Log in

Relevant bibliographies by topics / CRSwP / Journal articles

To see the other types of publications on this topic, follow the link: CRSwP.

Journal articles on the topic 'CRSwP'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'CRSwP.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Hervochon, Rémi, Natacha Teissier, Jean-Robert Blondeau, et al. "Computed Tomography Description of the Uncinate Process Angulation in Patients With Cystic Fibrosis and Comparison With Primary Ciliary Dyskinesia, Nasal Polyposis, and Controls." Ear, Nose & Throat Journal 98, no. 2 (2019): 89–93. http://dx.doi.org/10.1177/0145561319828645.

Full text

Abstract:

Background: There is a medial bulging of the lateral nasal wall in patients with cystic fibrosis (CF). Aims: Uncinate process (UP) angulation measurements in patients and controls to objectify this bulging. Materials and Methods: Thirty CF, 17 primary ciliary dyskinesia (PCD), 13 chronic rhinosinusitis with polyps (CRSwp), and 30 controls were included. Angles were measured bilaterally on computed tomography (CT) scans: A, B, C on coronal sections, D and E on axial sections. Angle A was between the UP and the orbit inner wall, whereas the others were between UP and midline. Results: There was

APA, Harvard, Vancouver, ISO, and other styles

2

Prashant, Kumar, and Kumar Jha Gopal. "Comparative Study on Outcomes of Medical Management versus Combined Surgical and Medical Management of Chronic Rhinosinusitis with Polyps: A Retrospective Cohort Study." International Journal of Pharmaceutical and Clinical Research 15, no. 9 (2023): 678–83. https://doi.org/10.5281/zenodo.11356205.

Full text

Abstract:

<strong>Background:</strong> The clinical therapy of chronic rhinosinusitis with polyps (CRSwP) comes with difficulties. To inform treatment decisions based on evidence, this retrospective study compares medical management results to those of a combination of surgical and medical management for CRSwP. <strong>Methods:</strong> The data included 350 individuals with CRSwP, 190 with medical care and 160 receiving combination management. Clinical results, methods of treatment, and patient demographics were analyzed. Descriptive as well as inferential statistics were used. <str

APA, Harvard, Vancouver, ISO, and other styles

3

Scott, John R., Hannah M. J. Ernst, Brian W. Rotenberg, Luke Rudmik, and Leigh J. Sowerby. "Oral Corticosteroid Prescribing Habits for Rhinosinusitis: The American Rhinologic Society Membership." American Journal of Rhinology & Allergy 31, no. 1 (2017): 22–26. http://dx.doi.org/10.2500/ajra.2017.31.4396.

Full text

Abstract:

Background In the field of otolaryngology, oral corticosteroids (OCS) are widely prescribed for rhinosinusitis. Although there is evidence in the literature regarding specific OCS dosing protocols, it is not known to what extent these recommendations are being followed. Objective To examine the current state of OCS prescribing habits for rhinosinusitis by American Rhinologic Society members. Methods An anonymous online survey was sent to all American Rhinologic Society members. Dosing, frequency, tapering, and overall prescribing habits for OCS were assessed in chronic rhinosinusitis with poly

APA, Harvard, Vancouver, ISO, and other styles

4

Van Crombruggen, Koen, Thomas Vogl, Claudina Pérez-Novo, Gabriele Holtappels, and Claus Bachert. "Differential release and deposition of S100A8/A9 proteins in inflamed upper airway tissue." European Respiratory Journal 47, no. 1 (2015): 264–74. http://dx.doi.org/10.1183/13993003.00159-2015.

Full text

Abstract:

Intracellular Ca2+-binding S100A8/A9 proteins gain novel functions when released during inflammation. The exact outcome of their extracellular function depends on the local tissue environment in which they are released; both anti-inflammatory and pro-inflammatory responses are described, modulating the immune system by binding Toll-like receptor (TLR)-4 or the receptor for advanced glycation end-products (RAGE). However, the contribution of the proteins in the pathophysiology of chronic rhinosinusitis (CRS) remains unclear.Homomeric S100A8 and S100A9, and heteromeric S100A8/A9 proteins were ev

APA, Harvard, Vancouver, ISO, and other styles

5

D’Aiuto, Valentina, Ilaria Mormile, Francescopaolo Granata, et al. "Eosinophilic Patterns in Patients with Seasonal Allergy Affected by Bronchial Asthma and Rhinitis/Rhinosinusitis: Efficacy of Benralizumab in Patients with the Persistent Pattern." Journal of Clinical Medicine 13, no. 3 (2024): 754. http://dx.doi.org/10.3390/jcm13030754.

Full text

Abstract:

Background: Eosinophilia can be influenced by multiple factors. This study aims to set a protocol for monitoring blood absolute eosinophil count (AEC) in patients with seasonal allergy affected by bronchial asthma (BA), allergic rhinitis (AR), or chronic rhinosinusitis with or without nasal polyposis (CRSw/sNP). Methods: We planned a total of four annual blood samples to measure AEC in- and out-seasonal pollen exposure (i.e., one measurement every three months for one year). Results: We identified two distinct groups of patients (non-eosinophilic and eosinophilic). Patients in the eosinophilic

APA, Harvard, Vancouver, ISO, and other styles

6

Jura-Szoltys, Edyta, Aleksandra Niemiec-Gorska, Joanna Glȕck, et al. "Results of personalized biological therapy in patients with chronic rhinosinusitis with nasal polyps and severe uncontrolled bronchial asthma – real-life study." Otolaryngologia Polska 79, no. 2 (2025): 1–6. https://doi.org/10.5604/01.3001.0054.9674.

