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Journal articles on the topic 'Crossed-aldol condensation'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Chan, T. H., C. J. Li, and Z. Y. Wei. "Crossed aldol type condensation reactions in aqueous media." Journal of the Chemical Society, Chemical Communications, no. 6 (1990): 505. http://dx.doi.org/10.1039/c39900000505.

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2

Mead, Dennis, Rhonda Loh, A. E. Asato, and R. S. H. Liu. "Fluorinated Retinoids via Crossed Aldol Condensation of 1,1,1-Trifluoroacetone." Tetrahedron Letters 26, no. 24 (1985): 2873–76. http://dx.doi.org/10.1016/s0040-4039(00)98859-2.

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3

Suemune, Hiroshi, Osamu Yoshida, Jun Uchida, Yukiko Nomura, Masakazu Tanaka, and Kiyoshi Sakai. "Asymmetric ring cleavage reaction based on crossed aldol condensation." Tetrahedron Letters 36, no. 40 (1995): 7259–62. http://dx.doi.org/10.1016/0040-4039(95)01504-b.

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4

Le, Giau Hoang, Duong Thi Thuy Ngo, Dong Ut Thanh, and Fritz Duus. "Synthesis of 5-arylidene-3-methylrhodanines catalyzed by 1-butyl-3-methylimidazolium chloride in water under microwave irradiation condition." Science and Technology Development Journal 19, no. 2 (2016): 58–63. http://dx.doi.org/10.32508/stdj.v19i2.804.

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Six 5-arylidene-3-methylrhodanine derivatives were synthesized by the crossed aldolization of aromatic aldehydes with 3- methylrhodanine using 1-butyl-3- methylimidazolium chloride ([BMI]Cl) as phase transfer catalyst in water. The reactions, under microwave irradiation (160 watts) during 10 minutes, afforded the yield of 59–83 %. This is the first time [BMI]Cl was used as phase transfer catalyst in the aldol condensation.

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5

Suemune, Hiroshi, Jun Uchida, and Kiyoshi Sakai. "Ring Cleavage Reaction of Heterocyclic Ketones Based on Crossed Aldol Condensation." HETEROCYCLES 43, no. 3 (1996): 625. http://dx.doi.org/10.3987/com-95-7339.

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6

Riadi, Y., R. Mamouni, R. Azzalou, et al. "Animal bone meal as an efficient catalyst for crossed-aldol condensation." Tetrahedron Letters 51, no. 51 (2010): 6715–17. http://dx.doi.org/10.1016/j.tetlet.2010.10.056.

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7

NAKA, Hiroaki, Yasuhiro KANEDA, and Takeo KURATA. "Crossed Aldol Condensation using Anion Exchange Resin as Solid Base Catalyst." Journal of Oleo Science 50, no. 10 (2001): 813–21. http://dx.doi.org/10.5650/jos.50.813.

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8

SUEMUNE, H., O. YOSHIDA, J. UCHIDA, Y. NOMURA, M. TANAKA, and K. SAKAI. "ChemInform Abstract: Asymmetric Ring Cleavage Reaction Based on Crossed Aldol Condensation." ChemInform 27, no. 3 (2010): no. http://dx.doi.org/10.1002/chin.199603084.

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9

Nalini, S., K. G. Sekar, S. Srinivasan, I. Muthuvel, and G. Thirunarayanan. "Insect Antifeedant Active Substituted Styryl 4-Ethoxyphenyl Ketones." Journal of Scientific Research 15, no. 3 (2023): 783–91. http://dx.doi.org/10.3329/jsr.v15i3.63033.

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About eleven substituted styryl 4-ethoxy phenyl ketones were synthesized by ultrasound-promoted greener solvent assisted Crossed Aldol condensation of 4-ethoxy acetophenone and various substituted benzaldehydes. In this method, the obtained yield was more than 85 %. These unsaturated ketones were characterized by their analytical and spectroscopic data. The insect antifeedant activity of these ketones was evaluated by castor leaf discs with the 4th instar larvae Achoea Janata L. All enones showed weak, moderate, and good insect antifeedant activity.

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10

Veisi, Hojat, Zahra Vafajoo, Behrooz Maleki, and Malek Taher Maghsoodlou. "Facile and Convenient Synthesis of 5-Arylalkylidenerhodanines by Electrocatalytic Crossed Aldol Condensation." Phosphorus, Sulfur, and Silicon and the Related Elements 188, no. 6 (2013): 672–77. http://dx.doi.org/10.1080/10426507.2012.717134.

