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Journal articles on the topic 'Cryoprecipitate transfusion'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 February 2022

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1

Nascimento, Barto, Jerrold H. Levy, Homer Tien, and Luis Teodoro Da Luz. "Cryoprecipitate transfusion in bleeding patients." CJEM 22, S2 (2020): S4—S11. http://dx.doi.org/10.1017/cem.2019.409.

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ABSTRACTObjectivesThe management of acquired coagulopathy in multiple clinical settings frequently involves fibrinogen supplementation. Cryoprecipitate, a multidonor product, is widely used for the treatment of acquired hypofibrinogenemia following massive bleeding, but it has been associated with adverse events. We aimed to review the latest evidence on cryoprecipitate for treatment of bleeding.MethodsWe conducted a narrative review of current literature on cryoprecipitate therapy, describing its history, formulations and preparation, and recommended dosing. We also reviewed guideline recomme

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Curry, Nicola, and Henna Wong. "Cryoprecipitate transfusion: current perspectives." International Journal of Clinical Transfusion Medicine Volume 4 (September 2016): 89–97. http://dx.doi.org/10.2147/ijctm.s99042.

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Sandhu, Manpreet K., Trishala Agrawal, Maya Shah, and Alice J. Cohen. "Overuse of Cryoprecipitate: A Chronic Condition,." Blood 118, no. 21 (2011): 4212. http://dx.doi.org/10.1182/blood.v118.21.4212.4212.

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Abstract Abstract 4212 Background: Literature has revealed that there is considerable inappropriate use of blood products including cryoprecipitate (cryo). Appropriate indications for cryo use according to American Association of Blood Banks (AABB) guidelines include bleeding due to hypofibrinogenemia (fibrinogen level < 100mg/dl) or dysfibrinogenemia, factor XIII deficiency, bleeding associated with Hemophilia A or von Willebrand disease (when appropriate factor concentrates are not available) and uremic bleeding (DDAVP preferred). To determine appropriateness of use of cryo at Newark Beth

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Nigam, A., A. Prakash, and P. Saxena. "Blood Transfusion in Obstetrics." Kathmandu University Medical Journal 11, no. 4 (2015): 355–59. http://dx.doi.org/10.3126/kumj.v11i4.13484.

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Transfusion of blood and blood components is a common practice in obstetric wards but it is not without risk. The incidence of transfusion reactions varies from 4 in every hundred transfusions for non-haemolytic reactions to one in every 40,000 for haemolytic transfusion reactions. The physiological basis of blood transfusion is outlined in this article. Most of the donated blood is processed into components: packed red cells (PRBCs), platelets, and fresh frozen plasma (FFP) or cryoprecipitate. Various alternatives to blood transfusion exist and include autotransfusion, pre-autologous blood st

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Kruse, Robert L., Melissa Neally, Brian C. Cho, et al. "Cryoprecipitate Utilization Patterns Observed With a Required Prospective Approval Process vs Electronic Dosing Guidance." American Journal of Clinical Pathology 154, no. 3 (2020): 362–68. http://dx.doi.org/10.1093/ajcp/aqaa042.

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Abstract Objectives We evaluated the impact of electronic medical record (EMR)–guided pooled cryoprecipitate dosing vs our previous practice of requiring transfusion medicine (TM) resident approval for every cryoprecipitate transfusion. Methods At our hospital, cryoprecipitate pooled from five donors is dosed for adult patients, while single-donor cryoprecipitate is dosed for pediatric patients (defined as patients &lt;50 kg in weight). EMR-based dosing guidance replaced a previously required TM consultation when cryoprecipitate pools were ordered, but a consultation remained required for

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Castillo, R., J. Monteagudo, G. Escolar, A. Ordinas, M. Magallon, and J. Martin Villar. "Hemostatic effect of normal platelet transfusion in severe von Willebrand disease patients." Blood 77, no. 9 (1991): 1901–5. http://dx.doi.org/10.1182/blood.v77.9.1901.1901.

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Abstract Platelet von Willebrand factor (vWF) has been suggested to play an important role in the hemostatic process. Clinical and experimental data indicate that bleeding time (BT) and platelet-vessel wall interaction cannot be normalized unless the defect of platelet vWF is also corrected. We have examined the effect of normal platelet concentrate transfusion 1 hour after cryoprecipitate infusion in five type III von Willebrand disease (vWD) patients. The cryoprecipitate infusion attained normal circulating levels of ristocetin cofactor, vWF antigen, and factor VIII activity. In two patients

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Castillo, R., J. Monteagudo, G. Escolar, A. Ordinas, M. Magallon, and J. Martin Villar. "Hemostatic effect of normal platelet transfusion in severe von Willebrand disease patients." Blood 77, no. 9 (1991): 1901–5. http://dx.doi.org/10.1182/blood.v77.9.1901.bloodjournal7791901.