Full text

Abstract:

<b>Introduction:</b> Severe asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) are frequently comorbid diseases caused by type 2 inflammation. The complete etiology of these forms still remains unexplained, which makes causal and fully effective therapeutic management impossible. New therapeutic options using the knowledge of Th2 inflammatory endotype are based on anti-IL5 (mepolizumab, reslizumab), anti-IL5R (benralizumab), anti-IgE (omalizumab), and anti-IL4/IL13 (dupilumab) monoclonal antibodies. Recently, biological therapy has provided a new personalized therapeutic

APA, Harvard, Vancouver, ISO, and other styles

7

Saghari, Abolfazl, Mojtaba Saneie, and Khosrow Hosseini. "Experimental study of one- and two-cycle trapezoidal piano-key side weirs in a curved channel." Water Supply 19, no. 6 (2019): 1597–603. http://dx.doi.org/10.2166/ws.2019.029.

Full text

Abstract:

Abstract Piano-key weirs can be used instead of classic rectangular side-weirs (CRSWs) to increase the discharge capacity of side weirs. So far, no research has been done on trapezoidal piano-key side weirs (TPKSWs) in a curved channel. This study examines the effect of using one or two cycles in TPKSWs on discharge capacity, having the same total width and upstream–downstream length. Dimensional analysis has been performed to determine the dimensionless parameters affecting the discharge coefficient related to the developed length (CdL) of TPKSWs in a curved channel. An empirical equation for

APA, Harvard, Vancouver, ISO, and other styles

8

Arevalo, E., D. A. Holder, J. N. Derr, et al. "Caprine microsatellite dinucleotide repeat polymorphisms at the SR-CRSP-1, SR-CRSP-2, SR-CRSP-3, SR-CRSP-41 and SR-CRSP-5 loci." Animal Genetics 25, no. 3 (2009): 202. http://dx.doi.org/10.1111/j.1365-2052.1994.tb00124.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Bhebhe, E., J. Kogi, D. A. Holder, et al. "Caprine microsatellite dinucleotide repeat polymorphisms at the SR-CRSP-6, SR-CRSP-7, SR-CRSP-8, SR-CRSP-9 and SR-CRSP-10 loci." Animal Genetics 25, no. 3 (2009): 203. http://dx.doi.org/10.1111/j.1365-2052.1994.tb00125.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Kogi, J., C. C. Yeh, B. M. Bhebhe, et al. "Caprine microsatellite dinucleotide repeat polymorphisms at the SR-CRSP-11, SR-CRSP-12, SR-CRSP-13, SR-CRSP-14 and SR-CRSP-15 loci." Animal Genetics 26, no. 6 (2009): 449. http://dx.doi.org/10.1111/j.1365-2052.1995.tb02705.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Forster, U., S. Strathmann, D. Schafer, A. J. Szczepek, and H. Olze. "Eicosanoid imbalance correlates in vitro with the pattern of clinical symptoms of Samter's triad." Rhinology journal 51, no. 1 (2013): 61–69. http://dx.doi.org/10.4193/rhino12.117.

Full text

Abstract:

Background: Hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs) is often associated with chronic rhinosinusitis (CRS), nasal polyps (CRSwNP) and asthma, together known as Samter's triad. The disease is characterised by eicosanoid imbalance. In our study, we determined clinical and laboratory parameters in respect of three groups of patients: 1) CRSwNP, 2) CRSwNP and asthma (CRSwNP-A), and 3) CRSwNP with asthma and NSAID-triggered hypersensitivity (CRSwNP-AA). Our main goal was to improve the characterisation of the stages of development in Samter's triad, pointing to the homogen

APA, Harvard, Vancouver, ISO, and other styles

12

Peng, Yang, Xiao-Xue Zi, Teng-Fei Tian, et al. "Whole-transcriptome sequencing reveals heightened inflammation and defective host defence responses in chronic rhinosinusitis with nasal polyps." European Respiratory Journal 54, no. 5 (2019): 1900732. http://dx.doi.org/10.1183/13993003.00732-2019.

Full text

Abstract:

IntroductionThe pathways underlying chronic rhinosinusitis with nasal polyps (CRSwNP) are unclear. We conducted genome-wide gene expression analysis to determine pathways and candidate gene sets associated with CRSwNP.MethodsWe performed whole-transcriptome RNA sequencing on 42 polyp (CRSwNP-NP) and 33 paired nonpolyp inferior turbinate (CRSwNP-IT) tissues from patients with CRSwNP and 28 inferior turbinate samples from non-CRS controls (CS-IT). We analysed the differentially expressed genes (DEGs) and the gene sets that were enriched in functional pathways.ResultsPrincipal component-informed

APA, Harvard, Vancouver, ISO, and other styles

13

Huriyati, Effy, Eryati Darwin, Yanwirasti Yanwirasti, and Irza Wahid. "Differences in Expression of Inflammatory Mediator in Mucosal and Polyp Tissue between Chronic Rhinosinusitis and Recurrent Chronic Rhinosinusitis." Open Access Macedonian Journal of Medical Sciences 7, no. 11 (2019): 1733–38. http://dx.doi.org/10.3889/oamjms.2019.341.

Full text

Abstract:

BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) remains a challenging clinical entity with its propensity for recurrence. This disease decreases the patients’ quality of life and creates a high economic burden. An effort to investigate the aetiology of recurrent polyps have to be more alert. AIM: This study aims to prove the differences in expression of IL-5, IL-8, IL-17A and TGF-β1 in mucosal and polyp tissue between CRSwNP and recurrent CRSwNP and also to determine which expression of cytokines that have the main role in mucosal and polyp tissue in recurrent CRSwNP.