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11

Mahdavinia, Gholam Hossein, Shahnaz Rostamizadeh, Ali Mohammad Amani, and Maryam Mirzazadeh. "NH4H2PO4/SiO2: a recyclable, efficient heterogeneous catalyst for crossed aldol condensation reaction." Green Chemistry Letters and Reviews 5, no. 3 (2012): 255–81. http://dx.doi.org/10.1080/17518253.2011.617317.

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12

Arulkumaran, R., S. Vijayakumar, R. Sundararajan, et al. "Spectral Correlations and Antimicrobial Activities of some 1-Pyrenyl Chalcones." International Letters of Chemistry, Physics and Astronomy 10 (September 2013): 21–38. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.10.21.

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A series of 1-pyrenyl chalcones have been synthesized by Crossed-Aldol condensation of 1-acetylpyrene and substituted benzaldehydes. The purities of these chalcones have been checked by their physical constants, UV, IR, NMR and MASS spectral data. The spectral data of these chalcones have been correlated with Hammett sigma constants, F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effect of substituents on the spectral group frequencies have been discussed. The anti-microbial activities of these chalcones have been evaluated u

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13

Arulkumaran, R., S. Vijayakumar, R. Sundararajan, et al. "Spectral Correlations and Antimicrobial Activities of some 1-Pyrenyl Chalcones." International Letters of Chemistry, Physics and Astronomy 10 (March 18, 2013): 21–38. http://dx.doi.org/10.56431/p-c0x8gf.

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A series of 1-pyrenyl chalcones have been synthesized by Crossed-Aldol condensation of 1-acetylpyrene and substituted benzaldehydes. The purities of these chalcones have been checked by their physical constants, UV, IR, NMR and MASS spectral data. The spectral data of these chalcones have been correlated with Hammett sigma constants, F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effect of substituents on the spectral group frequencies have been discussed. The anti-microbial activities of these chalcones have been evaluated u

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14

Handayani, Sri, Cornelia Budimarwanti, and Winarto Haryadi. "Microwave-Assisted Organic Reactions: Eco-friendly Synthesis of Dibenzylidenecyclohexanone Derivatives via Crossed Aldol Condensation." Indonesian Journal of Chemistry 17, no. 2 (2017): 336. http://dx.doi.org/10.22146/ijc.25460.

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The synthesis of dibenzylidenecyclohexanone derivatives via environmentally friendly Microwave Assisted Organic Synthesis (MAOS) crossed aldol condensation had been carried out. The condensation reaction to synthesize the dibenzylidenecyclohexanone 8b was performed by reacting benzaldehyde 4 and cyclohexanone 2 (mole ratio of 2:1) with NaOH as catalyst for 2 min under microwave irradiation. The benzaldehyde derivatives used in this study were 4-methoxybenzaldehyde and 3,4-dimethoxybenzaldehyde and gave of (2E,6E)-bis(4-methoxy benzylidene)cyclohexanone 8a and (2E,6E)-bis(3,4-dimethoxybenzylide

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15

KURATA, Takeo, and Takeshi FUYA. "Crossed Aldol Condensation Reactions between Various Aldehydes and Acetone Using Solid Base Catalysts." Journal of Japan Oil Chemists' Society 43, no. 8 (1994): 644–49. http://dx.doi.org/10.5650/jos1956.43.644.

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16

Song, Dailei, Yongli Chen, Runxia Wang, Chunsheng Liu, Heng Jiang, and Genxiang Luo. "Crossed-Aldol Condensation of Cycloalkanones with Aromatic Aldehydes Catalyzed by Copper(II) Trifluoroacetate." Preparative Biochemistry and Biotechnology 39, no. 2 (2009): 201–7. http://dx.doi.org/10.1080/10826060902800874.

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17

SUEMUNE, H., J. UCHIDA, and K. SAKAI. "ChemInform Abstract: Ring Cleavage Reaction of Heterocyclic Ketones Based on Crossed Aldol Condensation." ChemInform 27, no. 29 (2010): no. http://dx.doi.org/10.1002/chin.199629056.

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18

Riadi, Y., R. Mamouni, R. Azzalou, et al. "ChemInform Abstract: Animal Bone Meal as an Efficient Catalyst for Crossed-Aldol Condensation." ChemInform 42, no. 13 (2011): no. http://dx.doi.org/10.1002/chin.201113027.

