Relevant bibliographies by topics / Crossovers

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Crossovers'

Author: Grafiati
Published: 4 June 2021
Last updated: 6 February 2022

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Journal articles on the topic "Crossovers"

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Hope, Justin C., Lissette Delgado Cruzata, Amit Duvshani, Jun Mitsumoto, Mohamed Maftahi, and Greg A. Freyer. "Mus81-Eme1-Dependent and -Independent Crossovers Form in Mitotic Cells during Double-Strand Break Repair in Schizosaccharomyces pombe." Molecular and Cellular Biology 27, no. 10 (March 12, 2007): 3828–38. http://dx.doi.org/10.1128/mcb.01596-06.

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ABSTRACT During meiosis, double-strand breaks (DSBs) lead to crossovers, thought to arise from the resolution of double Holliday junctions (HJs) by an HJ resolvase. In Schizosaccharomyces pombe, meiotic crossovers are produced primarily through a mechanism requiring the Mus81-Eme1 endonuclease complex. Less is known about the processes that produces crossovers during the repair of DSBs in mitotic cells. We employed an inducible DSB system to determine the role of Rqh1-Top3 and Mus81-Eme1 in mitotic DSB repair and crossover formation in S. pombe. In agreement with the meiotic data, crossovers are suppressed in cells lacking Mus81-Eme1. And relative to the wild type, rqh1Δ cells show a fourfold increase in crossover frequency. This suppression of crossover formation by Rqh1 is dependent on its helicase activity. We found that the synthetic lethality of cells lacking both Rqh1 and Eme1 is suppressed by loss of swi5 +, which allowed us to show that the excess crossovers formed in an rqh1Δ background are independent of Mus81-Eme1. This result suggests that a second process for crossover formation exists in S. pombe and is consistent with our finding that deletion of swi5 + restored meiotic crossovers in eme1Δ cells. Evidence suggesting that Rqh1 also acts downstream of Swi5 in crossover formation was uncovered in these studies. Our results suggest that during Rhp51-dependent repair of DSBs, Rqh1-Top3 suppresses crossovers in the Rhp57-dependent pathway while Mus81-Eme1 and possibly Rqh1 promote crossovers in the Swi5-dependent pathway.
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Meneely, Philip M., Anna F. Farago, and Tate M. Kauffman. "Crossover Distribution and High Interference for Both the X Chromosome and an Autosome During Oogenesis and Spermatogenesis in Caenorhabditis elegans." Genetics 162, no. 3 (November 1, 2002): 1169–77. http://dx.doi.org/10.1093/genetics/162.3.1169.

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Abstract Regulation of both the number and the location of crossovers during meiosis is important for normal chromosome segregation. We used sequence-tagged site polymorphisms to examine the distribution of all crossovers on the X chromosome during oogenesis and on one autosome during both oogenesis and spermatogenesis in Caenorhabditis elegans. The X chromosome has essentially one crossover during oogenesis, with only three possible double crossover exceptions among 220 recombinant X chromosomes. All three had one of the two crossovers in the same chromosomal interval, suggesting that crossovers in that interval do not cause interference. No other interval was associated with double crossovers. Very high interference was also found on an autosome during oogenesis, implying that each chromosome has only one crossover during oogenesis. During spermatogenesis, recombination on this autosome was reduced by ∼30% compared to oogenesis, but the relative distribution of the residual crossovers was only slightly different. In contrast to previous results with other autosomes, no double crossover chromosomes were observed. Despite an increased frequency of nonrecombinant chromosomes, segregation of a nonrecombinant autosome during spermatogenesis appears to occur normally. This indicates that an achiasmate segregation system helps to ensure faithful disjunction of autosomes during spermatogenesis.
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Halldorsson, Bjarni V., Gunnar Palsson, Olafur A. Stefansson, Hakon Jonsson, Marteinn T. Hardarson, Hannes P. Eggertsson, Bjarni Gunnarsson, et al. "Characterizing mutagenic effects of recombination through a sequence-level genetic map." Science 363, no. 6425 (January 24, 2019): eaau1043. http://dx.doi.org/10.1126/science.aau1043.

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Genetic diversity arises from recombination and de novo mutation (DNM). Using a combination of microarray genotype and whole-genome sequence data on parent-child pairs, we identified 4,531,535 crossover recombinations and 200,435 DNMs. The resulting genetic map has a resolution of 682 base pairs. Crossovers exhibit a mutagenic effect, with overrepresentation of DNMs within 1 kilobase of crossovers in males and females. In females, a higher mutation rate is observed up to 40 kilobases from crossovers, particularly for complex crossovers, which increase with maternal age. We identified 35 loci associated with the recombination rate or the location of crossovers, demonstrating extensive genetic control of meiotic recombination, and our results highlight genes linked to the formation of the synaptonemal complex as determinants of crossovers.
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Pender, Brendan, Graham Currie, Alexa Delbosc, and Yibing Wang. "Proactive Recovery from Rail Disruptions through Provision of Track Crossovers and Bus Bridging." Transportation Research Record: Journal of the Transportation Research Board 2275, no. 1 (January 2012): 68–76. http://dx.doi.org/10.3141/2275-08.

