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Journal articles on the topic 'CSL with CBL'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Shanigarapu, Chaithanya, and M.Srujana. "Designing and Comparative Analyses of Carry Select Adders (CSL, CSL with BEC, CSL with CBL)." International Journal of Multidisciplinary Education Research 4, no. 7(2) (2015): 101–5. https://doi.org/10.5281/zenodo.33099.

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In electronics, adder is a digital circuit that performs addition of numbers. To perform fast arithmetic operations, carry select adder (CSA) is one of the fastest adders used in many data - processing processors. The structure of CSA is such that there is further scope of reducing the area, delay and power consumption. Simple and efficient gate – level modification is used in order to reduce the area, delay and power of CSA. The result analysis shows that the proposed structure(csa CBL) is better than the conventional CSA and CSA with BEC.

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2

Okah, Felix A., R. Randall Wickett, William L. Pickens, and Steven B. Hoath. "Surface Electrical Capacitance as a Noninvasive Beside Measure of Epidermal Barrier Maturation in the Newborn Infant." Pediatrics 96, no. 4 (1995): 688–92. http://dx.doi.org/10.1542/peds.96.4.688.

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Objective. The classical studies of epidermal barrier function in infants have relied on measurement of transepidermal water loss by evaporimetry. This technique, although valuable, is, in practice, slow, expensive, and susceptible to error because of convective air currents. In this prospective study, we evaluated gestation-dependent and postnatal age-dependent changes in epidermal barrier function by measurement of skin surface electrical capacitance (SEC) in 40 newborn infants ranging from 25 to 40 weeks' gestational age. SEC was measured in picofarads with a dermal phase meter. Methodology

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3

Putri, Atica Ramadhani, and Rasmi Zakiah Oktarlina. "Gambaran Preferensi Mahasiswa Tahap Preklinik Fakultas Kedokteran Universitas Lampung Terhadap Berbagai Metode Pengajaran." Unram Medical Journal 11, no. 4 (2022): 1145–52. http://dx.doi.org/10.29303/jk.v11i4.4758.

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Latar belakang: Literatur terbaru telah membandingkan kegunaan metode pengajaran yang spesifik dengan metode lecture. Mahasiswa milenial cenderung lebih memilih pembelajaran yang berorientasi pada tim, serta menyarankan preferensi pendekatan pembelajaran kolaboratif dan berbasis teknologi, namun menurut beberapa literatur, mahasiswa kedokteran lebih menyukai metode lecture yang merupakan metode pengajaran yang pasif.Tujuan: mengetahui gambaran preferensi mahasiswa tahap preklinik Fakultas Kedokteran Universitas Lampung terhadap berbagai metode pengajaran.Metode: Penelitian ini merupakan peneli

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Ramadhani Putri, Atica. "Gambaran Preferensi Mahasiswa Tahap Preklinik Fakultas Kedokteran Universitas Lampung Terhadap Berbagai Metode Pengajaran." Unram Medical Journal 11, no. 4 (2022): 1145–52. http://dx.doi.org/10.29303/jku.v11i4.849.

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Latar Belakang: Literatur terbaru telah membandingkan kegunaan metode pengajaran yang spesifik dengan metode lecture. Mahasiswa milenial cenderung lebih memilih pembelajaran yang berorientasi pada tim, serta menyarankan preferensi pendekatan pembelajaran kolaboratif dan berbasis teknologi, namun menurut beberapa literatur, mahasiswa kedokteran lebih menyukai metode lecture yang merupakan metode pengajaran yang pasif. Tujuan: mengetahui gambaran preferensi mahasiswa tahap preklinik Fakultas Kedokteran Universitas Lampung terhadap berbagai metode pengajaran. Metode: Penelitian ini merupakan pene

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5

Pitakbut, Thanet, and Oliver Kayser. "Anti-Infective Screening of Selected Nine Cannabinoids Against Clostridium perfringens and Influenza A (H5N1) Neuraminidases, and SARS-CoV-2 Main Protease and Spike Protein Interactions." Current Issues in Molecular Biology 47, no. 3 (2025): 185. https://doi.org/10.3390/cimb47030185.

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Recently, cannabinoids have gained scientific interest as a promising anti-infective natural product class, as reported in several studies. However, the existing knowledge is mainly limited to common cannabinoids like THC and CBD. Therefore, this study aims to fill the knowledge gap by investigating the anti-infective potential of nine selected cannabinoids (both common and rare cannabinoids): THC, CBD, CBC, CBE, CBF, CBG, CBL, CBN, and CBT against Clostridium perfringens and Influenza A (H5N1) neuraminidases and SARS-CoV-2 main protease and spike protein–human ACE2 interaction using a standar

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6

Albuquerque, E. F. M., and M. M. Silva. "A comparison by simulation and by measurement of the substrate noise generated by CMOS, CSL, and CBL digital circuits." IEEE Transactions on Circuits and Systems I: Regular Papers 52, no. 4 (2005): 734–41. http://dx.doi.org/10.1109/tcsi.2005.844110.

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7

Poltera, Yann, Giovanni Martucci, Martine Collaud Coen, et al. "PathfinderTURB: an automatic boundary layer algorithm. Development, validation and application to study the impact on in situ measurements at the Jungfraujoch." Atmospheric Chemistry and Physics 17, no. 16 (2017): 10051–70. http://dx.doi.org/10.5194/acp-17-10051-2017.