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19

Monasterska, Edyta, Anna Chrobok, Ewa Pankalla, and Agnieszka Siewniak. "Development of Methods for the Synthesis of Neopentyl Glycol by Hydrogenation of Hydroxypivaldehyde." Molecules 26, no. 19 (2021): 5822. http://dx.doi.org/10.3390/molecules26195822.

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Neopentyl glycol (NPG) is a precursor for the manufacture of many valuable products of industrial importance such as polyester, polyurethane and alkyd resins, synthetic lubricants, hydraulic fluids, drugs, etc. The structure of NPG provides the resins with excellent hydrolytic stability, resistance to weather conditions, good flexibility-hardness balance, and outstanding functional properties. The paper presents a literature review on the development of methods for NPG preparation, focusing primarily on the synthesis of NPG by hydrogenation of hydroxypivaldehyde, which is obtained by the cross

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20

John Joseph, S., R. Arulkumaran, D. Kamalakkannan, et al. "Spectral Correlation Analysis and Antimicrobial Activities of some 2,4-Dimethoxy Phenyl Chalcones." International Letters of Chemistry, Physics and Astronomy 23 (November 2013): 48–65. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.23.48.

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A series of 2,4-dimethoxy phenyl chalcones have been synthesized by Crossed-Aldol condensation of 2,4-dimethoxy phenyl and various substituted benzaldehydes. The purities of these chalcones have been checked by their physical constants, UV, IR, NMR and MASS spectral data. The spectral data of these chalcones have been correlated with Hammett sigma constants, F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effects of substituents on the spectral group frequencies have been discussed. The anti-microbial activities of these chalc

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21

John Joseph, S., R. Arulkumaran, D. Kamalakkannan, et al. "Spectral Correlation Analysis and Antimicrobial Activities of some 2,4-Dimethoxy Phenyl Chalcones." International Letters of Chemistry, Physics and Astronomy 23 (November 30, 2013): 48–65. http://dx.doi.org/10.56431/p-26s6na.

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A series of 2,4-dimethoxy phenyl chalcones have been synthesized by Crossed-Aldol condensation of 2,4-dimethoxy phenyl and various substituted benzaldehydes. The purities of these chalcones have been checked by their physical constants, UV, IR, NMR and MASS spectral data. The spectral data of these chalcones have been correlated with Hammett sigma constants, F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effects of substituents on the spectral group frequencies have been discussed. The anti-microbial activities of these chalc

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22

Arulkumaran, R., S. Vijayakumar, R. Sundararajan, et al. "Thionylchloride Catalyzed Aldol Condensation: Synthesis, Spectral Correlation and Antibacterial Activities of some 3,5-Dichloro-2-Hydroxyphenyl Chalcones." International Letters of Chemistry, Physics and Astronomy 4 (September 2013): 17–38. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.4.17.

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A series of substituted styryl 3,5-dichloro-2-hydroxyphenyl ketones [1-(3,5-dichloro-2-hydroxy)-3-phenylprop-2-en-1-one] were synthesized using thionyl chloride assisted Crossed-Aldol reaction. The yields of chalcones were more than 80%. The synthesized chalcones were characterized by analytical and spectroscopic data. From the spectroscopic data the group frequencies were correlated with Hammett substituent constants, F and R parameters. From the results of statistical analysis the effect of substituents were discussed. The antibacterial activities of these chalcones have been evaluated using

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23

Arulkumaran, R., S. Vijayakumar, R. Sundararajan, et al. "Thionylchloride Catalyzed Aldol Condensation: Synthesis, Spectral Correlation and Antibacterial Activities of some 3,5-Dichloro-2-Hydroxyphenyl Chalcones." International Letters of Chemistry, Physics and Astronomy 4 (November 19, 2012): 17–38. http://dx.doi.org/10.56431/p-6ilr3n.

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A series of substituted styryl 3,5-dichloro-2-hydroxyphenyl ketones [1-(3,5-dichloro-2-hydroxy)-3-phenylprop-2-en-1-one] were synthesized using thionyl chloride assisted Crossed-Aldol reaction. The yields of chalcones were more than 80%. The synthesized chalcones were characterized by analytical and spectroscopic data. From the spectroscopic data the group frequencies were correlated with Hammett substituent constants, F and R parameters. From the results of statistical analysis the effect of substituents were discussed. The antibacterial activities of these chalcones have been evaluated using

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24

Salehi, Peyman, Mohammad M. Khodaei, Mohammad A. Zolfigol, and Afsaneh Keyvan. "Solvent-Free Crossed Aldol Condensation of Ketones with Aromatic Aldehydes Mediated by Magnesium Hydrogensulfate." Monatshefte f�r Chemie / Chemical Monthly 133, no. 10 (2002): 1291–95. http://dx.doi.org/10.1007/s007060200107.