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This paper explores the importance of providing track crossovers in addressing the issue of replacement bus services in response to unplanned rail service disruptions by using a case study in Melbourne, Australia. Crossovers determine the point from which rail replacement bus services can operate and thus are critical in determining the scale, costs, and benefits of rail disruption management. Despite research evidence that provision for crossovers is important in managing rail disruption, the research literature gives little guidance concerning how it can be achieved and what the relative costs and benefits of providing crossovers are. Theoretical modeling evaluated passenger and operator impacts of alternative crossover plans for a case study of unplanned service disruptions on a suburban rail line in Melbourne. Results showed that an additional crossover reduced user rail disruption costs by 78% to 96%, while bus hire costs were reduced by 63% to 93%. Results suggested that only a few rail disruptions annually would make the provision of track crossovers financially viable on the basis of savings in rail replacement bus service costs. Research found that locating crossovers as close as possible to areas of major disruption provided the most benefits for users and operators. Sensitivity tests showed that even with significantly lower ridership and a lower frequency of disruption, the addition of crossovers was financially positive and generated substantial user benefits. All highlighted results are with respect to the one suburban rail line under analysis. Provision of additional track crossovers appears to be a highly positive means of reducing costs and improving services. However, research indicates that crossovers can cause disruption on some rail systems, and this factor needs to be considered in rail planning.
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Serra, Heïdi, Christophe Lambing, Catherine H. Griffin, Stephanie D. Topp, Divyashree C. Nageswaran, Charles J. Underwood, Piotr A. Ziolkowski, et al. "Massive crossover elevation via combination of HEI10 and recq4a recq4b during Arabidopsis meiosis." Proceedings of the National Academy of Sciences 115, no. 10 (February 20, 2018): 2437–42. http://dx.doi.org/10.1073/pnas.1713071115.

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During meiosis, homologous chromosomes undergo reciprocal crossovers, which generate genetic diversity and underpin classical crop improvement. Meiotic recombination initiates from DNA double-strand breaks (DSBs), which are processed into single-stranded DNA that can invade a homologous chromosome. The resulting joint molecules can ultimately be resolved as crossovers. In Arabidopsis, competing pathways balance the repair of ∼100–200 meiotic DSBs into ∼10 crossovers per meiosis, with the excess DSBs repaired as noncrossovers. To bias DSB repair toward crossovers, we simultaneously increased dosage of the procrossover E3 ligase gene HEI10 and introduced mutations in the anticrossovers helicase genes RECQ4A and RECQ4B. As HEI10 and recq4a recq4b increase interfering and noninterfering crossover pathways, respectively, they combine additively to yield a massive meiotic recombination increase. Interestingly, we also show that increased HEI10 dosage increases crossover coincidence, which indicates an effect on interference. We also show that patterns of interhomolog polymorphism and heterochromatin drive recombination increases distally towards the subtelomeres in both HEI10 and recq4a recq4b backgrounds, while the centromeres remain crossover suppressed. These results provide a genetic framework for engineering meiotic recombination landscapes in plant genomes.
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van Kampen, Jacqueline. "Crossover restrictions, A-bar pronouns and discourse antecedents." Linguistics in the Netherlands 32 (December 11, 2015): 88–104. http://dx.doi.org/10.1075/avt.32.07kam.

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The difference between weak crossovers and weakest crossovers is usually derived from a distinction between quantifiers and non-quantifiers (Lasnik & Stowell 1991). In this paper I will derive crossover restrictions from a new example set, long movement constructions with Dutch A-bar pronouns. Besides question wh-pronouns and relative pronouns, the set of Dutch A-bar pronouns includes topic d-pronouns not available in English. I will argue that A-bar pronouns constitute a uniform set of quantifiers, be it quantifiers with a discourse antecedent. To explain the present analysis, I take Safir (2004) and Ruys (2004) as a starting point. A major difference between these approaches and my own is that my analysis will make a distinction between strong crossovers as binding failures versus weak and weakest crossovers as a matter of discourse dependency, whereas it is more usual to see a related explanation for strong and weak crossovers versus weakest crossovers.
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Sanchez, Aurore, Céline Adam, Felix Rauh, Yann Duroc, Lepakshi Ranjha, Bérangère Lombard, Xiaojing Mu, et al. "Exo1 recruits Cdc5 polo kinase to MutLγ to ensure efficient meiotic crossover formation." Proceedings of the National Academy of Sciences 117, no. 48 (November 16, 2020): 30577–88. http://dx.doi.org/10.1073/pnas.2013012117.

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Crossovers generated during the repair of programmed meiotic double-strand breaks must be tightly regulated to promote accurate homolog segregation without deleterious outcomes, such as aneuploidy. The Mlh1–Mlh3 (MutLγ) endonuclease complex is critical for crossover resolution, which involves mechanistically unclear interplay between MutLγ and Exo1 and polo kinase Cdc5. Using budding yeast to gain temporal and genetic traction on crossover regulation, we find that MutLγ constitutively interacts with Exo1. Upon commitment to crossover repair, MutLγ–Exo1 associate with recombination intermediates, followed by direct Cdc5 recruitment that triggers MutLγ crossover activity. We propose that Exo1 serves as a central coordinator in this molecular interplay, providing a defined order of interaction that prevents deleterious, premature activation of crossovers. MutLγ associates at a lower frequency near centromeres, indicating that spatial regulation across chromosomal regions reduces risky crossover events. Our data elucidate the temporal and spatial control surrounding a constitutive, potentially harmful, nuclease. We also reveal a critical, noncatalytic role for Exo1, through noncanonical interaction with polo kinase. These mechanisms regulating meiotic crossovers may be conserved across species.
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Zhu, Longfei, Nadia Fernández-Jiménez, Maja Szymanska-Lejman, Alexandre Pelé, Charles J. Underwood, Heïdi Serra, Christophe Lambing, et al. "Natural variation identifies SNI1, the SMC5/6 component, as a modifier of meiotic crossover in Arabidopsis." Proceedings of the National Academy of Sciences 118, no. 33 (August 12, 2021): e2021970118. http://dx.doi.org/10.1073/pnas.2021970118.