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Platelet von Willebrand factor (vWF) has been suggested to play an important role in the hemostatic process. Clinical and experimental data indicate that bleeding time (BT) and platelet-vessel wall interaction cannot be normalized unless the defect of platelet vWF is also corrected. We have examined the effect of normal platelet concentrate transfusion 1 hour after cryoprecipitate infusion in five type III von Willebrand disease (vWD) patients. The cryoprecipitate infusion attained normal circulating levels of ristocetin cofactor, vWF antigen, and factor VIII activity. In two patients, cryopre

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Karim, Shanaz, Ehteshamul Hoque, Md Mazharul Hoque, Syeda Masooma Rahman, and Kashfia Islam. "Blood Component Therapy." Anwer Khan Modern Medical College Journal 9, no. 2 (2018): 142–47. http://dx.doi.org/10.3329/akmmcj.v9i2.39211.

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Transfusion medicine has undergone advancements since its initiation in the early 20th century. One of these was the discovery that blood can be divided into individual components and delivered separately. Today, blood transfusions nearly always consist of the ad-ministration of 1 or more components of blood. Whole blood transfusion is now limited to situations involving massive resuscitation (trauma ) The most familiar cellular components include packed red blood cells (PRBC), washed PRBC, leukoreduced PRBC and pooled or aphaeresis platelets. Plasma products such as FFP or cryoprecipitate, an

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Serei, Virian, Cecilia Wong, and Grace Tenorio. "Cryoprecipitate Usage and Cost at a Tertiary Care Hospital Between 2010 and 2017." American Journal of Clinical Pathology 152, Supplement_1 (2019): S154. http://dx.doi.org/10.1093/ajcp/aqz131.008.

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Abstract Introduction Cryoprecipitate (CRYO), a blood product prepared from FFP, is rich in fibrinogen, von Willebrand’s factor, and factors VIII and XIII. The major indication for CRYO transfusion is fibrinogen deficiency with increased risk of bleeding when fibrinogen is <100 mg/dL, a transfusion trigger rarely followed by the house staff or other clinicians. To limit wastage, Transfusion Services issue them as pools of five individual CRYO units. The use of CRYO at Robert Wood Johnson University Hospital (RWJUH) has significantly risen since 2010, so we conducted a study to identify the

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Ho, Debbie, Erick Chan, Don Campbell, et al. "Targeted cryoprecipitate transfusion in severe traumatic haemorrhage." Injury 51, no. 9 (2020): 1949–55. http://dx.doi.org/10.1016/j.injury.2020.05.044.

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Green, Laura, Jahnavi Daru, Julie Dodds, et al. "Effect of early cryoprecipitate transfusion versus standard care in women who develop severe postpartum haemorrhage (ACROBAT) in the UK: a protocol for a pilot cluster randomised trial." BMJ Open 10, no. 6 (2020): e036416. http://dx.doi.org/10.1136/bmjopen-2019-036416.

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IntroductionThe incidence of severe postpartum haemorrhage (PPH) that requires blood transfusion is on the increase. Fibrinogen levels have been shown to drop early and significantly during PPH, which is associated with worse outcomes. Early fibrinogen replacement could potentially improve outcomes. No studies have investigated the clinical impact of early cryoprecipitate transfusion in PPH. Prior to performing a full-scale trial, a pilot study is needed to determine feasibility of the intervention and recruitment.MethodsACROBAT is a cluster-randomised pilot study with a qualitative evaluation

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Mcnicol, P. L., G. Liu, I. D. Harley, et al. "Blood Loss and Transfusion Requirements in Liver Transplantation: Experience with the First 75 Cases." Anaesthesia and Intensive Care 22, no. 6 (1994): 666–71. http://dx.doi.org/10.1177/0310057x9402200604.