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25

Saito, Susumu, Masahito Shiozawa, and Hisashi Yamamoto. "Mixed Crossed Aldol Condensation between Conjugated Esters and Aldehydes Using Aluminum Tris(2,6-diphenylphenoxide)." Angewandte Chemie International Edition 38, no. 12 (1999): 1769–71. http://dx.doi.org/10.1002/(sici)1521-3773(19990614)38:12<1769::aid-anie1769>3.0.co;2-0.

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26

Joseph, S. John, D. Kamalakkannan, R. Arulkumaran та ін. "Assessment of Substituent Effects and Antimicrobial Activities of some 2ʹ,5ʹ-Dimethyl Phenyl Chalcones". International Letters of Chemistry, Physics and Astronomy 24 (грудень 2013): 99–123. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.24.99.

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Some 2ʹ,5ʹ-dimethyl phenyl chalcones have been synthesized by Crossed-Aldol condensation between 2,5-dimethyl acetophenone and various substituted benzaldehydes using catalytic amount of sodium hydroxide and ethanol. The yields of the chalcones are more than 93%. The purities of these chalcones have been checked by their physical constants, UV, IR, NMR and MASS spectral data. The spectral data of these chalcones have been correlated with Hammett sigma constants, F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effects of substi

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27

Joseph, S. John, D. Kamalakkannan, R. Arulkumaran та ін. "Assessment of Substituent Effects and Antimicrobial Activities of some 2ʹ,5ʹ-Dimethyl Phenyl Chalcones". International Letters of Chemistry, Physics and Astronomy 24 (26 грудня 2013): 99–123. http://dx.doi.org/10.56431/p-cdy818.

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Some 2ʹ,5ʹ-dimethyl phenyl chalcones have been synthesized by Crossed-Aldol condensation between 2,5-dimethyl acetophenone and various substituted benzaldehydes using catalytic amount of sodium hydroxide and ethanol. The yields of the chalcones are more than 93%. The purities of these chalcones have been checked by their physical constants, UV, IR, NMR and MASS spectral data. The spectral data of these chalcones have been correlated with Hammett sigma constants, F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effects of substi

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28

HONDA, Tomoki, Jun IKEMOTO, Kazuhiko EDA, and Takeo KURATA. "Crossed Aldol Condensation Reactions in the Presence of Potassium Fluoride Supported on Activated Alumina-neutral." Journal of Japan Oil Chemists' Society 46, no. 1 (1997): 57–62. http://dx.doi.org/10.5650/jos1996.46.57.

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29

Esmaeili, Abbas A., Mehri Salimi Tabas, Mohammad A. Nasseri, and Foad Kazemi. "Solvent-Free Crossed Aldol Condensation of Cyclic Ketones with Aromatic Aldehydes Assisted by Microwave Irradiation." Monatshefte f�r Chemie - Chemical Monthly 136, no. 4 (2005): 571–76. http://dx.doi.org/10.1007/s00706-004-0256-9.

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30

Hudson, Lilith Gentles, and Malcolm P. Stevens. "Synthesis of cross-conjugated polyketones by the crossed-aldol condensation of cyclic ketones with aromatic dialdehydes." Journal of Polymer Science Part A: Polymer Chemistry 33, no. 1 (1995): 71–78. http://dx.doi.org/10.1002/pola.1995.080330108.

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31

Saito, Susumu, Masahito Shiozawa, and Hisashi Yamamoto. "ChemInform Abstract: Mixed Crossed Aldol Condensation Between Conjugated Esters and Aldehydes Using Aluminum Tris(2,6-diphenylphenoxide)." ChemInform 30, no. 36 (2010): no. http://dx.doi.org/10.1002/chin.199936080.

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32

Sekar, Praveen, Shridharshini Kumar, and Senthil Kumar Raju. "An Updated Review on Recent Advancements in the Diverse Biological Applications of Medicinally Privileged Scaffold: Chalcone and its derivatives." International Journal of Medical Sciences and Pharma Research 9, no. 1 (2023): 7–20. http://dx.doi.org/10.22270/ijmspr.v9i1.61.