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Abstract. We present the development of the PathfinderTURB algorithm for the analysis of ceilometer backscatter data and the real-time detection of the vertical structure of the planetary boundary layer. Two aerosol layer heights are retrieved by PathfinderTURB: the convective boundary layer (CBL) and the continuous aerosol layer (CAL). PathfinderTURB combines the strengths of gradient- and variance-based methods and addresses the layer attribution problem by adopting a geodesic approach. The algorithm has been applied to 1 year of data measured by two ceilometers of type CHM15k, one operated

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Gul, Waseem, Shahbaz W. Gul, Mohamed M. Radwan, et al. "Determination of 11 Cannabinoids in Biomass and Extracts of Different Varieties of Cannabis Using High-Performance Liquid Chromatography." Journal of AOAC INTERNATIONAL 98, no. 6 (2015): 1523–28. http://dx.doi.org/10.5740/jaoacint.15-095.

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Abstract An HPLC single-laboratory validation was performed for the detection and quantification of the 11 major cannabinoids in most cannabis varieties, namely, cannabidiolic acid (CBDA), cannabigerolic acid (CBGA), cannabigerol (CBG), cannabidiol (CBD), tetrahydrocannabivarin (THCV), cannabinol (CBN), Δ9-trans-tetrahydrocannabinol (Δ9-THC), Δ8- trans-tetrahydrocannabinol (Δ8-THC), cannabicyclol (CBL), cannabichromene (CBC), and Δ9-tetrahydrocannabinolic acid-A (THCAA). The analysis was carried out on the biomass and extracts of these varieties. Methanol–chloroform (9:1, v/v) was used for ext

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Motiejauskaitė, Dovilė, Sana Ullah, Algimanta Kundrotaitė, Renata Žvirdauskienė, Aušra Bakšinskaitė, and Karolina Barčauskaitė. "Isolation of Biologically Active Compounds from Cannabis sativa L. Inflorescences by Using Different Extraction Solvents and Evaluation of Antimicrobial Activity." Antioxidants 12, no. 5 (2023): 998. http://dx.doi.org/10.3390/antiox12050998.

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Hemp inflorescences are a source of vital compounds, including phytocannabinoids and other biologically active compounds. Various methods are adapted for the extraction of these vital compounds such as the use of different organic solvents. This study aimed to assess the comparative extraction potential of three different solvents: deionized water, 70% methanol (MeOH), and 2% Triton X-100, for phytochemicals in hemp inflorescences. Spectrophotometric techniques were applied to investigate the total amount of polyphenolic compounds (TPC), total flavonoids contents (TF), phenolic acids (TPA), an

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Finn, Michael A., Daniel R. Fassett, Todd D. Mccall, Randy Clark, Andrew T. Dailey, and Darrel S. Brodke. "The cervical end of an occipitocervical fusion: a biomechanical evaluation of 3 constructs." Journal of Neurosurgery: Spine 9, no. 3 (2008): 296–300. http://dx.doi.org/10.3171/spi/2008/9/9/296.

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Object Stabilization with rigid screw/rod fixation is the treatment of choice for craniocervical disorders requiring operative stabilization. The authors compare the relative immediate stiffness for occipital plate fixation in concordance with transarticular screw fixation (TASF), C-1 lateral mass and C-2 pars screw (C1L-C2P), and C-1 lateral mass and C-2 laminar screw (C1L-C2L) constructs, with and without a cross-link. Methods Ten intact human cadaveric spines (Oc–C4) were prepared and mounted in a 7-axis spine simulator. Each specimen was precycled and then tested in the intact state for fl

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Zolotarev, Dmitriy P., Ivan S. Shegutov, and Natalia E. Berdnikova. "Maltinka 1 - a Little-Known Late Paleolithic Site Near the Malta (South of Baikal-Yenisei Siberia)." Herald of Omsk University. Series: Historical studies 10, no. 4 (40) (2023): 157–67. http://dx.doi.org/10.24147/2312-1300.2023.10(4).157-167.

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The article describes the study results of the little-known Upper Paleolithic site Maltinka 1, located on the Belaya River (left tributary of the Angara River) in the vicinity of the world-famous Malta Paleolithic site. It was discovered in 1929 by Mikhail Gerasimov and studied in 1977, 1983 by Irina Lezhnenko. In the deposits of MIS 2 and MIS 1, 4 cultural layers (c.l.) were identified. Their estimated age is as follows: c.l. 1 - 7-1 ka cal BP; c.l. 2 - ~14.7-12.8 ka cal BP; c.l. 3 - ~18.6-17.6 ka cal BP; c.l. 4 - ~27-25 ka cal BP. Layers 1 and 4 are not very informative. The finds of layer 2

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12

Herman, Sarah E. M., Amber L. Gordon, Amy J. Wagner та ін. "Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals". Blood 116, № 12 (2010): 2078–88. http://dx.doi.org/10.1182/blood-2010-02-271171.

