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Journal articles on the topic 'Cryotherapy'
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Carolina, Dina, Nyimas Heny Purwanti, and Titi Sulastri. "PENGARUH CRYOTHERAPY DAN ORALCARE STANDAR YANG DIGUNAKAN RS TERHADAP DERAJAT ORAL MUCOSITISPADA ANAK LEUKEMIA." Jurnal Ilmiah Kesehatan 9, no. 2 (July 10, 2020): 66–71. http://dx.doi.org/10.52657/jik.v9i2.1221.
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Leukemia merupakan urutan kanker nomer satu yang banyak ditemui pada anak. Penatalaksanaan untuk memberantas sel kanker leukemia salah satunya adalah dengan kemoterapi. Kemoterapi merupakan pemberian segolongan obat-obatan yang bersifat sitotoksik, yang efek sampingnya dapat menyebabkan oral mucositis. Pemberian cryotherapy dirasakan perlu untuk menurunkan dan mencegah derajat oral mucositis pada anak. Cryotherapy adalah pemberian es keping sebelum, sesaat dan setelah dilakukan kemoterapi selama kurang lebih 70 menit. Penelitian ini dilakukan untuk melihat pengaruh cryotherapy dan oral care standar terhadap derajat oral mucositis. Penelitian ini menggunakan Quasi experimen dengan rancangan non equivalent control group before after design. Tehnik sampling yang digunakan adalah purposive sampling dengan 74 responden. Uji yang dilakukan adalah uji t paired dan independent t tes. Hasil menunjukan adanya pengaruh pemberian cryotherapi dan oral care standar RS terhadap kelompok intervensi dan kontrol dengan (p=0,000). Cryotherapy dapat dijadikan sebagai salah satu intervensi atraumatic care anak selama menjalani kemoterapi.
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Karakuzu, Ali, and I. Ezgi Urgancı Tatlı. "Cryotherapy." TURKDERM 52, no. 2 (June 25, 2018): 76–77. http://dx.doi.org/10.4274/turkderm.93274.
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Laudi, M., and G. Fontana. "Cryotherapy." Urologia Journal 71, no. 1 (January 2004): 52–55. http://dx.doi.org/10.1177/039156030407100112.
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Musani, Ali I., and Akrum Al-Zubaidi. "Cryotherapy." Journal of Bronchology & Interventional Pulmonology 22, no. 2 (April 2015): 97–98. http://dx.doi.org/10.1097/lbr.0000000000000162.
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Kerr, Kate. "Cryotherapy." Physiotherapy 84, no. 6 (June 1998): 293–94. http://dx.doi.org/10.1016/s0031-9406(05)65542-3.
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Shinohara, Katsuto. "Cryotherapy." International Journal of Clinical Oncology 12, no. 6 (December 2007): 416–26. http://dx.doi.org/10.1007/s10147-007-0708-4.
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Sobel, Daniel B., and Alistair G. S. Philip. "Prolonged Dexamethasone Therapy Reduces the Incidence of Cryotherapy for Retinopathy of Prematurity in Infants of Less Than 1 Kilogram Birth Weight With Bronchopulmonary Dysplasia." Pediatrics 90, no. 4 (October 1, 1992): 529–33. http://dx.doi.org/10.1542/peds.90.4.529.
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To determine whether prolonged dexamethasone therapy, used in the treatment of bronchopulmonary dysplasia (BPD), affects the incidence of cryotheraphy for retinopathy of prematurity, the authors conducted a retrospective review of all infants admitted to a neonatal intensive care unit between October 1988 and October 1990 (n = 957) whose birth weights were less than 1 kg (n = 90). All admissions were reviewed to determine birth weight, gestational age, survival, incidence of BPD and cryotherapy, use and duration of dexamethasone therapy, length of mechanical ventilation, continuous positive airway pressure, and additional supplemental oxygen. Of all neonatal intensive care unit admissions, 9.4% weighed less than 1 kg, and 64% survived for greater than 28 days (n = 58). Of the survivors, 82% had BPD. Cryotherapy for retinopathy of prematurity was used only in those with birth weights of less than 1 kg and with BPD. All those treated with dexamethasone (n = 23) had BPD and significantly lower gestational ages (25.6 vs 26.4 weeks) (P= .05) and birth weights (759 vs 824 g) (P < .05) than those not treated (n = 25). Dexamethasone was used in 23 of 48 infants (9 for ≤24 days, 14 for >24 days). Eleven required cryotherapy: 5 of 25 with no dexamethasone, 5 of 9 treated for 24 days or less, and 1 of 14 treated for longer than 24 days (P < .04). In those treated with prolonged (>24 days) dexamethasone, cryotherapy was significantly reduced compared with those treated for shorter periods. Although the probability was significant, the 95% confidence intervals were wide. Controlled prospective trials are needed to determine optimal usage and side effects of dexamethasone in premature infants.
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Luethy, Daniela. "Cryotherapy Techniques." Veterinary Clinics of North America: Equine Practice 37, no. 3 (December 2021): 685–93. http://dx.doi.org/10.1016/j.cveq.2021.07.005.
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Maiwand, M., and Praveen Mathur. "Endobronchial Cryotherapy." Seminars in Respiratory and Critical Care Medicine 18, no. 06 (November 1997): 545–54. http://dx.doi.org/10.1055/s-2007-1009370.
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Homasson, Jean-Paul. "Bronchoscopic Cryotherapy." Journal of Bronchology 2, no. 2 (April 1995): 145–53. http://dx.doi.org/10.1097/00128594-199504000-00013.
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Hatch, Kenneth D. "6 Cryotherapy." Baillière's Clinical Obstetrics and Gynaecology 9, no. 1 (March 1995): 133–43. http://dx.doi.org/10.1016/s0950-3552(05)80362-1.
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Gupta, Somesh, Savita Yadav, Suman Patra, and Sanjeev Gupta. "Fractionated cryotherapy." Journal of the American Academy of Dermatology 77, no. 3 (September 2017): e69-e71. http://dx.doi.org/10.1016/j.jaad.2017.03.033.
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Gage, Andrew A. "Selective Cryotherapy." Cell Preservation Technology 2, no. 1 (March 2004): 3–14. http://dx.doi.org/10.1089/153834404322708709.
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Neifeld, James P. "Hepatic cryotherapy." Seminars in Surgical Oncology 14, no. 2 (March 1998): 97–98. http://dx.doi.org/10.1002/(sici)1098-2388(199803)14:2<97::aid-ssu1>3.0.co;2-1.
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Iwakiri, Kentaro, Akio Kobayashi, Yuichi Takeuchi, Yusuke Kimura, Yoichi Ohta, and Hiroaki Nakamura. "Efficacy of continuous local cryotherapy following total hip arthroplasty." SICOT-J 5 (2019): 13. http://dx.doi.org/10.1051/sicotj/2019010.
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Background: Cryotherapy is rarely reported on the usefulness of cryotherapy applied after total hip arthroplasty (THA), and there are no reports about patient satisfaction against the cryotherapy following THA. The aim of this study was whether cryotherapy can be useful for relieving pain, reducing blood loss, and swelling, and improving patient satisfaction after THA. Methods: Thirty patients who had undergone THA were treated by a controlled cooling device for 72 h following THA (defined as the cryotherapy group). The other 30 patients without cryotherapy were not treated with cryotherapy (defined as the control group). Blood samples (creatine kinase, and C-reactive protein), estimated blood loss, visual analog scale (VAS) of pain score, total doses of diclofenac sodium suppository used for pain relief, thigh swelling, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, and adverse outcomes were compared between two groups. Results: Thigh circumference, measured on only day 4 postoperatively, was significantly lower in the cryotherapy than in the control group. Furthermore, patient satisfaction on postoperative days 4 and 7 was significantly higher in the cryotherapy than in the control group. There were no significant differences in other outcomes between groups. Conclusions: These results support the potential benefit of cryotherapy for the reduction of swelling, and patient satisfaction during postoperative recovery of patients undergoing THA, even in the presence of periarticular injection and tranexamic acid administration for the prevention of postoperative pain and bleeding. Postoperative cryotherapy is a potentially simple, noninvasive, and relatively inexpensive option for post-THA management.