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The frequency and distribution of meiotic crossovers are tightly controlled; however, variation in this process can be observed both within and between species. Using crosses of two natural Arabidopsis thaliana accessions, Col and Ler, we mapped a crossover modifier locus to semidominant polymorphisms in SUPPRESSOR OF NPR1-1 INDUCIBLE 1 (SNI1), which encodes a component of the SMC5/6 complex. The sni1 mutant exhibits a modified pattern of recombination across the genome with crossovers elevated in chromosome distal regions but reduced in pericentromeres. Mutations in SNI1 result in reduced crossover interference and can partially restore the fertility of a Class I crossover pathway mutant, which suggests that the protein affects noninterfering crossover repair. Therefore, we tested genetic interactions between SNI1 and both RECQ4 and FANCM DNA helicases, which showed that additional Class II crossovers observed in the sni1 mutant are FANCM independent. Furthermore, genetic analysis of other SMC5/6 mutants confirms the observations of crossover redistribution made for SNI1. The study reveals the importance of the SMC5/6 complex in ensuring the proper progress of meiotic recombination in plants.
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Baioletti, Marco, Gabriele Di Bari, Alfredo Milani, and Valentino Santucci. "An Experimental Comparison of Algebraic Crossover Operators for Permutation Problems." Fundamenta Informaticae 174, no. 3-4 (September 28, 2020): 201–28. http://dx.doi.org/10.3233/fi-2020-1940.

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Crossover operators are very important components in Evolutionary Computation. Here we are interested in crossovers for the permutation representation that find applications in combinatorial optimization problems such as the permutation flowshop scheduling and the traveling salesman problem. We introduce three families of permutation crossovers based on algebraic properties of the permutation space. In particular, we exploit the group and lattice structures of the space. A total of 34 new crossovers is provided. Algebraic and semantic properties of the operators are discussed, while their performances are investigated by experimentally comparing them with known permutation crossovers on standard benchmarks from four popular permutation problems. Three different experimental scenarios are considered and the results clearly validate our proposals.
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Moraglio, Alberto, Yong-Hyuk Kim, Yourim Yoon, and Byung-Ro Moon. "Geometric Crossovers for Multiway Graph Partitioning." Evolutionary Computation 15, no. 4 (December 2007): 445–74. http://dx.doi.org/10.1162/evco.2007.15.4.445.

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Geometric crossover is a representation-independent generalization of the traditional crossover defined using the distance of the solution space. By choosing a distance firmly rooted in the syntax of the solution representation as a basis for geometric crossover, one can design new crossovers for any representation. Using a distance tailored to the problem at hand, the formal definition of geometric crossover allows us to design new problem-specific crossovers that embed problem-knowledge in the search. The standard encoding for multiway graph partitioning is highly redundant: each solution has a number of representations, one for each way of labeling the represented partition. Traditional crossover does not perform well on redundant encodings. We propose a new geometric crossover for graph partitioning based on a labeling-independent distance that filters out the redundancy of the encoding. A correlation analysis of the fitness landscape based on this distance shows that it is well suited to graph partitioning. A second difficulty with designing a crossover for multiway graph partitioning is that of feasibility: in general recombining feasible partitions does not lead to feasible offspring partitions. We design a new geometric crossover for permutations with repetitions that naturally suits partition problems and we test it on the graph partitioning problem. We then combine it with the labeling-independent crossover and obtain a much superior geometric crossover inheriting both advantages.
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Dissertations / Theses on the topic "Crossovers"

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Basu, Roy Sayantani. "Répartition des crossovers méiotiques : hétérogénéité, modélisation de l'interférence, interaction entre voies de formation." Phd thesis, Université Paris Sud - Paris XI, 2014. http://tel.archives-ouvertes.fr/tel-00989127.