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The blood loss data and transfusion requirements including blood bank, salvaged washed red cells, fresh frozen plasma and cryoprecipitate were analysed for the first 75 cases of liver transplantation performed at the Austin Hospital between June 1988 and October 1992. The mean blood loss was 8.8 litres (standard deviation 14.1) with a median value of 4.0 litres. Blood product use expressed as mean number of units (SD) was bank red blood cells 7.1 (12.7), washed red blood cells 3.9 (5.9), fresh frozen plasma 7.1 (9.1), platelets 5.1 (7.4), and cryoprecipitate 1.7 (5.1). These results demonstrat

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Refaai, Majed A., Kelly F. Henrichs, Joanna M. Heal, et al. "ABO Identical and Washed Transfusions Are Candidate Strategies to Reduce Early Mortality in Acute Promyelocytic Leukemia (APL)." Blood 128, no. 22 (2016): 4011. http://dx.doi.org/10.1182/blood.v128.22.4011.4011.

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Abstract Background: Despite dramatically improved long term outcomes seen with all-trans retinoic acid therapy in APL, early mortality remains a substantial challenge. Recent data from a single center (Haematologica 2012; 97:133) and the Surveillance, Epidemiology and End Results (SEER) registry (Blood 2011; 118: 1248) report 30 day mortality rates of 26% (n = 18 of 70) and 17% (n = 238 of 1400), respectively. Early deaths are predominately due to hemorrhage. Patients with APL invariably have abnormal laboratory hemostasis tests. The standard of practice is to prophylactically transfuse plate

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Galstyan, G. M., T. V. Gaponova, E. B. Zhiburt, et al. "Clinical guidelines for cryoprecipitate transfusions." Russian journal of hematology and transfusiology 65, no. 1 (2020): 87–114. http://dx.doi.org/10.35754/0234-5730-2020-65-1-87-114.

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Background. Cryoprecipitate is made from fresh-frozen plasma (FFP) and contains ﬁbrinogen, factor VIII, factor XIII, von Willebrand factor, ﬁbronectin and ﬁbrinogen.Aim. To provide information on the composition and methods of production, storage, transportation and clinical use of cryoprecipitate.General ﬁndings. Cyoprecipitate is manufactured by slowly thawing FFP at 1–6°C. This precipitates out cryoproteins: factor VIII, von Willebrand factor, factor XIII, ﬁbronectin and ﬁbrinogen. After centrifugation, the cryoproteins are resuspended in a reduced volume of plasma. Cryoprecipitate is store

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Duan, Lian, E. Wang, Guo-Huang Hu, Cheng-Liang Zhang, Si-Ni Liu, and Yan-Ying Duan. "Preoperative autologous platelet pheresis reduces allogeneic platelet use and improves the postoperative PaO2/FiO2 ratio in complex aortic surgery: a retrospective analysis." Interactive CardioVascular and Thoracic Surgery 31, no. 6 (2020): 820–26. http://dx.doi.org/10.1093/icvts/ivaa200.

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Abstract OBJECTIVES An autologous platelet-rich plasma pheresis (aPP) strategy can harvest partial whole blood that is separated into erythrocytes, plasma and platelets, and can reduce blood loss and transfusion during cardiovascular surgery using cardiopulmonary bypass (CPB). However, the blood and organ conservation effects of this technique have not been confirmed in the context of complex aortic surgery. METHODS Perioperative records of 147 adult patients who underwent complex aortic surgery were analysed retrospectively. RESULTS All patients received regular blood conservation treatment,

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Iwashita, Yoshiaki, Akitaka Yamamoto, Kei Suzuki, et al. "Clinical experience on cryoprecipitate transfusion for trauma patient." Nihon Shuchu Chiryo Igakukai zasshi 22, no. 1 (2015): 23–26. http://dx.doi.org/10.3918/jsicm.22.23.

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Nascimento, B., S. Rizoli, G. Rubenfeld, et al. "Cryoprecipitate transfusion: assessing appropriateness and dosing in trauma." Transfusion Medicine 21, no. 6 (2011): 394–401. http://dx.doi.org/10.1111/j.1365-3148.2011.01098.x.

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Yoo, Dong-Won, Hyun-Ji Lee, Seung-Hwan Oh, et al. "Transfusion Requirements and Blood Bank Support in Heart and Lung Transplantation." Laboratory Medicine 52, no. 1 (2020): 74–79. http://dx.doi.org/10.1093/labmed/lmaa044.