APA, Harvard, Vancouver, ISO, and other styles

14

Chen, Chongjia C., and Kathleen M. Buchheit. "Endotyping Chronic Rhinosinusitis with Nasal Polyps: Understanding Inflammation Beyond Phenotypes." American Journal of Rhinology & Allergy 37, no. 2 (2023): 132–39. http://dx.doi.org/10.1177/19458924221149003.

Full text

Abstract:

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogenous group of inflammatory conditions impacting the nose and paranasal sinuses. Our understanding of the underlying pathobiology of CRSwNP has substantially improved due to ongoing translational research efforts. Advances in treatment options, including targeted respiratory biologic therapy for CRSwNP, allow for more personalized approaches for CRSwNP patient care. Patients with CRSwNP are typically classified to one or more endotype based on the presence of type 1, type 2, and type 3 inflammation. This review will discuss recent a

APA, Harvard, Vancouver, ISO, and other styles

15

Matsui, Kentaro, Ken Inada, Kenichi Kuriyama, et al. "Prevalence of Circadian Rhythm Sleep-Wake Disorder in Outpatients with Schizophrenia and Its Association with Psychopathological Characteristics and Psychosocial Functioning." Journal of Clinical Medicine 10, no. 7 (2021): 1513. http://dx.doi.org/10.3390/jcm10071513.

Full text

Abstract:

The prevalence of circadian rhythm sleep-wake disorder (CRSWD) among patients with schizophrenia is not clear. The effect of comorbid CRSWD on such patients has also not been fully evaluated yet. Outpatients with schizophrenia in the maintenance phase who visited Tokyo Women’s Medical University Hospital between April 2018 and March 2019 participated in this study. The Brief Psychiatric Rating Scale (BPRS), the Clinical Global Impressions–Severity Illness Scale (CGI-S), Global Assessment of Functioning (GAF), World Health Organization Disability Assessment Schedule II, Insomnia Severity Index

APA, Harvard, Vancouver, ISO, and other styles

16

Zhang, Fang, Zhenhang Xu, Xi He, Yi Sun, Chong Zhao, and Jianhui Zhang. "Increased B Cell-Activating Factor Expression Is Associated with Postoperative Recurrence of Chronic Rhinosinusitis with Nasal Polyps." Mediators of Inflammation 2022 (April 8, 2022): 1–11. http://dx.doi.org/10.1155/2022/7338692.

Full text

Abstract:

Background. Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common upper airway inflammatory disease with a high postoperative recurrence rate. This study is aimed at exploring the expression of B cell-activating factor (BAFF) in CRSwNP and its association with postoperative recurrence. Methods. A total of 80 CRSwNP patients, including 40 primary CRSwNP patients and 40 recurrent CRSwNP patients, 40 chronic rhinosinusitis without nasal polyps (CRSsNP) patients, and 40 healthy controls (HC) were enrolled in this study, and the serum and tissue samples were collected. The circulating and t

APA, Harvard, Vancouver, ISO, and other styles

17

Savlevich, E. L., M. E. Dyneva, L. E. Gaganov, V. I. Egorov, A. N. Gerasimov, and O. M. Kurbacheva. "Diagnostic and treatment algorithm for different phenotypes of chronic rhinosinusitis with nasal polyps." Russian Journal of Allergy 16, no. 2 (2019): 50–60. http://dx.doi.org/10.36691/rja1198.

Full text

Abstract:

Chronic rhinosinusitis with nasal polyps (CRSwNP) may vary in clinical manifestations and can often be associated with a number of comorbid diseases. For a practitioner it is important to forecast the development of the disease, evaluate the risk of relapse and select the most efficient method of treatment in each clinical case. At present, there are no standardized and validated diagnostic biomarkers that could be used as predictors of CRSwNP clinical course. Purpose of the study: to develop diagnostic and treatment algorithm for varies CRSwNP phenotypes based on clinical and laboratory param

APA, Harvard, Vancouver, ISO, and other styles

18

Fessler, Beate. "CRSwNP: Biologikum statt Kortikosteroide." HNO Nachrichten 54, no. 6 (2024): 53. https://doi.org/10.1007/s00060-024-9262-1.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Fath, Roland. "CRSwNP: Paradigmenwechsel durch Biologikatherapie." HNO Nachrichten 53, no. 3 (2023): 50. http://dx.doi.org/10.1007/s00060-023-8611-9.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Bauer-Delto, Angelika. "CRSwNP: Biologika im Vergleich." HNO Nachrichten 55, no. 2 (2025): 57. https://doi.org/10.1007/s00060-025-9349-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Wang, Xueping, Xiaoyuan Zhu, Li Peng, and Yulin Zhao. "Identification of lncRNA Biomarkers and LINC01198 Promotes Progression of Chronic Rhinosinusitis with Nasal Polyps through Sponge miR-6776-5p." BioMed Research International 2022 (May 6, 2022): 1–27. http://dx.doi.org/10.1155/2022/9469207.

Full text

Abstract:

Background. Chronic sinusitis (CRS) was a chronic inflammation that originated in the nasal mucosa and affected the health of most people around the world. Chronic rhinosinusitis with nasal polyps (CRSwNP) was one kind of chronic sinusitis. Emerging research had suggested that long noncoding RNAs (lncRNAs) played vital parts in inflammatories and inflammation development. Methods. We acquired GEO data to analyze the differential expression between the miRNA, immune genes, TF, and lncRNA data in CRSWNP and the corresponding control tissues. Bioinformatic analysis by coexpression of endogenous R

APA, Harvard, Vancouver, ISO, and other styles

22

Kurbacheva, Oksana Mikhailovna, Miramgul Esengeldyevna Dyneva, Igor Petrovich Shilovskii, et al. "Polypous rhinosinusitis in combination with bronchial asthma: clinical features and cellular characteristics of local and systemic inflammation." Russian Journal of Allergy 17, no. 1 (2020): 32–49. http://dx.doi.org/10.36691/raj.2020.17.1.003.