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Ali, Mahboob, Muhammad Adeel Siddiqui, and Majid Hussain. "Comparative Study Between Treatment with Cryotherapy Alone Versus Cryotherapy Plus Salicylic Acid Dressing for Planter Warts." Pakistan Journal of Medical and Health Sciences 16, no. 12 (December 31, 2022): 724–27. http://dx.doi.org/10.53350/pjmhs20221612724.
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Objective: To compare cryotherapy alone versus cryotherapy plus salicylic acid dressing for planter warts. Study Design: Randomized Control Trial Place and Duration of Study: Department of Dermatology, Combined Military Hospital, Abbottabad from 01 Mar, 2022 to 01 Aug, 2022. Methodology: Seventy participants were enlisted using a non-probability sequential sampling method and then randomly assigned to one of two groups. SPSS Version 23.0 was used for data entry, data entry, and data analysis. Results: As per comparison of efficacy between both groups, 20 (57.1%) patients in Group A (Cryotherapy Alone) showed effective results while in Group B (Cryotherapy plus Salicylic Acid), 30 (85.7%) patients showed effective results. P Value = 0.008. Conclusion: This study demonstrated that treatment of plantar warts with cryotherapy plus salicylic acid yielded significantly higher effective results in comparison to cryotherapy alone. Keywords: Planter Warts, Cryotherapy, Salicylic Acid
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Huffman, Deanna, Austin Primeaux, Elizabeth Reilly Helm, Lily Zhiying Chen, Joseph Mason, Rafael Guzman-Arevalo, Andrew G. Chapple, and Michelle Marie Loch. "A single-center retrospective review of the impact of cryotherapy on peripheral neuropathy scores in patients with breast cancer who received chemotherapy with a taxane-based treatment regimen." Journal of Clinical Oncology 42, no. 16_suppl (June 1, 2024): e24106-e24106. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e24106.
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e24106 Background: Taxanes are a class of chemotherapy frequently used for neoadjuvant and adjuvant treatment of breast cancer. While effective, taxane use is not without adverse effects, the most well-known being chemotherapy-induced peripheral neuropathy (CIPN). As CIPN is dose-related, it can lead to dose reductions and interruptions in therapy that may be detrimental to the patient. Cryotherapy has been used as a prevention strategy, but its efficacy remains unclear. Methods: We performed a retrospective review of the cryotherapy program in our center. Included patients had breast cancer of any stage treated with a taxane in the neoadjuvant or adjuvant setting. All patients were offered cryotherapy at the time of their treatment and were separated into cohorts whether they opted in or out (“cryotherapy” and “non cryotherapy,” respectively). Neuropathy scores were collected by nursing staff via survey and scaled from 0-4. Patient demographics and neuropathy scoring were compared between the “cryotherapy” and “non cryotherapy” cohorts. Results: In total, 41 patients were included. Nearly half of patients in each cohort experienced neuropathy, 10 patients (41.7%) treated with cryotherapy and 8 patients (47.1%) without cryotherapy use. Younger age (46.5 years vs 57 years, p = 0.060), and patients using Medicaid (35.3% vs 75.0%, when compared to all other insurance types, p = 0.023) predicted cryotherapy use. Use of paclitaxel also predicted cryotherapy used when compared to docetaxel (76.0% and 31.2%, respectively, p = 0.009). There was not a significant difference in predicted neuropathy score between the cohorts (Adjusted Multiplicative Effect = .81, 95% CI = .34-1.96, p = .645). Conclusions: Our data did not suggest that the use of cryotherapy could predict lower neuropathy scores, but our study suffered from small sample size and short-duration of follow-up. Additional large, randomized trials with standard neuropathy scoring scales are needed to better evaluate the efficacy of cryotherapy in prevention of CIPN for breast cancer patients receiving taxane-based therapy.
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Ptaszek, Bartłomiej, Szymon Podsiadło, Justyna Adamiak, Jakub Marchewka, Łukasz Tota, and Aneta Teległów. "Effect of Whole-Body Cryotherapy on Oxidant–Antioxidant Imbalance in Women with Multiple Sclerosis." Journal of Clinical Medicine 12, no. 18 (September 13, 2023): 5958. http://dx.doi.org/10.3390/jcm12185958.
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The aim of the study was to investigate whether 20 whole-body cryotherapy treatments have an effect on oxidative–antioxidant imbalances in women with multiple sclerosis. Fifty women aged 30–55 were examined: study group—15 women with multiple sclerosis, subjected to whole-body cryotherapy; first control group—20 women with multiple sclerosis who did not receive cryotherapy intervention; second control group—15 healthy women who participated in cryotherapy treatments. Blood from the examined women was collected twice (before and after the series of 20 cryotherapy sessions). An insignificant increase in the total antioxidant capacity (study group: p = 0.706; second control group: p = 0.602) was observed after the whole-body cryotherapy intervention. After the series of cryotherapy sessions, the total oxidative status/total oxidative capacity value was insignificantly decreased among the multiple sclerosis patients (decrease by 14.03%, p = 0.495). In women with multiple sclerosis, no significant cryotherapy impact was demonstrated on changes in the oxidant–antioxidant imbalance or concentrations of nitric oxide, uric acid, or matrix metalloproteinase-9.
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Nithyanandham Masilamani and Dhanraj Ganapathy. "Awareness of cryotherapy in sports medical applications among dental students." International Journal of Research in Pharmaceutical Sciences 11, SPL3 (October 7, 2020): 1095–98. http://dx.doi.org/10.26452/ijrps.v11ispl3.3341.
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Cryotherapy is the use of cold for either the management of injury or illness, has become common across sports medicine. It remains a well-established procedure for managing serious soft tissue damages. However, there is the disparity between both the theoretical evidence for cryotherapy in clinical trials. This survey was performed for assessing the awareness about cryotherapy in sports medical applications amongst dental students. A cross-sectional study was done with a self-administered questionnaire with 10 questions circulated among 100 dental students. The questionnaire assessed the awareness about cryotherapy in sports medical applications, their medicinal uses, anti-inflammatory activity, mechanism of action and side effects. The responses were recorded and analysed. 87% of the respondents were not aware of medical uses of Cryotherapy.73% were not aware of the anti-inflammatory activity of Cryotherapy.83 % were not aware of the mechanism of action of Cryotherapy. 85% were not aware of the side effects of Cryotherapy. The awareness about the use of cryotherapy in sports medical applications is very less among dental students. Increased awareness programs and sensitization and continuing dental education programs along with greater importance to the curricular modifications in sports dentistry should be incorporated to improve the awareness levels.
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Castro, Paula A. T. S., Germanna M. Barbosa, Dafiner H. Machanocker, Raphael S. Peres, Thiago M. Cunha, Jonathan E. Cunha, Francisco F. B. Oliveira, et al. "Clinical-like cryotherapy in acute knee arthritis of the knee improves inflammation signs, pain, joint swelling, and motor performance in mice." PLOS ONE 17, no. 1 (January 21, 2022): e0261667. http://dx.doi.org/10.1371/journal.pone.0261667.
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To assess the effects of clinical-like cryotherapy on inflammatory signs (in vivo neutrophil migration, cytokines, and joint inflammation), pain, joint swelling, balance, and motor coordination in mice with knee arthritis. Young C57BL/6 mice were randomly divided into three groups (8 to 10 mice per group): Control group: mice with no intervention; antigen-induced arthritis (AIA) group: mice sensitized and immunized with intra-articular (i.a.) injection of methylated bovine serum albumin (mBSA); and AIA + cryotherapy group: mice sensitized, immunized with i.a. injection of mBSA, and submitted to a clinical-like cryotherapy protocol. After 21 days of sensitization, AIA and AIA + cryotherapy groups received i.a. injection of mBSA (100 μg/joint) to induce joint inflammation, and a clinical-like cryotherapy protocol was applied to AIA + cryotherapy group (crushed ice bag, two cryotherapy sessions of 20 min every two hours). Experimental analysis was conducted in the initial (immediately after i.a. injection of mBSA) and final periods (two hours after the second cryotherapy session). The number of synovial fluid neutrophils, cytokine levels, joint histology, pain, joint swelling, and motor performance were also analyzed. Our results showed that clinical-like cryotherapy in mice with acute knee arthritis reduced inflammatory signs, pain, and joint swelling, and improved balance and motor coordination.