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Abstract Objective Transplantations may require massive transfusion of blood products. Therefore, blood banks need to predict, prepare, and supply the required amount of blood products. Methods We measured the volume of transfused blood components as red blood cells, fresh frozen plasma, platelets, and cryoprecipitate in 54 and 89 patients who received heart and lung transplantation, respectively, in our hospital between January 2012 and December 2019. Results Platelets were the most frequently transfused blood component. Transfusion volumes during heart and lung transplantation surgeries diff

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Scott, John P., Robert A. Niebler, Eckehard A. E. Stuth, et al. "Rotational Thromboelastometry Rapidly Predicts Thrombocytopenia and Hypofibrinogenemia During Neonatal Cardiopulmonary Bypass." World Journal for Pediatric and Congenital Heart Surgery 9, no. 4 (2018): 424–33. http://dx.doi.org/10.1177/2150135118771318.

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Background: Thrombocytopenia and hypofibrinogenemia during neonatal cardiopulmonary bypass (CPB) contribute to bleeding and morbidity. Rotational thromboelastometry (ROTEM) is a viscoelastic assay with a rapid turnaround time. Data validating ROTEM during neonatal cardiac surgery remain limited. This study examined perioperative hemostatic trends in neonates treated with standardized platelet and cryoprecipitate transfusion during CPB. We hypothesized that ROTEM would predict thrombocytopenia, hypofibrinogenemia, and the correction thereof. Methods: Forty-four neonates undergoing CPB were incl

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Blumberg, Neil, Kelly F. Gettings, and Joanna M. Heal. "ABO Mismatched Platelet, Plasma and Cryoprecipitate Transfusions and Bleeding in Transfused Surgical Patients." Blood 106, no. 11 (2005): 4166. http://dx.doi.org/10.1182/blood.v106.11.4166.4166.

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Abstract Three observations led us to investigate whether infusion of ABO non-identical platelets might impair, rather than improve hemostasis. (1) Exposure of platelets to immune complexes or platelet specific antibody can interfere with platelet function in vitro (Thromb Haemost76: 774, 1996). (2) In surgical patients receiving similar numbers of platelet transfusions, those receiving ABO non-identical platelets require 50% more red cell transfusions (Transfusion41: 790, 2001). (3) Patients with acute leukemia receiving prophylactic platelet transfusions typically are reported with serious b

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Chambers, Gregory. "Treatment of Afibrinogenemia in a Chihuahua." Journal of the American Animal Hospital Association 49, no. 1 (2013): 70–74. http://dx.doi.org/10.5326/jaaha-ms-5837.

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This report discusses the diagnosis and treatment of afibrinogenemia in a Chihuahua. Prolongations of prothrombin time (PT), activated partial thromboplastin time (aPTT), and thrombin clotting time (TCT) together with fibrinogen assay results of either no or trace amounts of fibrinogen support a diagnosis of afibrinogenemia. Differential diagnoses include common coagulopathies, liver failure, and disseminated intravascular coagulation (DIC). Either aggressive cryoprecipitate or plasma transfusions are required to treat afibrinogenemia. The current guidelines for treatment of coagulopathies inc

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Buell, Thomas J., Davis G. Taylor, Ching-Jen Chen, et al. "Rotational thromboelastometry–guided transfusion during lumbar pedicle subtraction osteotomy for adult spinal deformity: preliminary findings from a matched cohort study." Neurosurgical Focus 46, no. 4 (2019): E17. http://dx.doi.org/10.3171/2019.1.focus18572.

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OBJECTIVESignificant blood loss and coagulopathy are often encountered during adult spinal deformity (ASD) surgery, and the optimal intraoperative transfusion algorithm is debatable. Rotational thromboelastometry (ROTEM), a functional viscoelastometric method for real-time hemostasis testing, may allow early identification of coagulopathy and improve transfusion practices. The objective of this study was to investigate the effect of ROTEM-guided blood product management on perioperative blood loss and transfusion requirements in ASD patients undergoing correction with pedicle subtraction osteo

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Tsang, H. C., P. Mathias, N. Hoffman, and M. B. Pagano. "Transfusion Medicine Informatics: Analysis of User Burden from Clinical Decision Support Alerts in Promoting Patient Blood Management." American Journal of Clinical Pathology 154, Supplement_1 (2020): S123—S124. http://dx.doi.org/10.1093/ajcp/aqaa161.270.

