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Dissertations / Theses on the topic 'CTCFL'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Dienstbach, Sven [Verfasser]. "Identifizierung der CTCFL-Bindestellen in NIH3T3-Zellen und Einfluss der CTCFL-Expression auf die globale Genexpression / Sven Dienstbach." Gießen : Universitätsbibliothek, 2013. http://d-nb.info/1064992293/34.

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2

Bergmaier, Philipp Franz Hermann [Verfasser]. "Analyse des genom-weiten Bindeverhaltens des Faktors CTCFL / Philipp Franz Hermann Bergmaier." Gießen : Universitätsbibliothek, 2016. http://d-nb.info/1116894564/34.

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3

Bergmaier, Philipp [Verfasser]. "Analyse des genom-weiten Bindeverhaltens des Faktors CTCFL / Philipp Franz Hermann Bergmaier." Gießen : Universitätsbibliothek, 2016. http://d-nb.info/1116894564/34.

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4

Alkhatib, Shaza. "Investigation of the immunological differences between granulocytes from healthy donors and breast cancer patients, with respect to the cancer testis antigen, CTCFL." Thesis, University of Essex, 2015. http://repository.essex.ac.uk/16454/.

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Granulocytes or Polymorphonuclear neutrophils (PMNs) are key players in the non-specific immune system against microbial infection as they express surface receptors for the recognition of general antigenic patterns found on pathogens. In addition PMN’s also act as a mediator for the antigen-specific adaptive immunity and T-cells function. However, an anti-tumoral role of the PMN’s was suggested over the recent years beside their well-studied innate function, opening the door for new studies in this area. CTCFL or BORIS (Brother Of the Regulator of the Imprinting Site) is a paralogue protein to

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5

Rai, Sushma Debi. "Tumour specific CTCF point mutations abrogate CTCF function." Thesis, University of Essex, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442523.

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6

Kung, Johnny Tsun-Yi. "Genome-wide Analysis of Ctcf-RNA Interactions." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11618.

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Ctcf is a "master regulator" of the genome that plays a role in a variety of gene regulatory functions as well as in genome architecture. Evidence from studying the epigenetic process of X-chromosome inactivation suggests that, in certain cases, Ctcf might carry out its functions through interacting with RNA. Using mouse embryonic stem (ES) cells and a modified protocol for UV-crosslinking and immunoprecipitation followed by high-throughput sequencing (CLIP-seq), Ctcf is found to interact with a multitude of transcripts genome-wide, both protein-coding mRNA (or noncoding transcripts therein) a

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7

Roberts, Julian Charles. "Identification and characterisation of novel DNA targets of the transcription factor CTCF and analysis of selected CTCF-DNA interactions." Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709829.

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8

Kita, Georgie-Xanthi. "Characterization of the CTCF isoforms and BORIS, the CTCF paralogue, in normal and cancer breast tissues and investigation of their role in breast tumourigenesis." Thesis, University of Essex, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.537934.

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9

Mukhopadhyay, Rituparna. "Chromatin Insulators and CTCF: Architects of Epigenetic States during Development." Doctoral thesis, Uppsala University, Department of Animal Development and Genetics, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4241.

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<p>A controlled and efficient coordination of gene expression is the key for normal development of an organism. In mammals, a subset of autosomal genes is expressed monoallelically depending on the sex of the transmitting parent, a phenomenon known as genomic imprinting.</p><p>The imprinted state of the <i>H19</i> and <i>Igf2</i> genes is controlled by a short stretch of sequences upstream of <i>H19</i> known as the imprinting control region (ICR). This region is differentially methylated and is responsible for the repression of the maternally inherited <i>Igf2</i> allele. It harbors hypersens

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10

Fischer, Sabine. "Inducible systems for the characterization of insulating and repressing motifs." kostenfrei, 2009. http://d-nb.info/999863568/34.

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11

Paris, Christian. "The role of CTCF in the life cycle of human papillomavirus." Thesis, University of St Andrews, 2014. http://hdl.handle.net/10023/6367.