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Dans la plupart des organismes, les crossovers se formant au cours de la méiose sont interférérents : deux crossovers sont rarement à proximité. Nous avons étudié ce phénomène en détail dans la plante modèle Arabidopsis thaliana en utilisant une grande population de rétro-croisements, en méiose mâle et en méiose femelle. Nous avons utilisé le modèle Gamma à deux voies, superposant à la voie interférente une proportion p de crossovers d'une deuxième voie non interférente. La méiose femelle montre une interférence plus élevée et une proportion p plus faible que la méiose mâle. Par ailleurs nos comparaisons intra-chromosomiques concluent qu'il existe des variations d'interférence entre le bras gauche et le bras droit d'une part et entre la partie centrale et les régions distales d'autre part. Nous avons ensuite développé des tests statistiques qui ont révélé des hétérogénéités dans la proportion p le long des chromosomes. De telles variations ont ensuite été trouvées dans un jeu de données de tomate où notre analyse statistique nous a permis de montrer pour la première fois sur un organisme "sauvage" que la deuxième voie était très peu interférente et qu'en fait les deux voies avaient un peu de " cross-talk ". Vu que la limitation la plus sévère des modèles utilisés jusqu'à présent est l'hypothèse de constance du paramètre p, nous avons développé un modèle généralisé où les deux voies peuvent avoir des paysages de recombinaison différents. Ce modèle nommé PSL-GS a été implémenté en logiciel et testé sur des données simulées et sur trois jeux de données de plantes. L'utilisation du critère BIC suggère que tout comme chez la tomate, les paysages de recombinaison d'Arabidopsis et du maïs sont différents entre les 2 voies.
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Kanter, Jaimie. "Fan Fiction Crossovers| Artifacts of a Reader." Thesis, Hofstra University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10286513.

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Over twenty-five years ago, Henry Jenkins (1992) wrote that fan fiction writing is evidence of “exceptional reading” (p. 284) in that the fan text reflects a reader’s commentary. This investigation examined the ways in which crossover fan fiction, fan-written fiction that mixes elements of two or more well-known fictional worlds, might reveal evidence of this “exceptional reading.” Using a qualitative content analysis of 5 crossover texts that remix Rowling’s Harry Potter series and Austen’s Pride and Prejudice, the study focused on fan writers-as-readers of the source texts. Drawing on Rosenblatt’s (1988) transactional theory of reading, which posits that meaning resides in the transactions between reader, text, and writer, and that the meaning produced is a “new event,” this research concluded that the fan fiction writers’ crossover texts were, in part, a written record of some of the fan writers’ transactions with the source texts, a partial record of the “new event.” Furthermore, this analysis provided evidence that these fan readers-turned-writers demonstrated a powerful understanding of their intended and anticipated audience, a commanding and controlled use of emulation, and a calculated mingling of worlds—both to sustain and to disrupt the fan canon—in order to present their own interpretations of, comments on, and admiration for the source texts. The crossovers are evidence of “exceptional reading” in that they demonstrate the fan writers’ reading transactions.

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Kimene, Kaya Boniface Dimitri Christel. "Crossovers and phase transitions in Bose-Fermi mixtures." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86471.

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Thesis (MSc)--Stellenbosch University, 2014.
ENGLISH ABSTRACT: We present a theoretical approach that allows for the description of trapped Bose-Fermi mixtures with a tunable interspecies interaction in the vicinity of a Feshbach resonance magnetic field.The many-body physics of the system is treated at equilibrium using the well-established mean-field and local density approximations. This reduces the physics locally to that of a homogeneous system. We observe a rich local phase structure exhibiting both first and second order phase transitions between the normal and BEC phases. We also consider the global properties of the mixture at a fixed number of particles and investigate how the density profiles and the populations of the various particle species depend on the detuning and trap profile.
AFRIKAANSE OPSOMMING: Ons beskou ’n teoretiese beskrywing van gevangde Bose-Fermi mengsels met ’n verstelbare interspesie wisselwerking in die teenwoordigheid van ’n magneties-geïnduseerde Feshbach resonansie. Die veeldeeltjiefisika van die sisteem word by ekwilibrium binne die welbekende gemiddelde-veld en lokale-digtheid benaderings hanteer. Sodoende word die fisika lokaal tot die van ’n homogene sisteem gereduseer. Ons neem ’n ryk fase-struktuur waar met beide eerste- en tweede-orde fase-oorgange tussen die normale en BEK fases. Ons beskou ook die globale eienskappe van die mengsel by ’n vaste totale aantal deeltjies en ondersoek hoe die digtheidsprofiele en deeltjiegetalle van die afstemming en die profiel van die val afhang.
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Barbera, Maria Antonia Petes Thomas D. "Selection and analysis of mitotic crossovers in Saccharomyces cerevisiae." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,959.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.
Title from electronic title page (viewed Dec. 18, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Curriculum in Genetics and Molecular Biology." Discipline: Genetics and Molecular Biology; Department/School: Medicine.
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Alves, Sidiney Geraldo. "Leis de escala e Crossovers em modelos de crescimento." Universidade Federal de Minas Gerais, 2006. http://hdl.handle.net/1843/IACO-6WLS8K.