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Abstract Targeted therapy with imatinib in chronic myeloid leukemia (CML) prompted a new treatment paradigm. Unlike CML, chronic lymphocytic leukemia (CLL) lacks an aberrant fusion protein kinase but instead displays increased phosphatidylinositol 3-kinase (PI3K) activity. To date, PI3K inhibitor development has been limited because of the requirement of this pathway for many essential cellular functions. Identification of the hematopoietic-selective isoform PI3K-δ unlocks a new therapeutic potential for B-cell malignancies. Herein, we demonstrate that PI3K has increased enzymatic activity and

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13

Badger-Brown, Karla M., Monica L. Bailey, Josef Penninger, and Dwayne L. Barber. "Cbl-b Deficiency Enhances Motility and Impairs Leukemogenesis by Bcr-Abl." Blood 110, no. 11 (2007): 1019. http://dx.doi.org/10.1182/blood.v110.11.1019.1019.

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Abstract One of the prominent tyrosine phosphorylated substrates of BCR-ABL identified in cells from chronic-phase Chronic Myeloid Leukemia (CML) patients is the Cbl ubiquitin ligase and adaptor protein. Bone marrow transplantation studies have revealed that Cbl is dispensable for CML development, as animals receiving Cbl-deficient bone marrow cells expressing BCR-ABL develop a myeloproliferative disease (MPD) with a similar latency and phenotype as wild type bone marrow recipients (Dinulescu et al. 22: 8852–60, 2003). Cbl belongs to a family of E3 ubiquitin ligases that also contains Cbl-b an

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14

Makishima, Hideki, Anna M. Jankowska, Heather Cazzolli, et al. "Cbl and TET2 Mutations Are Present in Refractory Ph+ Disorders Including Accelerated and Blast Crisis CML and ALL." Blood 114, no. 22 (2009): 2173. http://dx.doi.org/10.1182/blood.v114.22.2173.2173.

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Abstract Abstract 2173 Poster Board II-150 Loss of heterozygosity (LOH) due to acquired uniparental disomy (UPD) is a commonly observed chromosomal lesion in myeloproliferative neoplasms (MPN) and myelodysplastic/myeloproliferative neoplasms (MDS/MPN) including chronic myelomonocytic leukemia (CMML). Most recurrent areas of LOH point towards genes harboring mutations. For example, UPD11q23.3 and UPD4q24 were found to be associated with c-Cbl and TET2 mutations, respectively. Cbl family mutations (c-Cbl and Cbl-b) have been associated with atypical MDS/MPN including CMML and juvenile myelomonoc

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15

Mao, Jianhua, Xiaoyan Sun, Qun-Ye Zhang, et al. "E3 Ligase c-CBL Mediates Ubiquitination-Proteasomal Degradation of BCR-ABL and Therapeutic Effects against BCR-ABL Leukemia." Blood 114, no. 22 (2009): 3257. http://dx.doi.org/10.1182/blood.v114.22.3257.3257.

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Abstract Abstract 3257 Poster Board III-1 We previously demonstrated that the cellular level of the fusion oncoprotein BCR-ABL in chronic myelogenous leukemia (CML) could be regulated by the proteolysis via ubiquitin-proteasome pathway and arsenic sulfide (As4S4) could enhance this process to exert therapeutic effects against CML. However, the exact biochemical mechanism and molecules involved, including the ubiquitin E3 ligases of BCR-ABL, their modification sites and the topologic type of ubiquitination remain uncovered. In this work, by using immunoprecipitation (IP) /2D-nano-HPLC/MALDI-TOF

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16

Syed, Mustafaa M., M. Sathish, S. Nivedha, Magribatul Noora A. K. Mohammed, and Sifana T. Safrin. "Design of Carry Select Adder using BEC and Common Boolean Logic." Indian Journal of VLSI Design (IJVLSID) 1, no. 3 (2022): 5–9. https://doi.org/10.54105/ijvlsid.C1205.031322.

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Carry Select Adder (CSLA) is known to be the fastest adder among the conventional adder structure, which uses multiple narrow adders. CSLA has a great scope of reducing area, power consumption, speed and delay. From the structure of regular CSLA using RCA, it consumes large area and power. This proposed work uses a simple and dynamic Gate Level Implementation which reduces the area, delay, power and speed of the regular CSLA. Based on a modified CSLA using BEC the implementation of 8-b, 16-b, 32-b square root CSLA (SQRT CSLA) architecture have been developed. In order to reduce the area and po

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Tregoat, Claire, Romain Gioia, Valérie Lagarde, et al. "Cbl Controls the Expression of Axl and Lyn Tyrosine Kinases Mediating Resistance to Nilotinib in Chronic Myeloid Leukemia Cells." Blood 120, no. 21 (2012): 3734. http://dx.doi.org/10.1182/blood.v120.21.3734.3734.

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Abstract Abstract 3734 The second generation of Abl tyrosine kinase inhibitor (TKI) nilotinib has been developed to overcome resistance to imatinib, which was up to now the gold standard treatment of chronic myeloid leukemia (CML). Although nilotinib has been approved recently as the front line treatment of CML, there are still some unresponsiveness nilotinib CML cells. The generation of nilotinib-resistant K562 CML cells led us to characterize the underlying mechanism regulating one of such cell resistance. We have previously shown that overexpression of the Lyn tyrosine kinase (TK) could exp

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18

Goyama, Susumu, Janet Schibler, and James C. Mulloy. "C-CBL Inactivation Promotes Cytokine-Driven Growth of Human CD34+ Cells and AML1-ETO Expressing Cells." Blood 118, no. 21 (2011): 2464. http://dx.doi.org/10.1182/blood.v118.21.2464.2464.

