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1

BUCARETCHI, Fábio, Sílvia Regina Fontoura HERRERA, Stephen HYSLOP, Emílio Carlos Elias BARACAT, and Ronan José VIEIRA. "Snakebites by Crotalus durissus ssp in children in Campinas, São Paulo, Brazil." Revista do Instituto de Medicina Tropical de São Paulo 44, no. 3 (2002): 133–38. http://dx.doi.org/10.1590/s0036-46652002000300004.

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From January, 1984 to March, 1999, 31 children under 15 y old (ages 1-14 y, median 8 y) were admitted after being bitten by rattlesnakes (Crotalus durissus ssp). One patient was classified as "dry-bite", 3 as mild envenoming, 9 as moderate envenoming and 18 as severe envenoming. Most patients had neuromuscular manifestations, such as palpebral ptosis (27/31), myalgia (23/31) and weakness (20/31). Laboratory tests suggesting rhabdomyolysis included an increase in total blood creatine kinase (CK, 28/29) and lactate dehydrogenase (LDH, 25/25) levels and myoglobinuria (14/15). The main local signs
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2

Passero, L. F. D., T. Y. Tomokane, C. E. P. Corbett, M. D. Laurenti, and M. H. Toyama. "Comparative studies of the anti-leishmanial activity of three Crotalus durissus ssp. venoms." Parasitology Research 101, no. 5 (2007): 1365–71. http://dx.doi.org/10.1007/s00436-007-0653-1.

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3

Viera, Benedito Barra, Kunie Yabuki Rabello Coelho, Paulo Roberto Curi, and Domingos Alves Meira. "Liver dysfunction in patients bitten by Crotalus durissus terrificus (Laurenti, 1768) snakes in Botucatu (State of São Paulo, Brazil)." Revista do Instituto de Medicina Tropical de São Paulo 37, no. 1 (1995): 59–69. http://dx.doi.org/10.1590/s0036-46651995000100010.

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Thirty-two patients bitten by venomous snakes sixteen by Bothrops spp. and sixteen by Crotalus durissus terrificus were studied. The group comprised thirty males and two females, aged eight to sixty-three years (mean 33±15). Bromsulphalein tests were increased in the majority of patients bitten by Crotalus durissus terrificus. The correlation coefficient of Spearman was positive between bromsulphalein tests and alanine aminotransferase levels, and between alanine aminotransferase and aspartate aminotransferase levels only in the Crotalus group. The only patient who died was bitten by Crotalus
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4

Meléndez-Martínez, David, Luis Fernando Plenge-Tellechea, Ana Gatica-Colima, Martha Sandra Cruz-Pérez, José Manuel Aguilar-Yáñez, and Cuauhtémoc Licona-Cassani. "Functional Mining of the Crotalus Spp. Venom Protease Repertoire Reveals Potential for Chronic Wound Therapeutics." Molecules 25, no. 15 (2020): 3401. http://dx.doi.org/10.3390/molecules25153401.

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Chronic wounds are a major health problem that cause millions of dollars in expenses every year. Among all the treatments used, active wound treatments such as enzymatic treatments represent a cheaper and specific option with a fast growth category in the market. In particular, bacterial and plant proteases have been employed due to their homology to human proteases, which drive the normal wound healing process. However, the use of these proteases has demonstrated results with low reproducibility. Therefore, alternative sources of proteases such as snake venom have been proposed. Here, we perf
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5

O'Dwyer, L. H., T. C. Moço, T. H. Barrella, F. C. Vilela, and R. J. Silva. "Prevalence of Hepatozoon spp. (Apicomplexa, Hepatozoidae) among recently captured Brazilian snakes." Arquivo Brasileiro de Medicina Veterinária e Zootecnia 55, no. 3 (2003): 309–14. http://dx.doi.org/10.1590/s0102-09352003000300010.

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The goal of this study was to determine the prevalence of Hepatozoon spp. infection in recently captured snakes from Botucatu, São Paulo State, Brazil. Blood was collected from all snakes by ventral tail venipuncture. Blood smears were air dried, fixed with methanol, and stained with 10% Giemsa solution. The slides were microscopically examined for detection of hemoparasites by light microscopy at 250x magnification. A total of 238 snakes from 23 species were examined, of which 135 (56.7%) were venomous and 103 (43.3%) non-venomous snakes. The more numerous venomous species sampled were Crotal
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6

Tokarnia, Carlos Hubinger, and Paulo Vargas Peixoto. "A importância dos acidentes ofídicos como causa de mortes em bovinos no Brasil." Pesquisa Veterinária Brasileira 26, no. 2 (2006): 55–68. http://dx.doi.org/10.1590/s0100-736x2006000200001.