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Fused heterocyclic compounds rank among the most significant systems in medicinal chemistry because of their wide-ranging biological effects. Among the various class of compounds, chalcones and their derivatives are found to be one of the important classes in the field of synthetic and pharmaceutical chemistry. These derivatives are mainly synthesized by means of Claisen-Schmidt condensation, Crossed Aldol condensation and Knoevenagel condensation reactions, which provides wider applications in the field of medicine. Due to the broader biological applications like antimicrobial, anticancer, an

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33

Sawada, Takenori, Shu Nakayama, Akiko Kawai-Nakamura, Kiwamu Sue, Hiizu Iwamura, and Toshihiko Hiaki. "Synthesis of polyacenequinones via crossed aldol condensation in pressurized hot water in the absence of added catalysts." Green Chemistry 11, no. 10 (2009): 1675. http://dx.doi.org/10.1039/b914784p.

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34

Rajendran, A. "A Facile Tandem Protocol for the Crossed Aldol Condensation in SiO2.OSO3H Ionic Liquid under Solventless Condition." American Chemical Science Journal 1, no. 2 (2011): 50–57. http://dx.doi.org/10.9734/acsj/2011/263.

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35

Khodaei, Mohammad Mehdi, Kiumars Bahrami, and Mohammad Khedri. "ZrCl4as an Efficient Catalyst for Crossed-Aldol Condensation of Cyclic Ketones with Aromatic Aldehydes in Refluxing Ethanol." Journal of the Chinese Chemical Society 54, no. 3 (2007): 807–10. http://dx.doi.org/10.1002/jccs.200700117.

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36

Bhuyan, Bishal, Dibya Jyoti Koiri, Meghali Devi, and Siddhartha Sankar Dhar. "A novel MnFe2O4/graphitic carbon nitride (g-C3N4) nanocomposites as efficient magnetically retrievable catalyst in crossed aldol condensation." Materials Letters 218 (May 2018): 99–102. http://dx.doi.org/10.1016/j.matlet.2018.01.168.

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37

Shaikh, Nadim S., Yeshma M. Kushalappa, Swathi P. Sheshappa, and Hareesh H. Nagaraju. "Iron‐Catalyzed Crossed‐Aldol Condensation for the Synthesis of 3‐Benzylidene‐4‐chromanones: An Efficient Synthesis of Homoisoflavanoids †." ChemistrySelect 4, no. 44 (2019): 13029–33. http://dx.doi.org/10.1002/slct.201903862.

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38

Ibragimov, M. A., M. I. Lazareva, and W. A. Smit. "A Novel Method of Crossed-Aldol Condensation: Alkylation of Trimethylsilyl Enol Ethers by Alkyl 1-Chloro-2-arylthioalkyl Ethers." Synthesis 1985, no. 09 (1985): 880–84. http://dx.doi.org/10.1055/s-1985-31370.

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39

BASAIF, SALEM, and TARIQ SOBAHI. "Stereoselective Crossed-Aldol Condensation of Some Active Methylene Compounds with Aromatic Aldehydes in Aqueous Medium. Synthesisof(2E)-1,3-Disubstituted Propenones." Journal of King Abdulaziz University-Science 17, no. 1 (2005): 107–16. http://dx.doi.org/10.4197/sci.17-1.12.

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40

Yamano, Yumiko, Yumi Fujita, Yukari Mizuguchi та ін. "Synthesis of γ-Hydroxybutenolides Applying Crossed Aldol Condensation in the Presence of a Bulky Lewis Acid and Their Anti-tumor Activity". CHEMICAL & PHARMACEUTICAL BULLETIN 55, № 9 (2007): 1365–70. http://dx.doi.org/10.1248/cpb.55.1365.

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41

Rostami, Amin, and Firoz Ahmad-Jangi. "Sulfamic acid: An efficient, cost-effective and green catalyst for crossed-aldol condensation of ketones with aromatic aldehydes under solvent-free." Chinese Chemical Letters 22, no. 9 (2011): 1029–32. http://dx.doi.org/10.1016/j.cclet.2011.03.015.

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42

Salehi, Peyman, Minoo Dabiri, Mohammad Ali Zolfigol, and Mohammad Ali Bodaghi Fard. "Silica sulfuric acid as an efficient and reusable reagent for crossed-aldol condensation of ketones with aromatic aldehydes under solvent-free conditions." Journal of the Brazilian Chemical Society 15, no. 5 (2004): 773–76. http://dx.doi.org/10.1590/s0103-50532004000500026.