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Abstract Abstract 2464 C-CBL is an E3 ubiquitin ligase and negatively regulates activated receptor tyrosine kinases. C-CBL mutations have been frequently found in a variety of myeloid neoplasms, most frequently in chronic myelomonocytic leukemia (CMML) and juvenile myelomonocytic leukemia (JMML). The mutations occur almost exclusively in exons 8–9 that encode linker/RING finger domains, which result in loss of E3 ligase activity. These mutants are considered to have dominant-negative function over the wild-type C-CBL. In acute myeloid leukemia (AML), C-CBL mutations are associated with core bi

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Hajrulai-Musliu, Zehra, Elizabeta Dimitreska Stojkovikj, Dimitar Gusheski, Dea Musliu, and Daniel Velkovski. "High-Performance Liquid Chromatography with DAD Detection for the Determination of Cannabinoids in Commercial Veterinary CBD Oil." Pharmacy 12, no. 6 (2024): 181. https://doi.org/10.3390/pharmacy12060181.

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The study highlights the need for quality control in evaluating medicinal plant products, especially CBD oils, before market release. Due to varying regulatory requirements, product labeling can sometimes be misleading, especially regarding cannabinoid concentrations such as CBD and THC. This research focused on developing a validated high-performance liquid chromatography (HPLC) method for accurately identifying and quantifying key cannabinoids in Commercial Veterinary CBD Oil. The main compounds identified included Cannabidivarin (CBDV), Cannabidiolic Acid (CBD-A), Cannabigerolic Acid (CBG-A

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Difilippo, Emma Catherine, Alejandro Ferrer, Laura Schultz-Rogers, et al. "Spectrum of Hematological Malignancies in 130 Patients with Germline Predisposition Syndromes - Mayo Clinic Germline Predisposition Study." Blood 136, Supplement 1 (2020): 34–35. http://dx.doi.org/10.1182/blood-2020-139050.

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Introduction Germline predisposition syndromes (GPS) are inherited disorders associated with germinal aberrations that increase the risk of malignancies. While aberrations in certain genes increase the risk for all types of malignancies (Tp53, ATM, CDKN2A, CHEK2), there is a growing list of genes associated specifically with hematological malignancies (GATA2, RUNX1, DDX41, ETV6, ANKRD26). At our institution, we have established a hematology GPS clinic to diagnose and manage GPS and with this report, detail our experience with 130 patients. Methods GPS were investigated in pediatric and adult p

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Liu, Yun-Cai, and Amnon Altman. "Cbl." Cellular Signalling 10, no. 6 (1998): 377–85. http://dx.doi.org/10.1016/s0898-6568(97)00179-4.

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22

Mao, Jian-Hua, Xiao-Yan Sun, Jian-Xiang Liu, et al. "Arsenic Sulfide Binds c-CBL to Promote BCR-ABL Ubiquitination and Degradation In Chronic Myelogenous Leukemia." Blood 116, no. 21 (2010): 1200. http://dx.doi.org/10.1182/blood.v116.21.1200.1200.

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Abstract Abstract 1200 Using immunoprecipitation (IP)-2D-nano-HPLC-MALDI-MS-MS, we identified c-CBL in association with BCR-ABL in a multi-protein complex in K562 cells. In vitro ubiquitination and mutagenesis analyses show that c-CBL serves as a specific E3 ligase for ubiquitination of BCR-ABL at K1517. Arsenic sulfide (As4S4) treatment results in increased c-CBL protein level, which promotes ubiquitination and subsequent degradation of BCR-ABL and apoptosis of K562 cells. Elevated c-CBL is necessary and sufficient to recapitulate the effect of As4S4. Interestingly, arsenic directly binds the

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Makishima, Hideki, Anna M. Jankowska, Michael A. McDevitt, et al. "CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia." Blood 117, no. 21 (2011): e198-e206. http://dx.doi.org/10.1182/blood-2010-06-292433.

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Abstract Progression of chronic myelogenous leukemia (CML) to accelerated (AP) and blast phase (BP) is because of secondary molecular events, as well as additional cytogenetic abnormalities. On the basis of the detection of JAK2, CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations in myelodysplastic/myeloproliferative neoplasms, we hypothesized that they may also contribute to progression in CML. We screened these genes for mutations in 54 cases with CML (14 with chronic phase, 14 with AP, 20 with myeloid, and 6 with nonmyeloid BP). We identified 1 CBLB and 2 TET2 mutations in AP, and 1 CBL, 1 CBLB,

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Weinberg, J. Brice, Youwei Chen, John C. Salerno, and Dipak K. Ghosh. "Inhibition of Nitric Oxide Synthase (NOS) 1, NOS2, and NOS3 Enzymatic Activities by Vitamin B12 and Related Corrins: Biochemical and Molecular Modeling Studies." Blood 110, no. 11 (2007): 2663. http://dx.doi.org/10.1182/blood.v110.11.2663.2663.

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Abstract Cobalamins (Cbl) serve as important co-factors for methionine synthase and methylmalonyl-coA mutase. They also can block the activities of NO, as the cobalt in cobalamin binds NO and quenches its bioactivity. NO plays very important roles in normal physiology and in various pathologic processes. NO is synthesized by NO synthases (NOS), enzymes that convert L-arginine to L-citrulline and NO. We postulated that various corrin derivatives (e.g., cobalamins or cobinamides) would inhibit the enzymatic activity of NO synthase (NOS) by directly interacting with NOS. We used purified, recombi

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Hanuš, Lumír O., Rina Levy, Dafna De La Vega, Limor Katz, Michael Roman, and Pavel Tomíček. "The main cannabinoids content in hashish samples seized in Israel and Czech Republic." Israel Journal of Plant Sciences 63, no. 3 (2016): 182–90. http://dx.doi.org/10.1080/07929978.2016.1177983.