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Nesta tese de doutoramento, estudamos leis de escalas e Crossovers em modelos de crescimento de agregados e interfaces. Nossa abordagem consiste em uma analise de modelos discretos por meio de simulações com o objetivo de investigar suas classes de universalidade e o aparecimento de crossovers. Na primeira parte da tese, analisamos as propriedades de escala em interfaces. O primeiro modelo de crescimento de interfaces estudado foi construído para capturar os efeitos da competição entre a deposição e difusão de partículas. Encontramos uma transição no comportamento da rugosidade, que exibe um expoente de crescimento referente à classe de universalidade de Mullins-Hering (MH) para tempos curtos e à classe de Villain-Lai-Das Sarma (VLDS) para tempos longos. Em seguida, investigamos o modelo de Wolf-Villain com uma modificação na regra de crescimento introduzida para estudar crossovers. Concluímos esta parte da tese analisando estruturas com simetria radial, com atenção particular a detalhes associados à estratégia de medida da rugosidade que podem levar a conclusões equivocadas dos expoentes e, conseqüentemente, da classe de universalidade dos sistemas consederados. Na parte seguinte, consideramos transições morfológicas em modelos de agregação de partículas. Estudamos generalizações do modelo de agregação limitada por difusão (DLA). Na primeira, consideramos o efeito de uma tendência nas trajetórias das partículas. Mostramos que os agregados apresentam uma transição morfológica entre o modelo DLA e o modelo de agregação balística (BA) e caracterizamos quantitativamente essa transição por meio do comprimento característico. Em seguida, estudamos a anisotropia em agregados obtidos no modelo DLA através de uma generalização que inclui uma probabilidade de crescimento às regras de evolução e da aplicação da técnica de redução de ruído. Esse modelo apresenta um rico comportamento quando variamos os parâmetros envolvidos. Finalizamos essa tese com um modelo de agregação o qual consiste de uma mistura de partículas que executam caminhadas aleatórias e trajetórias balísticas. Neste modelo, encontramos uma transição suave de agregados semelhantes àqueles do modelo DLA para os do BA. No outro resultado está no campo dos modelos computacionais híbridos. Em particular, o Computador Semi-quântico. Nós investigamos o desempenho dos algoritmos de Busca e de Transformada de Fourier sobre esta arquitetura híbrida, constituída de processadores clássicos e quânticos trabalhando em conjunto. Mostramos que este tipo de modelo, o Semi-quântico, pode ser melhor que uma arquitetura puramente clássica, mesmo que trabalhando com poucos qubits, o que, por outro lado, pode ser mais fácil para uma implementação com a tecnologia corrente.
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Boddapati, Pavani. "Comparative study of type 2 crossovers and median u-turns." Diss., Columbia, Mo. : University of Missouri-Columbia, 2008. http://hdl.handle.net/10355/5676.

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Thesis (M.S.)--University of Missouri-Columbia, 2008.
The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on August 10, 2009) Includes bibliographical references.
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Frezza, Giulia. "The concept of interaction : crossovers among biology, logic and philosophy." Paris 7, 2011. http://www.theses.fr/2011PA070008.

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Mon travail propose l'histoire épistémologique du concept d'interaction, que j'ai appelée son "hidden epistemological exaptation", à partir des domaines de la physique (complementarity principle) et de la psychologie (Gestalttheorie) en arrivant à la biologie contemporaine. Ma thèse est que, de ce point de vue, l'interaction est un processus doté d'une polarité. Il a un coté positif, du point de vue de l'action coordonnée entre deux dynamiques ou processus, mais, d'autre part, il a un coté négatif, en tant qu’inter-férence (littéralement: inter-fero en Latin, amener) qui résulte de la co-constitution dans le développement du processus même. Deuxièmement, je propose une comparaison entre ces analyses sur l'interaction et celles qui ont été achevées par l'approche géométrique de Jean-Yves Girard en logique linéaire et en Géométrie de l'Interaction (GdI) qui portent notamment à considérer le lien étroit entre l'interaction et la dualité en logique. L'analyse de l'usage et de la diffusion du ternie "interaction" dans les différents domaines montre une croissance intensive et extensive, notamment dans les 40 dernières années. J'en conclus que le concept d'interaction constitue une "rupture épistémologique" qui met en lumière un cadre épistémologique très expressif pour décrire les être vivants d'un point de vue théorique
My work discusses a possible epistemological history of the concept of interaction, which outlines what I name its hidden epistemological exaptation, from the domain of physics (complementarity principle) and psychology (Gestalttheorie) to its recent developments in biology. I advocate that, from this point of view, the interaction results a process due of a polarity. It has a "positive pole", being the coordinated action between two dynamics, or processes. At the same time it has a "negative pole" being an inter-ference (literally: inter-fero from Latin, to bear), in the sense of a result of the co-constitution in the development of the actual process. Moreover I stress a parallel between the discussed investigations about interaction and those achieved by Girard's geometric approach in linear logic and "Geometry of Interaction" (Gol). I especially point out the link between the notion of interaction and that of duality in logic. The analysis of the use and diffusion of the term "interaction" in various scientifïc disciplines shows an intense and extensive growth especially within the last forty years. I propose that we are assisting to a proper epistemological breaking which indicates that the concept of interaction has become now a precious epistemological framework for describing living phenomena from a theoretical point of view
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Fernandes, Joiselle Blanche. "Identification et caractérisation fonctionnelle de gènes contrôlant la fréquence de crossovers méiotiques." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS303/document.