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Papillomaviruses (PV) are epithelium specific DNA viruses that can cause health problems ranging from harmless warts to invasive cancer. Papillomavirus induced tumours most often arise in the cervix where human papillomavirus (HPV) infections were shown to cause 99.7 % of all malignancies. This study aims to map binding sites of the multifunctional host protein CCCTC binding factor (CTCF) to the papillomavirus genome, validate them and determine the function of CTCF in the papillomavirus life cycle. Computer predictions of CTCF binding sites in the sequence of 8 different PV revealed a CTCF bi

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12

Pant, Vinod. "CTCF and Epigenetic Regulation of the H19/Igf2 Locus." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3540.

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13

Heath, Helen Elizabeth. "CTCF: comprehending.the complex functions of an 11-zinc-finger transcription factor." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2007. http://hdl.handle.net/1765/10861.

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14

Nobelen, Suzanne van de. "Touched by CTCF analysis of a multi-functional zinc finger protein /." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2008. http://hdl.handle.net/1765/12282.

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15

El-Kady, A. "A study on regulation of a transcription factor CTCF, by phosphorylation." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275324.

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16

Panzer, Imke [Verfasser]. "Identifizierung und Analyse von Protein-Interaktionspartnern des Isolationsfaktors CTCF / Imke Panzer." Gießen : Universitätsbibliothek, 2012. http://d-nb.info/1063954177/34.

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17

Haag, Tanja [Verfasser]. "Epigenetische Untersuchung von Tumorsuppressorgenen und deren Regulation durch CTCF / Tanja Haag." Gießen : Universitätsbibliothek, 2015. http://d-nb.info/1069065501/34.

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18

Inoue, Lilian Tiemi. "Caracterização funcional da interação entre as proteínas CTSP-1 e CTCF." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-19012012-184051/.

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Os antígenos cancer-testis (CT) são proteínas imunogênicas expressas em tecido gametogênico e em diferentes tipos de tumor, sendo considerados candidatos promissores para a imunoterapia do câncer. Entretanto, pouco se sabe sobre a função desses antígenos na tumorigênese. Em 2006, identificamos CTSP-1 como um novo antígeno CT, frequentemente expresso em vários tumores. Nesse trabalho, investigamos a função de CTSP-1 por meio da identificação de proteínas expressas em tumores de próstata e que são capazes de interagir fisicamente com esse antígeno. Demonstramos que CTSP-1 interage com a prot

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19

Farrar, Dawn. "Investigation into the role of CTCF in the protection of breast cancer cells from apoptosis : identification of the different isoforms of CTCF and their possible function in apoptosis." Thesis, University of Essex, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422241.

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20

Liu, Lei [Verfasser], and Dieter [Akademischer Betreuer] Heermann. "Multiscale Modelling of CTCF and its Complexes / Lei Liu ; Betreuer: Dieter Heermann." Heidelberg : Universitätsbibliothek Heidelberg, 2015. http://d-nb.info/1180394976/34.

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21

Kang, Sung yun. "Investigation of the association in vivo between CTCF and RNA polymerase II." Thesis, University of Essex, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.446539.

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22

Aitken, Sarah Jane. "The pathological and genomic impact of CTCF depletion in mammalian model systems." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/284403.

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CCCTC-binding factor (CTCF) binds DNA, thereby helping to partition the mammalian genome into discrete structural and regulatory domains. In doing so, it insulates chromatin and fine-tunes gene activation, repression, and silencing. Complete removal of CTCF from mammalian cells causes catastrophic genomic dysregulation, most likely due to widespread collapse of 3D chromatin looping within the nucleus. In contrast, Ctcf hemizygous mice with lifelong reduction in CTCF expression are viable but have an increased incidence of spontaneous multi-lineage malignancies. In addition, CTCF is mutated in

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23

Langer, David [Verfasser]. "Kaiso und CTCF regulieren geprägte Gene in cis und in trans / David Langer." Mainz : Universitätsbibliothek Mainz, 2015. http://d-nb.info/1064721435/34.

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24

Pavlaki, Ioanna. "Role of CTCF Poly(ADP-ribosyl)ation in the regulation of cellular functions." Thesis, University of Essex, 2015. http://repository.essex.ac.uk/15691/.

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25

D'Arcy, V. "Investigation of CTCF and Boris in breast tumours and assessment of their clinical relevance." Thesis, University of Essex, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421148.