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43

Thapa-Magar, Pradeep, Najma Bajracharya, Ganga Ram Upadhayay, and Gan B. Bajracharya. "Comparative Antioxidant Activity of The Synthesized (E)-Chalcones." Journal of Institute of Science and Technology 29, no. 2 (2024): 29–36. https://doi.org/10.3126/jist.v29i2.64789.

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Depletion of dietary antioxidants has been related to rising of oxidative stress that causes chronic and degenerative diseases such as cancers, Alzheimer and aging. Therefore, finding of a readily available antioxidant is essential to offer potential chemotherapeutics. In this study, (E)-1,3-diphenylprop-2-en-1-one (1), (E)-1-(3-nitrophenyl)-3-phenylprop-2-en-1-one (2), (E)-3-(furan-2-yl)-1-(3-nitropheyl)prop-2-en-1-one (3), (E)-1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one (4), (E)-3-(furan-2-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one (5), (E)-1-(2-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one

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44

Rostami, Amin, and Firoz Ahmad-Jangi. "ChemInform Abstract: Sulfamic Acid: An Efficient, Cost-Effective and Green Catalyst for Crossed-Aldol Condensation of Ketones with Aromatic Aldehydes under Solvent-Free Conditions." ChemInform 43, no. 14 (2012): no. http://dx.doi.org/10.1002/chin.201214084.

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45

Malkar, Radhika S., and Ganapati D. Yadav. "Selectivity Engineering in One Pot Synthesis of Raspberry Ketone: Crossed Aldol Condensation of p -Hydroxybenzaldehyde and Acetone and Hydrogenation over Novel Ni/Zn-La Mixed Oxide." ChemistrySelect 4, no. 7 (2019): 2140–52. http://dx.doi.org/10.1002/slct.201804060.

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46

Rico-Molina, Mario, Juan Ortega-Vidal, Juan Molina-Canteras, Justo Cobo, Joaquín Altarejos, and Sofía Salido. "Synthesis and hLDHA Inhibitory Activity of New Stiripentol-Related Compounds of Potential Use in Primary Hyperoxaluria." International Journal of Molecular Sciences 25, no. 24 (2024): 13266. https://doi.org/10.3390/ijms252413266.

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Human lactate dehydrogenase A (hLDHA) is a homotetrameric isozyme involved in the conversion of glyoxylate into oxalate in the cytosol of liver cells (hepatocytes) and partially responsible for the overproduction of oxalate in patients with the rare disease called primary hyperoxaluria (PH). Recently, hLDHA inhibition has been validated as a safe therapeutic method to try to control the PH disease. Stiripentol (STP) is an approved drug used in the treatment of seizures associated with Dravet’s syndrome (a severe form of epilepsy in infancy) which, in addition, has been drawing interest in rece

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47

Comisar, Craig M., and Phillip E. Savage. "Kinetics of crossed aldol condensations in high-temperature water." Green Chemistry 6, no. 4 (2004): 227. http://dx.doi.org/10.1039/b314622g.

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48

Yuan, De-Qi, Steven D. Dong, and Ronald Breslow. "Cyclodextrin-based class I aldolase enzyme mimics to catalyze crossed aldol condensations." Tetrahedron Letters 39, no. 42 (1998): 7673–76. http://dx.doi.org/10.1016/s0040-4039(98)01717-1.

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49

Tanabe, Yoo, Kumi Mitarai, Takahiro Higashi, Tomonori Misaki, and Yoshinori Nishii. "Efficient one-step synthesis of trialkylsubstituted 2(5H)-furanones utilizing direct Ti-crossed aldol condensation and its application to the straightforward synthesis of (R)-mintlactone and (R)-menthofuranElectronic supplementary information (ESI) available: calculated structures of 7 and 8. See http://www.rsc.org/suppdata/cc/b2/b208077j/." Chemical Communications, no. 21 (October 1, 2002): 2542–43. http://dx.doi.org/10.1039/b208077j.

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YUAN, D. Q., S. D. DONG, and R. BRESLOW. "ChemInform Abstract: Cyclodextrin-Based Class I Aldolase Enzyme Mimics to Catalyze Crossed Aldol Condensations." ChemInform 29, no. 52 (2010): no. http://dx.doi.org/10.1002/chin.199852263.

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