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Abstract Introduction/Objective To increase efficiency of blood product ordering and delivery processes and improve appropriateness of orders, a major project to implement clinical decision support (CDS) alerts in the electronic medical record (EMR) was undertaken. A design team was assembled including hospital and laboratory medicine information technology and clinical informatics, transfusion services, nursing and clinical services from medical and surgical specialties. Methods Consensus-derived thresholds in hemoglobin/hematocrit, platelet count, INR, and fibrinogen for red blood cell (RBC)

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Chow, Jonathan H., Khang Lee, Ezeldeen Abuelkasem, Obi R. Udekwu, and Kenichi A. Tanaka. "Coagulation Management During Liver Transplantation: Use of Fibrinogen Concentrate, Recombinant Activated Factor VII, Prothrombin Complex Concentrate, and Antifibrinolytics." Seminars in Cardiothoracic and Vascular Anesthesia 22, no. 2 (2017): 164–73. http://dx.doi.org/10.1177/1089253217739689.

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Coagulation management, and transfusion practice in liver transplantation (LT) have been evolving in the recent years due to better understanding of coagulation abnormalities in end-stage liver disease, and clinical management of LT patients. Avoidance of allogeneic blood components is feasible in some patients, but multi-modal coagulation therapies may be necessary in others who develop complex coagulopathy due to hemorrhage, hemodilution, hypothermia, and acid-base disturbances. Transfusions of plasma and cryoprecipitate remain to be the mainstay therapy for procoagulant factor replacement d

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İndelen, Cenk, Yeşim Uygun Kızmaz, Ahmet Kar, Aryeh Shander, and Kaan Kırali. "The cost of one unit blood transfusion components and cost-effectiveness analysis results of transfusion improvement program." Turkish Journal of Thoracic and Cardiovascular Surgery 29, no. 2 (2021): 150–57. http://dx.doi.org/10.5606/tgkdc.dergisi.2021.20886.

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Background: This study aims to analyze the cost of the entire transfusion process in Turkey including evaluation of the cost of transfusion from the perspective of hospital management and determination of savings achieved with the transfusion improvement program. Methods: Invoices, labor, material costs were calculated with micro-costing method, while general production expenses were calculated with gross costing method between January 2018 and December 2019. Unit costs for each blood product were calculated separately by collecting unit acquisition costs, material costs, labor costs, and gene

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Stover, Price E., Lawrence C. Siegel, Reg Parks, et al. "Variability in Transfusion Practice for Coronary Artery Bypass Surgery Persists Despite National Consensus Guidelines." Anesthesiology 88, no. 2 (1998): 327–33. http://dx.doi.org/10.1097/00000542-199802000-00009.

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Background An estimated 20% of allogeneic blood transfusions in the United States are associated with cardiac surgery. National consensus guidelines for allogeneic transfusion associated with coronary artery bypass graft (CABG) surgery have existed since the mid- to late 1980s. The appropriateness and uniformity of institutional transfusion practice was questioned in 1991. An assessment of current transfusion practice patterns was warranted. Methods The Multicenter Study of Perioperative Ischemia database consists of comprehensive information on the course of surgery in 2,417 randomly selected

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Prittie, Jennifer. "The role of cryoprecipitate in human and canine transfusion medicine." Journal of Veterinary Emergency and Critical Care 31, no. 2 (2021): 204–14. http://dx.doi.org/10.1111/vec.13034.

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Innerhofer, P. "Perioperative management of coagulation." Hämostaseologie 26, S 02 (2006): S3—S14. http://dx.doi.org/10.1055/s-0037-1617076.

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SummaryGuidelines of official societies for diagnosis and therapy of intraoperatively occurring hypocoagulability rely mainly on data of patients receiving whole blood transfusions. They recommend -provided that laboratory evaluation shows deficiency (values >1.5 fold normal)- administration of fresh frozen plasma, cryoprecipitate and platelet concentrates (platelet count <50 000 or <100 000/μl). This article describes the pathogenesis of coagulopathy in the light of the special intraoperative setting, emphasizes recent changes of blood component preparation, transfusion triggers, eff

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Innerhofer, P. "Perioperative management of coagulation." Hämostaseologie 26, S 02 (2006): S3—S14. http://dx.doi.org/10.1055/s-0037-1617086.

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SummaryGuidelines of official societies for diagnosis and therapy of intraoperatively occurring hypocoagulability rely mainly on data of patients receiving whole blood transfusions. They recommend -provided that laboratory evaluation shows deficiency (values >1.5 fold normal)- administration of fresh frozen plasma, cryoprecipitate and platelet concentrates (platelet count <50 000 or <100 000/μl).This article describes the pathogenesis of coagulopathy in the light of the special intraoperative setting, emphasizes recent changes of blood component preparation, transfusion triggers, effe

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Politsmakher, Alex, Dipanita Barua, and Harvey Dosik. "Effective Reduction of Blood Product Use In a Community Teaching Hospital: a Possible Interventional Model." Blood 116, no. 21 (2010): 1126. http://dx.doi.org/10.1182/blood.v116.21.1126.1126.