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26

Hanssen, Lars. "The role of elements binding CTCF and cohesin in directing tissue-specific enhancer activity." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:eb0f05e4-9563-4fd1-9814-841f1f2cb136.

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Distal enhancer elements regulate the tissue-specific expression of their target genes via the establishment of physical interactions with the gene promoter. In mice, a cluster of five enhancers, jointly classified as a super-enhancer, specifically upregulate α-globin gene expression during erythroid differentiation. Aside from the Nprl3 gene, whose promoter is located inside this enhancer region, expression-levels of other genes within a short distance (&lt,50kb) of the enhancer region are not affected by the activation of the enhancer in erythroid cells, despite being located within th

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27

Batlle, Ana. "Regulation of BCL6:p38 MAPK signalling and CTCF transcriptional regulation converge at exon 1." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/6093.

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BCL6 is a zinc finger transcriptional repressor, which is highly expressed in germinal centre B-cells, and is essential for germinal centre formation and T-dependent antibody responses. Deregulated BCL6 expression is associated with certain non- Hodgkin’s lymphomas. High expression is observed in breast cancer. Tight lineage and temporal regulation of BCL6 is, therefore, required for normal immunity and abnormal regulation occurs in cancer. Regulatory mechanisms have been analysed in two settings. Firstly, BCL6 is strongly induced by the tyrosine kinase inhibitor, Imatinib, in chronic myeloid

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28

Alharbi, Adel Braik M. "Characterising the Roles of Zinc Finger Proteins CTCF and ZRANB2 in Modulating Alternative Splicing." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/27996.

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Zinc finger (ZF) proteins constitute the most abundant protein class and are involved in multiple biological processes including development, differentiation, tumour suppression and apoptosis. CTCF and ZRANB2 are two ZF proteins that have been recently linked to modulation of alternative splicing (AS). AS is a complex biological process enriching transcriptome and proteome diversity by facilitating the production of multiple mRNA and protein isoforms from individual genes. However, the genome-wide impact of Ctcf and Zranb2 dosage on AS has not been investigated. The present study examined th

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29

Segueni, Julie. "DNA methylation changes CTCF binding and reorganizes 3D genome structure in breast cancer cells." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL020.

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Les génomes des mammifères adoptent une organisation 3D fonctionnelle où les interactions entre les enhancers et les promoteurs des gènes sont contenues à l'intérieur de domaines d'association topologique (TADs). La protéine insulatrice CTCF a deux rôles dans ce processus : sa liaison aux promoteurs permettant la formation de boucles enhancers-promoteurs (structure intra-TAD) et sa liaison aux frontières des TADs empêchant la formation de boucles ectopiques entre domaines voisins. Surtout, les perturbations de la liaison de la protéine CTCF à des sites particuliers dans des cellules cancéreuse

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30

Zielke, Katrin [Verfasser], and Andreas [Akademischer Betreuer] Burkovski. "The insulator protein CTCF and cohesins are critical for Herpesvirus saimiri genome maintenance = Das Insulatorprotein CTCF und Kohäsine sind kritisch für die Erhaltung der Genome von Herpesvirus saimiri / Katrin Zielke. Betreuer: Andreas Burkovski." Erlangen : Universitätsbibliothek der Universität Erlangen-Nürnberg, 2012. http://d-nb.info/1021259632/34.

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31

Gray, Christine Elizabeth. "Promoters, enhancers and insulators for improved mosquito transgenesis." Texas A&M University, 2005. http://hdl.handle.net/1969.1/4205.

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Low level and variable transgene expression plague efforts to produce and characterize transgenic lines in many species. When transformation efficiency is high, productive transgenic lines can be generated with reasonable effort. However, most efforts to date in mosquitoes have resulted in suboptimal levels of transformation. This, coupled with the large space and intensive labor requirements of mosquito colony maintenance makes the optimization of transformation in mosquitoes a research priority. This study proposes two strategies for improving transgene expression and transformation efficien

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32

Weatherford, Eric Thomas. "Regulation of renin gene expression by CTCF, Nr2f2, Nr2f6, Nr4a1 and maintenance of the renin expressing cell." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/1104.