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Cannabis, both herbal and resin, has been the most popular illicit drug in Israel in recent years. Until 2005, the main sources of cannabis resin (known also as hashish) to the Israeli drug market were Lebanon and India. Hashish from these sources can be distinguished by its external appearance. The aim of this study was to determine if there is any difference in the quality of the hashish from each source. For this purpose, we quantified the main cannabinoids, cannabidiol (CBD), Δ9-tetrahydrocannabinol (Δ9-THC), and cannabinol (CBN) of hashish from different police seizures of known origins,

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Sonoda, Noriyuki, Mikio Furuse, Hiroyuki Sasaki, et al. "Clostridium perfringens Enterotoxin Fragment Removes Specific Claudins from Tight Junction Strands." Journal of Cell Biology 147, no. 1 (1999): 195–204. http://dx.doi.org/10.1083/jcb.147.1.195.

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Claudins, comprising a multigene family, constitute tight junction (TJ) strands. Clostridium perfringens enterotoxin (CPE), a single ∼35-kD polypeptide, was reported to specifically bind to claudin-3/RVP1 and claudin-4/CPE-R at its COOH-terminal half. We examined the effects of the COOH-terminal half fragment of CPE (C-CPE) on TJs in L transfectants expressing claudin-1 to -4 (C1L to C4L, respectively), and in MDCK I cells expressing claudin-1 and -4. C-CPE bound to claudin-3 and -4 with high affinity, but not to claudin-1 or -2. In the presence of C-CPE, reconstituted TJ strands in C3L cells

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Jo, Young Soo, and Joo Ho Kang. "Interpolation Problems in CSL-Algebra ALG${\cal L}$." Rocky Mountain Journal of Mathematics 33, no. 3 (2003): 903–14. http://dx.doi.org/10.1216/rmjm/1181069934.

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Tran, Jonathan, Aaron C. Elkins, German C. Spangenberg, and Simone J. Rochfort. "High-Throughput Quantitation of Cannabinoids by Liquid Chromatography Triple-Quadrupole Mass Spectrometry." Molecules 27, no. 3 (2022): 742. http://dx.doi.org/10.3390/molecules27030742.

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The high-throughput quantitation of cannabinoids is important for the cannabis industry. As medicinal products increase, and research into compounds that have pharmacological benefits increase, and the need to quantitate more than just the main cannabinoids becomes more important. This study aims to provide a rapid, high-throughput method for cannabinoid quantitation using a liquid chromatography triple-quadrupole mass spectrometer (LC-QQQ-MS) with an ultraviolet diode array detector (UV-DAD) for 16 cannabinoids: CBDVA, CBDV, CBDA, CBGA, CBG, CBD, THCV, THCVA, CBN, CBNA, THC, Δ8-THC, CBL, CBC,

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Hoellenriegel, Julia, Sarah A. Meadows, William G. Wierda, Michael J. Keating, Brian Lannutti, and Jan A. Burger. "Phosphoinositide 3’-Kinase (PI3K) Delta Inhibition with CAL-101 Blocks B-Cell Receptor (BCR) Signaling and the Prosurvival Actions of Nurslike Cells (NLC), In Chronic Lymphocytic Leukemia." Blood 116, no. 21 (2010): 48. http://dx.doi.org/10.1182/blood.v116.21.48.48.

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Abstract Abstract 48 BCR signaling is increasingly recognized as a central mechanism for disease progression in CLL. PI3K transmits various external, microenvironment-derived signals that influence survival, drug resistance, and cell migration of CLL cells. PI3K isoforms have distinct functions and tissue distributions. P110δ mutant mice display defective BCR signaling, along with impaired B cell development and differentiation. Because of this unique role of p110δ in BCR signaling, p110δ inhibitors have been developed for treatment of B cell malignancies and autoimmune disorders. CAL-101, a p

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Meisner, H., A. Daga, J. Buxton, et al. "Interactions of Drosophila Cbl with epidermal growth factor receptors and role of Cbl in R7 photoreceptor cell development." Molecular and Cellular Biology 17, no. 4 (1997): 2217–25. http://dx.doi.org/10.1128/mcb.17.4.2217.

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The human proto-oncogene product c-Cbl and a similar protein in Caenorhabditis elegans (Sli-1) contain a proline-rich COOH-terminal region that binds Src homology 3 (SH3) domains of proteins such as the adapter Grb2. Cb1-Grb2 complexes can be recruited to tyrosine-phosphorylated epidermal growth factor (EGF) receptors through the SH2 domain of Grb2. Here we identify by molecular cloning a Drosophila cDNA encoding a protein (Drosophila Cbl [D-Cbl]) that shows high sequence similarity to the N-terminal region of human c-Cbl but lacks proline-rich sequences and fails to bind Grb2. Nonetheless, in

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Farsi, Ali, Pratik H. Lodha, Jennifer E. Skanes, Heidi Los, Navya Kalidindi та Susan M. Aitken. "Interconversion of a pair of active-site residues in Escherichia coli cystathionine γ-synthase, E. coli cystathionine β-lyase, and Saccharomyces cerevisiae cystathionine γ-lyase and development of tools for the investigation of their mechanisms and reaction specificity". Biochemistry and Cell Biology 87, № 2 (2009): 445–57. http://dx.doi.org/10.1139/o08-144.