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Handley, J. M., R. D. Maw, T. Horner, H. Lawther, T. McNeill, and W. W. Dinsmore. "Non-specific immunity in patients with primary anogenital warts treated with interferon alpha plus cryotherapy or cryotherapy alone." Acta Dermato-Venereologica 72, no. 1 (January 1, 1992): 39–40. http://dx.doi.org/10.2340/00015555723940.
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Combination treatment of primary anogenital warts with subcutaneous interferon alpha 2a plus cryotherapy was no more efficacious than cryotherapy alone. Patients with primary AG warts showed no in vitro or in vivo suppression of non-specific immunity. In patients treated with interferon plus cryotherapy non-specific cellular immunity was stimulated, both in vitro and in vivo compared with patients treated with cryotherapy alone.
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Kodetova, Martina, Radka Hobzova, Jakub Sirc, Jiri Uhlik, Katerina Dunovska, Karel Svojgr, Ana-Irina Cocarta, et al. "The Role of Cryotherapy in Vitreous Concentrations of Topotecan Delivered by Episcleral Hydrogel Implant." Pharmaceutics 14, no. 5 (April 20, 2022): 903. http://dx.doi.org/10.3390/pharmaceutics14050903.
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Transscleral diffusion delivery of chemotherapy is a promising way to reach the vitreal seeds of retinoblastoma, the most common intraocular malignancy in childhood. In this in vivo study, the delivery of topotecan via lens-shaped, bi-layered hydrogel implants was combined with transconjunctival cryotherapy to assess whether cryotherapy leads to higher concentrations of topotecan in the vitreous. The study included 18 New Zealand albino rabbits; nine rabbits received a topotecan-loaded implant episclerally and another nine rabbits received transconjunctival cryotherapy superotemporally 2 weeks before implant administration. Median vitreous total topotecan exposures (area under the curve, AUC) were 455 ng·h/mL for the cryotherapy group and 281 ng·h/mL for the non-cryotherapy group, and were significantly higher in the cryotherapy group, similar to maximum levels. Median plasma AUC were 50 ng·h/mL and 34 ng·h/mL for the cryotherapy and non-cryotherapy groups, respectively, with no statistically significant differences between them. In both groups, AUC values in the vitreous were significantly higher than in plasma, with plasma exposure at only approximately 11–12% of the level of vitreous exposure. The results confirmed the important role of the choroidal vessels in the pharmacokinetics of topotecan during transscleral administration and showed a positive effect of cryotherapy on intravitreal penetration, resulting in a significantly higher total exposure in the vitreous.
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Chen, Joey, Jamie Seabrook, Adrienne Fulford, and Irina Rajakumar. "Icing oral mucositis: Oral cryotherapy in multiple myeloma patients undergoing autologous hematopoietic stem cell transplant." Journal of Oncology Pharmacy Practice 23, no. 2 (July 9, 2016): 116–20. http://dx.doi.org/10.1177/1078155215620920.
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Background Up to 70% of patients receiving hematopoietic stem cell transplant develop oral mucositis as a side effect of high-dose melphalan conditioning chemotherapy. Oral cryotherapy has been documented to be potentially effective in reducing oral mucositis. The aim of this study was to examine the effectiveness of the cryotherapy protocol implemented within the hematopoietic stem cell transplant program. Methods A retrospective chart review was conducted of adult multiple myeloma patients who received high-dose melphalan conditioning therapy for autologous hematopoietic stem cell transplant. Primary endpoints were incidence and severity of oral mucositis. Secondary endpoints included duration of oral mucositis, duration of hospital stay, parenteral narcotics use and total parenteral nutrition use. Results One hundred and forty patients were included in the study, 70 patients in both no cryotherapy and cryotherapy groups. Both oral mucositis incidence and severity were found to be significantly lower in the cryotherapy group. Fifty (71.4%) experienced mucositis post cryotherapy compared to 67 (95.7%) in the no cryotherapy group (p < 0.001). The median oral mucositis severity, assessed using the WHO oral toxicity scale from grade 0–4, experienced in the no group was 2.5 vs. 2 in the cryotherapy group (p = 0.03). Oral mucositis duration and use of parenteral narcotics were also significantly reduced. Duration of hospital stay and use of parenteral nutrition were similar between the two groups. Conclusion The cryotherapy protocol resulted in a significantly lower incidence and severity of oral mucositis. These results provide evidence for the continued use of oral cryotherapy, an inexpensive and generally well-tolerated practice.
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Morgan, Jessica, Darko Stefanovski, Margret Lenfest, Sraboni Chatterjee, and James Orsini. "Novel dry cryotherapy system for cooling the equine digit." Veterinary Record Open 5, no. 1 (January 2018): e000244. http://dx.doi.org/10.1136/vetreco-2017-000244.
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ObjectivesDigital cryotherapy is commonly used for laminitis prophylaxis and treatment. Currently validated methods for distal limb cryotherapy involve wet application or compression technology. There is a need for a practical, affordable, dry cryotherapy method that effectively cools the digit. The objective of this study was to evaluate the hoof wall surface temperatures (HWSTs) achieved with a novel dry cryotherapy technology.DesignRepeated-measures in vivo experimental study.SettingExperimental intervention at a single site.Participants6 systemically healthy horses (3 mares, 3 geldings).InterventionsCryotherapy was applied to six horses for eight hours with a commercially available rubber and rubber and welded fabricice boot, which extended proximally to include the foot and pastern. Reusable malleable cold therapy packs were secured against the foot and pastern with the three built-in hook-and-loop fastener panels.Primary and secondary outcome measuresHWST and pastern surface temperature of the cryotherapy-treated limb, HWST of the control limb and ambient temperature were recorded every five minutes throughout the study period.ResultsResults were analysed with mixed-effects multivariable regression analysis. The HWST (median 11.1°C, interquartile range 8.6°C–14.7°C) in the cryotherapy-treated limb was significantly decreased compared with the control limb (median 29.7°C, interquartile range 28.9°C–30.4°C) (P≤0.001). Cryotherapy limb HWST reached a minimum of 6.75°C (median) with an interquartile range of 4.1°C–9.3°C. Minimum HWST was achieved 68 minutes after cryotherapy pack application.ConclusionsDry application of cryotherapy significantly reduced HWST and reached minimums below the therapeutic target of 10°C. This cryotherapy method might offer an effective alternative for digital cooling.
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Patrick, Helen, Niroshan Jayasekara, Colin Fitzpatrick, Fionnuala Finnerty, I. Wijerathna, Rebecca Murdock, and Daniel Richardson. "P248 Genital warts and treatment options: clinical audit." Sexually Transmitted Infections 93, Suppl 1 (June 2017): A97.2—A97. http://dx.doi.org/10.1136/sextrans-2017-053232.290.
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IntroductionGenital warts are a common presenting condition in sexual health clinics. There are different treatment options available within BASHH guidelines depending on the size and location of warts. Home treatment reduces follow up clinic attendance.MethodWe randomly selected 30 patients attending our integrated sexual health service with new genital warts and audited their management against local guidance that home treatment with Imiquimod should be used first line for 4 weeks, unless contraindicated.ResultsOf the 30 patients, 18 were male and 12 were female. 14/30 were prescribed Imiquimod only. 7 patients had Cryotherapy only and 9 were also given cryotherapy before Imiquimod. 9/11 who received cryotherapy requested this treatment. 6/11 had documented reasons why it was deemed appropriate to have cryotherapy (unable to apply cream themselves, site of lesion). Interestingly, all 9/9(100%) who had received combination treatment reported clinical resolution within 4 weeks. 6/7(86%) who had cryotherapy only clinically resolved after 3 consecutive applications. 11/14(79%) treated with Imiquimod only resolved within 4 weeks, one deferred. 11/19(58%) treated with Imiquimod experienced side effects and five patients (5/11) sought medical advice. There were no reported complications following cryotherapy application.DiscussionDespite imiquimod being the recommended first line initial treatment for genital warts in our service, some patients received cryotherapy treatment in isolation or a combination of imiquimod and cryotherapy. The patients receiving cryotherapy were likely to have requested this treatment and had less side effects. All patients who received imiquimod and cryotherapy had resolution of genital warts in four weeks.