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Les crossing-overs (CO) sont issus d’échange réciproque de matériel génétique entre les chromosomes homologues. Les COs produisent de la diversité génétique et sont essentiels chez la plupart des eucaryotes, pour la distribution équilibrée des chromosomes lors de la méiose. Malgré leur importance, et un large excès de précurseurs moléculaires, le nombre de CO est très limité dans la grande majorité des espèces (Typiquement 1 à 4 par paire de chromosomes). Cela suggère que les COs sont étroitement régulés, mais les mécanismes sous-jacents sont mal connus. Pour identifier les gènes qui limitent la formation des CO, l’équipe a mené un crible génétique chez Arabidopsis thaliana. Ces travaux ont mené à l’identification de plusieurs facteurs anti-CO, définissant trois voies : (i) L’hélicase FANCM et ses co-facteurs ; (ii) L’AAA-ATPase FIDGETIN-LIKE-1 (FIGL1) ; (iii) Le complexe RECQ4-Topoisomerase 3α-RMI1.Le premier objectif de ma thèse est d’explorer les relations entre ces trois voies en s’attachant aux questions suivantes ; (1) Jusqu’où peut-on augmenter la recombinaison en combinant les mutations dans FANCM, FIGL1 et RECQ4 ? Nous avons montré que la plus forte augmentation de recombinaison était obtenue dans recq4 figl1, atteignant 7,5 fois la fréquence du sauvage en moyenne sur le génome. (2) Quel est la distribution de ces extra-COs ? L’augmentation de recombinaison n’est pas homogène le long du génome : Les fréquences de CO augmente fortement des centromères vers les télomères, avec les plus hautes fréquences observées dans les régions distales. (3) La modification des fréquences de recombinaison est-elle identique lors des méioses mâles et femelle ? Chez le sauvage, la fréquence de recombinaison est plus élevée lors de la méiose mâle que femelle. Au contraire, la recombinaison femelle devient plus élevée que la recombinaison mâle chez les mutants recq4 et recq4 figl1. Ceci suggère que des contraintes qui s’appliquent sur la formation des CO lors de la méiose femelle sont relâchées chez ces mutants. En poursuivant le crible génétique, un nouveau mutant hyper-recombinant a été identifié. Le second objectif de ma thèse fut d’identifier et de caractériser fonctionnellement le gène correspondant. Une cartographie génétique et des études d’interactions protéine-protéine, ont mené à l’identification d’un facteur qui interagit directement avec FIGL1 et semble former un complexe conservé depuis les plantes jusqu’au mammifères. Nous avons baptisé cette protéine FLIP (Fidgetin-like-1 interacting protein). Les fréquences de recombinaisons sont augmentées dans flip-1, confirmant que FLIP1 limite la formation des COs. Des études d’épistasie ont montré que FLIP et FIGL1 agissent dans la même voie. De plus les protéines FIGL1/FLIP d’Arabidopsis ou humaine, interagissent avec RAD51 et DMC1, les deux protéines qui catalyse une étape clef de la recombinaison, l’invasion d’un ADN homologue. Finalement, dans flip comme dans figl1, la dynamique de DMC1 est modifiée. Nous proposons donc un modèle dans lequel le complexe FLIP-FIGL1 régule négativement l’activité de RAD51/DMC1 pour limiter la formation des COs. L’étude du complexe conservé FLIP-FIGL1 a mis en évidence un nouveau mode de régulation de la recombinaison, qui agit vraisemblablement à l’étape clé de l’échange de brin homologue. De plus, l’augmentation des CO sans précédent obtenues chez recq4 figl1 peut être d’un grand intérêt pour l’amélioration des plantes en permettant de diversité de nouvelles combinaisons alléliques
Meiotic crossovers (CO) are formed by reciprocal exchange of genetic material between the homologous chromosomes. CO generate genetic diversity and are essential for the proper segregation of chromosomes during meiosis in most eukaryotes. Despite their significance and a large excess of CO precursors, CO number is very low in vast majority of species (typically one to three per chromosome pair). This indicates that COs are tightly regulated but the underlying mechanisms of this limit remain elusive. In order to identify genes that limit COs, a genetic screen was performed in Arabidopsis thaliana. This led to the identification and characterization of several anti-CO factors belonging to three different pathways: (i) The FANCM helicase and its cofactors (ii) The AAA-ATPase FIDGETIN-LIKE-1 (FIGL1) (iii) The RECQ4 -Topoisomerase 3α-RMI1 complex. The first objective was to understand the functional relationship between these three pathways and to address following questions: (1) how far can we increase recombination when combining mutations in FANCM, FIGL1 and RECQ4? We show that the highest increase in recombination was obtained in figl1 recq4, reaching to 7.5 fold the wild type level, on average genome wide. (2) How is the distribution of recombination events genome wide in mutants? The increased CO frequency in the mutants was not uniform throughout the genome. CO frequency rises from the centromere to telomeres, with distal intervals having highest COs (3) is the recombination frequency increase same in both male and female? In Arabidopsis wild type, male has higher recombination than female meiosis. In contrast, in recq4 and recq4 figl1, female recombination was higher than male. This suggests that certain constraints that apply to CO formation in wild type females are relieved in the mutant. By continuing the same genetic screen, a novel anti-CO mutant was identified. The second objective was to identify and functionally characterize the corresponding gene. Genetic mapping and protein interaction studies led to the identification of a factor that directly interacts with FIGL1 and appears to form a conserved complex both in Arabidopsis and humans. Hence, the factor was named FLIP (Fidgetin-like-1 interacting protein). Recombination frequency is increased in flip, confirming that FLIP limit COs. Epistasis studies showed that FLIP and FIGL1 act in same pathway. Further, FIGL1/FLIP proteins of Arabidopsis and humans directly interact with the recombinases RAD51 and DMC1 which catalyze a crucial step of homologous recombination, the inter homolog strand invasion. In addition flip like figl1 modifies dynamics of DMC1. We thus propose a model wherein the FLIP-FIGL1 complex negatively regulates RAD51/DMC1 to limit CO formation. Studying the conserved FIGL1-FLIP complex led to the identification of a novel mode of regulation of recombination, that likely acts at the key step of homologous strand invasion. Further the unprecedented level of CO increase in recq4figl1 in hybrids could be of great interest for crop improvement, allowing the production of novel allele combinations
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Akula, Mohan Kumar. "Guidelines for safety and design improvements at rural expressway median crossovers /." free to MU campus, to others for purchase, 2003. http://wwwlib.umi.com/cr/mo/fullcit?p1417999.