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Cystathionine γ-synthase (CGS) and cystathionine β-lyase (CBL), which comprise the transsulfuration pathway of bacteria and plants, and cystathionine γ-lyase (CGL), the second enzyme of the fungal and animal reverse transsulfuration pathway, share ∼30% sequence identity and are almost indistinguishable in overall structure. One difference between the active site of Escherichia coli CBL and those of E. coli CGS and Saccharomyces cerevisiae CGL is the replacement of a pair of aromatic residues, F55 and Y338, of the former by acidic residues in CGS (D45 and E325) and CGL (E48 and E333). A series

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Sagliano, Michael, Timothy Stewart, and Julie Sagliano. "Professional Training to Develop Content-Based Instruction in Higher Education." TESL Canada Journal 16, no. 1 (1998): 36. http://dx.doi.org/10.18806/tesl.v16i1.709.

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Many TESL professionals have not had training specifically in content-based instruction (CBl) methodology. The lack of professional training in CBl is increasingly problematic as the number of programs adopting some content-based methodology continues to rise. One obvious response to this gap in pedagogical training could be for institutions engaging in CBl to create their own professional orientation programs for experienced faculty members. This article describes one such response at a Japanese university. Drawing on our four years' experience in developing a specific CBI teacher training pr

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Makishima, Hideki, Heather Cazzolli, Hadrian Szpurka, et al. "Mutations of E3 Ubiquitin Ligase Cbl Family Members Constitute a Novel Common Pathogenic Lesion in Myeloid Malignancies." Journal of Clinical Oncology 27, no. 36 (2009): 6109–16. http://dx.doi.org/10.1200/jco.2009.23.7503.

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Purpose Acquired somatic uniparental disomy (UPD) is commonly observed in myelodysplastic syndromes (MDS), myelodysplastic/myeloproliferative neoplasms (MDS/MPN), or secondary acute myelogenous leukemia (sAML) and may point toward genes harboring mutations. Recurrent UPD11q led to identification of homozygous mutations in c-Cbl, an E3 ubiquitin ligase involved in attenuation of proliferative signals transduced by activated receptor tyrosine kinases. We examined the role and frequency of Cbl gene family mutations in MPN and related conditions. Methods We applied high-density SNP-A karyotyping t

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Hoellenriegel, Julia, Sarah A. Meadows, Mariela Sivina, et al. "The phosphoinositide 3′-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia." Blood 118, no. 13 (2011): 3603–12. http://dx.doi.org/10.1182/blood-2011-05-352492.

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Abstract In lymphocytes, the phosphoinositide 3′-kinase (PI3K) isoform p110δ (PI3Kδ) transmits signals from surface receptors, including the B-cell receptor (BCR). CAL-101, a selective inhibitor of PI3Kδ, displays clinical activity in CLL, causing rapid lymph node shrinkage and a transient lymphocytosis. Inhibition of pro-survival pathways, the presumed mechanism of CAL-101, does not explain this characteristic pattern of activity. Therefore, we tested CAL-101 in assays that model CLL-microenvironment interactions in vitro. We found that CAL-101 inhibits CLL cell chemotaxis toward CXCL12 and C

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Keane, Maccon M., Seth A. Ettenberg, Marion M. Nau, et al. "cbl-3: a new mammalian cbl family protein." Oncogene 18, no. 22 (1999): 3365–75. http://dx.doi.org/10.1038/sj.onc.1202753.

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Liu, Yun-Cai, and Hua Gu. "Cbl and Cbl-b in T-cell regulation." Trends in Immunology 23, no. 3 (2002): 140–43. http://dx.doi.org/10.1016/s1471-4906(01)02157-3.

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Fiorcari, Stefania, Wells S. Brown, Bradley W. McIntyre та ін. "The PI3 Kinase δ Inhibitor, CAL-101 (GS-1101), Inhibits Chronic Lymphocytic Leukemia (CLL) Cell Survival in Endothelial and Marrow Stromal Cell Co-Cultures." Blood 118, № 21 (2011): 1769. http://dx.doi.org/10.1182/blood.v118.21.1769.1769.

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Abstract Abstract 1769 CLL cells are characterized by their ability to resist apoptosis in vivo, but in vitro they undergo spontaneous apoptosis. This suggests that interactions between CLL cells and accessory cells in the tissue microenvironments, such as mesenchymal stromal cells (MSC), nurselike cells (NLC), T-cells, and endothelial cells are critical for maintaining CLL cell survival. CLL cells display constitutive PI3K pathway activation, presumable due to CLL interactions with the microenvironment. CAL-101 is a potent and selective inhibitor of the p110d PI3K isoform and has shown promis

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Zeng, Shan, Zhiheng Xu, Stan Lipkowitz, and Jack B. Longley. "Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl)." Blood 105, no. 1 (2005): 226–32. http://dx.doi.org/10.1182/blood-2004-05-1768.