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Terai, Sozaburo, Christian Zantop, and Thore Zantop. "The effect of combined cryotherapy/compression versus cryotherapy following ACL recon in return-to-sports after 3 months." Orthopaedic Journal of Sports Medicine 8, no. 9_suppl7 (September 1, 2020): 2325967120S0054. http://dx.doi.org/10.1177/2325967120s00548.
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Introduction: Morbidity following ACL reconstruction may be a key factor contributing to muscular dysfunction and influencing physical activity. While intra-operative details have been the focus of standardization within the last years, strategies reducing the morbidity such as postoperative cryotherapy have been investigated less. Goal of this study was to compare subjective and objective patient outcomes following ACL reconstruction with combined compression and cryotherapy compared with traditional cryotherapy alone. Hypotheses: We hypothesized that cryotherapy/compression will show significantly better results three months after ACL reconstruction compared to cryotherapy alone. Methods: A total of 40 Patients undergoing ACL reconstruction are prospectively randomized to be treated with cryotherapy/compression device (GameReady, CA/USA, group 1) or a cryotherapy device (Aircast Cryocuff, DJO CA/USA, group 2). ACL reconstructions were performed by a single surgeon with semitendinosus graft and standardized rehabilitation protocol. Patients were instructed to use the ice therapy devices 4 times per day for 30min. Pain management directly postoperatively was analyzed as recorded during clinical records and VAS. Follow-up was performed at 12 weeks postoperatively using visual analog scale (VAS), Lysholm knee score, Short Form 36 (SF36), and Tegner acitiy score. Additionally, a functional “return-to-sports” analysis including isokinetic strength measurements (BTE-primus), proprioceptive tests (MTF tests) and a 3d-motion analysis (myomotion, Noraxon) during bilateral drop jumps and single leg hop tests was performed. Results: VAS and comparison of the administrated painkillers showed no significant differences between the two groups. Both groups used the cryotherapy/compression device and the cryotherapy device as determined by the study protocol. At 12 weeks, there was no significant difference between the two groups with regard to Lysholm score, Tegner score, and SF-36, however there was a trend towards better scores in group 1. The was a higher range of motion in group 1 compared to group 2. Functional analysis with isokinetic strength measurements, proprioceptive test and a 3d-motion analysis revealed better functional results in patients of the group cryotherapy/compression device compared to cryotherapy alone. Conclusion: This prospective analysis of 40 patients following semitendinosus ACL reconstruction with one single surgeon implicates that the use of a cryotherapy/compression device (GameReady) showed significantly better objective patient outcomes following ACL reconstruction compared to cryotherapy alone.
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Hawkins, Jeremy R., and Shawn W. Hawkins. "Clinical Applications of Therapeutic Modalities Among Collegiate Athletic Trainers, Part I: Cryotherapy." International Journal of Athletic Therapy and Training 21, no. 1 (January 2016): 62–67. http://dx.doi.org/10.1123/ijatt.2015-0035.
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Cryotherapy is commonly used by athletic trainers, although evidence is inconsistent to support its usage. Data are also lacking as to how athletic trainers treat common injuries with cryotherapy. The purpose of this study was to ascertain how collegiate athletic trainers approach the use of cryotherapy and whether that usage reflects what little we know about the modalities. Survey results indicated great variability in respondents’ approaches to the treatment of an acute and subacute ankle sprain. Additional data are needed to create clear treatment guidelines with respect to cryotherapy. Certain aspects of the application of cryotherapy should be reviewed and use adjusted accordingly.
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Kashiwagi, Eiji, Takashi Hatano, Kanichiro Shimiz, Atsushi Takamoto, Koji Tomita, Takahiro Osawa, Yusuke Sakuhara, et al. "Evaluation of the safety and effectiveness of cryoablation in the treatment of renal angiomyolipoma related to tuberous sclerosis complex: The Cryo-TSC." Journal of Clinical Oncology 41, no. 6_suppl (February 20, 2023): 669. http://dx.doi.org/10.1200/jco.2023.41.6_suppl.669.
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669 Background: Tuberous sclerosis complex (TSC) is an autosomal dominant inherited disease. Approximately 60%–80% of patients with TSC have bilateral angiomyolipoma (AML). Cryotherapy is one treatment option for renal tumors, but the safety and efficacy of cryotherapy for TSC–AML is not clear. We planned this study to establish the safety and efficacy of cryotherapy for TSC–AML. Methods: This was an open-label, single-arm phase II study to evaluate the safety and efficacy of cryotherapy for TSC–AML of 4 cm or less in diameter in patients at least 16 years old. The exclusion criteria were an inability to withdraw from mTOR inhibitor and failure to maintain rest during cryotherapy. mTOR inhibitors were withdrawn at least 7 days prior to cryotherapy and discontinued during the study period. Cryotherapy was performed using Cryohit (Galil Medical LTD, USA). Safety was assessed at 1, 2, 6, and 9 months after cryotherapy, and efficacy was assessed at 3 and 9 months after cryotherapy. The efficacy of cryotherapy was evaluated according to the modified RECIST or RECIST criteria. The primary endpoint was the disease control rate, and secondary endpoints included the overall response rate, safety, renal function, quality of life, and need for additional treatment. Results: The disease control and overall response rates were 100% and 93.3%, respectively. After 9 months of follow-up, the median creatine level was slightly increased by 0.06 mg/dL. Quality of life was stable, and no additional treatment was needed. Three Grade 3 adverse events (hematuria, chronic kidney disease, and aspartate aminotransferase elevation) were observed in three patients. Conclusions: Cryoablation is a safe and effective treatment option for TSC–AML. Clinical trial information: jRCTs072200039 .
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Huang, Christina M., Emily Y. Lu, and Mark G. Kirchhof. "Cellulitis Secondary to Liquid Nitrogen Cryotherapy: Case Report and Literature Review." Journal of Cutaneous Medicine and Surgery 21, no. 4 (March 30, 2017): 334–38. http://dx.doi.org/10.1177/1203475417702152.
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Background: Liquid nitrogen cryotherapy is a commonly used technique to treat a wide variety of dermatologic conditions including actinic keratoses, non-melanoma skin cancers, verrucae, and seborrheic keratoses. The risks associated with liquid nitrogen cryotherapy are important to know and discuss with patients prior to treatment. Objective: We report a case of cellulitis secondary to liquid nitrogen cryotherapy for actinic keratosis. We sought to review the literature for an estimate of secondary infection rates following cryotherapy treatment. Methods: We searched Pubmed using the terms cryotherapy and infection or cellulitis. We then looked at articles classified as clinical trials where cryotherapy was used to treat skin conditions. We then selected clinical trials that listed cellulitis or infection as an adverse event. Results and Conclusion: There were no case reports, case series, or review articles detailing the risk of infection from liquid nitrogen cryotherapy. We found 8 articles classified as clinical trials on Pubmed that did list infection as an adverse event. The risk of infection from these studies varied from approximately 2% to 30%. There was a great degree of heterogeneity in treatment sites, length of treatment, and treatment targets. While it is difficult to determine the true incidence of infection from liquid nitrogen cryotherapy, clinicians should endeavor to inform patients of this potential risk.
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Huo, Wei, Ya-Li Gao, Hong-Yi Wang, Gui-Jiao Bi, Shuai Qiao, Yun-Fei Cai, Rui-Qun Qi, et al. "Local Hyperthermia Versus Cryotherapy for Treatment of Plantar Warts: A Prospective Multi-centre Non-randomized Concurrent Controlled Clinical Trial." Acta Dermato-Venereologica 102 (February 28, 2022): adv00655. http://dx.doi.org/10.2340/actadv.v102.1082.