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A revisão da literatura pertinente indica que as opiniões sobre a importância dos acidentes ofídicos, como causa de mortes em bovinos no Brasil, são divergentes no meio veterinário. Enquanto alguns acreditam que são pouco importantes, ou que têm menor significado do que lhes é atribuído, outros são da opinião que esses acidentes são freqüentes. Verificou-se que só foi relatado diagnóstico fundamentado de dois casos fatais de envenenamento por Bothrops spp em bovinos, e de nenhum por Crotalus spp. Um questionário por nós submetido a patologistas e clínicos veterinários que atuam em diversos Est
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7

Lara-Galván, Jesús Lenin, Juan Felipe Martínez-Montoya, José Jesús Sigala-Rodríguez, et al. "Rattlesnake (Crotalus spp.) distribution and diversity in Zacatecas, Mexico." ZooKeys 1005 (December 18, 2020): 103–32. http://dx.doi.org/10.3897/zookeys.1005.56964.

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Mexico is home to a large number of reptile species and has one of the greatest diversities of venomous snakes, among which the rattlesnakes pertaining to the Crotalus genus stand out. Out of more than 40 species in the country, nine are found in Zacatecas: C. aquilus, C. atrox, C. basiliscus, C. lepidus, C. molossus, C. polystictus, C. pricei, C. scutulatus and C. willardi. Although these reptiles are important, due to their relevance in terms of ecology, cultural use and public health, their conservation is impacted by multiple factors, such as habitat fragmentation and indiscriminate killin
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8

Grupka, Lisa M., Edward C. Ramsay, and David A. Bemis. "SALMONELLA SURVEILLANCE IN A COLLECTION OF RATTLESNAKES (CROTALUS SPP)." Journal of Zoo and Wildlife Medicine 37, no. 3 (2006): 306–12. http://dx.doi.org/10.1638/05-059.1.

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9

Warwick, Clifford, Catrina Steedman, and Tricia Holford. "Rattlesnake collection drives—their implications for species and environmental conservation." Oryx 25, no. 1 (1991): 39–44. http://dx.doi.org/10.1017/s0030605300034050.

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Every year large numbers of rattlesnakes (Crotalus spp. and Sistrurus spp.) are collected from the wild in several states in North America. Some of these are collected purely for commercial reasons while others are collected for the traditional, although now largely commercial, ‘rattlesnake round-ups’. Together these activities may remove 300,000–500,000 snakes each year. The high level of hunting together with capture procedures that destroy habitat as well as snakes are damaging rattlesnake populations, other species, and habitat quality.
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10

Whitford, Malachi D., Grace A. Freymiller, Timothy E. Higham, and Rulon W. Clark. "The effects of temperature on the defensive strikes of rattlesnakes." Journal of Experimental Biology 223, no. 14 (2020): jeb223859. http://dx.doi.org/10.1242/jeb.223859.

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ABSTRACTMovements of ectotherms are constrained by their body temperature owing to the effects of temperature on muscle physiology. As physical performance often affects the outcome of predator–prey interactions, environmental temperature can influence the ability of ectotherms to capture prey and/or defend themselves against predators. However, previous research on the kinematics of ectotherms suggests that some species may use elastic storage mechanisms when attacking or defending, thereby mitigating the effects of sub-optimal temperature. Rattlesnakes (Crotalus spp.) are a speciose group of
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11

Tokarnia, Carlos Hubinger, Marilene Farias Brito, José Diomedes Barbosa, and Jürgen Döbereiner. "Quadros clínico-patológicos do envenenamento ofídico por Crotalus durissus terrificus e Bothrops spp. em animais de produção." Pesquisa Veterinária Brasileira 34, no. 4 (2014): 301–12. http://dx.doi.org/10.1590/s0100-736x2014000400001.