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The renin angiotensin system (RAS) is critical for the regulation of blood pressure, electrolyte/fluid, and metabolic homeostasis. Regulation of the RAS is important in the development and treatment of hypertension. As part of the rate-limiting step in a cascade of events ending in the production of angiotensin II, renin is a major regulator of the RAS. Its expression is localized to the juxtaglomerular (JG) cells of the JG apparatus where it is exquisitely located to respond to various physiological cues. Understanding the regulation of renin expression and development of the juxtaglomerular

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33

Mendez-Catala, Claudia Fabiola. "Investigation into the molecular mechanisms of the anti-apoptotic function of CTCF in breast cancer cells." Thesis, University of Essex, 2011. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.548602.

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34

Braun, Frank Karl Horst. "Klärung der Ursachen der Apoptoseresistenz von kutanen T-Zel-Lymphomen und Entwicklung therapeutischer konzepte." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2011. http://dx.doi.org/10.18452/16379.

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Kutane T-Zell-Lymphome (CTCL) stellen eine heterogene Gruppe von non-Hodgkin-Lymphomen dar. Die häufigsten Entitäten sind die Mycosis fungoides, das Sézary-Syndrom sowie CD30+ lymphoproliferativen Erkrankungen (cALCL). Todesliganden-vermittelte Apoptose ist auch für die Lymphozyten-Homöostase von essentieller Bedeutung. Zunächst wurden die CTCL-Zelllinien mit systemischen T-Zell-Lymphomzellen hinsichtlich ihrer Apoptosesensitivität verglichen. Hierbei zeigte sich eine ausgesprochene Resistenz aller kutanen Zelllinien gegenüber TRAIL- und TNF-α-induzierter Apoptose. Anhand der Aktivierung der

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35

Mamayusupova, Hulkar. "Investigation into the molecular mechanisms and biological role of the interaction between CTCF and RNA Polymerase II." Thesis, University of Essex, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.654527.

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CTCF is a highly conserved, ubiquitously expressed zinc-finger protein with diverse regulatory functions, binding to tens of thousands of the CTCF target sites (CTS) in the genome. CTCF interacts with a number of proteins including the largest subunit of RNA Polymerase H (LS Pol II), previously studied in our laboratory. Two sites within the CTCF Cterminal domain (Site 1 and Site 2) were shown to be involved in the CTCF-LS Pol II binding. The main aim of this study is to further characterize CTCF-LS Pol II interaction and its role in the regulation of CTCF function in transcription. To achieve

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36

Woollard, Wesley Jackson. "Driver genes in CTCL : a genomic approach for screening and a detailed analysis of a candidate gene." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/driver-genes-in-ctcl(9dfa7df5-72cc-44f0-9e50-25a6a2ea8251).html.

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The cutaneous T-cell lymphomas (CTCLs) mycosis fungoides (MF) and Sézary syndrome (SS) are T-cell malignancies affecting the skin. The heterogeneous genomic landscape of CTCL has hindered the identification of driver genes. However, maturing sequencing technologies and candidate gene studies of chromosomal hotspots such as 9p21 can be used to identify putative driver events. The aims of this thesis were to investigate: (i) if MTAP (found on 9p21) undergoes selective loss; (ii) if MTAP loss affects dimethyl-arginine status; and (iii) identify putative driver genes of CTCL. Tumour samples from 2

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37

Dib, Carla. "développement d'approches de correction des myoblastes issus de patients atteints de la dystrophie facio-scapulo-humérale." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS224.

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La dystrophie Facio-Scapulo-Humérale est caractérisée par une faiblesse musculaire progressive et asymétrique. Elle affecte principalement les muscles faciaux, scapulaires et huméraux. L’association de plusieurs évènements épigénétiques à trois facteurs génétiques de la région subtélomérique du chromosome 4 résulte en un changement dans l’organisation chromatinienne la rendant permissive à l’expression aberrante des gènes de la région 4q35. Les myoblastes DFSH présentent des défauts de différenciation in vitro et des dérégulations dans des voies majeures comme celle de la réponse cellulaire au

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38

Boulanger, Mathias. "SUMOylation et contrôle de l’expression des gènes : implication dans la réponse à la chimiothérapie d’induction des Leucémies Aigües Myéloïdes." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTT067.