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Cryotherapy is one of the most common treatments for warts; however, pain during treatment and relatively high recurrence rates limit its use. Local hyperthermia has also been used successfully in the treatment of plantar warts. The aim of this study was to compare the clinical effectiveness of local hyperthermia vs cryotherapy for the treatment of plantar warts. This multi- centre, open, 2-arm, non-randomized concurrent controlled trial included 1,027 patients, who received either cryotherapy or local hyperthermia treatment. Three months after treatment, local hyperthermia and cryotherapy achieved complete clearance rates of 50.9% and 54.3%, respectively. Recurrence rates were 0.8% and 12%, respectively. Pain scores during local hyperthermia were significantly lower than for cryotherapy. Both local hyperthermia and cryotherapy demonstrated similar efficacy for clearance of plantar warts; while local hyperthermia had a lower recurrence rate and lower pain sensation during treatment.
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Malinti, Evelin, and Febri A. Nabuasa. "Cryotherapy Dan Intensitas Nyeri Pada Injeksi Intrakutan." Klabat Journal of Nursing 1, no. 1 (May 8, 2019): 22. http://dx.doi.org/10.37771/kjn.v1i1.380.
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CRYOTHERAPY DAN INTENSITAS NYERI PADA INJEKSI INTRAKUTAN
Abstrak
Cryotherapy merupakan aplikasi terapi suhu rendah atau dingin yang digunakan untuk berbagai keperluan seperti mengurangi pembengkakan pada trauma, peradangan dan mengurangi nyeri. Cryotherapy juga telah digunakan untuk menangani nyeri pada prosedur penyuntikan seperti penyuntikan subkutan dan intravena. Secara khusus penelitian ini bertujuan untuk mengevaluasi perbedaan efek dari cryotherapy kering dan basah pada intensitas nyeri injeksi intrakutan. Metode: yang digunakan dalam penelitian ini adalah quasi ekperimen dengan post-test design. Pemilihan sample menggunakan teknik purposive sampling untuk memperoleh total 54 responden yang dibagi kedalam dua kelompok. Penelitian ini membandingkan intensitas nyeri kedua kelompok menggunakan numerical pain rating scale. Masing-masing kelompok mendapatkan aplikasi cryotherapy pada area penyuntikan selama 5 menit sebelum dilakukan injeksi intrakutan. Kelompok I diberikan aplikasi cryotherapy dalam bentuk es batu dalam plastik es yang dibungkus kantong kain. Kelompok II diberikan aplikasi washlap yang telah dicelupkan dalam air es. Hasil penelitian menunjukkan bahwa rata-rata intensitas nyeri pada kelompok I berada pada kategori nyeri sedang, dan kelompok II berada pada kategori nyeri berat terkontrol. Uji t-independen menunjukkan bahwa terdapat perbedaan signifikan pada intensitas nyeri diantara kedua kelompok (p<0.05). Dengan demikian aplikasi cryotherapy dengan es batu selama 5 menit lebih efektif mengurangi intensitas nyeri pada injeksi intrakutan. Aplikasi cryotherapy dapat dilakukan untuk mengurangi nyeri pada injeksi intrakutan.
CRYOTHERAPY AND PAIN INTENSITY ON INTRACUTANEOUS INJECTION
Abstract
Cryotherapy is an application of low or cold temperature therapy that is used for various purposes such as reducing swelling in trauma, inflammation and reducing pain. Cryotherapy has also been used to treat pain in injection procedures such as subcutaneous and intravenous injections. In particular, this study aimed to evaluate the differences in the effects of dry and wet cryotherapy on the pain intensity of intracutaneous injection. The method used in this study is quasi experiment with post-test design. The sample selection uses a purposive sampling technique to obtain a total of 54 respondents divided into two groups. This study compared the intensity of pain between the two groups using the numerical pain rating scale. Each group received an application of cryotherapy in the injection area for 5 minutes before intracutaneous injection. Group I was given the application of cryotherapy in the form of ice cubes in ice plastic wrapped in a cloth bag. Group II was given the washlap application which had been dipped in ice water. The results showed that the average pain intensity in group I was in the moderate pain category, and group II was in the category of heavily controlled pain. Independent t-test showed that there were significant differences in pain intensity between the two groups (p <0.05). Thus the application of cryotherapy with ice cube for 5 minutes is more effective in reducing pain intensity in intracutaneous injection. The application of cryotherapy can be done to reduce pain in intracutaneous injection.
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Barry, S., and B. Toft. "Cryotherapy induced analgesia: an investigation mapping cryotherapy induced analgesia." Physiotherapy 101 (May 2015): e123-e124. http://dx.doi.org/10.1016/j.physio.2015.03.264.
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Upadana, Gede Ngurah, I. Nyoman Mangku Karmaya, and Anak Agung Sagung Sawitri. "Association between husband support and compliance with post-cryotherapy requirements among mothers in Tabanan District, Bali." Public Health and Preventive Medicine Archive 7, no. 2 (December 1, 2019): 148. http://dx.doi.org/10.15562/phpma.v7i2.226.
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Background and purpose: Cervical cancer is a major global health problem for women, with most of cases occurring in developing countries. Visual inspection with acetic acid (VIA) is one method for screening precancerous cervical lesions which can then be followed up with cryotherapy. The success of cryotherapy is influenced by many factors including maternal compliance to meet the clinical requirements after cryotherapy. This study aims to determine the association between husband's support and mother's compliance with post-cryotherapy requirements. Methods: A cross-sectional study was conducted on 142 mothers with positive VIA test results and had received cryotherapy in six Tabanan public health centers (PHCs) consisting of four PHCs in urban areas and two PHCs in rural areas. All mothers who underwent cryotherapy during 2017 were selected as samples. Data were collected through face-to-face interviews in each respondent's home using a questionnaire. The information collected was four post-cryotherapy requirements consisting of sexual abstinence, on schedule follow-up examinations, finishing the entire antibiotic regimen, not using topical vaginal medication and husband's support. Husband's support was measured by 11 questions including social, psychological and environmental supports. Bivariate and multivariate analysis were performed with chi-square test and logistic regression respectively. Results: This study shows that only 39.4% of respondents were compliant to meet the four post cryotherapy requirements. As many as 32.4% of mothers had sex within 4 weeks after cryotherapy and 40.1% did not have the follow up examinations on schedule. Husband's support was significantly associated with maternal compliance in the form of asking about respondent’s health condition with AOR=6.658 (95%CI: 1.794-24.702) and not asking for coitus with AOR=4.151 (95%CI: 1.491-11.556). Conclusion: Mother's compliance in carrying out the four requirements after cryotherapy remains low and the husband's support has a role in increasing maternal compliance. Education about post cryotherapy requirements needs to be improved including involving the role of the husband.
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Upadana, Gede Ngurah, Anak Agung Sagung Sawitri, and I. Nyoman Mangku Karmaya. "Association between husband support and compliance with post-cryotherapy requirements among mothers in Tabanan District, Bali." Public Health and Preventive Medicine Archive 7, no. 2 (December 1, 2019): 148–55. http://dx.doi.org/10.53638/phpma.2019.v7.i2.p12.
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Background and purpose: Cervical cancer is a major global health problem for women, with most of cases occurring in developing countries. Visual inspection with acetic acid (VIA) is one method for screening precancerous cervical lesions which can then be followed up with cryotherapy. The success of cryotherapy is influenced by many factors including maternal compliance to meet the clinical requirements after cryotherapy. This study aims to determine the association between husband’s support and mother’s compliance with post-cryotherapy requirements. Methods: A cross-sectional study was conducted on 142 mothers with positive VIA test results and had received cryotherapy in six Tabanan public health centers (PHCs) consisting of four PHCs in urban areas and two PHCs in rural areas. All mothers who underwent cryotherapy during 2017 were selected as samples. Data were collected through face-to-face interviews in each respondent’s home using a questionnaire. The information collected was four post-cryotherapy requirements consisting of sexual abstinence, on schedule follow-up examinations, compliance to the recommended antibiotic use, not using topical vaginal medication and husband’s support. Husband’s support measured by 11 questions consisted of psychological, social and environmental support. Bivariate analysis was performed with chi-square and multivariate analysis with logistic regression. Results: This study shows that only 39.4% of respondents were compliant to meet the four post cryotherapy requirements. As many as 32.4% of mothers had sex within 4 weeks after cryotherapy and 40.1% did not have the follow up examinations on schedule. Husband’s support was significantly associated with maternal compliance in the form of asking about respondent’s health condition with AOR=6.658 (95%CI: 1.794-24.702) and not asking for sex with AOR=4.151 (95%CI: 1.491-11.556). Conclusion: Mother’s compliance with the four requirements after cryotherapy remains low and the husband’s support has a role in increasing maternal compliance. Education on post cryotherapy requirements needs to be improved particularly in regards to the role of the husband.