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Abstract Activation of the KIT receptor tyrosine kinase contributes to the pathogenesis of several human diseases, but the mechanisms regulating KIT signaling have not been fully characterized. Here, we show that stem cell factor (SCF), the ligand for KIT, induces the interaction between KIT and Cbl proteins and their mutual degradation. Upon SCF stimulation, KIT binds to and induces the phosphorylation of Cbl proteins, which in turn act as E3 ligases, mediating the ubiquitination and degradation of KIT and themselves. Tyrosine kinase binding and RING finger domains of Cbl are essential for Cb

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Byrd, John C., Jennifer A. Woyach, and Amy J. Johnson. "Translating PI3K-Delta Inhibitors to the Clinic in Chronic Lymphocytic Leukemia: The Story of CAL-101 (GS1101)." American Society of Clinical Oncology Educational Book, no. 32 (June 2012): 691–94. http://dx.doi.org/10.14694/edbook_am.2012.32.75.

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Overview: Targeted therapy with imatinib has transformed the treatment of chronic myeloid leukemia (CML). Unlike CML, chronic lymphocytic leukemia (CLL) lacks a common genetic aberration but does demonstrate constitutive activation of PI3-kinase (PI3K) as compared to normal B cells. This constitutively active PI3K in CLL likely relates to tonic B-cell receptor signaling that is present across a wide variety of B-cell malignancies. Although PI3K is quite proximal and represents an ideal target to pharmacologically modulate, the complexity of this pathway on which many normal functions are depen

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Weinberg, J. Brice, Youwei C. Chen, Bethany E. Beasley, and Dipak K. Ghosh. "Cobalamins and Cobinamides Inhibit Nitric Oxide Synthase Enzymatic Activity." Blood 106, no. 11 (2005): 2225. http://dx.doi.org/10.1182/blood.v106.11.2225.2225.

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Abstract Cobalamins (Cbl) serve as important co-factors for methionine synthase and methylmalonyl-coA mutase. They also can block the activities of nitric oxide (NO), as the cobalt binds NO and quenches its bioactivity. NO plays very important roles in normal physiology and in various pathologic processes. NO is synthesized by NO synthases (NOS), enzymes that convert L-arginine to L-citrulline and NO. We postulated that various corrin derivatives (e.g., cobalamins or cobinamides) would inhibit the enzymatic activity of NO synthase (NOS) by directly interacting with NOS. We used purified, recom

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Wu, Ji, Feng Meng, Henry Lu, et al. "Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells." Blood 111, no. 7 (2008): 3821–29. http://dx.doi.org/10.1182/blood-2007-08-109330.

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Abstract Lyn kinase functions as a regulator of imatinib sensitivity in chronic myelogenous leukemia (CML) cells through an unknown mechanism. In patients who fail imatinib therapy but have no detectable BCR-ABL kinase mutation, we detected persistently activated Lyn kinase. In imatinib-resistant CML cells and patients, Lyn activation is BCR-ABL independent, it is complexed with the Gab2 and c-Cbl adapter/scaffold proteins, and it mediates persistent Gab2 and BCR-ABL tyrosine phosphorylation in the presence or absence of imatinib. Lyn silencing or inhibition is necessary to suppress Gab2 and B

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Kai, Xin, Vasant Chellappa, Jesse Moya, et al. "Defective Inhibitory Signaling in CLL B Cells and Increased Recruitment of PI3K by c-Cbl in Zap-70+ CLL." Blood 114, no. 22 (2009): 1258. http://dx.doi.org/10.1182/blood.v114.22.1258.1258.

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Abstract Abstract 1258 Poster Board I-280 Background An inhibitory signaling pathway involving sialic acid 9-O-acetyl esterase (SIAE), sialic acid binding lectins (Siglecs) particularly Siglec-2/CD22, the Lyn tyrosine kinase, and the SH2 domain containing tyrosine phosphatase, SHP-1, attenuates B cell receptor signaling and sets a threshold for B cell activation. A key step in the process is the requirement that SIAE access N-glycans on Siglec ligands and remove 9-O-acetyl groups from terminal αa2,6 linked sialic acid moieties. Siglec-ligand interaction is followed by phosphorylation of ITIM t

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Mulligan, Stephen P., Jane A. Freeman, Xavier Badoux, et al. "Randomized Trial in Unfit, Elderly Chronic Lymphocytic Leukemia (CLL) Patients with Comorbidities of Dose-Reduced Oral Fludarabine and Cyclophosphamide Plus Obinutuzumab (FC+G) Versus Chlorambucil Plus Obinutuzumab (Cbl+G) As Front-Line Therapy." Blood 132, Supplement 1 (2018): 3144. http://dx.doi.org/10.1182/blood-2018-99-116287.

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Abstract BACKGROUND The prior Australasian Leukaemia and Lymphoma Group (ALLG) CLL5 Study showed dose-reduced oral fludarabine and cyclophosphamide plus rituximab (FCR3) was safe, tolerable and effective in fit elderly patients for front-line therapy for CLL. The German CLL11 Study showed chlorambucil plus obinutuzumab (Cbl+G) was superior to chlorambucil alone or with rituximab in unfit patients requiring initial therapy. We conducted a randomized study to assess the safety, tolerability, and efficacy of dose-reduced FC + obinutuzumab (G) (FC+G) versus Cbl+G in unfit (i.e. with comorbidity),

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Davids, Matthew S., Brian J. Lannutti, Jennifer R. Brown, and Anthony G. Letai. "BH3 Profiling Demonstrates That Restoration of Apoptotic Priming Contributes to Increased Sensitivity to PI3K Inhibition in Stroma-Exposed Chronic Lymphocytic Leukemia Cells." Blood 118, no. 21 (2011): 974. http://dx.doi.org/10.1182/blood.v118.21.974.974.