Full text

Abstract:

Background. The combination of chronic rhinosinusitis with nasal polyps (CRSwNP) and bronchial asthma (BA) is currently considered as a separate phenotype characterized by similar features of inflammatory changes leading to an increase in the clinical course of both CRSwNP and BA. The aim of the study was to investigate the clinical features and characteristics of the local and systemic inflammatory process in patients having a combination of CRSwNP and BA. Materials and methods. The study included 96 volunteers, who were divided into 4 groups: group 1 consisted of healthy volunteers (Normal);

APA, Harvard, Vancouver, ISO, and other styles

23

Xu, Qingqing, Kun Du, Ming Zheng, et al. "Application of Clinical Scores in the Differential Diagnosis of Chronic Rhinosinusitis With Nasal Polyps in a Chinese Population." American Journal of Rhinology & Allergy 34, no. 3 (2020): 401–8. http://dx.doi.org/10.1177/1945892420901996.

Full text

Abstract:

Background Eosinophilic (Eos) and non-eosinophilic (non-Eos) chronic rhinosinusitis with nasal polyps (CRSwNP) react differently to clinical treatment, with eosinophilic chronic rhinosinusitis with nasal polyps (Eos CRSwNP) being more likely to recur after surgery. Objective To explore the clinical value of the visual analog scale (VAS), nasal endoscopy score (Lund–Kennedy, L–K), computed tomography (CT) score (Lund–Mackay scoring system, L–M), and blood Eos percentage in the differential diagnosis of Eos CRSwNP and non-Eos CRSwNP. Methods Ninety-nine patients with CRSwNP were enrolled in this

APA, Harvard, Vancouver, ISO, and other styles

24

Deng, Zhenghao, Zhi Li, Yongchuan She, and Bin Xie. "Increased Expression of SERPINB10 Associated with Postoperative Recurrence in Chronic Rhinosinusitis with Nasal Polyps." Disease Markers 2022 (November 8, 2022): 1–10. http://dx.doi.org/10.1155/2022/7164318.

Full text

Abstract:

Background. Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common upper airway inflammatory disorder with a high rate of postoperative recurrence. SERPINB10 is a proinflammatory cytokine expressed on epithelial cells, but its role in CRSwNP has not been described. This study is aimed at exploring the SERPINB10 expression in CRSwNP and its relationship with postoperative recidivation. Methods. We recruited 140 individuals, consisting of 60 patients with CRSwNP, 40 patients with chronic rhinosinusitis without nasal polyps (CRSsNP), and 40 healthy controls (HCs). Tissue specimens were col

APA, Harvard, Vancouver, ISO, and other styles

25

Lei, Chenyang, Juan Jiang, Yanyan Zhang, and Gaoyun Xiong. "Role and Function of Regulatory T Cell in Chronic Rhinosinusitis with Nasal Polyposis." Journal of Immunology Research 2022 (March 26, 2022): 1–12. http://dx.doi.org/10.1155/2022/1144563.

Full text

Abstract:

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a subtype of chronic rhinosinusitis characterized by high edema in the stroma, albumin deposition, and formation of pseudocysts. The pathogenesis of CRSwNP is not yet fully understood. Regulatory T (Treg) cells are a subset of CD4+ T cells that play a suppressive immunoregulatory role in the process of CRSwNP. Recent studies have found that there was a significant reduction in Treg cells in polyp tissues, which leads to the onset of CRSwNP. An imbalance between Th17 and Treg cells can also aggravate inflammation toward the Th2 type. This rev

APA, Harvard, Vancouver, ISO, and other styles

26

Peters, Anju T., Lindsay G. S. Bengtson, Yen Chung, et al. "Clinical and economic burden of chronic rhinosinusitis with nasal polyposis: A U.S. administrative claims analysis." Allergy and Asthma Proceedings 43, no. 5 (2022): 435–45. http://dx.doi.org/10.2500/aap.2022.43.220048.

Full text

Abstract:

Background: Limited data exist on the clinical and economic burden of chronic rhinosinusitis with nasal polyposis (CRSwNP). Objective: To describe patient characteristics, health-care resource utilization (HCRU), and health-care costs among patients with CRSwNP with and without comorbid asthma (primary analysis) and with surgical management of nasal polyps (secondary analysis). Methods: This was a retrospective study of patients diagnosed with CRSwNP conducted using administrative claims data from January 1, 2013, through March 31, 2019. Study outcomes were assessed over a 2-year follow-up. Re

APA, Harvard, Vancouver, ISO, and other styles

27

Istratenco, Ala. "Oxidative stress-related pathophysiology in chronic rhinosinusitis with nasal polyps: research challenges." Romanian Journal of Rhinology 9, no. 34 (2019): 71–77. http://dx.doi.org/10.2478/rjr-2019-0008.

Full text

Abstract:

Abstract Chronic rhinosinusitis with nasal polyps (CRSwNP) is considered a multifactorial pathology with negative impact on the quality of life and considerable socio-economic effects. The pathogenesis of CRSwNP has not yet been fully elucidated despite remarkable studies in this field. This limits the pathogenic treatment and, therefore, the pathological process is expressed by a greater tendency of recurrence. Patients with recurrent CRSwNP remain in a severe state and therapeutically uncontrolled. In recent studies, the involvement of oxidative stress (OS) in the pathogenesis of CRSwNP has

APA, Harvard, Vancouver, ISO, and other styles

28

Zhou, Xuanchen, Xiaoyue Zhen, Yiqing Liu, et al. "Identification of Key Modules, Hub Genes, and Noncoding RNAs in Chronic Rhinosinusitis with Nasal Polyps by Weighted Gene Coexpression Network Analysis." BioMed Research International 2020 (January 25, 2020): 1–20. http://dx.doi.org/10.1155/2020/6140728.