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Costello, Joseph T., and Alan E. Donnelly. "Cryotherapy and Joint Position Sense in Healthy Participants: A Systematic Review." Journal of Athletic Training 45, no. 3 (May 1, 2010): 306–16. http://dx.doi.org/10.4085/1062-6050-45.3.306.
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Abstract Objective: To (1) search the English-language literature for original research addressing the effect of cryotherapy on joint position sense (JPS) and (2) make recommendations regarding how soon healthy athletes can safely return to participation after cryotherapy. Data Sources: We performed an exhaustive search for original research using the AMED, CINAHL, MEDLINE, and SportDiscus databases from 1973 to 2009 to gather information on cryotherapy and JPS. Key words used were cryotherapy and proprioception, cryotherapy and joint position sense, cryotherapy, and proprioception. Study Selection: The inclusion criteria were (1) the literature was written in English, (2) participants were human, (3) an outcome measure included JPS, (4) participants were healthy, and (5) participants were tested immediately after a cryotherapy application to a joint. Data Extraction: The means and SDs of the JPS outcome measures were extracted and used to estimate the effect size (Cohen d) and associated 95% confidence intervals for comparisons of JPS before and after a cryotherapy treatment. The numbers, ages, and sexes of participants in all 7 selected studies were also extracted. Data Synthesis: The JPS was assessed in 3 joints: ankle (n = 2), knee (n = 3), and shoulder (n = 2). The average effect size for the 7 included studies was modest, with effect sizes ranging from −0.08 to 1.17, with a positive number representing an increase in JPS error. The average methodologic score of the included studies was 5.4/10 (range, 5–6) on the Physiotherapy Evidence Database scale. Conclusions: Limited and equivocal evidence is available to address the effect of cryotherapy on proprioception in the form of JPS. Until further evidence is provided, clinicians should be cautious when returning individuals to tasks requiring components of proprioceptive input immediately after a cryotherapy treatment.
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Kazantsev, Dmitriy I., Aleksandr A. Ochkurenko, Vladimir A. Peleganchuk, and Yurii M. Batrak. "The evaluation of the effectiveness of cryotherapy after a knee replacement in the early postoperative period. Systematic review." N.N. Priorov Journal of Traumatology and Orthopedics 31, no. 1 (April 25, 2024): 109–26. http://dx.doi.org/10.17816/vto611023.
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A literature review of the clinical efficacy of various methods of local cryotherapy after knee endoprosthesis in the early postoperative period is presented. A literature search using the keywords “cryotherapy” and “knee arthroplasty” was conducted in the databases Medline.Ru, CyberLeninka, E-Library, PubMed, and Cochrane. The search date was January 7, 2023. The review included studies that assessed the effectiveness of cryotherapy after knee replacement in the early postoperative period. After electronic search, 562 abstracts were found, and 16 studies were included in the review. Although the patients had similar characteristics, significant heterogeneity was noted in the studies according to cryotherapy modality, duration, and frequency of cold exposure. This may have been the reason for the contradictory results of the review. It is challenging to draw a clear conclusion on the advantages and disadvantages of using cryotherapy after knee replacement. Thus, high-quality studies should examine the effectiveness of cryotherapy.
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Spiceland, Clayton M., B. Joseph Elmunzer, Samuel Paros, Logan Roof, Molly McVey, Robert Hawes, Brenda J. Hoffman, and Puja S. Elias. "Salvage cryotherapy in patients undergoing endoscopic eradication therapy for complicated Barrett’s esophagus." Endoscopy International Open 07, no. 07 (July 2019): E904—E911. http://dx.doi.org/10.1055/a-0902-4587.
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Abstract Background and study aims Some patients with dysplastic Barrett’s esophagus (BE) experience suboptimal response to radiofrequency ablation (RFA), endoscopic mucosal resection (EMR), or the combination. Cryotherapy has been used as salvage therapy in these patients, but outcomes data are limited. We aimed to assess clinical outcomes among a large cohort of patients with dysplastic BE whose condition had failed to respond to RFA and/or EMR. Patients and methods This was a retrospective cohort study of consecutive cases of dysplastic BE or intramucosal carcinoma (IMC) treated with salvage cryotherapy at a tertiary-care academic medical center. The primary goal of cryotherapy treatment was eradication of all neoplasia. The secondary goal was eradication of all intestinal metaplasia. The proportion of patients undergoing salvage cryotherapy who achieved complete eradication of dysplasia (CE-D) and metaplasia (CE-IM), as well as the time to CE-D and CE-IM were calculated. Results Over a 12-year period, 46 patients received salvage cryotherapy. All patients underwent RFA prior to cryotherapy, either at our center or prior to referral, and 50 % of patients underwent EMR. A majority of patients (54 %) had high-grade dysplasia (HGD) at referral, while 33 % had low-grade dysplasia (LGD), and 13 % had IMC. Overall, 38 patients (83 %) reached CE-D and 21 (46 %) reached CE-IM. Median time to CE-D was 18 months, median number of total interventions (RFA, cryotherapy, and EMR) was five, and median number of cryotherapy sessions was two. Conclusion Salvage cryotherapy appears safe and effective for treating BE that is refractory to RFA and/or EMR.
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Lyman, Katie J., Michael McCrone, Thomas A. Hanson, Christopher D. Mellinger, and Kara Gange. "Kinesio® Tape Barrier Does Not Inhibit Intramuscular Cooling During Cryotherapy." Journal of Sport Rehabilitation 28, no. 7 (September 1, 2019): 671–76. http://dx.doi.org/10.1123/jsr.2018-0009.
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Context: Allied health care professionals commonly apply cryotherapy as treatment for acute musculoskeletal trauma and the associated symptoms. Understanding the impact of a tape barrier on intramuscular temperature can assist in determining treatment duration for effective cryotherapy. Objective: To determine whether Kinesio® Tape acts as a barrier that affects intramuscular temperature during cryotherapy application. Design: A repeated-measures, counterbalanced design in which the independent variable was tape application and the dependent variable was muscle temperature as measured by thermocouples placed 1 cm beneath the adipose layer. Additional covariates for robustness were body mass index and adipose thickness. Setting: University research laboratory. Participants: Nineteen male college students with no contraindications to cryotherapy, no known sensitivity to Kinesio® Tape, and no reported quadriceps injury within the past 6 months. Intervention: Topical cryotherapy: cubed ice bags of 1 kg and 0.5 kg. Main Outcome Measures: Intramuscular temperature. Results: The tape barrier had no statistically significant effect on muscle temperature. The pattern of temperature change was indistinguishable between participants with and without tape application. Conclusions: Findings suggest that health care professionals can combine cryotherapy with a Kinesio® Tape application without any need for adjustments to cryotherapy duration.
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Pradhan, Binita, and Anagha Pradhan Malla. "Effectiveness of cryotherapy in VIA positive women." Journal of General Practice and Emergency Medicine of Nepal 8, no. 11 (August 16, 2021): 10–13. http://dx.doi.org/10.59284/jgpeman61.
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Introduction: In this study we studied the effectiveness of Cryotherapy in cases with abnormal squamous intraepithelial lesions detected only by VIA.
Method: In our study, 64 patients in reproductive age group attending gynecology OPD, with complaints of discharge per vaginum, lower abdominal pain, and post coital bleeding were screened with VIA and positive women had cryotherapy and they were followed up by same after six months.