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Abstract 974 We and others have previously found that CLL cells exposed to stroma are resistant to a wide variety of treatments. While this phenomenon is thought largely to be due to inhibition of apoptosis, this has not been directly tested. BH3 profiling was developed in our laboratory as a functional assay to assess the degree to which malignant cells are primed to undergo apoptosis via the mitochondrial pathway. BH3 profiling demonstrates that decreased priming for apoptosis is indeed associated with treatment resistance in CLL cells co-cultured with mouse fibroblast L cells. Here, we conf

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Guarnera, Luca, Carmelo Gurnari, Carlos Bravo-Perez, et al. "Molecular Landscape of c-CBL Mutation in Adults' Myeloid Malignancies." Blood 142, Supplement 1 (2023): 4336. http://dx.doi.org/10.1182/blood-2023-184962.

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Background: CBL proteins are a family of RING finger (RF) E3 ubiquitin ligases that regulate proliferative signals via ubiquitination and degradation of tyrosine-phosphorylated signaling protein ( e.g., FLT3, JAK2, MPL). Thus, the loss of CBL activity due to hypomorphic or loss of function (LOF) mutations functionally may result in oncogenic effects. However, simple LOF does not explain the high rates of c-CBL (most abundant CBL isoform, located on chromosome 11)missensemutations affecting a canonical position in the RF domain, catalytic region responsible for ubiquitin ligase activity. We hyp

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Chen, Liguang, Lang Huynh, John Apgar, et al. "ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia." Blood 111, no. 5 (2008): 2685–92. http://dx.doi.org/10.1182/blood-2006-12-062265.

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We transduced chronic lymphocytic leukemia (CLL) cells lacking ZAP-70 with vectors encoding ZAP-70 or various mutant forms of ZAP-70 and monitored the response of transduced CLL cells to treatment with F(ab)2 anti-IgM (anti-μ). CLL cells made to express ZAP-70, a kinase-defective ZAP-70 (ZAP-70-KA369), or a ZAP-70 unable to bind c-Cbl (ZAP-YF292) experienced greater intracellular calcium flux and had greater increases in the levels of phosphorylated p72Syk, B-cell linker protein (BLNK), and phospholipase C-γ, and greater activation of the Ig accessory molecule CD79b in response to treatment wi

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V, Shasi Kiran Reddy, Digbijaya Swain, Saswaty Priyadarshini Sahoo, et al. "Combining ability and heterosis for grain yield and yield component traits in maize (Zea mays L.)." Electronic Journal of Plant Breeding 15, no. 4 (2024): 927–34. https://doi.org/10.37992/2024.1504.112.

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Abstract The present investigation was conducted on maize hybrids to determine the extent of heterosis and combining ability for 12 quantitative traits including yield and its contributing traits during Kharif, 2021. A set of 28 F1s developed by 8 x 8 half diallel mating design and the resultant hybrids along with parents and standard checks were evaluated in Randomised Block Design (RBD) with three replications. For standard heterosis over hybrid Bio 9544 ranged from 11.10 to 44.86 % and four F1 cross combinations (SNL 142828-4 x CML 451, CAL 1473-4 x CML 451, CAL 1424-1 x CML 470-1 and SNL 1

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Galanda, Jozef, Radoslav Šulej, and Martin Jezný. "Virtualan koncept simbiotičkog okruženja CBL i CBT metoda obrazovanja u sustavu zrakoplovstva." Naše more 63, no. 3 (2016): 244–48. http://dx.doi.org/10.17818/nm/2016/si31.

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Liu, Shaqian, Rui Yang, Chunlan Hou, Jiarui Guo, and Juebing Ma. "Effects of the Decomposition of Mixed Plant Residues in Ecological Tea Garden Soil." Agronomy 12, no. 11 (2022): 2717. http://dx.doi.org/10.3390/agronomy12112717.

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(1) Background: Plant litter decomposition and its effect on soil nutrients are important parts of the ecosystem material cycle, and understanding these processes is key for species selection and allocation, to promote the effective use of litter in ecological tea gardens. (2) Methods: In situ decomposition was used in this study Changes in decomposition rate, element release, and soil properties during the decomposition of the mixed plant residues were measured. (3) Results: The decomposition rate (k) of the CCG (Camellia sinensis + Cinnamomum glanduliferum) mixed plant residue was significan

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Niro, Antonio, Rocco Piazza, Gabriele Merati, et al. "ETNK1 Is an Early Event and SETBP1 a Late Event in Atypical Chronic Myeloid Leukemia." Blood 126, no. 23 (2015): 3652. http://dx.doi.org/10.1182/blood.v126.23.3652.3652.

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Abstract Atypical Chronic Myeloid Leukemia (aCML) is a clonal disorder belonging to the myelodisplastic-myeloproliferative neoplasms, according to the WHO-2008 classification. From a clinical point of view it closely resembles the classical Chronic Myeloid Leukemia (CML), however it lacks the presence of the Philadelphia chromosome and of the BCR-ABL1 fusion gene. In recent works, we and others characterized the somatic lesions present in the aCML genome, mainly by using Next Generation Sequencing (NGS) technologies, demonstrating the presence of a large set of recurrent somatic mutations invo

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