Full text

Abstract:

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory disease with relatively easy recurrence. However, the precise molecular mechanisms of this disease are poorly known. Based on gene sequencing data obtained from the Gene Expression Omnibus (GEO) database, we constructed coexpression networks by weighted gene coexpression network analysis (WGCNA). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed by the Database for Annotation, Visualization, and Integrated Discovery (DAVID). The core gene of pathogenesis, CRSwNP, w

APA, Harvard, Vancouver, ISO, and other styles

29

Kurbacheva, O. M., M. E. Dyneva, I. P. Shilovskiy, et al. "Pathogenetic molecular mechanisms of chronic rhinosinusitis with nasal polyps associated with asthma." PULMONOLOGIYA 31, no. 1 (2021): 7–19. http://dx.doi.org/10.18093/0869-0189-2021-31-1-7-19.

Full text

Abstract:

The combination of bronchial asthma (BA) and chronic rhinosinusitis with nasal polyps (CRSwNP) is currently considered a separate phenotype wit1 dysregulation of pro- and anti-inflammatory cytokines as one of t1e leading causes of inflammation. The aim of this study was to investigate the local and systemic inflammatory process in patients with BA associated with CRSwNP. Methods. The study enrolled 96 volunteers divided into 4 groups: the 1st was healthy control (Normal); the 2nd had allergic BA associated with CRSwNP; the 3rd had nonallergic BA associated with CRSwNP; the 4th had CRSwNP witho

APA, Harvard, Vancouver, ISO, and other styles

30

Aflitonov, M. A., S. A. Artyushkin, S. A. Partsernyak, et al. "VERIFICATION AND TREATMENT OF RESISTANT CHRONIC RHINOSINUSITIS WITH NASAL POLYPS AT MULTIMORBID CARDIOVASCULAR PATHOLOGY." HERALD of North-Western State Medical University named after I.I. Mechnikov 9, no. 2 (2017): 90–96. http://dx.doi.org/10.17816/mechnikov20179290-96.

Full text

Abstract:

Objective: Identify the diagnostic signs for chronic rhinosinusitis with nasal polyps (CRSwNP & resistant forms) with multimorbid cardiovascular pathology (MCVP) (coronary artery disease (CAd), hypertension, metabolic syndrome (MS). Identify effectiveness of photodynamic therapy in CRSwNP treatment. Design and methods: The study included 75 patients (mean age 35,8±7,93, 39,2% - female,60,8% - male) with CRSwNP and MCVP divided into 3 groups by simple random sampling. Patients in group 1 (n = 27) received standard therapy CRSwNP, hypertension, CAd, NPMd, 8-weeks anti- bacterial and leukotri

APA, Harvard, Vancouver, ISO, and other styles

31

Talat, Rehab, Marlene M. Speth, Isabelle Gengler, et al. "Chronic Rhinosinusitis Patients With and Without Polyps Experience Different Symptom Perception and Quality of Life Burdens." American Journal of Rhinology & Allergy 34, no. 6 (2020): 742–50. http://dx.doi.org/10.1177/1945892420927244.

Full text

Abstract:

Objective We sought to determine if chronic rhinosinusitis (CRS) patients with nasal polyps (CRSwNP) differentially perceived CRS symptom burden compared to patients without nasal polyps (CRSsNP) and to what extent CRS symptom severity was associated with quality of life (QOL) and patient-reported symptom control in the 2 groups. Methods A total of 600 patients (266 CRSwNP and 334 CRSsNP) presenting with CRS were recruited. CRS symptom burden was assessed with the 22-item Sinonasal Outcome Test (SNOT-22). SNOT-22 nasal, sleep, ear/facial discomfort, and emotional subdomain scores were calculat

APA, Harvard, Vancouver, ISO, and other styles

32

Yu, Hyunjae, and Dong-Kyu Kim. "Neutrophils Play an Important Role in the Recurrence of Chronic Rhinosinusitis with Nasal Polyps." Biomedicines 10, no. 11 (2022): 2911. http://dx.doi.org/10.3390/biomedicines10112911.

Full text

Abstract:

Despite the heterogeneity of chronic rhinosinusitis (CRS), a clear link exists between type 2 immunity and the severity of CRS with nasal polyps (CRSwNP). However, recent studies have demonstrated that patients with severe type 2 CRSwNP also display abundant neutrophilic inflammation. Therefore, we investigated the factors associated with the recurrence of CRSwNP following sinus surgery using a machine-learning algorithm. We collected the demographics, clinical variables, and inflammatory profiles of 210 patients with CRSwNP who underwent sinus surgery. After one year, we evaluated whether eac

APA, Harvard, Vancouver, ISO, and other styles

33

Klimek, L., H. Olze, U. Förster-Ruhrmann, et al. "Positionspapier: Empfehlungen zur Anwendung von Mepolizumab bei chronischer Rhinosinusitis mit Polyposis nasi (CRSwNP) im deutschen Gesundheitssystem – Empfehlungen des Ärzteverbandes Deutscher Allergologen (AeDA) und der AGs Klinische Immunologie, Allergologie und Umweltmedizin und Rhinologie und Rhinochirurgie der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie (DGHNO-KHC)." Laryngo-Rhino-Otologie 101, no. 04 (2022): 284–94. http://dx.doi.org/10.1055/a-1752-8462.