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Les Leucémies Aigues Myéloïdes (LAM) sont des hémopathies malignes au pronostic sombre. Leur traitement repose sur une chimiothérapie composée d’une anthracycline (daunorubicine [DNR] ou idarubicine) et d’un analogue de nucléotide (AraC). Cependant, les taux de rechutes sont très élevés. Il est donc critique de mieux comprendre les mécanismes d’actions de ces drogues chimiothérapeutiques pour mieux surmonter la chimiorésistance. Un aspect, essentiel à leur action thérapeutique mais encore mal connu, concerne leur capacité à réguler l’expression de gènes spécifiques qui participent à leur effet

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39

Ottaviani, Alexandre. "Modulation of the functional and perinuclear organization of the facio-scapulo-humeral muscular dystrophy (FSHD) locus by the D4Z4 macrosatellite element." Lyon, École normale supérieure (sciences), 2008. http://www.theses.fr/2008ENSL0492.

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La dystrophie musculaire Facio-Scapulo-Humérale (FSHD) est liée à la réduction du nombre de répétitions d’une séquence de 3,3 kb nommée D4Z4 dans la région subtélomérique 4q35. Les individus sains portent de 11 à plus de 100 répétitions D4Z4 tandis que ce nombre est inférieur à 11 sur l’un des allèles chez les malades. Dans ce mémoire, après une mise en perspective de l’organisation tridimensionnelle de la chromatine et de la transcription dans le noyau, et en particulier sous l’influence de l’enveloppe nucléaire, sont présentés l'état actuel des connaissances concernant l'étiologie de la FSHD

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40

Muck, Joscha Sergej. "CTCF, Lamin A/C und eine Histondeacetylase sind essentiell für die Positionierung des humanen CFTR-Gens an der Zellkernperipherie." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-149526.

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41

Gretton, Svetlana. "Investigation of the functional role of the transcription factor, CTCF, in the regulation of human Bax and p14ARF genes." Thesis, University of Essex, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589445.

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CTCF (CCCTC-binding factor) is a ubiquitously expressed, multifunctional and conserved ll-Zinc finger transcription factor. CTCF is involved in the regulation of various genes, including those responsible for proliferation and apoptosis, using different mechanisms. One such mechanisms is based on reversible poly(ADP-ribosyl)ation (PARylation) of CTCF at the CTCF target sites (CTSs) and requires cooperation between CTCF and the PARylation enzyme, PARP-l. The main aim of this study was to investigate the role ofCTCF, PARP-l and PARylation in the epigenetic regulation of a pro-apoptotic gene, Bax

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42

Liska, Olga. "Effect of CTCF and Cohesin on the dynamics of RNA polymerase II transcription and coupled pre-messenger RNA processing." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:ba9454b8-4498-42c8-bc4c-16dd971af164.

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The CCCTC-binding factor (CTCF) is a versatile, multifunctional zinc-finger protein involved in a broad spectrum of cellular functions. In mammalian cells, CTCF functions together with the Cohesin complex, an essential regulator of sister chromatid cohesion. Together, CTCF and Cohesin have been shown to regulate gene expression at a genome-wide level in mammalian cells. In the yeast Saccharomyces pombe, Cohesin has been implicated in transcription termination of convergently transcribed genes, in a cell cycle dependent manner. The aim of this thesis was to investigate the possibility of direct

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43

Shmela, Mansur Ennuri, and S3149770@student rmit edu au. "Mechanisms of DNA methylation defects at the IGF2/H19 imprinting centre in patients with foetal growth disorders." RMIT University. Medical Sciences, 2009. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20091023.120253.

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The imprinted expression of the IGF2 and H19 genes is controlled by the imprinting control region 1 (ICR1) located at chromosome 11p15.5. This methylation-sensitive chromatin insulator works by binding the zinc-finger protein CTCF in a parent-specific manner. CTCF binds the unmethylated maternal allele and is required for preventing de novo methylation at ICR1. DNA methylation defects involving the ICR1 IGF2/H19 domain result in two growth disorders with opposite phenotypes: an overgrowth disorder, the Beckwith-Wiedemann syndrome (ICR1 gain of methylation in 10% of BWS cases) and a growth re

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44

Lupey-Green, Lena Nicole. "PARP1-MEDIATED EPIGENETIC CONTROL OF LATENCY AND LYTIC REACTIVATION OF THE EPSTEIN BARR VIRUS." Diss., Temple University Libraries, 2017. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/463893.