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Abstract Abstract 1126 Background: The complications of blood transfusions and the increased morbidity and mortality associated with liberal use of blood products have been convincingly demonstrated. The clinical problems they pose have prompted development of evidence-based transfusion guidelines. Nevertheless, most hospitals do not enforce these guidelines and effective strategies have not been developed. Continuing medical education, such as conferences, do not appear to be effective in changing physician behavior, as confirmed in the literature and by our hospital's experience. New York Me

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Tan, JunJie, IntanIliana Iliassa, Wan Mohd ZahiruddinWan Mohammad, and Yasmin Ayob. "A retrospective review of cryoprecipitate transfusion practice in Kuala Lumpur Hospital." Asian Journal of Transfusion Science 10, no. 2 (2016): 145. http://dx.doi.org/10.4103/0973-6247.187934.

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Nace, Gary W., and Michael L. Nance. "Early Cryoprecipitate Use—Time to Change Our Pediatric Massive Transfusion Protocol?" JAMA Surgery 156, no. 5 (2021): 460. http://dx.doi.org/10.1001/jamasurg.2020.7266.

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Ritchie, Michael, Cathy Woodward, Lauren Kane, and Melissa Frei-Jones. "Thromboelastrography Reduces Blood Product Transfusion in Pediatric Cardiac Surgery." Blood 120, no. 21 (2012): 1176. http://dx.doi.org/10.1182/blood.v120.21.1176.1176.

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Abstract Abstract 1176 Thromboelastography (TEG) has emerged as an important tool to guide blood product transfusions in pediatric cardiac surgery requiring cardio-pulmonary bypass (CPB). Blood product transfusions are associated with risk including transfusion transmitted infections, transfusion reactions, and allo-immunization. Previous studies have reported fewer red cell and plasma transfusions but increased platelet transfusions with no difference in post-operative bleeding in pediatric CPB using TEG to determine transfusion needs. In this study, we evaluated the use of intra-operative TE

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Handa, Anjali, Sunita Bundas, and Ashok Pal. "Utilization pattern of blood and its components in a tertiary care super speciality hospital." International Journal Of Community Medicine And Public Health 7, no. 11 (2020): 4526. http://dx.doi.org/10.18203/2394-6040.ijcmph20204756.

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Background: Blood is the most precious gift for human life. Blood transfusion services play a vital role in managing health care services. There is no substitute for blood and its components till date, therefore blood donation drive is very crucial. The primary responsibility of blood transfusion services is to provide safe, sufficient and timely supply of blood and blood products. There has been shift for usage of blood and blood components from the use of whole blood so that maximum utilization of this precious resource could be done. Aim and objectives was to study pattern of utilization of

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Pine, Alexander B., Eun-Ju Lee, Mikkael A. Sekeres, et al. "North American Cooperative Group Members' Patterns of Blood Products Transfusion for Patients with Acute Leukemia." Blood 126, no. 23 (2015): 1138. http://dx.doi.org/10.1182/blood.v126.23.1138.1138.

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Abstract Background. Transfusion of blood products is an integral component of the management of patients with acute leukemias. However, high-quality evidence and clinical trial data to support specific practices of blood product transfusion in this population are limited. We hypothesized that there is wide variation in blood product transfusion practices among providers in North America who manage patients with acute leukemia. Methods. A 30-question web-based survey about transfusion practices was emailed to members of the Eastern Cooperative Oncology Group (ECOG)-ACRIN Cancer Research Group,

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Hegerova, Livia, Jeffrey P. Anderson, and Colleen T. Morton. "A Systems-Based Approach to Improve Fibrinogen Testing and Treatment of Low Fibrinogen in Patients Receiving Massive Transfusions: A Quality Improvement Initiative." Blood 128, no. 22 (2016): 2335. http://dx.doi.org/10.1182/blood.v128.22.2335.2335.

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Abstract Background: Uncontrolled hemorrhage is the most common treatable cause of death and four of every ten trauma patients die as a results of exsanguination, or its late effects (Curry et al. Scand J Trauma 2014). There is an increasing understanding of the state of acute coagulopathy and the role that fibrinogen plays in major hemorrhage (Wikkelso A et al. Cochrane Syst Rev 2013). Fibrinogen is a critical protein for hemostasis and clot formation. Low fibrinogen is a risk factor for hemorrhage in patients with major hemorrhage including surgical, obstetrics and trauma patients. Observati

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Yulianto Sarim, Budi. "Manajemen Perioperatif pada Perdarahan akibat Atonia Uteri." Jurnal Anestesi Obstetri Indonesia 3, no. 1 (2020): 47–58. http://dx.doi.org/10.47507/obstetri.v3i1.42.