Full text

Abstract:

Zusammenfassung Hintergrund Die chronische Rhinosinusitis mit Nasenpolypen (CRSwNP) ist eine multifaktorielle entzündliche Erkrankung der paranasalen Schleimhäute, der als häufigstem Endotyp eine eosinophile Inflammation zugrunde liegt. Der Anti-IL-5-Antikörper Mepolizumab wurde im November 2021 für die Therapie der schweren CRSwNP zugelassen. Methoden In einer Literatursuche wurde die Immunologie der CRSwNP analysiert und die vorhandene Evidenz ermittelt durch Recherchen in Medline, PubMed sowie den nationalen und internationalen Studien- und Leitlinien-Registern und der Cochrane Library. Es

APA, Harvard, Vancouver, ISO, and other styles

34

Bandi, Sindhura, Ellen Stephen, Keerthi Bansal, and Mahboobeh Mahdavinia. "Understanding the CRSwNP Patient as Whole." American Journal of Rhinology & Allergy 37, no. 2 (2023): 140–46. http://dx.doi.org/10.1177/19458924231152671.

Full text

Abstract:

Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a distinct inflammatory disease of the upper airways with a significant impact on the health and quality of life of affected patients. Several comorbid conditions such as allergic rhinitis, asthma, sleep disorders, and gastroesophageal reflux disease are commonly reported in patients with CRSwNP. Objective In this article, we intended to review the UpToDate information on how these comorbidities can impact CRSwNP patients’ health and well-being. Methods A PUBMED search was performed to review relevant recent article on the topic.

APA, Harvard, Vancouver, ISO, and other styles

35

Charles, Christopher J., Takeshi Katafuchi, Timothy G. Yandle, and Naoto Minamino. "Identification and biological activity of ovine and caprine calcitonin receptor-stimulating peptides 1 and 2." Journal of Endocrinology 198, no. 2 (2008): 429–37. http://dx.doi.org/10.1677/joe-08-0106.

Full text

Abstract:

We have recently reported the isolation of three new members of the calcitonin (CT) gene-related peptide family of peptides, the CT receptor (CT-R)-stimulating peptides (CRSPs). We now report the sequencing and characterization of ovine/caprine CRSP-1 and caprine CRSP-2. Mature ovine and caprine CRSP-1 are identical and have strong structural homology to CRSP-1s identified to date from other species. As with other CRSP-1s, ovine/caprine CRSP-1 binds to and activates the CT-R but not the CT-like receptor (CL-R) in combination with the receptor activity-modifying proteins (RAMPs). By contrast, c

APA, Harvard, Vancouver, ISO, and other styles

36

Varyushina, E. A., E. V. Bezrukova, E. V. Vorobeychikov, et al. "Study of local inflammatory response in different clinical forms of chronic polypous rhinosinusitis." Medical Immunology (Russia) 24, no. 3 (2022): 539–52. http://dx.doi.org/10.15789/1563-0625-sol-2479.

Full text

Abstract:

Chronic rhinosinusitis (CRS) affects 5-12% of the world’s adult population. Chronic rhinosinusitis with nasal polyps (CRSwNP) accounts for 25-30% of all cases of CRS. CRSwNP-associated inflammatory process in nasal mucosa and paranasal sinuses depends on the characteristics of local immunity, including expression of a number of cytokines. The aim of this work was to investigate the parameters of local immunity in various clinical forms of CRSwNP. In this work, the concentrations of pro-inflammatory cytokines, i.e., interleukin-1β (IL-1β) and IL-8, antimicrobial function of neutrophils from the

APA, Harvard, Vancouver, ISO, and other styles

37

Sonoyama, Toru, Takashi Ishino, Kota Takemoto, et al. "Deep Association between Transglutaminase 1 and Tissue Eosinophil Infiltration Leading to Nasal Polyp Formation and/or Maintenance with Fibrin Polymerization in Chronic Rhinosinusitis with Nasal Polyps." International Journal of Molecular Sciences 23, no. 21 (2022): 12955. http://dx.doi.org/10.3390/ijms232112955.

Full text

Abstract:

Transglutaminase (TGM) isoform catalyze the cross-linking reaction of identical or different substrate proteins. Eosinophil has been recognized in chronic rhinosinusitis with nasal polyps (CRSwNP) forming tissue eosinophil in nasal polyp (NP), and TGM isoforms are suggested to be associated with a critical role in asthma and other allergic conditions. The aim of this study was to reveal the association of specific TGM isoform with both the tissue eosinophil infiltration deeply concerning with the intractable severity of CRSwNP and the fibrin polymerization ability of TGM isoform associated wit

APA, Harvard, Vancouver, ISO, and other styles

38

Wang, Hai, Jia Song, Zhe-zheng Wang, Jian-wen Ruan, and Zheng Liu. "The expression of CD22 and CD72 on B cells negatively correlate with IgE level in eosinophilic chronic rhinosinusitis with nasal polyps." Journal of Immunology 200, no. 1_Supplement (2018): 45.38. http://dx.doi.org/10.4049/jimmunol.200.supp.45.38.

Full text

Abstract:

Abstract Background CD22 and CD72 have been demonstrated to act as B cell inhibitory receptors, which suppress B cells activation. However, the roles of CD22 and CD72 on B cells in nasal polyps (NPs) are largely unknown. Objective To explore the expression of CD22 and CD72 on B cells and the association with immunoglobulins (Igs) in NPs. Methods The expression levels of CD22 and CD72 was measured by RT-PCR, immunohistochemistry, immunofluorescence and flow cytometry. Igs levels in NPs were quantified by Bio-Plex assay or the UniCAP system. Computed tomography scan and symptom severity were gra

APA, Harvard, Vancouver, ISO, and other styles

39

Lyubimova, E. V., E. L. Savlevich, A. V. Zurochka, E. S. Mitrofanova, and O. M. Kurbacheva. "Incidence of coronavirus disease (COVID-19) in patients with different degrees of chronic rhinosinusitis with nasal polyps." Meditsinskiy sovet = Medical Council, no. 9 (June 6, 2024): 168–76. http://dx.doi.org/10.21518/ms2024-094.