Result: A total of 64 VIA positive women had cryotherapy. Most of the women were of age group 31-40 years (40.6%). Majority of the women were of parity 2 or more (89.1%). The most common complaint was discharge (46.9%) followed by pelvic pain (32.8%). VIA was negative among most of the women (87.5%) after cryotherapy. The outcome of cryotherapy was not associated with age and parity rather presence of symptoms was statistically associated (p=0.034).
Conclusion: We concluded that in low resource settings, simple and safe diagnostic test VIA and therapeutic procedure cryotherapy are safe and effective method to combat the killer disease of cervical cancer.
Keywords: Cryotherapy, Visual inspection with acetic acid (VIA), cervix
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NAKADA, STEPHEN Y., FRED T. LEE, THOMAS F. WARNER, SUSAN G. CHOSY, and TIMOTHY D. MOON. "Laparoscopic Renal Cryotherapy in Swine: Comparison of Puncture Cryotherapy Preceded by Arterial Embolization and Contact Cryotherapy." Journal of Endourology 12, no. 6 (December 1998): 567–73. http://dx.doi.org/10.1089/end.1998.12.567.
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Tabassum, Nishat, and Sanghamitra Jena. "Effect of Cryotherapy & Active Stretching Together and Active Stretching Alone for Improving Hamstring Flexibility in Asymptomatic Individuals." International Journal of Health Sciences and Research 11, no. 6 (June 22, 2021): 342–48. http://dx.doi.org/10.52403/ijhsr.20210651.
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Study Objective: To know about the effects of cryotherapy and active stretching together and active stretching alone for improving hamstring flexibility in asymptomatic individuals. Method: 22 subjects were participated in study of the age 18 to 40. Subjects were randomly and equally assigned to static stretching and cryotherapy (group 1) and only active stretching (group 2). Subjects in each group were given stretching and cryotherapy for three weeks. Pre and post assessment of ROM was measured by the KEA, SLR and Sit and reach test. Results: After three weeks of intervention there was a significant difference between pre intervention and post intervention score in both the group but in group 1 showed significant difference between KEA, SLR and SRT variables. Conclusion: Subject who received active stretching and cryotherapy showed better improvement than the control group who received only active stretching. Hence it can be concluded that active stretching along with cryotherapy can improve hamstring flexibility than the active stretching only. Key words: Cryotherapy, flexibility, ROM, active stretching.
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Zhao, Hongli, Shanshan Sun, Zhaodong Wang, Yayun Hong, Lulu Shi, and Minbo Lan. "pH-Sensitive DOX-Loaded PAA-PF127-PAA Micelles Combined with Cryotherapy for Treating Walker 256 Carcinosarcoma in a Rat Model." Journal of Nanoscience and Nanotechnology 18, no. 12 (December 1, 2018): 8070–77. http://dx.doi.org/10.1166/jnn.2018.16409.
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In this work, a novel combination of drug therapy and cryotherapy for tumor treatment was developed. Pluronic F127 modified with poly(acrylic acid) at two terminals (denoted as PAA-PF127-PAA) was used as carriers for doxorubicin (DOX) delivery. Due to the pH-sensitive property endowed by PAA, the DOX-loaded PAA-PF127-PAA micelles released DOX faster in the slightly acidic physiological environment of the tumor site than that in the neutral physiological environment. Three-group rats bearing Walker 256 carcinosarcoma were respectively treated with cryotherapy, combination of DOX-loaded micelles and cryotherapy, and saline injection to investigate the effect of the combined therapy. The apoptosis rate of TdT-mediated dUTP nick-end labeling (TUNEL) slices indicated that compared with cryotherapy alone, the DOX-loaded PAA-PF127-PAA micelles combining with cryotherapy showed increased apoptosis. Thus, the combination of drug therapy and cryotherapy can be used as an effective technique for tumor treatment.
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Lin, Can, Miaomiao Liu, Jihua Guo, and Rong Jia. "Cryotherapy Attenuates Inflammation via the lncRNA SNHG1/miR-9-5p/NFKB1 Regulatory Axis in Periodontal Ligament Cells." International Journal of Molecular Sciences 24, no. 15 (July 28, 2023): 12097. http://dx.doi.org/10.3390/ijms241512097.
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Cryotherapy is a common non-pharmacological method to relieve pain and inflammation. Clinical studies have shown that cryotherapy can reduce postoperative pain after root canal therapy, but the mechanism remains unclear. In this study, we aimed to investigate the underlying molecular mechanisms by which cryotherapy reduces inflammation in lipopolysaccharide (LPS)-stimulated periodontal ligament cells through transcriptome sequencing analysis. We found that cryotherapy significantly reduced the expression of multiple proinflammatory cytokines and chemokines, and NFKB1 was the key regulator down-regulated by cryotherapy. Importantly, we discovered that lncRNA SNHG1 expression level significantly decreased after cold treatment. SNHG1 expression was positively related to NFKB1 while negatively correlated with miR-9-5p, which formed a novel ceRNA regulatory pathway. Knockdown of SNHG1 significantly reduced the expression of NFKB1, IL1B, and IL6, while overexpression of SNHG1 significantly increased the expression of these genes. In conclusion, our study demonstrated that cryotherapy can effectively reduce inflammation in LPS-induced periodontal ligament cells by suppressing the lncRNA SNHG1/miR-9-5p/NFKB1 axis.
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Castro, Paula A. T. S., Dafiner H. Machanocker, Genoveva F. Luna, Germanna M. Barbosa, Jonathan E. Cunha, Thiago M. Cunha, Fernando Q. Cunha, Thiago L. Russo, and Tania F. Salvini. "Clinical-Like Cryotherapy in Acute Knee Arthritis Protects Neuromuscular Junctions of Quadriceps and Reduces Joint Inflammation in Mice." BioMed Research International 2022 (January 22, 2022): 1–9. http://dx.doi.org/10.1155/2022/7442289.
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Rheumatoid arthritis is an autoimmune and inflammatory disease that affects synovial joint tissues and skeletal muscle. Clinical-like cryotherapy benefits signs of joint inflammation in knee osteoarthritis after 60 days of anterior cruciate ligament transection surgery. However, it is unknown whether it also benefits acute knee arthritis (e.g., reduces inflammatory process and protects neuromuscular junction [NMJ] and muscle fibers). We aimed to analyze the effects of clinical-like cryotherapy on NMJ and quadriceps muscle fibers in a model of acute knee arthritis. Twenty-four male C57BL/6 mice (20 to 25 g) were randomly allocated into three groups: control (mice with no intervention), antigen-induced arthritis (AIA; mice sensitized and immunized with intra-articular [i.a.] injection of methylated bovine serum albumin [mBSA]), and AIA+cryotherapy (mice sensitized, immunized with i.a. injection of mBSA, and submitted to a clinical-like cryotherapy protocol). Twenty-one days after sensitization, arthritis was induced in immunized mice via i.a. injection of mBSA (100 μg/joint). Two clinical-like cryotherapy sessions (crushed ice pack for 20 min) were applied two hours apart. The first session was applied immediately after i.a. injection of mBSA. The quadriceps was removed two hours after the second clinical-like cryotherapy session for morphological analysis of muscle fibers (cross-sectional area), frequency distribution of muscle fiber area (%), and NMJ (area, perimeter, and maximum diameter). Gene expressions of mRNA involved in NMJ signaling (γ-nAChR, α1-nAChR, ε-nAChR, Agrin-MusK-Rapsyn, α-dystrobrevin, and utrophin) and atrophy (muscle RING-finger protein-1 and Atrogin-1) pathways were analyzed. Inflammatory signs were assessed in knee joint (swelling, articular surface temperature, and neutrophil migration in synovial fluid). Regarding morphological analysis of muscle fibers, 180 to 270 and >270 μm2 classes were higher in the AIA+cryotherapy than the AIA group. Area, perimeter, and maximum diameter of NMJ also increased in the AIA+cryotherapy compared with the control group. Agrin mRNA expression increased in the AIA+cryotherapy compared with the control and AIA groups. In the atrophy pathway, Atrogin-1 increased compared with the control and AIA groups. The AIA+cryotherapy group reduced knee swelling and neutrophil migration compared with the AIA group. In conclusion, clinical-like cryotherapy increased Agrin expression, contributing to NMJ maintenance and increased Atrogin-1 expression, thus protecting NMJ and muscle fiber. Furthermore, clinical-like cryotherapy reduced inflammatory signs (swelling and neutrophil migration) of acute knee arthritis.