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Biomedical Sciences<br>Ph.D.<br>Epstein Barr virus (EBV) is a gammaherpesvirus that infects more than 95% of the human population worldwide. EBV latent infection of B cells is associated with a variety of lymphomas and epithelial cancers and accounts for approximately 1% of all human cancers. The EBV genome persists in infected host cells as a chromatinized episome and is subject to chromatin-mediated regulation. Binding of the host insulator protein CTCF to the EBV genome has an established role in maintaining viral latency type, and in other herpesviruses, loss of CTCF binding at specific re

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45

Terrone, Sophie. "Connexion entre organisation 3D du génome et épissage alternatif médiée par les hélicases DDX5 et DDX17." Thesis, Lyon, 2019. https://n2t.net/ark:/47881/m6n015wq.

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L'épissage alternatif est le mécanisme permettant la production de plusieurs isoformes d'ARNs messagers à partir du même gène. La majorité des gènes humains sont concernés par ce processus. Epissage et transcription étant simultanés, les deux processus sont co-régulés. Plusieurs études récentes ont proposé que l'organisation tridimensionnelle du génome, qui régule la transcription, pourrait également moduler l'épissage. DDX5 et DDX17 sont deux hélicases à ARN impliquées dans plusieurs étapes de la biogenèse et de la maturation des ARNs, y compris la transcription et l'épissage. Des travaux de

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46

Robinson, Abigail Frances. "Molecular and biological approaches to investigate the biological role(s) of the 11 zinc finger transcription factor, CTCF, in the cell." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404369.

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47

Tavoosidana, Gholamreza. "Epigenetic Regulation of Genomic Imprinting and Higher Order Chromatin Conformation." Doctoral thesis, Uppsala universitet, Zoologisk utvecklingsbiologi, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7435.

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The genetic information encoded by the DNA sequence, can be expressed in different ways. Genomic imprinting is an epigenetic phenomenon that results in monoallelic expression of imprinted genes in a parent of origin-dependent manner. Imprinted genes are frequently found in clusters and can share common regulatory elements. Most of the imprinted genes are regulated by Imprinting Control Regions (ICRs). H19/Igf2 region is a well known imprinted cluster, which is regulated by insulator function of ICR located upstream of the H19 gene. It has been proposed that the epigenetic control of the insula

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48

Pérez, Rico Yuvia Alhelí. "Zebraﬁsh as a model to determine conserved gene regulatory mechanisms in vertebrates". Electronic Thesis or Diss., Sorbonne université, 2018. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2018SORUS535.pdf.

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Abstract:

Les super-ampliﬁcateurs et CTCF sont considérés comme des acteurs centraux de l'organisation du génome ayant un impact direct sur la régulation de l'expression génique. Ici, pour mieux comprendre leur conservation fonctionnelle, des analyses de super-ampliﬁcateurs et de CTCF chez le poisson zèbre ont été effectuées. Les super-ampliﬁcateurs annotés dans le génome du poisson zèbre présentent une grande spéciﬁcité cellulaire et tissulaire. Des analyses de conservation indiquent que les super-ampliﬁcateurs n'ont pas une conservation de séquence supérieure à celle des ampliﬁcateurs. En limitant l'a

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Chowdhary, Vivek K. "Role of miR-122 in Acetaminophen Induced Liver Injury." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1494133473685399.

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50

Rodari, Anthony. "New insights into Bovine Leukemia Virus (BLV) transcriptional and epigenetic regulations :characterization of alternative promoters and implications of CTCF in this transcriptional network." Doctoral thesis, Universite Libre de Bruxelles, 2018. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/270300.

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Abstract:

Bovine Leukemia Virus (BLV) latency is a viral strategy used to escape from the host immune system and contribute to tumor development. However, the recent discovery of a highly expressed miRNA cluster has suggested that BLV latency is partially true. In our PhD thesis, we studied the epigenetic and transcriptional regulations of this RNA polymerase III (RNAPIII)- dependent miRNA cluster and of a newly discovered RNA polymerase II (RNAPII)-dependent promoter (which drives an active antisense transcription). Moreover, our data suggested a putative collision phenomenon between RNAPII and RNAPIII

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