Full text

Abstract:

Introduction. Chronic rhinosinusitis with nasal polyps (CRSwNP) pathogenesis is based on inadequate local immune response, additional SARS-CoV-2 infection can alter CRSwNP pathological process.Aim. To effect of COVID-19 on CRSwNP course in patients with different drug control degree.Materials and methods. 99 patients with bilateral CRSwNP (48 men, 51 women, 58.37 ± 14.43 years), were divided into 3 groups based on CRSwNP medical control degree for 5 years [17]. Group 1 (n = 34) – patients with mild CRSwNP received treatment according to treatment algorithm stages I and II. Group 2 (n = 32) – m

APA, Harvard, Vancouver, ISO, and other styles

40

Jeican, Ionuț, Dan Gheban, Lucian Barbu-Tudoran, et al. "Respiratory Nasal Mucosa in Chronic Rhinosinusitis with Nasal Polyps versus COVID-19: Histopathology, Electron Microscopy Analysis and Assessing of Tissue Interleukin-33." Journal of Clinical Medicine 10, no. 18 (2021): 4110. http://dx.doi.org/10.3390/jcm10184110.

Full text

Abstract:

(1) Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is one of the most studied rhinological disorders. Modifications of the respiratory nasal mucosa in COVID-19 patients are so far unknown. This paper presents a comparative morphological characterization of the respiratory nasal mucosa in CRSwNP versus COVID-19 and tissue interleukin (IL)-33 concentration. (2) Methods: We analyzed CRSwNP and COVID-19 samples through histopathology, scanning and transmission electron microscopy and performed proteomic determination of IL-33. (3) Results: Histopathologically, stromal edema (p <

APA, Harvard, Vancouver, ISO, and other styles

41

Qureshi, Hannan A., Zechariah G. Franks, Asiana Gurung, and Murugappan Ramanathan. "Scientific Advancements That Empower Us to Understand CRS Pathophysiology." American Journal of Rhinology & Allergy 37, no. 2 (2023): 221–26. http://dx.doi.org/10.1177/19458924221148026.

Full text

Abstract:

Background Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a multifactorial inflammatory condition that remains poorly understood. Over the past decade, we have witnessed impressive scientific advancements that have allowed us to better understand the molecular and cellular mechanisms that underlie the inflammatory processes in mucosal diseases including asthma, allergic rhinitis, and CRSwNP. Objective The present review aims to summarize and highlight the most recent scientific advancements that have enriched our understanding of CRSwNP. Methods A comprehensive review of the available

APA, Harvard, Vancouver, ISO, and other styles

42

Yoon, HyoungSun, Il-Youp Kwak, KyungSoo Kim, and Hyun Jin Min. "Chronic Rhinosinusitis With Nasal Polyps Does Not Affect the Association Between the Nasal Provocation Test and Serum Allergen-Specific Immunoglobulin E Levels." Journal of Rhinology 31, no. 1 (2024): 29–36. http://dx.doi.org/10.18787/jr.2024.00004.

Full text

Abstract:

Background and Objectives: This study compared nasal provocation test (NPT) results between groups with and without chronic rhinosinusitis with nasal polyps (CRSwNP) to investigate whether CRSwNP affects the response to the intranasal allergen challenge.Methods: We reviewed the medical records of patients who had undergone the NPT, multiple allergen simultaneous test (MAST), and paranasal sinus computed tomography. Patients were diagnosed with CRSwNP based on findings from nasal endoscopy and paranasal sinus computed tomography. The NPT for house dust mites was conducted, and a positive MAST d

APA, Harvard, Vancouver, ISO, and other styles

43

Lin, Yu-Tsai, Ming-Hsien Tsai, Yan-Ye Su, Wei-Chih Chen, Shun-Chen Huang та Chih-Yen Chien. "Expression of Major Lipid Raft Protein Raftlin in Chronic Rhinosinusitis with Nasal Polyps in Smoking and Non-Smoking Patients Correlated with Interleukin-17 and Tumor Necrosis Factor-α Levels". Biomolecules 12, № 9 (2022): 1316. http://dx.doi.org/10.3390/biom12091316.

Full text

Abstract:

Raftlin, as an inflammatory biomarker, has been previously reported in chronic inflammatory diseases. This study investigates the expression of Raftlin in cigarette smokers and in chronic rhinosinusitis with nasal polyps (CRSwNP), as well as evaluating its correlation with interleukin-17 (IL-17) and tumor necrosis factor-α (TNF-α) levels. A total of 30 CRSwNP non-smoking and 16 CRSwNP + SK (smoking) patients undergoing endoscopic sinus surgery were enrolled, while 20 middle turbinate tissue pieces were examined and performed as the control group. In nasal mucosa epithelial staining, Raftlin le

APA, Harvard, Vancouver, ISO, and other styles

44

Parrino, Daniela, Giuseppe Brescia, Claudia Zanotti, et al. "Non-Eosinophilic Chronic Rhinosinusitis With Nasal Polyps: Eosinophil, Basophil, and Neutrophil Blood Counts Before and After Surgery." Annals of Otology, Rhinology & Laryngology 128, no. 3 (2018): 233–40. http://dx.doi.org/10.1177/0003489418818578.