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Sandhu, Amritpal Singh. "Manipulating the frequency and distribution of genetic crossovers during meiosis in barley." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/6316/.

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In commercial barley cultivars meiotic crossover (CO) distribution is skewed to the distal regions of the paired chromosomes. This restricts recombination to these regions thereby reducing the potential genetic variation that can be exploited in plant breeding programs. The aim of this project was to develop experimental strategies that will enable the frequency and distribution of meiotic crossovers to be modified in order to generate progeny with novel gene combinations. Treatment with the histone deacetylase inhibitor trichostatin A, led to significant modifications in crossover frequency in a concentration-dependent manner with lower concentrations not greatly impacting fertility, allowing for the extraction of fertile seeds. The genetic screening of a treated marker population at The James Hutton Institute (JHI), demonstrated subtle but significant shifts in the distribution of meiotic recombination, indicating that modifying recombination through chemicals applied via the transpiration stream is indeed feasible in barley and hence, possibly in other cereals. The cytological study of a barley desynpatic mutant \(des8\) in collaboration with JHI revealed that synapsis is normal despite reduced chiasma frequency. Genetic mapping studies are in progress to identify the mutant gene responsible for this phenotype which will help us to improve our current knowledge of meiosis in barley.
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Books on the topic "Crossovers"

1

Crossovers: Poems. Cheney, WA: Eastern Washington University Press, 1995.

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The design of active crossovers. Waltham, MA: Focal Press/Elsevier, 2011.

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Self, Douglas. The Design of Active Crossovers. Second edition. | New York, NY : Routledge, 2018.: Routledge, 2018. http://dx.doi.org/10.4324/9781315187891.

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Sharan, Shlomo. Crossovers: Anti-zionism & anti-semitism. New Brunswick, N.J: Transaction Publishers, 2010.

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Foundation, Asia-Europe. Enabling crossovers: Good practices in the creative industries. Singapore: Asia-Europe Foundation, 2014.

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Crossovers: Language and orality in anglophone Caribbean poetry. Perugia: Morlacchi, 2011.

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From Black to Schwarz: Cultural crossovers between African America and Germany. East Lansing: Michigan State University Press, 2011.

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LeRoy, Michael H. Strike crossovers and striker replacements: An empirical test of the NLRB's no-presumption policy. Champaign, IL: Institute of Labor and Industrial Relations, University of Illinois at Urbana-Champaign, 1991.

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Carnochan, Stuart. Orbit and altimetric corrections for the ERS satellites through analysis of single and dual satellite crossovers. Birmingham: Aston University. Department of Civil Engineering, 1996.

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Friedman, Michael Jan. Crossover. New York: Pocket Books, 1995.

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Book chapters on the topic "Crossovers"

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Squires, Claire. "Crossovers." In Marketing Literature, 147–75. London: Palgrave Macmillan UK, 2007. http://dx.doi.org/10.1057/9780230593008_7.

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Thomas, Richard C. "Crossovers." In Long Term Human-Computer Interaction, 117–38. London: Springer London, 1998. http://dx.doi.org/10.1007/978-1-4471-1548-9_7.

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Newell, Philip, and Keith Holland. "Crossovers." In Loudspeakers, 137–64. Second edition. | New York, NY : Routledge, 2019. | Series: Audio Engineering Society presents ...: Routledge, 2018. http://dx.doi.org/10.4324/9781315149202-5.

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Colloms, Martin, and Paul Darlington. "Systems and Crossovers." In High Performance Loudspeakers, 263–359. West Sussex, England: John Wiley & Sons, Ltd,., 2013. http://dx.doi.org/10.1002/9780470094327.ch6.

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Reid, Ben. "Crossovers double-crossed." In Routledge handbook of the contemporary Philippines, 386–95. New York : Routledge, 2018.: Routledge, 2018. http://dx.doi.org/10.4324/9781315709215-31.

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Penner, Alvin. "Topology of Merges/Crossovers." In Fitting Splines to a Parametric Function, 27–36. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-12551-6_5.

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Heiselberg, Henning. "Crossovers in Unitary Fermi Systems." In The BCS-BEC Crossover and the Unitary Fermi Gas, 49–97. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-21978-8_3.

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Krawiec, Krzysztof. "Medial Crossovers for Genetic Programming." In Lecture Notes in Computer Science, 61–72. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-29139-5_6.

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Sharan, Shlomo, and David Bukay. "Jews in Islam—The Anti-Semitic Perception." In Crossovers, 1–28. Routledge, 2018. http://dx.doi.org/10.4324/9780203794326-1.

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Sharan, Shlomo, and David Bukay. "The Arab “Refugees:” A Historical View, Not a Narrative." In Crossovers, 29–48. Routledge, 2018. http://dx.doi.org/10.4324/9780203794326-2.