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Perdarahan obstetri merupakan penyebab utama kematian maternal dan perinatal. Atonia uteri merupakan penyebab tersering perdarahan postpartum. Perdarahan post partum adalah perdarahan lebih dari 500 cc setelah bayi lahir pervaginam atau lebih dari 1.000 ml setelah persalinan abdominal atau jumlah perdarahan lebih dari normal dan telah menyebabkan perubahan tanda vital. Penyebab atonia uteri adalah overdistensi uterus, kelelahan otot miometrium, plasenta letak rendah, toksin bakteri (korioamnionitis, endomiometritis, septikemia), hipoksia akibat hipoperfusi atau uterus couvelaire pada solusio p

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Aung, Fleur M., Jordan Myint, Erin T. Roughneen, and Benjamin Lichtiger. "Transfusion Needs In 28 Cases Of Acute Promyelocytic Leukemia: A Single Institutional Experience." Blood 122, no. 21 (2013): 4827. http://dx.doi.org/10.1182/blood.v122.21.4827.4827.

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Introduction Acute Promyelocytic Leukemia (APL), a distinct subtype of acute myeloid leukemia is a relatively rare disease, characterized by a severe coagulopathy which is often present at the time of diagnosis. Mortality due to bleeding complications during induction is more common in this subtype than in other FAB classifications. The number of newly diagnosed cases in the US is estimated to be 600 to 800 cases a year. The introduction of all-trans retinoic acid (ATRA) into the therapy of APL has completely revolutionized the management and outcome of this disease. The treatment and cure of

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Echeverria, A., K. Mendes, A. Holman, et al. "Cryoprecipitate Wastage: An Unintended Consequence of Introduction of A Massive Transfusion Protocol." Journal of Surgical Research 179, no. 2 (2013): 197. http://dx.doi.org/10.1016/j.jss.2012.10.294.

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Khan, R., V. Venkatesh, A. Curley, S. Stanworth, C. Josephson, and B. Potterjoy. "259 Frozen Plasma and Cryoprecipitate Transfusion Practices among Neonatologists - A National Survey." Archives of Disease in Childhood 97, Suppl 2 (2012): A75. http://dx.doi.org/10.1136/archdischild-2012-302724.0259.

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Ketchum, Lloyd, John R. Hess, and Seppo Hiippala. "Indications for Early Fresh Frozen Plasma, Cryoprecipitate, and Platelet Transfusion in Trauma." Journal of Trauma: Injury, Infection, and Critical Care 60, Supplement (2006): S51—S58. http://dx.doi.org/10.1097/01.ta.0000199432.88847.0c.

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Stanworth, Simon J. "The Evidence-Based Use of FFP and Cryoprecipitate for Abnormalities of Coagulation Tests and Clinical Coagulopathy." Hematology 2007, no. 1 (2007): 179–86. http://dx.doi.org/10.1182/asheducation-2007.1.179.

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Abstract There continues to be a general but unfounded enthusiasm for fresh frozen plasma (FFP) or frozen plasma (FP) usage across a range of clinical specialties in hospital practice. Plasma for transfusion is most often used where there are abnormal coagulation screening tests, either therapeutically in the face of bleeding, or prophylactically in nonbleeding patients prior to invasive procedures or surgery. Little evidence exists to inform best therapeutic transfusion practice, and most studies describe plasma use in a prophylactic setting. Laboratory abnormalities of coagulation are consid

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Teixeira, Pedro G. R., Didem Oncel, Demetrios Demetriades, et al. "Blood Transfusions in Trauma: Six-Year Analysis of the Transfusion Practices at a Level I Trauma Center." American Surgeon 74, no. 10 (2008): 953–57. http://dx.doi.org/10.1177/000313480807401015.

