974-360x.2024.00840.

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Objective: Rheumatoid arthritis is a condition that needs early morning medication according to biorhythms. Hence, the main aim of designing Chronomodulated Floating Pulsatile Tablets (CFPT) of opioid analgesic and to perform in vitro drug release, in vitro buoyancy for modified chronopharmacotherapy of rheumatoid arthritis. Methods: The formulation was designed with the immediate core covered with buoyant composition and followed by immediate release layer. The best formulations of core tablets were compression coated with Methocel K100M, Plantago Ovate Gum (POG), and Tamarindus gum (TG) to a

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Senapathi, Chanukya, SwarupaRani Vemuru, Dharani Lakshmi Sadam, Vijay Boddu, and Venu Gopal Chennupalli. "Formulation and Evaluation of Immediate Release Dasatinib Film Coated Tablet." International Journal For Multidisciplinary Research 7, no. 3 (2025). https://doi.org/10.36948/ijfmr.2025.v07i03.49054.

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ABSTRACT: This study focuses on the Formulation and Evaluation of Immediate Release Dasatinib Film Coated Tablet. Oral drug delivery is the most widely utilized route of administration among all the routes that have been explored for systemic delivery of drugs via pharmaceutical products of different dosage forms. Various formulations were prepared by direct compression technique using super disintegrants (cross carmellose sodium, sodium starch glycolate etc.) The main objective is to achieve immediate drug release profile for the developed formulation. Optimized formulation was selected and i

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Pamidi, Sreelatha A. Rajesh Pavan. "Formulation and Evaluation of Floating Bilayer Tablets using Clarithromycin and Omeprazole for management of gastric ulcer." March 31, 2025. https://doi.org/10.5281/zenodo.15115580.

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With multiple properties to offer a means of a successful drug delivery system, the bilayer tablet represents a new era in the successful development of sustained release drug delivery systems. Bi-layer tablets can be used for both two types of release, where the first layer is an immediate release dose and the second layer is a maintenance dose, as well as for the sequential release of two medications in combination. So, in this current research work an attempt has been made to design floating bilayered tablets using Omeprazole in the immediate layer and Clarithr

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Abdul Majid Abdul Mobeen and Prof. Dr. Avinash S. Jeddwar. "Immediate Drug Release Dosage Form : An Update." International Journal of Advanced Research in Science, Communication and Technology, January 9, 2025, 501–9. https://doi.org/10.48175/ijarsct-22952.

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Among all dosage forms tablet is the most popular dosage form existing today because of its convenience of self administration, compactness and easy manufacturing; sometimes immediate onset of action is required than conventional therapy in many cases. So that to overcome these drawbacks, immediate release dosage form has emerged as alternative oral dosage forms. Immediate drug release dosage forms disintegrate rapidly after administration with enhanced rate of dissolution. The basic approach used in development tablets is the use of superdis integrants like Cross linked Polyvinylpyrrolidone o

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