Full text

Abstract:

Objectives: Research selectively investigating non-eosinophilic chronic rhinosinusitis with nasal polyps (CRSwNP) is lacking. The inflammatory patterns seen in non-eosinophilic CRSwNP are still poorly understood. The present study is the first to compare blood eosinophil, basophil, and neutrophil counts before/after surgery in patients with non-eosinophilic CRSwNP stratified by their clinical features. Methods: The study concerned 107 consecutive patients with histologically confirmed non-eosinophilic CRSwNP who underwent endoscopic sinus surgery (ESS). Results: Statistical analysis ruled out

APA, Harvard, Vancouver, ISO, and other styles

45

Soklic, Tanja Kosak, Matija Rijavec, Mira Silar, et al. "Transcription factors gene expression in chronic rhinosinusitis with and without nasal polyps." Radiology and Oncology 53, no. 3 (2019): 323–30. http://dx.doi.org/10.2478/raon-2019-0029.

Full text

Abstract:

Abstract Background Chronic rhinosinusitis (CRS) current therapeutic approaches still fail in some patients with severe persistent symptoms and recurrences after surgery. We aimed to evaluate the master transcription factors gene expression levels of T cell subtypes in chronic rhinosinusitis with nasal polyps (CRSwNP) and chronic rhinosinusitis without nasal polyps (CRSsNP) that could represent new, up-stream targets for topical DNAzyme treatment. Patients and methods Twenty-two newly diagnosed CRS patients (14 CRSwNP and 8 CRSsNP) were prospectively biopsied and examined histopathologically.

APA, Harvard, Vancouver, ISO, and other styles

46

Savlevich, E. L., V. A. Cherenkova, and A. Yu Molodnitskaia. "Basic principles for the treatment of chronic rhinosinusitis with nasal polyps." Meditsinskiy sovet = Medical Council, no. 16 (November 14, 2020): 73–78. http://dx.doi.org/10.21518/2079-701x-2020-16-73-78.

Full text

Abstract:

Introduction. Chronic rhinosinusitis with nasal polyps (CRSwNP) is based on a chronic inflammatory hyperplastic process in the mucosa membrane of the nasal cavity and paranasal sinuses (SNPs). According to the consensus on the biological treatment of CRSwNP with or without asthma, which is one of the latest consensus documents of the European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA), which was published in December 2019, the need for surgical treatment or systemic administration of corticosteroids due to the active nasal polyps growth are conditional signs for

APA, Harvard, Vancouver, ISO, and other styles

47

Qureshi, Hannan A., and Andrew P. Lane. "Olfaction Now and in the Future in CRSwNP." American Journal of Rhinology & Allergy 37, no. 2 (2023): 168–74. http://dx.doi.org/10.1177/19458924231153485.

Full text

Abstract:

Background Chronic rhinosinusitis (CRS) is the leading cause of olfactory dysfunction in the general population. Olfactory dysfunction is more common in patients with CRS with nasal polyposis (CRSwNP) compared to those without polyps. Purpose The present review aims to summarize the current literature on the mechanism behind olfactory dysfunction in CRSwNP and the impact of therapy on olfactory outcomes in this patient population. Methods A comprehensive review of the available literature on olfaction in CRSwNP was performed. We evaluated the most recent evidence from studies on the mechanisms

APA, Harvard, Vancouver, ISO, and other styles

48

Boyle, John V., Kent Lam, and Joseph K. Han. "Dupilumab in the treatment of chronic rhinosinusitis with nasal polyposis." Immunotherapy 12, no. 2 (2020): 111–21. http://dx.doi.org/10.2217/imt-2019-0191.

Full text

Abstract:

Chronic rhinosinusitis with nasal polyposis (CRSwNP) imparts a significant healthcare challenge, resulting in diminished quality of life for patients and high costs with resource utilization for disease management. Understanding of CRSwNP pathophysiology has progressively evolved and the identification of various inflammatory biomarkers has led to the development of monoclonal antibodies that target the underlying mechanisms of inflammation. Dupilumab, which targets IL-4 and IL-13 signaling, serves as a novel agent for CRSwNP treatment. Three clinical trials, NCT01920893, SINUS-24 and SINUS-52

APA, Harvard, Vancouver, ISO, and other styles

49

Zhang, Yanni, Kang Zhu, Jingguo Chen, et al. "Predictive Values of Serum IL-33 and sST2 in Endotypes and Postoperative Recurrence of Chronic Rhinosinusitis with Nasal Polyps." Mediators of Inflammation 2022 (May 19, 2022): 1–9. http://dx.doi.org/10.1155/2022/9155080.

Full text

Abstract:

Background. Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common inflammatory disease with high heterogeneity and postoperative recidivation. The IL-33/ST2 axis is known to be involved in Th2 immune responses. This study is aimed at exploring levels of serum IL-33 and soluble ST2 (sST2) in CRSwNP patients and their potential for predicting CRSwNP endotypes and postoperative recurrence. Methods. The present study recruited 149 CRSwNP patients, 80 of whom were noneosinophilic (neCRSwNP) and 69 eosinophilic (eCRSwNP), as well as 60 healthy controls (HCs). Serum samples were collected fro

APA, Harvard, Vancouver, ISO, and other styles

50

Ference, Elisabeth H., Jeffrey D. Suh, Bruce K. Tan, and Stephanie Shintani Smith. "How Often is Sinus Surgery Performed for Chronic Rhinosinusitis with versus without Nasal Polyps?" American Journal of Rhinology & Allergy 32, no. 1 (2018): 34–39. http://dx.doi.org/10.2500/ajra.2018.32.4495.

Full text

Abstract:

Background There currently are no data on the relative frequency of endoscopic sinus surgeries (ESS) performed for chronic rhinosinusitis with nasal polyposis (CRSwNP) versus chronic rhinosinusitis without nasal polyposis (CRSsNP) in the United States. Objectives To compare the rate of surgical interventions for CRSwNP and CRSsNP. Methods Cases identified by CPT codes were extracted from the 2009–2011 State Ambulatory Surgery Databases for California, Florida, Maryland, and New York. Patient demographics, extent of surgery, mean charges, and operating room (OR) time were compared. Results A to

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!