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Conference papers on the topic "Crossovers"

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Lin, Feng, and Qian Cui. "Design of Reconfigurable Crossovers." In 2018 IEEE International Conference on Computational Electromagnetics (ICCEM). IEEE, 2018. http://dx.doi.org/10.1109/compem.2018.8496595.

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Baake, Michael. "Repeat distributions from unequal crossovers." In Stochastic Models in Biological Sciences. Warsaw: Institute of Mathematics Polish Academy of Sciences, 2008. http://dx.doi.org/10.4064/bc80-0-3.

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Bicudo, Pedro, Marco Cardoso, and N. Cardoso. "QCD confinement and chiral crossovers." In The many faces of QCD. Trieste, Italy: Sissa Medialab, 2011. http://dx.doi.org/10.22323/1.117.0015.

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Yoon, Yourim, Yong-Hyuk Kim, Alberto Moraglio, and Byung-Ro Moon. "Geometric crossovers for real-code representation." In the 9th annual conference. New York, New York, USA: ACM Press, 2007. http://dx.doi.org/10.1145/1276958.1277268.

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Pica Ciamarra, Massimo, and Peter Sollich. "Density anomalies and high-order jamming crossovers." In 4TH INTERNATIONAL SYMPOSIUM ON SLOW DYNAMICS IN COMPLEX SYSTEMS: Keep Going Tohoku. American Institute of Physics, 2013. http://dx.doi.org/10.1063/1.4794565.

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Heyen, Johann, Denis Notel, and Arne F. Jacob. "Compact Multiple Crossovers in Millimeter-Wave Circuits." In 33rd European Microwave Conference, 2003. IEEE, 2003. http://dx.doi.org/10.1109/euma.2003.341122.

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Heyen, J., D. Notel, and A. F. Jacob. "Compact multiple crossovers in millimeter-wave circuits." In 33rd European Microwave Conference Proceedings. IEEE, 2003. http://dx.doi.org/10.1109/eumc.2003.177640.

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PRISCHEPA, S. L., C. ATTANASIO, C. COCCORESE, L. MARITATO, M. SALVATO, and A. N. LYKOV. "DIMENSIONAL CROSSOVERS IN SUPERCONDUCTOR - SPIN GLASS NANOSTRUCTURES." In Reviews and Short Notes to Nanomeeting '97. WORLD SCIENTIFIC, 1997. http://dx.doi.org/10.1142/9789814503938_0018.

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Kaleem, S., S. Humbla, S. Rentsch, J. Trabert, D. Stopel, J. Muller, and M. A. Hein. "Microwave crossovers using cascaded couplers for switching applications." In 2012 IEEE International Conference on Wireless Information Technology and Systems (ICWITS). IEEE, 2012. http://dx.doi.org/10.1109/icwits.2012.6417695.

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Dukic, I. M., and L. D. Milic. "Magnitude Complementary Digital Filter Pairs as Loudspeaker Crossovers." In EUROCON 2005 - The International Conference on "Computer as a Tool". IEEE, 2005. http://dx.doi.org/10.1109/eurcon.2005.1630278.

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Reports on the topic "Crossovers"

1

Spears, William M., and Kenneth A. De Jong. An Analysis of Multi-Point Crossover,. Fort Belvoir, VA: Defense Technical Information Center, January 1990. http://dx.doi.org/10.21236/ada294057.

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Spears, William M., and Kenneth D. De Jong. On the Virtues of Parameterized Uniform Crossover,. Fort Belvoir, VA: Defense Technical Information Center, January 1995. http://dx.doi.org/10.21236/ada293985.

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Paesani, Francesco. Theoretical Studies of Spin Crossover Metal-Organic Frameworks. Office of Scientific and Technical Information (OSTI), June 2013. http://dx.doi.org/10.2172/1436510.

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Spears, William M., and Vic Anand. A Study of Crossover Operators in Genetic Programming. Fort Belvoir, VA: Defense Technical Information Center, January 1991. http://dx.doi.org/10.21236/ada294071.

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Daniels, Rachel. Spousal Crossover Effects of Job Demands on Health. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.95.

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Caughlin, David. Dynamic Job Satisfaction Shifts: Implications for Manager Behavior and Crossover to Employees. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.2342.

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Haas, Stephan. Quantum Quench Dynamics–Crossover Phenomena in Nonequilibrium Correlated Quantum Systems (Final Technical Report). Office of Scientific and Technical Information (OSTI), July 2020. http://dx.doi.org/10.2172/1635523.

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Green, Andre. LUNA Condition-Based Monitoring Update: Random Forest and Mahalanobis Ensemble Accuracy Crossover Point. Office of Scientific and Technical Information (OSTI), September 2021. http://dx.doi.org/10.2172/1820056.

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Lo, Shih-tse, and Dhanoos Sutthiphisal. Crossover Inventions And Knowledge Diffusion Of General Purpose Technologies? Evidence From The Electrical Technology. Cambridge, MA: National Bureau of Economic Research, May 2008. http://dx.doi.org/10.3386/w14043.

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Özükoç, Can. Reducing Anxiety in Children with Molar Incisor Hypomineralization Using Virtual Reality - a Randomized Crossover Study. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, November 2020. http://dx.doi.org/10.7546/crabs.2020.11.16.

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