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Foi realizada uma revisão dos quadros clínico-patológicos causados pelos venenos de Crotalus durissus terrificus e Bothrops spp. em bovinos, búfalos, ovinos equinos e suínos. Foram compilados os dados obtidos pela experimentação em animais de produção encontrados na literatura e os obtidos através de experimentação realizada por nossa equipe. Também foram revisados os casos naturais de envenenamento ofídico comunicados. Em dois Quadros foram lançados os mais importantes dados dessas revisões, que revelou diversos aspectos interessantes: 1) em nossos experimentos, o veneno de Crotalus durissus
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12

Biondi, Ilka, Dulcineia Ferreira de Andrade, Jaqueline Braga, et al. "Brazilian monospecific anti-crotalic serum does not neutralize the systemic inflammatory response syndrome (SIRS) and the disseminated intravascular coagulation (DIC) induced by Crotalus spp. snake venom from Bahia, Brazil." Toxicon 119 (September 2016): 372. http://dx.doi.org/10.1016/j.toxicon.2016.06.027.

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13

Clark, Rulon W., Sean Tangco, and Matthew A. Barbour. "Field video recordings reveal factors influencing predatory strike success of free-ranging rattlesnakes (Crotalus spp.)." Animal Behaviour 84, no. 1 (2012): 183–90. http://dx.doi.org/10.1016/j.anbehav.2012.04.029.

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14

Rodrigues, T. C. S., A. L. Q. Santos, A. M. C. Lima, D. O. Gomes, and V. L. C. Brites. "Anti- Leptospira spp. antibodies in Crotalus durissus collilineatus kept in captivity and its zoonotic relevance." Acta Tropica 158 (June 2016): 39–42. http://dx.doi.org/10.1016/j.actatropica.2016.02.006.

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15

Canelli, Amanda Pissinatti, Taís Fernanda dos Santos Rodrigues, Vivian Fernandes Furletti de Goes, Guilherme Ferreira Caetano, and Maurício Ventura Mazzi. "Evaluation of the Effectiveness of Crotoxin as an Antiseptic against Candida spp. Biofilms." Toxins 12, no. 9 (2020): 532. http://dx.doi.org/10.3390/toxins12090532.

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The growing number of oral infections caused by the Candida species are becoming harder to treat as the commonly used antibiotics become less effective. This drawback has led to the search for alternative strategies of treatment, which include the use of antifungal molecules derived from natural products. Herein, crotoxin (CTX), the main toxin of Crotalus durissus terrificus venom, was challenged against Candida tropicalis (CBS94) and Candida dubliniensis (CBS7987) strains by in vitro antimicrobial susceptibility tests. Minimum inhibitory concentration (MIC), minimum fungicidal concentration (
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16

Dal Mas, Caroline, Luana Rossato, Thaís Shimizu, et al. "Effects of the Natural Peptide Crotamine from a South American Rattlesnake on Candida auris, an Emergent Multidrug Antifungal Resistant Human Pathogen." Biomolecules 9, no. 6 (2019): 205. http://dx.doi.org/10.3390/biom9060205.

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Invasive Candida infections are an important growing medical concern and treatment options are limited to a few antifungal drug classes, with limited efficacies depending on the infecting organism. In this scenario, invasive infections caused by multiresistant Candida auris are emerging in several places around the world as important healthcare-associated infections. As antimicrobial peptides (AMPs) exert their activities primarily through mechanisms involving membrane disruption, they have a lower chance of inducing drug resistance than general chemical antimicrobials. Interestingly, we previ
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17

Moço, T. C. "Hepatozoon spp. (Hepatozoidae) prevalence in snakes: Morphological, morphometrical and molecular characterization in Crotalus durissus terrificus (Viperidae) naturally infected." Journal of Venomous Animals and Toxins including Tropical Diseases 14, no. 3 (2008): 554. http://dx.doi.org/10.1590/s1678-91992008000300017.

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18

MIYAMOTO, M., and M. MELLO. "Chromatin supraorganization, DNA fragmentation, and cell death in erythrocytes of the rattlesnake, Crotalus durissus terrificus (Serpentes, Viperidae), infected with the protozoan, Hepatozoon spp. (Apicomplexa, Hepatozoidae)." Cell Biology International 31, no. 5 (2007): 494–99. http://dx.doi.org/10.1016/j.cellbi.2006.11.026.