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Domingues, Márcio Luís Pinto. "Cryotherapy and its Correlates to Functional Performance. A Brief Preview." Sport Science Review 22, no. 3-4 (August 1, 2013): 229–54. http://dx.doi.org/10.2478/ssr-2013-0012.
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AbstractObjective:To search the English language literature for original research addressing the effect of cryotherapy on motor performance and recovery.Data Sources:We searched MEDLINE, the Physiotherapy Evidence Database, SPORT Discus, Pubmed, and the Cochrane Reviews database, from 1976 to 2009 to identify randomized clinical trials of cryotherapy, systematic reviews, original articles and methods of cryotherapy. Key words used were cryotherapy, return to participation, cold treatment, ice, injury.Data Synthesis:Brief review including assessment of cryotherapy as a tool of performance and a recovery method.Conclusions:Most studies suggest that a short rewarming time would be beneficial (a couple minutes), which is very reasonable in sports. Also, cooling techniques differ in its result accordingly to the procedures and objectives used. Finally, the type of tissue cooled plays a large role (ie. Joint vs. Muscle).
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Rho, Nark-Kyoung. "Revisiting the Role of Local Cryotherapy for Acne Treatment: A Review and Update." Journal of Clinical Medicine 12, no. 1 (December 20, 2022): 26. http://dx.doi.org/10.3390/jcm12010026.
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Acne vulgaris is a well-recognized condition among adolescents and adults that adversely affects their quality of life. Local cryotherapy has long been reported to be effective in treating acne vulgaris, inducing a more rapid involution of acne than topical medications. However, the use of cryotherapy has been limited for acne treatment due to several drawbacks, including procedural pain and pigmentary alterations. Currently, newer cryotherapy devices are gaining attention in dermatology due to their ability to monitor and precisely control the target temperature. In this narrative review, a brief history and the latest update on acne cryotherapy will be presented. Additionally, a special emphasis is placed on the role of cryotherapy, alone or in combination with intralesional steroid injections for nodulocystic acne.
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Uriasz, Justyna, and Łukasz Kikowski. "APPLICATION OF SYSTEMIC CRYOTHERAPY IN COSMETOLOGY." Acta Balneologica 65, no. 3 (2023): 177–82. http://dx.doi.org/10.36740/abal202303108.
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Aim: The aim of this study was to assess the use of whole-body cryotherapy in cosmetology. Materials and Methods: Literature review was conducted based on the available PubMed bibliographic database from 2012 to 2022. Articles in Polish, English and Russian were included. Keywords such as whole-body cryotherapy, cryogenic chamber, and cryotherapy in cosmetology were used during the publication search. Conclusions: Whole-body cryotherapy is safe for the skin and has minimal effect on changes in pH, moisture and oiliness. Cryotherapy in a cryo-chamber can be used as complimentary therapy for the treatment of skin dermatoses and can also be a non-invasive method of treating various types of hair loss. It can also be an alternative method of reducing body fat.
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Vargens, Octavio M. C., Sonia Nunes, Lolita D. da Silva, and Jane M. Progianti. "Pain Relief Effect of Cryotherapy in Parturients." International Journal of Childbirth 6, no. 3 (2016): 149–56. http://dx.doi.org/10.1891/2156-5287.6.3.149.
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INTRODUCTION: Pain in childbirth and strategies for relieving it have been a subject of interest to researchers for many years. The use of cold (cryotherapy), as a pain relief technique generally, is quite well known and studied. However, few studies have addressed the use of cryotherapy as a strategy for relieving the pain of childbirth.OBJECTIVE: To evaluate the effects of cryotherapy in relieving childbirth pain.METHOD: Pilot intervention study using prospective data in a single intervention group, the outcome being the pain relief in women in labor. The sample comprised 36 parturients at the Hospital Maternidade Carmela Dutra, Rio de Janeiro, Brazil. Cryotherapy was applied to the parturients’ thoracolumbar region at cervical dilation of 5, 7, and/or 9 cm, using an icepack belt. In all, 48 applications were made. The responses regarding the action of cryotherapy on pain were recorded on a specific form. The Numeric Rating Scale (NRS) was used. Following a form, the parturients’ behavior during the application of cryotherapy was also observed.RESULTS: It was found that 91.67% (outcome) of the women reported pain relief and better conditions in which to experience childbirth. The behavior of 75% of the women in labor was calm and participatory; some slept (5.56%), others took short naps (19.44%).CONCLUSION: Cryotherapy proved effective in relieving pain in childbirth. Because characteristically, cryotherapy does not interfere in the physiological process of childbirth, it can be used in care for women in labor.
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Chaudhary, Dipika, Yan Sun, and Xinghua Gao. "Comparison of Cryotherapy and Topical Salicylic Acid in Common Warts: A Systematic Review and Meta-Analysis." Dermatologic Therapy 2023 (November 27, 2023): 1–8. http://dx.doi.org/10.1155/2023/4283918.
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Background. Common warts are most common complaint among children and adults caused by human papillomavirus (HPV). Cryotherapy and topical salicylic acid are common therapies. Objective. To compare the efficacy and safety of cryotherapy and topical salicylic acid in common warts. Methods. Randomized controlled trials (RCTs) comparing cryotherapy and topical salicylic acid treatment in patients with common warts were searched by using PubMed, Embase, Google Scholar, and Cochrane Database of Systematic Reviews up to Oct 20, 2021. The keywords were “common warts/verruca,” “cryotherapy,” and “salicylic acid.” The language was restrained to English. No age or gender limitation was conducted. The outcomes were complete remission of all warts at different observation times, recurrence rates, and side effects. Study-specific effect sizes were pooled by using the fixed-effects model and the Mantel–Haenszel method. I2 was used to assess heterogeneity of studies. Results. Seven articles involving 976 patients randomized into the cryotherapy group or salicylic acid group were included. Of whom, 487 patients received cryotherapy, while 489 received salicylic acid treatment. With the fixed-effects model, the pool effect of complete clearance of warts at 12 weeks comparing cryotherapy and salicylic acid was not statistically significant (RR = 0.99 (0.84–1.17), I2 = 0%). Conclusion. Comparable efficacy of cryotherapy and topical salicylic acid was conducted in common wart treatment. More high-quality pieces of evidence with more samples are needed to confirm the results for further recommendations.
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Furmanek, Mariusz Paweł, Kajetan Słomka, and Grzegorz Juras. "The Effects of Cryotherapy on Proprioception System." BioMed Research International 2014 (2014): 1–14. http://dx.doi.org/10.1155/2014/696397.
Full textAbstract:
Proprioception plays an important role in the complex mechanism of joint control. Contemporary sport activities impose extremely high physical demands on athletes. Winter sports are played in areas with excessively low temperatures. Moreover, many athletes are subjected to treatments that involve local lowering of the body temperature before, during, and after physical activity. This work reviews the current knowledge regarding the influence of local cryotherapy on the proprioception system. The reviewed literature identified several tests that evaluate different aspects of proprioception. There is no universally agreed protocol, or clear set of criteria for test conditions. The outcomes of different tests and assessments of cryotherapy procedures using different cold modalities are poorly correlated. In general, the published results on the mechanism of cryotherapy effects on proprioception are not uniquely conclusive and are frequently contradictory. Additional high-quality research is required to explicitly answer the following questions: (1) whether local cryotherapy influences all aspects of proprioception; (2) whether the current methods of evaluation are adequate for the exploration of the relationship between cryotherapy and proprioception; and (3) whether the application of local cryotherapy is safe for athletes regarding proprioception. The review clearly showed that there is no comprehensive model relating cryotherapy and proprioception.