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The objective of this study was to analyze the transfusion practices in trauma patients in one institution. A retrospective analysis of the Trauma Registry linked with the Blood Bank Database of a Level 1 trauma center was conducted. Over 6 years, 17 per cent of the 25,599 trauma patients received blood transfusions. The overall mortality in transfused patients was 20 per cent and remained the same during the study period. There was no change in the proportion of patients receiving transfusions throughout the years, however there was a significant 23.5 per cent reduction in the mean number of

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Boylan, John F., John R. Klinck, Alan N. Sandler, et al. "Tranexamic Acid Reduces Blood Loss, Transfusion Requirements, and Coagulation Factor Use in Primary Orthotopic Liver Transplantation." Anesthesiology 85, no. 5 (1996): 1043–48. http://dx.doi.org/10.1097/00000542-199611000-00012.

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Background Patients with end-stage liver disease frequently incur large-volume blood loss during liver transplantation associated with mechanical factors, preexisting coagulopathy, and intraoperative fibrinolysis. Methods Between April 1992 and May 1994, the authors of this double-blind, randomized, placebo-controlled study examined the effect of high-dose tranexamic acid (maximum of 20 g) on blood loss and blood product requirements in patients undergoing primary isolated orthotopic liver transplantation. Primary outcome measures were volume of blood loss (intraoperative blood loss and postop

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SHIBAHASHI, Keita, Shigeko NISHIMURA, Kazuhiro SUGIYAMA, Hidenori HODA, Yuichi HAMABE, and Hiroshi FUJITA. "Initial Results of Empirical Cryoprecipitate Transfusion in the Treatment of Isolated Severe Traumatic Brain Injury: Use of In-house-produced Cryoprecipitate." Neurologia medico-chirurgica 59, no. 10 (2019): 371–78. http://dx.doi.org/10.2176/nmc.oa.2019-0062.

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Wahidiyat, Pustika Amalia, Elida Marpaung, and Stephen Diah Iskandar. "Characteristics of Acute Transfusion Reactions and its related factors in Cipto Mangunkusumo Hospital Jakarta, Indonesia." Health Science Journal of Indonesia 10, no. 1 (2019): 15–20. http://dx.doi.org/10.22435/hsji.v10i1.1847.

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Latar belakang: Reaksi transfusi akut (RTA) merupakan sekelompok kejadian yang tidak diinginkan akibat pemberian transfusi darah. Manifestasi dari RTA bervariasi dari yang ringan hingga mengancam nyawa. Saat ini, data mengenai reaksi transfusi di Indonesia masih sangat terbatas. Dalam studi ini, kami bertujuan untuk memberikan gambaran mengenai karakteristik RTA dan faktor-faktor yang mempengaruhinya. Metode: Studi ini merupakan studi retrospektif yang melibatkan 288 subyek dengan RTA. Studi dilakukan di Rumah Sakit Dr. Cipto Mangunkusumo, dimulai sejak Januari hingga Desember 2017. RTA

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Adukauskienė, Dalia, Audronė Veikutienė, Agnė Adukauskaitė, Vincentas Veikutis, and Kęstutis Rimaitis. "The usage of blood components in obstetrics." Medicina 46, no. 8 (2010): 561. http://dx.doi.org/10.3390/medicina46080081.

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Major obstetric hemorrhage remains the leading cause of maternal morbidity and mortality worldwide. Even though blood transfusion may be a life-saving procedure, an inappropriate usage of blood products in obstetric emergencies especially in cases of massive bleeding is associated with increased morbidity and risk of death. Thorough knowledge of the etiology, pathophysiology, and optimal therapeutic options of major obstetric hemorrhage may help to avoid lethal outcomes. There are evidence-based data about some risks related with transfusion of blood components: acute or delayed hemolytic, feb

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Norda, Rut, Elsa Tynell, and Olof ??kerblom. "Cumulative Risks of Early Fresh Frozen Plasma, Cryoprecipitate and Platelet Transfusion in Europe." Journal of Trauma: Injury, Infection, and Critical Care 60, Supplement (2006): S41—S45. http://dx.doi.org/10.1097/01.ta.0000199546.22925.31.

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Callum, Jeannie, Michael E. Farkouh, Damon C. Scales, et al. "Effect of Fibrinogen Concentrate vs Cryoprecipitate on Blood Component Transfusion After Cardiac Surgery." JAMA 322, no. 20 (2019): 1966. http://dx.doi.org/10.1001/jama.2019.17312.

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Gaitanidis, Apostolos, Robert T. Sinyard, Charlie J. Nederpelt, et al. "Lower Mortality with Cryoprecipitate During Massive Transfusion in Penetrating but Not Blunt Trauma." Journal of Surgical Research 269 (January 2022): 94–102. http://dx.doi.org/10.1016/j.jss.2021.07.027.

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