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19

Zacariotti, R., M. Guimarães, T. Jensen, and B. Durrant. "117 CRYOPRESERVATION OF SNAKE SEMEN: ARE WE FROZEN IN TIME?" Reproduction, Fertility and Development 24, no. 1 (2012): 171. http://dx.doi.org/10.1071/rdv24n1ab117.

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The increasing number of endangered snake species, isolation of small fragmented populations with associated inbreeding and mating or conception problems in captivity underscore the need to develop assisted reproductive techniques such as semen cryopreservation and artificial insemination to enhance conservation efforts. However, no efficient protocols for semen evaluation, cooling, or freezing are described in the 4 known publications on snake semen cryopreservation. In this initial study, semen was collected noninvasively from 4 live adult red diamond rattlesnakes (Crotalus ruber) by ventral
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20

Machado, Mizael, Clarice Ricardo De Macêdo Pessoa, André Flávio Almeida Pessoa, et al. "South American Rattlesnake (Crotalus durissus spp.) Envenomation in Dogs in the Semiarid Region of Brazil." Acta Scientiae Veterinariae 48 (July 19, 2020). http://dx.doi.org/10.22456/1679-9216.104578.

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Background: South American rattlesnake (Crotalus durissus spp.) envenomation is rarely reported in small animals and livestock in Brazil. Minor swelling at the snakebite site, skeletal muscle, and renal damage, and severe neurological signs characterize the crotalic envenomation. This case report aims to present epidemiological, clinical, and pathological data of two cases of Crotalus durissus spp envenomation in dogs in the Northeast of Brazil.Cases: Envenomation by Crotalus durissus spp. was recorded in two dogs in Patos, State of Paraíba, Brazil. In Case 1, the dog presented flaccid paralys
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21

Holding, Matthew L., Michael G. Sovic, Timothy J. Colston, and H. Lisle Gibbs. "The scales of coevolution: comparative phylogeography and genetic demography of a locally adapted venomous predator and its prey." Biological Journal of the Linnean Society, December 21, 2020. http://dx.doi.org/10.1093/biolinnean/blaa192.

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Abstract Coevolutionary theory predicts that differences in the genetic demography of interacting species can influence patterns of local adaptation by affecting the potential of local populations to respond to selection. We conducted a comparative phylogeographical study of venomous rattlesnakes and their venom-resistant ground squirrel prey across California, and assessed how effective population size (Ne) estimates correspond with a previously documented pattern of rattlesnake local adaptation. Using RAD sequencing markers, we detected lineage relationships among both the rattlesnakes (Crot
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22

Whitford, M. D., G. A. Freymiller, T. E. Higham, and R. W. Clark. "The Effects of Temperature on the Kinematics of Rattlesnake Predatory Strikes in Both Captive and Field Environments." Integrative Organismal Biology 2, no. 1 (2020). http://dx.doi.org/10.1093/iob/obaa025.

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Abstract The outcomes of predator–prey interactions between endotherms and ectotherms can be heavily influenced by environmental temperature, owing to the difference in how body temperature affects locomotor performance. However, as elastic energy storage mechanisms can allow ectotherms to maintain high levels of performance at cooler body temperatures, detailed analyses of kinematics are necessary to fully understand how changes in temperature might alter endotherm–ectotherm predator–prey interactions. Viperid snakes are widely distributed ectothermic mesopredators that interact with endother
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23

Gomez-Puerta, L. A., L. Baselly, M. T. Lopez-Urbina, A. E. Gonzalez, and P. Mayor. "Visceral infection by Porocephalus spp. (Pentastomida) in Neotropical wild mammals." Journal of Helminthology 94 (2020). http://dx.doi.org/10.1017/s0022149x20000231.

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Abstract Larval stages of pentastomids were collected from different organs of small mammals from the Peruvian Amazon. These parasitized mammals included: a western Amazonian oryzomys (Hylaeamys perenensis), an elegant oryzomys (Euryoryzomys nitidus), a lowland paca (Cuniculus paca), two kinkajous (Potos flavus), two silvery woolly monkeys (Lagothrix poeppigii) and a brown-mantled tamarin (Leontocebus fuscicollis). Pentastomids were found in the mesentery and parenchyma of the liver and lungs of these animals. All pentastomids were morphologically identified as nymphs of Porocephalus spp. Only
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